Professor Sandosh Padmanabhan

  • Professor of Cardiovascular Genomics and Therapeutics (Institute of Cardiovascular and Medical Sciences)
  • Associate (School of Medicine)

telephone: 01413302228
email: Sandosh.Padmanabhan@glasgow.ac.uk

Research interests

Prof Sandosh Padmanabhan is Professor of Cardiovascular Genomics and Therapeutics at the University of Glasgow. He completed his MBBS and MD at JIPMER, Pondicherry, India and was awarded the Gold Medal for MD General Medicine by Pondicherry University in 1995. He moved to the UK as a junior doctor in 1996, and his PhD (1999-2003) on G-protein signalling in hypertension was awarded the Bellahouston Medal by the University of Glasgow in 2004. He received the Austin Doyle Award from the International Society of Hypertension in 2004. His pharmacogenetic genomewide linkage study led to a BHF Intermediate Fellowship (2006-2009). He was the lead on a genome wide association analysis of Hypertension between 2008 and 2010 resulting in the discovery of a new gene and pathway for hypertension. He was a visiting fellow to the Broad Institute of Harvard and MIT (2010-2012). He is one of the principal investigators of the MRC-NKRF DNA Bank for Glomerulonephritis. His current research includes genomics of hypertension and cardiovascular traits, pharmacogenomics and hypertension epidemiology. He is one of the lead of the Glasgow BP clinic and a co-director of the MSc (Clinical Pharmacology) course. He is a member of Generation Scotland executive, serves on the editorial board of Hypertension and Journal of Hypertension, the meetings committee of the British Pharmacologic Society, the research committee of the Wellcome Trust/Public Health Foundation of India and chairs the educational committee of British Hypertension Society. He is a Fellow of the Royal College of Physicians and a Fellow of the American Heart Association.

My Research:

Member:

 

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Serum Chloride - epidemiology and genetic dissection of a novel marker of cardiovascular risk
    British Heart Foundation
    2014 - 2017
     
  • Biomarker Discovery 2.0 - Rigorous and Robust Metabolite Characterization using Mass Spectrometry Fragmentation approaches (ISSF Fellowship)
    Wellcome Trust
    2014 - 2015
     
  • Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
    British Heart Foundation
    2013 - 2016
     
  • EU-MASCARA - Biomarkers for Cardiovascular Disease
    European Commission
    2011 - 2015
     
  • InterPregGen
    European Commission
    2011 - 2016
     
  • Genetic dissection of hypertension - SNPs, sequence, Pathways to clinical translation.
    British Heart Foundation
    2010 - 2011
     
  • Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
    British Heart Foundation
    2008 - 2011
     
  • Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
    British Heart Foundation
    2008 - 2011
     
  • High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
    British Heart Foundation
    2008 - 2009
     
  • Hypertension pharmacogenetics - discovering genetics determinants of blood pressure response
    British Heart Foundation
    2006 - 2009
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 1994
Number of items: 114.

2015

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi:10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)

Mccallum, L. et al. (2015) Longitudinal blood pressure control, long-term mortality and predictive utility of serum liver enzymes and bilirubin in hypertensive patients. Hypertension, 66(1), pp. 37-43. 25941342. (doi:10.1161/HYPERTENSIONAHA.114.04915) (PMID:PMC4461392)

Chittani, M. et al. (2015) TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. Journal of Hypertension, 33(6), pp. 1301-1309. (doi:10.1097/HJH.0000000000000541) (PMID:25695618)

Menni, C. et al. (2015) Metabolomic study of carotid–femoral pulse-wave velocity in women. Journal of Hypertension, 33(4), pp. 791-796. (doi:10.1097/HJH.0000000000000467) (PMID:25490711) (PMCID:PMC4354457)

McCallum, L., Lip, S., and Padmanabhan, S. (2015) The hidden hand of chloride in hypertension. Pflügers Archiv - European Journal of Physiology, 467(3), pp. 595-603. (doi:10.1007/s00424-015-1690-8) (PMID:25619794) (PMCID:PMC4325190)

Padmanabhan, S., Caulfield, M., and Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116(6), pp. 937-959. (doi:10.1161/CIRCRESAHA.116.303647) (PMID:25767282)

Wade, K. H. et al. (2015) Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. American Journal of Clinical Nutrition, 101(1), pp. 202-209. (doi:10.3945/ajcn.114.092981)

Wessel, J. et al. (2015) Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications, 6, 5897. (doi:10.1038/ncomms6897) (PMID:25631608) (PMCID:PMC4311266)

Fulton, R. L., Walters, M. R., Morton, R., Touyz, R. M., Dominiczak, A. F., Morrison, D. S., Padmanabhan, S., Meredith, P. A., McInnes, G. T., and Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65(5), 1008-U596. (doi:10.1161/HYPERTENSIONAHA.114.04945) (PMID:25801870)

Nuesch, E. et al. (2015) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, (doi:10.1093/ije/dyv074) (PMID:25979724) (Early Online Publication)

Patel, R., Jeemon, P., Stevens, K. K., Mccallum, L., Hastie, C. E., Schneider, A., Jardine, A. G., Mark, P. B., and Padmanabhan, S. (2015) Association between serumphosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. Journal of Hypertension, (doi:10.1097/HJH.0000000000000659) (Early Online Publication)

Quinn, T. J., Alghamdi, J., Padmanabhan, S., Porteous, D. J. , Smith, B. H., Hocking, L., Deary, I. J. , Gallacher, J., Messow, M., and Stott, D. J. (2015) Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age, (Accepted for Publication)

2014

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S., McCallum, L., Walters, M. R., Dominiczak, A. F., Touyz, R. M., and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5), pp. 1102-1107. (doi:10.1161/HYPERTENSIONAHA.114.03953) (PMID:25135183)

van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J., Donnan, P.T., Padmanabhan, S., Porteous, D.J., Hocking, L., and Smith, B.H. (2014) Does a history of depressionactuallymediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18(9), pp. 1223-1230. (doi:10.1002/j.1532-2149.2014.00470.x)

Arking, D. E. et al. (2014) Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics, 46(8), pp. 826-836. (doi:10.1038/ng.3014) (PMID:24952745) (PMCID:PMC4124521)

Yoneyama, S. et al. (2014) Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics, 23(9), pp. 2498-2510. (doi:10.1093/hmg/ddt626)

Marioni, R. E. et al. (2014) Molecular genetic contributions to socioeconomic status and intelligence. Intelligence, 44, pp. 26-32. (doi:10.1016/j.intell.2014.02.006)

Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), pp. 349-360. (doi:10.1016/j.ajhg.2013.12.016)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

Lange, L. A. et al. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with ldl cholesterol. American Journal of Human Genetics, 94(2), pp. 233-245. (doi:10.1016/j.ajhg.2014.01.010)

Graham, L., and Padmanabhan, S. (2014) NEDD4L in essential hypertension. Journal of Hypertension, 32(2), pp. 230-232. (doi:10.1097/HJH.0000000000000105)

Padmanabhan, S., (Ed.) (2014) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London. ISBN 9780123868831

Alghamdi, J., and Padmanabhan, S. (2014) Fundamentals of complex trait genetics and association studies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 235-257. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00012-8)

Alsanosi, S. M. M., Skiffington, C., and Padmanabhan, S. (2014) Pharmacokinetic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 341-364. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00017-7)

Brown, C., and Padmanabhan, S. (2014) QTc and sudden cardiac death. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 779-806. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00033-5)

Docherty, K. F., and Padmanabhan, S. (2014) Genomics and pharmacogenomics of lipid-lowering therapies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 715-746. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00031-1)

Gong, Y., McDonough, C. W., Padmanabhan, S., and Johnson, J. A. (2014) Hypertension pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 747-778. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00032-3)

Holmes, M. V. et al. (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349, g4164. (doi:10.1136/bmj.g4164)

Holmes, M. V. et al. (2014) Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal, 36(9), pp. 539-550. (doi:10.1093/eurheartj/eht571) (PMID:24474739) (PMCID:PMC4344957)

McCallum, L. et al. (2014) Response to effect of serum chloride on mortality in hypertensive patients. Hypertension, 63(3), e15-e15. (doi:10.1161/HYPERTENSIONAHA.113.02926)

McCallum, L., Lip, S., and Padmanabhan, S. (2014) Pharmacodynamic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 365-383. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00018-9)

Padmanabhan, S. (2014) Clinical trials in pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 309-320. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00015-3)

Padmanabhan, S. (2014) Pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 3-25. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00001-3)

Padmanabhan, S., Caulfield, M., and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, G., Grassi, G. and Redon, J. (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press : Boca Raton, FL, pp. 115-128. ISBN 9781841849973 (doi:10.1201/b17072-13)

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Taylor, A. E. et al. (2014) Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genetics, 10(12), e1004799. (doi:10.1371/journal.pgen.1004799)

Williamson, C. et al. (2014) Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients. European Heart Journal, 35(9), pp. 563-570. (doi:10.1093/eurheartj/eht539)

2013

Rosenthal, E. A., Ranchalis, J., Crosslin, D. R., Burt, A., Brunzell, J. D., Motulsky, A. G., Nickerson, D. A., Wijsman, E. M., Jarvik, G. P., and Padmanabhan, S. (2013) Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. American Journal of Human Genetics, 93(6), pp. 1035-1045. (doi:10.1016/j.ajhg.2013.10.019)

Menni, C., Mangino, M., Zhang, F., Clement, G., Snieder, H., Padmanabhan, S., and Spector, T.D. (2013) Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults. Journal of Hypertension, 31(12), pp. 2356-2361. (doi:10.1097/HJH.0b013e32836523c1)

McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62(5), pp. 836-843. (doi:10.1161/HYPERTENSIONAHA.113.01793)

Kalra, P.R., Morley, C., Barnes, S., Menown, I., Kassianos, G., Padmanabhan, S., Gupta, S., and Lang, C.C. (2013) Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study. International Journal of Cardiology, 167(6), pp. 2695-2699. (doi:10.1016/j.ijcard.2012.06.116)

Guo, D.-c. et al. (2013) Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. American Journal of Human Genetics, 93(2), pp. 398-404.

Johnsen, J. M. et al. (2013) Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI exome sequencing project. Blood, 122(4), pp. 590-597. (doi:10.1182/blood-2013-02-485094 )

Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62(1), pp. 190-196. (doi:10.1161/HYPERTENSIONAHA.111.00686)

Ganesh, S.K. et al. (2013) Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22(8), pp. 1663-1678. (doi:10.1093/hmg/dds555)

Norton, N. et al. (2013) Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circulation: Cardiovascular Genetics, 6(2), pp. 144-153. (doi:10.1161/CIRCGENETICS.111.000062)

Fu, W. et al. (2013) Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature, 493(7431), pp. 216-220. (doi:10.1038/nature11690)

Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., and Padmanabhan, S. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22(1), pp. 184-201. (doi:10.1093/hmg/dds396)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi:10.1161/HYPERTENSIONAHA.112.200741)

Dawson, J. et al. (2013) Acetaminophen use and change in blood pressure in a hypertensive population. Journal of Hypertension, 31(7), pp. 1485-1490. (doi:10.1097/HJH.0b013e328360f6f8)

Dawson, J. et al. (2013) Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension, 62(1), pp. 105-111. (doi:10.1161/HYPERTENSIONAHA.113.00859)

Hastie, C. et al. (2013) Long-term and ultra-long term blood pressure variability during follow–up and mortality in 14522 patients with hypertension. Hypertension, 62(4), pp. 698-705. (doi:10.1161/HYPERTENSIONAHA.113.01343)

McDonough, C.W., Gong, Y., Padmanabhan, S., Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F., Cooper-DeHoff, R.M., and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62(1), pp. 48-54. (doi:10.1161/HYPERTENSIONAHA.111.00823)

O'Connor, T. D., Kiezun, A., Bamshad, M., Rich, S. S., Smith, J. D., Turner, E., Leal, S. M., Akey, J. M., and Padmanabhan, S. (2013) Fine-scale patterns of population stratification confound rare variant association tests. PLoS ONE, 8(7), e65834. (doi:10.1371/journal.pone.0065834)

O'Seaghdha, C. M. et al. (2013) Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genetics, 9(9), e1003796. (doi:10.1371/journal.pgen.1003796)

Padmanabhan, S. (2013) Prospects for genetic risk prediction in hypertension. Hypertension, 61(5), pp. 961-963. (doi:10.1161/HYPERTENSIONAHA.113.00948)

Sridhar, G.R., Duggirala, R., and Padmanabhan, S. (2013) Emerging face of genetics, genomics and diabetes. International Journal of Diabetes in Developing Countries, 33(4), pp. 183-185. (doi:10.1007/s13410-013-0164-9)

Turner, S.T. et al. (2013) Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension, 62, pp. 391-397. (doi:10.1161/HYPERTENSIONAHA.111.00436)

Wang, G. et al. (2013) Genomics of elite sporting performance: what little we know and necessary advances. In: Friedmann, T., Dunlap, J. C. and Goodwin, S. F. (eds.) Advances in Genetics. Academic Press: Amsterdam, pp. 123-49. ISBN 9780124077034

den Hoed, M. et al. (2013) Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45(6), pp. 621-631. (doi:10.1038/ng.2610)

2012

van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492(7429), pp. 369-375. (doi:10.1038/nature11677) (PMID:23222517) (PMCID:PMC3623669)

Sanna-Cherchi, S. et al. (2012) Copy-number disorders are a common cause of congenital kidney malformations. American Journal of Human Genetics, 91(6), pp. 987-997. (doi:10.1016/j.ajhg.2012.10.007)

Paul, L. et al. (2012) Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults. Hypertension, 60(3), pp. 631-638. (doi:10.1161/HYPERTENSIONAHA.112.191510)

Boileau, C. et al. (2012) TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nature Genetics, 44(8), pp. 916-921. (doi:10.1038/ng.2348)

Emond, M. J. et al. (2012) Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic pseudomonas aeruginosa infection in cystic fibrosis. Nature Genetics, 44(8), pp. 886-889. (doi:10.1038/ng.2344)

Lyons, P.A. et al. (2012) Genetically distinct subsets within ANCA-associated vasculitis. New England Journal of Medicine, 367(3), pp. 214-223. (doi:10.1056/NEJMoa1108735)

Saxena, R. et al. (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90(3), pp. 410-425. (doi:10.1016/j.ajhg.2011.12.022)

Delles, C., and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28(3), pp. 296-304. (doi:10.1016/j.cjca.2012.02.004)

Jeemon, P. et al. (2012) Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population. Indian Journal of Medical Research, 135(4), pp. 485-493.

Padmanabhan, S., Newton-Cheh, C., and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28(8), pp. 397-408. (doi:10.1016/j.tig.2012.04.001)

Padmanabhan, S., and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, A. E. and Mancia, G. (eds.) Special Issues in Hypertension. Springer Milan: Milan, pp. 439-452. ISBN 9788847026001 (doi:10.1007/978-88-470-2601-8_33)

Salvi, E. et al. (2012) Genomewide Association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension, 59(2), pp. 248-255. (doi:10.1161/HYPERTENSIONAHA.111.181990)

2011

Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89(6), pp. 688-700. (doi:10.1016/j.ajhg.2011.10.013)

Freathy, R.M. et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40(6), pp. 1617-28. (doi:10.1093/ije/dyr077)

Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88(1), pp. 6-18. (doi:10.1016/j.ajhg.2010.11.007 )

Grassi, G. et al. (2011) Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population. Journal of Hypertension, 29(6), pp. 1121-1127777777777. (doi:10.1097/HJH.0b013e328346d72c)

Menni, C. et al. (2011) Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study. Psychosomatic Medicine, 73(4), pp. 304-309. (doi:10.1097/PSY.0b013e318212e0be)

Shah, S. et al. (2011) Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4(6), pp. 626-635. (doi:10.1161/CIRCGENETICS.111.960203)

Stanescu, H.C. et al. (2011) Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. New England Journal of Medicine, 364(7), pp. 616-626. (doi:10.1056/NEJMoa1009742)

2010

Timpson, N.J. et al. (2010) Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. American Journal of Clinical Nutrition, 92(2), pp. 375-382. (doi:10.3945/ajcn.2010.29438)

Paul, L., Hastie, C. E., Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F., McInnes, G. T., and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55(2), pp. 567-574. (doi:10.1161/HYPERTENSIONAHA.109.144808)

Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Feehally, J. et al. (2010) HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis. Journal of the American Society of Nephrology, 21(10), pp. 1791-1797. (doi:10.1681/ASN.2010010076)

Hastie, C. et al. (2010) Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. European Heart Journal, 31(2), pp. 222-226. (doi:10.1093/eurheartj/ehp317)

Hastie, C. E., Padmanabhan, S., and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010(509581), (doi:10.4061/2010/509581)

Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C., and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212(1), pp. 1-8. (doi:10.1016/j.atherosclerosis.2010.01.029)

Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28(10), pp. 2007-2009. (doi:10.1097/HJH.0b013e32833f2f56)

Padmanabhan, S., Hastie, C., Prabhakaran, D., and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132(5), pp. 567-78.

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi:10.1097/HJH.0b013e32833594d7)

Sotoodehnia, N. et al. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42(12), pp. 1068-1076. (doi:10.1038/ng.716)

2009

Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85(5), pp. 628-642. (doi:10.1016/j.ajhg.2009.10.014)

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M., and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94(11), pp. 4324-4333. (doi:10.1210/jc.2009-1406)

Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi:10.1142/S1793351X09000665)

Dominiczak, A. F., Delles, C., and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940.

Padmanabhan, S. (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27(8), pp. 1521-1523.

Padmanabhan, S., Menni, C., Prabhakaran, D., and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97(3), pp. 385-391.

Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L., and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27(4), pp. 730-735. (doi:10.1097/HJH.0b013e328324ed58)

2008

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi:10.1016/j.tem.2008.07.010 )

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7), pp. 1343-1352. (doi:10.1097/HJH.0b013e3282fe1d67)

Padmanabhan, S., Melander, O., Hastie, C., Menni, C., Delles, C., Connell, J. M., and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi:10.1097/HJH.0b013e3282ff634f)

Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A., and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26, S113-S113.

Hastie, C., Padmanabhan, S., Slack, R., Isles, C., and Pell, J. (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22(10), pp. 717-718.

Padmanabhan, S., Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G., and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26, S18-S18.

2007

Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S., Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E., and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116(17), pp. 1915-1924. (doi:10.1161/CIRCULATIONAHA.107.710293)

2006

Padmanabhan, S. et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47(3), pp. 603-608. (doi:10.1161/01.HYP.0000197947.62601.9d)

2005

Whiteley, L., Padmanabhan, S., Hole, D., and Isles, C. (2005) Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care, 28(7), pp. 1588-1593.

2004

Charchar, F., Padmanabhan, S., Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A., Connell, J.M., Watt, G.C.M., Dominiczak, A.F., and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22(S1), S58-S59.

Padmanabhan, S., Connell, J.M.C., Dominiczak, A.F., Inglis, G., Macfarlane, P.W., and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22(S1), S180-S181.

2003

Swan, L., Birnie, D., Padmanabhan, S., Inglis, G., Connell, J., and Hillis, W. (2003) The genetic determination of left ventricular mass in healthy adults. European Heart Journal, 24, 579-U9. (doi:10.1016/S0195-668X(02)00524-9)

Tomaszewski, M., Charchar, F.J., Padmanabhan, S., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17(6), pp. 379-380. (doi:10.1038/sj.jhh.1001559)

2002

Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39(2), pp. 353-356. (doi:10.1161/hy0202.103413 )

Stanton, T., Inglis, G.C., Padmanabhan, S., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15(5), pp. 512-518.

1994

Dutta, T. K., Padmanabhan, S., Hamide, A., and Ramesh, J. (1994) Localised tetanus mimicking incomplete transverse myelitis. Lancet, 343(8903), pp. 983-984. (doi:10.1016/S0140-6736(94)90111-2)

This list was generated on Fri Sep 4 15:04:39 2015 BST.
Number of items: 114.

Articles

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi:10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)

Mccallum, L. et al. (2015) Longitudinal blood pressure control, long-term mortality and predictive utility of serum liver enzymes and bilirubin in hypertensive patients. Hypertension, 66(1), pp. 37-43. 25941342. (doi:10.1161/HYPERTENSIONAHA.114.04915) (PMID:PMC4461392)

Chittani, M. et al. (2015) TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. Journal of Hypertension, 33(6), pp. 1301-1309. (doi:10.1097/HJH.0000000000000541) (PMID:25695618)

Menni, C. et al. (2015) Metabolomic study of carotid–femoral pulse-wave velocity in women. Journal of Hypertension, 33(4), pp. 791-796. (doi:10.1097/HJH.0000000000000467) (PMID:25490711) (PMCID:PMC4354457)

McCallum, L., Lip, S., and Padmanabhan, S. (2015) The hidden hand of chloride in hypertension. Pflügers Archiv - European Journal of Physiology, 467(3), pp. 595-603. (doi:10.1007/s00424-015-1690-8) (PMID:25619794) (PMCID:PMC4325190)

Padmanabhan, S., Caulfield, M., and Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116(6), pp. 937-959. (doi:10.1161/CIRCRESAHA.116.303647) (PMID:25767282)

Wade, K. H. et al. (2015) Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. American Journal of Clinical Nutrition, 101(1), pp. 202-209. (doi:10.3945/ajcn.114.092981)

Wessel, J. et al. (2015) Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications, 6, 5897. (doi:10.1038/ncomms6897) (PMID:25631608) (PMCID:PMC4311266)

Fulton, R. L., Walters, M. R., Morton, R., Touyz, R. M., Dominiczak, A. F., Morrison, D. S., Padmanabhan, S., Meredith, P. A., McInnes, G. T., and Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65(5), 1008-U596. (doi:10.1161/HYPERTENSIONAHA.114.04945) (PMID:25801870)

Nuesch, E. et al. (2015) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, (doi:10.1093/ije/dyv074) (PMID:25979724) (Early Online Publication)

Patel, R., Jeemon, P., Stevens, K. K., Mccallum, L., Hastie, C. E., Schneider, A., Jardine, A. G., Mark, P. B., and Padmanabhan, S. (2015) Association between serumphosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. Journal of Hypertension, (doi:10.1097/HJH.0000000000000659) (Early Online Publication)

Quinn, T. J., Alghamdi, J., Padmanabhan, S., Porteous, D. J. , Smith, B. H., Hocking, L., Deary, I. J. , Gallacher, J., Messow, M., and Stott, D. J. (2015) Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age, (Accepted for Publication)

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S., McCallum, L., Walters, M. R., Dominiczak, A. F., Touyz, R. M., and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5), pp. 1102-1107. (doi:10.1161/HYPERTENSIONAHA.114.03953) (PMID:25135183)

van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J., Donnan, P.T., Padmanabhan, S., Porteous, D.J., Hocking, L., and Smith, B.H. (2014) Does a history of depressionactuallymediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18(9), pp. 1223-1230. (doi:10.1002/j.1532-2149.2014.00470.x)

Arking, D. E. et al. (2014) Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics, 46(8), pp. 826-836. (doi:10.1038/ng.3014) (PMID:24952745) (PMCID:PMC4124521)

Yoneyama, S. et al. (2014) Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics, 23(9), pp. 2498-2510. (doi:10.1093/hmg/ddt626)

Marioni, R. E. et al. (2014) Molecular genetic contributions to socioeconomic status and intelligence. Intelligence, 44, pp. 26-32. (doi:10.1016/j.intell.2014.02.006)

Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), pp. 349-360. (doi:10.1016/j.ajhg.2013.12.016)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

Lange, L. A. et al. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with ldl cholesterol. American Journal of Human Genetics, 94(2), pp. 233-245. (doi:10.1016/j.ajhg.2014.01.010)

Graham, L., and Padmanabhan, S. (2014) NEDD4L in essential hypertension. Journal of Hypertension, 32(2), pp. 230-232. (doi:10.1097/HJH.0000000000000105)

Holmes, M. V. et al. (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349, g4164. (doi:10.1136/bmj.g4164)

Holmes, M. V. et al. (2014) Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal, 36(9), pp. 539-550. (doi:10.1093/eurheartj/eht571) (PMID:24474739) (PMCID:PMC4344957)

McCallum, L. et al. (2014) Response to effect of serum chloride on mortality in hypertensive patients. Hypertension, 63(3), e15-e15. (doi:10.1161/HYPERTENSIONAHA.113.02926)

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Taylor, A. E. et al. (2014) Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genetics, 10(12), e1004799. (doi:10.1371/journal.pgen.1004799)

Williamson, C. et al. (2014) Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients. European Heart Journal, 35(9), pp. 563-570. (doi:10.1093/eurheartj/eht539)

Rosenthal, E. A., Ranchalis, J., Crosslin, D. R., Burt, A., Brunzell, J. D., Motulsky, A. G., Nickerson, D. A., Wijsman, E. M., Jarvik, G. P., and Padmanabhan, S. (2013) Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. American Journal of Human Genetics, 93(6), pp. 1035-1045. (doi:10.1016/j.ajhg.2013.10.019)

Menni, C., Mangino, M., Zhang, F., Clement, G., Snieder, H., Padmanabhan, S., and Spector, T.D. (2013) Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults. Journal of Hypertension, 31(12), pp. 2356-2361. (doi:10.1097/HJH.0b013e32836523c1)

McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62(5), pp. 836-843. (doi:10.1161/HYPERTENSIONAHA.113.01793)

Kalra, P.R., Morley, C., Barnes, S., Menown, I., Kassianos, G., Padmanabhan, S., Gupta, S., and Lang, C.C. (2013) Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study. International Journal of Cardiology, 167(6), pp. 2695-2699. (doi:10.1016/j.ijcard.2012.06.116)

Guo, D.-c. et al. (2013) Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. American Journal of Human Genetics, 93(2), pp. 398-404.

Johnsen, J. M. et al. (2013) Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI exome sequencing project. Blood, 122(4), pp. 590-597. (doi:10.1182/blood-2013-02-485094 )

Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62(1), pp. 190-196. (doi:10.1161/HYPERTENSIONAHA.111.00686)

Ganesh, S.K. et al. (2013) Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22(8), pp. 1663-1678. (doi:10.1093/hmg/dds555)

Norton, N. et al. (2013) Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circulation: Cardiovascular Genetics, 6(2), pp. 144-153. (doi:10.1161/CIRCGENETICS.111.000062)

Fu, W. et al. (2013) Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature, 493(7431), pp. 216-220. (doi:10.1038/nature11690)

Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., and Padmanabhan, S. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22(1), pp. 184-201. (doi:10.1093/hmg/dds396)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi:10.1161/HYPERTENSIONAHA.112.200741)

Dawson, J. et al. (2013) Acetaminophen use and change in blood pressure in a hypertensive population. Journal of Hypertension, 31(7), pp. 1485-1490. (doi:10.1097/HJH.0b013e328360f6f8)

Dawson, J. et al. (2013) Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension, 62(1), pp. 105-111. (doi:10.1161/HYPERTENSIONAHA.113.00859)

Hastie, C. et al. (2013) Long-term and ultra-long term blood pressure variability during follow–up and mortality in 14522 patients with hypertension. Hypertension, 62(4), pp. 698-705. (doi:10.1161/HYPERTENSIONAHA.113.01343)

McDonough, C.W., Gong, Y., Padmanabhan, S., Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F., Cooper-DeHoff, R.M., and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62(1), pp. 48-54. (doi:10.1161/HYPERTENSIONAHA.111.00823)

O'Connor, T. D., Kiezun, A., Bamshad, M., Rich, S. S., Smith, J. D., Turner, E., Leal, S. M., Akey, J. M., and Padmanabhan, S. (2013) Fine-scale patterns of population stratification confound rare variant association tests. PLoS ONE, 8(7), e65834. (doi:10.1371/journal.pone.0065834)

O'Seaghdha, C. M. et al. (2013) Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genetics, 9(9), e1003796. (doi:10.1371/journal.pgen.1003796)

Padmanabhan, S. (2013) Prospects for genetic risk prediction in hypertension. Hypertension, 61(5), pp. 961-963. (doi:10.1161/HYPERTENSIONAHA.113.00948)

Sridhar, G.R., Duggirala, R., and Padmanabhan, S. (2013) Emerging face of genetics, genomics and diabetes. International Journal of Diabetes in Developing Countries, 33(4), pp. 183-185. (doi:10.1007/s13410-013-0164-9)

Turner, S.T. et al. (2013) Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension, 62, pp. 391-397. (doi:10.1161/HYPERTENSIONAHA.111.00436)

den Hoed, M. et al. (2013) Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45(6), pp. 621-631. (doi:10.1038/ng.2610)

van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492(7429), pp. 369-375. (doi:10.1038/nature11677) (PMID:23222517) (PMCID:PMC3623669)

Sanna-Cherchi, S. et al. (2012) Copy-number disorders are a common cause of congenital kidney malformations. American Journal of Human Genetics, 91(6), pp. 987-997. (doi:10.1016/j.ajhg.2012.10.007)

Paul, L. et al. (2012) Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults. Hypertension, 60(3), pp. 631-638. (doi:10.1161/HYPERTENSIONAHA.112.191510)

Boileau, C. et al. (2012) TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nature Genetics, 44(8), pp. 916-921. (doi:10.1038/ng.2348)

Emond, M. J. et al. (2012) Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic pseudomonas aeruginosa infection in cystic fibrosis. Nature Genetics, 44(8), pp. 886-889. (doi:10.1038/ng.2344)

Lyons, P.A. et al. (2012) Genetically distinct subsets within ANCA-associated vasculitis. New England Journal of Medicine, 367(3), pp. 214-223. (doi:10.1056/NEJMoa1108735)

Saxena, R. et al. (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90(3), pp. 410-425. (doi:10.1016/j.ajhg.2011.12.022)

Delles, C., and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28(3), pp. 296-304. (doi:10.1016/j.cjca.2012.02.004)

Jeemon, P. et al. (2012) Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population. Indian Journal of Medical Research, 135(4), pp. 485-493.

Padmanabhan, S., Newton-Cheh, C., and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28(8), pp. 397-408. (doi:10.1016/j.tig.2012.04.001)

Salvi, E. et al. (2012) Genomewide Association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension, 59(2), pp. 248-255. (doi:10.1161/HYPERTENSIONAHA.111.181990)

Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89(6), pp. 688-700. (doi:10.1016/j.ajhg.2011.10.013)

Freathy, R.M. et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40(6), pp. 1617-28. (doi:10.1093/ije/dyr077)

Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88(1), pp. 6-18. (doi:10.1016/j.ajhg.2010.11.007 )

Grassi, G. et al. (2011) Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population. Journal of Hypertension, 29(6), pp. 1121-1127777777777. (doi:10.1097/HJH.0b013e328346d72c)

Menni, C. et al. (2011) Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study. Psychosomatic Medicine, 73(4), pp. 304-309. (doi:10.1097/PSY.0b013e318212e0be)

Shah, S. et al. (2011) Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4(6), pp. 626-635. (doi:10.1161/CIRCGENETICS.111.960203)

Stanescu, H.C. et al. (2011) Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. New England Journal of Medicine, 364(7), pp. 616-626. (doi:10.1056/NEJMoa1009742)

Timpson, N.J. et al. (2010) Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. American Journal of Clinical Nutrition, 92(2), pp. 375-382. (doi:10.3945/ajcn.2010.29438)

Paul, L., Hastie, C. E., Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F., McInnes, G. T., and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55(2), pp. 567-574. (doi:10.1161/HYPERTENSIONAHA.109.144808)

Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Feehally, J. et al. (2010) HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis. Journal of the American Society of Nephrology, 21(10), pp. 1791-1797. (doi:10.1681/ASN.2010010076)

Hastie, C. et al. (2010) Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. European Heart Journal, 31(2), pp. 222-226. (doi:10.1093/eurheartj/ehp317)

Hastie, C. E., Padmanabhan, S., and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010(509581), (doi:10.4061/2010/509581)

Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C., and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212(1), pp. 1-8. (doi:10.1016/j.atherosclerosis.2010.01.029)

Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28(10), pp. 2007-2009. (doi:10.1097/HJH.0b013e32833f2f56)

Padmanabhan, S., Hastie, C., Prabhakaran, D., and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132(5), pp. 567-78.

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi:10.1097/HJH.0b013e32833594d7)

Sotoodehnia, N. et al. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42(12), pp. 1068-1076. (doi:10.1038/ng.716)

Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85(5), pp. 628-642. (doi:10.1016/j.ajhg.2009.10.014)

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M., and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94(11), pp. 4324-4333. (doi:10.1210/jc.2009-1406)

Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi:10.1142/S1793351X09000665)

Dominiczak, A. F., Delles, C., and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940.

Padmanabhan, S. (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27(8), pp. 1521-1523.

Padmanabhan, S., Menni, C., Prabhakaran, D., and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97(3), pp. 385-391.

Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L., and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27(4), pp. 730-735. (doi:10.1097/HJH.0b013e328324ed58)

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi:10.1016/j.tem.2008.07.010 )

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7), pp. 1343-1352. (doi:10.1097/HJH.0b013e3282fe1d67)

Padmanabhan, S., Melander, O., Hastie, C., Menni, C., Delles, C., Connell, J. M., and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi:10.1097/HJH.0b013e3282ff634f)

Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A., and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26, S113-S113.

Hastie, C., Padmanabhan, S., Slack, R., Isles, C., and Pell, J. (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22(10), pp. 717-718.

Padmanabhan, S., Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G., and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26, S18-S18.

Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S., Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E., and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116(17), pp. 1915-1924. (doi:10.1161/CIRCULATIONAHA.107.710293)

Padmanabhan, S. et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47(3), pp. 603-608. (doi:10.1161/01.HYP.0000197947.62601.9d)

Whiteley, L., Padmanabhan, S., Hole, D., and Isles, C. (2005) Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care, 28(7), pp. 1588-1593.

Charchar, F., Padmanabhan, S., Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A., Connell, J.M., Watt, G.C.M., Dominiczak, A.F., and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22(S1), S58-S59.

Padmanabhan, S., Connell, J.M.C., Dominiczak, A.F., Inglis, G., Macfarlane, P.W., and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22(S1), S180-S181.

Swan, L., Birnie, D., Padmanabhan, S., Inglis, G., Connell, J., and Hillis, W. (2003) The genetic determination of left ventricular mass in healthy adults. European Heart Journal, 24, 579-U9. (doi:10.1016/S0195-668X(02)00524-9)

Tomaszewski, M., Charchar, F.J., Padmanabhan, S., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17(6), pp. 379-380. (doi:10.1038/sj.jhh.1001559)

Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39(2), pp. 353-356. (doi:10.1161/hy0202.103413 )

Stanton, T., Inglis, G.C., Padmanabhan, S., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15(5), pp. 512-518.

Dutta, T. K., Padmanabhan, S., Hamide, A., and Ramesh, J. (1994) Localised tetanus mimicking incomplete transverse myelitis. Lancet, 343(8903), pp. 983-984. (doi:10.1016/S0140-6736(94)90111-2)

Book Sections

Alghamdi, J., and Padmanabhan, S. (2014) Fundamentals of complex trait genetics and association studies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 235-257. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00012-8)

Alsanosi, S. M. M., Skiffington, C., and Padmanabhan, S. (2014) Pharmacokinetic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 341-364. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00017-7)

Brown, C., and Padmanabhan, S. (2014) QTc and sudden cardiac death. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 779-806. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00033-5)

Docherty, K. F., and Padmanabhan, S. (2014) Genomics and pharmacogenomics of lipid-lowering therapies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 715-746. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00031-1)

Gong, Y., McDonough, C. W., Padmanabhan, S., and Johnson, J. A. (2014) Hypertension pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 747-778. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00032-3)

McCallum, L., Lip, S., and Padmanabhan, S. (2014) Pharmacodynamic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 365-383. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00018-9)

Padmanabhan, S. (2014) Clinical trials in pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 309-320. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00015-3)

Padmanabhan, S. (2014) Pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 3-25. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00001-3)

Padmanabhan, S., Caulfield, M., and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, G., Grassi, G. and Redon, J. (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press : Boca Raton, FL, pp. 115-128. ISBN 9781841849973 (doi:10.1201/b17072-13)

Wang, G. et al. (2013) Genomics of elite sporting performance: what little we know and necessary advances. In: Friedmann, T., Dunlap, J. C. and Goodwin, S. F. (eds.) Advances in Genetics. Academic Press: Amsterdam, pp. 123-49. ISBN 9780124077034

Padmanabhan, S., and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, A. E. and Mancia, G. (eds.) Special Issues in Hypertension. Springer Milan: Milan, pp. 439-452. ISBN 9788847026001 (doi:10.1007/978-88-470-2601-8_33)

Edited Books

Padmanabhan, S., (Ed.) (2014) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London. ISBN 9780123868831

This list was generated on Fri Sep 4 15:04:39 2015 BST.