Professor Eileen Devaney

  • Professor of Parasite Immunobiology (Institute of Biodiversity Animal Health and Comparative Medicine)
  • Associate Academic (School of Veterinary Medicine)
  • Associate Academic (Institute of Infection Immunity and Inflammation)

telephone: 01413306925
email: Eileen.Devaney@glasgow.ac.uk

Research interests

Google Scholar - Publications Profile

Research Interests:

My interests are around nematode biology, in particular filarial nematodes and immunomodulation; understanding anthelmintic resistance in veterinary nematodes; the role of microRNAs in the regulation of nematode gene expression; and Hsp90 as a molecular target in parasites.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • United States-UK partnering award:Co-infection and resistance (CORE)
    Biotechnology and Biological Sciences Research Council
    2016 - 2020
     
  • Monepantel: anthelmintic resistance and the development of tools for sustainable use
    The Scottish Government
    2016 - 2017
     
  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2015 - 2016
     
  • The BUG consortium Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasites
    Biotechnology and Biological Sciences Research Council
    2015 - 2020
     
  • Hsp90 as a modulator of pathogenicity, virulence and transmission in Theileria and Babesia
    Biotechnology and Biological Sciences Research Council
    2014 - 2017
     
  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2014 - 2015
     
  • Illuminating the darkness: exploiting IVIS imaging technology
    Gates Foundation
    2014 - 2015
     
  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2013 - 2014
     
  • microRNAs and drug resistance in parasitic nematodes
    Wellcome Trust
    2011 - 2012
     
  • microRNAs and drug resistance in parasitic nematodes
    Wellcome Trust
    2011 - 2015
     
  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2011 - 2013
     
  • Hsp90 as a molecular target in filarial worms
    Scottish Funding Council
    2009 - 2011
     
  • Comparative genomics of nematodes: defining the role of miRNAs in development
    Wellcome Trust
    2009 - 2012
     
  • A comparative analysis of Hsp90 its possible role in drug resistance in nematode parasites
    BBSRC
    2007 - 2011
     
  • Hsp90 as a molecular target in lymphatic filariasis
    Wellcome Trust
    2005 - 2008
     
  • Molecular genetics and biochemistry of parasites
    MRC
    2004 - 2009
     

Additional information

Editorial Board

  • 2004 - ongoing: Journal of Helminthology
  • 2001 - 2007: Filarial Journal
  • 1997 - 2010: Annals of Tropical Medicine and Hygiene
  • 1994 - ongoing: Parasite Immunology - Management Committee from 2003 onwards

Grant Advisory Board

  • 2009 - 2010: BBSRC - Pool A Member
  • 2005 - 2005: EU - Independent Expert for Inco-Dev-3, Framework 6
  • 2004 - 2009: MRC - College of Experts

Invited International Presentations

  • 2010: Melbourne, Australia - ICOPA
  • 2007: Canberra, Australia - Australian Society of Parasitology
  • 2006: Berlin, Germany - Consortium of Infection Biology
  • 2005: Hamburg, Germany - Helminths as modulators of Immunity

Professional Learned Society

  • - ongoing: British Society for Immunology - Ordinary Member
  • - ongoing: British Society for Parasitology - Ordinary Member. Steering Committee ICOPA 2006.

Research Fellowship

  • 1993 - 1998: Wellcome Trust University Award
  • 1987 - 1993: MRC Senior Non-clinical Fellowship
  • 1983 - 1987: Wellcome Trust Training Award in Tropical Medicine

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998
Number of items: 51.

2016

Kinnaird, J. H., Singh, M., Gillan, V., Weir, W., Calder, E. D.D., Hostettler, I., Tatu, U., and Devaney, E. (2016) Characterisation of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata. Cellular Microbiology, (doi:10.1111/cmi.12669) (PMID:27649068) (Early Online Publication)

Bilsland, E., Bean, D. M., Devaney, E., and Oliver, S. G. (2016) Yeast-based high-throughput screens to identify novel compounds active against Brugia malayi. PLoS Neglected Tropical Diseases, 10(1), e0004401. (doi:10.1371/journal.pntd.0004401) (PMID:26812604) (PMCID:PMC4727890)

Devaney, E., and Gillan, V. (2016) Hsp90 inhibitors in parasitic nematodes: prospects and challenges. Current Topics in Medicinal Chemistry, 16(25), pp. 2805-2811. (doi:10.2174/1568026616666160413140502) (PMID:27072703)

Laing, R., Maitland, K., Lecova, L., Skuce, P. J., Tait, A., and Devaney, E. (2016) Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use. International Journal for Parasitology, (doi:10.1016/j.ijpara.2016.03.010) (PMID:27179994) (Early Online Publication)

2015

Britton, C., Winter, A. D., Marks, N. D., Gu, H., McNeilly, T. N., Gillan, V., and Devaney, E. (2015) Application of small RNA technology for improved control of parasitic helminths. Veterinary Parasitology, 212(1-2), pp. 47-53. (doi:10.1016/j.vetpar.2015.06.003) (PMID:26095949) (PMCID:PMC4535316)

Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi:10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)

2014

Devaney, E. (2014) Parasites, probiotics, and piglets: a novel approach to IBD. Molecular Therapy, 22(10), pp. 1722-1723. (doi:10.1038/mt.2014.168)

Britton, C., Winter, A. D., Gillan, V., and Devaney, E. (2014) microRNAs of parasitic helminths – identification, characterization and potential as drug targets. International Journal for Parasitology: Drugs and Drug Resistance, 4(2), pp. 85-94. (doi:10.1016/j.ijpddr.2014.03.001)

Gillan, V., and Devaney, E. (2014) Nematode Hsp90: highly conserved but functionally diverse. Parasitology, 141(9), pp. 1-13. (doi:10.1017/S0031182014000304) (PMID:24721950)

Gillan, V., O’Neill, K., Maitland, K., Sverdrup, F. M., and Devaney, E. (2014) A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes. PLoS Neglected Tropical Diseases, 8(2), e2699. (doi:10.1371/journal.pntd.0002699)

2013

Devaney, E. (2013) Genetic and genomic approaches to understanding drug resistance in parasites. Parasitology, 140(12), pp. 1451-1454. (doi:10.1017/S0031182013001212)

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi:10.1186/gb-2013-14-8-r88)

2012

Winter, A.D., Weir, W., Hunt, M., Berriman, M., Gilleard, J.S., Devaney, E., and Britton, C. (2012) Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics, 13, p. 4. (doi:10.1186/1471-2164-13-4)

2011

Devaney, E. (2011) Thermobiotic survival. In: Perry, R.N. and Wharton, D.A. (eds.) Molecular and Physiological Basis of Nematode Survival. CABI: Wallingford, UK, pp. 233-255. ISBN 9781845936877 (doi:10.1079/9781845936877.0233)

2010

Devaney, E.A., Winter, A.D., and Britton, C. (2010) microRNAs: a role in drug resistance in parasitic nematodes? Trends in Parasitology, 26(9), pp. 428-433. (doi:10.1016/j.pt.2010.05.003)

Taldone, T., Gillan, V., Sun, W., Rodina, A., Patel, P., Maitland, K., O'Neill, K., Chiosis, G., and Devaney, E. (2010) Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. PLoS Neglected Tropical Diseases, 4(6), e714. (doi:10.1371/journal.pntd.0000714)

2009

Gillan, V., Maitland, K., McCormack, G., Him, N. A.I.I., and Devaney, E. (2009) Functional genomics of hsp-90 in parasitic and free-living nematodes. International Journal for Parasitology, 39(10), pp. 1071-1081. (doi:10.1016/j.ijpara.2009.02.024)

McNeilly, T.N., Devaney, E., and Matthews, J.B. (2009) Teladorsagia circumcincta in the sheep abomasum: defining the role of dendritic cells in T cell regulation and protective immunity. Parasite Immunology, 31(7), pp. 347-356. (doi:10.1111/j.1365-3024.2009.01110.x)

Him, N.A.I.I.N., Gillan, V., Emes, R.D., Maitland, K., and Devaney, E. (2009) Hsp-90 and the biology of nematodes. BMC Evolutionary Biology, 9(254), pp. 1-13. (doi:10.1186/1471-2148-9-254)

2006

Devaney, E. (2006) Thermoregulation in the life cycle of nematodes. International Journal for Parasitology, 36(6), pp. 641-649. (doi:10.1016/j.ijpara.2006.02.006)

2005

Boitelle, A., Di Lorenzo, C., Scales, H., Devaney, E., Kennedy, M., Garside, P., and Lawrence, C. (2005) Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model. International Journal for Parasitology, 35(7), pp. 765-775. (doi:10.1016/j.ijpara.2005.02.013)

Devaney, E., ONeill, K., Harnett, W., Whitesell, L., and Kinnaird, J. (2005) Hsp90 is essential in the filarial nematode Brugia pahangi. International Journal for Parasitology, 35(6), pp. 627-636. (doi:10.1016/j.ijpara.2005.01.007)

Devaney, E. (2005) The end of the line for hookworm? An update on vaccine development. PLoS Medicine, 2(10), e327. (doi:10.1371/journal.pmed.0020327)

Gillan, V., and Devaney, E. (2005) Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Infection and Immunity, 73, pp. 4034-4042. (doi:10.1128/IAI.73.7.4034-4042.2005)

Gillan, V., Lawrence, R., and Devaney, E. (2005) B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. International Immunology, 17, pp. 373-382. (doi:10.1093/intimm/dxh217)

2004

Gillan, V., and Devaney, E. (2004) Mosquito transmission modulates the immune response in mice infected with the L3 of Brugia pahangi. Parasite Immunology, 26, pp. 359-363.

Kinnaird, J., Maitland, K., Walker, G., Wheatley, I., Thompson, F., and Devaney, E. (2004) HRP-2, a heterogeneous nuclear ribonucleoprotein, is essential for embryogenesis and oogenesis in Caenorhabditis elegans. Experimental Cell Research, 298, pp. 418-430. (doi:10.1016/j.yexcr.2004.04.043)

Stepek, G., Houston, K., Goodridge, H., Devaney, E., and Harnett, W. (2004) Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitology, 128, pp. 91-98. (doi:10.1017/S0031182003004220)

2003

Boitelle, A., Scales, H., Di Lorenzo, C., Devaney, E., Kennedy, M., Garside, P., and Lawrence, C. (2003) Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system. Journal of Immunology, 171, pp. 447-454.

OConnor, R., Jenson, J., Osborne, J., and Devaney, E. (2003) An enduring association? Microfilariae and immunosupression in lymphatic filariasis. Trends in Parasitology, 19(12), pp. 565-570. (doi:10.1016/j.pt.2003.09.017)

Walker, G., Thompson, F., Brawley, A., Scanlon, T., and Devaney, E. (2003) Heat shock factor functions at the convergence of the stress response and developmental pathways in Caenorhabditis elegans. FASEB Journal, 17, p. 1960. (doi:10.1096/fj.03-0164fje)

2002

Emes, R., Thompson, F., Moore, J., Zang, X., and Devaney, E. (2002) Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi. International Journal for Parasitology, 32(4), pp. 415-424.

Akue, J., and Devaney, E. (2002) Transmission intensity affects both antigen-specific and nonspecific T-cell proliferative responses in Loa loa infection. Infection and Immunity, 70, pp. 1475-1480. (doi:10.1128/IAI.70.3.1475-1480.2002)

Akue, J., Devaney, E., Wahl, G., and Moukana, H. (2002) Expression of filarial-specific IgG subclasses under different transmission intensities in a region endemic for loiasis. American Journal of Tropical Medicine and Hygiene, 66, pp. 245-250.

Balmer, P., and Devaney, E. (2002) NK T cells are a source of early interleukin-4 following infection with third-stage larvae of the Filarial nematode Brugia pahangi. Infection and Immunity, 70, pp. 2215-2219. (doi:10.1128/IAI.70.4.2215-2219.2002)

Devaney, E., Gillan, V., Wheatley, I., Jenson, J., OConnor, R., and Balmer, P. (2002) Interleukin-4 influences the production of microfilariae in a mouse model of Brugia infection. Parasite Immunology, 24, pp. 29-37.

Jenson, J., OConnor, R., Osborne, J., and Devaney, E. (2002) Infection with Brugia microfilariae induces apoptosis of CD4(+) T lymphocytes: a mechanism of immune unresponsiveness in filariasis. European Journal of Immunology, 32, pp. 858-867.

OConnor, R., and Devaney, E. (2002) Nitric oxide limits the expansion of antigen-specific T cells in mice infected with the microfilariae of Brugia pahangi. Infection and Immunity, 70, pp. 5997-6004. (doi:10.1128/IAI.70.11.5997-6004.2002)

Stepek, G., Auchie, M., Tate, R., Watson, K., Russell, D., Devaney, E., and Harnett, W. (2002) Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific. Parasitology, 125, pp. 155-164. (doi:10.1017/S0031182002001920)

Thompson, F., Britton, C., Wheatley, I., Maitland, K., Walker, G., Anant, S., Davidson, N., and Devaney, E. (2002) Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Biochemical Journal, 365, pp. 99-107.

2001

Devaney, E., and Yazdanbakhsh, M. (2001) Prospects and challenges in lymphatic filariasis. Parasite Immunology, 23(7), pp. 323-325. (doi:10.1046/j.1365-3024.2001.00393.x)

Hunter, S., Thompson, F., Tetley, L., and Devaney, E. (2001) Temperature is a cue for gene expression in the post-infective L3 of the parasitic nematode Brugia pahangi. Molecular and Biochemical Parasitology, 112, pp. 1-9.

Lawrence, R., and Devaney, E. (2001) Lymphatic filariasis: parallels between the immunology of infection in humans and mice. Parasite Immunology, 23, pp. 353-361.

Thompson, F., Cockroft, A., Wheatley, I., Britton, C., and Devaney, E. (2001) Heat shock and developmental expression of hsp83 in the filarial nematode Brugia pahangi. European Journal of Biochemistry, 268, pp. 5808-5815.

2000

O'Connor, R.A., Jenson, J.S., and Devaney, E. (2000) NO contributes to proliferative suppression in a murine model of filariasis. Infection and Immunity, 68(11), pp. 6101-6107.

Moore, J., Tetley, L., and Devaney, E. (2000) Identification of abundant mRNAs from the third stage larvae of the parasitic nematode, ostertagia ostertagi. Biochemical Journal, 347(3), pp. 763-770.

1999

Moore, J., and Devaney, E. (1999) Cloning and characterization of two nuclear receptors from the filarial nematode Brugia pahangi. Biochemical Journal, 344(1), pp. 245-252.

Hunter, S.J., Martin, S.A., Thompson, F.J., Tetley, L., and Devaney, E. (1999) The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi. Parasitology, 119(2), pp. 189-198. (doi:10.1017/S0031182099004576)

Osborne, J., and Devaney, E. (1999) Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi. Infection and Immunity, 67(4), pp. 1599-1605.

1998

Osborne, J., and Devaney, E. (1998) The L3 of Brugia induces a Th2-polarized response following activation of an IL-4-producing CD4-CD8- alphabeta T cell population. International Immunology, 10(10), pp. 1583-1590. (doi:10.1093/intimm/10.10.1583)

Pennock, J.L., Behnke, J.M., Bickle, Q.D., Devaney, E., Grencis, R.K., Isaac, R.E., Joshua, G.W., Selkirk, M.E., Zhang, Y., and Meyer, D.J. (1998) Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi. Biochemical Journal, 335(3), pp. 495-498.

This list was generated on Fri Dec 9 07:38:49 2016 GMT.
Number of items: 51.

Articles

Kinnaird, J. H., Singh, M., Gillan, V., Weir, W., Calder, E. D.D., Hostettler, I., Tatu, U., and Devaney, E. (2016) Characterisation of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata. Cellular Microbiology, (doi:10.1111/cmi.12669) (PMID:27649068) (Early Online Publication)

Bilsland, E., Bean, D. M., Devaney, E., and Oliver, S. G. (2016) Yeast-based high-throughput screens to identify novel compounds active against Brugia malayi. PLoS Neglected Tropical Diseases, 10(1), e0004401. (doi:10.1371/journal.pntd.0004401) (PMID:26812604) (PMCID:PMC4727890)

Devaney, E., and Gillan, V. (2016) Hsp90 inhibitors in parasitic nematodes: prospects and challenges. Current Topics in Medicinal Chemistry, 16(25), pp. 2805-2811. (doi:10.2174/1568026616666160413140502) (PMID:27072703)

Laing, R., Maitland, K., Lecova, L., Skuce, P. J., Tait, A., and Devaney, E. (2016) Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use. International Journal for Parasitology, (doi:10.1016/j.ijpara.2016.03.010) (PMID:27179994) (Early Online Publication)

Britton, C., Winter, A. D., Marks, N. D., Gu, H., McNeilly, T. N., Gillan, V., and Devaney, E. (2015) Application of small RNA technology for improved control of parasitic helminths. Veterinary Parasitology, 212(1-2), pp. 47-53. (doi:10.1016/j.vetpar.2015.06.003) (PMID:26095949) (PMCID:PMC4535316)

Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi:10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)

Devaney, E. (2014) Parasites, probiotics, and piglets: a novel approach to IBD. Molecular Therapy, 22(10), pp. 1722-1723. (doi:10.1038/mt.2014.168)

Britton, C., Winter, A. D., Gillan, V., and Devaney, E. (2014) microRNAs of parasitic helminths – identification, characterization and potential as drug targets. International Journal for Parasitology: Drugs and Drug Resistance, 4(2), pp. 85-94. (doi:10.1016/j.ijpddr.2014.03.001)

Gillan, V., and Devaney, E. (2014) Nematode Hsp90: highly conserved but functionally diverse. Parasitology, 141(9), pp. 1-13. (doi:10.1017/S0031182014000304) (PMID:24721950)

Gillan, V., O’Neill, K., Maitland, K., Sverdrup, F. M., and Devaney, E. (2014) A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes. PLoS Neglected Tropical Diseases, 8(2), e2699. (doi:10.1371/journal.pntd.0002699)

Devaney, E. (2013) Genetic and genomic approaches to understanding drug resistance in parasites. Parasitology, 140(12), pp. 1451-1454. (doi:10.1017/S0031182013001212)

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi:10.1186/gb-2013-14-8-r88)

Winter, A.D., Weir, W., Hunt, M., Berriman, M., Gilleard, J.S., Devaney, E., and Britton, C. (2012) Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics, 13, p. 4. (doi:10.1186/1471-2164-13-4)

Devaney, E.A., Winter, A.D., and Britton, C. (2010) microRNAs: a role in drug resistance in parasitic nematodes? Trends in Parasitology, 26(9), pp. 428-433. (doi:10.1016/j.pt.2010.05.003)

Taldone, T., Gillan, V., Sun, W., Rodina, A., Patel, P., Maitland, K., O'Neill, K., Chiosis, G., and Devaney, E. (2010) Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. PLoS Neglected Tropical Diseases, 4(6), e714. (doi:10.1371/journal.pntd.0000714)

Gillan, V., Maitland, K., McCormack, G., Him, N. A.I.I., and Devaney, E. (2009) Functional genomics of hsp-90 in parasitic and free-living nematodes. International Journal for Parasitology, 39(10), pp. 1071-1081. (doi:10.1016/j.ijpara.2009.02.024)

McNeilly, T.N., Devaney, E., and Matthews, J.B. (2009) Teladorsagia circumcincta in the sheep abomasum: defining the role of dendritic cells in T cell regulation and protective immunity. Parasite Immunology, 31(7), pp. 347-356. (doi:10.1111/j.1365-3024.2009.01110.x)

Him, N.A.I.I.N., Gillan, V., Emes, R.D., Maitland, K., and Devaney, E. (2009) Hsp-90 and the biology of nematodes. BMC Evolutionary Biology, 9(254), pp. 1-13. (doi:10.1186/1471-2148-9-254)

Devaney, E. (2006) Thermoregulation in the life cycle of nematodes. International Journal for Parasitology, 36(6), pp. 641-649. (doi:10.1016/j.ijpara.2006.02.006)

Boitelle, A., Di Lorenzo, C., Scales, H., Devaney, E., Kennedy, M., Garside, P., and Lawrence, C. (2005) Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model. International Journal for Parasitology, 35(7), pp. 765-775. (doi:10.1016/j.ijpara.2005.02.013)

Devaney, E., ONeill, K., Harnett, W., Whitesell, L., and Kinnaird, J. (2005) Hsp90 is essential in the filarial nematode Brugia pahangi. International Journal for Parasitology, 35(6), pp. 627-636. (doi:10.1016/j.ijpara.2005.01.007)

Devaney, E. (2005) The end of the line for hookworm? An update on vaccine development. PLoS Medicine, 2(10), e327. (doi:10.1371/journal.pmed.0020327)

Gillan, V., and Devaney, E. (2005) Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Infection and Immunity, 73, pp. 4034-4042. (doi:10.1128/IAI.73.7.4034-4042.2005)

Gillan, V., Lawrence, R., and Devaney, E. (2005) B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. International Immunology, 17, pp. 373-382. (doi:10.1093/intimm/dxh217)

Gillan, V., and Devaney, E. (2004) Mosquito transmission modulates the immune response in mice infected with the L3 of Brugia pahangi. Parasite Immunology, 26, pp. 359-363.

Kinnaird, J., Maitland, K., Walker, G., Wheatley, I., Thompson, F., and Devaney, E. (2004) HRP-2, a heterogeneous nuclear ribonucleoprotein, is essential for embryogenesis and oogenesis in Caenorhabditis elegans. Experimental Cell Research, 298, pp. 418-430. (doi:10.1016/j.yexcr.2004.04.043)

Stepek, G., Houston, K., Goodridge, H., Devaney, E., and Harnett, W. (2004) Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitology, 128, pp. 91-98. (doi:10.1017/S0031182003004220)

Boitelle, A., Scales, H., Di Lorenzo, C., Devaney, E., Kennedy, M., Garside, P., and Lawrence, C. (2003) Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system. Journal of Immunology, 171, pp. 447-454.

OConnor, R., Jenson, J., Osborne, J., and Devaney, E. (2003) An enduring association? Microfilariae and immunosupression in lymphatic filariasis. Trends in Parasitology, 19(12), pp. 565-570. (doi:10.1016/j.pt.2003.09.017)

Walker, G., Thompson, F., Brawley, A., Scanlon, T., and Devaney, E. (2003) Heat shock factor functions at the convergence of the stress response and developmental pathways in Caenorhabditis elegans. FASEB Journal, 17, p. 1960. (doi:10.1096/fj.03-0164fje)

Emes, R., Thompson, F., Moore, J., Zang, X., and Devaney, E. (2002) Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi. International Journal for Parasitology, 32(4), pp. 415-424.

Akue, J., and Devaney, E. (2002) Transmission intensity affects both antigen-specific and nonspecific T-cell proliferative responses in Loa loa infection. Infection and Immunity, 70, pp. 1475-1480. (doi:10.1128/IAI.70.3.1475-1480.2002)

Akue, J., Devaney, E., Wahl, G., and Moukana, H. (2002) Expression of filarial-specific IgG subclasses under different transmission intensities in a region endemic for loiasis. American Journal of Tropical Medicine and Hygiene, 66, pp. 245-250.

Balmer, P., and Devaney, E. (2002) NK T cells are a source of early interleukin-4 following infection with third-stage larvae of the Filarial nematode Brugia pahangi. Infection and Immunity, 70, pp. 2215-2219. (doi:10.1128/IAI.70.4.2215-2219.2002)

Devaney, E., Gillan, V., Wheatley, I., Jenson, J., OConnor, R., and Balmer, P. (2002) Interleukin-4 influences the production of microfilariae in a mouse model of Brugia infection. Parasite Immunology, 24, pp. 29-37.

Jenson, J., OConnor, R., Osborne, J., and Devaney, E. (2002) Infection with Brugia microfilariae induces apoptosis of CD4(+) T lymphocytes: a mechanism of immune unresponsiveness in filariasis. European Journal of Immunology, 32, pp. 858-867.

OConnor, R., and Devaney, E. (2002) Nitric oxide limits the expansion of antigen-specific T cells in mice infected with the microfilariae of Brugia pahangi. Infection and Immunity, 70, pp. 5997-6004. (doi:10.1128/IAI.70.11.5997-6004.2002)

Stepek, G., Auchie, M., Tate, R., Watson, K., Russell, D., Devaney, E., and Harnett, W. (2002) Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific. Parasitology, 125, pp. 155-164. (doi:10.1017/S0031182002001920)

Thompson, F., Britton, C., Wheatley, I., Maitland, K., Walker, G., Anant, S., Davidson, N., and Devaney, E. (2002) Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Biochemical Journal, 365, pp. 99-107.

Devaney, E., and Yazdanbakhsh, M. (2001) Prospects and challenges in lymphatic filariasis. Parasite Immunology, 23(7), pp. 323-325. (doi:10.1046/j.1365-3024.2001.00393.x)

Hunter, S., Thompson, F., Tetley, L., and Devaney, E. (2001) Temperature is a cue for gene expression in the post-infective L3 of the parasitic nematode Brugia pahangi. Molecular and Biochemical Parasitology, 112, pp. 1-9.

Lawrence, R., and Devaney, E. (2001) Lymphatic filariasis: parallels between the immunology of infection in humans and mice. Parasite Immunology, 23, pp. 353-361.

Thompson, F., Cockroft, A., Wheatley, I., Britton, C., and Devaney, E. (2001) Heat shock and developmental expression of hsp83 in the filarial nematode Brugia pahangi. European Journal of Biochemistry, 268, pp. 5808-5815.

O'Connor, R.A., Jenson, J.S., and Devaney, E. (2000) NO contributes to proliferative suppression in a murine model of filariasis. Infection and Immunity, 68(11), pp. 6101-6107.

Moore, J., Tetley, L., and Devaney, E. (2000) Identification of abundant mRNAs from the third stage larvae of the parasitic nematode, ostertagia ostertagi. Biochemical Journal, 347(3), pp. 763-770.

Moore, J., and Devaney, E. (1999) Cloning and characterization of two nuclear receptors from the filarial nematode Brugia pahangi. Biochemical Journal, 344(1), pp. 245-252.

Hunter, S.J., Martin, S.A., Thompson, F.J., Tetley, L., and Devaney, E. (1999) The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi. Parasitology, 119(2), pp. 189-198. (doi:10.1017/S0031182099004576)

Osborne, J., and Devaney, E. (1999) Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi. Infection and Immunity, 67(4), pp. 1599-1605.

Osborne, J., and Devaney, E. (1998) The L3 of Brugia induces a Th2-polarized response following activation of an IL-4-producing CD4-CD8- alphabeta T cell population. International Immunology, 10(10), pp. 1583-1590. (doi:10.1093/intimm/10.10.1583)

Pennock, J.L., Behnke, J.M., Bickle, Q.D., Devaney, E., Grencis, R.K., Isaac, R.E., Joshua, G.W., Selkirk, M.E., Zhang, Y., and Meyer, D.J. (1998) Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi. Biochemical Journal, 335(3), pp. 495-498.

Book Sections

Devaney, E. (2011) Thermobiotic survival. In: Perry, R.N. and Wharton, D.A. (eds.) Molecular and Physiological Basis of Nematode Survival. CABI: Wallingford, UK, pp. 233-255. ISBN 9781845936877 (doi:10.1079/9781845936877.0233)

This list was generated on Fri Dec 9 07:38:49 2016 GMT.

Funded KTN BBSRC CASE PhD in vet parasitology
Closing date 1 March 2015

Markers of anthelmintic resistance in gastro-intestinal parasites of ruminants

Stipend: £16, 613 pa (baseline at 2014/15 rate), with added enhancement for a veterinary graduate
Start date: 1st October
Supervisors: Prof Eileen Devaney and Dr Roz Laing

Outline:

Grazing livestock are infected by multiple species of gastrointestinal (GI) worms. These ubiquitous parasites compromise the health and welfare of their hosts and severely constrain productivity. Current control practices are inadequate, relying on a small number of anthelmintics, which are now compromised by anthelmintic resistance (AR). In the sheep industry, AR is widespread and there are well-documented cases of UK farms harbouring multi-drug-resistant worms, which have been forced to abandon sheep rearing. Farmers have few alternatives however, with no commercially available vaccine and only two new classes of anthelmintic developed in the last 30 years. While the consequences of AR are currently most severe in the sheep industry, resistance is of increasing concern in the dairy and beef sectors. Cattle are infected with a number of GI parasites, which are closely-related to those in sheep and are treated with the same few drugs. This situation is potentially a ticking bomb due to the lack of sensitive diagnostic tests that can detect AR at an early stage.

This PhD project will integrate with a larger BBSRC-funded project, which is using novel genomic approaches to understand the mechanisms of AR in GI parasites. A major focus of the PhD is to identify genetic markers of AR in the sheep nematode Teladorsagia circumcincta with a view to developing a sensitive diagnostic test for AR in this species and related parasites of sheep and cattle. Genome-wide sequencing approaches will be used to genotype T. circumcincta populations from UK farms with known resistance problems. Single nucleotide polymorphisms (SNPs) will be identified in the populations, pre- and post-anthelmintic treatment, and used to identify regions of the genome under selection. These loci will be further investigated as part of the larger project to identify the mutations conferring resistance. SNPs that are associated with AR will be validated in a previously generated biobank of UK farm parasites and developed as molecular markers.


The availability of molecular markers for AR will allow better surveillance, diagnosis and intervention at a suitably early stage (before clinical failure). Importantly, it will allow accurate evaluation of methods aimed at restricting the spread of AR and preserving the effectiveness of currently licensed anthelmintics. An understanding of the mechanisms underlying AR may also reveal opportunities to attenuate/reverse resistance and to design more effective formulations or treatment strategies. These findings will be relayed to the farming community in collaboration with EBLEX, via industry-led working groups SCOPS (Sustainable Control of Parasites of Sheep) and COWS (Control of Worms Sustainably).


This PhD project applies state-of-the-art sequencing technologies to address an important problem for animal health and food production. The work is multi-disciplinary and, as such, will provide significant training in a number of important areas including veterinary fieldwork, molecular biology, next generation sequencing, population genomics, bioinformatics and knowledge exchange. Skills acquired during the PhD will be applicable to many other systems and different career pathways. The student will integrate with an experienced, enthusiastic and supportive team of researchers who will provide expertise and training in all areas.

How to apply

Funding Notes:
The project is funded by a KTN BBSRC CASE Award for a period of 4 years and the student will be required to spend a period greater than 3 months duration working with the industrial supervisor. Candidates should have a 1st or 2:1 in molecular biology, genetics or related subject, or be a veterinary graduate.