Dr Sandosh Padmanabhan

- Reader (Institute of Cardiovascular and Medical Sciences)
telephone: 01413302228
email: Sandosh.Padmanabhan@glasgow.ac.uk
Sandosh Padmanabhan is working on a British Heart Foundation Intermediate Fellowship (Hypertension pharmacogenetics - Discovering genetic determinants of blood pressure response). He is one of the principal investigators in the MRC/Kidney Research Glomerulonephritis DNA Bank part of the MRC DNA banking initiative. His main research interests include cardiovascular genetic epidemiology, genetic analysis of complex traits and pharmacogenetics. He coordinates the Pharmacogenomics and Molecular Medicine course of the MSc Clinical Pharmacology programme at the University of Glasgow, and his major clinical commitment includes running the Glasgow Blood Pressure Clinic.
My Research:
Member:
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2012
van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492 (7429). pp. 369-375. ISSN 0028-0836 (doi:10.1038/nature11677)
Sanna-Cherchi, S. et al. (2012) Copy-number disorders are a common cause of congenital kidney malformations. American Journal of Human Genetics, 91 (6). pp. 987-997. ISSN 0002-9297 (doi:10.1016/j.ajhg.2012.10.007)
Lyons, P.A. et al. (2012) Genetically distinct subsets within ANCA-associated vasculitis. New England Journal of Medicine, 367 (3). pp. 214-223. ISSN 0028-4793 (doi:10.1056/NEJMoa1108735)
Saxena, R. et al. (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90 (3). pp. 410-425. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.12.022)
Delles, C., and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28 (3). pp. 296-304. ISSN 0828-282X (doi:10.1016/j.cjca.2012.02.004)
Jeemon, P. et al. (2012) Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population. Indian Journal of Medical Research, 135 (4). pp. 485-493. ISSN 0971-5916
Padmanabhan, S., Newton-Cheh, C., and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28 (8). pp. 397-408. ISSN 0168-9525 (doi:10.1016/j.tig.2012.04.001)
Salvi, E. et al. (2012) Genomewide Association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension, 59 (2). pp. 248-255. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.181990)
2011
Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89 (6). pp. 688-700. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.10.013)
Freathy, R.M. et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40 (6). pp. 1617-28. ISSN 0300-5771
Lanktree, Matthew B et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88 (1). pp. 6-18. ISSN 0002-9297 (doi:10.1016/j.ajhg.2010.11.007 )
Grassi, G. et al. (2011) Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population. Journal of Hypertension, 29 (6). pp. 1121-1127777777777. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328346d72c)
Menni, C. et al. (2011) Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study. Psychosomatic Medicine, 73 (4). pp. 304-309. ISSN 0033-3174 (doi:10.1097/PSY.0b013e318212e0be)
Shah, S. et al. (2011) Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4 (6). pp. 626-635. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.111.960203)
Stanescu, H.C. et al. (2011) Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. New England Journal of Medicine, 364 (7). pp. 616-626. ISSN 0028-4793 (doi:10.1056/NEJMoa1009742)
2010
Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 (12). pp. 1299-1308. ISSN 0925-4439 (doi:10.1016/j.bbadis.2009.12.006)
Feehally, J. et al. (2010) HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis. Journal of the American Society of Nephrology, 21 (10). pp. 1791-1797. ISSN 1046-6673 (doi:10.1681/ASN.2010010076)
Hastie, C. et al. (2010) Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. European Heart Journal, 31 (2). pp. 222-226. ISSN 0195-668X (doi:10.1093/eurheartj/ehp317)
Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C., and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212 (1). pp. 1-8. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2010.01.029)
Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28 (10). pp. 2007-2009. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833f2f56)
Padmanabhan, S., Hastie, C., Prabhakaran, D., and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132 (5). pp. 567-78. ISSN 0971-5916
Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6 (10). e1001177. ISSN 1553-7390 (doi:10.1371/journal.pgen.1001177)
Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28 (3). pp. 465-477. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833594d7)
Paul, L., Hastie, C.E., Li, W., Harrow, C., Muir, S., Connell, J.M.C., Dominiczak, A.F., McInnes, G.T., and Padmanabhan, S. (2010) Resting Heart Rate Pattern During Follow-Up and Mortality in Hypertensive Patients. Hypertension, 55 (2). pp. 567-574. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.109.144808)
Sotoodehnia, N. et al. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42 (12). pp. 1068-1076. ISSN 1061-4036 (doi:10.1038/ng.716)
Timpson, N. J. et al. (2010) Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. American Journal of Clinical Nutrition, 92 (2). pp. 375-382. ISSN 0002-9165 (doi:10.3945/ajcn.2010.29438)
2009
Talmud, PJ et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85 (5). pp. 628-642. ISSN 0002-9297 (doi:10.1016/j.ajhg.2009.10.014)
Alvarez-Madrazo, S. et al. (2009) Familial and Phenotypic Associations of the Aldosterone Renin Ratio. Journal of Clinical Endocrinology and Metabolism, 94 (11). pp. 4324-4333. ISSN 0021-972X
Dominiczak, A. F., Delles, C, and Padmanabhan, S (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27 (5). pp. 939-940.
Padmanabhan, S (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27 (8). pp. 1521-1523.
Padmanabhan, S, Menni, C, Prabhakaran, D, and Dominiczak, AF (2009) Discovering the genetic determinants of complex diseases. Current Science, 97 (3). pp. 385-391.
Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L., and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27 (4). pp. 730-735. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328324ed58)
2008
Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19 (9). pp. 309-316. ISSN 1043-2760 (doi:10.1016/j.tem.2008.07.010 )
Delles, C et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26 (7). pp. 1343-1352. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282fe1d67)
Hastie, C, Padmanabhan, S, Slack, R, Dominiczak, AF, and Pell, J (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26 . S113-S113. ISSN 0263-6352
Hastie, C, Padmanabhan, S, Slack, R, Isles, C, and Pell, J (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22 (10). pp. 717-718. ISSN 0950-9240
Padmanabhan, S, Melander, O, Hastie, C, Menni, C, Delles, C, Connell, J, and Dominiczak, AF (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26 (7). pp. 1275-1281.
Padmanabhan, S, Menni, C, Lee, WK, Brambilla, P, Laing, S, Sega, R, Cesana, G, Mancia, G, and Dominiczak, AF (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26 . S18-S18.
2007
Tomaszewski, M, Charchar, FJ, Lynch, MD, Padmanabhan, S, Wang, WY, Miller, WH, Grzeszczak, W, Maric, C, Zukowska-Szczechowska, E, and Dominiczak, AF (2007) Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation, 116 (17). pp. 1915-1924.
Tomaszewski, M, Charchar, FJ, Lynch, MD, Padmanabhan, S, Wang, WYS, Miller, WH, Grzeszczak, W, Maric, C, Zukowska-Szczechowska, E, and Dominiczak, AF (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116 . pp. 1915-1924. (doi:10.1161/CIRCULATIONAHA.107.710293)
2006
Padmanabhan, S et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47 . pp. 603-608. (doi:10.1161/01.HYP.0000197947.62601.9d)
2005
Whiteley, L., Padmanabhan, S., Hole, D., and Isles, C. (2005) Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care, 28 (7). pp. 1588-1593. ISSN 0149-5992
Hole, D, Isles, C, Padmanabhan, S, and Whiteley, L (2005) Should diabetes be considered a coronary heart disease risk equivalent? Results from 25 years of follow-up in the Renfrew and Paisley Survey. Diabetes Care, 28 . pp. 1588-1593.
2004
Charchar, F., Padmanabhan, S., Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A., Connell, J.M., Watt, G.C.M., Dominiczak, A.F., and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension - Supplement, 22 (S1). S58-S59. ISSN 0952-1178
Padmanabhan, S., Connell, J.M.C., Dominiczak, A.F., Inglis, G., Macfarlane, P.W., and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension - Supplement, 22 (S1). S180-S181. ISSN 0952-1178
2003
Charchar, FJ, Dominiczak, A.F., Grzeszczak, W, Padmanabhan, S, Tomaszewski, M, and Zukowska-Szczechowska, E (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17 (6). pp. 379-380.
Swan, L, Birnie, DH, Padmanabhan, S, Inglis, G, Connell, JMC, and Hillis, WS (2003) The genetic determination of left ventricular mass in healthy adults. European Heart Journal, 24 . 579-U9. (doi:10.1016/S0195-668X(02)00524-9)
2002
Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39 . pp. 353-356. ISSN 0194-911X
Stanton, T., Inglis, G.C., Padmanabhan, S., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15 (5). pp. 512-518.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
British Heart Foundation
2013 - 2016
- InterPregGen
European Commission
2011 - 2016
- Genetic dissection of hypertension - SNPs, sequence, Pathways to clinical translation.
British Heart Foundation
2010 - 2011
- Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
British Heart Foundation
2008 - 2011
- Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
British Heart Foundation
2008 - 2011
- High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
British Heart Foundation
2008 - 2009
- Hypertension pharmacogenetics - discovering genetics determinants of blood pressure response
British Heart Foundation
2006 - 2009
