2013

Hudson, B.D., Ulven, T., and Milligan, G. (2013) The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs. Current Topics in Medicinal Chemistry, 13 (1). pp. 14-25. ISSN 1568-0266 (doi:10.2174/1568026611313010004)

2012

Hudson, B., Tikhonova, I., Pandey, S., Ulven, T., and Milligan, G. (2012) Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. Journal of Biological Chemistry, 287 (49). pp. 41195-41209. ISSN 0021-9258 (doi:10.1074/jbc.M112.396259)

Christiansen, E. et al. (2012) Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties. Journal of Medicinal Chemistry, 55 (14). pp. 6624-6628. ISSN 0022-2623 (doi:10.1021/jm3002026)

Shimpukade, B., Hudson, B.D., Hogaard, C.K., Milligan, G., and Ulven, T. (2012) Discovery of a potent and selective GPR120 agonist. Journal of Medicinal Chemistry, 55 (9). pp. 4511-4515. ISSN 0022-2623 (doi:10.1021/jm300215x)

Terhzaz, S., Cabrero, P., Robben, J.H., Radford, J.C., Hudson, B., Milligan, G., Dow, J.A.T., and Davies, S. (2012) Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7 (1). e29897. ISSN 1932-6203 (doi:10.1371/journal.pone.0029897)

Terhzaz, S., Cabrero, P., Robben, J.H., Radford, J.C., Hudson, B.D., Milligan, G., Dow, J.A.T., and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7 (1). e29897. ISSN 1932-6203 (doi:10.1371/journal.pone.0029897)

2011

Smith, N.J. et al. (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Molecular Pharmacology, 80 (1). pp. 163-173. ISSN 0026-895X (doi:10.1124/mol.110.070789)

Schmidt, J. et al. (2011) Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. Journal of Biological Chemistry, 286 (12). pp. 10628-10640. ISSN 0021-9258 (doi:10.1074/jbc.M110.210872)

Hudson, B.D., Smith, N.J., and Milligan, G. (2011) Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors. In: Neubig, R.R. (ed.) Pharmacology of G Protein Coupled Receptors. Series: Advances in Pharmacology (62). Elsevier Academic Press, Amsterdam, The Netherlands, pp. 175-218. ISBN 9780123859525

2010

Jenkins, L., Brea, J., Smith, N.J., Hudson, B.D., Reilly, G., Bryant, N.J., Castro, M., Loza, M.I., and Milligan, G. (2010) Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13. Biochemical Journal, 432 (3). pp. 451-459. ISSN 0264-6021 (doi:10.1042/BJ20101287)