Dr Megan MacLeod

  • Research Fellow (Immunology)

telephone: 0141 330 6629
email: Megan.Macleod@glasgow.ac.uk

Research interests

Research in my lab is focussed on understanding the underlying differences between naïve and memory CD4 T cells. CD4 T cells are the orchestrators of the immune system, directing and controlling many other immune cell types. Memory CD4 T cells develop following an adaptive immune response and can act more quickly and effectively to direct a secondary immune attack. However, these superior immune responses require tight regulation of memory CD4 T cell activity. In autoimmune diseases such as rheumatoid arthritis, memory or activated CD4 T cells are thought to coordinate the inappropriate cellular infiltration into joints that causes bone damage and chronic pain.

The major goal of our research is to understand the cellular and molecular differences that enable memory CD4 T cells to respond differently from their naïve counterparts. Thus, we will be able to open new avenues to improve their responses in vaccination and inhibit them in autoimmune diseases.

Details of Public Engagement Activities

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating The Molecular Basis for Stromal Memory Following Influenza Virus Infection (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • CD4INEar: Defining the cellular interactions that control the retention of and tolerance induction in CD4 T cells at inflammatory sites
    European Commission
    2014 - 2017
     
  • Characterisation of a novel transgenic mouse for the detection of pathogen specific memory CD4 T cells
    Tenovus-Scotland
    2012 - 2013
     
  • Molecular requirements for the induction of tolerance in activated and memory CD4 T cells.
    Arthritis Research UK
    2012 - 2017
     

Additional information

Prizes, Awards and Distinctions

  • 2014: Wellcome Trust - Silent Signal: An Arts/Science collaborative project co-funded by Animate Projects and the Wellcome Trust. Dr Macleod is working with artist Eric Schockmel to create 'The Garden of Synthetic Delights' a 'design-futures' based concept animation that incorporates the ideas of T cell differentiation and immune-protection. http://www.silentsignal.org/the-garden-of-synthetic-delights/
  • 2014: Glasgow Science Centre - Meet the Expert at the Glasgow Science Centre. 'Friendly Fire: how the immune system goes off target and causes autoimmune disease'. This event is the perfect opportunity for scientists to engage with the public's interest in science. Dr Macleod and colleagues brought glitter and stickers to the Glasgow Science Centre. While getting glitter everywhere, they explained what the immune system is for and how, sometimes, it can go "off target" causing autoimmune disease like rheumatoid arthritis.

Publications

List by: Type | Date

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2003 | 2002
Number of items: 22.

2013

Huang, Y. et al. (2013) Antigen-specific regulation of IgE antibodies by non-antigen-specific T cells. Journal of Immunology, 190 (3). pp. 913-921. (doi:10.4049/jimmunol.1202230)

Macleod, M.K.L., David, A., Jin, N., Noges, L., Wang, J., Kappler, J.W., and Marrack, P. (2013) Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence. PLoS ONE, 8 (4). e61775. (doi:10.1371/journal.pone.0061775)

2012

Aviszus, K., Macleod, M., Kirchenbaum, G.A., Detanico, D.O., Heiser, R.A., St. Clair, J.B., Guo, W.J., and Wysocki, L.J. (2012) Antigen specific suppression of humoral immunity by anergic Ars/A1 B cells. Journal of Immunology, 189 (9). pp. 4275-4283.

Bosio, C.M., Macleod, M., Marrack, P., and Kedl, R.M. (2012) Utility of mouse models in vaccine design and development. In: Morrow, W.J.W., Sheikh, N.A., Schmidt , C.S. and Davies, H. (eds.) Vaccinology: Principles and Practices. Wiley-Blackwell, Chichester, UK. ISBN 9781405185745

2011

MacLeod, M.K.L., David, A., McKee, A.S., Crawford, F., Kappler, J.W., and Marrack, P. (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. Journal of Immunology, 186 (5). pp. 2889-2896. (doi:10.4049/jimmunol.1002955)

MacLeod, M.K.L., McKee, A.S., David, A., Wang, J., Mason, R., Kappler, J.W., and Marrack, P. (2011) Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108 (19). pp. 7914-7919. (doi:10.1073/pnas.1104588108)

2010

MacLeod, M.K.L., Kappler, J.W., and Marrack, P. (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology, 130 (1). pp. 10-15. (doi:10.1111/j.1365-2567.2010.03260.x)

Marrack, P., Scott-Browne, J., and MacLeod, M.K.L. (2010) Terminating the immune response. Immunological Reviews, 236 (1). pp. 5-10. (doi:10.1111/j.1600-065X.2010.00928.x)

McKee, A.S., MacLeod, M.K.L., Kappler, J.W., and Marrack, P. (2010) Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biology, 8 (1). p. 37. (doi:10.1186/1741-7007-8-37)

Munks, M.W., McKee, A.S., MacLeod, M.K.L., Powell, R.L., Degen, J.L., Reisdorph, N.A., Kappler, J.W., and Marrack, P. (2010) Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood, 116 (24). pp. 5191-5199. (doi:10.1182/blood-2010-03-275529)

2009

MacLeod, M.K.L., Clambey, E.T., Kappler, J.W., and Marrack, P. (2009) CD4 memory T cells: What are they and what can they do? Seminars in Immunology, 21 (2). pp. 53-61. (doi:10.1016/j.smim.2009.02.006)

McKee, A.S., Munks, M.W., MacLeod, M.K.L., Fleenor, C.J., Van Rooijen, N., Kappler, J.W., and Marrack, P. (2009) Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. Journal of Immunology, 183 (7). pp. 4403-4414. (doi:10.4049/jimmunol.0900164)

2008

MacLeod, M.K.L., McKee, A., Crawford, F., White, J., Kappler, J., and Marrack, P. (2008) CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proceedings of the National Academy of Sciences of the United States of America, 105 (38). pp. 14521-14526. (doi:10.1073/pnas.0807449105)

McKee, A.S., MacLeod, M.K.L., White, J., Crawford, F., Kappler, J.W., and Marrack, P. (2008) Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. International Immunology, 20 (5). pp. 659-669. (doi:10.1093/intimm/dxn025)

Yang, B., Gay, D.L., MacLeod, M.K.L., Cao, X., Hala, T., Sweezer, E.M., Kappler, J., Marrack, P., and Oliver, P.M. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nature Immunology, 9 (12). pp. 1356-1363. (doi:10.1038/ni.1670)

2007

Mahajan, S., Cervera, A., MacLeod, M.K.L., Fillatreau, S., Perona-Wright, G., Meek, S., Smith, A., MacDonald, A., and Gray, D. (2007) The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. European Journal of Immunology, 37 (7). pp. 1796-1808. (doi:10.1002/eji.200636661)

2006

Crawford, A., Macleod, M., Schumacher, T., Corlett, L., and Gray, D. (2006) Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. Journal of Immunology, 176 (6). pp. 3498-3506.

Macleod, M.K.L., Kwakkenbos, M.J., Crawford, A., Brown, S., Stockinger, B., Schepers, K., Schumacher, T., and Gray, D. (2006) CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. Journal of Experimental Medicine, 203 (4). pp. 897-906. (doi:10.1084/jem.20050711)

Oliver, P.M. et al. (2006) Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity, 25 (6). pp. 929-940. (doi:10.1016/j.immuni.2006.10.012)

Robertson, J.M., Macleod, M.K.L., Marsden, V.S., Kappler, J.W., and Marrack, P. (2006) Not all CD4+ memory T cells are long lived. Immunological Reviews, 211 (1). pp. 58-66. (doi:10.1111/j.0105-2896.2006.00383.x)

2003

Adams, C.L., Macleod, M.K.L., Milner-White, E.J., Aitken, R., Garside, P., and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108 (3). pp. 274-287. (doi:10.1046/j.1365-2567.2003.01583.x)

2002

Lee, G.K., Park, H.J., Macleod, M., Chandler, P., Munn, D.H., and Mellor, A.L. (2002) Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology, 107 (4). pp. 452-460. (doi:10.1046/j.1365-2567.2002.01526.x)

This list was generated on Fri Jan 30 15:20:49 2015 GMT.
Number of items: 22.

Articles

Huang, Y. et al. (2013) Antigen-specific regulation of IgE antibodies by non-antigen-specific T cells. Journal of Immunology, 190 (3). pp. 913-921. (doi:10.4049/jimmunol.1202230)

Macleod, M.K.L., David, A., Jin, N., Noges, L., Wang, J., Kappler, J.W., and Marrack, P. (2013) Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence. PLoS ONE, 8 (4). e61775. (doi:10.1371/journal.pone.0061775)

Aviszus, K., Macleod, M., Kirchenbaum, G.A., Detanico, D.O., Heiser, R.A., St. Clair, J.B., Guo, W.J., and Wysocki, L.J. (2012) Antigen specific suppression of humoral immunity by anergic Ars/A1 B cells. Journal of Immunology, 189 (9). pp. 4275-4283.

MacLeod, M.K.L., David, A., McKee, A.S., Crawford, F., Kappler, J.W., and Marrack, P. (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. Journal of Immunology, 186 (5). pp. 2889-2896. (doi:10.4049/jimmunol.1002955)

MacLeod, M.K.L., McKee, A.S., David, A., Wang, J., Mason, R., Kappler, J.W., and Marrack, P. (2011) Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108 (19). pp. 7914-7919. (doi:10.1073/pnas.1104588108)

MacLeod, M.K.L., Kappler, J.W., and Marrack, P. (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology, 130 (1). pp. 10-15. (doi:10.1111/j.1365-2567.2010.03260.x)

Marrack, P., Scott-Browne, J., and MacLeod, M.K.L. (2010) Terminating the immune response. Immunological Reviews, 236 (1). pp. 5-10. (doi:10.1111/j.1600-065X.2010.00928.x)

McKee, A.S., MacLeod, M.K.L., Kappler, J.W., and Marrack, P. (2010) Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biology, 8 (1). p. 37. (doi:10.1186/1741-7007-8-37)

Munks, M.W., McKee, A.S., MacLeod, M.K.L., Powell, R.L., Degen, J.L., Reisdorph, N.A., Kappler, J.W., and Marrack, P. (2010) Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood, 116 (24). pp. 5191-5199. (doi:10.1182/blood-2010-03-275529)

MacLeod, M.K.L., Clambey, E.T., Kappler, J.W., and Marrack, P. (2009) CD4 memory T cells: What are they and what can they do? Seminars in Immunology, 21 (2). pp. 53-61. (doi:10.1016/j.smim.2009.02.006)

McKee, A.S., Munks, M.W., MacLeod, M.K.L., Fleenor, C.J., Van Rooijen, N., Kappler, J.W., and Marrack, P. (2009) Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. Journal of Immunology, 183 (7). pp. 4403-4414. (doi:10.4049/jimmunol.0900164)

MacLeod, M.K.L., McKee, A., Crawford, F., White, J., Kappler, J., and Marrack, P. (2008) CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proceedings of the National Academy of Sciences of the United States of America, 105 (38). pp. 14521-14526. (doi:10.1073/pnas.0807449105)

McKee, A.S., MacLeod, M.K.L., White, J., Crawford, F., Kappler, J.W., and Marrack, P. (2008) Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. International Immunology, 20 (5). pp. 659-669. (doi:10.1093/intimm/dxn025)

Yang, B., Gay, D.L., MacLeod, M.K.L., Cao, X., Hala, T., Sweezer, E.M., Kappler, J., Marrack, P., and Oliver, P.M. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nature Immunology, 9 (12). pp. 1356-1363. (doi:10.1038/ni.1670)

Mahajan, S., Cervera, A., MacLeod, M.K.L., Fillatreau, S., Perona-Wright, G., Meek, S., Smith, A., MacDonald, A., and Gray, D. (2007) The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. European Journal of Immunology, 37 (7). pp. 1796-1808. (doi:10.1002/eji.200636661)

Crawford, A., Macleod, M., Schumacher, T., Corlett, L., and Gray, D. (2006) Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. Journal of Immunology, 176 (6). pp. 3498-3506.

Macleod, M.K.L., Kwakkenbos, M.J., Crawford, A., Brown, S., Stockinger, B., Schepers, K., Schumacher, T., and Gray, D. (2006) CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. Journal of Experimental Medicine, 203 (4). pp. 897-906. (doi:10.1084/jem.20050711)

Oliver, P.M. et al. (2006) Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity, 25 (6). pp. 929-940. (doi:10.1016/j.immuni.2006.10.012)

Robertson, J.M., Macleod, M.K.L., Marsden, V.S., Kappler, J.W., and Marrack, P. (2006) Not all CD4+ memory T cells are long lived. Immunological Reviews, 211 (1). pp. 58-66. (doi:10.1111/j.0105-2896.2006.00383.x)

Adams, C.L., Macleod, M.K.L., Milner-White, E.J., Aitken, R., Garside, P., and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108 (3). pp. 274-287. (doi:10.1046/j.1365-2567.2003.01583.x)

Lee, G.K., Park, H.J., Macleod, M., Chandler, P., Munn, D.H., and Mellor, A.L. (2002) Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology, 107 (4). pp. 452-460. (doi:10.1046/j.1365-2567.2002.01526.x)

Book Sections

Bosio, C.M., Macleod, M., Marrack, P., and Kedl, R.M. (2012) Utility of mouse models in vaccine design and development. In: Morrow, W.J.W., Sheikh, N.A., Schmidt , C.S. and Davies, H. (eds.) Vaccinology: Principles and Practices. Wiley-Blackwell, Chichester, UK. ISBN 9781405185745

This list was generated on Fri Jan 30 15:20:49 2015 GMT.