Prof Godfrey Smith

  • Professor of Cardiovascular Physiology (Institute of Cardiovascular and Medical Sciences)

telephone: 01413305963
email: Godfrey.Smith@glasgow.ac.uk

R415A Level 4
Institute of C&MS
West Medical Building
Glasgow G12 8QQ


Examination of the subcellular processes involved in excitation-contraction coupling of cardiac muscle using biophysical and biochemical techniques. Methodologies include fluorescence microscopy, electrophysiology and confocal imaging.

 

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Number of items: 92.

2014

Liu, Ting, Takimoto, Eiki, Dimaano, Veronica L., DeMazumder, Deeptankar, Kettlewell, Sarah, Smith, Godfrey, Sidor, Agnieszka, Abraham, Theodore P., and O'Rourke, Brian (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circulation Research, 115 (1). pp. 44-54. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.115.303062)

Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L, and Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica, 210 (4). pp. 854-864. ISSN 1748-1708 (doi:10.1111/apha.12238)

2013

Hoydal, M.A., Kaurstad, G., Rolim, N.P., Johnsen, A.B., Alves, M., Koch, L.G., Britton, S.L., Stolen, T.O., Smith, G.L., and Wisloff, U. (2013) High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of Applied Physiology, 115 (12). pp. 1788-1795. ISSN 8750-7587 (doi:10.1152/japplphysiol.00312.2013)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Sub-epicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6 (4). pp. 809-817. ISSN 1941-3149 (doi:10.1161/CIRCEP.113.000334)

Kettlewell, Sarah, Burton, Francis L., Smith, Godfrey L., and Workman, Antony J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation. Cardiovascular Research, 99 (1). pp. 215-224. ISSN 0008-6363 (doi:10.1093/cvr/cvt087)

Kettlewell, S., Burton, F.L., Smith, G.L., and Workman, A.J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99 (1). pp. 215-224. ISSN 0008-6363 (doi:10.1093/cvr/cvt087)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112 (3). pp. 424-431. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.300501)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, FL., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54 . pp. 53-64. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2012.10.017)

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100 (2). pp. 325-335. ISSN 0008-6363 (doi:10.1093/cvr/cvt187)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6 (4). pp. 809-817. ISSN 1941-3149 (doi:10.1161/CIRCEP.113.000334)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112 (3). pp. 424-431. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.300501)

2012

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97 (10). pp. 1131-1139. ISSN 0958-0670 (doi:10.1113/expphysiol.2012.065110)

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L., and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590 (17). pp. 4289-4305. ISSN 0022-3751 (doi:10.1113/jphysiol.2012.235986)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110 (12). pp. 1618-1627. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262337)

Kemi, Ole J., MacQuaide, Niall, Hoydal, Morten A., Ellingsen, Oyvind, Smith, Godfrey L., and Wisloff, Ulrik (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227 (1). pp. 20-26. ISSN 0021-9541 (doi:10.1002/jcp.22771)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165 (4b). pp. 1068-1083. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2011.01531.x)

2011

Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L., and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51 (5). pp. 627-631. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2011.08.003)

Koch, Lauren Gerard et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109 (10). pp. 1162-1172. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.253807)

Kemi, Ole J., Hoydal, Morten A., MacQuaide, Niall, Haram, Per M., Koch, Lauren G., Britton, Steven L., Ellingsen, Oyvind, Smith, Godfrey L., and Wisloff, Ulrik (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226 (9). pp. 2235-2243. ISSN 0021-9541 (doi:10.1002/jcp.22559)

Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108 (8). pp. 929-939. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.110.230698)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50 (3). pp. 510-512. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.11.019 )

Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1 (1). pp. 101-116. ISSN 2042-8898 (doi:10.1098/rsfs.2010.0005)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131 (2). pp. 204-220. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106 (6). pp. 1009-1022. ISSN 0300-8428 (doi:10.1007/s00395-011-0218-4)

McMurray, J.J.V., and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine . ISSN 0028-4793 (doi:10.1056/NEJMcibr1110758)

Rota, M., Biesmans, L., MacQuaide, N., Heinzel, F.R., Bito, V., Smith, G.L., and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6 (10). e25100. ISSN 1932-6203 (doi:10.1371/journal.pone.0025100)

Workman, A.J., Smith, G.L., and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131 (2). pp. 221-241. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.002)

2010

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105 (2). pp. 279-287. ISSN 0300-8428 (doi:10.1007/s00395-009-0057-8)

Craig, Margaret Anne, McBride, Martin W., Smith, Godfrey, George, Sarah, and Baker, Andrew (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48 (6). pp. 1121-1128. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.01.017)

Klauke, N., Smith, G., and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82 (2). pp. 585-592. ISSN 0003-2700 (doi:10.1021/ac901886j)

Cheng, W., Klauke, N., Smith, G., and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31 (8). pp. 1405-1413. ISSN 0173-0835

Eisner, D. A., George, C. H., Smith, G.L., Trafford, A. W., and Venetucci, L. A. (2010) How does CaMKII  phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences of the United States of America, 107 (31). E123-E123. ISSN 0027-8424 (doi:10.1073/pnas.1008809107)

MacQuaide, N., Ramay, H.R., Sobie, E.A., and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588 (23). pp. 4731-4742. ISSN 0022-3751 (doi:10.1113/jphysiol.2010.193375)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289 (8). H1812-H1822. ISSN 0363-6135 (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99 (10). pp. 255-261. ISSN 0091-679X (doi:10.1016/B978-0-12-374841-6.00009-8)

Zamparelli, Carlotta, MacQuaide, N., Colotti, Gianni, Verzili, Daniela, Seidler, Tim, Smith, G.L., and Chiancone, Emilia (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49 (1). pp. 132-141. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.03.003)

2009

Fowler, M., and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107 (6). pp. 1981-1984. ISSN 8750-7587 (doi:10.1152/japplphysiol.91168.2009)

Kettlewell, S., Seidler, T., and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflugers Archiv, 458 (4). pp. 653-660. ISSN 0031-6768 (doi:10.1007/s00424-009-0666-y)

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A., and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46 (6). pp. 891-901. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2009.02.016)

MacQuaide, N., Dempster, J., and Smith, G.L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized rabbit ventricular cardiomyocytes. Biophysical Journal, 96 (7). pp. 2744-2754. ISSN 0006-3495 (doi:10.1016/j.bpj.2008.12.3944)

Fowler, M.R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T., and Smith, G.L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv: European Journal of Physiology, 457 (5). pp. 1049-1060. ISSN 0031-6768 (doi:10.1007/s00424-008-0575-5)

Fowler, M.R., and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107 (6). p. 1988. ISSN 8750-7587 (doi:10.1152/japplphysiol.01088.2009)

Klauke, N., Smith, G.L., and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81 (15). pp. 6390-6398. ISSN 0003-2700 (doi:10.1021/ac9008429)

Masson, Rachel et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53 (4). pp. 694-700. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.108.122333)

Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105 (6). pp. 527-536. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.109.199810)

2008

Kemi, O.J., Ellingsen, O., Smith, G.L., and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13 . pp. 356-368. ISSN 1093-9946 (doi:10.2741/2685)

Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L., and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93 (12). pp. 1233-1238. ISSN 0958-0670 (doi:10.1113/expphysiol.2008.043497)

Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15 (2). pp. 145-148. ISSN 1741-8267 (doi:10.1097/HJR.0b013e3282efd4e0)

Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G., and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214 (2). pp. 316-321. ISSN 0021-9541 (doi:10.1002/jcp.21197)

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45 (1). pp. 1-10. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2008.03.024)

Schjerve, Inga E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115 (9). pp. 283-293. ISSN 0143-5221 (doi:10.1042/CS20070332)

2007

Chilton, L., Giles, W.R., and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583 (1). pp. 225-236. ISSN 0022-3751 (doi:10.1113/jphysiol.2007.135038)

Caldwell, J, Burton, FL, Smith, GL, and Cobbe, SM (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18 (8). pp. 854-861. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2007.00867.x)

Hoydal, MA, Wisloff, U, Kemi, OJ, Britton, SL, Koch, LG, Smith, GL, and Ellingsen, O (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14 (2). pp. 319-325. ISSN 1741-8267

Kemi, OJ, Ellingsen, O, Ceci, M, Grimaldi, S, Smith, GL, Condorelli, G, and Wisloff, U (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43 (3). pp. 354-361. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2007.06.013)

Loughrey, CM, Otani, N, Seidler, T, Craig, MA, Matsuda, R, Kaneko, N, and Smith, GL (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76 (2). pp. 236-246. ISSN 0008-6363 (doi:10.1016/j.cardiores.2007.06.014)

MacQuaide, N, Dempster, J, and Smith, GL (2007) Measurement and Modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93 (7). pp. 2581-2595. ISSN 0006-3495 (doi:10.1529/biophysj.106.102293)

Schillinger, W et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116 (1). pp. 57-66. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.106.666008)

Seidler, T, Loughrey, CM, Zibrova, D, Kettlewell, S, Teucher, N, Kogler, H, Hasenfuss, G, and Smith, GL (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101 (10). pp. 1020-1029. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.107.154609)

Smith, G (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92 (6). pp. 973-986. ISSN 0958-0670 (doi:10.1113/expphysiol.2007.034314)

Volkers, M et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41 (2). pp. 135-143. ISSN 0143-4160 (doi:10.1016/j.ceca.2006.06.001)

Walker, NL, Burton, FL, Kettlewell, S, Smith, GL, and Cobbe, SM (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18 (8). pp. 862-868. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2007.00858.x)

Wisloff, U et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115 (24). pp. 3086-3094. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.106.675041)

2006

Colotti, G, Zamparelli, C, Verzili, D, Mella, M, Loughrey, CM, Smith, GL, and Chiancone, E (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45 (41). pp. 12519-12529. ISSN 0006-2960 (doi:10.1021/bi060416a)

Kemi, OJ, Arbo, I, Hoydal, MA, Loennechen, JP, Wisloff, U, Smith, GL, and Ellingsen, O (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188 (3-4). pp. 185-193. ISSN 1748-1708 (doi:10.1111/j.1748-1716.2006.01621.x)

Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S., and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17 (s1). S57-S63. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2006.00384.x)

2005

Currie, S, Quinn, FR, Sayeed, RA, Duncan, AM, Kettlewell, S, and Smith, GL (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39 (2). pp. 309-317. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2005.04.005)

Kettlewell, S, Most, P, Currie, S, Koch, WJ, and Smith, GL (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39 (6). pp. 900-910. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2005.06.018)

Kohl, P, Camelliti, P, Burton, FL, and Smith, GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38 (4). pp. 45-50. ISSN 0022-0736 (doi:10.1016/j.jelectrocard.2005.06.096)

Miller, SLW, Currie, S, Loughrey, CM, Kettlewell, S, Seidler, T, Reynolds, DF, Hasenfuss, G, and Smith, GL (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67 (4). pp. 667-677. ISSN 0008-6363 (doi:10.1016/j.cardiores.2005.04.023)

2004

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556 (3). pp. 919-934. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287 (3). H1149-H1159. ISSN 0363-6135 (doi:10.1152/ajpheart.00060.2004)

Currie, S, Loughrey, CM, Craig, MA, and Smith, GL (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377 (2). pp. 357-366. ISSN 0264-6021 (doi:10.1042/BJ200310431)

Kettlewell, S, Walker, NL, Cobbe, SM, Burton, FL, and Smith, GL (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89 (2). pp. 163-172. ISSN 0958-0670 (doi:10.1113/expphysiol.2003.026732)

MacEachern, KE, Smith, GL, and Nolan, AM (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31 (4). pp. 239-249. ISSN 1467-2987 (doi:10.1111/j.1467-2995.2004.00176.x)

Teucher, N et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110 (23). pp. 3553-3559. ISSN 0009-7322 (doi:10.1161/01.CIR.0000145161.48545.B3)

Wokosin, DL, Loughrey, CM, and Smith, GL (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86 (3). pp. 1726-1738. ISSN 0006-3495 (doi:10.1016/S0006-3495(04)74241-1 )

2003

Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M., and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553 (1). pp. 229-242. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.050716)

McConnell, G, Smith, GL, Girkin, JM, Gurney, AM, and Ferguson, AI (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28 (19). pp. 1742-1744. ISSN 0146-9592 (doi:10.1364/OL.28.001742)

Most, P et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278 (29). pp. 26356-26364. ISSN 0021-9258 (doi:10.1074/jbc.M303338200)

Prestle, J, Quinn, FR, and Smith, GL (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10 (11). pp. 967-981. ISSN 0929-8673

Seidler, T et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93 (2). pp. 132-139. ISSN 0009-7330 (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13 (12). pp. 3535-3560. ISSN 0218-1274 (doi:10.1142/S0218127403008843)

2002

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543 (3). pp. 859-870. ISSN 0022-3751 (doi:10.1113/jphysiol.2002.021519)

Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L., and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74 (4). pp. 908-914. ISSN 0003-2700 (doi:10.1021/ac010941+)

Neary, P., Duncan, A.M., Cobbe, S.M., and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv: European Journal of Physiology, 444 (3). pp. 360-371. ISSN 0031-6768 (doi:10.1007/s00424-002-0794-0)

Ng, G.A., Hicks, M.N., Cobbe, S.M., and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv: European Journal of Physiology, 444 (4). pp. 513-522. ISSN 0031-6768 (doi:10.1007/s00424-002-0848-3)

Wisloff, U, Loennechen, JP, Currie, S, Smith, GL, and Ellingsen, O (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54 (1). pp. 162-174. ISSN 0008-6363 (doi:10.1016/S0008-6363(01)00565-X)

2001

Smith, G.L., and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534 (1). pp. 37-47. ISSN 0022-3751 (doi:10.1111/j.1469-7793.2001.00037.x)

Most, P et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98 (24). pp. 13889-13894. ISSN 0027-8424 (doi:10.1073/pnas.241393598)

Prestle, J, Janssen, PML, Janssen, AP, Zeitz, O, Lehnart, SE, Bruce, L, Smith, GL, and Hasenfuss, G (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88 (2). pp. 188-194. ISSN 0009-7330

Wisloff, U, Loennechen, JP, Falck, G, Beisvag, V, Currie, S, Smith, G, and Ellingsen, O (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50 (3). pp. 495-508. (doi:10.1016/S0008-6363(01)00210-3)

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Article

Liu, Ting, Takimoto, Eiki, Dimaano, Veronica L., DeMazumder, Deeptankar, Kettlewell, Sarah, Smith, Godfrey, Sidor, Agnieszka, Abraham, Theodore P., and O'Rourke, Brian (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circulation Research, 115 (1). pp. 44-54. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.115.303062)

Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L, and Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica, 210 (4). pp. 854-864. ISSN 1748-1708 (doi:10.1111/apha.12238)

Hoydal, M.A., Kaurstad, G., Rolim, N.P., Johnsen, A.B., Alves, M., Koch, L.G., Britton, S.L., Stolen, T.O., Smith, G.L., and Wisloff, U. (2013) High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of Applied Physiology, 115 (12). pp. 1788-1795. ISSN 8750-7587 (doi:10.1152/japplphysiol.00312.2013)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Sub-epicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6 (4). pp. 809-817. ISSN 1941-3149 (doi:10.1161/CIRCEP.113.000334)

Kettlewell, Sarah, Burton, Francis L., Smith, Godfrey L., and Workman, Antony J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation. Cardiovascular Research, 99 (1). pp. 215-224. ISSN 0008-6363 (doi:10.1093/cvr/cvt087)

Kettlewell, S., Burton, F.L., Smith, G.L., and Workman, A.J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99 (1). pp. 215-224. ISSN 0008-6363 (doi:10.1093/cvr/cvt087)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112 (3). pp. 424-431. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.300501)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, FL., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54 . pp. 53-64. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2012.10.017)

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100 (2). pp. 325-335. ISSN 0008-6363 (doi:10.1093/cvr/cvt187)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6 (4). pp. 809-817. ISSN 1941-3149 (doi:10.1161/CIRCEP.113.000334)

Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L., and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112 (3). pp. 424-431. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.300501)

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97 (10). pp. 1131-1139. ISSN 0958-0670 (doi:10.1113/expphysiol.2012.065110)

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L., and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590 (17). pp. 4289-4305. ISSN 0022-3751 (doi:10.1113/jphysiol.2012.235986)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110 (12). pp. 1618-1627. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262337)

Kemi, Ole J., MacQuaide, Niall, Hoydal, Morten A., Ellingsen, Oyvind, Smith, Godfrey L., and Wisloff, Ulrik (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227 (1). pp. 20-26. ISSN 0021-9541 (doi:10.1002/jcp.22771)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165 (4b). pp. 1068-1083. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2011.01531.x)

Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L., and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51 (5). pp. 627-631. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2011.08.003)

Koch, Lauren Gerard et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109 (10). pp. 1162-1172. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.253807)

Kemi, Ole J., Hoydal, Morten A., MacQuaide, Niall, Haram, Per M., Koch, Lauren G., Britton, Steven L., Ellingsen, Oyvind, Smith, Godfrey L., and Wisloff, Ulrik (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226 (9). pp. 2235-2243. ISSN 0021-9541 (doi:10.1002/jcp.22559)

Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108 (8). pp. 929-939. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.110.230698)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50 (3). pp. 510-512. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.11.019 )

Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1 (1). pp. 101-116. ISSN 2042-8898 (doi:10.1098/rsfs.2010.0005)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131 (2). pp. 204-220. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106 (6). pp. 1009-1022. ISSN 0300-8428 (doi:10.1007/s00395-011-0218-4)

McMurray, J.J.V., and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine . ISSN 0028-4793 (doi:10.1056/NEJMcibr1110758)

Rota, M., Biesmans, L., MacQuaide, N., Heinzel, F.R., Bito, V., Smith, G.L., and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6 (10). e25100. ISSN 1932-6203 (doi:10.1371/journal.pone.0025100)

Workman, A.J., Smith, G.L., and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131 (2). pp. 221-241. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.002)

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105 (2). pp. 279-287. ISSN 0300-8428 (doi:10.1007/s00395-009-0057-8)

Craig, Margaret Anne, McBride, Martin W., Smith, Godfrey, George, Sarah, and Baker, Andrew (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48 (6). pp. 1121-1128. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.01.017)

Klauke, N., Smith, G., and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82 (2). pp. 585-592. ISSN 0003-2700 (doi:10.1021/ac901886j)

Cheng, W., Klauke, N., Smith, G., and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31 (8). pp. 1405-1413. ISSN 0173-0835

Eisner, D. A., George, C. H., Smith, G.L., Trafford, A. W., and Venetucci, L. A. (2010) How does CaMKII  phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences of the United States of America, 107 (31). E123-E123. ISSN 0027-8424 (doi:10.1073/pnas.1008809107)

MacQuaide, N., Ramay, H.R., Sobie, E.A., and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588 (23). pp. 4731-4742. ISSN 0022-3751 (doi:10.1113/jphysiol.2010.193375)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289 (8). H1812-H1822. ISSN 0363-6135 (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99 (10). pp. 255-261. ISSN 0091-679X (doi:10.1016/B978-0-12-374841-6.00009-8)

Zamparelli, Carlotta, MacQuaide, N., Colotti, Gianni, Verzili, Daniela, Seidler, Tim, Smith, G.L., and Chiancone, Emilia (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49 (1). pp. 132-141. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2010.03.003)

Fowler, M., and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107 (6). pp. 1981-1984. ISSN 8750-7587 (doi:10.1152/japplphysiol.91168.2009)

Kettlewell, S., Seidler, T., and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflugers Archiv, 458 (4). pp. 653-660. ISSN 0031-6768 (doi:10.1007/s00424-009-0666-y)

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A., and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46 (6). pp. 891-901. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2009.02.016)

MacQuaide, N., Dempster, J., and Smith, G.L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized rabbit ventricular cardiomyocytes. Biophysical Journal, 96 (7). pp. 2744-2754. ISSN 0006-3495 (doi:10.1016/j.bpj.2008.12.3944)

Fowler, M.R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T., and Smith, G.L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv: European Journal of Physiology, 457 (5). pp. 1049-1060. ISSN 0031-6768 (doi:10.1007/s00424-008-0575-5)

Fowler, M.R., and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107 (6). p. 1988. ISSN 8750-7587 (doi:10.1152/japplphysiol.01088.2009)

Klauke, N., Smith, G.L., and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81 (15). pp. 6390-6398. ISSN 0003-2700 (doi:10.1021/ac9008429)

Masson, Rachel et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53 (4). pp. 694-700. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.108.122333)

Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105 (6). pp. 527-536. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.109.199810)

Kemi, O.J., Ellingsen, O., Smith, G.L., and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13 . pp. 356-368. ISSN 1093-9946 (doi:10.2741/2685)

Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L., and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93 (12). pp. 1233-1238. ISSN 0958-0670 (doi:10.1113/expphysiol.2008.043497)

Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15 (2). pp. 145-148. ISSN 1741-8267 (doi:10.1097/HJR.0b013e3282efd4e0)

Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G., and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214 (2). pp. 316-321. ISSN 0021-9541 (doi:10.1002/jcp.21197)

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45 (1). pp. 1-10. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2008.03.024)

Schjerve, Inga E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115 (9). pp. 283-293. ISSN 0143-5221 (doi:10.1042/CS20070332)

Chilton, L., Giles, W.R., and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583 (1). pp. 225-236. ISSN 0022-3751 (doi:10.1113/jphysiol.2007.135038)

Caldwell, J, Burton, FL, Smith, GL, and Cobbe, SM (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18 (8). pp. 854-861. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2007.00867.x)

Hoydal, MA, Wisloff, U, Kemi, OJ, Britton, SL, Koch, LG, Smith, GL, and Ellingsen, O (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14 (2). pp. 319-325. ISSN 1741-8267

Kemi, OJ, Ellingsen, O, Ceci, M, Grimaldi, S, Smith, GL, Condorelli, G, and Wisloff, U (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43 (3). pp. 354-361. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2007.06.013)

Loughrey, CM, Otani, N, Seidler, T, Craig, MA, Matsuda, R, Kaneko, N, and Smith, GL (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76 (2). pp. 236-246. ISSN 0008-6363 (doi:10.1016/j.cardiores.2007.06.014)

MacQuaide, N, Dempster, J, and Smith, GL (2007) Measurement and Modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93 (7). pp. 2581-2595. ISSN 0006-3495 (doi:10.1529/biophysj.106.102293)

Schillinger, W et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116 (1). pp. 57-66. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.106.666008)

Seidler, T, Loughrey, CM, Zibrova, D, Kettlewell, S, Teucher, N, Kogler, H, Hasenfuss, G, and Smith, GL (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101 (10). pp. 1020-1029. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.107.154609)

Smith, G (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92 (6). pp. 973-986. ISSN 0958-0670 (doi:10.1113/expphysiol.2007.034314)

Volkers, M et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41 (2). pp. 135-143. ISSN 0143-4160 (doi:10.1016/j.ceca.2006.06.001)

Walker, NL, Burton, FL, Kettlewell, S, Smith, GL, and Cobbe, SM (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18 (8). pp. 862-868. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2007.00858.x)

Wisloff, U et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115 (24). pp. 3086-3094. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.106.675041)

Colotti, G, Zamparelli, C, Verzili, D, Mella, M, Loughrey, CM, Smith, GL, and Chiancone, E (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45 (41). pp. 12519-12529. ISSN 0006-2960 (doi:10.1021/bi060416a)

Kemi, OJ, Arbo, I, Hoydal, MA, Loennechen, JP, Wisloff, U, Smith, GL, and Ellingsen, O (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188 (3-4). pp. 185-193. ISSN 1748-1708 (doi:10.1111/j.1748-1716.2006.01621.x)

Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S., and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17 (s1). S57-S63. ISSN 1540-8167 (doi:10.1111/j.1540-8167.2006.00384.x)

Currie, S, Quinn, FR, Sayeed, RA, Duncan, AM, Kettlewell, S, and Smith, GL (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39 (2). pp. 309-317. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2005.04.005)

Kettlewell, S, Most, P, Currie, S, Koch, WJ, and Smith, GL (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39 (6). pp. 900-910. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2005.06.018)

Kohl, P, Camelliti, P, Burton, FL, and Smith, GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38 (4). pp. 45-50. ISSN 0022-0736 (doi:10.1016/j.jelectrocard.2005.06.096)

Miller, SLW, Currie, S, Loughrey, CM, Kettlewell, S, Seidler, T, Reynolds, DF, Hasenfuss, G, and Smith, GL (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67 (4). pp. 667-677. ISSN 0008-6363 (doi:10.1016/j.cardiores.2005.04.023)

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556 (3). pp. 919-934. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287 (3). H1149-H1159. ISSN 0363-6135 (doi:10.1152/ajpheart.00060.2004)

Currie, S, Loughrey, CM, Craig, MA, and Smith, GL (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377 (2). pp. 357-366. ISSN 0264-6021 (doi:10.1042/BJ200310431)

Kettlewell, S, Walker, NL, Cobbe, SM, Burton, FL, and Smith, GL (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89 (2). pp. 163-172. ISSN 0958-0670 (doi:10.1113/expphysiol.2003.026732)

MacEachern, KE, Smith, GL, and Nolan, AM (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31 (4). pp. 239-249. ISSN 1467-2987 (doi:10.1111/j.1467-2995.2004.00176.x)

Teucher, N et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110 (23). pp. 3553-3559. ISSN 0009-7322 (doi:10.1161/01.CIR.0000145161.48545.B3)

Wokosin, DL, Loughrey, CM, and Smith, GL (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86 (3). pp. 1726-1738. ISSN 0006-3495 (doi:10.1016/S0006-3495(04)74241-1 )

Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M., and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553 (1). pp. 229-242. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.050716)

McConnell, G, Smith, GL, Girkin, JM, Gurney, AM, and Ferguson, AI (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28 (19). pp. 1742-1744. ISSN 0146-9592 (doi:10.1364/OL.28.001742)

Most, P et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278 (29). pp. 26356-26364. ISSN 0021-9258 (doi:10.1074/jbc.M303338200)

Prestle, J, Quinn, FR, and Smith, GL (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10 (11). pp. 967-981. ISSN 0929-8673

Seidler, T et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93 (2). pp. 132-139. ISSN 0009-7330 (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13 (12). pp. 3535-3560. ISSN 0218-1274 (doi:10.1142/S0218127403008843)

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543 (3). pp. 859-870. ISSN 0022-3751 (doi:10.1113/jphysiol.2002.021519)

Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L., and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74 (4). pp. 908-914. ISSN 0003-2700 (doi:10.1021/ac010941+)

Neary, P., Duncan, A.M., Cobbe, S.M., and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv: European Journal of Physiology, 444 (3). pp. 360-371. ISSN 0031-6768 (doi:10.1007/s00424-002-0794-0)

Ng, G.A., Hicks, M.N., Cobbe, S.M., and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv: European Journal of Physiology, 444 (4). pp. 513-522. ISSN 0031-6768 (doi:10.1007/s00424-002-0848-3)

Wisloff, U, Loennechen, JP, Currie, S, Smith, GL, and Ellingsen, O (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54 (1). pp. 162-174. ISSN 0008-6363 (doi:10.1016/S0008-6363(01)00565-X)

Smith, G.L., and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534 (1). pp. 37-47. ISSN 0022-3751 (doi:10.1111/j.1469-7793.2001.00037.x)

Most, P et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98 (24). pp. 13889-13894. ISSN 0027-8424 (doi:10.1073/pnas.241393598)

Prestle, J, Janssen, PML, Janssen, AP, Zeitz, O, Lehnart, SE, Bruce, L, Smith, GL, and Hasenfuss, G (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88 (2). pp. 188-194. ISSN 0009-7330

Wisloff, U, Loennechen, JP, Falck, G, Beisvag, V, Currie, S, Smith, G, and Ellingsen, O (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50 (3). pp. 495-508. (doi:10.1016/S0008-6363(01)00210-3)

This list was generated on Thu Jul 24 15:40:10 2014 BST.

Editorial Board

  • 1999 - ongoing: Experimental Physiology - Journal Editor

Grant Advisory Board

  • 2001 - 2005: British Heart Foundation - Project Grants Committee

Invited International Presentations

  • 2004: The International Society for Cardiovascular Research Symposium - Heart failure, disorders of Ca handling
  • 2004: Trondheim, Norway - "Cellular Biology of Exercise Training in Cardiovascular Disease"
  • 2004: The British Society for Cardiovascular Research meeting - Integrative cardiovascular pathophysiology in gene-modified models.
  • 2004: Lundsbrunn Spa, Sweden - Scandinavian Physiological Society Meeting on: Transport and membrane trafficking in cells
  • 2002: Lillehamer, Norway - Annual meeting of the Norwegian Cardiology Society
  • 2002: London, England - The British Society for Cardiovascular Research meeting on: Ion Channels and Transporters in Cardiovascular cell growth
  • 2002: London, England - The Physiological Society on: Cardiac electrophysiology, heterogeneity in the heart
  • 2002: Cavalese, Italy - 12th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease
  • 2002: London, England - The Physiological Society Symposium on the Athletes Heart

Prizes, Awards and Distinctions

  • 2005: Physiological Society, G.L. Brown Prize Lecture

Professional Learned Society

  • 2003 - ongoing: British Cardiac Society - Member
  • 1995 - ongoing: British Society for Cardiovascular Research - Member
  • 1993 - ongoing: Biophysical Society - USA - Member
  • 1986 - ongoing: Physiological Society - Grants Subcommittee 1999-2005, Dale and Rushton Fund Co-treasurer 1999-2005, Further Education Subcommittee 1999-2002, Memberships Committee (Chair) 2002-05, Council Member 1998-2004

Research Fellowship

  • 1988 - 1991: British Heart Foundation Fellowship