2013

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P., and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29 (2). pp. 281-283. ISSN 1367-4803 (doi:10.1093/bioinformatics/bts674)

2012

Creek, D.J., Chokkathukalam, A., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P. (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry, 84 (20). pp. 8442-8447. ISSN 0003-2700 (doi:10.1021/ac3018795)

Clark, R.L., Clements, C.J., Barrett, M.P., Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J., and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20 (20). pp. 6019-6033. ISSN 0968-0896 (doi:10.1016/j.bmc.2012.08.049)

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P., and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8 (1). e1002352. ISSN 1553-734X (doi:10.1371/journal.pcbi.1002352)

Baker, N., Glover, L., Munday, J.C., Aguinaga Andres, D., Barrett, M.P., De Koning, H.P., and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109 (27). pp. 10996-11001. ISSN 0027-8424 (doi:10.1073/pnas.1202885109)

Barrett, M.P., and Croft, S.L. (2012) Management of trypanosomiasis and leishmaniasis. British Medical Bulletin, 104 (1). pp. 175-196. ISSN 0007-1420 (doi:10.1093/bmb/lds031)

Bringaud, F., Barrett, M., and Zilberstein, D. (2012) Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience, 17 (1). p. 349. ISSN 1093-9946 (doi:10.2741/3931)

Creek, D., Anderson, J., McConville, M.J., and Barrett, M.P. (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181 (2). pp. 73-84. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2011.10.003)

Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P. (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28 (7). pp. 1048-1049. ISSN 1367-4803 (doi:10.1093/bioinformatics/bts069)

Menachery, A., Kremer, C., Wong, P.E., Carlsson, A., Neale, S.L., Barrett, M.P., and Cooper, J.M. (2012) Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Scientific Reports, 2 (775). (doi:10.1038/srep00775)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S., and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6 (5). e1618. ISSN 1935-2727 (doi:10.1371/journal.pntd.0001618)

Zhang, T., Creek, D.J., Barrett, M.P., Blackburn, G., and Watson, D.G. (2012) Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry, 84 (4). pp. 1994-2001. ISSN 0003-2700 (doi:10.1021/ac2030738)

2011

Burgess, K., Creek, D., Dewsbury, P., Cook, K., and Barrett, M.P. (2011) Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 25 (22). pp. 3447-3452. ISSN 0951-4198 (doi:10.1002/rcm.5247)

Leader, D.P., Burgess, K., Creek, D., and Barrett, M.P. (2011) Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry, 25 (22). pp. 3422-3426. ISSN 0951-4198 (doi:10.1002/rcm.5245)

Rodgers, J., Jones, A., Gibaud, S., Bradley, B., McCabe, C., Barrett, M.P., Gettinby, G., and Kennedy, P.G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5 (9). e1308. ISSN 1935-2727 (doi:10.1371/journal.pntd.0001308)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N., and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6 (9). pp. 1037-1047. ISSN 1746-0913 (doi:10.2217/fmb.11.88)

Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P., and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25 (7). pp. 969-972. ISSN 0951-4198 (doi:10.1002/rcm.4939)

Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P., Wong, P.E., Male, L., Coles, S.J., and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:10.1016/j.bmc.2011.01.010)

Brun, R., Don, R., Jacobs, R.T., Wang, M.Z., and Barrett, M.P. (2011) Development of novel drugs for human African trypanosomiasis. Future Microbiology, 6 (6). pp. 677-691. ISSN 1746-0913 (doi:10.2217/fmb.11.44)

Creek, D.J., Jankevics, A., Breitling, R., Watson, D.G., Barrett, M.P., and Burgess, K.E.V. (2011) Toward global metabolomics snalysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry, 83 (22). pp. 8703-8710. ISSN 0003-2700 (doi:10.1021/ac2021823)

Holm, S.H., Beech, J.P., Barrett, M.P., and Tegenfeldt, J.O. (2011) Separation of parasites from human blood using deterministic lateral displacement. Lab On a Chip, 11 (7). pp. 1326-1332. ISSN 1473-0197 (doi:10.1039/c0lc00560f)

Rogers, S., Scheltema, R.A., Barrett, M., and Breitling, R. (2011) Bayesian approaches for mass spectrometry-based metabolomics. In: Stumpf, M.P.H., Balding, D.J. and Girolami, M. (eds.) Handbook of Statistical Systems Biology. John Wiley & Sons, Chichester, UK, pp. 467-476. ISBN 9780470710869

Stoffel, S.A., Alibu, V.P., Hubert, J., Ebikeme, C., Portais, J.C., Bringaud, F., Schweingruber, M.E., and Barrett, M. (2011) Transketolase in Trypanosoma brucei. Molecular and Biochemical Parasitology, 179 (1). pp. 1-7. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2011.04.006)

Teka, I.A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80 (1). pp. 110-116. ISSN 0026-895X (doi:10.1124/mol.111.071555)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P., and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55 (5). pp. 2352-2361. ISSN 0066-4804 (doi:10.1128/AAC.01551-10)

2010

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P., and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285 (39). pp. 29721-29728. ISSN 0021-9258 (doi:10.1074/jbc.M110.106815)

Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R., and Barrett, M.P. (2010) The silicon trypanosome. Parasitology, 137 (9). pp. 1333-1341. ISSN 0031-1820 (doi:10.1017/S0031182010000466)

Barrett, M.P., Bakker, B.M., and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137 (9). pp. 1285-1290. ISSN 0031-1820 (doi:10.1017/S003118201000017X)

Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11 (8). pp. 876-883. ISSN 1472-4472

Ruda, Gian Filippo, Campbell, Gordon, Alibu, Vincent P., Barrett, M.P., Brenk, Ruth, and Gilbert, Ian H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorganic and Medicinal Chemistry, 18 (14). pp. 5056-5062. ISSN 0968-0896 (doi:10.1016/j.bmc.2010.05.077)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9 (2). pp. 336-343. ISSN 1535-9778

Barrett, M.P. (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Current Opinion in Infectious Diseases, 23 (6). pp. 603-608. ISSN 0951-7375 (doi:10.1097/QCO.0b013e32833f9fd0)

Conti, P., Pinto, A., Wong, P.E., Major, L.L., Tamborini, L., Iannuzzi, M.C., De Micheli, C., Barrett, M.P., and Smith, T.K. (2010) Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor. Chemmedchem, 6 (2). pp. 329-333. ISSN 1860-7179 (doi:10.1002/cmdc.201000417)

Cottret, L., Wildridge, D., Vinson, F., Barrett, M.P., Charles, H., Sagot, M.-F., and Jourdan, F. (2010) MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Research, 38 (Suppl ). W132-W137. ISSN 0305-1048 (doi:10.1093/nar/gkq312)

González, D., Pérez, J.L., Serrano, M.L., Igoillo-Esteve, M., Cazzulo, J.J., Barrett, M.P., Bubis, J., and Mendoza-León, A. (2010) The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction. Journal of Molecular Microbiology and Biotechnology, 19 (4). pp. 213-223. ISSN 1464-1801 (doi:10.1159/000320697)

Jourdan, Fabien, Cottret, Ludovic, Huc, Laurence, Wildridge, David, Scheltema, Richard, Hillenweck, Anne, Barrett, M.P., Zalko, Daniel, Watson, David G., and Debrauwer, Laurent (2010) Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics, 6 (2). pp. 312-321. ISSN 1573-3882 (doi:10.1007/s11306-009-0196-9)

Klee, Nina, Wong, Pui Ee, Baragana, Beatriz, Mazouni, Farah El, Phillips, Margaret A., Barrett, M.P., and Gilbert, Ian H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry Letters, 20 (15). pp. 4364-4366. ISSN 0960-894X (doi:10.1016/j.bmcl.2010.06.070)

Ruda, G.F., Wong, P.E., Alibu, V.P., Norval, S., Read, K.D., Barrett, M.P., and Gilbert, I.H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds. Journal of Medicinal Chemistry, 53 (16). pp. 6071-6078. ISSN 0022-2623 (doi:10.1021/jm1004754)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S., and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6 (11). e1001204. ISSN 1553-7366 (doi:10.1371/journal.ppat.1001204)

Ward, Christopher P., Burgess, Karl E.V., Burchmore, R.J.S., Barrett, M.P., and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174 (2). pp. 145-149. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2010.07.002)

2009

Kazibwe, A.J.N., Nerima, B., De Koning, H.P., Mäser, P., Barrett, M.P., and Matovu, E. (2009) Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases, 3 (9). e523. ISSN 1935-2727 (doi:10.1371/journal.pntd.0000523)

Mukhopadhyay, A., Chen, C.Y., Doerig, C., Henriquez, F.L., Roberts, C.W., and Barrett, M.P. (2009) The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX. Parasitology, 136 (7). pp. 747-755. ISSN 0031-1820 (doi:10.1017/S0031182009006027)

Rodgers, J., Stone, T.W., Barrett, M.P., Bradley, B.M., and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132 (5). pp. 1259-1267. ISSN 0006-8950 (doi:10.1093/brain/awp074)

Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P., and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164 (2). pp. 111-117. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2008.12.007)

Wenzel, N., Wong, P.E., Maes, L., Muller, T.J., Krauth-Siegel, R.L., Barrett, M.P., and Davioud-Charvet, E. (2009) Unsaturated mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4 (3). pp. 339-351. ISSN 1860-7179 (doi:10.1002/cmdc.200800360)

Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M.P., and Gilbert, I.H. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic and Biomolecular Chemistry, 7 (6). pp. 1154-1166. ISSN 1477-0520 (doi:10.1039/b813394h)

Chollet, C., Baliani, A., Wong, P.E., Barrett, M.P., and Gilbert, I.H. (2009) Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry, 17 (6). pp. 2512-2523. ISSN 0968-0896 (doi:10.1016/j.bmc.2009.01.058)

Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P., Wilson, W.D., and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284 (49). pp. 34028-34035. ISSN 0021-9258 (doi:10.1074/jbc.M109.049726)

2008

Scheltema, R.A., Kamleh, A., Wildridge, D., Ebikeme, C., Watson, D.G., Barrett, M., Jansen, R.C., and Breitling, R. (2008) Increasing the mass accuracy of high-resolution LC-MS data using background ions - a case study on the LTQ-Orbitrap. Proteomics, 8 (22). pp. 4647-4656. ISSN 1615-9853 (doi:10.1002/pmic.200800314)

Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P., Franconi, J.M., and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283 (24). pp. 16342-16354. ISSN 0021-9258 (doi:10.1074/jbc.M709592200)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.., and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22 (12). pp. 1912-1918. ISSN 0951-4198 (doi:10.1002/rcm.3564)

Ebikeme, C.E., Peacock, L., Coustou, V., Riviere, L., Bringaud, F., Gibson, W.C., and Barrett, M.P. (2008) N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology, 135 (5). pp. 585-594. ISSN 0031-1820 (doi:10.1017/S0031182008004241)

Checchi, F., and Barrett, M.P. (2008) African sleeping sicknesss - Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored. British Medical Journal, 336 (7646). pp. 679-680. ISSN 0959-535X (doi:10.1136/bmj.39505.490544.BE)

Breitling, R., Vitkup, D., and Barrett, M.P. (2008) New surveyor tools for charting microbial metabolic maps. Nature Reviews Microbiology, 6 . pp. 156-161. ISSN 1740-1526 (doi:10.1038/nrmicro1797)

Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J., and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18 (7). pp. 2455-2458. ISSN 0960-894X (doi:10.1016/j.bmcl.2008.02.037)

Arrighi, R. B. G., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L.C., Barrett, M.P., Langel, U., and Faye, I. (2008) Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrobial Agents and Chemotherapy, 52 (9). pp. 3414-3417. ISSN 0066-4804 (doi:10.1128/AAC.01450-07)

Checchi, F., Filipe, J.A.N., Barrett, M.P., and Chandramohan, D. (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS Neglected Tropical Diseases, 2 (12). e303. ISSN 1935-2727 (doi:10.1371/journal.pntd.0000303)

Jourdan, F., Breitling, R., Barrett, M.P., and Gilbert, D. (2008) MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics, 24 (1). pp. 143-145. ISSN 1367-4803 (doi:10.1093/bioinformatics/btm536)

Reid, Caroline M., Ebikeme, Charles, Barrett, M.P., Patzewitz, Eva-Maria, Muller, S., Robins, David J., and Sutherland, Andrew (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18 (20). pp. 5399-5401. ISSN 0960894X (doi:10.1016/j.bmcl.2008.09.047)

2007

Barrett, M (2007) Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology, 152 (8). pp. 1155-1171. (doi:10.1038/sj.bjp.0707354)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S., and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70 (6). pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Ogbunude, POJ, Lamour, N, and Barrett, MP (2007) Molecular cloning, expression and characterization of ribokinase of Leishmania major. Acta Biochimica et Biophysica Sinica, 39 . pp. 462-466. (doi:10.1111/j.1745-7270.2007.00298.x)

Sundaramoorthy, R, Iulek, J, Barrett, MP, Bidet, O, Ruda, GF, Gilbert, IH, and Hunter, WN (2007) Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. Febs Journal, 274 . pp. 275-286. (doi:10.1111/j.1742-4658.2006.05585.x)

2006

Anene, BM, Ezeokonkwo, RC, Mmesirionye, TI, Tettey, JNA, Brock, JM, Barrett, MP, and De Koning, HP (2006) A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 132 . pp. 127-133. (doi:10.1017/S0031182005008760)

Barrett, MP, and Gilbert, IH (2006) Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology, 63 . pp. 125-183. (doi:10.1016/S0065-308X(06)63002-9)

Breitling, R, Ritchie, S, Goodenowe, D, Stewart, ML, and Barrett, MP (2006) Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data. Metabolomics, 2 . pp. 155-164. (doi:10.1007/s11306-006-0029-z)

Dardonville, C, Barrett, MP, Brun, R, Kaiser, M, Tanious, F, and Wilson, WD (2006) DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. Journal of Medicinal Chemistry, 49 . pp. 3748-3752. (doi:10.1021/jm060295c)

Lanteri, CA, Stewart, ML, Brock, JM, Alibu, VP, Meshnick, SR, Tidwell, RR, and Barrett, MP (2006) Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology, 70 . pp. 1585-1592. (doi:10.1124/mol.106.024653)

Mukherjee, A, Padmanabhan, PK, Sahani, MH, Barrett, MP, and Madhubala, R (2006) Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145 . pp. 1-10. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2005.08.016)

2005

Baliani, A, Bueno, GJ, Stewart, ML, Yardley, V, Brun, R, Barrett, MP, and Gilbert, IH (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. Journal of Medicinal Chemistry, 48 . pp. 5570-5579. (doi:10.1021/jm050177+)

Besteiro, S, Barrett, MP, Riviere, L, and Bringaud, F (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends in Parasitology, 21 . pp. 185-191.

Croft, SL, Barrett, MP, and Urbina, JA (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends in Parasitology, 21 . pp. 508-512. (doi:10.1016/j.pt.2005.08.026)

Lamour, N, Riviere, L, Coustou, V, Coombs, GH, Barrett, MP, and Bringaud, F (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280 . pp. 11902-11910. ISSN 0021-9258 (doi:10.1074/jbc.M414274200)

Stewart, ML, Boussard, C, Brun, R, Gilbert, IH, and Barrett, MP (2005) Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter. Antimicrobial Agents and Chemotherapy, 49 . pp. 5169-5171. ISSN 0066-4804 (doi:10.1128/AAC.49.12.5169-5171.2005)

Stewart, ML, Krishna, S, Burchmore, RJS, Brun, R, de Koning, HP, Boykin, DW, Tidwell, RR, Hall, JE, and Barrett, MP (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366 . pp. 486-487. ISSN 0140-6736 (doi:10.1016/S0140-6736(05)66793-1)

2004

Janssen, C.S., Phillips, R.S., Turner, Charles, and Barrett, M.P. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32 (19). pp. 5712-5720. ISSN 0305-1048 (doi:10.1093/nar/gkh907)

Azema, L et al. (2004) Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochemical Pharmacology, 67 . pp. 459-467. (doi:10.1016/j.bcp.2003.09.005)

Dardonville, C, Rinaldi, E, Barrett, MP, Brun, R, Gilbert, IH, and Hanau, S (2004) Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. Journal of Medicinal Chemistry, 47 . pp. 3427-3437. (doi:10.1021/jm031066i)

Hanau, S, Rinaldi, E, Dallocchio, F, Gilbert, IH, Dardonville, C, Adams, MJ, Gover, S, and Barrett, MP (2004) 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes. Current Medicinal Chemistry, 11 . pp. 2639-2650.

Janssen, CS, Phillips, RS, Turner, CMR, and Barrett, MP (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32 . pp. 5712-5720. (doi:10.1093/nar/gkh907)

Stewart, ML, Bueno, GJ, Baliani, A, Klenke, B, Brun, R, Brock, JM, Gilbert, IH, and Barrett, MP (2004) Trypanocidal activity of melamine-based nitroheterocycles. Antimicrobial Agents and Chemotherapy, 48 . pp. 1733-1738. ISSN 0066-4804 (doi:10.1128/AAC.48.5.1733-1738.2004)

Veitch, N.V., Maugeri, D.A., Cazzulo, J.J., Lindqvist, Y., and Barrett, M.P. (2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochemical Journal, 382 (2). pp. 759-767. ISSN 0264-6021 (doi:10.1042/BJ20040459)

de Koning, HP, Anderson, LF, Stewart, M, Burchmore, RJS, Wallace, LJM, and Barrett, MP (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48 . pp. 1515-1519. ISSN 0066-4804 (doi:10.1128/AAC.48.5.1515-1519.2004)

2003

Barrett, MP, Burchmore, RJS, Stich, A, Lazzari, JO, Frasch, AC, Cazzulo, JJ, and Krishna, S (2003) The trypanosomiases. Lancet, 362 . pp. 1469-1480.

Bray, PG, Barrett, MP, Ward, SA, and de Koning, HP (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19 . pp. 232-239. (doi:10.1016/S1471-4922(03)00069-2)

Burchmore, RJS, Rodriguez-Contreras, D, McBride, K, Barrett, MP, Modi, G, Sacks, D, and Landfear, SM (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100 . pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, RJS, Wallace, LJM, Candlish, D, Al-Salabi, MI, Beal, PR, Barrett, MP, Baldwin, SA, and de Koning, HP (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278 . pp. 23502-23507. ISSN 0021-9258 (doi:10.1074/jbc.M301252200)

Dardonville, C, Rinaldi, E, Hanau, S, Barrett, MP, Brun, R, and Gilbert, IH (2003) Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorganic and Medicinal Chemistry, 11 . pp. 3205-3214. (doi:10.1016/S0968-0896(03)00191-3)

Enanga, B, Ariyanayagam, MR, Stewart, ML, and Barrett, MP (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47 . pp. 3368-3370. ISSN 0066-4804 (doi:10.1128/AAC.47.10.3368-3370.2003)

Klenke, B, Barrett, MP, Brun, R, and Gilbert, IH (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52 . pp. 290-293. (doi:10.1093/jac/dkg307)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2 (5). pp. 1003-1008. ISSN 1535-9778 (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, DA, Cazzulo, JJ, Burchmore, RJS, Barrett, MP, and Ogbunude, POJ (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130 . pp. 117-125. ISSN 0166-6851 (doi:10.1016/S0166-6851(03)00173-7)

Stich, A, Barrett, MP, and Krishna, S (2003) Waking up to sleeping sickness. Trends in Parasitology, 19 . pp. 195-197. (doi:10.1016/S1471-4922(03)00055-2)

2002

Leslie, G., Barrett, M., and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102 (2). pp. 117-120. ISSN 0014-4894 (doi:10.1016/S0014-4894(03)00031-6)

Barrett, M (2002) Perspectives for new drugs against trypanosomiasis and leishmaniasis. Current Topics in Medicinal Chemistry, 2 (5). pp. 471-482. (doi:10.2174/1568026024607427)

Basselin, M, Denise, H, Coombs, GH, and Barrett, MP (2002) Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrobial Agents and Chemotherapy, 46 . pp. 3731-3738. ISSN 0066-4804 (doi:10.1128/AAC.46.12.3731-3788.2002)

Burchmore, RJS, Ogbunude, POJ, Enanga, B, and Barrett, MP (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8 . pp. 257-267.

Enanga, B, Burchmore, RJS, Stewart, ML, and Barrett, MP (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59 . pp. 845-858.

Greenblatt, CL, Schnur, LF, Bar-Gal, GK, Ermolaev, H, Peleg, N, and Barrett, MP (2002) Polymorphism among alleles of the 6-Phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Molecular and Biochemical Parasitology, 125 . pp. 185-188. ISSN 0166-6851

Janssen, CS, Barrett, MP, Turner, CMR, and Phillips, RS (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proceedings of the Royal Society of London Series B: Biological Sciences, 269 . pp. 431-436. ISSN 0962-8452 (doi:10.1098/rspb.2001.1903)

2001

Bertelli, M., El-Bastawissy, E., Knaggs, M.H., Barrett, M.P., Hanau, S., and Gilbert, I.H. (2001) Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei. Journal of Computer-Aided Molecular Design, 15 . pp. 465-475.

Burchmore, RJS, and Barrett, MP (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal For Parasitology, 31 . pp. 1311-1320.

Denise, H, and Barrett, MP (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology, 61 . pp. 1-5.

Janssen, CS, Barrett, MP, Lawson, D, Quail, MA, Harris, D, Bowman, S, Phillips, RS, and Turner, CMR (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113 . pp. 251-260. ISSN 0166-6851

Klenke, B, Stewart, M, Barrett, MP, Brun, R, and Gilbert, IH (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. Journal of Medicinal Chemistry, 44 . pp. 3440-3452. (doi:10.1021/jm010854+)