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Prof Anthony Chalmers

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Chair of Clinical Oncology (Clinical Trials Research)

email: Anthony.Chalmers@glasgow.ac.uk

Glioblastoma is the commonest and most aggressive primary brain tumour and is often refractory to conventional cancer treatments. The ultimate aim of our research group is to improve outcomes for patients with these tumours by overcoming their inherent resistance to radiotherapy and chemotherapy.

Much of our work has focused on the DNA repair protein poly(ADP-ribose) polymerase, commonly known as PARP. Drugs that inhibit PARP increase the sensitivity of tumour cells to radiotherapy and to chemotherapy agents such as temozolomide. We are currently developing a series of clinical trials to test whether PARP inhibitors can be safely and effectively combined with radiotherapy and chemotherapy in patients with glioblastoma.

Current and future work will also investigate the effect of the tumour microenvironment on radiation responses of glioblastoma cells. In order to do this we are developing a novel in vitro cell culture system that recapitulates some of the key features of the glioblastoma microenvironment.

Biography

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Number of items: 14.

2013

Hellevik, T., Pettersen, I., Berg, V., Bruun, J., Bartnes, K., Busund, T.-L., Chalmers, A., Bremnes,, R., and Martinez-Zubiaurre, I. (2013) Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: potential impact on angiogenesis and tumor growth. Translational Onocology, 6 (1). pp. 66-74. ISSN 1936-5233

2012

Alagoz, M., Gilbert, D.C., El-Khamisy, S., and Chalmers, A. (2012) DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets. Current Medicinal Chemistry, 19 (23). pp. 3874-3885. ISSN 0929-8673 (doi:10.2174/092986712802002590)

Ford, E., Catt, S., Chalmers, A., and Fallowfield, L. (2012) Systematic review of supportive care needs in patients with primary malignant brain tumors. Neuro-Oncology, 14 (4). pp. 392-404. ISSN 1522-8517 (doi:10.1093/neuonc/nor229)

Gilbert, D.C., Chalmers, A.J., and El-Khamisy, S.F. (2012) Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets. British Journal of Cancer, 106 (1). pp. 18-24. ISSN 0007-0920 (doi:10.1038/bjc.2011.498)

Hellevik, T. et al. (2012) Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiation Oncology, 7 (59). ISSN 1748-717X (doi:10.1186/1748-717X-7-59)

2011

Catt, S.L., Anderson, J.L., Chalmers, A.J., and Fallowfield, L.J. (2011) A UK-wide survey of follow-up practices for patients with high-grade glioma treated with radical intent. Journal of Evaluation in Clinical Practice, 17 (1). pp. 1-6. ISSN 1356-1294 (doi:10.1111/j.1365-2753.2009.01292.x)

Mannino, M., and Chalmers, A.J. (2011) Radioresistance of glioma stem cells: Intrinsic characteristic or property of the 'microenvironment-stem cell unit'? Molecular Oncology, 5 (4). pp. 374-386. ISSN 1574-7891 (doi:10.1016/j.molonc.2011.05.001)

2010

Chalmers, A.J., Lakshman, M., Chan, N., and Bristow, R.G. (2010) Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets. Seminars in Radiation Oncology, 20 (4). pp. 274-281. ISSN 1053-4296 (doi:10.1016/j.semradonc.2010.06.001)

Chalmers, A.J. (2010) Overcoming resistance of glioblastoma to conventional cytotoxic therapies by the addition of PARP inhibitors. Anti-Cancer Agents in Medicinal Chemistry, 10 (7). pp. 520-533. ISSN 1871-5206 (doi:10.2174/187152010793498627)

Chalmers, A.J. (2010) Evaluating novel radiation techniques for the treatment of cerebral metastases. British Journal of Radiology, 83 (986). pp. 98-100. ISSN 0007-1285 (doi:10.1259/bjr/15790337)

Löser, D.A., Shibata, A., Shibata, A.K., Woodbine, L.J., Jeggo, P.A., and Chalmers, A.J. (2010) Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Molecular Cancer Therapeutics, 9 (6). pp. 1775-1787. ISSN 1535-7163 (doi:10.1158/1535-7163.MCT-09-1027)

2009

Chalmers, A.J., Ruff, E.M., Martindale, C., Lovegrove, N., and Short, S.C. (2009) Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent. International Journal of Radiation Oncology, Biology, Physics, 75 (5). pp. 1511-1519. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2009.07.1703)

Dungey, F.A., Caldecott, K.W., and Chalmers, A.J. (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2245. ISSN 1535-7163 (doi:10.1158/1535-7163.MCT-09-0201)

2008

Dungey, F.A., Löser, D.A., and Chalmers, A.J. (2008) Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-ribose) polymerase: mechanisms and therapeutic potential. International Journal of Radiation Oncology, Biology, Physics, 72 (4). pp. 1188-1197. ISSN 0360-3016 (doi:10.1016/j.ijrobp.2008.07.031)

This list was generated on Tue Jun 18 12:46:47 2013 BST.

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