Dr Richard Reeve

  • Research Fellow (Institute of Biodiversity Animal Health and Comparative Medicine)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413306638
email: Richard.Reeve@glasgow.ac.uk

Biography

I am a co-director of the Boyd Orr Centre for Population and Ecosystem Health at the University of Glasgow, where I have been based since coming back into academia in 2007. I am a core-funded research fellow in the Institute of Biodiversity, Animal Health and Comparative Medicine the university, and I hold a visiting fellowship on the Livestock Viral Diseases Programme at BBSRC’s Pirbright Institute. I am also affiliated to the MRC / University of Glasgow Centre for Virus Research, and a member of the Glasgow Centre for International Development.

Research interests

 

Google Scholar - Publications Profile

I am a modeller with a background in artificial intelligence. I moved into the life sciences in 2007 to study diversity. My work focusses on developing the connections between different fields that use diversity measures, from the level of the transcript to the ecosystem, and the underlying mathematics.

On the application side, much of my work is on how to measure similarity of individuals, and how to integrate this into diversity measures. I have a particular focus on antigenic similarity of viruses, especially foot-and-mouth disease and flu, where I work on the relationship between their genotypic and phenotypic evolution. This has applications in vaccine selection, which is a diversity-related problem, in this case one of maximising the diversity of viruses covered by a specific vaccine.

On the mathematical side, my interests are in the spatial and temporal partitioning of diversity, and how we can identify viral phenotypes or areas in an ecosystem that are distinct from the rest, that contribute particularly to overall diversity of the system, or that are changing faster than their surroundings.

I also work with colleagues interested in the emergence of antimicrobial resistance phenotypes and genotypes, and how we can identify sources of novel phenotypes from their background diversity or similarity to existing strains, and also on the diversity of the major histocompatibility complex in sheep and cattle, and its relationship to disease resistance.

Much of my work involves the application of mathematical, computational and statistical tools to underexploited biological datasets, particularly focussing on pathogens and vaccines, where large amounts of data are collected on protection for testing purposes which can be reused to investigate vaccine:immune system interaction. I am more generally interested in epidemiological systems and host-pathogen interactions, particularly how they affect our ability to predict the effects of vaccines in the real world. I am currently involved several projects funded by the UK government and research councils as well as the EU and the FAO.

I have also worked with the FMD Vaccine Group at Pirbright to understand how we can better assess vaccine efficacy (funded by DEFRA), and this collaboration includes SENASA in Argentina, and I have been part of a broader European project with all of the main European FMD research laboratories to improve FMDV vaccine efficacy testing and cross-protection prediction (with EU FP-7 funding).

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • An effective vaccination programme for the eradication of foot-and-mouth disease from India
    Biotechnology and Biological Sciences Research Council
    2014 - 2017
     
  • The influence of selective breeding on MHC diversity
    Biotechnology and Biological Sciences Research Council
    2014 - 2017
     
  • Assessing the impact of foot-and-mouth disease vaccination programmes
    Biotechnology and Biological Sciences Research Council
    2013 - 2017
     
  • SULSA LEADERS Application
    Scottish Universities Life Sciences Alliance
    2013 - 2015
     
  • The Mathematics of Biodiversity.
    Biotechnology and Biological Sciences Research Council
    2012 - 2012
     
  • Pirbirght Institute External Research Fellowship
    Biotechnology and Biological Sciences Research Council
    2012 - 2017
     
  • Improving the quality of FMD (Foot-and-mouth disease) vaccines by understanding the correlation of vaccine-induced protection with humoral and cellular inmmune responses
    BBSRC
    2011 - 2014
     
  • Towards potency by serological assessment - modelling new and archived FMD challenge data from vaccinated cattle
    Institute for Animal Health
    2010 - 2011
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009
Number of items: 17.

2015

Bari, F. D., Parida, S., Asfor, A. S., Haydon, D. T., Reeve, R., Paton, D. J., and Mahapatra, M. (2015) Prediction and characterization of novel epitopes of serotype A foot-and-mouth disease viruses circulating in East Africa using site-directed mutagenesis. Journal of General Virology, 96, pp. 1033-1041. (doi:10.1099/vir.0.000051) (PMID:25614587)

2014

Ikeda, Y., Gilbert, M., Miquelle, D. G., Goodrich, J. M., Reeve, R., Cleaveland, S., Matthews, L., and Joly, D. O. (2014) Estimating the potential impact of canine distemper virus on the Amur tiger population (Panthera tigris altaica) in Russia. PLoS ONE, 9(10), e110811. (doi:10.1371/journal.pone.0110811)

Bari, F. D., Parida, S., Tekleghiorghis, T., Dekker, A., Sangula, A., Reeve, R., Haydon, D. T., Paton, D. J., and Mahapatra, M. (2014) Genetic and antigenic characterisation of serotype A FMD viruses from East Africa to select new vaccine strains. Vaccine, 32(44), pp. 5794-5800. (doi:10.1016/j.vaccine.2014.08.033)

Davies, V., Reeve, R., Harvey, W., Maree, F., and Husmeier, D. (2014) Sparse Bayesian Variable Selection for the Identiļ¬cation of Antigenic Variability in the Foot-and-Mouth Disease Virus. Journal of Machine Learning Research: Workshop and Conference Proceedings, 33, pp. 149-158.

2013

Casey, M.B. et al. (2013) Patterns of foot-and-mouth disease virus distribution in Africa. In: Johnson, N. (ed.) The Role of Animals in Emerging Viral Diseases. Academic Press, pp. 21-38. ISBN 9780124051911 (doi:10.1016/B978-0-12-405191-1.00002-8)

Matthews, L. et al. (2013) Predicting the public health benefit of vaccinating cattle against Escherichia coli O157. Proceedings of the National Academy of Sciences of the United States of America, 110(40), pp. 16265-16270. (doi:10.1073/pnas.1304978110)

Lyimo, I.N., Haydon, D., Russell, T.L., Mbina, K.F., Daraja, A.A., Mbehela, E.M., Reeve, R., and Ferguson, H. (2013) The impact of host species and vector control measures on the fitness of African malaria vectors. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1754), p. 20122823. (doi:10.1098/rspb.2012.2823)

2012

Lyimo, I.N., Haydon, D., Mbina, K.F., Daraja, A.A., Mbehela, E.M., Reeve, R., and Ferguson, H. (2012) The fitness of African malaria vectors in the presence and limitation of host behaviour. Malaria Journal, 11, p. 425. (doi:10.1186/1475-2875-11-425)

Masden, E.A., Reeve, R., Desholm, M., Fox, A.D., Furness, R.W., and Haydon, D.T. (2012) Assessing the impact of marine wind farms on birds through movement modelling. Journal of The Royal Society Interface, 9(74), pp. 2120-2130. (doi:10.1098/rsif.2012.0121)

Mather, A.E. et al. (2012) The diversity of antimicrobial resistance is different in Salmonella Typhimurium DT104 from co-located animals and humans. Proceedings of the Royal Society of London Series B: Biological Sciences, 279(1740), pp. 2924-2925. (doi:10.1098/rspb.2012.0614)

Codner, G.F., Stear, M.J., Reeve, R., Matthews, L., and Ellis, S.A. (2012) Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle. Animal Genetics, 43(3), pp. 239-249. (doi:10.1111/j.1365-2052.2011.02239.x)

Mather, A.E. et al. (2012) An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations. Proceedings of the Royal Society of London Series B: Biological Sciences, 279(1733), pp. 1630-1639. (doi:10.1098/rspb.2011.1975)

2011

Reeve, R., Cox, S., Smitsaart, E., Beascoechea, C.P., Haas, B., Maradei, E., Haydon, D.T., and Barnett, P. (2011) Reducing animal experimentation in foot-and-mouth disease vaccine potency tests. Vaccine, 29(3), pp. 5467-5473. (doi:10.1016/j.vaccine.2011.05.056)

2010

Stift, M., Reeve, R., and van Tienderen, P.H. (2010) Inheritance in tetraploid yeast revisited: segregation patterns and statistical power under different inheritance models. Journal of Evolutionary Biology, 23(7), pp. 1570-1578. (doi:10.1111/j.1420-9101.2010.02012.x)

Lindstrom, J., Reeve, R., and Salvidio, S. (2010) Bayesian salamanders: analysing the demography of an underground population of the European plethodontid Speleomantes strinatii with state-space modelling. BMC Ecology, 10, p. 4. (doi:10.1186/1472-6785-10-4)

Reeve, R. et al. (2010) Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus. PLoS Computational Biology, 6(12), e1001027. (doi:10.1371/journal.pcbi.1001027)

2009

Matthews, L., Reeve, R., Woolhouse, M.E.J., Mellor, D., Pearce, M.C., Allison, L.J., Gunn, G.J., Low, J.C., and Reid, S.W.J. (2009) Exploiting strain diversity to expose transmission heterogeneities and predict the impact of targeting supershedding. Epidemics, 1(4), pp. 221-229. (doi:10.1016/j.epidem.2009.10.002)

This list was generated on Thu Jul 30 14:30:09 2015 BST.
Number of items: 17.

Articles

Bari, F. D., Parida, S., Asfor, A. S., Haydon, D. T., Reeve, R., Paton, D. J., and Mahapatra, M. (2015) Prediction and characterization of novel epitopes of serotype A foot-and-mouth disease viruses circulating in East Africa using site-directed mutagenesis. Journal of General Virology, 96, pp. 1033-1041. (doi:10.1099/vir.0.000051) (PMID:25614587)

Ikeda, Y., Gilbert, M., Miquelle, D. G., Goodrich, J. M., Reeve, R., Cleaveland, S., Matthews, L., and Joly, D. O. (2014) Estimating the potential impact of canine distemper virus on the Amur tiger population (Panthera tigris altaica) in Russia. PLoS ONE, 9(10), e110811. (doi:10.1371/journal.pone.0110811)

Bari, F. D., Parida, S., Tekleghiorghis, T., Dekker, A., Sangula, A., Reeve, R., Haydon, D. T., Paton, D. J., and Mahapatra, M. (2014) Genetic and antigenic characterisation of serotype A FMD viruses from East Africa to select new vaccine strains. Vaccine, 32(44), pp. 5794-5800. (doi:10.1016/j.vaccine.2014.08.033)

Davies, V., Reeve, R., Harvey, W., Maree, F., and Husmeier, D. (2014) Sparse Bayesian Variable Selection for the Identiļ¬cation of Antigenic Variability in the Foot-and-Mouth Disease Virus. Journal of Machine Learning Research: Workshop and Conference Proceedings, 33, pp. 149-158.

Matthews, L. et al. (2013) Predicting the public health benefit of vaccinating cattle against Escherichia coli O157. Proceedings of the National Academy of Sciences of the United States of America, 110(40), pp. 16265-16270. (doi:10.1073/pnas.1304978110)

Lyimo, I.N., Haydon, D., Russell, T.L., Mbina, K.F., Daraja, A.A., Mbehela, E.M., Reeve, R., and Ferguson, H. (2013) The impact of host species and vector control measures on the fitness of African malaria vectors. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1754), p. 20122823. (doi:10.1098/rspb.2012.2823)

Lyimo, I.N., Haydon, D., Mbina, K.F., Daraja, A.A., Mbehela, E.M., Reeve, R., and Ferguson, H. (2012) The fitness of African malaria vectors in the presence and limitation of host behaviour. Malaria Journal, 11, p. 425. (doi:10.1186/1475-2875-11-425)

Masden, E.A., Reeve, R., Desholm, M., Fox, A.D., Furness, R.W., and Haydon, D.T. (2012) Assessing the impact of marine wind farms on birds through movement modelling. Journal of The Royal Society Interface, 9(74), pp. 2120-2130. (doi:10.1098/rsif.2012.0121)

Mather, A.E. et al. (2012) The diversity of antimicrobial resistance is different in Salmonella Typhimurium DT104 from co-located animals and humans. Proceedings of the Royal Society of London Series B: Biological Sciences, 279(1740), pp. 2924-2925. (doi:10.1098/rspb.2012.0614)

Codner, G.F., Stear, M.J., Reeve, R., Matthews, L., and Ellis, S.A. (2012) Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle. Animal Genetics, 43(3), pp. 239-249. (doi:10.1111/j.1365-2052.2011.02239.x)

Mather, A.E. et al. (2012) An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations. Proceedings of the Royal Society of London Series B: Biological Sciences, 279(1733), pp. 1630-1639. (doi:10.1098/rspb.2011.1975)

Reeve, R., Cox, S., Smitsaart, E., Beascoechea, C.P., Haas, B., Maradei, E., Haydon, D.T., and Barnett, P. (2011) Reducing animal experimentation in foot-and-mouth disease vaccine potency tests. Vaccine, 29(3), pp. 5467-5473. (doi:10.1016/j.vaccine.2011.05.056)

Stift, M., Reeve, R., and van Tienderen, P.H. (2010) Inheritance in tetraploid yeast revisited: segregation patterns and statistical power under different inheritance models. Journal of Evolutionary Biology, 23(7), pp. 1570-1578. (doi:10.1111/j.1420-9101.2010.02012.x)

Lindstrom, J., Reeve, R., and Salvidio, S. (2010) Bayesian salamanders: analysing the demography of an underground population of the European plethodontid Speleomantes strinatii with state-space modelling. BMC Ecology, 10, p. 4. (doi:10.1186/1472-6785-10-4)

Reeve, R. et al. (2010) Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus. PLoS Computational Biology, 6(12), e1001027. (doi:10.1371/journal.pcbi.1001027)

Matthews, L., Reeve, R., Woolhouse, M.E.J., Mellor, D., Pearce, M.C., Allison, L.J., Gunn, G.J., Low, J.C., and Reid, S.W.J. (2009) Exploiting strain diversity to expose transmission heterogeneities and predict the impact of targeting supershedding. Epidemics, 1(4), pp. 221-229. (doi:10.1016/j.epidem.2009.10.002)

Book Sections

Casey, M.B. et al. (2013) Patterns of foot-and-mouth disease virus distribution in Africa. In: Johnson, N. (ed.) The Role of Animals in Emerging Viral Diseases. Academic Press, pp. 21-38. ISBN 9780124051911 (doi:10.1016/B978-0-12-405191-1.00002-8)

This list was generated on Thu Jul 30 14:30:09 2015 BST.