Professor Godfrey Smith

  • Professor of Cardiovascular Physiology (Institute of Cardiovascular and Medical Sciences)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413305963
email: Godfrey.Smith@glasgow.ac.uk

Research interests

Examination of the subcellular processes involved in excitation-contraction coupling of cardiac muscle using biophysical and biochemical techniques. Methodologies include fluorescence microscopy, electrophysiology and confocal imaging.

 

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Monitoring contractlitiy of bio-realistic human cardiac tissue in-vitro ref CRACK IT Challenges 35587-259131
    National Centre for Replacement,Refinement and Reduction of
    2014 - 2014
     
  • Human atrial action potential alternans and afterdepolarisations: electrophysiological and calcium-cycling mechanisms and effects of myocardial disease
    British Heart Foundation
    2013 - 2016
     
  • The role of RyR cluster morphology in Ca2+ homeostasis
    British Heart Foundation
    2013 - 2017
     
  • Investigating the therapeutic potential of cathepsin-L inhibition to limit ischaemia-reperfusion injury in the heart
    Scottish Executive Health Department
    2013 - 2015
     
  • IAA-EPSRC: Upgrade of cellOPTIQ function to allow simultaneous multiple fluorescence measurements
    Engineering & Physical Sciences Research Council
    2012 - 2015
     
  • Electrophysiology Chip on a Microfluidic Platform
    BBSRC
    2011 - 2014
     
  • Cardiac CaMK in heart failure and exercise training
    British Heart Foundation
    2010 - 2013
     
  • KTA-EPSRC:Design and production of demo prototype of CellOPTIQ
    Engineering & Physical Sciences Research Council
    2009 - 2012
     
  • Production of cardiomyocytes from human embryonic stem cells
    Stem Cells for Safer Medicines
    2009 - 2010
     
  • EUTrigTreat - Indentification and therapeutic targeting of common arrhythmia trigger mechanisms
    European Commission
    2009 - 2014
     
  • Atrial remodelling of calcium handling and electrophysiology in heart failure.
    British Heart Foundation
    2009 - 2013
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Hypothermia - Competence programme in diving
    The Norwegian University of Science and Technology
    2008 - 2008
     
  • Scottish Universities Life Sciences Alliance (SULSA)- Cell Biology
    Scottish Funding Council
    2008 - 2015
     
  • Does ACE2 have a protective role in the heart? Systematic analysis of ACE2 in a disease model
    British Heart Foundation
    2007 - 2010
     
  • Targeted disruption of sarcoplasmic reticulum mediated Ca2+ handling and diastolic dysfunction: A comaprison between isolated cardiomyocytes and the whole heart.
    Heart Research UK
    2007 - 2009
     
  • Heartwave II Microvolt T-wave alternans system
    The Norwegian University of Science and Technology
    2007 - 2007
     
  • The effect of Ca2+ microdomains on Ca2+ dependent processes in cardiac ventricular myocytes
    British Heart Foundation
    2007 - 2010
     
  • Investigating the role of intracellular calcium in the left ventricular diastolic dysfunction
    Medical Research Scotland
    2006 - 2008
     
  • The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
    British Heart Foundation
    2006 - 2009
     
  • Unravelling the effect of cadherin dysregulation in the heart
    Wellcome Trust
    2006 - 2007
     
  • Cellular Basis of Arrhythmias:The Inter-Relationship between Ca2+ Transients and Ca2+ Waves in Cardiac Muscle
    British Heart Foundation
    2006 - 2009
     
  • Effect of Acidosis on the cardiac atrio-ventricular node
    British Heart Foundation
    2005 - 2006
     
  • Investigation of calcium signalling in sarcoplasmic riticulum of cardiac myocytes using a novel targeted reporter
    BBSRC
    2005 - 2008
     
  • Electrophysiology of ventricular myofybroblasts within myocardial infarction scars of rabbit hearts
    British Heart Foundation
    2005 - 2005
     
  • Atrioventricular nodal function in a rabbit model of chronic heart failure
    British Heart Foundation
    2005 - 2007
     
  • High Fidelity Phenotyping combined with genomics, proteomics and metabonomics close to the patient
    British Heart Foundation
    2004 - 2008
     
  • A longitudinal study of myocardial remodelling following infarction in the rabbit heart
    British Heart Foundation
    2004 - 2009
     
  • A study of the subcellular actions of sorcin in ventricular cardiac muscle
    British Heart Foundation
    2004 - 2007
     
  • Factors affecting the success of defibrillation in ischaemia (Dr Jane Caldwell)
    British Heart Foundation
    2004 - 2007
     
  • A study of the mechanisms and dynamics of action potential adaptation to increase in heart rate
    British Heart Foundation
    2002 - 2005
     
  • The role of FK binding proteins in the modulation of excitation-contraction coupling in cardiac muscle
    Wellcome Trust
    2002 - 2005
     

Additional information

Editorial Board

  • 1999 - ongoing: Experimental Physiology - Journal Editor

Grant Advisory Board

  • 2001 - 2005: British Heart Foundation - Project Grants Committee

Invited International Presentations

  • 2004: The International Society for Cardiovascular Research Symposium - Heart failure, disorders of Ca handling
  • 2004: Trondheim, Norway - "Cellular Biology of Exercise Training in Cardiovascular Disease"
  • 2004: The British Society for Cardiovascular Research meeting - Integrative cardiovascular pathophysiology in gene-modified models.
  • 2004: Lundsbrunn Spa, Sweden - Scandinavian Physiological Society Meeting on: Transport and membrane trafficking in cells
  • 2002: Lillehamer, Norway - Annual meeting of the Norwegian Cardiology Society
  • 2002: London, England - The British Society for Cardiovascular Research meeting on: Ion Channels and Transporters in Cardiovascular cell growth
  • 2002: London, England - The Physiological Society on: Cardiac electrophysiology, heterogeneity in the heart
  • 2002: Cavalese, Italy - 12th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease
  • 2002: London, England - The Physiological Society Symposium on the Athletes Heart

Prizes, Awards and Distinctions

  • 2005: Physiological Society, G.L. Brown Prize Lecture

Professional Learned Society

  • 2003 - ongoing: British Cardiac Society - Member
  • 1995 - ongoing: British Society for Cardiovascular Research - Member
  • 1993 - ongoing: Biophysical Society - USA - Member
  • 1986 - ongoing: Physiological Society - Grants Subcommittee 1999-2005, Dale and Rushton Fund Co-treasurer 1999-2005, Further Education Subcommittee 1999-2002, Memberships Committee (Chair) 2002-05, Council Member 1998-2004

Research Fellowship

  • 1988 - 1991: British Heart Foundation Fellowship