Professor David Vetrie

Professor of Translational Leukaemia Genomics (Paul O'Gorman Leukaemia Research Centre)

telephone: 0141 330 7258
email: David.Vetrie@glasgow.ac.uk

Rm 311, Wolfson Wohl Cancer Research Centre, University of Glasgow, Garscube Estate, G61 1QH

https://orcid.org/0000-0003-2075-4662

Research interests

Gene Regulation in Normal Haematopoietic Development and Disease

My research addresses fundamental questions about the regulatory processes that control the expression of genes during normal haematopoietic development in both human and mouse. We use state-of-the-art approaches to study these processes both genome-wide and at specific gene loci. Similar approaches are also being implemented to understand the changes in transcriptional and regulatory programmes that occur during the development and treatment of leukaemia.

For more information see his Research pages as follows:

Research groups

Cancer Hallmarks to Novel Therapies
Cancer Evolution in Time & Space
Comprehensive Cancer Models
Leukaemia

Publications

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Number of items: 78.

2024

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15(1), 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)

Scott, M. T. et al. (2024) Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature Communications, 15, 651. (doi: 10.1038/s41467-024-44771-9) (PMID:38246924) (PMCID:PMC10800356)

2023

Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)

2022

Gómez-Castañeda, E., Hopcroft, L. E.M. , Rogers, S. , Munje, C., Bittencourt-Silvestre, J., Copland, M. , Vetrie, D. , Holyoake, T. and Jørgensen, H. G. (2022) Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy. Cancers, 14(21), 5253. (doi: 10.3390/cancers14215253) (PMID:36358672) (PMCID:PMC9655972)

Lebecque, B. et al. (2022) The spliceosome: a new therapeutic target in chronic myeloid leukaemia. Cancers, 14(19), 4695. (doi: 10.3390/cancers14194695) (PMID:36230624) (PMCID:PMC9563771)

2021

Ianniciello, A. et al. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13(613), eabd5016. (doi: 10.1126/scitranslmed.abd5016) (PMID:34586834)

Massett, M. E. et al. (2021) A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival. Cell Death and Disease, 12(6), 573. (doi: 10.1038/s41419-021-03738-0) (PMID:34083515) (PMCID:PMC8175737)

2020

Vetrie, D. , Helgason, V. and Copland, M. (2020) The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML. Nature Reviews Cancer, 20, pp. 158-173. (doi: 10.1038/s41568-019-0230-9) (PMID:31907378)

2019

Bugler, J., Kinstrie, R., Scott, M. T. and Vetrie, D. (2019) Epigenetic reprogramming and emerging epigenetic therapies in CML. Frontiers in Cell and Developmental Biology, 7, 136. (doi: 10.3389/fcell.2019.00136) (PMID:31380371) (PMCID:PMC6652210)

2018

Koschmieder, S. and Vetrie, D. (2018) Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options. Seminars in Cancer Biology, 51, pp. 180-197. (doi: 10.1016/j.semcancer.2017.07.006) (PMID:28778403)

2017

Holyoake, T. L. and Vetrie, D. (2017) The chronic myeloid leukemia stem cell: stemming the tide of persistence. Blood, 129(12), pp. 1595-1606. (doi: 10.1182/blood-2016-09-696013) (PMID:28159740)

Tarafdar, A. et al. (2017) CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression. Blood, 129(2), pp. 199-208. (doi: 10.1182/blood-2016-09-742049) (PMID:27793879) (PMCID:PMC5305055)

2016

Horne, G. A. , Morrison, H., Campbell, V., Kinstrie, R., Cassels, J., Hair, A., Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Scott, M. T. et al. (2016) Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition. Cancer Discovery, 6(11), pp. 1248-1257. (doi: 10.1158/2159-8290.CD-16-0263) (PMID:27630125) (PMCID:PMC6538532)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi: 10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

Gómez-Castañeda, E., Hopcroft, L.E.M. , Rogers, S. , Jorgensen, H.G. , Pellicano, F., Vetrie, D. , Copland, M. , Grimmond, S. and Holyoake, T.L. (2016) Uncovering the BCR-ABL1 Tyrosine Kinase Independent Signature in Chronic Myeloid Leukaemia Stem Cells. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. (doi: 10.1111/bjh.14019)

Jackson, L., Hopcroft, L.E.M. , Rogers, S. , Jorgensen, H., Pellicano, F., Wells, C., Mosbergen, R., Chen, T., Vetrie, D. and Holyoake, T.L. (2016) Identifying Genes and Pathways Deregulated in Chronic Myeloid Leukaemia Stem Cells Through Meta-Analysis of Transcriptomic Data. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. (doi: 10.1111/bjh.14019)

Michie, A.M. , Tarafdar, A., Gallipoli, P., Pellicano, F., Hopcroft, L. , Korfi, K., Cassels, J., Jorgensen, H.J. , Vetrie, D. and Holyoake, T.L. (2016) CML Cells Actively Evade Host Immune Surveillance Through Cytokine-Mediated Downregulation of MHC-I I Expression. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. p. 117. (doi: 10.1111/bjh.14019)

2015

Holyoake, T. and Vetrie, D. (2015) Cancer: repositioned to kill stem cells. Nature, 525(7569), pp. 328-329. (doi: 10.1038/nature15213) (PMID:26331538)

2013

Zhou, Y., Kurukuti, S., Saffrey, P., Vukovic, M., Michie, A.M. , Strogantsev, R., West, A.G. and Vetrie, D. (2013) Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Blood, 122(26), pp. 4199-4209. (doi: 10.1182/blood-2013-02-483875)

Scott, M. T. et al. (2013) Misregulation of the PRC2 Complex in CML Stem Cells Confers Sensitivity to an EZH2 Inhibitor. American Society of Hematology 55th Annual Meeting, New Orleans, LA, USA, 7-10 Dec 2013.

2012

Vetrie, D. et al. (2012) The gene involved in X-linked agammaglobulinaemia is a member of the Src family of protein-tyrosine kinases. 1993. Journal of Immunology, 188, pp. 2948-2955.

2010

Dhami, P. et al. (2010) Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS ONE, 5(2), e9059. (doi: 10.1371/journal.pone.0009059)

Dhami, P. et al. (2010) Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS ONE, 5(8), e12339. (doi: 10.1371/journal.pone.0012339)

2009

Bruce, A.W. et al. (2009) Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Research, 19(6), pp. 994-1006. (doi: 10.1101/gr.089086.108)

2008

Balikova, I. et al. (2008) Autosomal-dominant microtia linked to five tandem copies of a copy-number-variable region at chromosome 4p16. American Journal of Human Genetics, 82(1), pp. 181-187. (doi: 10.1016/j.ajhg.2007.08.001)

2007

Rodriguez, A. et al. (2007) Requirement of bic/microRNA-155 for normal immune function. Science, 316(5824), pp. 608-611. (doi: 10.1126/science.1139253) (PMID:17463290) (PMCID:PMC2610435)

Andrews, R. et al. (2007) The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Research, 17(6), pp. 691-707.

Birney, E. et al. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447(7146), pp. 799-816. (doi: 10.1038/nature05874) (PMCID:PMC2212820)

2006

Bolund, L. et al. (2006) Identification of novel deletion breakpoints bordered by segmental duplications in the NF1 locus using high resolution array-CGH. Journal of Medical Genetics, 43(1), pp. 28-38.

Bruce, A. et al. (2006) Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites. Genome Research, 16, pp. 1310-1319. (doi: 10.1101/gr.5373606)

2005

Abbs, S., Andrews, R., Coffey, A., Dhami, P., Dumanski, J., Langford, C., Vermeesch, J., Vetrie, D. and Woodward, K. (2005) Exon array CGH: Detection of copy-number changes at the resolution of individual exons in the human genome. American Journal of Human Genetics, 76, pp. 750-762.

Ameur, A. et al. (2005) Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays. Human Molecular Genetics, 14(22), pp. 3435-3447.

Bolund, L. et al. (2005) Identification of genetic aberrations on chromosome 22 outside the NF2 locus in schwannomatosis and neurofibromatosis type 2. Human Mutation, 26(6), pp. 540-549.

2004

Almeida, R. et al. (2004) Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome. Molecular and Biochemical Parasitology, 136, pp. 87-100. (doi: 10.1016/j.molbiopara.2004.03.004)

Boultwood, J. et al. (2004) Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. British Journal of Haematology, 125(5), pp. 576-583.

Breuning, M., Catsman-Berrevoets, C., Endris, V., Muncke, N., Rappold, G., Ross, M., Sistermans, E., Vetrie, D. and Wogatzky, B. (2004) Position effect on PLP1 may cause a subset of Pelizaeus-Merzbacher disease symptoms. Journal of Medical Genetics, 41(12),

Carter, N. and Vetrie, D. (2004) Applications of genomic microarrays to explore human chromosome structure and function. Human Molecular Genetics, 13, R297-R302.

Vetrie, D. (2004) The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306(5696), pp. 636-640. (doi: 10.1126/science.1105136) (PMID:15499007)

2003

Bahler, J., Burns, G., Chen, D.R., Langford, C., Lyne, R., Mata, J., Penkett, C.J., Rustici, G. and Vetrie, D. (2003) Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics, 4, 27. (doi: 10.1186/1471-2164-4-27)

Boultwood, J., Eagleton, H., Gama, S., Langford, C., Pellagatti, A., Vetrie, D. and Wainscoat, J. (2003) Gene expression profiling in polycythemia vera using cDNA microarray technology. Cancer Research, 63(14), pp. 3940-3944.

Burford, D., Carr, P., Carter, N., Douglas, E., Fiegler, H., Gorman, P., Hunt, S., Smith, J., Tomlinson, I. and Vetrie, D. (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes, Chromosomes and Cancer, 36(4), pp. 361-374.

Burford, D., Carr, P., Carter, N., Douglas, E., Fiegler, H., Gorman, P., Hunt, S., Smith, J., Tomlinson, I. and Vetrie, D. (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. (vol 36, pg 361, 2003). Genes, Chromosomes and Cancer, 37(2), p. 223.

Vetrie, D. , Vorechovsky, I. and Zhou, J. (2003) Molecular diagnosis of X-linked agammaglobulinaemia (vol 341, pg 1153, 1993). Lancet, 361(9366), p. 1394.

2002

Almeida, R. et al. (2002) From genomes to vaccines: Leishmania as a model. Philosophical Transactions of the Royal Society B: Biological Sciences, 357(1417), pp. 5-11. (doi: 10.1098/rstb.2001.0985) (PMID:11839176) (PMCID:PMC1692919)

2000

Plant, K. E., Boye, E., Green, P. M., Vetrie, D. and Flinter, F. A. (2000) Somatic mosaicism associated with a mild Alport syndrome phenotype. Journal of Medical Genetics, 37(3), pp. 238-239. (doi: 10.1136/jmg.37.3.238) (PMID:10777371) (PMCID:PMC1734534)

1999

Hassock, S., Vetrie, D. and Giannelli, F. (1999) Mapping and characterization of the X-linked dyskeratosis congenita (DKC) gene. Genomics, 55(1), pp. 21-27. (doi: 10.1006/geno.1998.5600) (PMID:9888995)

Jin, H., Kendall, E., Freeman, T. C., Roberts, R. G. and Vetrie, D. L.P. (1999) The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. Genomics, 61(3), pp. 259-267. (doi: 10.1006/geno.1999.5966) (PMID:10552927)

Plant, K. E., Green, P. M., Vetrie, D. and Flinter, F. A. (1999) Detection of mutations in COL4A5 in patients with Alport Syndrome. Human Mutation, 13(2), pp. 124-132. (doi: 10.1002/(SICI)1098-1004(1999)13:2<124::AID-HUMU4>3.0.CO;2-Z) (PMID:10094548)

1998

Woodward, K., Kendall, E., Vetrie, D. and Malcolm, S. (1998) Pelizaeus-Merzbacher disease: identification of Xq22 proteolipid-protein duplications and characterization of breakpoints by interphase FISH. American Journal of Human Genetics, 63(1), pp. 207-217. (doi: 10.1086/301933) (PMID:9634530) (PMCID:PMC1377253)

1997

Bastians, H., Krebber, H., Vetrie, D. , Hoheisel, J., Lichter, P., Ponstingl, H. and Joos, S. (1997) Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3. Genomics, 41(2), pp. 296-297. (doi: 10.1006/geno.1997.4640) (PMID:9143513)

Kendall, E., Evans, W., Jin, H., Holland, J. and Vetrie, D. (1997) A complete YAC contig and cosmid interval map covering the entirety of human Xq21.33 to Xq22.3 from DXS3 to DXS287. Genomics, 43(2), pp. 171-182. (doi: 10.1006/geno.1997.4795) (PMID:9244434)

1996

Jin, H. et al. (1996) A novel X–linked gene, DDP, shows mutations in families with deafness (DFN–1), dystonia, mental deficiency and blindness. Nature Genetics, 14(2), pp. 177-180. (doi: 10.1038/ng1096-177) (PMID:8841189)

Roberts, R. G., Freeman, T. C., Kendall, E., Vetrie, D. L.P. , Dixon, A. K., Shaw-Smith, C., Bone, Q. and Bobrow, M. (1996) Characterization of DRP2, a novel human dystrophin homologue. Nature Genetics, 13(2), pp. 223-226. (doi: 10.1038/ng0696-223) (PMID:8640231)

Roberts, R. G., Kendall, E., Vetrie, D. and Bobrow, M. (1996) Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene. Genomics, 37(1), pp. 122-124. (doi: 10.1006/geno.1996.0528) (PMID:8921378)

1995

Jin, H., Webster, A.D.B., Vihinen, M., Sideras, P., Vorechovsky, l., Hammarstróm, L., Bernatowska-Matuszkiewicz, E., Smith, C.I.E., Bobrow, M. and Vetrie, D. (1995) Identification of Btk mutations in 20 unrelated patients with X-Iinked agammaglobulinaemia (XLA). Human Molecular Genetics, 4(4), pp. 693-700. (doi: 10.1093/hmg/4.4.693) (PMID:7633420)

Vihinen, M. et al. (1995) BTKbase: a database of XLA-causing mutations. Immunology Today, 16(10), pp. 460-465. (doi: 10.1016/0167-5699(95)80027-1) (PMID:7576047)

1994

Vihinen, M., Vetrie, D. , Maniar, H. S., Ochs, H. D., Zhu, Q., Vorechovský, I., Webster, A. D. B., Notarangelo, L. D., Nilsson, L. and Sowadski, J. M. (1994) Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease. Proceedings of the National Academy of Sciences of the United States of America, 91(26), pp. 12803-12807. (PMID:7809124) (PMCID:PMC45528)

Flinter, F., Boye, E., Vetrie, D. , Harris, A. and Bobrow, M. (1994) Genetic aspects of renal dysfunction: Alport's syndrome. Clinical Investigator, 72(9), p. 728. (doi: 10.1007/BF00213005) (PMID:7849462)

Lovering, R. C. et al. (1994) Identification of deletions in the btk gene allows unambiguous assessment of carrier status in families with X-linked agammaglobulinaemia. Human Genetics, 94(1), pp. 77-79. (doi: 10.1007/BF02272846) (PMID:8034298)

Sideras, P. et al. (1994) Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci. Journal of Immunology, 153(12), pp. 5607-5617. (PMID:7989760)

Smith, C.I. et al. (1994) Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells. Journal of Immunology, 152(2), pp. 557-65. (PMID:8283037)

Vetrie, D. , Kendall, E., Coffey, A., Hassock, S., Collins, J., Todd, C., Lehrach, H., Bobrow, M., Bentley, D. R. and Harris, A. (1994) A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22. Genomics, 19(1), pp. 42-47. (doi: 10.1006/geno.1994.1010) (PMID:8188239)

Vořechovský, I. et al. (1994) Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22. Genomics, 21(3), pp. 517-524. (doi: 10.1006/geno.1994.1310) (PMID:7959728)

1993

Vetrie, D. , Bobrow, M. and Harris, A. (1993) Construction of a 5.2-megabase physical map of the human X chromosome at Xq22 using pulsed-field gel electrophoresis and yeast artificial chromosomes. Genomics, 15(3), pp. 631-642. (doi: 10.1006/geno.1993.1118) (PMID:8096829)

Flinter, F.A., Vetrie, D. and Bobrow, M. (1993) The implications of the cloning of the XLA gene. Journal of the Royal College of Physicians of London, 27(3), pp. 233-235. (PMID:8377154)

Vetrie, D. (1993) Isolation of the defective gene in X linked agammaglobulinaemia. Journal of Medical Genetics, 30(6), pp. 452-453. (PMID:8326486) (PMCID:PMC1016414)

Vetrie, D. , Bentley, D., Bobrow, M. and Harris, A. (1993) Physical mapping shows close linkage between the α-galactosidase A gene (GLA) and the DXS178 locus. Human Genetics, 92(1), pp. 95-99. (doi: 10.1007/BF00216154) (PMID:8103505)

Vetrie, D. et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature, 361(6409), pp. 226-233. (doi: 10.1038/361226a0) (PMID:8380905)

Vorechovský, I., Holland, J., Sideras, P., Dunham, I., Hammarström, L., Smith, C.I., Bentley, D.R. and Vetrie, D. (1993) Isolation of cDNA clones mapping around DXS178: a search for human X-linked agammaglobulinaemia gene using yeast artificial chromosomes, cosmids and direct cDNA selection. Immunodeficiency, 4(1-4), pp. 221-224.

Vorechovsky, I., Zhou, J.N., Vetrie, D. , Bentley, D., Björkander, J., Hammarström, L., Smith, C.I. and Vorechkovsky, I. (1993) Molecular diagnosis of X-linked agammaglobulinaemia. Lancet, 341(8853), p. 1153.

1992

Vetrie, D. , Boye, E., Flinter, F., Bobrow, M. and Harris, A. (1992) DNA rearrangements in the α5(IV) collagen gene (COL4A5) of individuals with alport syndrome: further refinement using pulsed-field gel electrophoresis. Genomics, 14(3), pp. 624-633. (doi: 10.1016/S0888-7543(05)80161-2) (PMID:1330889)

Vetrie, D. , Flinter, F., Bobrow, M. and Harris, A. (1992) Construction of a yeast artificial chromosome contig encompassing the human alpha 5(IV) collagen gene (COL4A5). Genomics, 14(3), pp. 634-642. (doi: 10.1016/S0888-7543(05)80162-4)

Harris, A., Collins, J., Vetrie, D. , Cole, C. and Bobrow, M. (1992) X inactivation as a mechanism of selection against lethal alleles: further investigation of incontinentia pigmenti and X linked lymphoproliferative disease. Journal of Medical Genetics, 29(9), pp. 608-614. (PMID:1404291) (PMCID:PMC1016090)

Vetrie, D. , Flinter, F., Bobrow, M. and Harris, A. (1992) Long-range mapping of the gene for the human α5(IV) collagen chain at Xq22–q23. Genomics, 12(1), pp. 130-138. (doi: 10.1016/0888-7543(92)90415-O) (PMID:1733850)

Vetrie, D. , Flinter, F., Bobrow, M. and Harris, A. (1992) X inactivation patterns in females with Alport's syndrome: a means of selecting against a deleterious gene? Journal of Medical Genetics, 29(9), pp. 663-666. (PMID:1404298) (PMCID:PMC1016101)

1991

Boye, E., Vetrie, D. , Flinter, F., Buckle, B., Pihlajaniemi, T., Hamalainen, E.-R., Myers, J. C., Bobrow, M. and Harris, A. (1991) Major rearrangements in the α5(IV) collagen gene in three patients with alport syndrome. Genomics, 11(4), pp. 1125-1132. (doi: 10.1016/0888-7543(91)90040-L) (PMID:1783380)

1990

Neil, D. L., Villasante, A., Fisher, R. B., Vetrie, D. , Cox, B. and Tyler-Smit, C. (1990) Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors. Nucleic Acids Research, 18(6), pp. 1421-1428. (doi: 10.1093/nar/18.6.1421) (PMID:2183192) (PMCID:PMC330506)

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