Professor Sandosh Padmanabhan

  • Professor of Cardiovascular Genomics and Therapeutics (Institute of Cardiovascular and Medical Sciences)

telephone: 01413302228
email: Sandosh.Padmanabhan@glasgow.ac.uk

Research interests

Prof Sandosh Padmanabhan is Professor of Cardiovascular Genomics and Therapeutics at the University of Glasgow. He completed his MBBS and MD at JIPMER, Pondicherry, India and was awarded the Gold Medal for MD General Medicine by Pondicherry University in 1995. He moved to the UK as a junior doctor in 1996, and his PhD (1999-2003) on G-protein signalling in hypertension was awarded the Bellahouston Medal by the University of Glasgow in 2004. He received the Austin Doyle Award from the International Society of Hypertension in 2004. His pharmacogenetic genomewide linkage study led to a BHF Intermediate Fellowship (2006-2009). He was the lead on a genome wide association analysis of Hypertension between 2008 and 2010 resulting in the discovery of a new gene and pathway for hypertension. He was a visiting fellow to the Broad Institute of Harvard and MIT (2010-2012). He is one of the principal investigators of the MRC-NKRF DNA Bank for Glomerulonephritis. His current research includes genomics of hypertension and cardiovascular traits, pharmacogenomics and hypertension epidemiology. He is one of the lead of the Glasgow BP clinic and a co-director of the MSc (Clinical Pharmacology) course. He is a member of Generation Scotland executive, serves on the editorial board of Hypertension and Journal of Hypertension, the meetings committee of the British Pharmacologic Society, the research committee of the Wellcome Trust/Public Health Foundation of India and chairs the educational committee of British Hypertension Society. He is a Fellow of the Royal College of Physicians and a Fellow of the American Heart Association.

My Research:

Member:

 

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Serum Chloride - epidemiology and genetic dissection of a novel marker of cardiovascular risk
    British Heart Foundation
    2014 - 2017
     
  • Biomarker Discovery 2.0 - Rigorous and Robust Metabolite Characterization using Mass Spectrometry Fragmentation approaches (ISSF Fellowship)
    Wellcome Trust
    2014 - 2015
     
  • Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
    British Heart Foundation
    2013 - 2016
     
  • EU-MASCARA - Biomarkers for Cardiovascular Disease
    European Commission
    2011 - 2015
     
  • InterPregGen
    European Commission
    2011 - 2016
     
  • Genetic dissection of hypertension - SNPs, sequence, Pathways to clinical translation.
    British Heart Foundation
    2010 - 2011
     
  • Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
    British Heart Foundation
    2008 - 2011
     
  • Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
    British Heart Foundation
    2008 - 2011
     
  • High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
    British Heart Foundation
    2008 - 2009
     
  • Hypertension pharmacogenetics - discovering genetics determinants of blood pressure response
    British Heart Foundation
    2006 - 2009
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 1994
Number of items: 104.

2015

Wade, K.H. et al. (2015) Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. American Journal of Clinical Nutrition . ISSN 0002-9165 (doi:10.3945/ajcn.114.092981) (Early Online Publication)

2014

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S., McCallum, L., Walters, M. R., Dominiczak, A. F., Touyz, R. M., and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64 (5). pp. 1102-1107. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.114.03953)

van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J., Donnan, P.T., Padmanabhan, S., Porteous, D.J., Hocking, L., and Smith, B.H. (2014) Does a history of depressionactuallymediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18 (9). pp. 1223-1230. ISSN 1090-3801 (doi:10.1002/j.1532-2149.2014.00470.x)

Arking, D. E. et al. (2014) Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics, 46 (8). pp. 826-836. ISSN 1061-4036 (doi:10.1038/ng.3014)

Marioni, R. E. et al. (2014) Molecular genetic contributions to socioeconomic status and intelligence. Intelligence, 44 . pp. 26-32. ISSN 0160-2896 (doi:10.1016/j.intell.2014.02.006)

Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94 (3). pp. 349-360. ISSN 0002-9297 (doi:10.1016/j.ajhg.2013.12.016)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63 (3). pp. 551-558. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01423)

Lange, L. A. et al. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with ldl cholesterol. American Journal of Human Genetics, 94 (2). pp. 233-245. ISSN 0002-9297 (doi:10.1016/j.ajhg.2014.01.010)

Graham, L., and Padmanabhan, S. (2014) NEDD4L in essential hypertension. Journal of Hypertension, 32 (2). pp. 230-232. ISSN 0263-6352 (doi:10.1097/HJH.0000000000000105)

Padmanabhan, S., (Ed.) (2014) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London. ISBN 9780123868831

Alghamdi, J., and Padmanabhan, S. (2014) Fundamentals of complex trait genetics and association studies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 235-257. ISBN 9780123868831

Alsanosi, S. M. M., Skiffington, C., and Padmanabhan, S. (2014) Pharmacokinetic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 341-364. ISBN 9780123868831

Brown, C., and Padmanabhan, S. (2014) QTc and sudden cardiac death. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 779-806. ISBN 9780123868831

Docherty, K. F., and Padmanabhan, S. (2014) Genomics and pharmacogenomics of lipid-lowering therapies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 715-746. ISBN 9780123868831

Gong, Y., McDonough, C. W., Padmanabhan, S., and Johnson, J. A. (2014) Hypertension pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 747-778. ISBN 9780123868831

Holmes, M. V. et al. (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349 . g4164. ISSN 1756-1833 (doi:10.1136/bmj.g4164)

Holmes, M. V. et al. (2014) Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal . ISSN 0195-668X (doi:10.1093/eurheartj/eht571)

McCallum, L. et al. (2014) Response to effect of serum chloride on mortality in hypertensive patients. Hypertension, 63 (3). e15-e15. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.02926)

McCallum, L., Lip, S., and Padmanabhan, S. (2014) Pharmacodynamic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 365-383. ISBN 9780123868831

Padmanabhan, S. (2014) Clinical trials in pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 309-320. ISBN 9780123868831

Padmanabhan, S. (2014) Pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 3-25. ISBN 9780123868831

Padmanabhan, S., Caulfield, M., and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, G., Grassi, G. and Redon, J. (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press , Boca Raton, FL, pp. 115-128. ISBN 9781841849973

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64 (5). pp. 918-923. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.114.03132)

Williamson, C. et al. (2014) Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients. European Heart Journal, 35 (9). pp. 563-570. ISSN 0195-668X (doi:10.1093/eurheartj/eht539)

Yoneyama, S. et al. (2014) Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics, 23 (9). pp. 2498-2510. ISSN 0964-6906 (doi:10.1093/hmg/ddt626)

2013

Rosenthal, E. A., Ranchalis, J., Crosslin, D. R., Burt, A., Brunzell, J. D., Motulsky, A. G., Nickerson, D. A., Wijsman, E. M., Jarvik, G. P., and Padmanabhan, S. (2013) Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. American Journal of Human Genetics, 93 (6). pp. 1035-1045. ISSN 0002-9297 (doi:10.1016/j.ajhg.2013.10.019)

Menni, C., Mangino, M., Zhang, F., Clement, G., Snieder, H., Padmanabhan, S., and Spector, T.D. (2013) Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults. Journal of Hypertension, 31 (12). pp. 2356-2361. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32836523c1)

McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62 (5). pp. 836-843. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01793)

Hastie, C., Sloan, W., Dominiczak, A., Morrison, D., and Padmanabhan, S. (2013) Long-term and ultra long-term blood pressure variability during follow-up and mortality in 14 522 patients with hypertension. Hypertension, 62 (4). pp. 698-705. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01343)

Kalra, P.R., Morley, C., Barnes, S., Menown, I., Kassianos, G., Padmanabhan, S., Gupta, S., and Lang, C.C. (2013) Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study. International Journal of Cardiology, 167 (6). pp. 2695-2699. ISSN 0167-5273 (doi:10.1016/j.ijcard.2012.06.116)

Guo, D.-c. et al. (2013) Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. American Journal of Human Genetics, 93 (2). pp. 398-404. ISSN 0002-9297

Johnsen, J. M. et al. (2013) Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI exome sequencing project. Blood, 122 (4). pp. 590-597. ISSN 0006-4971 (doi:10.1182/blood-2013-02-485094 )

Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62 (1). pp. 190-196. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00686)

Ganesh, S.K. et al. (2013) Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22 (8). pp. 1663-1678. ISSN 0964-6906 (doi:10.1093/hmg/dds555)

Norton, N. et al. (2013) Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circulation: Cardiovascular Genetics, 6 (2). pp. 144-153. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.111.000062)

Fu, W. et al. (2013) Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature, 493 (7431). pp. 216-220. ISSN 0028-0836 (doi:10.1038/nature11690)

Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., and Padmanabhan, S. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22 (1). pp. 184-201. ISSN 0964-6906 (doi:10.1093/hmg/dds396)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61 (1). pp. 232-239. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.112.200741)

Dawson, J. et al. (2013) Acetaminophen use and change in blood pressure in a hypertensive population. Journal of Hypertension, 31 (7). pp. 1485-1490. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328360f6f8)

Dawson, J. et al. (2013) Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension, 62 (1). pp. 105-111. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.00859)

Hastie, C. et al. (2013) Long-term and ultra-long term blood pressure variability during follow–up and mortality in 14522 patients with hypertension. Hypertension, 62 (4). pp. 698-705. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01343)

McDonough, C.W., Gong, Y., Padmanabhan, S., Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F., Cooper-DeHoff, R.M., and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62 (1). pp. 48-54. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00823)

O'Connor, T. D., Kiezun, A., Bamshad, M., Rich, S. S., Smith, J. D., Turner, E., Leal, S. M., Akey, J. M., and Padmanabhan, S. (2013) Fine-scale patterns of population stratification confound rare variant association tests. PLoS ONE, 8 (7). e65834. ISSN 1932-6203 (doi:10.1371/journal.pone.0065834)

O'Seaghdha, C. M. et al. (2013) Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genetics, 9 (9). e1003796. ISSN 1553-7390 (doi:10.1371/journal.pgen.1003796)

Padmanabhan, S. (2013) Prospects for genetic risk prediction in hypertension. Hypertension, 61 (5). pp. 961-963. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.00948)

Sridhar, G.R., Duggirala, R., and Padmanabhan, S. (2013) Emerging face of genetics, genomics and diabetes. International Journal of Diabetes in Developing Countries, 33 (4). pp. 183-185. ISSN 0973-3930 (doi:10.1007/s13410-013-0164-9)

Turner, S.T. et al. (2013) Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension, 62 . pp. 391-397. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00436)

Wang, G. et al. (2013) Genomics of elite sporting performance: what little we know and necessary advances. In: Friedmann, T., Dunlap, J. C. and Goodwin, S. F. (eds.) Advances in Genetics. Academic Press, Amsterdam, pp. 123-49. ISBN 9780124077034

den Hoed, M. et al. (2013) Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6). pp. 621-631. ISSN 1061-4036 (doi:10.1038/ng.2610)

2012

van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492 (7429). pp. 369-375. ISSN 0028-0836 (doi:10.1038/nature11677)

Sanna-Cherchi, S. et al. (2012) Copy-number disorders are a common cause of congenital kidney malformations. American Journal of Human Genetics, 91 (6). pp. 987-997. ISSN 0002-9297 (doi:10.1016/j.ajhg.2012.10.007)

Paul, L. et al. (2012) Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults. Hypertension, 60 (3). pp. 631-638. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.112.191510)

Boileau, C. et al. (2012) TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nature Genetics, 44 (8). pp. 916-921. ISSN 1061-4036 (doi:10.1038/ng.2348)

Emond, M. J. et al. (2012) Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic pseudomonas aeruginosa infection in cystic fibrosis. Nature Genetics, 44 (8). pp. 886-889. ISSN 1061-4036 (doi:10.1038/ng.2344)

Lyons, P.A. et al. (2012) Genetically distinct subsets within ANCA-associated vasculitis. New England Journal of Medicine, 367 (3). pp. 214-223. ISSN 0028-4793 (doi:10.1056/NEJMoa1108735)

Saxena, R. et al. (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90 (3). pp. 410-425. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.12.022)

Delles, C., and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28 (3). pp. 296-304. ISSN 0828-282X (doi:10.1016/j.cjca.2012.02.004)

Jeemon, P. et al. (2012) Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population. Indian Journal of Medical Research, 135 (4). pp. 485-493. ISSN 0971-5916

Padmanabhan, S., Newton-Cheh, C., and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28 (8). pp. 397-408. ISSN 0168-9525 (doi:10.1016/j.tig.2012.04.001)

Padmanabhan, S., and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, A. E. and Mancia, G. (eds.) Special Issues in Hypertension. Springer Milan, Milan, pp. 439-452. ISBN 9788847026001

Salvi, E. et al. (2012) Genomewide Association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension, 59 (2). pp. 248-255. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.181990)

2011

Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89 (6). pp. 688-700. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.10.013)

Freathy, R.M. et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40 (6). pp. 1617-28. ISSN 0300-5771 (doi:10.1093/ije/dyr077)

Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88 (1). pp. 6-18. ISSN 0002-9297 (doi:10.1016/j.ajhg.2010.11.007 )

Grassi, G. et al. (2011) Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population. Journal of Hypertension, 29 (6). pp. 1121-1127777777777. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328346d72c)

Menni, C. et al. (2011) Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study. Psychosomatic Medicine, 73 (4). pp. 304-309. ISSN 0033-3174 (doi:10.1097/PSY.0b013e318212e0be)

Shah, S. et al. (2011) Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4 (6). pp. 626-635. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.111.960203)

Stanescu, H.C. et al. (2011) Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. New England Journal of Medicine, 364 (7). pp. 616-626. ISSN 0028-4793 (doi:10.1056/NEJMoa1009742)

2010

Timpson, N.J. et al. (2010) Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. American Journal of Clinical Nutrition, 92 (2). pp. 375-382. ISSN 0002-9165 (doi:10.3945/ajcn.2010.29438)

Paul, L., Hastie, C. E., Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F., McInnes, G. T., and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55 (2). pp. 567-574. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.109.144808)

Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802 (12). pp. 1299-1308. ISSN 0925-4439 (doi:10.1016/j.bbadis.2009.12.006)

Feehally, J. et al. (2010) HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis. Journal of the American Society of Nephrology, 21 (10). pp. 1791-1797. ISSN 1046-6673 (doi:10.1681/ASN.2010010076)

Hastie, C. et al. (2010) Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. European Heart Journal, 31 (2). pp. 222-226. ISSN 0195-668X (doi:10.1093/eurheartj/ehp317)

Hastie, C. E., Padmanabhan, S., and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010 (509581). ISSN 2090-0384 (doi:10.4061/2010/509581)

Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C., and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212 (1). pp. 1-8. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2010.01.029)

Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28 (10). pp. 2007-2009. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833f2f56)

Padmanabhan, S., Hastie, C., Prabhakaran, D., and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132 (5). pp. 567-78. ISSN 0971-5916

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6 (10). e1001177. ISSN 1553-7390 (doi:10.1371/journal.pgen.1001177)

Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28 (3). pp. 465-477. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833594d7)

Sotoodehnia, N. et al. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42 (12). pp. 1068-1076. ISSN 1061-4036 (doi:10.1038/ng.716)

2009

Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85 (5). pp. 628-642. ISSN 0002-9297 (doi:10.1016/j.ajhg.2009.10.014)

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M., and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94 (11). pp. 4324-4333. ISSN 0021-972X (doi:10.1210/jc.2009-1406)

Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3 (1). pp. 77-90. ISSN 1793-351X (doi:10.1142/S1793351X09000665)

Dominiczak, A. F., Delles, C., and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27 (5). pp. 939-940.

Padmanabhan, S. (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27 (8). pp. 1521-1523.

Padmanabhan, S., Menni, C., Prabhakaran, D., and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97 (3). pp. 385-391.

Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L., and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27 (4). pp. 730-735. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328324ed58)

2008

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19 (9). pp. 309-316. ISSN 1043-2760 (doi:10.1016/j.tem.2008.07.010 )

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26 (7). pp. 1343-1352. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282fe1d67)

Padmanabhan, S., Melander, O., Hastie, C., Menni, C., Delles, C., Connell, J. M., and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26 (7). pp. 1275-1281. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282ff634f)

Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A., and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26 . S113-S113. ISSN 0263-6352

Hastie, C., Padmanabhan, S., Slack, R., Isles, C., and Pell, J. (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22 (10). pp. 717-718. ISSN 0950-9240

Padmanabhan, S., Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G., and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26 . S18-S18.

2007

Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S., Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E., and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation, 116 (17). pp. 1915-1924.

Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S., Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E., and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116 . pp. 1915-1924. (doi:10.1161/CIRCULATIONAHA.107.710293)

2006

Padmanabhan, S. et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47 . pp. 603-608. (doi:10.1161/01.HYP.0000197947.62601.9d)

2005

Whiteley, L., Padmanabhan, S., Hole, D., and Isles, C. (2005) Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care, 28 (7). pp. 1588-1593. ISSN 0149-5992

2004

Charchar, F., Padmanabhan, S., Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A., Connell, J.M., Watt, G.C.M., Dominiczak, A.F., and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22 (S1). S58-S59. ISSN 0952-1178

Padmanabhan, S., Connell, J.M.C., Dominiczak, A.F., Inglis, G., Macfarlane, P.W., and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22 (S1). S180-S181. ISSN 0952-1178

2003

Swan, L., Birnie, D., Padmanabhan, S., Inglis, G., Connell, J., and Hillis, W. (2003) The genetic determination of left ventricular mass in healthy adults. European Heart Journal, 24 . 579-U9. (doi:10.1016/S0195-668X(02)00524-9)

Tomaszewski, M., Charchar, F.J., Padmanabhan, S., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17 (6). pp. 379-380. ISSN 0950-9240 (doi:10.1038/sj.jhh.1001559)

2002

Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39 . pp. 353-356. ISSN 0194-911X

Stanton, T., Inglis, G.C., Padmanabhan, S., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15 (5). pp. 512-518.

1994

Dutta, T. K., Padmanabhan, S., Hamide, A., and Ramesh, J. (1994) Localised tetanus mimicking incomplete transverse myelitis. Lancet, 343 (8903). pp. 983-984. ISSN 0140-6736 (doi:10.1016/S0140-6736(94)90111-2)

This list was generated on Fri Dec 19 15:52:40 2014 GMT.
Number of items: 104.

Article

Wade, K.H. et al. (2015) Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. American Journal of Clinical Nutrition . ISSN 0002-9165 (doi:10.3945/ajcn.114.092981) (Early Online Publication)

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S., McCallum, L., Walters, M. R., Dominiczak, A. F., Touyz, R. M., and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64 (5). pp. 1102-1107. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.114.03953)

van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J., Donnan, P.T., Padmanabhan, S., Porteous, D.J., Hocking, L., and Smith, B.H. (2014) Does a history of depressionactuallymediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18 (9). pp. 1223-1230. ISSN 1090-3801 (doi:10.1002/j.1532-2149.2014.00470.x)

Arking, D. E. et al. (2014) Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics, 46 (8). pp. 826-836. ISSN 1061-4036 (doi:10.1038/ng.3014)

Marioni, R. E. et al. (2014) Molecular genetic contributions to socioeconomic status and intelligence. Intelligence, 44 . pp. 26-32. ISSN 0160-2896 (doi:10.1016/j.intell.2014.02.006)

Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94 (3). pp. 349-360. ISSN 0002-9297 (doi:10.1016/j.ajhg.2013.12.016)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63 (3). pp. 551-558. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01423)

Lange, L. A. et al. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with ldl cholesterol. American Journal of Human Genetics, 94 (2). pp. 233-245. ISSN 0002-9297 (doi:10.1016/j.ajhg.2014.01.010)

Graham, L., and Padmanabhan, S. (2014) NEDD4L in essential hypertension. Journal of Hypertension, 32 (2). pp. 230-232. ISSN 0263-6352 (doi:10.1097/HJH.0000000000000105)

Holmes, M. V. et al. (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349 . g4164. ISSN 1756-1833 (doi:10.1136/bmj.g4164)

Holmes, M. V. et al. (2014) Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal . ISSN 0195-668X (doi:10.1093/eurheartj/eht571)

McCallum, L. et al. (2014) Response to effect of serum chloride on mortality in hypertensive patients. Hypertension, 63 (3). e15-e15. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.02926)

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64 (5). pp. 918-923. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.114.03132)

Williamson, C. et al. (2014) Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients. European Heart Journal, 35 (9). pp. 563-570. ISSN 0195-668X (doi:10.1093/eurheartj/eht539)

Yoneyama, S. et al. (2014) Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics, 23 (9). pp. 2498-2510. ISSN 0964-6906 (doi:10.1093/hmg/ddt626)

Rosenthal, E. A., Ranchalis, J., Crosslin, D. R., Burt, A., Brunzell, J. D., Motulsky, A. G., Nickerson, D. A., Wijsman, E. M., Jarvik, G. P., and Padmanabhan, S. (2013) Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. American Journal of Human Genetics, 93 (6). pp. 1035-1045. ISSN 0002-9297 (doi:10.1016/j.ajhg.2013.10.019)

Menni, C., Mangino, M., Zhang, F., Clement, G., Snieder, H., Padmanabhan, S., and Spector, T.D. (2013) Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults. Journal of Hypertension, 31 (12). pp. 2356-2361. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32836523c1)

McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62 (5). pp. 836-843. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01793)

Hastie, C., Sloan, W., Dominiczak, A., Morrison, D., and Padmanabhan, S. (2013) Long-term and ultra long-term blood pressure variability during follow-up and mortality in 14 522 patients with hypertension. Hypertension, 62 (4). pp. 698-705. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01343)

Kalra, P.R., Morley, C., Barnes, S., Menown, I., Kassianos, G., Padmanabhan, S., Gupta, S., and Lang, C.C. (2013) Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study. International Journal of Cardiology, 167 (6). pp. 2695-2699. ISSN 0167-5273 (doi:10.1016/j.ijcard.2012.06.116)

Guo, D.-c. et al. (2013) Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. American Journal of Human Genetics, 93 (2). pp. 398-404. ISSN 0002-9297

Johnsen, J. M. et al. (2013) Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI exome sequencing project. Blood, 122 (4). pp. 590-597. ISSN 0006-4971 (doi:10.1182/blood-2013-02-485094 )

Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62 (1). pp. 190-196. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00686)

Ganesh, S.K. et al. (2013) Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22 (8). pp. 1663-1678. ISSN 0964-6906 (doi:10.1093/hmg/dds555)

Norton, N. et al. (2013) Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circulation: Cardiovascular Genetics, 6 (2). pp. 144-153. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.111.000062)

Fu, W. et al. (2013) Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature, 493 (7431). pp. 216-220. ISSN 0028-0836 (doi:10.1038/nature11690)

Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., and Padmanabhan, S. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22 (1). pp. 184-201. ISSN 0964-6906 (doi:10.1093/hmg/dds396)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61 (1). pp. 232-239. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.112.200741)

Dawson, J. et al. (2013) Acetaminophen use and change in blood pressure in a hypertensive population. Journal of Hypertension, 31 (7). pp. 1485-1490. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328360f6f8)

Dawson, J. et al. (2013) Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension, 62 (1). pp. 105-111. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.00859)

Hastie, C. et al. (2013) Long-term and ultra-long term blood pressure variability during follow–up and mortality in 14522 patients with hypertension. Hypertension, 62 (4). pp. 698-705. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01343)

McDonough, C.W., Gong, Y., Padmanabhan, S., Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F., Cooper-DeHoff, R.M., and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62 (1). pp. 48-54. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00823)

O'Connor, T. D., Kiezun, A., Bamshad, M., Rich, S. S., Smith, J. D., Turner, E., Leal, S. M., Akey, J. M., and Padmanabhan, S. (2013) Fine-scale patterns of population stratification confound rare variant association tests. PLoS ONE, 8 (7). e65834. ISSN 1932-6203 (doi:10.1371/journal.pone.0065834)

O'Seaghdha, C. M. et al. (2013) Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genetics, 9 (9). e1003796. ISSN 1553-7390 (doi:10.1371/journal.pgen.1003796)

Padmanabhan, S. (2013) Prospects for genetic risk prediction in hypertension. Hypertension, 61 (5). pp. 961-963. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.00948)

Sridhar, G.R., Duggirala, R., and Padmanabhan, S. (2013) Emerging face of genetics, genomics and diabetes. International Journal of Diabetes in Developing Countries, 33 (4). pp. 183-185. ISSN 0973-3930 (doi:10.1007/s13410-013-0164-9)

Turner, S.T. et al. (2013) Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension, 62 . pp. 391-397. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00436)

den Hoed, M. et al. (2013) Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6). pp. 621-631. ISSN 1061-4036 (doi:10.1038/ng.2610)

van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492 (7429). pp. 369-375. ISSN 0028-0836 (doi:10.1038/nature11677)

Sanna-Cherchi, S. et al. (2012) Copy-number disorders are a common cause of congenital kidney malformations. American Journal of Human Genetics, 91 (6). pp. 987-997. ISSN 0002-9297 (doi:10.1016/j.ajhg.2012.10.007)

Paul, L. et al. (2012) Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults. Hypertension, 60 (3). pp. 631-638. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.112.191510)

Boileau, C. et al. (2012) TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nature Genetics, 44 (8). pp. 916-921. ISSN 1061-4036 (doi:10.1038/ng.2348)

Emond, M. J. et al. (2012) Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic pseudomonas aeruginosa infection in cystic fibrosis. Nature Genetics, 44 (8). pp. 886-889. ISSN 1061-4036 (doi:10.1038/ng.2344)

Lyons, P.A. et al. (2012) Genetically distinct subsets within ANCA-associated vasculitis. New England Journal of Medicine, 367 (3). pp. 214-223. ISSN 0028-4793 (doi:10.1056/NEJMoa1108735)

Saxena, R. et al. (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90 (3). pp. 410-425. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.12.022)

Delles, C., and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28 (3). pp. 296-304. ISSN 0828-282X (doi:10.1016/j.cjca.2012.02.004)

Jeemon, P. et al. (2012) Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population. Indian Journal of Medical Research, 135 (4). pp. 485-493. ISSN 0971-5916

Padmanabhan, S., Newton-Cheh, C., and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28 (8). pp. 397-408. ISSN 0168-9525 (doi:10.1016/j.tig.2012.04.001)

Salvi, E. et al. (2012) Genomewide Association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension, 59 (2). pp. 248-255. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.181990)

Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89 (6). pp. 688-700. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.10.013)

Freathy, R.M. et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40 (6). pp. 1617-28. ISSN 0300-5771 (doi:10.1093/ije/dyr077)

Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88 (1). pp. 6-18. ISSN 0002-9297 (doi:10.1016/j.ajhg.2010.11.007 )

Grassi, G. et al. (2011) Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population. Journal of Hypertension, 29 (6). pp. 1121-1127777777777. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328346d72c)

Menni, C. et al. (2011) Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study. Psychosomatic Medicine, 73 (4). pp. 304-309. ISSN 0033-3174 (doi:10.1097/PSY.0b013e318212e0be)

Shah, S. et al. (2011) Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4 (6). pp. 626-635. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.111.960203)

Stanescu, H.C. et al. (2011) Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. New England Journal of Medicine, 364 (7). pp. 616-626. ISSN 0028-4793 (doi:10.1056/NEJMoa1009742)

Timpson, N.J. et al. (2010) Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. American Journal of Clinical Nutrition, 92 (2). pp. 375-382. ISSN 0002-9165 (doi:10.3945/ajcn.2010.29438)

Paul, L., Hastie, C. E., Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F., McInnes, G. T., and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55 (2). pp. 567-574. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.109.144808)

Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802 (12). pp. 1299-1308. ISSN 0925-4439 (doi:10.1016/j.bbadis.2009.12.006)

Feehally, J. et al. (2010) HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis. Journal of the American Society of Nephrology, 21 (10). pp. 1791-1797. ISSN 1046-6673 (doi:10.1681/ASN.2010010076)

Hastie, C. et al. (2010) Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. European Heart Journal, 31 (2). pp. 222-226. ISSN 0195-668X (doi:10.1093/eurheartj/ehp317)

Hastie, C. E., Padmanabhan, S., and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010 (509581). ISSN 2090-0384 (doi:10.4061/2010/509581)

Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C., and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212 (1). pp. 1-8. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2010.01.029)

Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28 (10). pp. 2007-2009. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833f2f56)

Padmanabhan, S., Hastie, C., Prabhakaran, D., and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132 (5). pp. 567-78. ISSN 0971-5916

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6 (10). e1001177. ISSN 1553-7390 (doi:10.1371/journal.pgen.1001177)

Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28 (3). pp. 465-477. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833594d7)

Sotoodehnia, N. et al. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42 (12). pp. 1068-1076. ISSN 1061-4036 (doi:10.1038/ng.716)

Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85 (5). pp. 628-642. ISSN 0002-9297 (doi:10.1016/j.ajhg.2009.10.014)

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M., and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94 (11). pp. 4324-4333. ISSN 0021-972X (doi:10.1210/jc.2009-1406)

Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3 (1). pp. 77-90. ISSN 1793-351X (doi:10.1142/S1793351X09000665)

Dominiczak, A. F., Delles, C., and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27 (5). pp. 939-940.

Padmanabhan, S. (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27 (8). pp. 1521-1523.

Padmanabhan, S., Menni, C., Prabhakaran, D., and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97 (3). pp. 385-391.

Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L., and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27 (4). pp. 730-735. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328324ed58)

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19 (9). pp. 309-316. ISSN 1043-2760 (doi:10.1016/j.tem.2008.07.010 )

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26 (7). pp. 1343-1352. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282fe1d67)

Padmanabhan, S., Melander, O., Hastie, C., Menni, C., Delles, C., Connell, J. M., and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26 (7). pp. 1275-1281. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282ff634f)

Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A., and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26 . S113-S113. ISSN 0263-6352

Hastie, C., Padmanabhan, S., Slack, R., Isles, C., and Pell, J. (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22 (10). pp. 717-718. ISSN 0950-9240

Padmanabhan, S., Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G., and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26 . S18-S18.

Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S., Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E., and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation, 116 (17). pp. 1915-1924.

Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S., Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E., and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116 . pp. 1915-1924. (doi:10.1161/CIRCULATIONAHA.107.710293)

Padmanabhan, S. et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47 . pp. 603-608. (doi:10.1161/01.HYP.0000197947.62601.9d)

Whiteley, L., Padmanabhan, S., Hole, D., and Isles, C. (2005) Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care, 28 (7). pp. 1588-1593. ISSN 0149-5992

Charchar, F., Padmanabhan, S., Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A., Connell, J.M., Watt, G.C.M., Dominiczak, A.F., and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22 (S1). S58-S59. ISSN 0952-1178

Padmanabhan, S., Connell, J.M.C., Dominiczak, A.F., Inglis, G., Macfarlane, P.W., and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22 (S1). S180-S181. ISSN 0952-1178

Swan, L., Birnie, D., Padmanabhan, S., Inglis, G., Connell, J., and Hillis, W. (2003) The genetic determination of left ventricular mass in healthy adults. European Heart Journal, 24 . 579-U9. (doi:10.1016/S0195-668X(02)00524-9)

Tomaszewski, M., Charchar, F.J., Padmanabhan, S., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17 (6). pp. 379-380. ISSN 0950-9240 (doi:10.1038/sj.jhh.1001559)

Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39 . pp. 353-356. ISSN 0194-911X

Stanton, T., Inglis, G.C., Padmanabhan, S., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15 (5). pp. 512-518.

Dutta, T. K., Padmanabhan, S., Hamide, A., and Ramesh, J. (1994) Localised tetanus mimicking incomplete transverse myelitis. Lancet, 343 (8903). pp. 983-984. ISSN 0140-6736 (doi:10.1016/S0140-6736(94)90111-2)

Book Section

Alghamdi, J., and Padmanabhan, S. (2014) Fundamentals of complex trait genetics and association studies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 235-257. ISBN 9780123868831

Alsanosi, S. M. M., Skiffington, C., and Padmanabhan, S. (2014) Pharmacokinetic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 341-364. ISBN 9780123868831

Brown, C., and Padmanabhan, S. (2014) QTc and sudden cardiac death. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 779-806. ISBN 9780123868831

Docherty, K. F., and Padmanabhan, S. (2014) Genomics and pharmacogenomics of lipid-lowering therapies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 715-746. ISBN 9780123868831

Gong, Y., McDonough, C. W., Padmanabhan, S., and Johnson, J. A. (2014) Hypertension pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 747-778. ISBN 9780123868831

McCallum, L., Lip, S., and Padmanabhan, S. (2014) Pharmacodynamic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 365-383. ISBN 9780123868831

Padmanabhan, S. (2014) Clinical trials in pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 309-320. ISBN 9780123868831

Padmanabhan, S. (2014) Pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London, pp. 3-25. ISBN 9780123868831

Padmanabhan, S., Caulfield, M., and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, G., Grassi, G. and Redon, J. (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press , Boca Raton, FL, pp. 115-128. ISBN 9781841849973

Wang, G. et al. (2013) Genomics of elite sporting performance: what little we know and necessary advances. In: Friedmann, T., Dunlap, J. C. and Goodwin, S. F. (eds.) Advances in Genetics. Academic Press, Amsterdam, pp. 123-49. ISBN 9780124077034

Padmanabhan, S., and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, A. E. and Mancia, G. (eds.) Special Issues in Hypertension. Springer Milan, Milan, pp. 439-452. ISBN 9788847026001

Edited Book

Padmanabhan, S., (Ed.) (2014) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, London. ISBN 9780123868831

This list was generated on Fri Dec 19 15:52:40 2014 GMT.