Dr Stephen Tait

  • Senior Lecturer (Institute of Cancer Sciences)

telephone: 01413308703
email: Stephen.Tait@glasgow.ac.uk

Research interests

Mitochondria and Cell Death ‎‎

Cell death is a key tumour suppressor mechanism that must be inhibited in order for cancer to develop. Sensitivity to cell death also governs therapeutic efficacy because anti-cancer therapies often act by killing cells. The major form of programmed cell death is apoptosis, a process in which mitochondria play an essential role. Our research focuses upon understanding how mitochondria control cell death and addressing how this is deregulated in cancer. Clinical translation of our findings should lead to improvements of existing therapies and development of new approaches to enable tumour selective killing.

 

 

 

Figure 1

Visualising the distinct steps of apoptosis. HeLa cells expressing YFP-Bax and Smac 1–60 mCherry were induced to undergo apoptosis (Trail plus ABT-737). Images of the same cells are shown, progressing in time, left to right. Following activation, YFP-Bax translocates to the mitochondria and MOMP occurs, detected by redistribution of Smac 1–60 mCherry throughout the cell. Caspase activity now ensues leading to typical apoptotic characteristics: cell shrinkage, nuclear condensation (blue) and phosphatidylserine relocalisation to the outer leaflet of the plasma membrane (detected by Annexin V APC binding, violet).

Link to research page in the Beatson Institute

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Targeting MCL-1 in breast cancer
    Breast Cancer Now
    2016 - 2019
     
  • Apoptosis as an oncogenic process: understanding and exploiting its dark-side
    Cancer Research UK
    2015 - 2018
     
  • ISSF Catalyst: Identification of mechanism(s) of acquired drug resistance in CML using a genome-scale CRISPR-knockout screening approach
    Wellcome Trust
    2015 - 2016
     
  • University Research Fellowship
    Royal Society
    2015 - 2016
     
  • Understanding and preventing resistance to cell-killing anti-cancer drugs
    Tenovus-Scotland
    2015 - 2016
     
  • University Research Fellowship
    Royal Society
    2014 - 2015
     
  • A new approach to understanding mitochondrial functions in cell death, autophagy and beyond
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Mitochondrial regulation of cell death
    European Commission
    2012 - 2016
     
  • University Research Fellowship
    Royal Society
    2012 - 2016
     

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004 | 2002 | 2000
Number of items: 43.

2016

Ichim, G., and Tait, S. W.G. (2016) A fate worse than death: apoptosis as an oncogenic process. Nature Reviews Cancer, (doi:10.1038/nrc.2016.58) (PMID:27364482) (Early Online Publication)

Riley, J. S., and Tait, S. W.G. (2016) Mechanisms of mitophagy: putting the powerhouse into the doghouse. Biological Chemistry, 397(7), pp. 617-635. (doi:10.1515/hsz-2016-0137) (PMID:27071149)

Correia-Melo, C. et al. (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal, 35, pp. 724-742. (doi:10.15252/embj.201592862) (PMID:26848154)

Giampazolias, E., and Tait, S. W.G. (2016) Mitochondria and the hallmarks of cancer. FEBS Journal, 283(5), pp. 803-814. (doi:10.1111/febs.13603) (PMID:26607558)

Lopez, J. et al. (2016) Mito-priming as a method of engineered Bcl-2 addiction. Nature Communications, 7, 10538. (doi:10.1038/ncomms10538) (PMID:26833356) (PMCID:PMC4740867)

2015

Ichim, G. et al. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Molecular Cell, 57(5), pp. 860-872. (doi:10.1016/j.molcel.2015.01.018) (PMID:25702873) (PMCID:PMC4352766)

Baudot, A., Haller, M., Mrschtik, M., Tait, S., and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi:10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Lopez, J., and Tait, S. (2015) Mitochondrial apoptosis: killing cancer using the enemy within. British Journal of Cancer, 112(6), pp. 957-962. (doi:10.1038/bjc.2015.85) (PMID:25742467) (PMCID:PMC4366906)

Todt, F. et al. (2015) Differential retrotranslocation of mitochondrial Bax and Bak. EMBO Journal, 34(1), pp. 67-80. (doi:10.15252/embj.201488806)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi:10.1016/j.celrep.2015.07.055) (PMID:26299965)

Galluzzi, L. et al. (2015) Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation, 22(1), pp. 58-73. (doi:10.1038/cdd.2014.137)

2014

Lopez, J., and Tait, S. W.G. (2014) Killing the killer: PARC/CUL9 promotes cell survival by destroying Cytochrome c. Science Signaling, 7(334), pe17-pe17. (doi:10.1126/scisignal.2005619)

Tait, S. W. G., Ichim, G., and Green, D. R. (2014) Die another way - non-apoptotic mechanisms of cell death. Journal of Cell Science, 127(10), pp. 2135-2144. (doi:10.1242/jcs.093575)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M., Vousden, K. H., and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi:10.4161/15548627.2014.981914) (PMID:25629932)

Orozco, S., Yatim, N., Werner, M.R., Tran, H., Gunja, S.Y., Tait, S.W.G., Albert, M.L., Green, D.R., and Oberst, A. (2014) RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death and Differentiation, 21(10), pp. 1511-1521. (doi:10.1038/cdd.2014.76)

2013

Tait, S.W.G. et al. (2013) Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Reports, 5(4), pp. 878-885. (doi:10.1016/j.celrep.2013.10.034)

Tait, S. (2013) DNA: leukemia's secret weapon of bone mass destruction. Oncogene, 32(44), pp. 5199-5200. (doi:10.1038/onc.2012.639)

Tait, S.W.T., and Green, D.R. (2013) Mitochondrial regulation of cell death. Cold Spring Harbor Perspectives in Biology, 5(9), a008706. (doi:10.1101/cshperspect.a008706)

2012

Bender, C.E., Fitzgerald, P., Tait, S.W.G., Llambi, F., McStay, G.P., Tupper, D.O., Pellettieri, J., Alvarado, A.S., Salvesen, G.S., and Green, D.R. (2012) Mitochondrial pathway of apoptosis is ancestral in metazoans. Proceedings of the National Academy of Sciences of the United States of America, 109(13), pp. 4904-4909. (doi:10.1073/pnas.1120680109)

Tait, S.W.G., and Green, D.R. (2012) Mitochondria and cell signalling. Journal of Cell Science, 125(4), pp. 807-815. (doi:10.1242/​jcs.099234)

2011

Anand, P.K., Tait, S.W.G., Lamkanfi, M., Amer, A.O., Nunez, G., Pages, G., Pouyssegur, J., McGargill, M.A., Green, D.R., and Kanneganti, T.-D. (2011) TLR2 and RIP2 pathways mediate autophagy of listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. Journal of Biological Chemistry, 286(50), pp. 42981-42991. (doi:10.1074/jbc.M111.310599)

Llambi, F., Moldoveanu, T., Tait, S.W.G., Bouchier-Hayes, L., Temirov, J., McCormick, L.L., Dillon, C.P., and Green, D.R. (2011) A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Molecular Cell, 44(4), pp. 517-531. (doi:10.1016/j.molcel.2011.10.001)

Maas, C., de Vries, E., Tait, S.W.G., and Borst, J. (2011) Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53. Oncogene, 30(33), pp. 3636-3647. (doi:10.1038/onc.2011.75)

Niemi, N.M. et al. (2011) MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Molecular and Cellular Biology, 31(7), pp. 1357-1368. (doi:10.1128/​MCB.00788-10)

Taherbhoy, A.M. et al. (2011) Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Molecular Cell, 44(3), pp. 451-461. (doi:10.1016/j.molcel.2011.08.034)

2010

Caro-Maldonado, A., Tait, S.W.G., Ramírez-Peinado, S., Ricci, J.-E., Fabregat, I., Green, D.R., and Muñoz-Pinedo, C. (2010) Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death and Differentiation, 17(8), pp. 1335-1344. (doi:10.1038/cdd.2010.21)

Maas, C., Verbrugge, I., de Vries, E., Savich, G., van de Kooij, L.W., Tait, S.W.G., and Borst, J. (2010) Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation. Cell Death and Differentiation, 17(10), pp. 1613-1623. (doi:10.1038/cdd.2010.39)

Tait, S.W.G., and Green, D.R. (2010) Cell survival in tough times: the mitochondrial recovery plan. Cell Cycle, 9(21), pp. 4254-4255. (doi:10.4161/cc.9.21.13962)

Tait, S.W.G., and Green, D.R. (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nature Reviews Molecular Cell Biology, 11(9), pp. 621-632. (doi:10.1038/nrm2952)

Tait, S.W.G., Parsons, M.J., Llambi, F., Bouchier-Hayes, L., Connell, S., Muñoz-Pinedo, C., and Green, D.R. (2010) Resistance to caspase-independent cell death requires persistence of intact mitochondria. Developmental Cell, 18(5), pp. 802-813. (doi:10.1016/j.devcel.2010.03.014)

2009

Tait, S.W.G., Bouchier-Hayes, L., Oberst, A., Connell, S., and Green, D.R. (2009) Live to dead cell imaging. Methods in Molecular Biology, 559(1), pp. 33-48. (doi:10.1007/978-1-60327-017-5_3)

2008

Tait, S.W.G., and Green, D.R. (2008) Caspase-independent cell death: leaving the set without the final cut. Oncogene, 27(50), pp. 6452-6461. (doi:10.1038/onc.2008.311)

Verbrugge, I., de Vries, E., Tait, S.W.G., Wissink, E.H.J., Walczak, H., Verheij, M., and Borst, J. (2008) Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene, 27(5), pp. 574-584. (doi:10.1038/sj.onc.1210696)

2007

Colell, A. et al. (2007) GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell, 129(5), pp. 983-997. (doi:10.1016/j.cell.2007.03.045)

Sanjuan, M.A. et al. (2007) Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature, 450(7173), pp. 1253-1257. (doi:10.1038/nature06421)

Tait, S.W.G., de Vries, E., Maas, C., Keller, A.M., D'Santos, C.S., and Borst, J. (2007) Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. Journal of Cell Biology, 179(7), pp. 1453-1466. (doi:10.1083/jcb.200707063)

2006

Ortiz-Ferrón, G., Tait, S.W.G., Robledo, G., de Vries, E., Borst, J., and López-Rivas, A. (2006) The mitogen-activated protein kinase pathway can inhibit TRAIL-induced apoptosis by prohibiting association of truncated Bid with mitochondria. Cell Death and Differentiation, 13(11), pp. 1857-1865. (doi:10.1038/sj.cdd.4401875)

2004

Danen-van Oorschot, A.A.A.M., Voskamp, P., Seelen, M.C.M.J., van Miltenburg, M.H.A.M., Bolk, M.W., Tait, S.W.G., Boesen-de Cock, J.G.R., Rohn, J.L., Borst, J., and Noteborn, M.H.M. (2004) Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. Cell Death and Differentiation, 11(5), pp. 564-573. (doi:10.1038/sj.cdd.4401391)

Tait, S.W.G., Werner, A.B., de Vries, E., and Borst, J. (2004) Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability. Cell Death and Differentiation, 11(8), pp. 800-811. (doi:10.1038/sj.cdd.4401410)

Werner, A.B., Tait, S.W.G., de Vries, E., Eldering, E., and Borst, J. (2004) Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. Journal of Biological Chemistry, 279(27), pp. 28771-28780. (doi:10.1074/jbc.M400268200)

2002

Werner, A.B., de Vries, E., Tait, S.W.G., Bontjer, I., and Borst, J. (2002) Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic Bak or Bax. Journal of Biological Chemistry, 277(25), pp. 22781-22788. (doi:10.1074/jbc.M201469200)

Werner, A.B., de Vries, E., Tait, S.W.G., Bontjer, I., and Borst, J. (2002) TRAIL receptor and CD95 signal to mitochondria via FADD, Caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid. Journal of Biological Chemistry, 277(43), pp. 40760-40767. (doi:10.1074/jbc.M204351200)

2000

Tait, S.W.G. (2000) Mechanism of inactivation of NF-κΒ by a viral homologue of ΙκΒα. Signal-induced release of ΙκΒα results in the binding of the viral homologue to NF-κΒ. Journal of Biological Chemistry, 275(44), pp. 34656-34664. (doi:10.1074/jbc.M000320200)

This list was generated on Wed Jul 27 12:19:47 2016 BST.
Jump to: Articles
Number of items: 43.

Articles

Ichim, G., and Tait, S. W.G. (2016) A fate worse than death: apoptosis as an oncogenic process. Nature Reviews Cancer, (doi:10.1038/nrc.2016.58) (PMID:27364482) (Early Online Publication)

Riley, J. S., and Tait, S. W.G. (2016) Mechanisms of mitophagy: putting the powerhouse into the doghouse. Biological Chemistry, 397(7), pp. 617-635. (doi:10.1515/hsz-2016-0137) (PMID:27071149)

Correia-Melo, C. et al. (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal, 35, pp. 724-742. (doi:10.15252/embj.201592862) (PMID:26848154)

Giampazolias, E., and Tait, S. W.G. (2016) Mitochondria and the hallmarks of cancer. FEBS Journal, 283(5), pp. 803-814. (doi:10.1111/febs.13603) (PMID:26607558)

Lopez, J. et al. (2016) Mito-priming as a method of engineered Bcl-2 addiction. Nature Communications, 7, 10538. (doi:10.1038/ncomms10538) (PMID:26833356) (PMCID:PMC4740867)

Ichim, G. et al. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Molecular Cell, 57(5), pp. 860-872. (doi:10.1016/j.molcel.2015.01.018) (PMID:25702873) (PMCID:PMC4352766)

Baudot, A., Haller, M., Mrschtik, M., Tait, S., and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi:10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Lopez, J., and Tait, S. (2015) Mitochondrial apoptosis: killing cancer using the enemy within. British Journal of Cancer, 112(6), pp. 957-962. (doi:10.1038/bjc.2015.85) (PMID:25742467) (PMCID:PMC4366906)

Todt, F. et al. (2015) Differential retrotranslocation of mitochondrial Bax and Bak. EMBO Journal, 34(1), pp. 67-80. (doi:10.15252/embj.201488806)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi:10.1016/j.celrep.2015.07.055) (PMID:26299965)

Galluzzi, L. et al. (2015) Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation, 22(1), pp. 58-73. (doi:10.1038/cdd.2014.137)

Lopez, J., and Tait, S. W.G. (2014) Killing the killer: PARC/CUL9 promotes cell survival by destroying Cytochrome c. Science Signaling, 7(334), pe17-pe17. (doi:10.1126/scisignal.2005619)

Tait, S. W. G., Ichim, G., and Green, D. R. (2014) Die another way - non-apoptotic mechanisms of cell death. Journal of Cell Science, 127(10), pp. 2135-2144. (doi:10.1242/jcs.093575)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M., Vousden, K. H., and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi:10.4161/15548627.2014.981914) (PMID:25629932)

Orozco, S., Yatim, N., Werner, M.R., Tran, H., Gunja, S.Y., Tait, S.W.G., Albert, M.L., Green, D.R., and Oberst, A. (2014) RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death and Differentiation, 21(10), pp. 1511-1521. (doi:10.1038/cdd.2014.76)

Tait, S.W.G. et al. (2013) Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Reports, 5(4), pp. 878-885. (doi:10.1016/j.celrep.2013.10.034)

Tait, S. (2013) DNA: leukemia's secret weapon of bone mass destruction. Oncogene, 32(44), pp. 5199-5200. (doi:10.1038/onc.2012.639)

Tait, S.W.T., and Green, D.R. (2013) Mitochondrial regulation of cell death. Cold Spring Harbor Perspectives in Biology, 5(9), a008706. (doi:10.1101/cshperspect.a008706)

Bender, C.E., Fitzgerald, P., Tait, S.W.G., Llambi, F., McStay, G.P., Tupper, D.O., Pellettieri, J., Alvarado, A.S., Salvesen, G.S., and Green, D.R. (2012) Mitochondrial pathway of apoptosis is ancestral in metazoans. Proceedings of the National Academy of Sciences of the United States of America, 109(13), pp. 4904-4909. (doi:10.1073/pnas.1120680109)

Tait, S.W.G., and Green, D.R. (2012) Mitochondria and cell signalling. Journal of Cell Science, 125(4), pp. 807-815. (doi:10.1242/​jcs.099234)

Anand, P.K., Tait, S.W.G., Lamkanfi, M., Amer, A.O., Nunez, G., Pages, G., Pouyssegur, J., McGargill, M.A., Green, D.R., and Kanneganti, T.-D. (2011) TLR2 and RIP2 pathways mediate autophagy of listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. Journal of Biological Chemistry, 286(50), pp. 42981-42991. (doi:10.1074/jbc.M111.310599)

Llambi, F., Moldoveanu, T., Tait, S.W.G., Bouchier-Hayes, L., Temirov, J., McCormick, L.L., Dillon, C.P., and Green, D.R. (2011) A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Molecular Cell, 44(4), pp. 517-531. (doi:10.1016/j.molcel.2011.10.001)

Maas, C., de Vries, E., Tait, S.W.G., and Borst, J. (2011) Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53. Oncogene, 30(33), pp. 3636-3647. (doi:10.1038/onc.2011.75)

Niemi, N.M. et al. (2011) MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Molecular and Cellular Biology, 31(7), pp. 1357-1368. (doi:10.1128/​MCB.00788-10)

Taherbhoy, A.M. et al. (2011) Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Molecular Cell, 44(3), pp. 451-461. (doi:10.1016/j.molcel.2011.08.034)

Caro-Maldonado, A., Tait, S.W.G., Ramírez-Peinado, S., Ricci, J.-E., Fabregat, I., Green, D.R., and Muñoz-Pinedo, C. (2010) Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death and Differentiation, 17(8), pp. 1335-1344. (doi:10.1038/cdd.2010.21)

Maas, C., Verbrugge, I., de Vries, E., Savich, G., van de Kooij, L.W., Tait, S.W.G., and Borst, J. (2010) Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation. Cell Death and Differentiation, 17(10), pp. 1613-1623. (doi:10.1038/cdd.2010.39)

Tait, S.W.G., and Green, D.R. (2010) Cell survival in tough times: the mitochondrial recovery plan. Cell Cycle, 9(21), pp. 4254-4255. (doi:10.4161/cc.9.21.13962)

Tait, S.W.G., and Green, D.R. (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nature Reviews Molecular Cell Biology, 11(9), pp. 621-632. (doi:10.1038/nrm2952)

Tait, S.W.G., Parsons, M.J., Llambi, F., Bouchier-Hayes, L., Connell, S., Muñoz-Pinedo, C., and Green, D.R. (2010) Resistance to caspase-independent cell death requires persistence of intact mitochondria. Developmental Cell, 18(5), pp. 802-813. (doi:10.1016/j.devcel.2010.03.014)

Tait, S.W.G., Bouchier-Hayes, L., Oberst, A., Connell, S., and Green, D.R. (2009) Live to dead cell imaging. Methods in Molecular Biology, 559(1), pp. 33-48. (doi:10.1007/978-1-60327-017-5_3)

Tait, S.W.G., and Green, D.R. (2008) Caspase-independent cell death: leaving the set without the final cut. Oncogene, 27(50), pp. 6452-6461. (doi:10.1038/onc.2008.311)

Verbrugge, I., de Vries, E., Tait, S.W.G., Wissink, E.H.J., Walczak, H., Verheij, M., and Borst, J. (2008) Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene, 27(5), pp. 574-584. (doi:10.1038/sj.onc.1210696)

Colell, A. et al. (2007) GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell, 129(5), pp. 983-997. (doi:10.1016/j.cell.2007.03.045)

Sanjuan, M.A. et al. (2007) Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature, 450(7173), pp. 1253-1257. (doi:10.1038/nature06421)

Tait, S.W.G., de Vries, E., Maas, C., Keller, A.M., D'Santos, C.S., and Borst, J. (2007) Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. Journal of Cell Biology, 179(7), pp. 1453-1466. (doi:10.1083/jcb.200707063)

Ortiz-Ferrón, G., Tait, S.W.G., Robledo, G., de Vries, E., Borst, J., and López-Rivas, A. (2006) The mitogen-activated protein kinase pathway can inhibit TRAIL-induced apoptosis by prohibiting association of truncated Bid with mitochondria. Cell Death and Differentiation, 13(11), pp. 1857-1865. (doi:10.1038/sj.cdd.4401875)

Danen-van Oorschot, A.A.A.M., Voskamp, P., Seelen, M.C.M.J., van Miltenburg, M.H.A.M., Bolk, M.W., Tait, S.W.G., Boesen-de Cock, J.G.R., Rohn, J.L., Borst, J., and Noteborn, M.H.M. (2004) Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. Cell Death and Differentiation, 11(5), pp. 564-573. (doi:10.1038/sj.cdd.4401391)

Tait, S.W.G., Werner, A.B., de Vries, E., and Borst, J. (2004) Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability. Cell Death and Differentiation, 11(8), pp. 800-811. (doi:10.1038/sj.cdd.4401410)

Werner, A.B., Tait, S.W.G., de Vries, E., Eldering, E., and Borst, J. (2004) Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. Journal of Biological Chemistry, 279(27), pp. 28771-28780. (doi:10.1074/jbc.M400268200)

Werner, A.B., de Vries, E., Tait, S.W.G., Bontjer, I., and Borst, J. (2002) Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic Bak or Bax. Journal of Biological Chemistry, 277(25), pp. 22781-22788. (doi:10.1074/jbc.M201469200)

Werner, A.B., de Vries, E., Tait, S.W.G., Bontjer, I., and Borst, J. (2002) TRAIL receptor and CD95 signal to mitochondria via FADD, Caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid. Journal of Biological Chemistry, 277(43), pp. 40760-40767. (doi:10.1074/jbc.M204351200)

Tait, S.W.G. (2000) Mechanism of inactivation of NF-κΒ by a viral homologue of ΙκΒα. Signal-induced release of ΙκΒα results in the binding of the viral homologue to NF-κΒ. Journal of Biological Chemistry, 275(44), pp. 34656-34664. (doi:10.1074/jbc.M000320200)

This list was generated on Wed Jul 27 12:19:47 2016 BST.