2014

Bilsland, A. E. , Stevenson, K., Liu, Y., Hoare, S., Cairney, C. J., Roffey, J. and Keith, W. N. (2014) Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. PLoS Computational Biology, 10(2), e1003448. (doi: 10.1371/journal.pcbi.1003448) (PMID:24550717) (PMCID:PMC3923661)

2012

Venturini, L., Daidone, M.G., Motta, R., Cimino-Reale, G., Hoare, S.F., Gronchi, A., Folini, M., Keith, W.N. and Zaffaroni, N. (2012) Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance. Neuro-Oncology, 14(6), pp. 736-744. (doi: 10.1093/neuonc/nos083)

2011

Soo, J.K. et al. (2011) Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression. Pigment Cell and Melanoma Research, 24(3), pp. 490-503. (doi: 10.1111/j.1755-148X.2011.00850.x)

2010

Lafferty-Whyte, K., Bilsland, A. , Hoare, S.F., Burns, S., Zaffaroni, N., Cairney, C.J. and Keith, W.N. (2010) TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. Neoplasia, 12(5), pp. 405-414.

2009

Bilsland, A.E., Hoare, S.F., Stevenson, K.H., Plumb, J.A., Gomez-Roman, N. , Cairney, C.J., Burns, S., Lafferty-Whyte, K., Hammonds, T. and Keith, W.N. (2009) Dynamic telomerase gene suppression via network effects of GSK3 inhibition. PLoS ONE, 4(7), e6459. (doi: 10.1371/journal.pone.0006459)

Zhang, X. et al. (2009) A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. Journal of Cell Biology, 184(1), pp. 67-82. (doi: 10.1083/jcb.200801009)

2008

Cairney, C., Hoare, S., Daidone, M., Zaffaroni, N. and Keith, W. (2008) High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma. British Journal of Cancer, 98(8), pp. 1467-1474. (doi: 10.1038/sj.bjc.6604328)

Saretzki, G. et al. (2008) Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells, 26(2), pp. 455-464. (doi: 10.1634/stemcells.2007-0628)

2006

Anderson, C.J., Hoare, S.F., Ashcroft, M., Bilsland, A.E. and Keith, W.N. (2006) Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms. Oncogene, 25(1), pp. 61-69. (doi: 10.1038/sj.onc.1209011)

Serakinci, N., Hoare, S.F., Kassem, M., Atkinson, S.P. and Keith, W.N. (2006) Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell. Regenerative Medicine, 1(1), pp. 125-131. (doi: 10.2217/17460781.1.1.125)

2005

Atkinson, S.P., Hoare, S.F., Glasspool, R.M. and Keith, W.N. (2005) Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters. Cancer Research, 65(17), pp. 7585-7590. (doi: 10.1158/0008-5472.CAN-05-1715)

Drummond, M.W., Hoare, S.F., Monaghan, A., Graham, S.M., Alcorn, M.J., Keith, W.N. and Holyoake, T.L. (2005) Dysregulated expression of the major telomerase components in leukaemic stem cells. Leukemia, 19(3), pp. 381-389. (doi: 10.1038/sj.leu.2403616)

Glasspool, R.M., Burns, S., Hoare, S.F., Svensson, C. and Keith, W.N. (2005) The hTERT and hTERC telomerase gene promoters are activated by the second Exon of the adenoviral protein, E1A, identifying the transcriptional co-repressor CtBP as a potential repressor of both genes. Neoplasia, 7(6), pp. 614-622. (doi: 10.1593/neo.04766)

2004

Keith, W.N. and Hoare, S.F. (2004) Detection of telomerase hTERT gene expression and its splice variants by RT-PCR. In: Roulston, J.E. and Bartlett, J.M.S. (eds.) Molecular Diagnosis of Cancer: Methods and Protocols. Series: Methods in molecular medicine (97). Humana Press: Totowa, NJ, USA, pp. 297-309. ISBN 9781588291608

2003

Madhusudan, S. et al. (2003) A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer. British Journal of Cancer, 89, pp. 1418-1422. (doi: 10.1038/sj.bjc.6601321)

Zhao, J.Q., Bilsland, A. , Hoare, S.F. and Keith, W.N. (2003) Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene. FEBS Letters, 536(1-3), pp. 111-119. (doi: 10.1016/S0014-5793(03)00038-3)

2001

Hoare, S.F., Bryce, L.A., Wisman, G.B.A., Burns, S., Going, J.J., van der Zee, A.G.J. and Keith, W.N. (2001) Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter. Cancer Research, 61(1), pp. 27-32.

2000

Bryce, L.A., Morrison, N., Hoare, S.F., Muir, S. and Keith, W.N. (2000) Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia, 2(3), pp. 197-201.

Zhao, J.Q., Glasspool, R.M., Hoare, S.F., Bilsland, A. , Szatmari, I. and Keith, W.N. (2000) Activation of telomerase RNA gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3. Neoplasia, 2(6), pp. 531-539.

1998

Zhao, J.Q., Hoare, S.F., McFarlane, R., Muir, S., Parkinson, E.K., Black, D.M. and Keith, W.N. (1998) Cloning and characterization of human and mouse telomerase RNA gene promoter sequences. Oncogene, 16(10), pp. 1345-1350.

1997

Hoare, S.F., Freeman, C.A., Coutts, J.C., Varley, J.M., James, L. and Keith, W.N. (1997) Identification of genetic changes associated with drug resistance by reverse in situ hybridization. British Journal of Cancer, 75(2), pp. 275-282.

Soder, A.I., Hoare, S.F., Muir, S., Going, J.J., Parkinson, E.K. and Keith, W.N. (1997) Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene, 14(9), pp. 1013-1021.

Soder, A.I., Hoare, S.F., Muire, S., Balmain, A., Parkinson, E.K. and Keith, W.N. (1997) Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting. Genomics, 41(2), pp. 293-294. (doi: 10.1006/geno.1997.4621)

Articles

Bilsland, A. E. , Stevenson, K., Liu, Y., Hoare, S., Cairney, C. J., Roffey, J. and Keith, W. N. (2014) Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. PLoS Computational Biology, 10(2), e1003448. (doi: 10.1371/journal.pcbi.1003448) (PMID:24550717) (PMCID:PMC3923661)

Venturini, L., Daidone, M.G., Motta, R., Cimino-Reale, G., Hoare, S.F., Gronchi, A., Folini, M., Keith, W.N. and Zaffaroni, N. (2012) Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance. Neuro-Oncology, 14(6), pp. 736-744. (doi: 10.1093/neuonc/nos083)

Soo, J.K. et al. (2011) Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression. Pigment Cell and Melanoma Research, 24(3), pp. 490-503. (doi: 10.1111/j.1755-148X.2011.00850.x)

Lafferty-Whyte, K., Bilsland, A. , Hoare, S.F., Burns, S., Zaffaroni, N., Cairney, C.J. and Keith, W.N. (2010) TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. Neoplasia, 12(5), pp. 405-414.

Bilsland, A.E., Hoare, S.F., Stevenson, K.H., Plumb, J.A., Gomez-Roman, N. , Cairney, C.J., Burns, S., Lafferty-Whyte, K., Hammonds, T. and Keith, W.N. (2009) Dynamic telomerase gene suppression via network effects of GSK3 inhibition. PLoS ONE, 4(7), e6459. (doi: 10.1371/journal.pone.0006459)

Zhang, X. et al. (2009) A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. Journal of Cell Biology, 184(1), pp. 67-82. (doi: 10.1083/jcb.200801009)

Cairney, C., Hoare, S., Daidone, M., Zaffaroni, N. and Keith, W. (2008) High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma. British Journal of Cancer, 98(8), pp. 1467-1474. (doi: 10.1038/sj.bjc.6604328)

Saretzki, G. et al. (2008) Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells, 26(2), pp. 455-464. (doi: 10.1634/stemcells.2007-0628)

Anderson, C.J., Hoare, S.F., Ashcroft, M., Bilsland, A.E. and Keith, W.N. (2006) Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms. Oncogene, 25(1), pp. 61-69. (doi: 10.1038/sj.onc.1209011)

Serakinci, N., Hoare, S.F., Kassem, M., Atkinson, S.P. and Keith, W.N. (2006) Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell. Regenerative Medicine, 1(1), pp. 125-131. (doi: 10.2217/17460781.1.1.125)

Atkinson, S.P., Hoare, S.F., Glasspool, R.M. and Keith, W.N. (2005) Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters. Cancer Research, 65(17), pp. 7585-7590. (doi: 10.1158/0008-5472.CAN-05-1715)

Drummond, M.W., Hoare, S.F., Monaghan, A., Graham, S.M., Alcorn, M.J., Keith, W.N. and Holyoake, T.L. (2005) Dysregulated expression of the major telomerase components in leukaemic stem cells. Leukemia, 19(3), pp. 381-389. (doi: 10.1038/sj.leu.2403616)

Glasspool, R.M., Burns, S., Hoare, S.F., Svensson, C. and Keith, W.N. (2005) The hTERT and hTERC telomerase gene promoters are activated by the second Exon of the adenoviral protein, E1A, identifying the transcriptional co-repressor CtBP as a potential repressor of both genes. Neoplasia, 7(6), pp. 614-622. (doi: 10.1593/neo.04766)

Madhusudan, S. et al. (2003) A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer. British Journal of Cancer, 89, pp. 1418-1422. (doi: 10.1038/sj.bjc.6601321)

Zhao, J.Q., Bilsland, A. , Hoare, S.F. and Keith, W.N. (2003) Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene. FEBS Letters, 536(1-3), pp. 111-119. (doi: 10.1016/S0014-5793(03)00038-3)

Hoare, S.F., Bryce, L.A., Wisman, G.B.A., Burns, S., Going, J.J., van der Zee, A.G.J. and Keith, W.N. (2001) Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter. Cancer Research, 61(1), pp. 27-32.

Bryce, L.A., Morrison, N., Hoare, S.F., Muir, S. and Keith, W.N. (2000) Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia, 2(3), pp. 197-201.

Zhao, J.Q., Glasspool, R.M., Hoare, S.F., Bilsland, A. , Szatmari, I. and Keith, W.N. (2000) Activation of telomerase RNA gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3. Neoplasia, 2(6), pp. 531-539.

Zhao, J.Q., Hoare, S.F., McFarlane, R., Muir, S., Parkinson, E.K., Black, D.M. and Keith, W.N. (1998) Cloning and characterization of human and mouse telomerase RNA gene promoter sequences. Oncogene, 16(10), pp. 1345-1350.

Hoare, S.F., Freeman, C.A., Coutts, J.C., Varley, J.M., James, L. and Keith, W.N. (1997) Identification of genetic changes associated with drug resistance by reverse in situ hybridization. British Journal of Cancer, 75(2), pp. 275-282.

Soder, A.I., Hoare, S.F., Muir, S., Going, J.J., Parkinson, E.K. and Keith, W.N. (1997) Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene, 14(9), pp. 1013-1021.

Soder, A.I., Hoare, S.F., Muire, S., Balmain, A., Parkinson, E.K. and Keith, W.N. (1997) Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting. Genomics, 41(2), pp. 293-294. (doi: 10.1006/geno.1997.4621)

Book Sections

Keith, W.N. and Hoare, S.F. (2004) Detection of telomerase hTERT gene expression and its splice variants by RT-PCR. In: Roulston, J.E. and Bartlett, J.M.S. (eds.) Molecular Diagnosis of Cancer: Methods and Protocols. Series: Methods in molecular medicine (97). Humana Press: Totowa, NJ, USA, pp. 297-309. ISBN 9781588291608