Professor Sara Zanivan
- Professor (Beatson Institute for Cancer Research)
email:
Sara.Zanivan@glasgow.ac.uk
Beatson Institute for Cancer, Garscube, Switchback
https://orcid.org/0000-0002-9880-9099Publications
2024
Santi, A. et al. (2024) Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science Signaling, (Accepted for Publication)
Vringer, E. et al. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43(6), pp. 904-930. (doi: 10.1038/s44318-024-00044-1) (PMID:38337057) (PMCID:PMC10943237)
Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)
Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (Early Online Publication)
2023
Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)
Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)
Kay, E. J. and Zanivan, S. (2023) Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular Oncology, 17(4), pp. 541-544. (doi: 10.1002/1878-0261.13400) (PMID:36807529)
Subramaniam, G. et al. (2023) Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy. Circulation Research, 132(7), pp. 828-848. (doi: 10.1161/CIRCRESAHA.122.321448) (PMID:36883446)
Schmidt, T. et al. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51(4), pp. 1859-1879. (doi: 10.1093/nar/gkad030) (PMID:36727461) (PMCID:PMC9976904)
Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)
2022
Kugeratski, F. G., Santi, A. and Zanivan, S. (2022) Extracellular vesicles as central regulators of blood vessel function in cancer. Science Signaling, 15(753), eaaz4742. (doi: 10.1126/scisignal.aaz4742) (PMID:36166511)
Gioelli, N. et al. (2022) Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability. Nature Communications, 13, 4188. (doi: 10.1038/s41467-022-31904-1) (PMID:35858913) (PMCID:PMC9300702)
Baudot, A. D. et al. (2022) Glycan degradation promotes macroautophagy. Proceedings of the National Academy of Sciences of the United States of America, 119(26), e211150611. (doi: 10.1073/pnas.2111506119) (PMID:35737835)
Närvä, E. et al. (2022) MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience, 25(6), 104459. (doi: 10.1016/j.isci.2022.104459) (PMID:35677646) (PMCID:PMC9167974)
Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)
Salji, M. J. et al. (2022) Multi-omics and pathway analysis identify potential roles for tumour n-acetyl aspartate accumulation in murine models of castration resistant prostate cancer. iScience, 25(4), 104056. (doi: 10.1016/j.isci.2022.104056) (PMID:35345457) (PMCID:PMC8957019)
Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14(3), e14764. (doi: 10.15252/emmm.202114764) (PMID:35014179) (PMCID:PMC8899912)
2021
Marco, S. et al. (2021) Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nature Communications, 12, 6829. (doi: 10.1038/s41467-021-26839-y) (PMID:34819513) (PMCID:PMC8613289)
Gillen, S. L., Giacomelli, C., Hodge, K., Zanivan, S. , Bushell, M. and Wilczynska, A. (2021) Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization. Genome Biology, 22, 284. (doi: 10.1186/s13059-021-02494-w) (PMID:34615539) (PMCID:PMC8496106)
Martinez, R. S. et al. (2021) SLFN5 regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer. Cancer Research, 81(13), pp. 3664-3678. (doi: 10.1158/0008-5472.CAN-20-3694) (PMID:33985973)
Paterson, K., Zanivan, S. , Glasspool, R., Coffelt, S.B. and Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21(12), pp. 2306-2329. (doi: 10.1039/D0LC01305F) (PMID:34085677) (PMCID:PMC8204114)
Budden, T. et al. (2021) Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nature Communications, 12, 2742. (doi: 10.1038/s41467-021-22953-z) (PMID:33980846) (PMCID:PMC8115293)
Ahmed, S. F., Buetow, L., Gabrielsen, M. , Lilla, S., Sibbet, G. J., Sumpton, D., Zanivan, S. , Hedley, A., Clark, W. and Huang, D. T. (2021) E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis. Oncogene, 40(12), pp. 2149-2164. (doi: 10.1038/s41388-021-01684-x) (PMID:33627783) (PMCID:PMC7994203)
Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)
Domen, A. et al. (2021) Cancer-associated fibroblasts as a common orchestrator of therapy resistance in lung and pancreatic cancer. Cancers, 13(5), 987. (doi: 10.3390/cancers13050987) (PMID:33673405) (PMCID:PMC7956441)
Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1-382. (doi: 10.1080/15548627.2020.1797280) (PMID:33634751) (PMCID:PMC7996087)
2020
Lobo, M. J. et al. (2020) Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. Communications Biology, 3, 596. (doi: 10.1038/s42003-020-01311-7) (PMID:33087821) (PMCID:PMC7578833)
Ahmed, S. F., Buetow, L., Gabrielsen, M. , Lilla, S., Chatrin, C., Sibbet, G. J., Zanivan, S. and Huang, D. T. (2020) DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Science Advances, 6(34), eabc0629. (doi: 10.1126/sciadv.abc0629) (PMID:32937373) (PMCID:PMC7442474)
Taskinen, M. E. et al. (2020) MASTL promotes cell contractility and motility through kinase-independent signaling. Journal of Cell Biology, 219(6), e20190620. (doi: 10.1083/jcb.201906204) (PMID:32311005) (PMCID:PMC7265322)
Blomme, A. et al. (2020) 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nature Communications, 11, 2508. (doi: 10.1038/s41467-020-16126-7) (PMID:32427840) (PMCID:PMC7237503)
Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)
Cao, X., Lilla, S., Cao, Z., Pringle, M. A., Oka, O. B.V. , Robinson, P. J. , Szmaja, T., Van Lith, M., Zanivan, S. and Bulleid, N. (2020) The mammalian cytosolic thioredoxin reductase pathway acts via a membrane 1 protein to reduce ER-localised proteins. Journal of Cell Science, 133, jcs241976. (doi: 10.1242/jcs.241976) (PMID:32184267) (PMCID:PMC7197872)
Loveridge, C. J. et al. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x) (PMID:31740786) (PMCID:PMC7033044)
Unbekandt, M., Lilla, S., Zanivan, S. R. and Olson, M. F. (2020) The CDC42 effector protein MRCKß autophosphorylates on Threonine 1108. Small GTPases, 11(6), pp. 451-460. (doi: 10.1080/21541248.2018.1564472) (PMID:30667325) (PMCID:PMC7549636)
2019
Wilczynska, A. et al. (2019) eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5’UTR. Genome Biology, 20, 262. (doi: 10.1186/s13059-019-1857-2) (PMID:31791371) (PMCID:PMC6886185)
Whitelaw, J. A., Lilla, S., Paul, N. R., Fort, L., Zanivan, S. and Machesky, L. M. (2019) CYRI/ Fam49 proteins represent a new class of Rac1 interactors. Communicative and Integrative Biology, 12(1), pp. 112-118. (doi: 10.1080/19420889.2019.1643665) (PMID:31413787) (PMCID:PMC6682259)
Ferraro, D., Patella, F., Zanivan, S. R., Donato, C., Aceto, N., Giannotta, M., Dejana, E., Diepenbruck, M., Christofori, G. and Buess, M. (2019) Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells. BMC Cancer, 19, 312. (doi: 10.1186/s12885-019-5521-8) (PMID:30947697) (PMCID:PMC6449935)
Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)
2018
Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)
Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)
Dandoulaki, M., Petsalaki, E., Sumpton, D., Zanivan, S. and Zachos, G. (2018) Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis. Journal of Cell Biology, 217(9), pp. 3071-3089. (doi: 10.1083/jcb.201802102) (PMID:29954829) (PMCID:PMC6122982)
Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)
van der Reest, J., Lilla, S., Zheng, L., Zanivan, S. and Gottlieb, E. (2018) Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress. Nature Communications, 9, 1581. (doi: 10.1038/s41467-018-04003-3) (PMID:29679077) (PMCID:PMC5910380)
Santi, A., Kugeratski, F. G. and Zanivan, S. (2018) Cancer associated fibroblasts: the architects of stroma remodelling. Proteomics, 18(5-6), 1700167. (doi: 10.1002/pmic.201700167) (PMID:29280568) (PMCID:PMC5900985)
Kugeratski, F. G., Batista, M., Lima, C. V. d. P., Neilson, L. J., da Cunha, E. S., de Godoy, L. M., Zanivan, S., Krieger, M. A. and Marchini, F. K. (2018) Mitogen-activated protein kinase kinase 5 regulates proliferation and biosynthetic processes in procyclic forms of Trypanosoma brucei. Journal of Proteome Research, 17(1), pp. 108-118. (doi: 10.1021/acs.jproteome.7b00415) (PMID:29043805)
2017
van den Eshof, B. L., Hoogendijk, A. J., Simpson, P. J., van Alphen, F. P.J., Zanivan, S. , Mertens, K., Meijer, A. B. and van den Biggelaar, M. (2017) Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), pp. 1891-1902. (doi: 10.1161/ATVBAHA.117.309926) (PMID:28818855)
Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)
Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)
Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I. , Edwards, J. , Zanivan, S. and Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130(4), pp. 697-711. (doi: 10.1242/jcs.190835) (PMID:28062852)
Norman, J. and Zanivan, S. (2017) Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), pp. 1993-1994. (doi: 10.1080/15384101.2017.1377031) (PMID:28933594)
Reid, S. E. and Zanivan, S. (2017) Tumor stiffness extends its grip on the metastatic microenvironment. Molecular and Cellular Oncology, 4(6), e1372866. (doi: 10.1080/23723556.2017.1372866)
2016
Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K. , Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166) (PMID:27246970)
Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)
2015
Deschoemaeker, S. et al. (2015) PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Molecular Medicine, 7(10), pp. 1350-65. (doi: 10.15252/emmm.201505492) (PMID:26290450) (PMCID:PMC4604688)
Kuchnio, A. et al. (2015) The cancer cell oxygen sensor PHD2 promotes metastasis via activation of cancer-associated fibroblasts. Cell Reports, 12(6), pp. 992-1005. (doi: 10.1016/j.celrep.2015.07.010) (PMID:26235614)
Patella, F. et al. (2015) Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular and Cellular Proteomics, 14(3), pp. 621-634. (doi: 10.1074/mcp.M114.045575) (PMID:25573745) (PMCID:PMC4349982)
2014
Guo, Z., Neilson, L. J., Zhong, H., Murray, P. S., Zanivan, S. R. and Zaidel-Bar, R. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Science Signaling, 7(354), rs7. (doi: 10.1126/scisignal.2005473)
van den Biggelaar, M., Hernández-Fernaud, J. R., van den Eshof, B. L., Neilson, L. J., Meijer, A. B., Mertens, K. and Zanivan, S. (2014) Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells. Blood, 123(12), e22-e36. (doi: 10.1182/blood-2013-12-546036)
Reid, S., Hernandez-Fernaud, J. R. and Zanivan, S. (2014) In vivo quantitative proteomics for the study of oncometabolism. Methods in Enzymology, 543, pp. 235-259. (doi: 10.1016/B978-0-12-801329-8.00012-X)
2013
Zanivan, S. , Maione, F., Hein, M. Y., Hernandez-Fernaud, J. R., Ostasiewicz, P., Giraudo, E. and Mann, M. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Molecular and Cellular Proteomics, 12(12), pp. 3599-3611. (doi: 10.1074/mcp.M113.031344)
Hernandez, J.R., Reid, S.E., Neilson, L.J. and Zanivan, S. (2013) Quantitative mass spectrometry-based proteomics in angiogenesis. Proteomics Clinical Applications, 7(7-8), pp. 464-476. (doi: 10.1002/prca.201200055)
Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi: 10.1038/onc.2012.148)
Zanivan, S. et al. (2013) In Vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports, 3(2), pp. 552-566. (doi: 10.1016/j.celrep.2013.01.003)
Neuhauser, N., Nagaraj, N., McHardy, P., Zanivan, S. , Scheltema, R., Cox, J. and Mann, M. (2013) High performance computational analysis of large-scale proteome data sets to assess incremental contribution to coverage of the human genome. Journal of Proteome Research, 12(6), pp. 2858-2868. (doi: 10.1021/pr400181q)
Schiller, H.B. et al. (2013) β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nature Cell Biology, 15(6), pp. 625-636. (doi: 10.1038/ncb2747)
2011
Scholten, A., Mohammed, S., Low, T. Y., Zanivan, S. , van Veen, T. A.B., Delanghe, B. and Heck, A. J.R. (2011) In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse. Molecular and Cellular Proteomics, 10(10), O111.00847. (doi: 10.1074/mcp.O111.008474) (PMID:21705516) (PMCID:PMC3205878)
Meves, A., Geiger, T., Zanivan, S. , DiGiovanni, J., Mann, M. and Fassler, R. (2011) β1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation. Proceedings of the National Academy of Sciences of the United States of America, 108(37), pp. 15213-15218. (doi: 10.1073/pnas.1105689108)
2008
Zanivan, S. , Gnad, F., Wickstrom, S. A., Geiger, T., Macek, B., Cox, J., Fassler, R. and Mann, M. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. Journal of Proteome Research, 7(12), pp. 5314-5326. (doi: 10.1021/pr800599n) (PMID:19367708)
Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C.A., Forner, F., Schmidt, S., Zanivan, S. , Fässler, R. and Mann, M. (2008) Silac mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell, 134(2), pp. 353-364. (doi: 10.1016/j.cell.2008.05.033)
2007
Zanivan, S. , Cascone, I., Peyron, C., Molineris, I., Marchio, S., Caselle, M. and Bussolino, F. (2007) A new computational approach to analyze human protein complexes and predict novel protein interactions. Genome Biology, 8, R256. (doi: 10.1186/gb-2007-8-12-r256) (PMID:18053208) (PMCID:PMC2246258)
2005
Parsons-Wingerter, P. et al. (2005) Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors. American Journal of Pathology, 167(1), pp. 193-211. (doi: 10.1016/s0002-9440(10)62965-3) (PMID:15972964) (PMCID:PMC1603436)
2003
Serini, G. et al. (2003) Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature, 424, pp. 391-397. (doi: 10.1038/nature01784) (PMID:12879061)
Articles
Santi, A. et al. (2024) Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science Signaling, (Accepted for Publication)
Vringer, E. et al. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43(6), pp. 904-930. (doi: 10.1038/s44318-024-00044-1) (PMID:38337057) (PMCID:PMC10943237)
Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)
Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (Early Online Publication)
Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)
Kay, E. J. and Zanivan, S. (2023) Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular Oncology, 17(4), pp. 541-544. (doi: 10.1002/1878-0261.13400) (PMID:36807529)
Subramaniam, G. et al. (2023) Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy. Circulation Research, 132(7), pp. 828-848. (doi: 10.1161/CIRCRESAHA.122.321448) (PMID:36883446)
Schmidt, T. et al. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51(4), pp. 1859-1879. (doi: 10.1093/nar/gkad030) (PMID:36727461) (PMCID:PMC9976904)
Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)
Kugeratski, F. G., Santi, A. and Zanivan, S. (2022) Extracellular vesicles as central regulators of blood vessel function in cancer. Science Signaling, 15(753), eaaz4742. (doi: 10.1126/scisignal.aaz4742) (PMID:36166511)
Gioelli, N. et al. (2022) Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability. Nature Communications, 13, 4188. (doi: 10.1038/s41467-022-31904-1) (PMID:35858913) (PMCID:PMC9300702)
Baudot, A. D. et al. (2022) Glycan degradation promotes macroautophagy. Proceedings of the National Academy of Sciences of the United States of America, 119(26), e211150611. (doi: 10.1073/pnas.2111506119) (PMID:35737835)
Närvä, E. et al. (2022) MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience, 25(6), 104459. (doi: 10.1016/j.isci.2022.104459) (PMID:35677646) (PMCID:PMC9167974)
Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)
Salji, M. J. et al. (2022) Multi-omics and pathway analysis identify potential roles for tumour n-acetyl aspartate accumulation in murine models of castration resistant prostate cancer. iScience, 25(4), 104056. (doi: 10.1016/j.isci.2022.104056) (PMID:35345457) (PMCID:PMC8957019)
Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14(3), e14764. (doi: 10.15252/emmm.202114764) (PMID:35014179) (PMCID:PMC8899912)
Marco, S. et al. (2021) Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nature Communications, 12, 6829. (doi: 10.1038/s41467-021-26839-y) (PMID:34819513) (PMCID:PMC8613289)
Gillen, S. L., Giacomelli, C., Hodge, K., Zanivan, S. , Bushell, M. and Wilczynska, A. (2021) Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization. Genome Biology, 22, 284. (doi: 10.1186/s13059-021-02494-w) (PMID:34615539) (PMCID:PMC8496106)
Martinez, R. S. et al. (2021) SLFN5 regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer. Cancer Research, 81(13), pp. 3664-3678. (doi: 10.1158/0008-5472.CAN-20-3694) (PMID:33985973)
Paterson, K., Zanivan, S. , Glasspool, R., Coffelt, S.B. and Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21(12), pp. 2306-2329. (doi: 10.1039/D0LC01305F) (PMID:34085677) (PMCID:PMC8204114)
Budden, T. et al. (2021) Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nature Communications, 12, 2742. (doi: 10.1038/s41467-021-22953-z) (PMID:33980846) (PMCID:PMC8115293)
Ahmed, S. F., Buetow, L., Gabrielsen, M. , Lilla, S., Sibbet, G. J., Sumpton, D., Zanivan, S. , Hedley, A., Clark, W. and Huang, D. T. (2021) E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis. Oncogene, 40(12), pp. 2149-2164. (doi: 10.1038/s41388-021-01684-x) (PMID:33627783) (PMCID:PMC7994203)
Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)
Domen, A. et al. (2021) Cancer-associated fibroblasts as a common orchestrator of therapy resistance in lung and pancreatic cancer. Cancers, 13(5), 987. (doi: 10.3390/cancers13050987) (PMID:33673405) (PMCID:PMC7956441)
Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1-382. (doi: 10.1080/15548627.2020.1797280) (PMID:33634751) (PMCID:PMC7996087)
Lobo, M. J. et al. (2020) Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. Communications Biology, 3, 596. (doi: 10.1038/s42003-020-01311-7) (PMID:33087821) (PMCID:PMC7578833)
Ahmed, S. F., Buetow, L., Gabrielsen, M. , Lilla, S., Chatrin, C., Sibbet, G. J., Zanivan, S. and Huang, D. T. (2020) DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Science Advances, 6(34), eabc0629. (doi: 10.1126/sciadv.abc0629) (PMID:32937373) (PMCID:PMC7442474)
Taskinen, M. E. et al. (2020) MASTL promotes cell contractility and motility through kinase-independent signaling. Journal of Cell Biology, 219(6), e20190620. (doi: 10.1083/jcb.201906204) (PMID:32311005) (PMCID:PMC7265322)
Blomme, A. et al. (2020) 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nature Communications, 11, 2508. (doi: 10.1038/s41467-020-16126-7) (PMID:32427840) (PMCID:PMC7237503)
Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)
Cao, X., Lilla, S., Cao, Z., Pringle, M. A., Oka, O. B.V. , Robinson, P. J. , Szmaja, T., Van Lith, M., Zanivan, S. and Bulleid, N. (2020) The mammalian cytosolic thioredoxin reductase pathway acts via a membrane 1 protein to reduce ER-localised proteins. Journal of Cell Science, 133, jcs241976. (doi: 10.1242/jcs.241976) (PMID:32184267) (PMCID:PMC7197872)
Loveridge, C. J. et al. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x) (PMID:31740786) (PMCID:PMC7033044)
Unbekandt, M., Lilla, S., Zanivan, S. R. and Olson, M. F. (2020) The CDC42 effector protein MRCKß autophosphorylates on Threonine 1108. Small GTPases, 11(6), pp. 451-460. (doi: 10.1080/21541248.2018.1564472) (PMID:30667325) (PMCID:PMC7549636)
Wilczynska, A. et al. (2019) eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5’UTR. Genome Biology, 20, 262. (doi: 10.1186/s13059-019-1857-2) (PMID:31791371) (PMCID:PMC6886185)
Whitelaw, J. A., Lilla, S., Paul, N. R., Fort, L., Zanivan, S. and Machesky, L. M. (2019) CYRI/ Fam49 proteins represent a new class of Rac1 interactors. Communicative and Integrative Biology, 12(1), pp. 112-118. (doi: 10.1080/19420889.2019.1643665) (PMID:31413787) (PMCID:PMC6682259)
Ferraro, D., Patella, F., Zanivan, S. R., Donato, C., Aceto, N., Giannotta, M., Dejana, E., Diepenbruck, M., Christofori, G. and Buess, M. (2019) Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells. BMC Cancer, 19, 312. (doi: 10.1186/s12885-019-5521-8) (PMID:30947697) (PMCID:PMC6449935)
Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)
Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)
Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)
Dandoulaki, M., Petsalaki, E., Sumpton, D., Zanivan, S. and Zachos, G. (2018) Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis. Journal of Cell Biology, 217(9), pp. 3071-3089. (doi: 10.1083/jcb.201802102) (PMID:29954829) (PMCID:PMC6122982)
Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)
van der Reest, J., Lilla, S., Zheng, L., Zanivan, S. and Gottlieb, E. (2018) Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress. Nature Communications, 9, 1581. (doi: 10.1038/s41467-018-04003-3) (PMID:29679077) (PMCID:PMC5910380)
Santi, A., Kugeratski, F. G. and Zanivan, S. (2018) Cancer associated fibroblasts: the architects of stroma remodelling. Proteomics, 18(5-6), 1700167. (doi: 10.1002/pmic.201700167) (PMID:29280568) (PMCID:PMC5900985)
Kugeratski, F. G., Batista, M., Lima, C. V. d. P., Neilson, L. J., da Cunha, E. S., de Godoy, L. M., Zanivan, S., Krieger, M. A. and Marchini, F. K. (2018) Mitogen-activated protein kinase kinase 5 regulates proliferation and biosynthetic processes in procyclic forms of Trypanosoma brucei. Journal of Proteome Research, 17(1), pp. 108-118. (doi: 10.1021/acs.jproteome.7b00415) (PMID:29043805)
van den Eshof, B. L., Hoogendijk, A. J., Simpson, P. J., van Alphen, F. P.J., Zanivan, S. , Mertens, K., Meijer, A. B. and van den Biggelaar, M. (2017) Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), pp. 1891-1902. (doi: 10.1161/ATVBAHA.117.309926) (PMID:28818855)
Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)
Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)
Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I. , Edwards, J. , Zanivan, S. and Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130(4), pp. 697-711. (doi: 10.1242/jcs.190835) (PMID:28062852)
Norman, J. and Zanivan, S. (2017) Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), pp. 1993-1994. (doi: 10.1080/15384101.2017.1377031) (PMID:28933594)
Reid, S. E. and Zanivan, S. (2017) Tumor stiffness extends its grip on the metastatic microenvironment. Molecular and Cellular Oncology, 4(6), e1372866. (doi: 10.1080/23723556.2017.1372866)
Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K. , Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166) (PMID:27246970)
Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)
Deschoemaeker, S. et al. (2015) PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Molecular Medicine, 7(10), pp. 1350-65. (doi: 10.15252/emmm.201505492) (PMID:26290450) (PMCID:PMC4604688)
Kuchnio, A. et al. (2015) The cancer cell oxygen sensor PHD2 promotes metastasis via activation of cancer-associated fibroblasts. Cell Reports, 12(6), pp. 992-1005. (doi: 10.1016/j.celrep.2015.07.010) (PMID:26235614)
Patella, F. et al. (2015) Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular and Cellular Proteomics, 14(3), pp. 621-634. (doi: 10.1074/mcp.M114.045575) (PMID:25573745) (PMCID:PMC4349982)
Guo, Z., Neilson, L. J., Zhong, H., Murray, P. S., Zanivan, S. R. and Zaidel-Bar, R. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Science Signaling, 7(354), rs7. (doi: 10.1126/scisignal.2005473)
van den Biggelaar, M., Hernández-Fernaud, J. R., van den Eshof, B. L., Neilson, L. J., Meijer, A. B., Mertens, K. and Zanivan, S. (2014) Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells. Blood, 123(12), e22-e36. (doi: 10.1182/blood-2013-12-546036)
Reid, S., Hernandez-Fernaud, J. R. and Zanivan, S. (2014) In vivo quantitative proteomics for the study of oncometabolism. Methods in Enzymology, 543, pp. 235-259. (doi: 10.1016/B978-0-12-801329-8.00012-X)
Zanivan, S. , Maione, F., Hein, M. Y., Hernandez-Fernaud, J. R., Ostasiewicz, P., Giraudo, E. and Mann, M. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Molecular and Cellular Proteomics, 12(12), pp. 3599-3611. (doi: 10.1074/mcp.M113.031344)
Hernandez, J.R., Reid, S.E., Neilson, L.J. and Zanivan, S. (2013) Quantitative mass spectrometry-based proteomics in angiogenesis. Proteomics Clinical Applications, 7(7-8), pp. 464-476. (doi: 10.1002/prca.201200055)
Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi: 10.1038/onc.2012.148)
Zanivan, S. et al. (2013) In Vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports, 3(2), pp. 552-566. (doi: 10.1016/j.celrep.2013.01.003)
Neuhauser, N., Nagaraj, N., McHardy, P., Zanivan, S. , Scheltema, R., Cox, J. and Mann, M. (2013) High performance computational analysis of large-scale proteome data sets to assess incremental contribution to coverage of the human genome. Journal of Proteome Research, 12(6), pp. 2858-2868. (doi: 10.1021/pr400181q)
Schiller, H.B. et al. (2013) β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nature Cell Biology, 15(6), pp. 625-636. (doi: 10.1038/ncb2747)
Scholten, A., Mohammed, S., Low, T. Y., Zanivan, S. , van Veen, T. A.B., Delanghe, B. and Heck, A. J.R. (2011) In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse. Molecular and Cellular Proteomics, 10(10), O111.00847. (doi: 10.1074/mcp.O111.008474) (PMID:21705516) (PMCID:PMC3205878)
Meves, A., Geiger, T., Zanivan, S. , DiGiovanni, J., Mann, M. and Fassler, R. (2011) β1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation. Proceedings of the National Academy of Sciences of the United States of America, 108(37), pp. 15213-15218. (doi: 10.1073/pnas.1105689108)
Zanivan, S. , Gnad, F., Wickstrom, S. A., Geiger, T., Macek, B., Cox, J., Fassler, R. and Mann, M. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. Journal of Proteome Research, 7(12), pp. 5314-5326. (doi: 10.1021/pr800599n) (PMID:19367708)
Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C.A., Forner, F., Schmidt, S., Zanivan, S. , Fässler, R. and Mann, M. (2008) Silac mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell, 134(2), pp. 353-364. (doi: 10.1016/j.cell.2008.05.033)
Zanivan, S. , Cascone, I., Peyron, C., Molineris, I., Marchio, S., Caselle, M. and Bussolino, F. (2007) A new computational approach to analyze human protein complexes and predict novel protein interactions. Genome Biology, 8, R256. (doi: 10.1186/gb-2007-8-12-r256) (PMID:18053208) (PMCID:PMC2246258)
Parsons-Wingerter, P. et al. (2005) Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors. American Journal of Pathology, 167(1), pp. 193-211. (doi: 10.1016/s0002-9440(10)62965-3) (PMID:15972964) (PMCID:PMC1603436)
Serini, G. et al. (2003) Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature, 424, pp. 391-397. (doi: 10.1038/nature01784) (PMID:12879061)
Conference or Workshop Item
Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)
Supervision
- Drabwell, Owen
Automated cell sorting platforms using Al-assisted Raman spectroscopy
Research datasets
2018
Monteverde, T., Neilson, L., Zanivan, S. R. and Murphy, D. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. [Data Collection]
2015
Patella, F., Schug, Z. T., Persi, E., Neilson, L., Erami, Z., Avanzato, D., Maione, F., Hernandez-Fernaud, J. R., Mackay, G., Zheng, L., Reid, S., Frezza, C., Giraudo, E., Pla, A. F., Anderson, K., Ruppin, E., Gottlieb, E. and Zanivan, S. R. (2015) Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability. [Data Collection]