Professor Michael Barrett

  • Professor of Biochemical Parasitology (Parasitology)
  • Associate - Life Sciences (School of Life Sciences)
  • Affiliate (Polyomics Facility)

telephone: 01413306904
email: Michael.Barrett@glasgow.ac.uk

Research interests

Current research :

A focus on understanding how drugs work against parasites and how parasites become resistant to drugs. In the case of African trypanosomiasis, transport related phenomena have been central and a major research area has been associated with understanding drug resistance.  This has led to the discovery of new transporters involved in uptake of melaminophenylarsenical and diamidine drugs and eflornithine.  In Leishmania changes in drug uptake have also been identified for paromomycin, pentamidine and amphotericin B in selection of drug resistance.  Prof Barrett chairs the Kinetoplastids Drug efficacy working group at the World Health Organisation.  Since many drugs work at the level of interference with metabolism he has also pioneered work into biochemistry of parasites, identifying several drug targets and also founded the Scottish Metabolomics facility which is now able to report on metabolomics data outputs in any system, and is now part of the Glasgow Polyomics Facility which is involved in collecting metabolomics, genomics and proteomics data and analysing the data within an active bioinformatics hub. Prof Barrett is also interested in developing new screens for drugs, including an in vivo imaging model to determine whether drugs act in stage 2 human African trypanosomiasis, and is Director of New Projects at the Consortium of Parasitic Drug Development.  He also is involved in scientific outreach, appearing on radio, television and writing frequently in magazines and newspapers on topics in tropical medicine and application of Omics research.

Scientific Advisory board of "Developing World Health"

The Scottish Encounter with Tropical Disease 2012

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Parasite induced changes to the metabolome of insect vectors of disease
    Royal Society
    2016 - 2018
     
  • A new drug discovery pipeline for animal African trypanosomiasis
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • A new drug discovery pipeline for animal African trypanosomiasis
    GALVmed
    2016 - 2019
     
  • Drug resistance and cross-resistance in livestock trypanosomes.
    Bill and Melinda Gates Foundation
    2016 - 2016
     
  • Thiol Modification and Redox Signalling
    Medical Research Council
    2016 - 2017
     
  • Discovery of New Drug Candidate(s) for the Treatment of Human African Trypanosomiasis (HAT)
    Wellcome Trust
    2016 - 2018
     
  • Cost-effective community access to integrated information for microbial eukaryotic pathogen research
    Wellcome Trust
    2016 - 2020
     
  • Enhanced interpretation of metabolomics data to accelerate microbial engineering
    Innovate UK
    2015 - 2017
     
  • Stability of polyomic signatures in RA to facilitate transition to clinical practice - STABILITY-RA
    Scottish Executive Health Department
    2015 - 2017
     
  • Glasgow Molecular Pathology (GMP) Node
    Medical Research Council
    2015 - 2018
     
  • Ancestry and biological informative markers for stratification of hypertension - The AIM HY study
    Medical Research Council
    2015 - 2020
     
  • Regulation of stem cell function during tissue homeostasis and transformation
    Wellcome Trust
    2015 - 2020
     
  • In vivo screening resource to support drug development in parasitic disease
    Wellcome Trust
    2015 - 2017
     
  • Identification and analysis of essential proteins involved in Toxoplasma gondii mitochondrial tRNA import (ISSF Fellowship)
    Wellcome Trust
    2015 - 2015
     
  • Mathematical modelling of the interaction between leishmania and the macrophage using omics data (ISSF Fellowships)
    Wellcome Trust
    2015 - 2015
     
  • Validation of metabolomics as a technique to identify determinants of treatment response in HCV infection (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Tracing transmission pathways of endemic canine rabies (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Comparing the fitness and patient landscapes of HIV-1 (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Microparticles as carriers of genetic material - a new mechanism of intercellular communication that underlies the pathogenesis of rheumatoid arthritis
    Tenovus-Scotland
    2014 - 2015
     
  • Identification of stage-specific promoter elements in photosynthetic bacteria (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Investigating The Molecular Basis for Stromal Memory Following Influenza Virus Infection (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • The Wellcome Centre for Molecular Parasitology ( Core Support )
    Wellcome Trust
    2014 - 2021
     
  • Institutional Strategic Support Fund (ISSF)
    Wellcome Trust
    2014 - 2017
     
  • Essential or redundant: Dissection of apicomplexan invasion mechanisms
    Wellcome Trust
    2014 - 2019
     
  • Genetic Determinants of Trypanotolerance in Humans (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Biomarker Discovery 2.0 - Rigorous and Robust Metabolite Characterization using Mass Spectrometry Fragmentation approaches (ISSF Fellowship)
    Wellcome Trust
    2014 - 2015
     
  • Modes of Action and Mechanisms of Resistance to the Novel Benzoxaborole Class of Drug against Human African Trypanosomiasis
    Medical Research Council
    2014 - 2017
     
  • Enabling Stratified Medicine in Early Rheumatoid Arthritis - predicting methotrexate (MTX) response and toxicity using an integrated polyomic approach (PROMISERA)
    Scottish Funding Council
    2014 - 2016
     
  • Drug resistance and cross-resistance in livestock trypanosomes.
    GALVmed
    2014 - 2016
     
  • USE OF METABOLOMICS TO DETERMINE MODES OF ACTION OF NOVEL ANTI-LEISHMANIAL COMPOUNDS
    Tres Cantos Open Lab Foundation
    2014 - 2016
     
  • Systematic analysis of genes and gene networks that modulate differential macrophage response to Toxoplasma gondii and inflammatory stimuli
    Wellcome Trust
    2014 - 2015
     
  • Molecular epidemiology of Clostridium difficile in Scotland - developing novel, clinically applicable research methods to combine genomic analysis with health informatics
    Scottish Executive Health Department
    2014 - 2015
     
  • A new urinary biomarker for stroke
    Medical Research Council
    2014 - 2015
     
  • Diamidine and oxaborole transporters and resistance in livestock tryponosomes (Gap Period)
    Gates Foundation
    2014 - 2014
     
  • Omics of adaption to changing/novel environments in plants (ISSF STS)
    Wellcome Trust
    2014 - 2014
     
  • In vivo imaging models of African trypanosomiasis to support drug discovery programmes
    Gates Foundation
    2014 - 2014
     
  • The use of polyomic analyses to direct biologic therapy in biologic-naive people with Rheumatoid Arthritis
    Scottish Executive Health Department
    2013 - 2015
     
  • Integron and omics based acceleration of industrial strain development
    Biotechnology and Biological Sciences Research Council
    2013 - 2015
     
  • Institutional Strategic Support Fund (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • Funding Schemes
    Wellcome Trust
    2013 - 2014
     
  • Funding Schemes (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • LAPASO
    European Commission
    2013 - 2017
     
  • Development of bioinformatic analysis pipelines to integrate transcriptomic and metabolomic data to map the alpha 7 nicotinic receptor... (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • A polyomics based approach to identify molecular pathways and genetic modifiers which influence the development of stroke caused by collagen IV mutations (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • The Urine Microbiome of Livestock and Wildlife as Source of Zoonotic Bacteria in Tanzania (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • Modulation of the kynurenic pathway following stroke (ISSF STS)
    Wellcome Trust
    2013 - 2014
     
  • Prenatal programming of adult disease by maternal smoking: the adrenal gland as a key player? (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • Diamidine transporters and resistance in livestock trypanosomes.
    GALVmed
    2013 - 2014
     
  • Phylodynamics of Mycobacterium bovis in badgers (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • Gene expression and metabolomic phenotype in response to artificial light at night (ISSF STS)
    Wellcome Trust
    2013 - 2014
     
  • Characterisation of Mesenchymal Stem Cells in a 3D Niche Mimic via Microarray (ISSF)
    Wellcome Trust
    2013 - 2013
     
  • Wild Immunomics: characterising protective immunity to helminth infection by integrating transcriptomes and metabolomes of wild rodents (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • Genetic diversity and population dynamics of Cryptosporidium species and the use of next generation sequencing data to improve diagnostic and outbreak source identification tools. (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • Exome Sequencing for the Genetic Diagnosis of Rare Diseases: Fostering a New Working Relationship between the NHS, the University of Glasgow and Glasgow Polyomics (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • Novel approaches to recreating animal histories: the metabolic signature of hair (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • Exome Sequencing for the Genetic Diagnosis of Rare Diseases: Fostering a New Working Relationship between the NHS, the University of Glasgow and Glasgow Polyomics (ISSF)
    Wellcome Trust
    2013 - 2015
     
  • Detecting population trends for tick-borne pathogens from genomic data: new tools for managing Lyme disease in Scotland (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • Next generation RNA sequencing predicts patient responses to B cell depletion therapy in rheumatoid arthritis (ISSF Catalyst)
    Wellcome Trust
    2013 - 2013
     
  • Make Mine Metagenomics: An international collaboration to explore the milk microbiome in dairy cattle (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • The Multi-Corder: Poly-Sensor Technology
    Engineering & Physical Sciences Research Council
    2013 - 2017
     
  • Antiparasitic pyrrolopyrimidines
    Medical Research Council
    2013 - 2013
     
  • Integron and omics based acceleration of industrial strain development
    Biotechnology and Biological Sciences Research Council
    2012 - 2014
     
  • Institutional Strategic Support Fund (ISSF)
    Wellcome Trust
    2012 - 2014
     
  • Integrated bioinformatics resources for kinetoplastid pathogens.
    Wellcome Trust
    2012 - 2015
     
  • Bayesian Methods for Metabolite Identification and Analysis (ISSF 2012)
    Wellcome Trust
    2012 - 2013
     
  • ParaMet - A systematic approach to understanding parasite metabolism.
    European Commission
    2012 - 2016
     
  • Diamidine transporters and resistance in livestock trypanosomes
    Department for International Development
    2012 - 2013
     
  • Integrated Health - Polyomics and Systems Biomedicine (ISSF Bid)
    Wellcome Trust
    2011 - 2014
     
  • Using Polyomics for Target Identification on P. falciparum and T. brucei (ISSF 2012)
    Wellcome Trust
    2011 - 2014
     
  • Adapting cell phone technology for the diagnosis of malaria
    Gates Foundation
    2011 - 2012
     
  • The silicon trypanosome (SilicoTryp)
    BBSRC
    2010 - 2013
     
  • Antiparasitic pyrrolopyrimidines
    MRC
    2010 - 2013
     
  • SULSA Chair in Systems Biology - Cathcart Chair
    Scottish Funding Council
    2010 - 2014
     
  • In vivo imaging models of African trypanosomiasis to support drug discovery programmes.
    Gates Foundation
    2010 - 2012
     
  • KTA-EPSRC: Metabolic Diagnostics on a Chip
    Engineering & Physical Sciences Research Council
    2009 - 2012
     
  • KTA-EPSRC: Metabolomic Diagnostics on a Chip
    Engineering & Physical Sciences Research Council
    2009 - 2012
     
  • Drug resistance in African trypanosomes
    MRC
    2008 - 2011
     
  • Metabolomic systems biology analysis of differentiation in trypanosomes
    BBSRC
    2008 - 2011
     
  • Scottish Universities Life Sciences Alliance (SULSA)- Systems Biology
    Scottish Funding Council
    2008 - 2015
     
  • Assessment of the probability of developing resistance to novel trypanocides under consideration for late stage HAT
    The University of North Carolina at Chapel Hill
    2006 - 2010
     
  • Design & Synthesis of Potential Agents for the Treatment of African Trypanosomiasis
    Drugs for Neglected Diseases Initiative
    2006 - 2006
     
  • Use of transporters to selectively deliver agents to trypanosomes
    MRC
    2006 - 2009
     
  • Energy metabolism in trypanosomatic parasites - a target for new drugs
    British Council
    2006 - 2007
     
  • Surveillance of drug resistance in trypanosomiasis
    World Health Organisation/TDR
    2005 - 2006
     
  • The molecular basis of functional divergence between structurally similar monosaccharide transporters in Leishmania
    Wellcome Trust
    2005 - 2009
     
  • Inhibitors of trypanosomal 6-phosphogluconate dehydrogenase - modes of action and drug delivery strategies
    Wellcome Trust
    2005 - 2008
     
  • Combatting drug resistance in human African trypanosomiasis
    UBS-Optimus
    2004 - 2007
     
  • Molecular genetics and biochemistry of parasites
    MRC
    2004 - 2009
     
  • A diagnostic test for drug resistance in African trypanosomes
    Wellcome Trust
    2003 - 2005
     
  • Development Novel Drug Candidates Treatment of Human African Trypanosomiasis & Leish
    The University of North Carolina at Chapel Hill
    2002 - 2006
     
  • Molecular and Biochemical mechanisms of pentamidine resistance in Leishmanaia
    Wellcome Trust
    2002 - 2005
     

Additional information

Editorial Board

  • 2013 - ongoing: Molecular and Biochemical Parasitology
  • 2012 - ongoing: International Journal of Parasitology - Drugs and drug resistance
  • 1998 - 2004: Letters in Applied Microbiology
  • 1996 - 2004: Journal of Applied Microbiology
  • 1996 - ongoing: Biochemical Journal

Grant Advisory Board

  • 2004 - ongoing: WHO - Chairman of the Drug Resistance working group of the Tripanosomiasis Network
  • 2004 - 2008: WHO - Chairman of the Treatment Failure Working Group of Human African Trypanosomiasis Network (HATNET)
  • 2004 - ongoing: WHO - Expert Committee on human African trypanosomiasis
  • 2004 - ongoing: WHO - Committee, Treatment and Drug Resistance Network for Sleeping Sickness
  • 2001 - ongoing: WHO Scientific Working Group - African Trypanosomiasis
  • 2000 - 2002: European Commission Framework V - Evaluator, Quality of Life

Invited International Presentations

  • 2013: Geneva, Switzerland - World Health Organisation: Drug efficacy in neglected tropical diseases, "Drug efficacy in the Kinetoplastida"
  • 2012: Ottawa, Ontario, Canada - Gates Grand Challenges meeting, "In vivo imaging systems for stage 2 human African trypanosomiasis (HAT)"
  • 2012: Atlanta, Georgia, USA - American Society of Tropical Medicine and Hygiene, "Drug resistance in human African trypanosomiasis"
  • 2012: Paris, France - French trypanosomatids group, "Metabolic analysis of trypanosomes"
  • 2012: Brussels, Belgium - Michels/Opperdoes symposium, "The decline in human African trypanosomiasis - metabolism under siege", De Duve Centre
  • 2012: Nantes, France - French Network in Metabolomics and Fluxomics, "Identifying drug modes of action using metabolomics"
  • 2012: Geneva, Switzerland - World Health Organisation: Drug efficacy in neglected tropical diseases, "Drug efficacy in the Kinetoplastida"
  • 2012: Lysen, Switzerland - Swiss Trypanosomiasis group meeting, "Drug induced changes to the T. brucei metabolome"
  • 2011: Philadelphia, Pennsylvania, USA - American Society of Tropical Medicine and Hygiene, "Drug induced changes to the T. brucei metabolome"
  • 2011: Clearwater, Florida, USA - Consortium of Parasitic Drug Development, "Drug discovery for trypanosomiasis"
  • 2011: Geneva, Switzerland - World Health Organisation: Drug efficacy in neglected tropical diseases, "Treatment failures in human African trypanosomiasis"
  • 2010: Paris, France - EC Conference on neglected protozoan diseases, "Innovative drug discovery for human African trypanosomiasis"
  • 2002: Chapel Hill, North Carolina, USA - Gates Consortium: New drugs for trypanosomiasis and Leishmaniasis, University of North Carolina

Professional Learned Society

  • 2013 - ongoing: Royal Society of Edinburgh - Elected Fellow
  • 2011 - ongoing: Developing World Health - Scientific Advisor

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999
Number of items: 139.

2015

Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P., McConville, M. J., and Waters, A. P. (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi:10.1371/journal.ppat.1004882) (PMID:26042734)

Coles, J. A., Myburgh, E., Ritchie, R., Hamilton, A., Rodgers, J., Mottram, J. C., Barrett, M. P., and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi:10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi:10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

Alkhaldi, A.A.M., Creek, D.J., Ibrahim, H., Kim, D.-H., Quashie, N.B., Burgess, K.E., Changtam, C., Barrett, M.P., Suksamrarn, A., and De Koning, H.P. (2015) Potent Trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with Trypanothione. Molecular Pharmacology, 87(3), pp. 451-464. (doi:10.1124/mol.114.096016)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi:10.1093/nar/gku944)

Hai, Y., Kerkhoven, E. J., Barrett, M., and Christianson, D. W. (2015) Crystal structure of an arginase-like protein fromtrypanosoma bruceithat evolved without a binuclear manganese cluster. Biochemistry, 54(2), pp. 458-471. (doi:10.1021/bi501366a) (PMID:25536859)

van der Hooft, J., Ridder, L., Barrett, M. P., and Burgess, K. V. (2015) Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines. Frontiers in Bioengineering and Biotechnology, 3, p. 26. (doi:10.3389/fbioe.2015.00026) (PMID:25806366) (PMCID:PMC4353373)

2014

Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P., Pellacani, C., Poli, P., and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi:10.1128/AAC.01449-13)

Achcar, F., Kerkhoven, E. J., and Barrett, M. P. (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi:10.1016/j.mib.2014.06.007)

Bourquin, Y., Syed, A., Reboud, J., Ranford-Cartwright, L. C., Barrett, M. P., and Cooper, J. M. (2014) Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angewandte Chemie, 53(22), pp. 5587-5590. (doi:10.1002/ange.201310401)

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi:10.1093/jac/dkt442)

Giordani, F., Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W., and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi:10.1128/AAC.02024-13)

Chokkathukalam, A., Kim, D.-H., Barrett, M. P., Breitling, R., and Creek, D. J. (2014) Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis, 6(4), pp. 511-524. (doi:10.4155/bio.13.348)

Kremer, C., Witte, C., Neale, S. L., Reboud, J., Barrett, M. P., and Cooper, J. M. (2014) Shape-dependent optoelectronic cell lysis. Angewandte Chemie (International Edition), 53(3), pp. 842-846. (doi:10.1002/anie.201307751) (PMID:24402800) (PMCID:PMC4441254)

Barrett, M. P., and Croft, S. L. (2014) Emerging paradigms in anti-infective drug design. Parasitology, 141(1), pp. 1-7. (doi:10.1017/S0031182013001224)

Creek, D. J., and Barrett, M. P. (2014) Determination of antiprotozoal drug mechanisms by metabolomics approaches. Parasitology, 141(1), pp. 83-92. (doi:10.1017/S0031182013000814)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi:10.1016/B978-0-12-800143-1.00003-8)

Giordani, F., Mwenechanya, R., and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan , S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi:10.1016/B978-0-12-386882-4.00039-6)

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L., and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi:10.1021/jm500483b)

Oppenheim, R. D. et al. (2014) BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens, 10(7), e1004263. (doi:10.1371/journal.ppat.1004263) (PMID:25032958) (PMCID:PMC4102578)

Trochine, A., Creek, D. J., Faral-Tello, P., Barrett, M. P., and Robello, C. (2014) Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics. PLoS Neglected Tropical Diseases, 8(5), e2844. (doi:10.1371/journal.pntd.0002844)

2013

Munday, J.C., Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P., Morrison, L.J., and De Koning, H.P. (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi:10.1016/j.ijpddr.2013.01.004)

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi:10.1111/mmi.12351)

Achcar, F., Barrett, M.P., and Breitling, R. (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi:10.1111/febs.12436)

Barrett, M.P., Gemmell, C.G., and Suckling, C.J. (2013) Minor groove binders as anti-infective agents. Pharmacology and Therapeutics, 139(1), pp. 12-23. (doi:10.1016/j.pharmthera.2013.03.002)

Creek, D. J., Nijagal, B., Kim, D.-H., Rojas, F., Matthews, K. R., and Barrett, M. P. (2013) Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy, 57(6), pp. 2768-2779. (doi:10.1128/AAC.00044-13)

Kim, D.-H., and Barrett, M.P. (2013) Metabolite-dependent regulation of gene expression in trypanosoma brucei. Molecular Microbiology, 88(5), pp. 841-845. (doi:10.1111/mmi.12243)

Limenitakis, J., Oppenheim, R.D., Creek, D.J., Foth, B.J., Barrett, M.P., and Soldati-Favre, D. (2013) The 2-methylcitrate cycle is implicated in the detoxification of propionate inToxoplasma gondii. Molecular Microbiology, 87(4), pp. 894-908. (doi:10.1111/mmi.12139)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P., and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi:10.1093/bioinformatics/bts674)

Creek, D.J., Vincent, I.M., and Barrett, M.P. (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi:10.1002/9783527670383.ch3)

De Muylder, G. et al. (2013) A trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathogens, 9(10), e1003731. (doi:10.1371/journal.ppat.1003731)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS ONE, 9(12), e1003371. (doi:10.1371/journal.pcbi.1003371)

Myburgh, E., Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J., Taylor, M., Barrett, M., Brewer, J., and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi:10.1371/journal.pntd.0002384)

2012

Creek, D.J., Chokkathukalam, A., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P. (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry, 84(20), pp. 8442-8447. (doi:10.1021/ac3018795)

Clark, R.L., Clements, C.J., Barrett, M.P., Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J., and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20(20), pp. 6019-6033. (doi:10.1016/j.bmc.2012.08.049)

Baker, N., Glover, L., Munday, J. C., Aguinaga Andres, D., Barrett, M. P., De Koning, H. P., and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi:10.1073/pnas.1202885109)

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P., and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi:10.1371/journal.pcbi.1002352)

Barrett, M.P., and Croft, S.L. (2012) Management of trypanosomiasis and leishmaniasis. British Medical Bulletin, 104(1), pp. 175-196. (doi:10.1093/bmb/lds031)

Bringaud, F., Barrett, M., and Zilberstein, D. (2012) Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience, 17(1), p. 349. (doi:10.2741/3931)

Creek, D., Anderson, J., McConville, M.J., and Barrett, M.P. (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181(2), pp. 73-84. (doi:10.1016/j.molbiopara.2011.10.003)

Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P. (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28(7), pp. 1048-1049. (doi:10.1093/bioinformatics/bts069)

Menachery, A., Kremer, C., Wong, P.E., Carlsson, A., Neale, S.L., Barrett, M.P., and Cooper, J.M. (2012) Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Scientific Reports, 2(775), (doi:10.1038/srep00775)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S., and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi:10.1371/journal.pntd.0001618)

Zhang, T., Creek, D.J., Barrett, M.P., Blackburn, G., and Watson, D.G. (2012) Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry, 84(4), pp. 1994-2001. (doi:10.1021/ac2030738)

2011

Burgess, K., Creek, D., Dewsbury, P., Cook, K., and Barrett, M.P. (2011) Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3447-3452. (doi:10.1002/rcm.5247)

Leader, D.P., Burgess, K., Creek, D., and Barrett, M.P. (2011) Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3422-3426. (doi:10.1002/rcm.5245)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N., and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi:10.2217/fmb.11.88)

Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi:10.1124/mol.111.071555)

Holm, S. H., Beech, J. P., Barrett, M. P., and Tegenfeldt, J. O. (2011) Separation of parasites from human blood using deterministic lateral displacement. Lab on a Chip, 11(7), pp. 1326-1332. (doi:10.1039/c0lc00560f)

Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P., and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi:10.1002/rcm.4939)

Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P., Wong, P.E., Male, L., Coles, S.J., and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19(5), pp. 1802-1815. (doi:10.1016/j.bmc.2011.01.010)

Brun, R., Don, R., Jacobs, R.T., Wang, M.Z., and Barrett, M.P. (2011) Development of novel drugs for human African trypanosomiasis. Future Microbiology, 6(6), pp. 677-691. (doi:10.2217/fmb.11.44)

Creek, D.J., Jankevics, A., Breitling, R., Watson, D.G., Barrett, M.P., and Burgess, K.E.V. (2011) Toward global metabolomics snalysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry, 83(22), pp. 8703-8710. (doi:10.1021/ac2021823)

Rodgers, J., Jones, A., Gibaud, S., Bradley, B., McCabe, C., Barrett, M. P., Gettinby, G., and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi:10.1371/journal.pntd.0001308)

Rogers, S., Scheltema, R.A., Barrett, M., and Breitling, R. (2011) Bayesian approaches for mass spectrometry-based metabolomics. In: Stumpf, M.P.H., Balding, D.J. and Girolami, M. (eds.) Handbook of Statistical Systems Biology. John Wiley & Sons: Chichester, UK, pp. 467-476. ISBN 9780470710869 (doi:10.1002/9781119970606.ch24)

Stoffel, S.A., Alibu, V.P., Hubert, J., Ebikeme, C., Portais, J.C., Bringaud, F., Schweingruber, M.E., and Barrett, M. (2011) Transketolase in Trypanosoma brucei. Molecular and Biochemical Parasitology, 179(1), pp. 1-7. (doi:10.1016/j.molbiopara.2011.04.006)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P., and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi:10.1128/AAC.01551-10)

2010

Barrett, M. P. (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Current Opinion in Infectious Diseases, 23(6), pp. 603-608. (doi:10.1097/QCO.0b013e32833f9fd0)

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P., and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi:10.1074/jbc.M110.106815)

Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R., and Barrett, M.P. (2010) The silicon trypanosome. Parasitology, 137(9), pp. 1333-1341. (doi:10.1017/S0031182010000466)

Barrett, M.P., Bakker, B.M., and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137(9), pp. 1285-1290. (doi:10.1017/S003118201000017X)

Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11(8), pp. 876-883.

Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M.P., Brenk, R., and Gilbert, I. H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorganic and Medicinal Chemistry, 18(14), pp. 5056-5062. (doi:10.1016/j.bmc.2010.05.077)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343.

Conti, P., Pinto, A., Wong, P.E., Major, L.L., Tamborini, L., Iannuzzi, M.C., De Micheli, C., Barrett, M.P., and Smith, T.K. (2010) Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor. Chemmedchem, 6(2), pp. 329-333. (doi:10.1002/cmdc.201000417)

Cottret, L., Wildridge, D., Vinson, F., Barrett, M.P., Charles, H., Sagot, M.-F., and Jourdan, F. (2010) MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Research, 38(Suppl ), W132-W137. (doi:10.1093/nar/gkq312)

González, D., Pérez, J.L., Serrano, M.L., Igoillo-Esteve, M., Cazzulo, J.J., Barrett, M.P., Bubis, J., and Mendoza-León, A. (2010) The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction. Journal of Molecular Microbiology and Biotechnology, 19(4), pp. 213-223. (doi:10.1159/000320697)

Jourdan, F., Cottret, L., Huc, L., Wildridge, D., Scheltema, R., Hillenweck, A., Barrett, M.P., Zalko, D., Watson, D. G., and Debrauwer, L. (2010) Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics, 6(2), pp. 312-321. (doi:10.1007/s11306-009-0196-9)

Klee, N., Wong, P. E., Baragana, B., Mazouni, F. E., Phillips, M. A., Barrett, M.P., and Gilbert, I. H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry Letters, 20(15), pp. 4364-4366. (doi:10.1016/j.bmcl.2010.06.070)

Ruda, G.F., Wong, P.E., Alibu, V.P., Norval, S., Read, K.D., Barrett, M.P., and Gilbert, I.H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds. Journal of Medicinal Chemistry, 53(16), pp. 6071-6078. (doi:10.1021/jm1004754)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S., and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi:10.1371/journal.ppat.1001204)

Ward, C. P., Burgess, K. E.V., Burchmore, R.J.S., Barrett, M.P., and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi:10.1016/j.molbiopara.2010.07.002)

2009

Kazibwe, A.J.N., Nerima, B., De Koning, H.P., Mäser, P., Barrett, M.P., and Matovu, E. (2009) Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases, 3(9), e523. (doi:10.1371/journal.pntd.0000523)

Mukhopadhyay, A., Chen, C.Y., Doerig, C., Henriquez, F.L., Roberts, C.W., and Barrett, M.P. (2009) The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX. Parasitology, 136(7), pp. 747-755. (doi:10.1017/S0031182009006027)

Rodgers, J., Stone, T.W., Barrett, M.P., Bradley, B.M., and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi:10.1093/brain/awp074)

Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P., and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164(2), pp. 111-117. (doi:10.1016/j.molbiopara.2008.12.007)

Wenzel, N., Wong, P.E., Maes, L., Muller, T.J., Krauth-Siegel, R.L., Barrett, M.P., and Davioud-Charvet, E. (2009) Unsaturated mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4(3), pp. 339-351. (doi:10.1002/cmdc.200800360)

Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M.P., and Gilbert, I.H. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic and Biomolecular Chemistry, 7(6), pp. 1154-1166. (doi:10.1039/b813394h)

Chollet, C., Baliani, A., Wong, P.E., Barrett, M.P., and Gilbert, I.H. (2009) Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry, 17(6), pp. 2512-2523. (doi:10.1016/j.bmc.2009.01.058)

Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P., Wilson, W.D., and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284(49), pp. 34028-34035. (doi:10.1074/jbc.M109.049726)

2008

Scheltema, R.A., Kamleh, A., Wildridge, D., Ebikeme, C., Watson, D.G., Barrett, M., Jansen, R.C., and Breitling, R. (2008) Increasing the mass accuracy of high-resolution LC-MS data using background ions - a case study on the LTQ-Orbitrap. Proteomics, 8(22), pp. 4647-4656. (doi:10.1002/pmic.200800314)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.., and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi:10.1002/rcm.3564)

Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P., Franconi, J.M., and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283(24), pp. 16342-16354. (doi:10.1074/jbc.M709592200)

Ebikeme, C.E., Peacock, L., Coustou, V., Riviere, L., Bringaud, F., Gibson, W.C., and Barrett, M.P. (2008) N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology, 135(5), pp. 585-594. (doi:10.1017/S0031182008004241)

Checchi, F., and Barrett, M.P. (2008) African sleeping sicknesss - Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored. British Medical Journal, 336(7646), pp. 679-680. (doi:10.1136/bmj.39505.490544.BE)

Breitling, R., Vitkup, D., and Barrett, M.P. (2008) New surveyor tools for charting microbial metabolic maps. Nature Reviews Microbiology, 6, pp. 156-161. (doi:10.1038/nrmicro1797)

Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J., and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18(7), pp. 2455-2458. (doi:10.1016/j.bmcl.2008.02.037)

Arrighi, R. B. G., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L.C., Barrett, M.P., Langel, U., and Faye, I. (2008) Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrobial Agents and Chemotherapy, 52(9), pp. 3414-3417. (doi:10.1128/AAC.01450-07)

Checchi, F., Filipe, J.A.N., Barrett, M.P., and Chandramohan, D. (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS Neglected Tropical Diseases, 2(12), e303. (doi:10.1371/journal.pntd.0000303)

Jourdan, F., Breitling, R., Barrett, M.P., and Gilbert, D. (2008) MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics, 24(1), pp. 143-145. (doi:10.1093/bioinformatics/btm536)

Reid, C. M., Ebikeme, C., Barrett, M.P., Patzewitz, E.-M., Muller, S., Robins, D. J., and Sutherland, A. (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi:10.1016/j.bmcl.2008.09.047)

2007

Sundaramoorthy, R., Iulek, J., Barrett, M. P., Bidet, O., Ruda, G. F., Gilbert, I. H., and Hunter, W. N. (2007) Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. FEBS Journal, 274(1), pp. 275-286. (doi:10.1111/j.1742-4658.2006.05585.x)

Barrett, M. (2007) Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology, 152(8), pp. 1155-1171. (doi:10.1038/sj.bjp.0707354)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S., and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Ogbunude, P., Lamour, N., and Barrett, M. (2007) Molecular cloning, expression and characterization of ribokinase of Leishmania major. Acta Biochimica et Biophysica Sinica, 39, pp. 462-466. (doi:10.1111/j.1745-7270.2007.00298.x)

2006

Anene, B.M., Ezeokonkwo, R.C., Mmesirionye, T.I., Tettey, J.N.A., Brock, J.M., Barrett, M.P., and De Koning, H.P. (2006) A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 132(1), pp. 127-133. (doi:10.1017/S0031182005008760)

Barrett, M., and Gilbert, I. (2006) Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology, 63, pp. 125-183. (doi:10.1016/S0065-308X(06)63002-9)

Breitling, R., Ritchie, S., Goodenowe, D., Stewart, M., and Barrett, M. (2006) Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data. Metabolomics, 2, pp. 155-164. (doi:10.1007/s11306-006-0029-z)

Dardonville, C., Barrett, M., Brun, R., Kaiser, M., Tanious, F., and Wilson, W. (2006) DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. Journal of Medicinal Chemistry, 49, pp. 3748-3752. (doi:10.1021/jm060295c)

Lanteri, C.A., Stewart, M.L., Brock, J.M., Alibu, V.P., Meshnick, S.R., Tidwell, R.R., and Barrett, M.P. (2006) Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology, 70(5), pp. 1585-1592. (doi:10.1124/mol.106.024653)

Mukherjee, A., Padmanabhan, P., Sahani, M., Barrett, M., and Madhubala, R. (2006) Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145, pp. 1-10. (doi:10.1016/j.molbiopara.2005.08.016)

2005

Baliani, A., Bueno, G., Stewart, M., Yardley, V., Brun, R., Barrett, M., and Gilbert, I. (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. Journal of Medicinal Chemistry, 48, pp. 5570-5579. (doi:10.1021/jm050177+)

Besteiro, S., Barrett, M., Riviere, L., and Bringaud, F. (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends in Parasitology, 21, pp. 185-191.

Croft, S., Barrett, M., and Urbina, J. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends in Parasitology, 21, pp. 508-512. (doi:10.1016/j.pt.2005.08.026)

Lamour, N., Riviere, L., Coustou, V., Coombs, G., Barrett, M., and Bringaud, F. (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280, pp. 11902-11910. (doi:10.1074/jbc.M414274200)

Stewart, M., Boussard, C., Brun, R., Gilbert, I., and Barrett, M. (2005) Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter. Antimicrobial Agents and Chemotherapy, 49, pp. 5169-5171. (doi:10.1128/AAC.49.12.5169-5171.2005)

Stewart, M., Krishna, S., Burchmore, R., Brun, R., de Koning, H., Boykin, D., Tidwell, R., Hall, J., and Barrett, M. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi:10.1016/S0140-6736(05)66793-1)

2004

Janssen, C.S., Phillips, R.S., Turner, C., and Barrett, M.P. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32(19), pp. 5712-5720. (doi:10.1093/nar/gkh907)

Azema, L. et al. (2004) Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochemical Pharmacology, 67, pp. 459-467. (doi:10.1016/j.bcp.2003.09.005)

Dardonville, C., Rinaldi, E., Barrett, M., Brun, R., Gilbert, I., and Hanau, S. (2004) Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. Journal of Medicinal Chemistry, 47, pp. 3427-3437. (doi:10.1021/jm031066i)

Hanau, S., Rinaldi, E., Dallocchio, F., Gilbert, I., Dardonville, C., Adams, M., Gover, S., and Barrett, M. (2004) 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes. Current Medicinal Chemistry, 11, pp. 2639-2650.

Janssen, C., Phillips, R., Turner, C., and Barrett, M. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32, pp. 5712-5720. (doi:10.1093/nar/gkh907)

Stewart, M.L., Bueno, G.J., Baliani, A., Klenke, B., Brun, R., Brock, J.M., Gilbert, I.,H., and Barrett, M.,P., (2004) Trypanocidal activity of melamine-based nitroheterocycles. Antimicrobial Agents and Chemotherapy, 48(5), pp. 1733-1738. (doi:10.1128/AAC.48.5.1733-1738.2004)

Veitch, N.V., Maugeri, D.A., Cazzulo, J.J., Lindqvist, Y., and Barrett, M.P. (2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochemical Journal, 382(2), pp. 759-767. (doi:10.1042/BJ20040459)

de Koning, H., Anderson, L., Stewart, M., Burchmore, R., Wallace, L., and Barrett, M. (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi:10.1128/AAC.48.5.1515-1519.2004)

2003

Barrett, M., Burchmore, R., Stich, A., Lazzari, J., Frasch, A., Cazzulo, J., and Krishna, S. (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi:10.1016/S0140-6736(03)14694-6)

Bray, P., Barrett, M., Ward, S., and de Koning, H. (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi:10.1016/S1471-4922(03)00069-2)

Burchmore, R., Rodriguez-Contreras, D., McBride, K., Barrett, M., Modi, G., Sacks, D., and Landfear, S. (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, R., Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M., Baldwin, S., and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi:10.1074/jbc.M301252200)

Dardonville, C., Rinaldi, E., Hanau, S., Barrett, M., Brun, R., and Gilbert, I. (2003) Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 11(14), pp. 3205-3214. (doi:10.1016/S0968-0896(03)00191-3)

Enanga, B., Ariyanayagam, M., Stewart, M., and Barrett, M. (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47(10), pp. 3368-3370. (doi:10.1128/AAC.47.10.3368-3370.2003)

Klenke, B., Barrett, M., Brun, R., and Gilbert, I. (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52(2), pp. 290-293. (doi:10.1093/jac/dkg307)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, D., Cazzulo, J., Burchmore, R., Barrett, M., and Ogbunude, P. (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi:10.1016/S0166-6851(03)00173-7)

Stich, A., Barrett, M., and Krishna, S. (2003) Waking up to sleeping sickness. Trends in Parasitology, 19(5), pp. 195-197. (doi:10.1016/S1471-4922(03)00055-2)

2002

Leslie, G., Barrett, M., and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi:10.1016/S0014-4894(03)00031-6)

Barrett, M. (2002) Perspectives for new drugs against trypanosomiasis and leishmaniasis. Current Topics in Medicinal Chemistry, 2(5), pp. 471-482. (doi:10.2174/1568026024607427)

Basselin, M., Denise, H., Coombs, G., and Barrett, M. (2002) Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrobial Agents and Chemotherapy, 46(12), pp. 3731-3738. (doi:10.1128/AAC.46.12.3731-3788.2002)

Burchmore, R., Ogbunude, P., Enanga, B., and Barrett, M. (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi:10.2174/1381612023396159)

Enanga, B., Burchmore, R., Stewart, M., and Barrett, M. (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi:10.1007/s00018-002-8472-0)

Greenblatt, C., Schnur, L., Bar-Gal, G., Ermolaev, H., Peleg, N., and Barrett, M. (2002) Polymorphism among alleles of the 6-Phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Molecular and Biochemical Parasitology, 125(1-2), pp. 185-188. (doi: 10.1016/S0166-6851(02)00213-X )

Janssen, C., Barrett, M., Turner, C., and Phillips, R. (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proceedings of the Royal Society of London Series B: Biological Sciences, 269(1800), pp. 431-436. (doi:10.1098/rspb.2001.1903)

2001

Bertelli, M., El-Bastawissy, E., Knaggs, M.H., Barrett, M.P., Hanau, S., and Gilbert, I.H. (2001) Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei. Journal of Computer-Aided Molecular Design, 15(5), pp. 465-475. (doi:10.1023/A:1011196508214)

Burchmore, R., and Barrett, M. (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi:10.1016/S0020-7519(01)00259-4)

Denise, H., and Barrett, M.P. (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology, 61(1), pp. 1-5. (doi:10.1016/S0006-2952(00)00477-9)

Janssen, C., Barrett, M., Lawson, D., Quail, M., Harris, D., Bowman, S., Phillips, R., and Turner, C. (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113(2), pp. 251-260. (doi:10.1016/S0166-6851(01)00224-9)

Klenke, B., Stewart, M., Barrett, M., Brun, R., and Gilbert, I. (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. Journal of Medicinal Chemistry, 44(21), pp. 3440-3452. (doi:10.1021/jm010854+)

2000

De Koning, H.P., MacLeod, A., Barrett, M.P., Cover, B., and Jarvis, S.M. (2000) Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology, 106(1), pp. 181-185. (doi:10.1016/S0166-6851(99)00206-6)

1999

Carter, N.S., Barrett, M.P., and De Koning, H.P. (1999) A drug resistance determinant in trypanosoma brucei. Trends in Microbiology, 7(12), pp. 469-471. (doi:10.1016/S0966-842X(99)01643-1)

This list was generated on Tue Jun 30 05:13:32 2015 BST.
Number of items: 139.

Articles

Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P., McConville, M. J., and Waters, A. P. (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi:10.1371/journal.ppat.1004882) (PMID:26042734)

Coles, J. A., Myburgh, E., Ritchie, R., Hamilton, A., Rodgers, J., Mottram, J. C., Barrett, M. P., and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi:10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi:10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

Alkhaldi, A.A.M., Creek, D.J., Ibrahim, H., Kim, D.-H., Quashie, N.B., Burgess, K.E., Changtam, C., Barrett, M.P., Suksamrarn, A., and De Koning, H.P. (2015) Potent Trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with Trypanothione. Molecular Pharmacology, 87(3), pp. 451-464. (doi:10.1124/mol.114.096016)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi:10.1093/nar/gku944)

Hai, Y., Kerkhoven, E. J., Barrett, M., and Christianson, D. W. (2015) Crystal structure of an arginase-like protein fromtrypanosoma bruceithat evolved without a binuclear manganese cluster. Biochemistry, 54(2), pp. 458-471. (doi:10.1021/bi501366a) (PMID:25536859)

van der Hooft, J., Ridder, L., Barrett, M. P., and Burgess, K. V. (2015) Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines. Frontiers in Bioengineering and Biotechnology, 3, p. 26. (doi:10.3389/fbioe.2015.00026) (PMID:25806366) (PMCID:PMC4353373)

Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P., Pellacani, C., Poli, P., and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi:10.1128/AAC.01449-13)

Achcar, F., Kerkhoven, E. J., and Barrett, M. P. (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi:10.1016/j.mib.2014.06.007)

Bourquin, Y., Syed, A., Reboud, J., Ranford-Cartwright, L. C., Barrett, M. P., and Cooper, J. M. (2014) Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angewandte Chemie, 53(22), pp. 5587-5590. (doi:10.1002/ange.201310401)

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi:10.1093/jac/dkt442)

Giordani, F., Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W., and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi:10.1128/AAC.02024-13)

Chokkathukalam, A., Kim, D.-H., Barrett, M. P., Breitling, R., and Creek, D. J. (2014) Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis, 6(4), pp. 511-524. (doi:10.4155/bio.13.348)

Kremer, C., Witte, C., Neale, S. L., Reboud, J., Barrett, M. P., and Cooper, J. M. (2014) Shape-dependent optoelectronic cell lysis. Angewandte Chemie (International Edition), 53(3), pp. 842-846. (doi:10.1002/anie.201307751) (PMID:24402800) (PMCID:PMC4441254)

Barrett, M. P., and Croft, S. L. (2014) Emerging paradigms in anti-infective drug design. Parasitology, 141(1), pp. 1-7. (doi:10.1017/S0031182013001224)

Creek, D. J., and Barrett, M. P. (2014) Determination of antiprotozoal drug mechanisms by metabolomics approaches. Parasitology, 141(1), pp. 83-92. (doi:10.1017/S0031182013000814)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi:10.1016/B978-0-12-800143-1.00003-8)

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L., and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi:10.1021/jm500483b)

Oppenheim, R. D. et al. (2014) BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens, 10(7), e1004263. (doi:10.1371/journal.ppat.1004263) (PMID:25032958) (PMCID:PMC4102578)

Trochine, A., Creek, D. J., Faral-Tello, P., Barrett, M. P., and Robello, C. (2014) Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics. PLoS Neglected Tropical Diseases, 8(5), e2844. (doi:10.1371/journal.pntd.0002844)

Munday, J.C., Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P., Morrison, L.J., and De Koning, H.P. (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi:10.1016/j.ijpddr.2013.01.004)

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi:10.1111/mmi.12351)

Achcar, F., Barrett, M.P., and Breitling, R. (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi:10.1111/febs.12436)

Barrett, M.P., Gemmell, C.G., and Suckling, C.J. (2013) Minor groove binders as anti-infective agents. Pharmacology and Therapeutics, 139(1), pp. 12-23. (doi:10.1016/j.pharmthera.2013.03.002)

Creek, D. J., Nijagal, B., Kim, D.-H., Rojas, F., Matthews, K. R., and Barrett, M. P. (2013) Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy, 57(6), pp. 2768-2779. (doi:10.1128/AAC.00044-13)

Kim, D.-H., and Barrett, M.P. (2013) Metabolite-dependent regulation of gene expression in trypanosoma brucei. Molecular Microbiology, 88(5), pp. 841-845. (doi:10.1111/mmi.12243)

Limenitakis, J., Oppenheim, R.D., Creek, D.J., Foth, B.J., Barrett, M.P., and Soldati-Favre, D. (2013) The 2-methylcitrate cycle is implicated in the detoxification of propionate inToxoplasma gondii. Molecular Microbiology, 87(4), pp. 894-908. (doi:10.1111/mmi.12139)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P., and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi:10.1093/bioinformatics/bts674)

De Muylder, G. et al. (2013) A trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathogens, 9(10), e1003731. (doi:10.1371/journal.ppat.1003731)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS ONE, 9(12), e1003371. (doi:10.1371/journal.pcbi.1003371)

Myburgh, E., Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J., Taylor, M., Barrett, M., Brewer, J., and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi:10.1371/journal.pntd.0002384)

Creek, D.J., Chokkathukalam, A., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P. (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry, 84(20), pp. 8442-8447. (doi:10.1021/ac3018795)

Clark, R.L., Clements, C.J., Barrett, M.P., Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J., and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20(20), pp. 6019-6033. (doi:10.1016/j.bmc.2012.08.049)

Baker, N., Glover, L., Munday, J. C., Aguinaga Andres, D., Barrett, M. P., De Koning, H. P., and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi:10.1073/pnas.1202885109)

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P., and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi:10.1371/journal.pcbi.1002352)

Barrett, M.P., and Croft, S.L. (2012) Management of trypanosomiasis and leishmaniasis. British Medical Bulletin, 104(1), pp. 175-196. (doi:10.1093/bmb/lds031)

Bringaud, F., Barrett, M., and Zilberstein, D. (2012) Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience, 17(1), p. 349. (doi:10.2741/3931)

Creek, D., Anderson, J., McConville, M.J., and Barrett, M.P. (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181(2), pp. 73-84. (doi:10.1016/j.molbiopara.2011.10.003)

Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P. (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28(7), pp. 1048-1049. (doi:10.1093/bioinformatics/bts069)

Menachery, A., Kremer, C., Wong, P.E., Carlsson, A., Neale, S.L., Barrett, M.P., and Cooper, J.M. (2012) Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Scientific Reports, 2(775), (doi:10.1038/srep00775)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S., and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi:10.1371/journal.pntd.0001618)

Zhang, T., Creek, D.J., Barrett, M.P., Blackburn, G., and Watson, D.G. (2012) Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry, 84(4), pp. 1994-2001. (doi:10.1021/ac2030738)

Burgess, K., Creek, D., Dewsbury, P., Cook, K., and Barrett, M.P. (2011) Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3447-3452. (doi:10.1002/rcm.5247)

Leader, D.P., Burgess, K., Creek, D., and Barrett, M.P. (2011) Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3422-3426. (doi:10.1002/rcm.5245)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N., and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi:10.2217/fmb.11.88)

Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi:10.1124/mol.111.071555)

Holm, S. H., Beech, J. P., Barrett, M. P., and Tegenfeldt, J. O. (2011) Separation of parasites from human blood using deterministic lateral displacement. Lab on a Chip, 11(7), pp. 1326-1332. (doi:10.1039/c0lc00560f)

Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P., and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi:10.1002/rcm.4939)

Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P., Wong, P.E., Male, L., Coles, S.J., and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19(5), pp. 1802-1815. (doi:10.1016/j.bmc.2011.01.010)

Brun, R., Don, R., Jacobs, R.T., Wang, M.Z., and Barrett, M.P. (2011) Development of novel drugs for human African trypanosomiasis. Future Microbiology, 6(6), pp. 677-691. (doi:10.2217/fmb.11.44)

Creek, D.J., Jankevics, A., Breitling, R., Watson, D.G., Barrett, M.P., and Burgess, K.E.V. (2011) Toward global metabolomics snalysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry, 83(22), pp. 8703-8710. (doi:10.1021/ac2021823)

Rodgers, J., Jones, A., Gibaud, S., Bradley, B., McCabe, C., Barrett, M. P., Gettinby, G., and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi:10.1371/journal.pntd.0001308)

Stoffel, S.A., Alibu, V.P., Hubert, J., Ebikeme, C., Portais, J.C., Bringaud, F., Schweingruber, M.E., and Barrett, M. (2011) Transketolase in Trypanosoma brucei. Molecular and Biochemical Parasitology, 179(1), pp. 1-7. (doi:10.1016/j.molbiopara.2011.04.006)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P., and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi:10.1128/AAC.01551-10)

Barrett, M. P. (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Current Opinion in Infectious Diseases, 23(6), pp. 603-608. (doi:10.1097/QCO.0b013e32833f9fd0)

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P., and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi:10.1074/jbc.M110.106815)

Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R., and Barrett, M.P. (2010) The silicon trypanosome. Parasitology, 137(9), pp. 1333-1341. (doi:10.1017/S0031182010000466)

Barrett, M.P., Bakker, B.M., and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137(9), pp. 1285-1290. (doi:10.1017/S003118201000017X)

Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11(8), pp. 876-883.

Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M.P., Brenk, R., and Gilbert, I. H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorganic and Medicinal Chemistry, 18(14), pp. 5056-5062. (doi:10.1016/j.bmc.2010.05.077)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343.

Conti, P., Pinto, A., Wong, P.E., Major, L.L., Tamborini, L., Iannuzzi, M.C., De Micheli, C., Barrett, M.P., and Smith, T.K. (2010) Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor. Chemmedchem, 6(2), pp. 329-333. (doi:10.1002/cmdc.201000417)

Cottret, L., Wildridge, D., Vinson, F., Barrett, M.P., Charles, H., Sagot, M.-F., and Jourdan, F. (2010) MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Research, 38(Suppl ), W132-W137. (doi:10.1093/nar/gkq312)

González, D., Pérez, J.L., Serrano, M.L., Igoillo-Esteve, M., Cazzulo, J.J., Barrett, M.P., Bubis, J., and Mendoza-León, A. (2010) The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction. Journal of Molecular Microbiology and Biotechnology, 19(4), pp. 213-223. (doi:10.1159/000320697)

Jourdan, F., Cottret, L., Huc, L., Wildridge, D., Scheltema, R., Hillenweck, A., Barrett, M.P., Zalko, D., Watson, D. G., and Debrauwer, L. (2010) Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics, 6(2), pp. 312-321. (doi:10.1007/s11306-009-0196-9)

Klee, N., Wong, P. E., Baragana, B., Mazouni, F. E., Phillips, M. A., Barrett, M.P., and Gilbert, I. H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry Letters, 20(15), pp. 4364-4366. (doi:10.1016/j.bmcl.2010.06.070)

Ruda, G.F., Wong, P.E., Alibu, V.P., Norval, S., Read, K.D., Barrett, M.P., and Gilbert, I.H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds. Journal of Medicinal Chemistry, 53(16), pp. 6071-6078. (doi:10.1021/jm1004754)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S., and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi:10.1371/journal.ppat.1001204)

Ward, C. P., Burgess, K. E.V., Burchmore, R.J.S., Barrett, M.P., and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi:10.1016/j.molbiopara.2010.07.002)

Kazibwe, A.J.N., Nerima, B., De Koning, H.P., Mäser, P., Barrett, M.P., and Matovu, E. (2009) Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases, 3(9), e523. (doi:10.1371/journal.pntd.0000523)

Mukhopadhyay, A., Chen, C.Y., Doerig, C., Henriquez, F.L., Roberts, C.W., and Barrett, M.P. (2009) The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX. Parasitology, 136(7), pp. 747-755. (doi:10.1017/S0031182009006027)

Rodgers, J., Stone, T.W., Barrett, M.P., Bradley, B.M., and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi:10.1093/brain/awp074)

Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P., and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164(2), pp. 111-117. (doi:10.1016/j.molbiopara.2008.12.007)

Wenzel, N., Wong, P.E., Maes, L., Muller, T.J., Krauth-Siegel, R.L., Barrett, M.P., and Davioud-Charvet, E. (2009) Unsaturated mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4(3), pp. 339-351. (doi:10.1002/cmdc.200800360)

Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M.P., and Gilbert, I.H. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic and Biomolecular Chemistry, 7(6), pp. 1154-1166. (doi:10.1039/b813394h)

Chollet, C., Baliani, A., Wong, P.E., Barrett, M.P., and Gilbert, I.H. (2009) Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry, 17(6), pp. 2512-2523. (doi:10.1016/j.bmc.2009.01.058)

Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P., Wilson, W.D., and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284(49), pp. 34028-34035. (doi:10.1074/jbc.M109.049726)

Scheltema, R.A., Kamleh, A., Wildridge, D., Ebikeme, C., Watson, D.G., Barrett, M., Jansen, R.C., and Breitling, R. (2008) Increasing the mass accuracy of high-resolution LC-MS data using background ions - a case study on the LTQ-Orbitrap. Proteomics, 8(22), pp. 4647-4656. (doi:10.1002/pmic.200800314)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.., and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi:10.1002/rcm.3564)

Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P., Franconi, J.M., and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283(24), pp. 16342-16354. (doi:10.1074/jbc.M709592200)

Ebikeme, C.E., Peacock, L., Coustou, V., Riviere, L., Bringaud, F., Gibson, W.C., and Barrett, M.P. (2008) N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology, 135(5), pp. 585-594. (doi:10.1017/S0031182008004241)

Checchi, F., and Barrett, M.P. (2008) African sleeping sicknesss - Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored. British Medical Journal, 336(7646), pp. 679-680. (doi:10.1136/bmj.39505.490544.BE)

Breitling, R., Vitkup, D., and Barrett, M.P. (2008) New surveyor tools for charting microbial metabolic maps. Nature Reviews Microbiology, 6, pp. 156-161. (doi:10.1038/nrmicro1797)

Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J., and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18(7), pp. 2455-2458. (doi:10.1016/j.bmcl.2008.02.037)

Arrighi, R. B. G., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L.C., Barrett, M.P., Langel, U., and Faye, I. (2008) Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrobial Agents and Chemotherapy, 52(9), pp. 3414-3417. (doi:10.1128/AAC.01450-07)

Checchi, F., Filipe, J.A.N., Barrett, M.P., and Chandramohan, D. (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS Neglected Tropical Diseases, 2(12), e303. (doi:10.1371/journal.pntd.0000303)

Jourdan, F., Breitling, R., Barrett, M.P., and Gilbert, D. (2008) MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics, 24(1), pp. 143-145. (doi:10.1093/bioinformatics/btm536)

Reid, C. M., Ebikeme, C., Barrett, M.P., Patzewitz, E.-M., Muller, S., Robins, D. J., and Sutherland, A. (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi:10.1016/j.bmcl.2008.09.047)

Sundaramoorthy, R., Iulek, J., Barrett, M. P., Bidet, O., Ruda, G. F., Gilbert, I. H., and Hunter, W. N. (2007) Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. FEBS Journal, 274(1), pp. 275-286. (doi:10.1111/j.1742-4658.2006.05585.x)

Barrett, M. (2007) Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology, 152(8), pp. 1155-1171. (doi:10.1038/sj.bjp.0707354)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S., and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Ogbunude, P., Lamour, N., and Barrett, M. (2007) Molecular cloning, expression and characterization of ribokinase of Leishmania major. Acta Biochimica et Biophysica Sinica, 39, pp. 462-466. (doi:10.1111/j.1745-7270.2007.00298.x)

Anene, B.M., Ezeokonkwo, R.C., Mmesirionye, T.I., Tettey, J.N.A., Brock, J.M., Barrett, M.P., and De Koning, H.P. (2006) A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 132(1), pp. 127-133. (doi:10.1017/S0031182005008760)

Barrett, M., and Gilbert, I. (2006) Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology, 63, pp. 125-183. (doi:10.1016/S0065-308X(06)63002-9)

Breitling, R., Ritchie, S., Goodenowe, D., Stewart, M., and Barrett, M. (2006) Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data. Metabolomics, 2, pp. 155-164. (doi:10.1007/s11306-006-0029-z)

Dardonville, C., Barrett, M., Brun, R., Kaiser, M., Tanious, F., and Wilson, W. (2006) DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. Journal of Medicinal Chemistry, 49, pp. 3748-3752. (doi:10.1021/jm060295c)

Lanteri, C.A., Stewart, M.L., Brock, J.M., Alibu, V.P., Meshnick, S.R., Tidwell, R.R., and Barrett, M.P. (2006) Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology, 70(5), pp. 1585-1592. (doi:10.1124/mol.106.024653)

Mukherjee, A., Padmanabhan, P., Sahani, M., Barrett, M., and Madhubala, R. (2006) Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145, pp. 1-10. (doi:10.1016/j.molbiopara.2005.08.016)

Baliani, A., Bueno, G., Stewart, M., Yardley, V., Brun, R., Barrett, M., and Gilbert, I. (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. Journal of Medicinal Chemistry, 48, pp. 5570-5579. (doi:10.1021/jm050177+)

Besteiro, S., Barrett, M., Riviere, L., and Bringaud, F. (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends in Parasitology, 21, pp. 185-191.

Croft, S., Barrett, M., and Urbina, J. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends in Parasitology, 21, pp. 508-512. (doi:10.1016/j.pt.2005.08.026)

Lamour, N., Riviere, L., Coustou, V., Coombs, G., Barrett, M., and Bringaud, F. (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280, pp. 11902-11910. (doi:10.1074/jbc.M414274200)

Stewart, M., Boussard, C., Brun, R., Gilbert, I., and Barrett, M. (2005) Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter. Antimicrobial Agents and Chemotherapy, 49, pp. 5169-5171. (doi:10.1128/AAC.49.12.5169-5171.2005)

Stewart, M., Krishna, S., Burchmore, R., Brun, R., de Koning, H., Boykin, D., Tidwell, R., Hall, J., and Barrett, M. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi:10.1016/S0140-6736(05)66793-1)

Janssen, C.S., Phillips, R.S., Turner, C., and Barrett, M.P. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32(19), pp. 5712-5720. (doi:10.1093/nar/gkh907)

Azema, L. et al. (2004) Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochemical Pharmacology, 67, pp. 459-467. (doi:10.1016/j.bcp.2003.09.005)

Dardonville, C., Rinaldi, E., Barrett, M., Brun, R., Gilbert, I., and Hanau, S. (2004) Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. Journal of Medicinal Chemistry, 47, pp. 3427-3437. (doi:10.1021/jm031066i)

Hanau, S., Rinaldi, E., Dallocchio, F., Gilbert, I., Dardonville, C., Adams, M., Gover, S., and Barrett, M. (2004) 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes. Current Medicinal Chemistry, 11, pp. 2639-2650.

Janssen, C., Phillips, R., Turner, C., and Barrett, M. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32, pp. 5712-5720. (doi:10.1093/nar/gkh907)

Stewart, M.L., Bueno, G.J., Baliani, A., Klenke, B., Brun, R., Brock, J.M., Gilbert, I.,H., and Barrett, M.,P., (2004) Trypanocidal activity of melamine-based nitroheterocycles. Antimicrobial Agents and Chemotherapy, 48(5), pp. 1733-1738. (doi:10.1128/AAC.48.5.1733-1738.2004)

Veitch, N.V., Maugeri, D.A., Cazzulo, J.J., Lindqvist, Y., and Barrett, M.P. (2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochemical Journal, 382(2), pp. 759-767. (doi:10.1042/BJ20040459)

de Koning, H., Anderson, L., Stewart, M., Burchmore, R., Wallace, L., and Barrett, M. (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi:10.1128/AAC.48.5.1515-1519.2004)

Barrett, M., Burchmore, R., Stich, A., Lazzari, J., Frasch, A., Cazzulo, J., and Krishna, S. (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi:10.1016/S0140-6736(03)14694-6)

Bray, P., Barrett, M., Ward, S., and de Koning, H. (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi:10.1016/S1471-4922(03)00069-2)

Burchmore, R., Rodriguez-Contreras, D., McBride, K., Barrett, M., Modi, G., Sacks, D., and Landfear, S. (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, R., Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M., Baldwin, S., and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi:10.1074/jbc.M301252200)

Dardonville, C., Rinaldi, E., Hanau, S., Barrett, M., Brun, R., and Gilbert, I. (2003) Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 11(14), pp. 3205-3214. (doi:10.1016/S0968-0896(03)00191-3)

Enanga, B., Ariyanayagam, M., Stewart, M., and Barrett, M. (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47(10), pp. 3368-3370. (doi:10.1128/AAC.47.10.3368-3370.2003)

Klenke, B., Barrett, M., Brun, R., and Gilbert, I. (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52(2), pp. 290-293. (doi:10.1093/jac/dkg307)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, D., Cazzulo, J., Burchmore, R., Barrett, M., and Ogbunude, P. (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi:10.1016/S0166-6851(03)00173-7)

Stich, A., Barrett, M., and Krishna, S. (2003) Waking up to sleeping sickness. Trends in Parasitology, 19(5), pp. 195-197. (doi:10.1016/S1471-4922(03)00055-2)

Leslie, G., Barrett, M., and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi:10.1016/S0014-4894(03)00031-6)

Barrett, M. (2002) Perspectives for new drugs against trypanosomiasis and leishmaniasis. Current Topics in Medicinal Chemistry, 2(5), pp. 471-482. (doi:10.2174/1568026024607427)

Basselin, M., Denise, H., Coombs, G., and Barrett, M. (2002) Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrobial Agents and Chemotherapy, 46(12), pp. 3731-3738. (doi:10.1128/AAC.46.12.3731-3788.2002)

Burchmore, R., Ogbunude, P., Enanga, B., and Barrett, M. (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi:10.2174/1381612023396159)

Enanga, B., Burchmore, R., Stewart, M., and Barrett, M. (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi:10.1007/s00018-002-8472-0)

Greenblatt, C., Schnur, L., Bar-Gal, G., Ermolaev, H., Peleg, N., and Barrett, M. (2002) Polymorphism among alleles of the 6-Phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Molecular and Biochemical Parasitology, 125(1-2), pp. 185-188. (doi: 10.1016/S0166-6851(02)00213-X )

Janssen, C., Barrett, M., Turner, C., and Phillips, R. (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proceedings of the Royal Society of London Series B: Biological Sciences, 269(1800), pp. 431-436. (doi:10.1098/rspb.2001.1903)

Bertelli, M., El-Bastawissy, E., Knaggs, M.H., Barrett, M.P., Hanau, S., and Gilbert, I.H. (2001) Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei. Journal of Computer-Aided Molecular Design, 15(5), pp. 465-475. (doi:10.1023/A:1011196508214)

Burchmore, R., and Barrett, M. (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi:10.1016/S0020-7519(01)00259-4)

Denise, H., and Barrett, M.P. (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology, 61(1), pp. 1-5. (doi:10.1016/S0006-2952(00)00477-9)

Janssen, C., Barrett, M., Lawson, D., Quail, M., Harris, D., Bowman, S., Phillips, R., and Turner, C. (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113(2), pp. 251-260. (doi:10.1016/S0166-6851(01)00224-9)

Klenke, B., Stewart, M., Barrett, M., Brun, R., and Gilbert, I. (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. Journal of Medicinal Chemistry, 44(21), pp. 3440-3452. (doi:10.1021/jm010854+)

De Koning, H.P., MacLeod, A., Barrett, M.P., Cover, B., and Jarvis, S.M. (2000) Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology, 106(1), pp. 181-185. (doi:10.1016/S0166-6851(99)00206-6)

Carter, N.S., Barrett, M.P., and De Koning, H.P. (1999) A drug resistance determinant in trypanosoma brucei. Trends in Microbiology, 7(12), pp. 469-471. (doi:10.1016/S0966-842X(99)01643-1)

Book Sections

Giordani, F., Mwenechanya, R., and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan , S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi:10.1016/B978-0-12-386882-4.00039-6)

Creek, D.J., Vincent, I.M., and Barrett, M.P. (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi:10.1002/9783527670383.ch3)

Rogers, S., Scheltema, R.A., Barrett, M., and Breitling, R. (2011) Bayesian approaches for mass spectrometry-based metabolomics. In: Stumpf, M.P.H., Balding, D.J. and Girolami, M. (eds.) Handbook of Statistical Systems Biology. John Wiley & Sons: Chichester, UK, pp. 467-476. ISBN 9780470710869 (doi:10.1002/9781119970606.ch24)

This list was generated on Tue Jun 30 05:13:32 2015 BST.