Professor Eleanor Davies

  • Professor of Molecular Endocrinology (Institute of Cardiovascular and Medical Sciences)

telephone: 01413302376
email: Eleanor.Davies@glasgow.ac.uk

Research interests

I graduated from Glasgow University with a BSc (Hons) Biochemistry and then from Edinburgh University with a PhD. After a 3-year INSERM Fellowship in Paris, I returned to Glasgow in 1994.

My main research interest is the role of the steroid hormones aldosterone and cortisol in cardiovascular disease. These hormones are made in the adrenal gland by the enzymes aldosterone synthase and 11b-hydroxylase and are encoded by the CYP11B2 and CYP11B1 genes respectively.

Working with Professor John Connell, our studies have been funded by successive Programme Grants from the MRC in addition to Project Grants from the British Heart Foundation and the Wellcome Trust. We have adopted a translational research approach integrating basic molecular biology, in vitro cell biology and human investigations, ranging from small focussed studies in normal and hypertensive subjects to large-scale population studies. The availability of many of these large, unique populations has been achieved through several successful collaborations with a number of complementary centres.

Using these tools, we have made a number of key observations. These include the identification of the heritable nature of corticosteroid synthesis, the identification of several novel polymorphic variants in CYP11B2, association of this variation with increased aldosterone production and hypertension. There is also evidence of inefficient 11b-hydroxylation which appears to be due to tight linkage dysequilibrium of the variants in CYP11B2 with novel causal variants in the regulatory region of the CYP11B1 gene which alter gene transcription. These studies represent a significant advance in our understanding of adrenal steroid synthesis regulation and the contribution of steroids to cardiovascular dysfunction.

Research Collaborations:
Professor Bill Rainey, Georgia, USA
Dr Rebecca Reynolds, Edinburgh, UK
Dr Chris Kenyon, Edinburgh, UK
Prof Bernard Keavney, Newcastle, UK
Prof Celso Gomez-Sanchez, Mississippi, USA

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Understanding the genetic regulation of adrenal steroid hormones in cardiovascular disease â?? Developing a stratified approach to cardiovascular care
    Scottish Executive Health Department
    2014 - 2016
     
  • Conference Grant
    Society for Endocrinology/Clinical Endocrinology Trust
    2013 - 2015
     
  • Travel Funding
    Society for Endocrinology/Clinical Endocrinology Trust
    2012 - 2013
     
  • Analysis of the Adrenodoxin and Adrenodoxin Reductase Genes in Cardiovascular Diseases
    Medical Research Foundation
    2011 - 2012
     
  • Conference Grant
    Society for Endocrinology/Clinical Endocrinology Trust
    2010 - 2011
     
  • Regulation of aldosterone synthase (CYP11B2) and 11b-Hydroxylase gene expression by novel micro RNAs
    British Heart Foundation
    2010 - 2013
     
  • Society for Endocrinology - Travel Grant
    Society for Endocrinology/Clinical Endocrinology Trust
    2010 - 2011
     
  • Variation in promoter function in CYP11B2 and regulation of aldosterone secretion in cardiovascular disease
    MRC
    2007 - 2010
     
  • Regulation of aldosterone and cortisol synthesis in hypertension and cardiovascular disease
    MRC
    2005 - 2011
     
  • Functional analysis of polymorphisms/mutations in steroidogenic genes and their implications for human cardiovascular homeostasis
    British Heart Foundation
    2005 - 2007
     
  • Quantification of 11 beta-hydroxylase (CYP11B1) gene expression in adipose tissue from normal and obese human subjects
    Tenovus-Scotland
    2004 - 2005
     
  • Expression of 11 beta-hydroxylase and aldosterone synthase in the human central nervous system
    North Glasgow University Hospitals NHS Trust
    2003 - 2005
     
  • The Role of Corticosteroids in Cardiovascular Regulation - Studies of the Molecular Basis for Altered Steroid Synthesis
    MRC
    2000 - 2005
     

Additional information

Editorial Board

  • 2009 - ongoing: Endocrinology USA - Editorial Board Member
  • 2003 - 2007: Endocrinology - Member

Grant Advisory Board

  • - ongoing: Medical Research Council - Grant reviewer
  • - ongoing: Wellcome Trust - Grant reviewer
  • - ongoing: British Heart Foundation - Grant reviewer
  • - ongoing: BBSRC - Grant reviewer
  • - ongoing: Royal Society - Grant reviewer

Professional Learned Society

  • 2012 - 2012: Society for Endocrinology - Programme Co-ordinator for BES 2012
  • 2011 - 2015: Chief Scientist Office - Member of Experimental and Translational Medical Research Committee
  • 2010 - 2014: Society for Endocrinology - Member of Programme Committee
  • 2009 - 2010: International Aldosterone Conference (USA) - Chairman
  • 2008 - 2009: International Aldosterone Conference (USA) - Co-Chairman
  • 2005 - 2008: Society for Endocrinology - Member of Science Committee
  • 2005 - 2009: Society for Endocrinology - Member of Science Committee
  • 2005 - ongoing: Faculty of Medicine 1000 - Faculty Member of Diabetes and Endocrinology

Publications

List by: Type | Date

Jump to: 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
Number of items: 39.

2013

Robertson, S., MacKenzie, S. M., Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M., and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62 (3). pp. 572-578. ISSN 0194-911X (doi:10.1161/​HYPERTENSIONAHA.113.01102)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61 (1). pp. 232-239. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.112.200741)

2012

Freel, E. M., Mark, P. B. , Weir, R. A.P., McQuarrie, E. P., Allan, K., Dargie, H. J., McClure, J. D., Jardine, A. G., Davies, E., and Connell, J. M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5 (6). pp. 740-747. ISSN 1941-9651 (doi:10.1161/CIRCIMAGING.112.974576)

McManus, F., Sands, W., Diver, L., MacKenzie, S. M., Fraser, R., Davies, E., and Connell, J. M. (2012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circulation Research, 111 (2). pp. 212-219. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262931)

MacKenzie, S. M., Connell, J. M.C., and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350 (2). pp. 163-167. ISSN 0303-7207 (doi:10.1016/j.mce.2011.06.026)

2010

McNeilly, A. D. et al. (2010) Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. Journal of Hepatology, 52 (5). pp. 705-711. ISSN 0168-8278 (doi:10.1016/j.jhep.2009.10.037)

2009

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M., and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94 (11). pp. 4324-4333. ISSN 0021-972X (doi:10.1210/jc.2009-1406)

Reynolds, R. M., Walker, B. R. , Phillips, D. I., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E., and Connell, J. M. (2009) Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53 (6). pp. 932-936. ISSN 0194-911X (doi:10.1161/​HYPERTENSIONAHA.109.129320)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70 (3). pp. 363-371. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2008.03383.x)

Davies, E., Davies, E., Ainsworth, R., Aitken, C., Carman, W., and Kroes, A. (2009) Viral myocarditis. Journal of Clinical Virology, 45 (3). VII-VIX.

2008

Huda, S. S., MacKenzie, S. M., Sattar, N., Fraser, R., Connell, J. M. C., and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69 (6). pp. 848-854. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2008.03262.x )

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E., and Connell, J.M.C. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68 (5). pp. 700-706. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.03116.x )

Connell, J. M.C., MacKenzie, S. M., Freel, E. M., Fraser, R., and Davies, E. (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29 (2). pp. 133-154. ISSN 0163-769X (doi:10.1210/er.2007-0030 )

Ye, P., Kenyon, C. J., MacKenzie, S. M., Nichol, K., Seckl, J. R., Fraser, R., Connell, J. M.C., and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase(CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196 (2). pp. 305-311. ISSN 0022-0795 (doi:10.1677/JOE-07-0439)

MacKenzie, S. M., Dewar, D., Stewart, W., Fraser, R., Connell, J. M. C., and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196 (1). pp. 123-130. ISSN 0022-0795 (doi:10.1677/JOE-07-0427)

2007

Freel, E.M. et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67 (6). pp. 832-838. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.02971.x)

Freel, E.M., Bernhardt, M., Ingram, R., Wallace, A.M., Fraser, R., Davies, E., and Connell, J.M.C. (2007) Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy. Clinical Endocrinology, 66 (5). pp. 659-665. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.02791.x)

Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49 . pp. 113-119. (doi:10.1161/01.HYP.0000249904.93940.7a)

2006

Barr, M., MacKenzie, S., Wilkinson, D., Holloway, C., Friel, E., Miller, S., MacDonald, T., Fraser, R., Connell, J., and Davies, E. (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65 . pp. 816-825. (doi:10.1111/j.1365-2265.2006.02673.x)

Imrie, H. et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91 (12). pp. 5051-5056. ISSN 0021-972X (doi:10.1210/jc.2006-1481)

2005

Connell, J., and Davies, E. (2005) The new biology of aldosterone. Journal of Endocrinology, 186 . pp. 1-20. (doi:10.1677/joe.1.06017)

Imrie, H., Mayosi, B., Baker, M., Fraser, R., Davies, E., Ingram, M., Watkins, H., Farrall, M., Connell, J., and Keavney, B. (2005) Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Journal of Clinical Endocrinology and Metabolism, 90 . pp. 1072-1077. (doi:10.1210/jc.2004-0870)

2004

Freel, E., Shakerdi, L.A., Friel, E., Wallace, A.M., Davies, E., Fraser, R., and Connell, J.M.C. (2004) Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89 (9). pp. 4628-4633. ISSN 0021-972X (doi:10.1210/jc.2004-0379)

Freel, E.M., Shakerdi, L., Friel, E., Wallace, A.M., Davies, E., Fraser, R., and Connell, J.M.C. (2004) The origin of circulating 18-oxo and 18-hydroxycortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89 (9). pp. 4628-4633. ISSN 0021-972X (doi:10.1210/jc.2004-0379)

Kennon, B., Ingram, M., Friel, E., Anderson, N., MacKenzie, S., Davies, E., Shakerdi, L., Wallace, A., Fraser, R., and Connell, J. (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61 . pp. 174-181. (doi:10.1111/j.1365-2265.2004.02073.x)

2003

Connell, J., Fraser, R., MacKenzie, S., and Davies, E. (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41 . pp. 993-999. (doi:10.1161/01.HYP.0000064344.00173.44)

Davies, E., and Kenyon, C. (2003) CYP11B2 polymorphisms and cardiovascular risk factors. [Editorial]. Journal of Hypertension, 21 (7). pp. 1249-1253.

Davies, E., and MacKenzie, S. (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30 . pp. 437-445.

Ye, P., Kenyon, C., MacKenzie, S., Seckl, J., Fraser, R., Connell, J., and Davies, E. (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144 . pp. 3321-3328. (doi:10.1210/en.2003-0109)

2002

Draper, N. et al. (2002) Association Studies between Microsatellite Markers within the Gene Encoding Human 11{beta}-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio, and Glucocorticoid Metabolism. Journal of Clinical Endocrinology and Metabolism, 87 (11). pp. 4984-4990. ISSN 0021-972X (doi:10.1210/jc.2001-011375)

Lim, P., MacDonald, T., Holloway, C., Friel, E., Anderson, N., Dow, E., Jung, R., Davies, E., Fraser, R., and Connell, J. (2002) Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. Journal of Clinical Endocrinology and Metabolism, 87 (9). pp. 4398-4402.

MacKenzie, S.M., Fraser, R., Connell, J.M.C., and Davies, E. (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-Angiotensin-Aldosterone System, 3 . pp. 214-221. ISSN 1470-3203

MacKenzie, S., Lai, M., Clark, C., Fraser, R., Gomez-Sanchez, C., Seckl, J., Connell, J., and Davies, E. (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29 (3). pp. 319-325. (doi:10.1677/jme.0.0290319)

2001

Connell, J.M.C., Fraser, R., and Davies, E. (2001) Disorders of mineralocorticoid synthesis. Best Practice and Research: Clinical Endocrinology and Metabolism, 15 . pp. 43-60. ISSN 1521-690X (doi:10.1053/beem.2000.0118)

Davies, E., Holloway, C., Ingram, M., Friel, E., Inglis, G., Swan, L., Hillis, W., Fraser, R., and Connell, J. (2001) An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects. Clinical Endocrinology, 54 . pp. 813-817.

Fisher, A., Friel, E., Bernhardt, R., Gomez-Sanchez, C., Connell, J., Fraser, R., and Davies, E. (2001) Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11 beta-hydroxylase. Journal of Clinical Endocrinology and Metabolism, 86 . pp. 4326-4329.

Inglis, G., Plouin, P., Friel, E., Davies, E., Fraser, R., and Connell, J. (2001) Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). Clinical Endocrinology, 54 . pp. 725-730.

2000

Clark, C.J., Davies, E., Anderson, N.H., Farmer, R., Friel, E.C., Fraser, R., and Connell, J.M.C. (2000) alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. Hypertension, 36 (6). pp. 990-994. ISSN 0194-911X

MacKenzie, S., Clark, C., Ingram, M., Lai, M., Seckl, J., Gomez-Sanchez, C., Fraser, R., Connell, J., and Davies, E. (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26 (4). pp. 531-535.

This list was generated on Fri Oct 31 07:51:49 2014 GMT.
Jump to: Article
Number of items: 39.

Article

Robertson, S., MacKenzie, S. M., Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M., and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62 (3). pp. 572-578. ISSN 0194-911X (doi:10.1161/​HYPERTENSIONAHA.113.01102)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61 (1). pp. 232-239. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.112.200741)

Freel, E. M., Mark, P. B. , Weir, R. A.P., McQuarrie, E. P., Allan, K., Dargie, H. J., McClure, J. D., Jardine, A. G., Davies, E., and Connell, J. M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5 (6). pp. 740-747. ISSN 1941-9651 (doi:10.1161/CIRCIMAGING.112.974576)

McManus, F., Sands, W., Diver, L., MacKenzie, S. M., Fraser, R., Davies, E., and Connell, J. M. (2012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circulation Research, 111 (2). pp. 212-219. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262931)

MacKenzie, S. M., Connell, J. M.C., and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350 (2). pp. 163-167. ISSN 0303-7207 (doi:10.1016/j.mce.2011.06.026)

McNeilly, A. D. et al. (2010) Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. Journal of Hepatology, 52 (5). pp. 705-711. ISSN 0168-8278 (doi:10.1016/j.jhep.2009.10.037)

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M., and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94 (11). pp. 4324-4333. ISSN 0021-972X (doi:10.1210/jc.2009-1406)

Reynolds, R. M., Walker, B. R. , Phillips, D. I., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E., and Connell, J. M. (2009) Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53 (6). pp. 932-936. ISSN 0194-911X (doi:10.1161/​HYPERTENSIONAHA.109.129320)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70 (3). pp. 363-371. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2008.03383.x)

Davies, E., Davies, E., Ainsworth, R., Aitken, C., Carman, W., and Kroes, A. (2009) Viral myocarditis. Journal of Clinical Virology, 45 (3). VII-VIX.

Huda, S. S., MacKenzie, S. M., Sattar, N., Fraser, R., Connell, J. M. C., and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69 (6). pp. 848-854. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2008.03262.x )

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E., and Connell, J.M.C. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68 (5). pp. 700-706. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.03116.x )

Connell, J. M.C., MacKenzie, S. M., Freel, E. M., Fraser, R., and Davies, E. (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29 (2). pp. 133-154. ISSN 0163-769X (doi:10.1210/er.2007-0030 )

Ye, P., Kenyon, C. J., MacKenzie, S. M., Nichol, K., Seckl, J. R., Fraser, R., Connell, J. M.C., and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase(CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196 (2). pp. 305-311. ISSN 0022-0795 (doi:10.1677/JOE-07-0439)

MacKenzie, S. M., Dewar, D., Stewart, W., Fraser, R., Connell, J. M. C., and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196 (1). pp. 123-130. ISSN 0022-0795 (doi:10.1677/JOE-07-0427)

Freel, E.M. et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67 (6). pp. 832-838. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.02971.x)

Freel, E.M., Bernhardt, M., Ingram, R., Wallace, A.M., Fraser, R., Davies, E., and Connell, J.M.C. (2007) Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy. Clinical Endocrinology, 66 (5). pp. 659-665. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.02791.x)

Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49 . pp. 113-119. (doi:10.1161/01.HYP.0000249904.93940.7a)

Barr, M., MacKenzie, S., Wilkinson, D., Holloway, C., Friel, E., Miller, S., MacDonald, T., Fraser, R., Connell, J., and Davies, E. (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65 . pp. 816-825. (doi:10.1111/j.1365-2265.2006.02673.x)

Imrie, H. et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91 (12). pp. 5051-5056. ISSN 0021-972X (doi:10.1210/jc.2006-1481)

Connell, J., and Davies, E. (2005) The new biology of aldosterone. Journal of Endocrinology, 186 . pp. 1-20. (doi:10.1677/joe.1.06017)

Imrie, H., Mayosi, B., Baker, M., Fraser, R., Davies, E., Ingram, M., Watkins, H., Farrall, M., Connell, J., and Keavney, B. (2005) Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Journal of Clinical Endocrinology and Metabolism, 90 . pp. 1072-1077. (doi:10.1210/jc.2004-0870)

Freel, E., Shakerdi, L.A., Friel, E., Wallace, A.M., Davies, E., Fraser, R., and Connell, J.M.C. (2004) Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89 (9). pp. 4628-4633. ISSN 0021-972X (doi:10.1210/jc.2004-0379)

Freel, E.M., Shakerdi, L., Friel, E., Wallace, A.M., Davies, E., Fraser, R., and Connell, J.M.C. (2004) The origin of circulating 18-oxo and 18-hydroxycortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89 (9). pp. 4628-4633. ISSN 0021-972X (doi:10.1210/jc.2004-0379)

Kennon, B., Ingram, M., Friel, E., Anderson, N., MacKenzie, S., Davies, E., Shakerdi, L., Wallace, A., Fraser, R., and Connell, J. (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61 . pp. 174-181. (doi:10.1111/j.1365-2265.2004.02073.x)

Connell, J., Fraser, R., MacKenzie, S., and Davies, E. (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41 . pp. 993-999. (doi:10.1161/01.HYP.0000064344.00173.44)

Davies, E., and Kenyon, C. (2003) CYP11B2 polymorphisms and cardiovascular risk factors. [Editorial]. Journal of Hypertension, 21 (7). pp. 1249-1253.

Davies, E., and MacKenzie, S. (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30 . pp. 437-445.

Ye, P., Kenyon, C., MacKenzie, S., Seckl, J., Fraser, R., Connell, J., and Davies, E. (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144 . pp. 3321-3328. (doi:10.1210/en.2003-0109)

Draper, N. et al. (2002) Association Studies between Microsatellite Markers within the Gene Encoding Human 11{beta}-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio, and Glucocorticoid Metabolism. Journal of Clinical Endocrinology and Metabolism, 87 (11). pp. 4984-4990. ISSN 0021-972X (doi:10.1210/jc.2001-011375)

Lim, P., MacDonald, T., Holloway, C., Friel, E., Anderson, N., Dow, E., Jung, R., Davies, E., Fraser, R., and Connell, J. (2002) Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. Journal of Clinical Endocrinology and Metabolism, 87 (9). pp. 4398-4402.

MacKenzie, S.M., Fraser, R., Connell, J.M.C., and Davies, E. (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-Angiotensin-Aldosterone System, 3 . pp. 214-221. ISSN 1470-3203

MacKenzie, S., Lai, M., Clark, C., Fraser, R., Gomez-Sanchez, C., Seckl, J., Connell, J., and Davies, E. (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29 (3). pp. 319-325. (doi:10.1677/jme.0.0290319)

Connell, J.M.C., Fraser, R., and Davies, E. (2001) Disorders of mineralocorticoid synthesis. Best Practice and Research: Clinical Endocrinology and Metabolism, 15 . pp. 43-60. ISSN 1521-690X (doi:10.1053/beem.2000.0118)

Davies, E., Holloway, C., Ingram, M., Friel, E., Inglis, G., Swan, L., Hillis, W., Fraser, R., and Connell, J. (2001) An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects. Clinical Endocrinology, 54 . pp. 813-817.

Fisher, A., Friel, E., Bernhardt, R., Gomez-Sanchez, C., Connell, J., Fraser, R., and Davies, E. (2001) Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11 beta-hydroxylase. Journal of Clinical Endocrinology and Metabolism, 86 . pp. 4326-4329.

Inglis, G., Plouin, P., Friel, E., Davies, E., Fraser, R., and Connell, J. (2001) Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). Clinical Endocrinology, 54 . pp. 725-730.

Clark, C.J., Davies, E., Anderson, N.H., Farmer, R., Friel, E.C., Fraser, R., and Connell, J.M.C. (2000) alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. Hypertension, 36 (6). pp. 990-994. ISSN 0194-911X

MacKenzie, S., Clark, C., Ingram, M., Lai, M., Seckl, J., Gomez-Sanchez, C., Fraser, R., Connell, J., and Davies, E. (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26 (4). pp. 531-535.

This list was generated on Fri Oct 31 07:51:49 2014 GMT.