Prof Godfrey Smith

  • Professor of Cardiovascular Physiology (Institute of Cardiovascular and Medical Sciences)

telephone: 01413305963
email: Godfrey.Smith@glasgow.ac.uk


Examination of the subcellular processes involved in excitation-contraction coupling of cardiac muscle using biophysical and biochemical techniques. Methodologies include fluorescence microscopy, electrophysiology and confocal imaging.

 

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 85.

2013

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112 (3). pp. 424-431. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.300501)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, FL., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54 . pp. 53-64. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2012.10.017)

Kettlewell, S., Burton, F.L., Smith, G.L., and Workman, A.J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research . ISSN 0008-6363 (doi:10.1093/cvr/cvt087) (In Press)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112 (3). pp. 424-431. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.300501)

2012

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97 (10). pp. 1131-1139. ISSN 0958-0670 (doi:10.1113/expphysiol.2012.065110)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110 . pp. 1618-1627. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165 (4b). pp. 1068-1083. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2011.01531.x)

Kemi, O.J., MacQuaide, N., Hoydal, M.A., Ellingsen, O., Smith, G.L., and Wisloff, U. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227 (1). pp. 20-26. ISSN 0021-9541 (doi:10.1002/jcp.22771)

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L., and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology (17). pp. 4289-4305. ISSN 0022-3751 (doi:10.1113/jphysiol.2012.235986)

2011

Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L., and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51 (5). pp. 627-631. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2011.08.003)

Koch, L.G. et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109 (10). pp. 1162-1172. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.253807)

Kemi, O.J., Hoydal, M.A., MacQuaide, N., Haram, P.M., Koch, L.G., Britton, S.L., Ellingsen, O., Smith, G.L., and Wisloff, U. (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226 (9). pp. 2235-2243. ISSN 0021-9541 (doi:10.1002/jcp.22559)

Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108 (8). pp. 929-939. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.110.230698)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50 (3). pp. 510-512. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.11.019 )

Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1 (1). pp. 101-116. ISSN 2042-8898 (doi:10.1098/rsfs.2010.0005)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131 (2). pp. 204-220. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106 (6). pp. 1009-1022. ISSN 0300-8428 (doi:10.1007/s00395-011-0218-4)

McMurray, J.J.V., and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine . ISSN 0028-4793 (doi:10.1056/NEJMcibr1110758)

Rota, M., Biesmans, L., Macquaide, N., Heinzel, F.R., Bito, V., Smith, G.L., and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6 (10). e25100. ISSN 1932-6203 (doi:10.1371/journal.pone.0025100)

Workman, A.J., Smith, G.L., and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131 (2). pp. 221-241. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.002)

2010

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105 (2). pp. 279-287. ISSN 0300-8428 (doi:10.1007/s00395-009-0057-8)

Klauke, N., Smith, G., and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82 (2). pp. 585-592. ISSN 0003-2700 (doi:10.1021/ac901886j)

Cheng, W., Klauke, N., Smith, G., and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31 (8). pp. 1405-1413. ISSN 0173-0835

Craig, M.A., McBride, M.W., Smith, G.L., George, S.J., and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48 (6). pp. 1121-1128. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.01.017)

Eisner, D. A., George, C. H., Smith, G.L., Trafford, A. W., and Venetucci, L. A. (2010) How does CaMKII  phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences, 107 (31). E123-E123. ISSN 0027-8424 (doi:10.1073/pnas.1008809107)

Macquaide, N., Ramay, H.R., Sobie, E.A., and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588 (23). pp. 4731-4742. ISSN 0022-3751 (doi:10.1113/jphysiol.2010.193375)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289 (8). H1812-H1822. ISSN 0363-6135 (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99 (10). pp. 255-261. ISSN 0091-679X (doi:10.1016/B978-0-12-374841-6.00009-8)

Zamparelli, Carlotta, Macquaide, Niall, Colotti, Gianni, Verzili, Daniela, Seidler, Tim, Smith, G.L., and Chiancone, Emilia (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49 (1). pp. 132-141. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.03.003)

2009

Fowler, M., and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107 (6). pp. 1981-1984. ISSN 8750-7587 (doi:10.1152/japplphysiol.91168.2009)

Kettlewell, S., Seidler, T., and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflugers Archiv, 458 (4). pp. 653-660. ISSN 0031-6768 (doi:10.1007/s00424-009-0666-y)

MacQuaide, N., Dempster, J., and Smith, G.L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized Rabbit ventricular cardiomyocytes. Biophysical Journal, 96 (7). pp. 2744-2754. ISSN 0006-3495 (doi:10.1016/j.bpj.2008.12.3944)

Fowler, M.R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T., and Smith, G.L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv: European Journal of Physiology, 457 (5). pp. 1049-1060. ISSN 0031-6768 (doi:10.1007/s00424-008-0575-5)

Fowler, M.R., and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107 (6). p. 1988. ISSN 8750-7587 (doi:10.1152/japplphysiol.01088.2009)

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A., and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46 (6). pp. 891-901. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2009.02.016)

Klauke, N., Smith, G.L., and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81 (15). pp. 6390-6398. ISSN 0003-2700 (doi:10.1021/ac9008429)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53 (4). pp. 694-700. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.108.122333)

Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105 (6). pp. 527-536. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.109.199810)

2008

Kemi, O.J., Ellingsen, O., Smith, G.L., and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13 . pp. 356-368. ISSN 1093-9946 (doi:10.2741/2685)

Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L., and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93 (12). pp. 1233-1238. ISSN 0958-0670 (doi:10.1113/expphysiol.2008.043497)

Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15 (2). pp. 145-148. ISSN 1741-8267 (doi:10.1097/HJR.0b013e3282efd4e0)

Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G., and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214 (2). pp. 316-321. ISSN 0021-9541 (doi:10.1002/jcp.21197)

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45 (1). pp. 1-10. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2008.03.024)

Schjerve, Inga E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115 (9). pp. 283-293. ISSN 0143-5221 (doi:10.1042/CS20070332)

2007

Chilton, L., Giles, W.R., and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583 (1). pp. 225-236. ISSN 0022-3751 (doi:10.1113/jphysiol.2007.135038)

Caldwell, J, Burton, FL, Smith, GL, and Cobbe, SM (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18 (8). pp. 854-861. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2007.00867.x)

Hoydal, MA, Wisloff, U, Kemi, OJ, Britton, SL, Koch, LG, Smith, GL, and Ellingsen, O (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14 (2). pp. 319-325. ISSN 1741-8267

Kemi, OJ, Ellingsen, O, Ceci, M, Grimaldi, S, Smith, GL, Condorelli, G, and Wisloff, U (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43 (3). pp. 354-361. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2007.06.013)

Loughrey, CM, Otani, N, Seidler, T, Craig, MA, Matsuda, R, Kaneko, N, and Smith, GL (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76 (2). pp. 236-246. ISSN 0008-6363 (doi:10.1016/j.cardiores.2007.06.014)

MacQuaide, N, Dempster, J, and Smith, GL (2007) Measurement and Modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93 (7). pp. 2581-2595. ISSN 0006-3495 (doi:10.1529/biophysj.106.102293)

Schillinger, W et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116 (1). pp. 57-66. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.106.666008)

Seidler, T, Loughrey, CM, Zibrova, D, Kettlewell, S, Teucher, N, Kogler, H, Hasenfuss, G, and Smith, GL (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101 (10). pp. 1020-1029. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.107.154609)

Smith, G (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92 (6). pp. 973-986. ISSN 0958-0670 (doi:10.1113/expphysiol.2007.034314)

Volkers, M et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41 (2). pp. 135-143. ISSN 0143-4160 (doi:10.1016/j.ceca.2006.06.001)

Walker, NL, Burton, FL, Kettlewell, S, Smith, GL, and Cobbe, SM (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18 (8). pp. 862-868. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2007.00858.x)

Wisloff, U et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115 (24). pp. 3086-3094. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.106.675041)

2006

Colotti, G, Zamparelli, C, Verzili, D, Mella, M, Loughrey, CM, Smith, GL, and Chiancone, E (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45 (41). pp. 12519-12529. ISSN 0006-2960 (doi:10.1021/bi060416a)

Kemi, OJ, Arbo, I, Hoydal, MA, Loennechen, JP, Wisloff, U, Smith, GL, and Ellingsen, O (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188 (3-4). pp. 185-193. ISSN 1748-1708 (doi:10.1111/j.1748-1716.2006.01621.x)

Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S., and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17 (s1). S57-S63. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2006.00384.x)

2005

Currie, S, Quinn, FR, Sayeed, RA, Duncan, AM, Kettlewell, S, and Smith, GL (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39 (2). pp. 309-317. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2005.04.005)

Kettlewell, S, Most, P, Currie, S, Koch, WJ, and Smith, GL (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39 (6). pp. 900-910. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2005.06.018)

Kohl, P, Camelliti, P, Burton, FL, and Smith, GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38 (4). pp. 45-50. ISSN 0022-0736 (doi:10.1016/j.jelectrocard.2005.06.096)

Miller, SLW, Currie, S, Loughrey, CM, Kettlewell, S, Seidler, T, Reynolds, DF, Hasenfuss, G, and Smith, GL (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67 (4). pp. 667-677. ISSN 0008-6363 (doi:10.1016/j.cardiores.2005.04.023)

2004

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556 (3). pp. 919-934. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287 (3). H1149-H1159. ISSN 0363-6135 (doi:10.1152/ajpheart.00060.2004)

Currie, S, Loughrey, CM, Craig, MA, and Smith, GL (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377 (2). pp. 357-366. ISSN 0264-6021 (doi:10.1042/BJ200310431)

Kettlewell, S, Walker, NL, Cobbe, SM, Burton, FL, and Smith, GL (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89 (2). pp. 163-172. ISSN 0958-0670 (doi:10.1113/expphysiol.2003.026732)

MacEachern, KE, Smith, GL, and Nolan, AM (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31 (4). pp. 239-249. ISSN 1467-2987 (doi:10.1111/j.1467-2995.2004.00176.x)

Teucher, N et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110 (23). pp. 3553-3559. ISSN 0009-7322 (doi:10.1161/01.CIR.0000145161.48545.B3)

Wokosin, DL, Loughrey, CM, and Smith, GL (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86 (3). pp. 1726-1738. ISSN 0006-3495 (doi:10.1016/S0006-3495(04)74241-1 )

2003

Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M., and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553 (1). pp. 229-242. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.050716)

McConnell, G, Smith, GL, Girkin, JM, Gurney, AM, and Ferguson, AI (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28 (19). pp. 1742-1744. ISSN 0146-9592 (doi:10.1364/OL.28.001742)

Most, P et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278 (29). pp. 26356-26364. ISSN 0021-9258 (doi:10.1074/jbc.M303338200)

Prestle, J, Quinn, FR, and Smith, GL (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10 (11). pp. 967-981. ISSN 0929-8673

Seidler, T et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93 (2). pp. 132-139. ISSN 0009-7330 (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13 (12). pp. 3535-3560. ISSN 0218-1274 (doi:10.1142/S0218127403008843)

2002

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543 (3). pp. 859-870. ISSN 0022-3751 (doi:10.1113/jphysiol.2002.021519)

Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L., and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74 (4). pp. 908-914. ISSN 0003-2700 (doi:10.1021/ac010941+)

Neary, P., Duncan, A.M., Cobbe, S.M., and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv: European Journal of Physiology, 444 (3). pp. 360-371. ISSN 0031-6768 (doi:10.1007/s00424-002-0794-0)

Ng, G.A., Hicks, M.N., Cobbe, S.M., and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv: European Journal of Physiology, 444 (4). pp. 513-522. ISSN 0031-6768 (doi:10.1007/s00424-002-0848-3)

Wisloff, U, Loennechen, JP, Currie, S, Smith, GL, and Ellingsen, O (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54 (1). pp. 162-174. ISSN 0008-6363 (doi:10.1016/S0008-6363(01)00565-X)

2001

Smith, G.L., and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534 (1). pp. 37-47. ISSN 0022-3751 (doi:10.1111/j.1469-7793.2001.00037.x)

Most, P et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98 (24). pp. 13889-13894. ISSN 0027-8424 (doi:10.1073/pnas.241393598)

Prestle, J, Janssen, PML, Janssen, AP, Zeitz, O, Lehnart, SE, Bruce, L, Smith, GL, and Hasenfuss, G (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88 (2). pp. 188-194. ISSN 0009-7330

Wisloff, U, Loennechen, JP, Falck, G, Beisvag, V, Currie, S, Smith, G, and Ellingsen, O (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50 (3). pp. 495-508. (doi:10.1016/S0008-6363(01)00210-3)

This list was generated on Thu May 2 20:23:07 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • The role of RyR cluster morphology in Ca2+ homeostasis
    British Heart Foundation
    2013 - 2017
     
  • The role of RyR cluster morphology in Ca2+ homeostasis
    British Heart Foundation
    2013 - 2017
     
  • Investigating the therapeutic potential of cathepsin-L inhibition to limit ischaemia-reperfusion injury in the heart
    Scottish Executive Health Department
    2013 - 2015
     
  • Electrophysiology Chip on a Microfluidic Platform
    BBSRC
    2011 - 2014
     
  • Cardiac CaMK in heart failure and exercise training
    British Heart Foundation
    2010 - 2013
     
  • KTA-EPSRC:Design and production of demo prototype of CellOPTIQ
    Engineering & Physical Sciences Research Council
    2009 - 2012
     
  • Production of cardiomyocytes from human embryonic stem cells
    Stem Cells for Safer Medicines
    2009 - 2010
     
  • EUTrigTreat - Indentification and therapeutic targeting of common arrhythmia trigger mechanisms
    European Commission
    2009 - 2014
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Atrial remodelling of calcium handling and electrophysiology in heart failure.
    British Heart Foundation
    2009 - 2013
     
  • Hypothermia - Competence programme in diving
    The Norwegian University of Science and Technology
    2008 - 2008
     
  • Scottish Universities Life Sciences Alliance (SULSA)- Cell Biology
    Scottish Funding Council
    2008 - 2015
     
  • Does ACE2 have a protective role in the heart? Systematic analysis of ACE2 in a disease model
    British Heart Foundation
    2007 - 2010
     
  • Targeted disruption of sarcoplasmic reticulum mediated Ca2+ handling and diastolic dysfunction: A comaprison between isolated cardiomyocytes and the whole heart.
    Heart Research UK
    2007 - 2009
     
  • The effect of Ca2+ microdomains on Ca2+ dependent processes in cardiac ventricular myocytes
    British Heart Foundation
    2007 - 2010
     
  • Heartwave II Microvolt T-wave alternans system
    The Norwegian University of Science and Technology
    2007 - 2007
     
  • Investigating the role of intracellular calcium in the left ventricular diastolic dysfunction
    Medical Research Scotland
    2006 - 2008
     
  • The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
    British Heart Foundation
    2006 - 2009
     
  • Unravelling the effect of cadherin dysregulation in the heart
    Wellcome Trust
    2006 - 2007
     
  • Cellular Basis of Arrhythmias:The Inter-Relationship between Ca2+ Transients and Ca2+ Waves in Cardiac Muscle
    British Heart Foundation
    2006 - 2009
     
  • Effect of Acidosis on the cardiac atrio-ventricular node
    British Heart Foundation
    2005 - 2006
     
  • Investigation of calcium signalling in sarcoplasmic riticulum of cardiac myocytes using a novel targeted reporter
    BBSRC
    2005 - 2008
     
  • Atrioventricular nodal function in a rabbit model of chronic heart failure
    British Heart Foundation
    2005 - 2007
     
  • Electrophysiology of ventricular myofybroblasts within myocardial infarction scars of rabbit hearts
    British Heart Foundation
    2005 - 2005
     
  • High Fidelity Phenotyping combined with genomics, proteomics and metabonomics close to the patient
    British Heart Foundation
    2004 - 2008
     
  • A longitudinal study of myocardial remodelling following infarction in the rabbit heart
    British Heart Foundation
    2004 - 2009
     
  • A study of the subcellular actions of sorcin in ventricular cardiac muscle
    British Heart Foundation
    2004 - 2007
     
  • Factors affecting the success of defibrillation in ischaemia (Dr Jane Caldwell)
    British Heart Foundation
    2004 - 2007
     
  • A study of the mechanisms and dynamics of action potential adaptation to increase in heart rate
    British Heart Foundation
    2002 - 2005
     
  • The role of FK binding proteins in the modulation of excitation-contraction coupling in cardiac muscle
    Wellcome Trust
    2002 - 2005
     

Editorial Board

  • 1999 - ongoing: Experimental Physiology - Journal Editor

Grant Advisory Board

  • 2001 - 2005: British Heart Foundation - Project Grants Committee

Invited International Presentations

  • 2004: The International Society for Cardiovascular Research Symposium - Heart failure, disorders of Ca handling
  • 2004: Trondheim, Norway - "Cellular Biology of Exercise Training in Cardiovascular Disease"
  • 2004: The British Society for Cardiovascular Research meeting - Integrative cardiovascular pathophysiology in gene-modified models.
  • 2004: Lundsbrunn Spa, Sweden - Scandinavian Physiological Society Meeting on: Transport and membrane trafficking in cells
  • 2002: Lillehamer, Norway - Annual meeting of the Norwegian Cardiology Society
  • 2002: London, England - The British Society for Cardiovascular Research meeting on: Ion Channels and Transporters in Cardiovascular cell growth
  • 2002: London, England - The Physiological Society on: Cardiac electrophysiology, heterogeneity in the heart
  • 2002: Cavalese, Italy - 12th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease
  • 2002: London, England - The Physiological Society Symposium on the Athletes Heart

Prizes, Awards and Distinctions

  • 2005: Physiological Society, G.L. Brown Prize Lecture

Professional Learned Society

  • 2003 - ongoing: British Cardiac Society - Member
  • 1995 - ongoing: British Society for Cardiovascular Research - Member
  • 1993 - ongoing: Biophysical Society - USA - Member
  • 1986 - ongoing: Physiological Society - Grants Subcommittee 1999-2005, Dale and Rushton Fund Co-treasurer 1999-2005, Further Education Subcommittee 1999-2002, Memberships Committee (Chair) 2002-05, Council Member 1998-2004

Research Fellowship

  • 1988 - 1991: British Heart Foundation Fellowship