Professor Mhairi Copland

  • Professor of Translational Haematology (Paul O'Gorman Leukaemia Research Centre)

telephone: 01413017872
email: Mhairi.Copland@glasgow.ac.uk

Research interests

The Leukaemia Stem Cell Self-Renewal group was established in 2008. Our research group is interested in the abnormalities of stem cell self-renewal and bone marrow microenvironment which develop in myeloid leukaemias. We have specific interests in the Hedgehog pathway in myeloid leukaemias, quiescence as a mechanism of drug resistance in leukaemia stem cells and interactions between leukaemia stem cells and their niche, in particular via the CXCL12/CXCR4 axis. An important aim of our work is the translation of basic laboratory research to clinical trials which we have achieved with the use of Hedgehog pathway inhibitors in chronic myeloid leukaemia.

Research interests

Aberrant leukaemia stem cell self-renewal and altered bone marrow microenvironment or “niche” allows the leukaemia stem cells to survive the most effective chemotherapeutic strategies available today, resulting in refractory leukaemia or relapse. Small molecule inhibitors are increasingly becoming available to target these essential stem cell pathways and assessing these novel compounds forms a very important part of our research.

We use a combination of immunomagentic cell separation and multi-parameter fluorescence activated cell sorting (FACS) to isolate the most primitive haemopoietic stem cells from the progenitor cells in both normal and leukaemic primary samples. We then use a combination of long and short-term culture techniques, together with a number of gene expression (microarray, Taqman qRT-PCR, Fluidigm) and protein expression/activity (Western blotting, flow cytometry, immunofluorescence) approaches to assess the differences between normal and leukaemic cells and the effects of small molecule inhibitors. In addition, we are currently involved with extending the leukaemia Biobank to include samples from patients with acute leukaemia and myelodysplastic syndrome.

We work with several academic collaborators including: Professor Peter Adams (Glasgow), Dr David Vetrie (Glasgow), Professor Richard Clark (Liverpool), Professor Paresh Vyas (Oxford), Professor Tim Bruemmendorf (Aachen), Professor Tomasz Skorski (Temple) and Professor Ravi Bhatia (Duarte).

Individual projects:

• Identification and preclinical studies of novel therapeutic strategies to eliminate leukaemia stem cells

• Determining the role of Hedgehog signalling in conferring chemoresistance in myeloid malignancies

• Hedgehog signalling as a leukaemia stem cell self-renewal pathway in CML

• The importance of the Notch signalling pathway and its interactions in the maintenance and progression of chronic myeloid leukaemia

• Antagonising the CXCR4/SDF-1 interaction in chronic myeloid leukaemia for sensitisation to tyrosine kinase inhibitors

• Characterisation and therapeutic targeting of cancer stem cells in blast phase chronic myeloid leukaemia

• Investigating the properties of residual leukaemia cells, including leukaemia stem cells, in optimally responding chronic myeloid leukaemia patients  

My clinical areas of interest/expertise are stem cell transplantation and myeloid leukaemias. I have an active role as a Principal Investigator (PI) for clinical trials at the Beatson West of Scotland Cancer Centre and I am PI for the Leukaemia and Lymphoma Research Therapy Acceleration Programme here in Glasgow.  

Group Members

• Dr Ross Kinstrie (PDRA)

• Miss Heather Morrison (RA – shared with Dr Helen Wheadon)

• Dr David Irvine (Clinical Lecturer)

• Dr Victoria Campbell (STMTI Clinical Research Fellow – jointly supervised with Dr Helen Wheadon)

• Dr Susan Rhodes (CSO Clinical Research Fellow – jointly supervised with Dr Helen Wheadon)

• Dr Annie Latif (CR-UK Clinical Research Fellow - jointly supervised with Professor Peter Adams)

• Dr Gillian Horne (Wellcome Trust Clinical Research Fellow)

• Miss Parto Toofan (NC3Rs PhD candidate - jointly supervised with Dr Helen Wheadon)

• Mr Christopher Estell (PhD candidate - jointly supervised with Dr Helen Wheadon)

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Glasgow ECMC
    Scottish Executive Health Department
    2017 - 2018
     
  • Glasgow ECMC
    Cancer Research UK
    2017 - 2018
     
  • Leukaemia and Lymphoma Research Therapy Acceleration Programme
    Bloodwise
    2017 - 2019
     
  • ISSF Catalyst: Identification & validation of downstream targets of the histone demethylase KDM4A(JMJD2A) in Acute Myeloid Leukaemia (AML)
    Wellcome Trust
    2015 - 2016
     
  • Targeting p53, cMyc and PRC2 regulatory hubs: A systematic and stratified approach to deliver new therapeutics for CML
    Leukaemia & Lymphoma Research
    2015 - 2020
     
  • Leukaemia and Lymphoma Research Therapy Acceleration Programme
    Leukaemia & Lymphoma Research
    2015 - 2016
     
  • Leukaemia and Lymphoma Research Therapy Acceleration Programme
    Leukaemia & Lymphoma Research
    2014 - 2014
     
  • Validating induced pluripotent stem cells (iPSC) as an acceptable model for pre-clinical drug screening in haematological malignancies
    Dr Hadwen Trust for Humane Research
    2014 - 2017
     
  • An investigation of the control of cell division and quiescence in leukaemic versus normal haemopoietic stem and progenitor cells
    Leukaemia & Lymphoma Research
    2014 - 2015
     
  • Investigation of JAK2 targets is myeloproliferative disorders
    Scottish Executive Health Department
    2013 - 2016
     
  • The importance of the Notch pathway and its interaction in the maintenance and progression of chronic myeloid leukaemia
    Wellcome Trust
    2013 - 2016
     
  • Wellcome Trust Scottish Translational Medicine and Therapeutics Initiative studentship
    Wellcome Trust
    2013 - 2016
     
  • Wellcome Trust Scottish Translational Medicine and Therapeutics Initiative studentship
    Wellcome Trust
    2012 - 2015
     
  • Leukaemia and Lymphoma Research Therapy Acceleration Programme
    Leukaemia & Lymphoma Research
    2012 - 2013
     
  • An investigation of the control of cell division and quiescence in leukaemic versus normal haemopoietic stem and progenitor cells
    Leukaemia & Lymphoma Research
    2011 - 2014
     
  • An investigation of the control of cell division and quiescence in leukaemic versus normal haemopoietic stem and progenitor cells
    Scottish Executive Health Department
    2009 - 2010
     
  • Self-renewal pathway manipulation as a potential therapeutic strategy for the eradication of Chronic Myeloid Leukaemia (CML) Stem Cells
    Scottish Executive Health Department
    2009 - 2011
     
  • Novel drug combinations for eradication of Ph+/Bcr-Abl+ haemopoietic stem cells in chronic myeloid leukaemia (CML)
    Leukaemia Research Trust for Scotland
    2003 - 2006
     
  • Novel drug combinations for eradication of Ph+/Bcr-Abl+ haemopoietic stem cells in chronic myeloid leukaemia (CML)
    MRC
    2003 - 2006
     

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2001
Number of items: 60.

2017

Brock, K., Billingham, L., Copland, M., Siddique, S., Sirovica, M. and Yap, C. (2017) Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology, 17, 112. (doi:10.1186/s12874-017-0381-x) (PMID:28728594) (PMCID:PMC5520236)

Clark, R. E. et al. (2017) De-escalation of tyrosine kinase inhibitor dose in patients with chronic myeloid leukaemia with stable major molecular response (DESTINY): an interim analysis of a non-randomised, phase 2 trial. Lancet Haematology, 4(7), e310-e316. (doi:10.1016/S2352-3026(17)30066-2) (PMID:28566209)

Horne, G. A. and Copland, M. (2017) Approaches for targeting self-renewal pathways in cancer stem cells: implications for hematological treatments. Expert Opinion on Drug Discovery, 12(5), pp. 465-474. (doi:10.1080/17460441.2017.1303477) (PMID:28277836)

2016

Kinstrie, R., Karamitros, D., Goardon, N., Morrison, H., Hamblin, M., Robinson, L., Clark, R. E., Copland, M. and Vyas, P. (2016) Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia. Blood Advances, 1(3), pp. 160-169. (doi:10.1182/bloodadvances.2016000810)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi:10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi:10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

Brehme, M., Koschmieder, S., Montazeri, M., Copland, M., Oehler, V. G., Radich, J. P., Brümmendorf, T. H., and Schuppert, A. (2016) Combined population dynamics and entropy modelling supports patient stratification in chronic myeloid leukemia. Scientific Reports, 6, 24057. (doi:10.1038/srep24057) (PMID:27048866) (PMCID:PMC4822142)

Schemionek, M. et al. (2016) MTSS1 is a critical epigenetically regulated tumor suppressor in CML. Leukemia, 30(4), pp. 823-830. (doi:10.1038/leu.2015.329) (PMID:26621336)

Lewis, M., Copland, M., Soverini, S., Sadovnik, I., Bedel, A., Prost, S., Italiano, A. and Mahon, F.-X. (2016) What are the challenges in 2016 regarding resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and cancer? Hematological Oncology, (doi:10.1002/hon.2329) (PMID:27435333) (Early Online Publication)

2015

Horne, G. A., Kinstrie, R. and Copland, M. (2015) Novel drug therapies in myelois leukemia: a patent review. Pharmaceutical Patent Analyst, 4(3), pp. 187-205. (doi:10.4155/ppa.15.3) (PMID:26030080)

Latif, A.-L., Cole, J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K., Copland, M. and Adams, P. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674.

2014

Lund, K., Cole, J., VanderKraats, N. D., McBryan, T., Pchelintsev, N. A., Clark, W., Copland, M., Edwards, J. R. and Adams, P. (2014) DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biology, 15(7), p. 406. (doi:10.1186/s13059-014-0406-2)

Burt, C., Parker, A., McQuaker, G., Copland, M., Brierley, C., Little, A. and Clark, A. (2014) In a 12-allele analysis HLA-DPB1 matching is associated with improved OS in leukaemic and myelodysplastic patients receiving myeloablative T-cell-depleted PBSCT from unrelated donors. Bone Marrow Transplantation, 49(5), pp. 657-663. (doi:10.1038/bmt.2014.8)

Lund, K., Cole, J., McBryan, T., Copland, M. and Adams, P. (2014) Investigating effects of epigenetic modulation in acute myeloid leukaemia. Lancet, 383(Supl 1), S70. (doi:10.1016/S0140-6736(14)60333-0) (PMID:19345831) (PMCID:PMC2866651)

Braig, M. et al. (2014) A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells. Leukemia, 28(10), pp. 2028-2039. (doi:10.1038/leu.2014.95) (PMID:24603533)

Lund, K., Adams, P.D. and Copland, M. (2014) EZH2 in normal and malignant hematopoiesis. Leukemia, 28(1), pp. 44-49. (doi:10.1038/leu.2013.288)

Pellicano, F. et al. (2014) The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells, 32(9), pp. 2324-2337. (doi:10.1002/stem.1748) (PMID:24806995) (PMCID:PMC4282530)

Toofan, P., Irvine, D., Hopcroft, L., Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi:10.1042/BST20140037)

2013

Gallipoli, P., Pellicano, F., Morrison, H., Laidlaw, K., Allan, E.K., Bhatia, R., Copland, M., Jorgensen, H.G. and Holyoake, T.L. (2013) Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation. Blood, 122(19), pp. 3335-3339. (doi:10.1182/blood-2013-02-485607)

Valent, P., Bonnet, D., Wohrer, S., Andreeff, M., Copland, M.,, Chomienne, C. and Eaves, C. (2013) Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications. Cancer Research, 73(3), pp. 1037-1045. (doi:10.1158/0008-5472.CAN-12-3678)

Balabanov, S., Evans, C.A., Abraham, S.A., Pellicano, F., Copland, M., Walker, M.J., Whetton, A.D. and Holyoake, T.L. (2013) Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients. Proteomics, 13(1), pp. 153-168. (doi:10.1002/pmic.201200022)

Cramer-Morales, K. et al. (2013) Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood, 122(7), pp. 1293-1304. (doi:10.1182/blood-2013-05-501072)

Rhodes, S., Copland, M., Hopcroft, L., Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi:10.1186/1478-811X-11-33)

2012

Kinstrie, R. and Copland, M. (2012) Targeting chronic myeloid leukemia stem cells. Current Hematologic Malignancy Reports, 8(1), pp. 14-21. (doi:10.1007/s11899-012-0148-8) (PMID:23264204)

Flis, K., Irvine, D., Copland, M., Bhatia, R. and Skorski, T. (2012) Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation. Leukemia and Lymphoma, 53(12), pp. 2474-2478. (doi:10.3109/10428194.2012.696313)

Eyre, T. et al. (2012) Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia. Blood, 120(22), pp. 4441-4443. (doi:10.1182/blood-2012-09-456517)

Eyre, T. et al. (2012) Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia. Blood, 120(22), pp. 4441-4443. (doi:10.1182/blood-2012-09-456517)

Valent, P. et al. (2012) Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews Cancer, 12(11), pp. 767-775. (doi:10.1038/nrc3368)

Rodgers, R., Latif, Z. and Copland, M. (2012) How I manage priapism in chronic myeloid leukaemia patients. British Journal of Haematology, 158(2), pp. 155-164. (doi:10.1111/j.1365-2141.2012.09151.x)

Faley, S., Copland, M., Reboud, J. and Cooper, J. M. (2012) Intracellular protein trafficking kinetics in chronic myeloid leukemia stem cells using a microfluidic platform. Integrative Biology, 4(4), p. 368. (doi:10.1039/c2ib00086e)

Irvine, D.A. and Copland, M. (2012) Targeting hedgehog in hematologic malignancy. Blood, 119(10), pp. 2196-2204. (doi:10.1182/blood-2011-10-383752)

2011

Pellicano, F., Simara, P., Sinclair, A., Helgason, G.V., Copland, M., Grant, S. and Holyoake, T.L. (2011) The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. Leukemia, 25(7), pp. 1159-67. (doi:10.1038/leu.2011.67)

Lucas, C. M., Harris, R. J., Giannoudis, A., Copland, M., Slupsky, J. R. and Clark, R. E. (2011) Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood, 117(24), pp. 6660-6668. (doi:10.1182/blood-2010-08-304477)

Faley, S.L., Copland, M., Reboud, J. and Cooper, J.M. (2011) Cell chip array for microfluidic proteomics enabling rapid in situ assessment of intracellular protein phosphorylation. Biomicrofluidics, 5(2), 024106. (doi:10.1063/1.3587095)

2009

Pellicano, F., Copland, M., Jorgensen, H. G., Mountford, J., Leber, B. and Holyoake, T. L. (2009) BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ. Blood, 114(19), pp. 4186-4196. (doi:10.1182/blood-2009-05-219550)

Faley, S. L., Copland, M., Wlodkowic, D., Kolch, W., Seale, K. T., Wikswo, J. P. and Cooper, J. M. (2009) Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Lab on a Chip, 9(18), pp. 2659-2664. (doi:10.1039/b902083g)

Copland, M. (2009) Ikaros deletions are associated with poor prognosis in acute lymphoblastic leukemia. Future Oncology, 5(4), pp. 455-458. (doi:10.2217/FON.09.16)

Copland, M. (2009) Chronic myelogenous leukemia stem cells: what's new? Current Hematologic Malignancy Reports, 4(2), pp. 66-73. (doi:10.1007/s11899-009-0010-9)

Copland, M., Michie, A. M. and Holyoake, T. L. (2009) Stem cells in Leukemia and other hematological malignancies. In: Majumder, S. (ed.) Stem Cells and Cancer. Springer New York: New York, NY, pp. 111-136. ISBN 9780387896106 (doi:10.1007/978-0-387-89611-3_5)

Faley, S.L., Copland, M., Wlodkovic, D., Kolch, W., Seale, K.T., Wikswo, J.P. and Cooper, J. (2009) Pachinko Biology: Gambling on Single Cells. In: 2009 35th Annual Northeast Bioengineering Conference. IEEE: New York, pp. 15-17. ISBN 978-1-4244-4362-8

2008

Konig, H., Copland, M., Chu, S., Jove, R., Holyoake, T. L. and Bhatia, R. (2008) Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells. Cancer Research, 68(23), pp. 9624-9633. (doi:10.1158/0008-5472.CAN-08-1131)

Heaney, N. B., Copland, M., Stewart, K., Godden, J., Parker, A. N., McQuaker, I. G., Smith, G. M., Crawley, C., Shepherd, P. and Holyoake, T. L. (2008) Complete molecular responses are achieved after reduced intensity stem cell transplantation and donor lymphocyte infusion in chronic myeloid leukemia. Blood, 111(10), pp. 5252-5255. (doi:10.1182/blood-2007-10-118141)

Copland, M., Pellicano, F., Richmond, L., Allan, E. K., Hamilton, A., Lee, F. Y., Weinmann, R. and Holyoake, T. L. (2008) BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood, 111(5), pp. 2843-2853. (doi:10.1182/blood-2007-09-112573)

2007

Holyoake, T. and Copland, M. (2007) LSC defenses breached by chemical arsenal. Blood, 110(13), pp. 4138-4139.

Balabanov, S. et al. (2007) Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood, 109(4), pp. 1701-1711. (doi:10.1182/blood-2005-03-037648)

Copland, M., Hamilton, A. and Holyoake, T. (2007) Conventional Western blotting techniques will not reliably quantify p210 BCR-ABL - Response. Blood, 109(3), p. 1336. (doi:/10.1182/blood-2006-10-050799)

Konig, H., Copland, M., Jove, R., Holyoake, T. and Bhatia, R. (2007) Effect of dasatinib on BCR-ABL and Src mediated growth signaling in primary CML hematopoietic progenitors. Blood, 110(11), 865A-865A.

2006

Copland, M., Hamilton, A., Eirick, L., Baird, J., Allan, E., Jordanides, N., Barow, M., Mountford, J. and Holyoake, T. (2006) Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood, 107(11), pp. 4532-4539. (doi:10.1182/blood-2005-07-2947)

Hamilton, A., Elrick, L., Myssina, S., Copland, M., Jorgensen, H.G., Melo, J.V. and Holyoake, T.L. (2006) BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry. Leukemia, 20(6), pp. 1035-1039. (doi:10.1038/sj.leu.2404189)

Jorgensen, H.G., Copland, M., Allan, E.K., Jiang, X.Y., Eaves, A., Eaves, C. and Holyoake, T.L. (2006) Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clinical Cancer Research, 12(2), pp. 626-633. (doi:10.1158/1078-0432.CCR-05-0429)

2005

Copland, M., Jorgensen, H.G. and Holyoake, T.L. (2005) Evolving molecular therapy for chronic myeloid leukaemia - are we on target? Hematology, 10(5), pp. 349-359. (doi:10.1080/10245330500234195)

Copland, M., Fraser, A., Harrison, S. and Holyoake, T. (2005) Targeting the silent minority: emerging immunotherapeutic strategies for eradication of malignant stem cells in chronic myeloid leukaemia. Cancer Immunology Immunotherapy, 54(4), pp. 297-306. (doi:10.1007/s00262-004-0573-1)

Allan, E., Jordanides, N., McLintock, L., Copland, M., Devaney, M., Stewart, K., Parker, A., Johnson, P., Holyoake, T. and Jones, B. (2005) Poor performance of galactomannan and mannan sandwich enzyme-linked immunosorbent assays in the diagnosis of invasive fungal infection. British Journal of Haematology, 128(4), pp. 578-579. (doi:10.1111/j.1365-2141.2004.05333.x)

Jordanides, N., Allan, E., McLintock, L., Copland, M., Devaney, M., Stewart, K., Parker, A., Johnson, P., Holyoake, T. and Jones, B. (2005) A prospective study of real-time panfungal PCR for the early diagnosis of invasive fungal infection in haemato-oncology patients. Bone Marrow Transplantation, 35(4), pp. 389-395. (doi:10.1038/sj.bmt.1704768)

Jorgensen, H.G., Copland, M. and Holyoake, T. (2005) Granulocyte-colony-stimulating factor (filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase myelogenous leukemia. Cancer, 103(1), pp. 210-211. (doi:10.1002/cncr.20742)

Copland, M., Hamilton, A., Baird, J., Barow, M., Allan, E., Elrick, L. and Holyoake, T. (2005) Dasatinib (BMS-354825) has increased activity against Bcr-Abl compared to imatinib in primary CML cells in vitro, but does not eradicate quiescent CML stem cells. Blood, 106(11), 205A-205A.

2004

McLintock, L., Jordanides, N., Allan, E., Copland, M., Stewart, K., Parker, A., Devaney, M., Holyoake, T. and Jones, B. (2004) The use of a risk group stratification in the management of invasive fungal infection: a prospective validation. British Journal of Haematology, 124(3), pp. 403-404. (doi:10.1046/j.1365-2141.2003.04794.x)

2003

Kilpatrick, D.C. et al. (2003) No strong relationship between mannan binding lectin or plasma ficolins and chemotherapy-related infections. Clinical and Experimental Immunology, 134(2), pp. 279-284. (doi:10.1046/j.1365-2249.2003.02284.x)

2001

Copland, M., Walker, I.D. and Tait, R.C. (2001) Oral anticoagulation and hemorrhagic complications in an elderly population with atrial fibrillation. Archives of Internal Medicine, 161(17), pp. 2125-2128. (doi:10.1001/archinte.161.17.2125)

This list was generated on Tue Aug 22 10:30:23 2017 BST.
Number of items: 60.

Articles

Brock, K., Billingham, L., Copland, M., Siddique, S., Sirovica, M. and Yap, C. (2017) Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology, 17, 112. (doi:10.1186/s12874-017-0381-x) (PMID:28728594) (PMCID:PMC5520236)

Clark, R. E. et al. (2017) De-escalation of tyrosine kinase inhibitor dose in patients with chronic myeloid leukaemia with stable major molecular response (DESTINY): an interim analysis of a non-randomised, phase 2 trial. Lancet Haematology, 4(7), e310-e316. (doi:10.1016/S2352-3026(17)30066-2) (PMID:28566209)

Horne, G. A. and Copland, M. (2017) Approaches for targeting self-renewal pathways in cancer stem cells: implications for hematological treatments. Expert Opinion on Drug Discovery, 12(5), pp. 465-474. (doi:10.1080/17460441.2017.1303477) (PMID:28277836)

Kinstrie, R., Karamitros, D., Goardon, N., Morrison, H., Hamblin, M., Robinson, L., Clark, R. E., Copland, M. and Vyas, P. (2016) Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia. Blood Advances, 1(3), pp. 160-169. (doi:10.1182/bloodadvances.2016000810)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi:10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi:10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

Brehme, M., Koschmieder, S., Montazeri, M., Copland, M., Oehler, V. G., Radich, J. P., Brümmendorf, T. H., and Schuppert, A. (2016) Combined population dynamics and entropy modelling supports patient stratification in chronic myeloid leukemia. Scientific Reports, 6, 24057. (doi:10.1038/srep24057) (PMID:27048866) (PMCID:PMC4822142)

Schemionek, M. et al. (2016) MTSS1 is a critical epigenetically regulated tumor suppressor in CML. Leukemia, 30(4), pp. 823-830. (doi:10.1038/leu.2015.329) (PMID:26621336)

Lewis, M., Copland, M., Soverini, S., Sadovnik, I., Bedel, A., Prost, S., Italiano, A. and Mahon, F.-X. (2016) What are the challenges in 2016 regarding resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and cancer? Hematological Oncology, (doi:10.1002/hon.2329) (PMID:27435333) (Early Online Publication)

Horne, G. A., Kinstrie, R. and Copland, M. (2015) Novel drug therapies in myelois leukemia: a patent review. Pharmaceutical Patent Analyst, 4(3), pp. 187-205. (doi:10.4155/ppa.15.3) (PMID:26030080)

Latif, A.-L., Cole, J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K., Copland, M. and Adams, P. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674.

Lund, K., Cole, J., VanderKraats, N. D., McBryan, T., Pchelintsev, N. A., Clark, W., Copland, M., Edwards, J. R. and Adams, P. (2014) DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biology, 15(7), p. 406. (doi:10.1186/s13059-014-0406-2)

Burt, C., Parker, A., McQuaker, G., Copland, M., Brierley, C., Little, A. and Clark, A. (2014) In a 12-allele analysis HLA-DPB1 matching is associated with improved OS in leukaemic and myelodysplastic patients receiving myeloablative T-cell-depleted PBSCT from unrelated donors. Bone Marrow Transplantation, 49(5), pp. 657-663. (doi:10.1038/bmt.2014.8)

Lund, K., Cole, J., McBryan, T., Copland, M. and Adams, P. (2014) Investigating effects of epigenetic modulation in acute myeloid leukaemia. Lancet, 383(Supl 1), S70. (doi:10.1016/S0140-6736(14)60333-0) (PMID:19345831) (PMCID:PMC2866651)

Braig, M. et al. (2014) A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells. Leukemia, 28(10), pp. 2028-2039. (doi:10.1038/leu.2014.95) (PMID:24603533)

Lund, K., Adams, P.D. and Copland, M. (2014) EZH2 in normal and malignant hematopoiesis. Leukemia, 28(1), pp. 44-49. (doi:10.1038/leu.2013.288)

Pellicano, F. et al. (2014) The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells, 32(9), pp. 2324-2337. (doi:10.1002/stem.1748) (PMID:24806995) (PMCID:PMC4282530)

Toofan, P., Irvine, D., Hopcroft, L., Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi:10.1042/BST20140037)

Gallipoli, P., Pellicano, F., Morrison, H., Laidlaw, K., Allan, E.K., Bhatia, R., Copland, M., Jorgensen, H.G. and Holyoake, T.L. (2013) Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation. Blood, 122(19), pp. 3335-3339. (doi:10.1182/blood-2013-02-485607)

Valent, P., Bonnet, D., Wohrer, S., Andreeff, M., Copland, M.,, Chomienne, C. and Eaves, C. (2013) Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications. Cancer Research, 73(3), pp. 1037-1045. (doi:10.1158/0008-5472.CAN-12-3678)

Balabanov, S., Evans, C.A., Abraham, S.A., Pellicano, F., Copland, M., Walker, M.J., Whetton, A.D. and Holyoake, T.L. (2013) Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients. Proteomics, 13(1), pp. 153-168. (doi:10.1002/pmic.201200022)

Cramer-Morales, K. et al. (2013) Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood, 122(7), pp. 1293-1304. (doi:10.1182/blood-2013-05-501072)

Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi:10.1186/1478-811X-11-33)

Kinstrie, R. and Copland, M. (2012) Targeting chronic myeloid leukemia stem cells. Current Hematologic Malignancy Reports, 8(1), pp. 14-21. (doi:10.1007/s11899-012-0148-8) (PMID:23264204)

Flis, K., Irvine, D., Copland, M., Bhatia, R. and Skorski, T. (2012) Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation. Leukemia and Lymphoma, 53(12), pp. 2474-2478. (doi:10.3109/10428194.2012.696313)

Eyre, T. et al. (2012) Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia. Blood, 120(22), pp. 4441-4443. (doi:10.1182/blood-2012-09-456517)

Eyre, T. et al. (2012) Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia. Blood, 120(22), pp. 4441-4443. (doi:10.1182/blood-2012-09-456517)

Valent, P. et al. (2012) Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews Cancer, 12(11), pp. 767-775. (doi:10.1038/nrc3368)

Rodgers, R., Latif, Z. and Copland, M. (2012) How I manage priapism in chronic myeloid leukaemia patients. British Journal of Haematology, 158(2), pp. 155-164. (doi:10.1111/j.1365-2141.2012.09151.x)

Faley, S., Copland, M., Reboud, J. and Cooper, J. M. (2012) Intracellular protein trafficking kinetics in chronic myeloid leukemia stem cells using a microfluidic platform. Integrative Biology, 4(4), p. 368. (doi:10.1039/c2ib00086e)

Irvine, D.A. and Copland, M. (2012) Targeting hedgehog in hematologic malignancy. Blood, 119(10), pp. 2196-2204. (doi:10.1182/blood-2011-10-383752)

Pellicano, F., Simara, P., Sinclair, A., Helgason, G.V., Copland, M., Grant, S. and Holyoake, T.L. (2011) The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. Leukemia, 25(7), pp. 1159-67. (doi:10.1038/leu.2011.67)

Lucas, C. M., Harris, R. J., Giannoudis, A., Copland, M., Slupsky, J. R. and Clark, R. E. (2011) Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood, 117(24), pp. 6660-6668. (doi:10.1182/blood-2010-08-304477)

Faley, S.L., Copland, M., Reboud, J. and Cooper, J.M. (2011) Cell chip array for microfluidic proteomics enabling rapid in situ assessment of intracellular protein phosphorylation. Biomicrofluidics, 5(2), 024106. (doi:10.1063/1.3587095)

Pellicano, F., Copland, M., Jorgensen, H. G., Mountford, J., Leber, B. and Holyoake, T. L. (2009) BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ. Blood, 114(19), pp. 4186-4196. (doi:10.1182/blood-2009-05-219550)

Faley, S. L., Copland, M., Wlodkowic, D., Kolch, W., Seale, K. T., Wikswo, J. P. and Cooper, J. M. (2009) Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Lab on a Chip, 9(18), pp. 2659-2664. (doi:10.1039/b902083g)

Copland, M. (2009) Ikaros deletions are associated with poor prognosis in acute lymphoblastic leukemia. Future Oncology, 5(4), pp. 455-458. (doi:10.2217/FON.09.16)

Copland, M. (2009) Chronic myelogenous leukemia stem cells: what's new? Current Hematologic Malignancy Reports, 4(2), pp. 66-73. (doi:10.1007/s11899-009-0010-9)

Konig, H., Copland, M., Chu, S., Jove, R., Holyoake, T. L. and Bhatia, R. (2008) Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells. Cancer Research, 68(23), pp. 9624-9633. (doi:10.1158/0008-5472.CAN-08-1131)

Heaney, N. B., Copland, M., Stewart, K., Godden, J., Parker, A. N., McQuaker, I. G., Smith, G. M., Crawley, C., Shepherd, P. and Holyoake, T. L. (2008) Complete molecular responses are achieved after reduced intensity stem cell transplantation and donor lymphocyte infusion in chronic myeloid leukemia. Blood, 111(10), pp. 5252-5255. (doi:10.1182/blood-2007-10-118141)

Copland, M., Pellicano, F., Richmond, L., Allan, E. K., Hamilton, A., Lee, F. Y., Weinmann, R. and Holyoake, T. L. (2008) BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood, 111(5), pp. 2843-2853. (doi:10.1182/blood-2007-09-112573)

Holyoake, T. and Copland, M. (2007) LSC defenses breached by chemical arsenal. Blood, 110(13), pp. 4138-4139.

Balabanov, S. et al. (2007) Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood, 109(4), pp. 1701-1711. (doi:10.1182/blood-2005-03-037648)

Copland, M., Hamilton, A. and Holyoake, T. (2007) Conventional Western blotting techniques will not reliably quantify p210 BCR-ABL - Response. Blood, 109(3), p. 1336. (doi:/10.1182/blood-2006-10-050799)

Konig, H., Copland, M., Jove, R., Holyoake, T. and Bhatia, R. (2007) Effect of dasatinib on BCR-ABL and Src mediated growth signaling in primary CML hematopoietic progenitors. Blood, 110(11), 865A-865A.

Copland, M., Hamilton, A., Eirick, L., Baird, J., Allan, E., Jordanides, N., Barow, M., Mountford, J. and Holyoake, T. (2006) Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood, 107(11), pp. 4532-4539. (doi:10.1182/blood-2005-07-2947)

Hamilton, A., Elrick, L., Myssina, S., Copland, M., Jorgensen, H.G., Melo, J.V. and Holyoake, T.L. (2006) BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry. Leukemia, 20(6), pp. 1035-1039. (doi:10.1038/sj.leu.2404189)

Jorgensen, H.G., Copland, M., Allan, E.K., Jiang, X.Y., Eaves, A., Eaves, C. and Holyoake, T.L. (2006) Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clinical Cancer Research, 12(2), pp. 626-633. (doi:10.1158/1078-0432.CCR-05-0429)

Copland, M., Jorgensen, H.G. and Holyoake, T.L. (2005) Evolving molecular therapy for chronic myeloid leukaemia - are we on target? Hematology, 10(5), pp. 349-359. (doi:10.1080/10245330500234195)

Copland, M., Fraser, A., Harrison, S. and Holyoake, T. (2005) Targeting the silent minority: emerging immunotherapeutic strategies for eradication of malignant stem cells in chronic myeloid leukaemia. Cancer Immunology Immunotherapy, 54(4), pp. 297-306. (doi:10.1007/s00262-004-0573-1)

Allan, E., Jordanides, N., McLintock, L., Copland, M., Devaney, M., Stewart, K., Parker, A., Johnson, P., Holyoake, T. and Jones, B. (2005) Poor performance of galactomannan and mannan sandwich enzyme-linked immunosorbent assays in the diagnosis of invasive fungal infection. British Journal of Haematology, 128(4), pp. 578-579. (doi:10.1111/j.1365-2141.2004.05333.x)

Jordanides, N., Allan, E., McLintock, L., Copland, M., Devaney, M., Stewart, K., Parker, A., Johnson, P., Holyoake, T. and Jones, B. (2005) A prospective study of real-time panfungal PCR for the early diagnosis of invasive fungal infection in haemato-oncology patients. Bone Marrow Transplantation, 35(4), pp. 389-395. (doi:10.1038/sj.bmt.1704768)

Jorgensen, H.G., Copland, M. and Holyoake, T. (2005) Granulocyte-colony-stimulating factor (filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase myelogenous leukemia. Cancer, 103(1), pp. 210-211. (doi:10.1002/cncr.20742)

Copland, M., Hamilton, A., Baird, J., Barow, M., Allan, E., Elrick, L. and Holyoake, T. (2005) Dasatinib (BMS-354825) has increased activity against Bcr-Abl compared to imatinib in primary CML cells in vitro, but does not eradicate quiescent CML stem cells. Blood, 106(11), 205A-205A.

McLintock, L., Jordanides, N., Allan, E., Copland, M., Stewart, K., Parker, A., Devaney, M., Holyoake, T. and Jones, B. (2004) The use of a risk group stratification in the management of invasive fungal infection: a prospective validation. British Journal of Haematology, 124(3), pp. 403-404. (doi:10.1046/j.1365-2141.2003.04794.x)

Kilpatrick, D.C. et al. (2003) No strong relationship between mannan binding lectin or plasma ficolins and chemotherapy-related infections. Clinical and Experimental Immunology, 134(2), pp. 279-284. (doi:10.1046/j.1365-2249.2003.02284.x)

Copland, M., Walker, I.D. and Tait, R.C. (2001) Oral anticoagulation and hemorrhagic complications in an elderly population with atrial fibrillation. Archives of Internal Medicine, 161(17), pp. 2125-2128. (doi:10.1001/archinte.161.17.2125)

Book Sections

Copland, M., Michie, A. M. and Holyoake, T. L. (2009) Stem cells in Leukemia and other hematological malignancies. In: Majumder, S. (ed.) Stem Cells and Cancer. Springer New York: New York, NY, pp. 111-136. ISBN 9780387896106 (doi:10.1007/978-0-387-89611-3_5)

Faley, S.L., Copland, M., Wlodkovic, D., Kolch, W., Seale, K.T., Wikswo, J.P. and Cooper, J. (2009) Pachinko Biology: Gambling on Single Cells. In: 2009 35th Annual Northeast Bioengineering Conference. IEEE: New York, pp. 15-17. ISBN 978-1-4244-4362-8

Conference Proceedings

Rhodes, S., Copland, M., Hopcroft, L., Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

This list was generated on Tue Aug 22 10:30:23 2017 BST.