2012

Stephens, N.A., Kieft, R., MacLeod, A., and Hajduk, S.L. (2012) Trypanosome resistance to human innate immunity: targeting Achilles’ heel. Trends in Parasitology, 28 (12). pp. 539-545. ISSN 1471-4922 (doi:10.1016/j.pt.2012.09.002)

Bullard, W., Kieft, R., Capewell, P., Veitch, N.J., MacLeod, A., and Hajduk, S.L. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum. Virulence, 3 (1). pp. 72-76. ISSN 2150-5594 (doi:10.4161/viru.3.1.18295)

Kieft, R., Stephens, N.A., Capewell, P., MacLeod, A., and Hajduk, S.L. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Molecular and Biochemical Parasitology, 183 (1). pp. 8-14. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2011.12.004)

2011

Kaboré, J., Koffi, M., Bucheton, B., MacLeod, A., Duffy, C., Ilboudo, H., Camara, M., De Meeûs, T., Belem, A.M.G., and Jamonneau, V. (2011) First evidence that parasite infecting apparent aparasitemic serological suspects in human African trypanosomiasis are Trypanosoma brucei gambiense and are similar to those found in patients. Infection, Genetics and Evolution, 11 (6). pp. 1250-1255. ISSN 1567-1348 (doi:10.1016/j.meegid.2011.04.014)

Kaboré, J., MacLeod, A., Jamonneau, V., Ilboudo, H., Duffy, C., Camara, M., Camara, O., Belem, A.M.G., Bucheton, B., and De Meeûs, T. (2011) Population genetic structure of Guinea Trypanosoma brucei gambiense isolates according to host factors. Infection, Genetics and Evolution, 11 (5). pp. 1129-35. ISSN 1567-1348 (doi:10.1016/j.meegid.2011.04.011)

Bucheton, B., MacLeod, A., and Jamonneau, V. (2011) Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections. Parasite Immunology, 33 (8). pp. 438-447. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2011.01287.x)

Capewell, P., Veitch, N.J., Turner, C.M.R., Raper, J., Berriman, M., Hajduk, S.L., and MacLeod, A. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1. PLoS Neglected Tropical Diseases, 5 (9). e1287. ISSN 1935-2735 (doi:10.1371/journal.pntd.0001287)

Morrison, L.J., and MacLeod, A. (2011) Editorial: African trypanosomiasis. Parasite Immunology, 33 (8). pp. 421-422. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2011.01302.x)

Tait, A, Morrison, L.J., Duffy, C.W., Cooper, A., Turner, C.M.R., and MacLeod, A. (2011) Trypanosome genetics: Populations, phenotypes and diversity. Veterinary Parasitology, 181 (1). pp. 61-68. ISSN 0304-4017 (doi:10.1016/j.vetpar.2011.04.024)

2010

Jackson, A. et al. (2010) The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis. PLoS Neglected Tropical Diseases, 4 (4). e658. ISSN 1935-2727 (doi:10.1371/journal.pntd.0000658)

Morrison, L.J., McLellan, S., Sweeney, L., Chan, C.N., MacLeod, A., Tait, A., and Turner, C.M.R. (2010) Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection. Infection and Immunity, 78 (3). pp. 1096-1108. ISSN 0019-9567 (doi:10.1128/IAI.00943-09)

Veitch, N.J., Johnson, P., Trivedi, U., Terry, S., Wildridge, D., and MacLeod, A. (2010) Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes. BMC Genomics, 11 (1). p. 124. ISSN 1471-2164 (doi:10.1186/1471-2164-11-124)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9 (2). pp. 336-343. ISSN 1535-9778

Harrington, J. M., Widener, J., Stephens, N., Johnson, T., Francia, M., Capewell, P., MacLeod, A., and Hajduk, S. L. (2010) The Plasma Membrane of Bloodstream-form African Trypanosomes Confers Susceptibility and Specificity to Killing by Hydrophobic Peptides. Journal of Biological Chemistry, 285 (37). pp. 28659-28666. ISSN 0021-9258 (doi:10.1074/jbc.M110.151886)

Kieft, R., Capewell, P., Turner, C.M.R., Veitch, N.J., MacLeod, A., and Hajduk, S. (2010) Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proceedings of the National Academy of Sciences, 107 (37). pp. 16137-16141. ISSN 0027-8424 (doi:10.1073/pnas.1007074107)

2009

Morrison, L.J., Tait, A., McLellan, S., Sweeney, L., Turner, C.M.R., and MacLeod, A. (2009) A major genetic locus in Trypanosoma brucei is a determinant of host pathology. PLoS Neglected Tropical Diseases, 3 (12). e557. ISSN 1935-2727 (doi:10.1371/journal.pntd.0000557)

Morrison, L.J. et al. (2009) Discovery of mating in the major African livestock pathogen Trypanosoma congolense. PLoS ONE, 4 (5). e5564. ISSN 1932-6203 (doi:10.1371/journal.pone.0005564)

2008

Cooper, A., Tait, A., Sweeney, L., Tweedie, A., Morrison, L., Turner, C.M.R., and MacLeod, A. (2008) Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map. Genome Biology, 9 (6). R103. ISSN 1465-6906 (doi:10.1186/gb-2008-9-6-r103)

Morrison, L.J., Mallon, M.E., Smith, H.V., MacLeod, A., Xiao, L., and Tait, A. (2008) The population structure of the Cryptosporidium parvum population in Scotland: a complex picture. Infection, Genetics and Evolution, 8 (2). pp. 121-129. ISSN 1567-1348 (doi:10.1016/j.meegid.2007.10.010)

Morrison, L., Tait, A., McCormack, G., Sweeney, L., Black, A., Truc, P, Likeufack, A, Turner, C.M.R., and MacLeod, A. (2008) Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation. Infection, Genetics and Evolution, 8 (6). pp. 847-854. ISSN 1567-1348 (doi:10.1016/j.meegid.2008.08.005)

2007

MacLean, L., Odiit, M., MacLeod, A., Morrison, L., Sweeney, L., Cooper, A., Kennedy, P.G.E., and Sternberg, J.M. (2007) Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response. Journal of Infectious Diseases, 196 (11). pp. 1620-1628. ISSN 0022-1899 (doi:10.1086/522011)

Morrison, L.J., McCormack, G., Sweeney, L., Likeufack, A.C.L., Truc, P., Turner, C.M.R., Tait, A., and MacLeod, A. (2007) The use of Multiple Displacement Amplification to increase the detection and genotyping of Trypanosoma samples immobilised on FTA filters. American Journal of Tropical Medicine and Hygiene, 76 (6). pp. 1132-1137. ISSN 0002-9637

MacLean, L, Odiit, M, MacLeod, A, Morrison, L, Sweeney, L, Cooper, A, Kennedy, PGE, and Sternberg, JM (2007) Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-gamma response. Journal of Infectious Diseases, 196 (s3). pp. 1620-1628. (doi:10.1086/522011)

MacLeod, A., Turner, C.M.R., and Tait, A. (2007) The system of genetic exchange in Trypanosoma brucei and other trypanosomatids. In: Barry, D., McCulloch, R., Mottram, J. and Acosta-Serrano, A. (eds.) Trypanosomes: after the genome. Horizon Press, pp. 71-90. ISBN 9781904933274

Morrison, LJ, McCormack, G, Sweeney, L, Likeufack, ACL, Truc, P, Turner, CM, Tait, A, and MacLeod, A (2007) Use of multiple displacement amplification to increase the detection and genotyping of Trypanosoma species samples immobilized on FTA filters. American Journal of Tropical Medicine and Hygiene, 76 . pp. 1132-1137.

Tait, A., MacLeod, A., Tweedie, A., Masiga, D., and Turner, C.M.R. (2007) Genetic exchange in Trypanosoma brucei: Evidence for mating prior to metacyclic stage development. Molecular and Biochemical Parasitology, 151 . pp. 133-136. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2006.10.009)

2006

Balmer, O, Palma, C, Macleod, A, and Caccone, A (2006) Characterization of di-, tri- and tetranucleotide microsatellite markers with perfect repeats for Trypanosoma brucei and related species. Molecular Ecology Notes, 6 . pp. 508-510. (doi:10.1111/j.1471-8286.2006.01297.x)

2005

MacLeod, A., Tweedie, A., McLellan, S., Taylor, S., Hall, N., Berriman, M., El-Sayed, N.M., Hope, M., Turner, C.M.R., and Tait, A. (2005) The genetic map and comparative analysis with the physical map of Trypanosoma brucei. Nucleic Acids Research, 33 (21). pp. 6688-6693. ISSN 0305-1048 (doi:10.1093/nar/gki980)

Berriman, M. et al. (2005) The genome of the African trypanosome Trypanosoma brucei. Science, 309 (5733). pp. 416-422. ISSN 0036-8075 (doi:10.1126/science.1112642)

Smith, H.V., Nichols, R.A., Mallon, M., MacLeod, A., Tait, A., Reilly, W.J., Browning, L.M., Gray, D., Reid, S.W.J., and Wastling, J.M. (2005) Natural Cryptosporidium hominis infections in Scottish cattle. Veterinary Record, 156 (22). pp. 710-711. ISSN 0042-4900

MacLeod, A, Tweedie, A, McLellan, S, Taylor, S, Cooper, A, Sweeney, L, Turner, CMR, and Tait, A (2005) Allelic segregation and independent assortment in T-brucei crosses: Proof that the genetic system is Mendelian and involves meiosis. Molecular and Biochemical Parasitology, 143 . pp. 12-19. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2005.04.009)

MacLeod, A., Tweedie, A., McLellan, S., Taylor, S., Cooper, A., Sweeney, L., Turner, C.M.R., and Tait, A. (2005) Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis. Molecular and Biochemical Parasitology, 143 (1). pp. 12-19. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2005.04.009)

Tait, A., MacLeod, A., Tweedie, A., Masiga, D., and Turner, C.M.R. (2005) Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development. Molecular and Biochemical Parasitology, 151 (1). pp. 133-136. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2006.10.009)

2004

Turner, C.M.R., McLellan, S., Lindergard, L.A.G., Bisoni, L., Tait, A., and MacLeod, A. (2004) Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression. Parasitology, 129 (4). pp. 445-454. ISSN 0031-1820 (doi:10.1017/S0031182004005906)

Turner, CMR, McLellan, S, Lindergard, LAG, Bisoni, L, Tait, A, and MacLeod, A (2004) Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression. Parasitology, 129 . pp. 445-454. (doi:10.1017/S0031182004005906)

2003

El-Sayed, NMA et al. (2003) The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic Acids Research, 31 . pp. 4856-4863. (doi:10.1093/nar/gkg673)

Mallon, M, MacLeod, A, Wastling, J, Smith, H, Reilly, B, and Tait, A (2003) Population structures and the role of genetic exchange in the zoonotic pathogen Cryptosporidium parvum. Journal of Molecular Evolution, 56 . pp. 407-417. (doi:10.1007/s00239-002-2412-3)

2002

Tait, A, Masiga, D, Ouma, J, MacLeod, A, Sasse, J, Melville, S, Lindegard, G, McIntosh, A, and Turner, M (2002) Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences, 357 . pp. 89-99. ISSN 0962-8436 (doi:10.1098/rstb.2001.1050)

2001

MacLeod, A, Tait, A, and Turner, CMR (2001) The population genetics of Trypanosoma brucei and the origin of human infectivity. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences, 356 . pp. 1035-1044. ISSN 0962-8436

MacLeod, A, Welburn, S, Maudlin, I, Turner, CMR, and Tait, A (2001) Evidence for multiple origins of human infectivity in Trypanosoma brucei revealed by minisatellite variant repeat mapping. Journal of Molecular Evolution, 52 . pp. 290-301.