- Professor of Cardiology (Institute of Cardiovascular and Medical Sciences)
Institute of C&MS
Glasgow G12 8TA
Professor John McMurray leads an extensive programme of research into heart failure which includes studies of pathophysiological mechanisms and drug action, population based outcome studies and clinical trials. Current CSO and BHF funded projects include investigation of the pathophysiological basis of anaemia in heart failure (with Sattar and Jardine), identification of the mechanism of action of the vasodilator hydralazine in human blood vessels (with Delles and Dominiczak), evaluation of the incremental prognostic value microvolt T wave alternans testing in patients with heart failure (with Cobbe and Ford) and investigation of the genetic determinants and prognostic importance of adrenal corticosteroids in patients with heart failure (with Connell).
In collaboration with MacIntyre and Hole (Public Health) we are studying the relationship between deprivation and the incidence of heart failure (and subsequent prognosis) in the Renfrew-Paisley study. In conjunction with the Information and Statistics Division of the Scottish NHS (Chalmers, Redpath and Finlayson) we are evaluating population trends in morbidity and mortality in patients with heart failure.
Professor McMurray is leading a number of phase I “proof of concept” studies in heart failure with novel agents including a new inotrope (which increases the efficiency of actin-myosin cross-bridge formation), an adenosine antagonist (to improve renal function) and a renin-inhibitor in heart failure (in conjunction with Pitt, University of Michigan and left ventricular dysfunction after myocardial infarction (with Pfeffer and Solomon, Harvard University).
Professor McMurray is also involved in the leadership of large trials in heart failure, including CORONA, I-PRESERVE and RED-HF and collaborating with Briggs (Public Health) to conduct ancillary health economic analyses of these.