- Lecturer (Institute of Cardiovascular and Medical Sciences)
As a recently appointed lecturer on the BBSRC Integrative Mammalian Biology (IMB) initiative the central theme of my research is to allow the translation of knowledge gained from single molecules back to the whole organism, including in vivo studies. To date, my research has focused on therapeutic intervention for cardiovascular disease using both pharmacological agents and gene delivery protocols. A central feature in both these disciplines is the relative lack of targeting capacity for either agent towards a specific disease site. Therefore, integral to my research interests is the identification of novel targeting ligands identified using phage display which may subsequently be used to direct both gene- and pharmacology-based interventions. In the case of gene-based therapy, I have focused on viral vectors to deliver reporter genes to localise gene expression following genetic alteration of the virus capsid to allow de- and re-targeting. Additionally, the combination of pharmacological and gene-based therapies may provide further benefit than the use of each approach alone for a number of diseases affecting the cardiovascular system and stroke.