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Mancia, G et al. (2009) Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Journal of Hypertension, 27 (11). pp. 2121-2158.

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53 (4). pp. 694-700. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.108.122333)

Mischak, H, Coon, JJ, Novak, J, Weissinger, EM, Schanstra, JP, and Dominiczak, AF (2009) Capillary Electrophoresis-Mass Spectrometry As A Powerful Tool in Biomarker Discovery and Clinical Diagnosis: An Update of Recent Developments. Mass Spectrometry Reviews, 28 (5). pp. 703-724. ISSN 0277-7037 (doi:10.1002/mas.20205 )

Org, E et al. (2009) Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Human Molecular Genetics, 18 (12). pp. 2288-2296.

Padmanabhan, S, Menni, C, Prabhakaran, D, and Dominiczak, AF (2009) Discovering the genetic determinants of complex diseases. Current Science, 97 (3). pp. 385-391.

zur Muhlen, C et al. (2009) Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients. Journal of Proteome Research, 8 (1). pp. 335-345. ISSN 1535-3893 (doi:10.1021/pr800615t )

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19 (9). pp. 309-316. ISSN 1043-2760 (doi:10.1016/j.tem.2008.07.010 )

Berry, C., Zimmerli, L.U., Steedman, T., Foster, J.E., Dargie, H.J., Berg, H.A., Dominiczak, A.F., and Delles, C. (2008) Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting. Clinical Science, 114 (6). pp. 423-430. ISSN 0140-8736 (doi:10.1042/CS20070337)

Carty, D, Delles, C, and Dominiczak, AF (2008) Novel Biomarkers for Predicting Preeclampsia. Trends in Cardiovascular Medicine, 18 (5). pp. 186-194. ISSN 1050-1738 (doi:10.1016/j.tcm.2008.07.002)

Caulfield, M.J. et al. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Medicine, 5 (10). e197. ISSN 1549-1277 (doi:10.1371/journal.pmed.0050197 )

Coon, J.J. et al. (2008) CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clinical Applications, 2 (7-8). pp. 964-973. ISSN 1862-8346 (doi:10.1002/prca.200800024)

Delles, C, Miller, W. H., and Dominiczak, A. F. (2008) Targeting reactive oxygen species in hypertension. Antioxidants and Redox Signaling, 10 (6). pp. 1061-1077. ISSN 1523-0864 (doi:10.1089/ars.2007.2008 )

Delles, C, Neisius, U, Dymott, JA, Carty, D, Rocchiccioli, JP, Bryce, GJ, Berg, GA, Hamilton, CA, and Dominiczak, AF (2008) Strategies to target cholesterol levels lead to improved endothelial function in patients with coronary artery disease (CAD). Journal of Hypertension, 26 . S325-S325. ISSN 0263-6352

Delles, C et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26 (7). pp. 1343-1352. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282fe1d67)

Dymott, J.A., Chow, C., Rocchiccioli, J.P., Berg, G.A., Cherry, A.K.L., Delles, C., Hamilton, C.A., and Dominiczak, A.F. (2008) Endothelial function in patients undergoing coronary artery by-pass grafting is improved in patients in 2006 compared to 2003. Scottish Medical Journal , 53 (1). p. 57. ISSN 0036-9330

Hastie, C, Padmanabhan, S, Slack, R, Dominiczak, AF, and Pell, J (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26 . S113-S113. ISSN 0263-6352

Miller, WH, Graham, D, Douglas, K, MacKenzie, RM, and Dominiczak, AF (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22 (10). pp. 736-737. ISSN 0950-9240

Miller, WH, Graham, D, Douglas, K, Mackenzie, R, Huynh, N, and Dominiczak, AF (2008) Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains. Journal of Hypertension, 26 (Suppl.). S340-S341. ISSN 0263-6352

Moreno, MU, Dymott, J, Taurino, C, Berg, G, Carty, D, Mc Culloch, J, Delles, C, and Dominiczak, AF (2008) Whole blood and mononuclear cell superoxide generation are increased in patients with coronary artery disease. Journal of Hypertension, 26 . S308-S308.

Moreno, MU, Dymott, J, Taurino, C, Carty, D, Mc Culloch, J, Delles, C, and Dominiczak, AF (2008) Exercise attenuates superoxide release in whole blood and mononuclear cells in patients with coronary artery disease. Journal of Hypertension, 26 . S320-S320.

Padmanabhan, S, Melander, O, Hastie, C, Menni, C, Delles, C, Connell, J, and Dominiczak, AF (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26 (7). pp. 1275-1281.

Padmanabhan, S, Menni, C, Lee, WK, Brambilla, P, Laing, S, Sega, R, Cesana, G, Mancia, G, and Dominiczak, AF (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26 . S18-S18.

Tian, T., McBride, M.W., Graham, D., Touyz, R., and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26 (Suppl.). S148-S148. ISSN 0263-6352

Tonyz, R, Aranha, A, Yogi, A, Graham, D, McBride, MW, Callera, G, Montezano, A, Coimbra, T, and Dominiczak, AF (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26 (Suppl.). S329-S329. ISSN 0263-6352

Wallace, C. et al. (2008) Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. American Journal of Human Genetics, 82 (1). pp. 139-149. (doi:10.1016/j.ajhg.2007.11.001)

Weedon, MN et al. (2008) Genome-wide association analysis identifies 20 loci that influence adult height. Nature Genetics, 40 (5). pp. 575-583.

Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7 (2). pp. 290-298. ISSN 1535-9476 (doi:10.1074/mcp.M700394-MCP200)

Zulategui, MUM, Dymott, JA, Taurino, C, Berg, GA, Rocchiccioli, JP, Delles, C, and Dominiczak, AF (2008) Superoxide release by whole blood and mononuclear cells as markers of oxidative stress in patients with coronary artery disease. Journal of Human Hypertension, 22 (10). p. 733.

de Ujue, M, Zulategui, M, Dymott, JA, Taurino, C, Berg, GA, Rocchiccioli, P, Delles, C, and Dominiczak, AF (2008) Relationship between whole blood and mononuclear cell superoxide levels in patients with coronary artery disease. Hypertension, 52 (4). E55-E56. ISSN 0194-911X

Bailey, SL et al. (2007) Mutations in the gene encoding the 3 '-5 ' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature Genetics, 39 . pp. 1065-1067. (doi:10.1038/ng2091)

Barr, M et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49 . pp. 113-119. (doi:10.1161/01.HYP.0000249904.93940.7a)

Burton, P.R. et al. (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447 (7145). pp. 661-678. ISSN 0028-0836 (doi:10.1038/nature05911)

Burton, Paul R et al. (2007) Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39 (11). pp. 1329-1337. ISSN 1061-4036 (doi:10.1038/ng.2007.17)

Chow, CK, Pell, AC, Walker, A, O'Dowd, C, Dominiczak, AF, and Pell, JP (2007) Families of patients with premature coronary heart disease: an obvious but neglected target for primary prevention. British Medical Journal, 335 . pp. 481-485. ISSN 0959-535X

Freel, EM et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67 . pp. 832-838. (doi:10.1111/j.1365-2265.2007.02971.x)

Good, DM, Thongboonkerd, V, Novak, J, Bascands, JL, Schanstra, JP, Coon, JJ, Dominiczak, A, and Mischak, H (2007) Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. Journal of Proteome Research, 6 (12). pp. 4549-4555. ISSN 1535-3893

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50 . pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Jakubowska, J, Hunt, E, Chalmers, M, McBride, M, and Dominiczak, A.F. (2007) VisGenome: visualization of single and comparative genome representations. Bioinformatics, 23 . pp. 2641-2642. (doi:10.1093/bioinformatics/btm394)

Lee-Kirsch, MA et al. (2007) Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature Genetics, 39 (9). pp. 1065-1067. ISSN 1061-4036 (doi:10.1038/ng2091 )

Mancia, G et al. (2007) [ESH/ESC 2007 Guidelines for the management of arterial hypertension]. Rev Esp Cardiol, 60 (9). pp. 968-994.

Mancia, G et al. (2007) 2007 Guidelines for the management of arterial hypertension - The task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC). European Heart Journal, 28 . pp. 1462-1536. (doi:10.1093/eurheartj/ehm236)

Mancia, G et al. (2007) 2007 ESH-ESC practice guidelines for the management of arterial hypertension - ESH-ESC task force on the management of arterial hypertension. Journal of Hypertension, 25 . pp. 1751-1762.

Mancia, G. et al. (2007) [Practice guidelines 2007 for the treatment of arterial hypertension]. Giornale Italiano di Cardiologia, 8 (7). pp. 389-479.

Mansia, G et al. (2007) 2007 ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Blood Press, 16 (3). pp. 135-232.

Marcano, AC et al. (2007) Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. Journal of Medical Genetics, 44 . (doi:10.1136/jmg.2007.049718)

Nawrot, TS, Staessen, JA, Roels, HA, Den Hond, E, Thijs, L, Fagard, RH, Dominiczak, AF, and Struijker-Boudier, HA (2007) Blood pressure and blood selenium: a cross-sectional and longitudinal population study. European Heart Journal, 28 . pp. 628-633. (doi:10.1093/eurheartj/ehl479)

Newhouse, S et al. (2007) Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes. Journal of Human Hypertension, 21 (10). p. 831.

Newhouse, SJ et al. (2007) Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis. Circulation Research, 101 (11). p. 1208.

Padmanabhan, S et al. (2007) Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. Journal of Human Hypertension, 21 (10). p. 837.

Padmanabhan, S et al. (2007) Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study. Journal of Human Hypertension, 21 (10). p. 843.

Shankar, RR, Charchar, FJ, Eckert, GJ, Saha, C, Tu, W, Dominiczak, AF, and Pratt, JH (2007) Studies of an association in boys of blood pressure and the Y chromosome. American Journal of Hypertension, 20 . pp. 27-31. (doi:10.1016/j.amjhyper.2006.06.013)

Tomaszewski, M, Charchar, FJ, Lynch, MD, Padmanabhan, S, Wang, WY, Miller, WH, Grzeszczak, W, Maric, C, Zukowska-Szczechowska, E, and Dominiczak, AF (2007) Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation, 116 (17). pp. 1915-1924.

Tomaszewski, M, Charchar, FJ, Lynch, MD, Padmanabhan, S, Wang, WYS, Miller, WH, Grzeszczak, W, Maric, C, Zukowska-Szczechowska, E, and Dominiczak, AF (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116 . pp. 1915-1924. (doi:10.1161/CIRCULATIONAHA.107.710293)

Tomaszewski, M, Charchar, FJ, Maric, C, McClure, J, Crawford, L, Grzeszczak, W, Sattar, N, Zukowska-Szczechowska, E, and Dominiczak, AF (2007) Glomerular hyperfiltration: A new marker of metabolic risk. Kidney International, 71 . pp. 816-821. ISSN 0085-2538 (doi:10.1038/sj.ki.5002160)

Wallace, C et al. (2007) Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease. Circulation Research, 101 (11). p. 1208.

Zimmerli, LU, Mark, PB, Steedman, T, Foster, JE, Berg, GA, Dargie, HJ, Jardine, AG, Delles, C, and Dominiczak, AF (2007) Vascular function in patients with end-stage renal disease and/or coronary artery disease: A cardiac magnetic resonance imaging study. Kidney International, 71 . pp. 68-73. ISSN 0085-2538 (doi:10.1038/sj.ki.5002024)

Al Benna, S., Hamilton, C.A., McClure, J.D., Rogers, P.N., Berg, G.A., Ford, I., Delles, C., and Dominiczak, A.F. (2006) Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arteriosclerosis, Thrombosis and Vascular Biology, 26 . pp. 218-223. ISSN 1079-5642 (doi:10.1161/01.ATV.0000193626.22269.45)

Bell, JT et al. (2006) Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. Human Molecular Genetics, 15 . pp. 1365-1374. (doi:10.1093/hmg/ddl058)

Delles, C et al. (2006) Association between variants of the human GSTM gene family and hypertension. Hypertension, 48 (4). E27-E27. ISSN 0194-911X

Delles, C, and Dominiczak, AF (2006) Vascular failure or sick vessel syndrome: The cardiovascular continuum is a useful concept for clinical research. Journal of Hypertension, 24 (11). pp. 2147-2148. ISSN 0263-6352

Delles, C et al. (2006) Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension. Journal of Hypertension, 24 . S13-S13.

Hamilton, CA, Groves, S, Carswell, HV, Brosnan, MJ, Graham, D, and Dominiczak, AF (2006) Estrogen treatment enhances nitric oxide bioavailability in normotensive but not hypertensive rats. American Journal of Hypertension, 19 . pp. 859-866. (doi:10.1016/j.amjhyper.2006.01.008)

Ibrahim, J., McGee, A., Graham, D., McGrath, J.C., and Dominiczak, A.F. (2006) Sex-specific differences in cerebral arterial myogenic tone in hypertensive and normotensive rats. American Journal of Physiology: Heart and Circulatory Physiology, 290 . H1081-H1089. ISSN 0363-6135 (doi:10.1152/ajpheart.00752.2005)

McBride, MW, Graham, D, Delles, C, and Dominiczak, AF (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15 . pp. 145-151.

Munroe, PB et al. (2006) Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British genetics of hypertension study. Hypertension, 48 . pp. 105-111. (doi:10.1161/01.HYP.0000228324.74255.f1)

Padmanabhan, S et al. (2006) Genomewide linkage analysis for loci affecting electrocardiographic LV mass. Journal of Hypertension, 24 . S330-S330.

Padmanabhan, S et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47 . pp. 603-608. (doi:10.1161/01.HYP.0000197947.62601.9d)

Smith, B.H. et al. (2006) Generation Scotland: the Scottish family health study; a new resource for researching genes and heritability. BMC Medical Genetics, 7 . p. 74. ISSN 1471-2350 (doi:10.1186/1471-2350-7-74 )

Tomaszewski, M, Moreno, MU, Charchar, FJ, Zukowska-Szczechowska, E, and Dominiczak, AF (2006) Functional significance of single nucleotide polymorphisms within the 5'-flanking region of beta2-adrenergic receptor gene. Journal of Hypertension, 24 (12). pp. 2473-2474. ISSN 0263-6352

Tomaszewski, M, Zimmerli, L, Charchar, FJ, and Dominiczak, AF (2006) Genetic information in the diagnosis and treatment of hypertension. Current Hypertension Reports, 8 . pp. 309-316.

Wallace, C et al. (2006) Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. American Journal of Human Genetics, 79 . pp. 323-331.

Tomaszewski, M., Charchar, F.J., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. (2005) Letter re: Inflammation and lipoprotein changes with protracted exercise. Journal of Clinical Endocrinology and Metabolism, 90 (8). p. 4981. ISSN 0021-972X

Brain, N.J.R., and Dominiczak, A.F. (2005) Pharmacogenomics in hypertension: present practicalities and future potential. Journal of Hypertension, 23 (7). pp. 1327-1329. ISSN 0263-6352

Brain, N.J.R., Charchar, F.J., Delles, C., Dominiczak, A.F., Graham, D., Hamilton, C.A., Lee, W.K., McGride, M.W., and Tomaszewski, M. (2005) Cardiovascular genomics and oxidative stress. Hypertension, 45 (4). pp. 636-642. ISSN 0194-911X

Carswell, HV, Dominiczak, AF, Garcia-Segura, LM, Harada, N, Hutchison, JB, and Macrae, IM (2005) Brain aromatase expression after experimental stroke: Topography and time course. Journal of Steroid Biochemistry and Molecular Biology, 96 . pp. 89-91. (doi:10.1016/j.jsbmb.2005.02.016)

Carswell, HV, McBride, MW, Graham, D, Dominiczak, AF, and Macrae, IM (2005) Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Methods in Molecular Medicine, 104 . pp. 49-74.

Collison, M, James, DJ, Graham, D, Holman, GD, Connell, JMC, Dominiczak, A.F., Gould, GW, and Salt, IP (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia, 48 (3). pp. 539-546. ISSN 0012-186X (doi:10.1007/s00125-005-1674-x)

Dominiczak, A (2005) Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. American Journal of Human Genetics, 77 (1). pp. 127-131. ISSN 0002-9297 (doi:10.1086/431245)

Dominiczak, AF, Graham, D, McBride, MW, Brain, NJ, Lee, WK, Charchar, FJ, Tomaszewski, M, Delles, C, and Hamilton, CA (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45 (4). pp. 636-642.

Graham, D, McBride, MW, Brain, NJ, and Dominiczak, AF (2005) Congenic/consomic models of hypertension. Methods in Molecular Medicine, 108 . pp. 3-15.

McBride, MW et al. (2005) Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension, 45 . pp. 786-792. (doi:10.1161/01.HYP.0000154879.49245.39)

McCallum, RW, Hamilton, CA, Graham, D, Jardine, E, Connell, JM, and Dominiczak, AF (2005) Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats. Journal of Hypertension, 23 . pp. 351-358.

McCallum, RW, Sainsbury, CA, Spiers, A, Dominiczak, AF, Petrie, JR, Sattar, N, and Connell, JM (2005) Growth hormone replacement reduces C-reactive protein and large-artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency. Clinical Endocrinology, 62 (4). pp. 473-479. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2005.02245.x)

McGill, J.K., Gallagher, L., Carswell, H.V.O., Irving, E.A., Dominiczak, A.F., and Macrae, I.M. (2005) Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke, 36 (1). pp. 135-141. ISSN 0039-2499 (doi:10.1161/01.STR.0000149629.32525.b7)

Miller, WH, Brosnan, MJ, Graham, D, Nicol, CG, Morecroft, I, Channon, KM, Danilov, SM, Reynolds, PN, Baker, AH, and Dominiczak, AF (2005) Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Molecular Therapy, 12 . pp. 321-327. (doi:10.1016/j.ymthe.2005.02.025)

Nemoto, K. et al. (2005) No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats. Hypertension Research, 28 (2). pp. 155-163. ISSN 0916-9636

Newhouse, SJ et al. (2005) Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Human Molecular Genetics, 14 . pp. 1805-1814. (doi:10.1093/hmg/ddi187)

Padmanabhan, S., Munroe, P.B., Brown, M., Clayton, D., Farrall, M., Webster, J., Lathrop, M., Caulfield, M., Dominiczak, A.F., and Connell, J. (2005) Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study. Hypertension, 46 (4). p. 886. ISSN 0194-911X

Strahorn, P, Graham, D, Charchar, FJ, Sattar, N, McBride, MW, and Dominiczak, AF (2005) Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 23 . pp. 2179-2186.

Wallace, C et al. (2005) Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study. p. 877.

McBride, M.W., Charchar, F.J., Graham, D., Miller, W.H., Strahorn, P., Carr, F.J., and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554 . pp. 56-63. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.049361)

Antier, D, Carswell, HV, Brosnan, MJ, Hamilton, CA, Macrae, IM, Groves, S, Jardine, E, Reid, JL, and Dominiczak, AF (2004) Increased levels of superoxide in brains from old female rats. Free Radical Research, 38 . pp. 177-183. (doi:10.1080/10715760310001643294)

Beattie, E, Dominiczak, AF, Graham, D, Hamilton, C, and Spiers, A (2004) Comparison of the effects of omapatrilat and irbesartan hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. Journal of Hypertension, 22 . pp. 329-337. (doi:10.1097/01.hjh.0000098240.58662.93)

Carswell, H.V., Bingham, D., Wallace, K., Nilsen, M., Graham, D.I., Dominiczak, A.F., and Macrae, I.M. (2004) Differential effects of 17beta-estradiol upon stroke damage in stroke prone and normotensive rats. Journal of Cerebral Blood Flow and Metabolism, 24 (3). pp. 298-304. ISSN 0271-678X

Carswell, HV, Bingham, D, Wallace, K, Nilsen, M, Graham, DI, Dominiczak, AF, and Macrae, IM (2004) Differential effects of 17 beta-estradiol upon stroke damage in stroke prone and normotensive rats. Journal of Cerebral Blood Flow and Metabolism, 24 . pp. 298-304. (doi:10.1097/01.WCB.0000112322.75217.FD)

Charchar, F., Padmanabhan, S., Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A., Connell, J.M., Watt, G.C.M., Dominiczak, A.F., and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22 (S1). S58-S59. ISSN 0952-1178

Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. (2004) Association of the human Y chromosome with cholesterol levels in the general population. Arteriosclerosis, Thrombosis and Vascular Biology, 24 . pp. 308-312. ISSN 1079-5642 (doi:10.1161/01.ATV.0000113291.39267.0a)

Dominiczak, AF, Brain, N, Charchar, F, McBride, M, Hanlon, N, and Lee, WK (2004) Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes. Clinical and Experimental Hypertension, 26 . pp. 611-620. (doi:10.1081/CEH-200031939)

Graham, D., Hamilton, C., Beattie, E., Spiers, A., and Dominiczak, A.F. (2004) Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. Journal of Hypertension, 22 (2). pp. 329-337. ISSN 0263-6352

Hamilton, CA, Miller, WH, Al Benna, S, Brosnan, MJ, Drummond, RD, McBride, MW, and Dominiczak, AF (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clinical Science, 106 . pp. 219-234. (doi:10.1042/CS20030379)

Hunt, E., Hanlon, N., Leader, D.P., Bryce, H., and Dominiczak, A.F. (2004) The visual language of synteny. OMICS: A Journal of Integrative Biology, 8 . pp. 289-305.

Kuznetsova, T et al. (2004) Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake. Journal of Hypertension, 22 (2). pp. 287-295. ISSN 0263-6352

Newhouse, S et al. (2004) No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. Journal of Hypertension, 22 . S212-S212.

Padmanabhan, S., Connell, J.M.C., Dominiczak, A.F., Inglis, G., Macfarlane, P.W., and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22 (S1). S180-S181. ISSN 0952-1178

Tomaszewski, M, Charchar, FJ, Crawford, L, Zukowska-Sczechowska, E, Grzeszczak, W, Sattar, N, and Dominiczak, AF (2004) Serum C-reactive protein and lipids in ultra-marathon runners. American Journal of Cardiology, 94 . pp. 125-126. (doi:10.1016/j.amjcard.2004.03.043)

Tomaszewski, M, Charchar, FJ, Lacka, B, Pesonen, U, Wang, WY, Zukowska-Szczechowska, E, Grzeszczak, W, and Dominiczak, AF (2004) Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. pp. 689-694.

Tomaszewski, M, Charchar, FJ, Lacka, B, Pesonen, U, Wang, WYS, Zukowska-Szczechowska, E, Grzeszczak, W, and Dominiczak, AF (2004) Epistatic interaction between beta(2)-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Hypertension, 44 . pp. 689-694. (doi:10.1161/01.HYP.0000143844.81979.61)

Stanton, T., Payne, J.R., Montgomery, H.E., Watt, G., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2003) Genetic determinants of left ventricular mass: the role of beta-1 adrenoceptor variation in normal, athletic, and disease populations. Journal of the American College of Cardiology, 41 (6 (S1)). p. 273. ISSN 0735-1097 (doi:10.1016/S0735-1097(03)82282-9)

Brown, MJ, Cruickshank, JK, Dominiczak, AF, MacGregor, GA, Poulter, NR, Russell, GI, Thom, S, and Williams, B (2003) Better blood pressure control: how to combine drugs. Journal of Human Hypertension, 17 . pp. 81-86. (doi:10.1038/sj.jhh.1001511)

Caulfield, M et al. (2003) Genome-wide mapping of human loci for essential hypertension. Lancet, 361 . pp. 2118-2123.

Charchar, FJ, Dominiczak, A.F., Grzeszczak, W, Padmanabhan, S, Tomaszewski, M, and Zukowska-Szczechowska, E (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17 (6). pp. 379-380.

Charchar, FJ, Tomaszewski, M, Strahorn, P, Champagne, B, and Dominiczak, AF (2003) Y is there a risk to being male? Trends in Endocrinology and Metabolism, 14 . pp. 163-168. ISSN 1043-2760 (doi:10.1016/S1043-2760(02)00032-8)

Dominiczak, A.F., and McBride, M.W. (2003) Genetics of common polygenic stroke. Nature Genetics, 35 (2). pp. 116-117.

Izzard, A.S., Graham, D., Burnham, M.P., Heerkens, E.H., Dominiczak, A.F., and Heagerty, A.M. (2003) Myogenic and structural properties of cerebral arteries from the stroke-prone spontaneously hypertensive rat. American Journal of Physiology: Heart and Circulatory Physiology, 285 . H1489-H1494. ISSN 0363-6135 (doi:10.1152/ajpheart.00352.2003)

Khan, I.Y., Taylor, P.D., Dekou, V., Seed, P.T., Lakasing, L., Graham, D., Dominiczak, A.F., Hanson, M.A., and Poston, L. (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension, 41 (1). pp. 168-175. ISSN 0194-911X

Khan, LY, Taylor, PD, Dekou, V, Seed, PT, Lakasing, L, Graham, D, Dominiczak, AF, Hanson, MA, and Poston, L (2003) Gender-linked hypertension in offspring of lard-fed pregnant rat. Hypertension, 41 . pp. 168-175. (doi:10.1161/01.HYP.0000047511.97879.FC)

McBride, MW, Carr, FJ, Graham, D, Anderson, NH, Clark, JS, Lee, WK, Charchar, FJ, Brosnan, MJ, and Dominiczak, AF (2003) Microarray analysis of rat chromosome 2 congenic strains. Hypertension, 41 . pp. 847-853. (doi:10.1161/01.HYP.0000047103.07205.03)

Pell, J, Smith, GC, Dominiczak, AF, Cobbe, S, Dobbie, R, McMahon, AD, and Ford, I (2003) Family history of premature death from ischaemic heart disease is associated with an increased risk of delivering a low birth weight baby. Heart, 89 (10). pp. 1249-1250. (doi:10.1136/heart.89.10.1249 )

Stanton, T, Robb, SD, Payne, JR, Montgomery, HE, Watt, G, McDonagh, TA, Dominiczak, AF, Connell, J, and Dargie, HJ (2003) The effect of beta-1 adrenoceptor genetic variation on left ventricular mass. Circulation, 108 (17). p. 180.

Tomaszewski, M. et al. (2003) Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? Arteriosclerosis, Thrombosis and Vascular Biology, 23 (9). pp. 1640-1644. ISSN 1079-5642 (doi:10.1161/01.ATV.0000087036.75849.0B)

Ye, P et al. (2003) Cardiac aldosterone synthase (CYP11B2) gene expression is not increased in the fibrotic heart. p. 635.

Tomaszewski, M. et al. (2002) Essential hypertension and beta(2)-adrenergic receptor gene linkage and association analysis. Hypertension, 40 (3). pp. 286-291. ISSN 0194-911X

Brosnan, MJ, Hamilton, CA, Graham, D, Lygate, CA, Jardine, E, and Dominiczak, AF (2002) Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats. Journal of Hypertension, 20 . pp. 281-286.

Carr, F.J., Negrin, C.D., Clark, J.S., Graham, D., McBride, M.W., Anderson, N.W., and Dominiczak, A.F. (2002) Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. Scottish Medical Journal , 47 (1). pp. 7-9. ISSN 0036-9330

Carr, FJ, McBride, MW, Carswell, HV, Graham, D, Strahorn, P, Clark, JS, Charchar, FJ, and Dominiczak, AF (2002) Genetic aspects of stroke: Human and experimental studies. Journal of Cerebral Blood Flow and Metabolism, 22 . pp. 767-773.

Caulfield, M et al. (2002) The MRC British Genetics of Hypertension Study - Genome-wide screen results. Journal of Hypertension, 20 . S7-S7.

Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39 . pp. 353-356. ISSN 0194-911X

Duncan, AC, Petrie, JR, Brosnan, MJ, Devlin, AM, Bass, RA, Charnock-Jones, DS, Connell, JM, Dominiczak, AF, and Lumsden, MA (2002) Is estradiol cardioprotection a nitric oxide-mediated effect? Human Reproduction, 17 (7). pp. 1918-1923. ISSN 0268-1161 (doi:10.1093/humrep/17.7.1918)

Fennell, JP, Brosnan, MJ, Frater, AJ, Hamilton, CA, Alexander, MY, Nicklin, SA, Heistad, DD, Baker, AH, and Dominiczak, AF (2002) Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Therapy, 9 . pp. 110-117. (doi:10.1038/sj/gt/3301633)

Hamilton, CA, Brosnan, MJ, Al Benna, S, Berg, G, and Dominiczak, AF (2002) NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension, 40 (5). pp. 755-762.

Hamilton, CA, O'Dowd, G, McIntosh, L, Berg, G, Butler, J, Pathi, V, Williams, R, Reid, JL, and Dominiczak, AF (2002) Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries. Atherosclerosis, 160 . pp. 345-353. ISSN 0021-9150

McBride, MW, Carswell, HV, Graham, D, Carr, FJ, Charchar, FJ, Macrae, IM, and Dominiczak, AF (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22 . pp. 127-134. (doi:10.1053/snep.2002.30213)

McCallum, R.W., Hamilton, C., Graham, D., Jardine, E., Dominiczak, A.F., and Connell, J. (2002) Hypertensive but not normotensive rat arteries display impaired nitric oxide-dependant vasodilatation to insulin-like growth factor and insulin. Journal of Hypertension, 20 . S284-S284.

McCallum, RW, Petrie, JR, Dominiczak, AF, and Connell, JM (2002) Growth hormone deficiency and vascular risk. Clinical Endocrinology, 57 (1). pp. 11-24. ISSN 0300-0664 (doi:10.1046/j.1365-2265.2002.01559.x)

Padmanabhan, S, Padmanabhan, A, Dominiczak, A.F., and Connell, J (2002) A web-based hypertension genetics resource. Journal of Hypertension, 20 . S24-S24.

Stanton, T., Inglis, G.C., Padmanabhan, S., Dominiczak, A.F., Jardine, A.G., and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15 (5). pp. 512-518.

Stanton, T., Padmanabhan, S., Payne, J.R., Watt, G., Montgomery, H.E., Jardine, A.G., Dominiczak, A.F., and Connell, J. (2002) The role of beta-1 adrenoceptor variation in determining LV mass in normal, athletic and disease populations. Hypertension, 40 (4). p. 576. ISSN 0194-911X

Berry, C, Anderson, N, Kirk, AJ, Dominiczak, AF, and McMurray, JJ (2001) Renin angiotensin system inhibition is associated with reduced free radical concentrations in arteries of patients with coronary heart disease. Heart, 86 (2). pp. 217-220.

Berry, C, Brosnan, MJ, Alexander, MY, Hamilton, CA, McMurray, JJ, and Dominiczak, A.F. (2001) Mechanisms of oxidative free radical generation in human arteries. Clinical Science , 101 (2). 7P.

Berry, C, Brosnan, MJ, Fennell, J, Hamilton, CA, and Dominiczak, AF (2001) Oxidative stress and vascular damage in hypertension. Current Opinion in Nephrology and Hypertension, 10 . pp. 247-255.

Berry, C., Touyz, R., Dominiczak, A.F., Webb, R.C., and Johns, D.G. (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology: Heart and Circulatory Physiology, 281 . H2337-H2365. ISSN 0363-6135

Cohuet, G, Challande, P, Osborne-Pellegrin, M, Arribas, SM, Dominiczak, A, Louis, H, Laurent, S, and Lacolley, P (2001) Mechanical strength of the isolated carotid artery in SHR. Hypertension, 38 . pp. 1167-1171.

De Lange, R.P., Burr, K., Clark, J.S., Negrin, C.D., Brosnan, M.J., St Clair, D.M., Dominiczak, A.F., and Shaw, D.J. (2001) Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke. Neurogenetics, 3 (2). pp. 99-106.

Dorrance, AM, Graham, D, Webb, RC, Fraser, R, and Dominiczak, A (2001) Increased membrane sphingomyelin and arachidonic acid in stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 14 . pp. 1149-1153.

Hamilton, C.A., McPhaden, A.R., Berg, G., Pathi, V., and Dominiczak, A.F. (2001) Is hydrogen peroxide an EDHF in human radial arteries? American Journal of Physiology: Heart and Circulatory Physiology, 280 . H2451-H2455. ISSN 0363-6135

Hamilton, CA, Brosnan, MJ, McIntyre, M, Graham, D, and Dominiczak, AF (2001) Superoxide excess in hypertension and aging - A common cause of endothelial dysfunction. Hypertension, 37 . pp. 529-534.

James, D.J., Cairns, F., Salt, I.P., Murphy, G.J., Dominiczak, A.F., Connell, J.M.C., and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50 (9). pp. 2148-2156. ISSN 0012-1797 (doi:10.2337/diabetes.50.9.2148 )

Jamieson, A., Ingham, D.G., Dominiczak, A.F., and Connell, J.M. (2001) Not the usual cause of superior vena cava obstruction. Scottish Medical Journal , 46 (2). pp. 51-52. ISSN 0036-9330

Knight, J et al. (2001) No support for linkage of chromosome 17(q21-24) to Essential Hypertension in the MRC British Genetics of Hypertension (MRC BRIGHT) Study. American Journal of Human Genetics, 69 (4). p. 559.

MacKay, AJ, Hamilton, CA, McArthur, K, Berg, G, Tropeano, AI, Boutouyrie, P, Reid, JL, and Dominiczak, AF (2001) Radial artery hypertrophy occurs in coronary atherosclerosis and is independent of blood pressure. Clinical Science, 100 . pp. 509-516.

MacKenzie, C.J., Wakefield, J.M., Cairns, F., Dominiczak, A.F., and Gould, G.W. (2001) Regulation of glucose transport in aortic smooth muscle cells by cAMP and cGMP. Biochemical Journal, 353 . pp. 513-519. ISSN 0264-6021

Marks, L, Carswell, HVO, Peters, EE, Graham, DI, Patterson, J, Dominiczak, AF, and Macrae, IM (2001) Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension, 38 . pp. 116-122.

McCallum, RW, Hamilton, C, Graham, D, Jardine, E, Connell, J, and Dominiczak, A. F. (2001) Insulin-like growth factor acts as a NO-dependant vasodilator in normotensive but not hypertensive rat arteries. p. 968.

Negrin, CD, McBride, MW, Carswell, HVO, Graham, D, Carr, FJ, Clark, JS, Jeffs, B, Anderson, NH, Macrae, IM, and Dominiczak, AF (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37 . pp. 391-397.

Nicklin, SA, Reynolds, PN, Brosnan, MJ, White, SJ, Curiel, DT, Dominiczak, AF, and Baker, AH (2001) Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension, 38 . pp. 65-70.

Nicklin, SA, Von Seggern, DJ, Work, LM, Pek, DC, Dominiczak, AF, Nemerow, GR, and Baker, AH (2001) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Molecular Therapy, 4 . pp. 534-542. (doi:10.1006/mthe.2001.0489)

Petrie, JR, Collison, M, Connell, J, Gould, GW, and Dominiczak, AF (2001) CD36 deficiency and insulin resistance. Lancet, 358 (9277). pp. 242-243. ISSN 0140-6736 (doi:10.1016/S0140-6736(01)05428-9)

Stanton, T, Jardine, A. G., Dominiczak, A. F., and Connell, J (2001) Genetic determinants of left ventricular mass: The role of beta-1 adrenoceptor variation. Circulation, 104 (17). p. 197. ISSN 0009-7322

Zicha, J, Negrin, CD, Dobesova, Z, Carr, F, Vokurkova, M, McBride, MW, Kunes, J, and Dominiczak, AF (2001) Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene. Physiol Genomics, 6 (2). pp. 99-104.

Caulfield, M et al. (2000) A new tool for checks of data precision within the MRC British genetics of hypertension study. Journal of Hypertension, 18 . S180-S180.

Collison, M, Campbell, IW, Salt, IP, Dominiczak, AF, Connell, J, Lyall, H, and Gould, GW (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43 (11). pp. 1374-1380. ISSN 0012-186X (doi:10.1007/s001250051541)

Collison, M, Glazier, AM, Graham, D, Morton, JJ, Dominiczak, MH, Aitman, TJ, Connell, J, Gould, GW, and Dominiczak, A. F. (2000) Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat. Diabetes, 49 (12). pp. 2222-2226.

Graham, D, Collison, M, Glazier, A, Morton, J, Aitman, T, Connell, J, Gouid, G, and Dominiczak, A. F. (2000) Cd36 gene and molecular mechanisms in insulin resistance in the SHRSP. Journal of Hypertension, 18 . S173-S173.

Munroe, PB et al. (2000) Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. American Journal of Human Genetics, 67 (4). p. 304.

Dominiczak, AF, Jeffs, B, and Connell, J (1998) New genetic concepts in hypertensive cardiovascular disease. Current Opinion in Cardiology, 13 (5). pp. 304-311.

Jeffs, B., Clark, J.S., Anderson, N.H., Gratton, J., Brosnan, M.J., Gauguier, D., Reid, J.L., Macrae, I.M., and Dominiczak, A.F. (1997) Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nature Genetics, 16 (4). pp. 364-367. ISSN 1061-4036 (doi:10.1038/ng0897-364)

Harden, PN, MacLeod, MJ, Rodger, RSC, Baxter, GM, Connell, J, Dominiczak, AF, Junor, BJR, Briggs, JD, and Moss, JG (1997) Effect of renal-artery stenting on progression of renovascular renal failure. Lancet, 349 (9059). pp. 1133-1136.

MacLeod, M, Taylor, AD, Baxter, G, Harden, P, Briggs, D, Moss, J, Semple, PF, Connell, J, and Dominiczak, AF (1995) Renal artery stenosis managed by Palmaz stent insertion: Technical and clinical outcome. Journal of Hypertension, 13 (12). pp. 1791-1795.

MacLeod, MJ, Connell, J, Harden, PN, Briggs, JD, Moss, J, and Dominiczak, AF (1995) Transluminal Vascular Stents for Ostial Atherosclerotic Renal-Artery Stenosis. Lancet, 346 (8982). pp. 1109-1110.

Oconnell, JE, Dominiczak, AF, Isles, CG, Mclellan, AR, Davidson, G, Gray, CE, and Connell, J (1990) A Comparison of Calcium Pentagastrin and Trh Tests in Screening for Medullary Carcinoma of the Thyroid in Men-Iia. Clinical Endocrinology, 32 (4). pp. 417-421.

Hastie, C., Sloan, W., Dominiczak, A., Morrison, D., and Padmanabhan, S. Long-term and ultra long-term blood pressure variability during follow-up and mortality in 14 522 patients with hypertension. Hypertension . ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.113.01343) (In Press)

Book Section

Miller, W.H., Nicklin, S.A., Baker, A.H., and Dominiczak, A. (2005) Gene transfer and the cardiovascular system. In: Raizada, M.K., Paton, J.F.R., Kasparov, S. and Katovich, M.J. (eds.) Cardiovascular Genomics. Series: Contemporary cardiology . Humana Press, Totowa, NJ, USA, pp. 175-196. ISBN 9781588294005

Conference Proceedings

Sinnott, R.O. et al. (2004) Grid services supporting the usage of secure federated, distributed biomedical data. In: Proceedings of UK e-Science All Hands Meeting, 31 Aug - 3 Sept 2004, Nottingham, UK.