Professor Godfrey Smith

  • Professor of Cardiovascular Physiology (Institute of Cardiovascular and Medical Sciences)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413305963
email: Godfrey.Smith@glasgow.ac.uk

Research interests

Examination of the subcellular processes involved in excitation-contraction coupling of cardiac muscle using biophysical and biochemical techniques. Methodologies include fluorescence microscopy, electrophysiology and confocal imaging.

 

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • INVESTIGATING THE ROLE OF RUNX1 IN THE HEART POST-MYOCARDIAL INFARCTION
    Medical Research Council
    2015 - 2018
     
  • Investigating the mechanisms of low-voltage defibrillation and its application to the human ventricle to facilitate its translation into the clinic
    British Heart Foundation
    2015 - 2017
     
  • Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities
    National Centre for Replacement,Refinement and Reduction of
    2015 - 2018
     
  • Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities
    National Centre for Replacement,Refinement and Reduction of
    2014 - 2014
     
  • Monitoring contractlitiy of bio-realistic human cardiac tissue in-vitro ref CRACK IT Challenges 35587-259131
    National Centre for Replacement,Refinement and Reduction of
    2014 - 2014
     
  • Human atrial action potential alternans and afterdepolarisations: electrophysiological and calcium-cycling mechanisms and effects of myocardial disease
    British Heart Foundation
    2013 - 2016
     
  • The role of RyR cluster morphology in Ca2+ homeostasis
    British Heart Foundation
    2013 - 2017
     
  • Investigating the therapeutic potential of cathepsin-L inhibition to limit ischaemia-reperfusion injury in the heart
    Scottish Executive Health Department
    2013 - 2015
     
  • IAA-EPSRC: Upgrade of cellOPTIQ function to allow simultaneous multiple fluorescence measurements
    Engineering & Physical Sciences Research Council
    2012 - 2015
     
  • Electrophysiology Chip on a Microfluidic Platform
    BBSRC
    2011 - 2014
     
  • Cardiac CaMK in heart failure and exercise training
    British Heart Foundation
    2010 - 2013
     
  • KTA-EPSRC:Design and production of demo prototype of CellOPTIQ
    Engineering & Physical Sciences Research Council
    2009 - 2012
     
  • Production of cardiomyocytes from human embryonic stem cells
    Stem Cells for Safer Medicines
    2009 - 2010
     
  • EUTrigTreat - Indentification and therapeutic targeting of common arrhythmia trigger mechanisms
    European Commission
    2009 - 2014
     
  • Atrial remodelling of calcium handling and electrophysiology in heart failure.
    British Heart Foundation
    2009 - 2013
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Hypothermia - Competence programme in diving
    The Norwegian University of Science and Technology
    2008 - 2008
     
  • Scottish Universities Life Sciences Alliance (SULSA)- Cell Biology
    Scottish Funding Council
    2008 - 2015
     
  • Does ACE2 have a protective role in the heart? Systematic analysis of ACE2 in a disease model
    British Heart Foundation
    2007 - 2010
     
  • Targeted disruption of sarcoplasmic reticulum mediated Ca2+ handling and diastolic dysfunction: A comaprison between isolated cardiomyocytes and the whole heart.
    Heart Research UK
    2007 - 2009
     
  • The effect of Ca2+ microdomains on Ca2+ dependent processes in cardiac ventricular myocytes
    British Heart Foundation
    2007 - 2010
     
  • Heartwave II Microvolt T-wave alternans system
    The Norwegian University of Science and Technology
    2007 - 2007
     
  • Investigating the role of intracellular calcium in the left ventricular diastolic dysfunction
    Medical Research Scotland
    2006 - 2008
     
  • The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
    British Heart Foundation
    2006 - 2009
     
  • Unravelling the effect of cadherin dysregulation in the heart
    Wellcome Trust
    2006 - 2007
     
  • Cellular Basis of Arrhythmias:The Inter-Relationship between Ca2+ Transients and Ca2+ Waves in Cardiac Muscle
    British Heart Foundation
    2006 - 2009
     
  • Effect of Acidosis on the cardiac atrio-ventricular node
    British Heart Foundation
    2005 - 2006
     
  • Investigation of calcium signalling in sarcoplasmic riticulum of cardiac myocytes using a novel targeted reporter
    BBSRC
    2005 - 2008
     
  • Atrioventricular nodal function in a rabbit model of chronic heart failure
    British Heart Foundation
    2005 - 2007
     
  • Electrophysiology of ventricular myofybroblasts within myocardial infarction scars of rabbit hearts
    British Heart Foundation
    2005 - 2005
     
  • High Fidelity Phenotyping combined with genomics, proteomics and metabonomics close to the patient
    British Heart Foundation
    2004 - 2008
     
  • A longitudinal study of myocardial remodelling following infarction in the rabbit heart
    British Heart Foundation
    2004 - 2009
     
  • A study of the subcellular actions of sorcin in ventricular cardiac muscle
    British Heart Foundation
    2004 - 2007
     
  • Factors affecting the success of defibrillation in ischaemia (Dr Jane Caldwell)
    British Heart Foundation
    2004 - 2007
     
  • A study of the mechanisms and dynamics of action potential adaptation to increase in heart rate
    British Heart Foundation
    2002 - 2005
     
  • The role of FK binding proteins in the modulation of excitation-contraction coupling in cardiac muscle
    Wellcome Trust
    2002 - 2005
     

Additional information

Editorial Board

  • 1999 - ongoing: Experimental Physiology - Journal Editor

Grant Advisory Board

  • 2001 - 2005: British Heart Foundation - Project Grants Committee

Invited International Presentations

  • 2004: The International Society for Cardiovascular Research Symposium - Heart failure, disorders of Ca handling
  • 2004: Trondheim, Norway - "Cellular Biology of Exercise Training in Cardiovascular Disease"
  • 2004: The British Society for Cardiovascular Research meeting - Integrative cardiovascular pathophysiology in gene-modified models.
  • 2004: Lundsbrunn Spa, Sweden - Scandinavian Physiological Society Meeting on: Transport and membrane trafficking in cells
  • 2002: Lillehamer, Norway - Annual meeting of the Norwegian Cardiology Society
  • 2002: London, England - The British Society for Cardiovascular Research meeting on: Ion Channels and Transporters in Cardiovascular cell growth
  • 2002: London, England - The Physiological Society on: Cardiac electrophysiology, heterogeneity in the heart
  • 2002: Cavalese, Italy - 12th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease
  • 2002: London, England - The Physiological Society Symposium on the Athletes Heart

Prizes, Awards and Distinctions

  • 2005: Physiological Society, G.L. Brown Prize Lecture

Professional Learned Society

  • 2003 - ongoing: British Cardiac Society - Member
  • 1995 - ongoing: British Society for Cardiovascular Research - Member
  • 1993 - ongoing: Biophysical Society - USA - Member
  • 1986 - ongoing: Physiological Society - Grants Subcommittee 1999-2005, Dale and Rushton Fund Co-treasurer 1999-2005, Further Education Subcommittee 1999-2002, Memberships Committee (Chair) 2002-05, Council Member 1998-2004

Research Fellowship

  • 1988 - 1991: British Heart Foundation Fellowship

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1994
Number of items: 102.

2015

McArthur, L., Chilton, L., Smith, G. L., and Nicklin, S. A. (2015) Electrical consequences of cardiac myocyte: fibroblast coupling. Biochemical Society Transactions, 43(3), pp. 513-518. (doi:10.1042/BST20150035)

Smith, G. L., and MacQuaide, N. (2015) The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT. Circulation Research, 116(8), pp. 1284-1286. (doi:10.1161/CIRCRESAHA.115.306298) (PMID:25858058)

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L., and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi:10.1002/jbio.201300109)

2014

Campbell, A. S., Johnstone, S. R., Baillie, G. S., and Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current. Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi:10.1016/j.yjmcc.2014.09.030)

Boyman, L., Chikando, A. C., Williams, G. S.B., Khairallah, R. J., Kettlewell, S., Ward, C. W., Smith, G. L., Kao, J. P.Y., and Lederer, W. J. (2014) Calcium movement in cardiac mitochondria. Biophysical Journal, 107(6), pp. 1289-1301. (doi:10.1016/j.bpj.2014.07.045)

Haviland, S., Cleemann, L., Kettlewell, S., Smith, G. L., and Morad, M. (2014) Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe mitycam-E31Q. Cell Calcium, 56(3), pp. 133-146. (doi:10.1016/j.ceca.2014.06.001) (PMID:24994483)

O-Uchi, J. et al. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxidants and Redox Signaling, 21(6), pp. 863-879. (doi:10.1089/ars.2013.5394)

Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G., Sidor, A., Abraham, T. P., and O'Rourke, B. (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circulation Research, 115(1), pp. 44-54. (doi:10.1161/CIRCRESAHA.115.303062)

Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L., and Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica, 210(4), pp. 854-864. (doi:10.1111/apha.12238)

Hohendanner, F., Walther, S., Maxwell, J. T., Kettlewell, S., Awad, S., Smith, G., Lonchyna, V. A., and Blatter, L. A. (2014) Inositol-1,4,5-trisphosphate induced Ca2+release and excitation-contraction coupling in atrial myocytes from normal and failing hearts. Journal of Physiology, 593(6), pp. 1459-1477. (doi:10.1113/jphysiol.2014.283226) (PMID:25416623)

Campbell, A. S., Burton, F. L., Baillie, G. L., and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H., and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi:10.3389/fphys.2014.00233)

2013

Hoydal, M.A., Kaurstad, G., Rolim, N.P., Johnsen, A.B., Alves, M., Koch, L.G., Britton, S.L., Stolen, T.O., Smith, G.L., and Wisloff, U. (2013) High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of Applied Physiology, 115(12), pp. 1788-1795. (doi:10.1152/japplphysiol.00312.2013)

Kettlewell, S., Burton, F. L., Smith, G. L., and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087) (PMCID:PMC3687753)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112(3), pp. 424-431. (doi:10.1161/CIRCRESAHA.111.300501)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, F., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi:10.1016/j.yjmcc.2012.10.017)

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi:10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

2012

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi:10.1113/expphysiol.2012.065110)

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L., and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi:10.1113/jphysiol.2012.235986)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi:10.1161/CIRCRESAHA.111.262337)

Kemi, O. J., MacQuaide, N., Hoydal, M. A., Ellingsen, O., Smith, G. L., and Wisloff, U. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227(1), pp. 20-26. (doi:10.1002/jcp.22771)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi:10.1111/j.1476-5381.2011.01531.x)

2011

Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L., and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51(5), pp. 627-631. (doi:10.1016/j.yjmcc.2011.08.003)

Koch, L. G. et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109(10), pp. 1162-1172. (doi:10.1161/CIRCRESAHA.111.253807)

Kemi, O. J., Hoydal, M. A., MacQuaide, N., Haram, P. M., Koch, L. G., Britton, S. L., Ellingsen, O., Smith, G. L., and Wisloff, U. (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226(9), pp. 2235-2243. (doi:10.1002/jcp.22559)

Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108(8), pp. 929-939. (doi:10.1161/CIRCRESAHA.110.230698)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi:10.1016/j.yjmcc.2010.11.019 )

Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1(1), pp. 101-116. (doi:10.1098/rsfs.2010.0005)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi:10.1007/s00395-011-0218-4)

McMurray, J.J.V., and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine, (doi:10.1056/NEJMcibr1110758)

Rota, M., Biesmans, L., MacQuaide, N., Heinzel, F.R., Bito, V., Smith, G.L., and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6(10), e25100. (doi:10.1371/journal.pone.0025100)

Workman, A.J., Smith, G.L., and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi:10.1016/j.pharmthera.2011.02.002)

2010

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi:10.1007/s00395-009-0057-8)

Craig, M. A., McBride, M. W., Smith, G., George, S., and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6), pp. 1121-1128. (doi:10.1016/j.yjmcc.2010.01.017)

Klauke, N., Smith, G., and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82(2), pp. 585-592. (doi:10.1021/ac901886j)

Cheng, W., Klauke, N., Smith, G., and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31(8), pp. 1405-1413.

Eisner, D. A., George, C. H., Smith, G.L., Trafford, A. W., and Venetucci, L. A. (2010) How does CaMKII  phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences of the United States of America, 107(31), E123-E123. (doi:10.1073/pnas.1008809107)

MacQuaide, N., Ramay, H.R., Sobie, E.A., and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588(23), pp. 4731-4742. (doi:10.1113/jphysiol.2010.193375)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi:10.1016/B978-0-12-374841-6.00009-8)

Zamparelli, C., MacQuaide, N., Colotti, G., Verzili, D., Seidler, T., Smith, G.L., and Chiancone, E. (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49(1), pp. 132-141. (doi:10.1016/j.yjmcc.2010.03.003)

2009

Fowler, M., and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), pp. 1981-1984. (doi:10.1152/japplphysiol.91168.2009)

Kettlewell, S., Seidler, T., and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflügers Archiv - European Journal of Physiology, 458(4), pp. 653-660. (doi:10.1007/s00424-009-0666-y)

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A., and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi:10.1016/j.yjmcc.2009.02.016)

MacQuaide, N., Dempster, J., and Smith, G.L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized rabbit ventricular cardiomyocytes. Biophysical Journal, 96(7), pp. 2744-2754. (doi:10.1016/j.bpj.2008.12.3944)

Fowler, M. R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T., and Smith, G. L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv - European Journal of Physiology, 457(5), pp. 1049-1060. (doi:10.1007/s00424-008-0575-5)

Fowler, M.R., and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), p. 1988. (doi:10.1152/japplphysiol.01088.2009)

Klauke, N., Smith, G.L., and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81(15), pp. 6390-6398. (doi:10.1021/ac9008429)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105(6), pp. 527-536. (doi:10.1161/CIRCRESAHA.109.199810)

2008

Kemi, O.J., Ellingsen, O., Smith, G.L., and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13, pp. 356-368. (doi:10.2741/2685)

Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L., and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93(12), pp. 1233-1238. (doi:10.1113/expphysiol.2008.043497)

Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15(2), pp. 145-148. (doi:10.1097/HJR.0b013e3282efd4e0)

Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G., and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214(2), pp. 316-321. (doi:10.1002/jcp.21197)

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi:10.1016/j.yjmcc.2008.03.024)

Schjerve, I. E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115(9), pp. 283-293. (doi:10.1042/CS20070332)

2007

Chilton, L., Giles, W.R., and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583(1), pp. 225-236. (doi:10.1113/jphysiol.2007.135038)

Klauke, N., Smith, G., and Cooper, J. M. (2007) Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. Lab on a Chip, 7, pp. 731-739. (doi:10.1039/b706175g)

Caldwell, J., Burton, F., Smith, G., and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi:10.1111/j.1540-8167.2007.00867.x)

Hoydal, M., Wisloff, U., Kemi, O., Britton, S., Koch, L., Smith, G., and Ellingsen, O. (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14(2), pp. 319-325.

Kemi, O., Ellingsen, O., Ceci, M., Grimaldi, S., Smith, G., Condorelli, G., and Wisloff, U. (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43(3), pp. 354-361. (doi:10.1016/j.yjmcc.2007.06.013)

Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N., and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi:10.1016/j.cardiores.2007.06.014)

MacQuaide, N., Dempster, J., and Smith, G. (2007) Measurement and Modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93(7), pp. 2581-2595. (doi:10.1529/biophysj.106.102293)

Schillinger, W. et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116(1), pp. 57-66. (doi:10.1161/CIRCULATIONAHA.106.666008)

Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G., and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi:10.1161/CIRCRESAHA.107.154609)

Smith, G. (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92(6), pp. 973-986. (doi:10.1113/expphysiol.2007.034314)

Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi:10.1016/j.ceca.2006.06.001)

Walker, N., Burton, F., Kettlewell, S., Smith, G., and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi:10.1111/j.1540-8167.2007.00858.x)

Wisloff, U. et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115(24), pp. 3086-3094. (doi:10.1161/CIRCULATIONAHA.106.675041)

2006

Cheng, W., Klauke, N., Sedgwick, H., Smith, G. L., and Cooper, J. M. (2006) Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. Lab on a Chip, 6(11), pp. 1424-1431. (doi:10.1039/b608202e)

Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G., and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi:10.1021/bi060416a)

Kemi, O., Arbo, I., Hoydal, M., Loennechen, J., Wisloff, U., Smith, G., and Ellingsen, O. (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188(3-4), pp. 185-193. (doi:10.1111/j.1748-1716.2006.01621.x)

Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S., and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17(s1), S57-S63. (doi:10.1111/j.1540-8167.2006.00384.x)

2005

Currie, S., Quinn, F., Sayeed, R., Duncan, A., Kettlewell, S., and Smith, G. (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39(2), pp. 309-317. (doi:10.1016/j.yjmcc.2005.04.005)

Kettlewell, S., Most, P., Currie, S., Koch, W., and Smith, G. (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39(6), pp. 900-910. (doi:10.1016/j.yjmcc.2005.06.018)

Kohl, P., Camelliti, P., Burton, F., and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi:10.1016/j.jelectrocard.2005.06.096)

Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G., and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi:10.1016/j.cardiores.2005.04.023)

2004

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi:10.1152/ajpheart.00060.2004)

Currie, S., Loughrey, C., Craig, M., and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi:10.1042/BJ200310431)

Kettlewell, S., Walker, N., Cobbe, S., Burton, F., and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi:10.1113/expphysiol.2003.026732)

MacEachern, K., Smith, G., and Nolan, A. (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31(4), pp. 239-249. (doi:10.1111/j.1467-2995.2004.00176.x)

Teucher, N. et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110(23), pp. 3553-3559. (doi:10.1161/01.CIR.0000145161.48545.B3)

Wokosin, D., Loughrey, C., and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi:10.1016/S0006-3495(04)74241-1 )

2003

Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M., and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553(1), pp. 229-242. (doi:10.1113/jphysiol.2003.050716)

McConnell, G., Smith, G., Girkin, J., Gurney, A., and Ferguson, A. (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28(19), pp. 1742-1744. (doi:10.1364/OL.28.001742)

Most, P. et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278(29), pp. 26356-26364. (doi:10.1074/jbc.M303338200)

Prestle, J., Quinn, F., and Smith, G. (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10(11), pp. 967-981.

Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi:10.1142/S0218127403008843)

2002

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi:10.1113/jphysiol.2002.021519)

Neary, P., Duncan, A.M., Cobbe, S.M., and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv - European Journal of Physiology, 444(3), pp. 360-371. (doi:10.1007/s00424-002-0794-0)

Ng, G.A., Hicks, M.N., Cobbe, S.M., and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv - European Journal of Physiology, 444(4), pp. 513-522. (doi:10.1007/s00424-002-0848-3)

Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L., and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74(4), pp. 908-914. (doi:10.1021/ac010941+)

Wisloff, U., Loennechen, J., Currie, S., Smith, G., and Ellingsen, O. (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54(1), pp. 162-174. (doi:10.1016/S0008-6363(01)00565-X)

2001

Smith, G.L., and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534(1), pp. 37-47. (doi:10.1111/j.1469-7793.2001.00037.x)

Most, P. et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98(24), pp. 13889-13894. (doi:10.1073/pnas.241393598)

Prestle, J., Janssen, P., Janssen, A., Zeitz, O., Lehnart, S., Bruce, L., Smith, G., and Hasenfuss, G. (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88(2), pp. 188-194.

Wisloff, U., Loennechen, J., Falck, G., Beisvag, V., Currie, S., Smith, G., and Ellingsen, O. (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50(3), pp. 495-508. (doi:10.1016/S0008-6363(01)00210-3)

1994

MacFarlane, N.G., Miller, D.J., Smith, G.L., and Steele, D.S. (1994) Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research, 28(11), pp. 1647-1652. (doi:10.1093/cvr/28.11.1647) (PMID:7842458)

This list was generated on Fri Aug 28 16:05:12 2015 BST.
Number of items: 102.

Articles

McArthur, L., Chilton, L., Smith, G. L., and Nicklin, S. A. (2015) Electrical consequences of cardiac myocyte: fibroblast coupling. Biochemical Society Transactions, 43(3), pp. 513-518. (doi:10.1042/BST20150035)

Smith, G. L., and MacQuaide, N. (2015) The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT. Circulation Research, 116(8), pp. 1284-1286. (doi:10.1161/CIRCRESAHA.115.306298) (PMID:25858058)

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L., and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi:10.1002/jbio.201300109)

Campbell, A. S., Johnstone, S. R., Baillie, G. S., and Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current. Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi:10.1016/j.yjmcc.2014.09.030)

Boyman, L., Chikando, A. C., Williams, G. S.B., Khairallah, R. J., Kettlewell, S., Ward, C. W., Smith, G. L., Kao, J. P.Y., and Lederer, W. J. (2014) Calcium movement in cardiac mitochondria. Biophysical Journal, 107(6), pp. 1289-1301. (doi:10.1016/j.bpj.2014.07.045)

Haviland, S., Cleemann, L., Kettlewell, S., Smith, G. L., and Morad, M. (2014) Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe mitycam-E31Q. Cell Calcium, 56(3), pp. 133-146. (doi:10.1016/j.ceca.2014.06.001) (PMID:24994483)

O-Uchi, J. et al. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxidants and Redox Signaling, 21(6), pp. 863-879. (doi:10.1089/ars.2013.5394)

Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G., Sidor, A., Abraham, T. P., and O'Rourke, B. (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circulation Research, 115(1), pp. 44-54. (doi:10.1161/CIRCRESAHA.115.303062)

Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L., and Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica, 210(4), pp. 854-864. (doi:10.1111/apha.12238)

Hohendanner, F., Walther, S., Maxwell, J. T., Kettlewell, S., Awad, S., Smith, G., Lonchyna, V. A., and Blatter, L. A. (2014) Inositol-1,4,5-trisphosphate induced Ca2+release and excitation-contraction coupling in atrial myocytes from normal and failing hearts. Journal of Physiology, 593(6), pp. 1459-1477. (doi:10.1113/jphysiol.2014.283226) (PMID:25416623)

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H., and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi:10.3389/fphys.2014.00233)

Hoydal, M.A., Kaurstad, G., Rolim, N.P., Johnsen, A.B., Alves, M., Koch, L.G., Britton, S.L., Stolen, T.O., Smith, G.L., and Wisloff, U. (2013) High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of Applied Physiology, 115(12), pp. 1788-1795. (doi:10.1152/japplphysiol.00312.2013)

Kettlewell, S., Burton, F. L., Smith, G. L., and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087) (PMCID:PMC3687753)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112(3), pp. 424-431. (doi:10.1161/CIRCRESAHA.111.300501)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, F., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi:10.1016/j.yjmcc.2012.10.017)

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi:10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi:10.1113/expphysiol.2012.065110)

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L., and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi:10.1113/jphysiol.2012.235986)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi:10.1161/CIRCRESAHA.111.262337)

Kemi, O. J., MacQuaide, N., Hoydal, M. A., Ellingsen, O., Smith, G. L., and Wisloff, U. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227(1), pp. 20-26. (doi:10.1002/jcp.22771)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi:10.1111/j.1476-5381.2011.01531.x)

Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L., and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51(5), pp. 627-631. (doi:10.1016/j.yjmcc.2011.08.003)

Koch, L. G. et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109(10), pp. 1162-1172. (doi:10.1161/CIRCRESAHA.111.253807)

Kemi, O. J., Hoydal, M. A., MacQuaide, N., Haram, P. M., Koch, L. G., Britton, S. L., Ellingsen, O., Smith, G. L., and Wisloff, U. (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226(9), pp. 2235-2243. (doi:10.1002/jcp.22559)

Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108(8), pp. 929-939. (doi:10.1161/CIRCRESAHA.110.230698)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi:10.1016/j.yjmcc.2010.11.019 )

Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1(1), pp. 101-116. (doi:10.1098/rsfs.2010.0005)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi:10.1007/s00395-011-0218-4)

McMurray, J.J.V., and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine, (doi:10.1056/NEJMcibr1110758)

Rota, M., Biesmans, L., MacQuaide, N., Heinzel, F.R., Bito, V., Smith, G.L., and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6(10), e25100. (doi:10.1371/journal.pone.0025100)

Workman, A.J., Smith, G.L., and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi:10.1016/j.pharmthera.2011.02.002)

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi:10.1007/s00395-009-0057-8)

Craig, M. A., McBride, M. W., Smith, G., George, S., and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6), pp. 1121-1128. (doi:10.1016/j.yjmcc.2010.01.017)

Klauke, N., Smith, G., and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82(2), pp. 585-592. (doi:10.1021/ac901886j)

Cheng, W., Klauke, N., Smith, G., and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31(8), pp. 1405-1413.

Eisner, D. A., George, C. H., Smith, G.L., Trafford, A. W., and Venetucci, L. A. (2010) How does CaMKII  phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences of the United States of America, 107(31), E123-E123. (doi:10.1073/pnas.1008809107)

MacQuaide, N., Ramay, H.R., Sobie, E.A., and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588(23), pp. 4731-4742. (doi:10.1113/jphysiol.2010.193375)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi:10.1016/B978-0-12-374841-6.00009-8)

Zamparelli, C., MacQuaide, N., Colotti, G., Verzili, D., Seidler, T., Smith, G.L., and Chiancone, E. (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49(1), pp. 132-141. (doi:10.1016/j.yjmcc.2010.03.003)

Fowler, M., and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), pp. 1981-1984. (doi:10.1152/japplphysiol.91168.2009)

Kettlewell, S., Seidler, T., and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflügers Archiv - European Journal of Physiology, 458(4), pp. 653-660. (doi:10.1007/s00424-009-0666-y)

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A., and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi:10.1016/j.yjmcc.2009.02.016)

MacQuaide, N., Dempster, J., and Smith, G.L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized rabbit ventricular cardiomyocytes. Biophysical Journal, 96(7), pp. 2744-2754. (doi:10.1016/j.bpj.2008.12.3944)

Fowler, M. R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T., and Smith, G. L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv - European Journal of Physiology, 457(5), pp. 1049-1060. (doi:10.1007/s00424-008-0575-5)

Fowler, M.R., and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), p. 1988. (doi:10.1152/japplphysiol.01088.2009)

Klauke, N., Smith, G.L., and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81(15), pp. 6390-6398. (doi:10.1021/ac9008429)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105(6), pp. 527-536. (doi:10.1161/CIRCRESAHA.109.199810)

Kemi, O.J., Ellingsen, O., Smith, G.L., and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13, pp. 356-368. (doi:10.2741/2685)

Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L., and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93(12), pp. 1233-1238. (doi:10.1113/expphysiol.2008.043497)

Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15(2), pp. 145-148. (doi:10.1097/HJR.0b013e3282efd4e0)

Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G., and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214(2), pp. 316-321. (doi:10.1002/jcp.21197)

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi:10.1016/j.yjmcc.2008.03.024)

Schjerve, I. E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115(9), pp. 283-293. (doi:10.1042/CS20070332)

Chilton, L., Giles, W.R., and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583(1), pp. 225-236. (doi:10.1113/jphysiol.2007.135038)

Klauke, N., Smith, G., and Cooper, J. M. (2007) Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. Lab on a Chip, 7, pp. 731-739. (doi:10.1039/b706175g)

Caldwell, J., Burton, F., Smith, G., and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi:10.1111/j.1540-8167.2007.00867.x)

Hoydal, M., Wisloff, U., Kemi, O., Britton, S., Koch, L., Smith, G., and Ellingsen, O. (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14(2), pp. 319-325.

Kemi, O., Ellingsen, O., Ceci, M., Grimaldi, S., Smith, G., Condorelli, G., and Wisloff, U. (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43(3), pp. 354-361. (doi:10.1016/j.yjmcc.2007.06.013)

Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N., and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi:10.1016/j.cardiores.2007.06.014)

MacQuaide, N., Dempster, J., and Smith, G. (2007) Measurement and Modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93(7), pp. 2581-2595. (doi:10.1529/biophysj.106.102293)

Schillinger, W. et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116(1), pp. 57-66. (doi:10.1161/CIRCULATIONAHA.106.666008)

Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G., and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi:10.1161/CIRCRESAHA.107.154609)

Smith, G. (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92(6), pp. 973-986. (doi:10.1113/expphysiol.2007.034314)

Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi:10.1016/j.ceca.2006.06.001)

Walker, N., Burton, F., Kettlewell, S., Smith, G., and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi:10.1111/j.1540-8167.2007.00858.x)

Wisloff, U. et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115(24), pp. 3086-3094. (doi:10.1161/CIRCULATIONAHA.106.675041)

Cheng, W., Klauke, N., Sedgwick, H., Smith, G. L., and Cooper, J. M. (2006) Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. Lab on a Chip, 6(11), pp. 1424-1431. (doi:10.1039/b608202e)

Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G., and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi:10.1021/bi060416a)

Kemi, O., Arbo, I., Hoydal, M., Loennechen, J., Wisloff, U., Smith, G., and Ellingsen, O. (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188(3-4), pp. 185-193. (doi:10.1111/j.1748-1716.2006.01621.x)

Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S., and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17(s1), S57-S63. (doi:10.1111/j.1540-8167.2006.00384.x)

Currie, S., Quinn, F., Sayeed, R., Duncan, A., Kettlewell, S., and Smith, G. (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39(2), pp. 309-317. (doi:10.1016/j.yjmcc.2005.04.005)

Kettlewell, S., Most, P., Currie, S., Koch, W., and Smith, G. (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39(6), pp. 900-910. (doi:10.1016/j.yjmcc.2005.06.018)

Kohl, P., Camelliti, P., Burton, F., and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi:10.1016/j.jelectrocard.2005.06.096)

Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G., and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi:10.1016/j.cardiores.2005.04.023)

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi:10.1152/ajpheart.00060.2004)

Currie, S., Loughrey, C., Craig, M., and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi:10.1042/BJ200310431)

Kettlewell, S., Walker, N., Cobbe, S., Burton, F., and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi:10.1113/expphysiol.2003.026732)

MacEachern, K., Smith, G., and Nolan, A. (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31(4), pp. 239-249. (doi:10.1111/j.1467-2995.2004.00176.x)

Teucher, N. et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110(23), pp. 3553-3559. (doi:10.1161/01.CIR.0000145161.48545.B3)

Wokosin, D., Loughrey, C., and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi:10.1016/S0006-3495(04)74241-1 )

Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M., and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553(1), pp. 229-242. (doi:10.1113/jphysiol.2003.050716)

McConnell, G., Smith, G., Girkin, J., Gurney, A., and Ferguson, A. (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28(19), pp. 1742-1744. (doi:10.1364/OL.28.001742)

Most, P. et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278(29), pp. 26356-26364. (doi:10.1074/jbc.M303338200)

Prestle, J., Quinn, F., and Smith, G. (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10(11), pp. 967-981.

Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi:10.1142/S0218127403008843)

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi:10.1113/jphysiol.2002.021519)

Neary, P., Duncan, A.M., Cobbe, S.M., and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv - European Journal of Physiology, 444(3), pp. 360-371. (doi:10.1007/s00424-002-0794-0)

Ng, G.A., Hicks, M.N., Cobbe, S.M., and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv - European Journal of Physiology, 444(4), pp. 513-522. (doi:10.1007/s00424-002-0848-3)

Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L., and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74(4), pp. 908-914. (doi:10.1021/ac010941+)

Wisloff, U., Loennechen, J., Currie, S., Smith, G., and Ellingsen, O. (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54(1), pp. 162-174. (doi:10.1016/S0008-6363(01)00565-X)

Smith, G.L., and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534(1), pp. 37-47. (doi:10.1111/j.1469-7793.2001.00037.x)

Most, P. et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98(24), pp. 13889-13894. (doi:10.1073/pnas.241393598)

Prestle, J., Janssen, P., Janssen, A., Zeitz, O., Lehnart, S., Bruce, L., Smith, G., and Hasenfuss, G. (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88(2), pp. 188-194.

Wisloff, U., Loennechen, J., Falck, G., Beisvag, V., Currie, S., Smith, G., and Ellingsen, O. (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50(3), pp. 495-508. (doi:10.1016/S0008-6363(01)00210-3)

MacFarlane, N.G., Miller, D.J., Smith, G.L., and Steele, D.S. (1994) Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research, 28(11), pp. 1647-1652. (doi:10.1093/cvr/28.11.1647) (PMID:7842458)

Conference Proceedings

Campbell, A. S., Burton, F. L., Baillie, G. L., and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

This list was generated on Fri Aug 28 16:05:12 2015 BST.