Dr Sally Pimlott

Honorary Clinical Senior Lecturer (School of Medicine, Dentistry & Nursing)

PET Radiopharamceutical Production Unit, West of Scotland PET Centre, Gartnavel General Hospital, 1053 Great Western Rd, G12 0YN

Import to contacts

https://orcid.org/0000-0002-8396-3392

Publications

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Number of items: 82.

2024

McErlain, H., Andrews, M. J., Watson, A. J.B., Pimlott, S. L. and Sutherland, A. (2024) Ligand-enabled copper-mediated radioiodination of arenes. Organic Letters, 26(7), pp. 1528-1532. (doi: 10.1021/acs.orglett.4c00356) (PMID:38335124) (PMCID:PMC10897930)

Knyzeliene, A., Wimberley, C., MacAskill, M. G., Alcaide-Corral, C. J., Morgan, T. E. F., Henry, M. C., Lucatelli, C., Pimlott, S. L. , Sutherland, A. and Tavares, A. A. S. (2024) Sexually dimorphic murine brain uptake of the 18 kDa translocator protein PET radiotracer [18F]LW223. Brain Communications, fcae008. (doi: 10.1093/braincomms/fcae008) (In Press)

2023

Knyzeliene, A., MacAskill, M. G., Alcaide-Corral, C. J., Morgan, T. E., Henry, M. C., Lucatelli, C., Pimlott, S. L. , Sutherland, A. and Tavares, A. A.S. (2023) [18F]LW223 has low non-displaceable binding in murine brain, enabling high sensitivity TSPO PET imaging. Journal of Cerebral Blood Flow and Metabolism, (doi: 10.1177/0271678x231205661) (PMID:37795635) (Early Online Publication)

2021

MacAskill, M. G., Wimberley, C., Morgan, T. E. F., Alcaide‑Corral, C. J., Newby, D. E., Lucatelli, C., Sutherland, A. , Pimlott, S. L. and Tavares, A. A. S. (2021) Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain. European Journal of Nuclear Medicine and Molecular Imaging, 49, pp. 137-145. (doi: 10.1007/S00259-021-05482-1) (PMID:34338808) (PMCID:PMC8712302)

MacAskill, M. G. et al. (2021) Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism. Journal of Nuclear Medicine, 62(4), pp. 536-544. (doi: 10.2967/jnumed.120.243600) (PMID:32859708) (PMCID:PMC8049364)

Welch, A., Tavares, A. A. S., Pimlott, S. and Sutherland, A. (2021) PET and SPECT in drug development. In: Abraham, D. J. (ed.) Burger's Medicinal Chemistry, Drug Discovery and Development. Wiley. ISBN 9780470278154 (doi: 10.1002/0471266949.bmc254.pub2)

2020

Malviya, G. et al. (2020) 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy. EJNMMI Research, 10, 143. (doi: 10.1186/s13550-020-00728-9) (PMID:33237350) (PMCID:PMC7688773)

2019

MacAskill, M. G. et al. (2019) Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer. PLoS ONE, 14(5), e0217515. (doi: 10.1371/journal.pone.0217515) (PMID:31150436) (PMCID:PMC6544349)

Molloy, J. J., O'Rourke, K., Frias, C. P., Sloan, N., West, M. J., Pimlott, S. L. , Sutherland, A. and Watson, A. J.B. (2019) Mechanism of Cu-catalyzed aryl boronic acid halodeboronation using electrophilic halogen: development of a base-catalyzed iododeboronation for radiolabeling applications. Organic Letters, 21(7), pp. 2488-2492. (doi: 10.1021/acs.orglett.9b00942) (PMID:30908055)

2018

O'Rourke, K., Johnstone, E. S., Becker, H. M., Pimlott, S. L. and Sutherland, A. (2018) Exploring the functionalisation of the thieno[2,3-d]pyrimidinedione core: late stage access to highly substituted 5-carboxamide-6-aryl scaffolds. Tetrahedron, 74(30), pp. 4086-4094. (doi: 10.1016/j.tet.2018.06.019)

Zmuda, F., Blair, A., Liuzzi, M. C., Malviya, G. , Chalmers, A. J. , Lewis, D., Sutherland, A. and Pimlott, S. L. (2018) An 18F-labeled poly(ADP-ribose) polymerase positron emission tomography imaging agent. Journal of Medicinal Chemistry, 61(9), pp. 4103-4114. (doi: 10.1021/acs.jmedchem.8b00138) (PMID:29630818) (PMCID:PMC6007963)

Webster, S., O'Rourke, K. M., Fletcher, C., Pimlott, S. L. , Sutherland, A. and Lee, A.-L. (2018) Rapid iododeboronation with and without gold catalysis: application to radiolabelling of arenes. Chemistry: A European Journal, 24(4), pp. 937-943. (doi: 10.1002/chem.201704534) (PMID:29105856) (PMCID:PMC5814724)

Krishnadas, R. , Cooper, S.-A. , Nicol, A., Pimlott, S., Soni, S., Holland, A., McArthur, L. and Cavanagh, J. (2018) Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader–Willi syndrome. British Journal of Psychiatry, 212(1), pp. 57-58. (doi: 10.1192/bjp.2017.7)

2017

Maneuski, D. , Giacomelli, F., Lemaire, C., Pimlott, S. , Plenevaux, A., Owens, J., O'Shea, V. and Luxen, A. (2017) On the use of positron counting for radio-assay in nuclear pharmaceutical production. Applied Radiation and Isotopes, 125, pp. 9-14. (doi: 10.1016/j.apradiso.2017.03.021) (PMID:28390998)

MacAskill, M., Zmuda, F., Lucatelli, C., Dweck, M., Gray, G., Newby, D., Sutherland, A. , Pimlott, S. and Tavares, A. (2017) Binding affinity profiles of isoquinoline carboxamide and phenoxyphenyl acetamide-based TSPO PET ligands in human brain and heart. Journal of Nuclear Medicine, 58(suppl1), p. 478.

Sloan, N. L., Luthra, S. K., McRobbie, G., Pimlott, S. L. and Sutherland, A. (2017) Late stage iodination of biologically active agents using a one-pot process from aryl amines. RSC Advances, 7(86), pp. 54881-54891. (doi: 10.1039/C7RA11860K)

2016

Tarn, M. D., Maneuski, D. , Alexander, R., Brown, N. J., O'Shea, V. , Pimlott, S. L. , Pamme, N. and Archibald, S. J. (2016) Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical Communications, 52(45), pp. 7221-7224. (doi: 10.1039/c6cc00660d) (PMID:27029282)

Cant, A. A., Racys, D. T., Pimlott, S. L. and Sutherland, A. (2016) New reactions for the synthesis of aryl iodides and the generation of single-photon emission computed tomography imaging agents. 24th international isotope society (UK group) symposium, Cambridge, UK, 06 Nov 2015. p. 182. (doi: 10.1002/jlcr.3377)

Racys, D. T., Sharif, S. A.I., Pimlott, S. L. and Sutherland, A. (2016) Silver(I)-catalyzed iodination of Arenes: Tuning the Lewis acidity of N-iodosuccinimide activation. Journal of Organic Chemistry, 81(3), pp. 772-780. (doi: 10.1021/acs.joc.5b02761) (PMID:26795534)

Krishnadas, R. et al. (2016) Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans. Brain, Behavior, and Immunity, 51, pp. 29-38. (doi: 10.1016/j.bbi.2015.08.005) (PMID:26255693)

Pajak, M. Z., Volgyes, D., Pimlott, S. L., Salvador, C. C., Asensi, A. S., McKeown, C., Waldeck, J. and Anderson, K. I. (2016) NEMA NU4-2008 performance evaluation of Albira: a two-ring small-animal PET system using continuous LYSO crystals. Open Medicine Journal, 3, pp. 12-26. (doi: 10.2174/1874220301603010012)

2015

Zmuda, F., Malviya, G. , Blair, A., Boyd, M., Chalmers, A. J. , Sutherland, A. and Pimlott, S. L. (2015) Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo. Journal of Medicinal Chemistry, 58(21), pp. 8683-8693. (doi: 10.1021/acs.jmedchem.5b01324) (PMID:26469301)

Krishnadas, R. , Nicol, A., Sassarini, J., Puri, N.,, Pimlott, S. , Hadley, D., McInnnes, I. and Cavanagh, J. (2015) SPECT Scanning of Brainstem Serotonin Transporter Availability Reveals Association with Circulating Inflammatory Tumour Necrosis Factor. 28th Annual EANM Congress of the European Association of Nuclear Medicine 2015, Hamburg, Germany, 10-14 Oct 2015. S557-S558. (doi: 10.1007/s00259-015-3198-z)

Racys, D. T., Warrilow, C. E., Pimlott, S. L. and Sutherland, A. (2015) Highly regioselective iodination of arenes via iron(III)-catalyzed activation of N-iodosuccinimide. Organic Letters, 17(19), pp. 4782-4785. (doi: 10.1021/acs.orglett.5b02345) (PMID:26394175)

Blair, A., Zmuda, F., Malviya, G. , Chalmers, A. J. , Dewar, D. , Pimlott, S. L. and Sutherland, A. (2015) A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chemical Science, 6(8), pp. 4772-4777. (doi: 10.1039/C5SC01647A)

2014

Morran, D. C. et al. (2014) Targeting mTOR dependency in pancreatic cancer. Gut, 63(9), pp. 1481-1489. (doi: 10.1136/gutjnl-2013-306202) (PMID:24717934) (PMCID:PMC4145424)

Pimlott, S. L. (2014) Radioisotopes for medical imaging. International Journal of Modern Physics A, 29(14), 1441003. (doi: 10.1142/S0217751X14410036)

Sassarini, J., Krishnadas, R. , Cavanagh, J. , Nicol, A., Pimlott, S. L. , Ferrell, W. and Lumsden, M. A. (2014) Venlafaxine alters microvascular perfusion, [123I]-beta-CIT binding and BDI scores in flushing postmenopausal women. Maturitas, 77(3), pp. 267-273. (doi: 10.1016/j.maturitas.2013.12.003)

Hong, Y.T. et al. (2014) Amyloid imaging with carbon 11–labeled pittsburgh compound b for traumatic brain injury. JAMA Neurology, 71(1), pp. 23-31. (doi: 10.1001/jamaneurol.2013.4847) (PMID:24217171) (PMCID:PMC4084932)

Lewis, D. Y., Champion, S. , Wyper, D., Dewar, D. and Pimlott, S. (2014) Assessment of [125I]WYE-230949 as a novel histamine H3 receptor radiopharmaceutical. PLoS ONE, 9(12), e115876. (doi: 10.1371/journal.pone.0115876) (PMID:25542008) (PMCID:PMC4277420)

2013

Cant, A.A., Champion, S. , Bhalla, R., Pimlott, S.L. and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52(30), pp. 7829-7832. (doi: 10.1002/anie.201302800)

Gilfillan, L., Blair, A., Morris, B. , Pratt, J., Schweiger, L., Pimlott, S. and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4(7), pp. 1118-1123. (doi: 10.1039/c3md00110e)

McCluskey, A.G., Mairs, R.J. , Sorensen, A., Robson, T., McCarthy, H.O., Pimlott, S.L. , Babich, J.W., Champion, S. and Boyd, M. (2013) Gamma irradiation and targeted radionuclides enhance the expression of the noradrenaline transporter transgene controlled by the radio-inducible p21^WAF1/CIP1 promoter. Radiation Research, 179(3), pp. 282-292. (doi: 10.1667/RR3030.1)

Blair, A., Stevenson, L., Dewar, D. , Pimlott, S.L. and Sutherland, A. (2013) Structure–activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein. MedChemComm, 4(11), pp. 1461-1466. (doi: 10.1039/c3md00249g)

Blair, A., Pimlott, S. , Schwieger, L. and Sutherland, A. (2013) New PET and SPECT imaging agents for the translocator protein (18 kDa). 245th National Spring Meeting of the American-Chemical-Society (ACS), New Orleans, Louisiana, USA, 07-11 Apr 2013.

2012

Tavares, A. A. S., Jobson, N. K., Dewar, D. , Sutherland, A. , Pimlott, S. L. , Batis, J., Barret, O., Baldwin, R., Seibyl, J. and Tamagnan, G. (2012) Radioiodinated reboxetine analogues for imaging of the norepinephrine transporters in brain using single photon emission computed tomography. 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Baltimore, Maryland, USA, 09-11 Aug 2012. S103-S104. (doi: 10.1038/jcbfm.2012.79)

McCluskey, A.G., Mairs, R.J. , Tesson, M., Pimlott, S.L. , Babich, J.W., Gaze, M.N., Champion, S. and Boyd, M. (2012) Inhibition of poly(ADP-ribose) polymerase enhances the toxicity of 131I-metaiodobenzylguanidine/topotecan combination therapy to cells and xenografts that express the noradrenaline transporter. Journal of Nuclear Medicine, 53(7), pp. 1146-1154. (doi: 10.2967/jnumed.111.095943)

Nicol, A., Krishnadas, R. , Champion, S. , Tamagnan, G., Stehouwer, J.S., Goodman, M.M., Hadley, D. and Pimlott, S.L. (2012) Biodistribution and dosimetry of ¹²³I-mZIENT: a novel ligand for imaging serotonin transporters. European Journal of Nuclear Medicine and Molecular Imaging, 39(5), pp. 786-791. (doi: 10.1007/s00259-011-2056-x)

Sorensen, A.,, Mairs, R.J. , Braidwood, L.,, Joyce, C., Pimlott, S. , Brown, M. and Boyd, M. (2012) In vivo evaluation of a cancer therapy strategy combining HSV1716-mediated oncolysis with gene transfer and targeted radiotherapy. Journal of Nuclear Medicine, 53(4), pp. 647-654. (doi: 10.2967/jnumed.111.090886)

Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J. , Pimlott, S. , Grosset, K.A. and Grosset, D.G. (2012) Serotonergic Function in Early Parkinson's Disease With and Without Depression: A Pilot Study. Association of British Neurologists Annual Meeting 2011, Newcastle, UK, 2011. (doi: 10.1136/jnnp-2011-301993.158)

Cant, A., Bhalla, R., Pimlott, S.L. and Sutherland, A. (2012) Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides. Chemical Communications, 48(33), pp. 3993-3995. (doi: 10.1039/c2cc30956d)

McCluskey, A.G., Mairs, R.J. , Tesson, M., Pimlott, S.L. , Babich, J.W., Gaze, M.N., Champion, S. and Boyd, M. (2012) Inhibition of poly(ADP-ribose) polymerase enhances the toxicity of ¹³¹I-metaiodobenzylguanidine/topotecan combination therapy to cells and xenografts that express the noradrenaline transporter. Journal of Nuclear Medicine, 53(7), pp. 1146-1154. (doi: 10.2967/jnumed.111.095943)

Sorensen, A., Mairs, R.J. , Braidwood, L., Joyce, C., Conner, J., Pimlott, S. , Brown, S.M. and Boyd, M. (2012) Efficacy in vivo of a cancer therapy strategy combining HSV1716 mediated oncolysis with gene transfer and targeted radiotherapy. Mutagenesis, 27(1), pp. 134-135. (doi: 10.1093/mutage/ger068)

Tavares, A.A.S., Jobson, N.K., Dewar, D. , Sutherland, A. , Pimlott, S.L. , Batis, J., Barret, O., Seibyl, J. and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66(11), pp. 923-930. (doi: 10.1002/syn.21585)

Tavares, A.A.S., Lewsey, J. , Dewar, D. and Pimlott, S.L. (2012) Radiotracer properties determined by high performance liquid chromatography: a potential tool for brain radiotracer discovery. Nuclear Medicine and Biology, 39(1), pp. 127-135. (doi: 10.1016/j.nucmedbio.2011.06.011)

2011

Champion, S. , Nicol, A., Krishnadas, R. , Kudej, G., Tamagnan, G., Stehouwer, J.S., Goodman, M.M. and Pimlott, S. (2011) Human biodistribution, dosimetry and brain SPECT imaging with [123I]-mZIENT. 19th International Symposium on Radiopharmaceutical Sciences, Amsterdam, Netherlands, 28 Aug-2 Sep 2011. S299. (doi: 10.1002/jlcr.1925)

Champion, S. , Gross, J., Robichaud, A.J. and Pimlott, S. (2011) Radiosynthesis of 123I-labelled benzimidazoles as novel single-photon emission computed tomography tracers for the histamine H3 receptor. Journal of Labelled Compounds and Radiopharmaceuticals, 54(10), pp. 674-677. (doi: 10.1002/jlcr.1899)

Tavares, A.A.S., Jobson, N.K., Dewar, D. , Sutherland, A. and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity ¹²³I-NKJ64. Nuclear Medicine and Biology, 38(4), pp. 493-500. (doi: 10.1016/j.nucmedbio.2010.11.011)

Colloby, S.J., Firbank, M.J., Pakrasi, S., Perry, E.K., Pimlott, S.L. , Wyper, D.J., McKeith, I.G., Williams, E.D. and O’Brien, J.T. (2011) Alterations in nicotinic α4β2 receptor binding in vascular dementia using 123I-5IA-85380 SPECT: Comparison with regional cerebral blood flow. Neurobiology of Aging, 32(2), pp. 293-301. (doi: 10.1016/j.neurobiolaging.2009.02.005)

Pimlott, S.L. and Sutherland, A. (2011) Molecular tracers for the PET and SPECT imaging of disease. Chemical Society Reviews, 40(1), pp. 149-162. (doi: 10.1039/B922628C)

Tavares, A.A.S., Jobson, N.K., Dewar, D. , Sutherland, A. and Pimlott, S.L. (2011) ¹²³I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65(7), pp. 658-667. (doi: 10.1002/syn.20895)

2010

Cavanagh, J. , Patterson, J., Pimlott, S. , Wyper, D. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: In vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi: 10.1002/syn.20705) (PMID:19771591)

Colloby, S.J., Perry, E.K., Pakrasi, S., Pimlott, S.L., Wyper, D.J., McKeith, I.G., Williams, E.D. and O'Brien, J.T. (2010) Nicotinic I-123-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in alzheimer's disease and dementia with Lewy bodies. American Journal of Geriatric Psychiatry, 18(1), pp. 86-90. (doi: 10.1097/JGP.0b013e3181b972aa)

Cavanagh, J. , Paterson, C., McLean, J., Pimlott, S. , McDonald, M., Patterson, J., Wyper, D. and McInnes, I. (2010) Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study. Annals of the Rheumatic Diseases, 69(6), 1251-U367. (doi: 10.1136/ard.2009.107912)

Lewis, D.Y., Champion, S. , Dewar, D. , Honey, G., Gross, J., Robichaud, A.J., Welch, A., Wyper, D. and Pimlott, S. (2010) Characterisation of novel histamine H3 receptor tracers for SPECT. Molecular Imaging and Biology, 12(S122), pp. 462-493.

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D. , Pimlott, S.L. and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20(3), pp. 954-957. (doi: 10.1016/j.bmcl.2009.12.061)

Terri, E., Dempsey, M.F., Herrmann, L.L., Tierney, K.M., Lonie, J.A., O 19Carroll, R. E., Pimlott, S. , Wyper, D. J., Herholz, K. and Ebmeier, K.P. (2010) 5-¹²³I-A-85380 binding to the α4Β2-nicotinic receptor in mild cognitive impairment. Neurobiology of Aging, 31(11), pp. 1885-1893. (doi: 10.1016/j.neurobiolaging.2008.10.008)

2009

Cain, S.M., Ruest, T., Pimlott, S.L., Patterson, J., Duncan, R.D., Dewar, D. and Sills, G.J. (2009) High resolution micro-SPECT scanning in rats using I-125 beta-CIT: Effects of chronic treatment with carbamazepine. Epilepsia, 50(8), pp. 1962-1970. (doi: 10.1111/j.1528-1167.2009.02095.x)

Champion, S. , Lewis, D., Dewar, D. , Honey, G., Gross, J., Robichaud, A., Welch, A., Wyper, D. and Pimlott, S. (2009) Radiosynthesis and evaluation of novel histamine H3 tracers. Eighteenth International Symposium on Radiopharmaceutical Sciences, Edmonton, Canada, 12 – 17 Jul 2009. S381. (doi: 10.1002/jlcr.1646)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19(17), pp. 4996-4998. (doi: 10.1016/j.bmcl.2009.07.064)

Knol, R.J.J., De Bruin, K., Van Eck-Smit, B.L.F., Pimlott, S.L. , Wyper, D.J. and Booij, J. (2009) In vivo [123I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats. Synapse, 63(7), pp. 557-564. (doi: 10.1002/syn.20629)

Lewis, D., Champion, S. , Dewar, D. , Honey, G., Gross, J., Robichaud, A., Welch, A., Wyper, D. and Pimlott, S. (2009) Characterisation of Novel Histamine H3 receptor tracers for SPECT. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S381. (doi: 10.1002/jlcr.1646)

2008

O’Brien, J. T., Colloby, S. J., Pakrasi, S., Perry, E. K., Pimlott, S. L. , Wyper, D. J., McKeith, I. G. and Williams, E. D. (2008) Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations. NeuroImage, 40(3), pp. 1056-1063. (doi: 10.1016/j.neuroimage.2008.01.010) (PMID:18295510))

Colloby, S.J., Pakrasi, S., Perry, E.K., Pimlott, S.L. , Wyper, D.J., Williams, E.D., McKeith, I.G. and O'Brien, J.T. (2008) The effects of donepezil on nicotinic receptor status in dementia: a ¹²³I-5IA-85380 SPECT study. Journal of Neurology, Neurosurgery and Psychiatry, 79(4), pp. 485-487. (doi: 10.1136/jnnp.2007.121780)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi: 10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6(13), pp. 2369-2376. (doi: 10.1039/b802819b)

McCluskey, A., Boyd, M., Pimlott, S., Babich, J., Gaze, M. and Mairs, R. (2008) Experimental treatment of neuroblastoma using [I-131]meta-iodobenzylguanidine and topotecan in combination. British Journal of Radiology, 81(Sp. Is), S28-S35. (doi: 10.1259/bjr/27723093)

Pimlott, S. L. , Stevenson, L., Wyper, D. J. and Sutherland, A. (2008) Rapid and efficient radiosynthesis of [I-123]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors. Nuclear Medicine and Biology, 35(5), pp. 537-542. (doi: 10.1016/j.nucmedbio.2008.02.013)

Terrière, E. et al. (2008) α4β2-nicotinic receptor binding with 5-IA in Alzheimer’s disease: methods of scan analysis. Neurochemical Research, 33(4), pp. 643-651. (doi: 10.1007/s11064-007-9517-4)

2007

Pimlott, S.L. and Ebmeier, K.P. (2007) SPECT imaging in dementia. British Journal of Radiology, 80(S2), S153-S159. (doi: 10.1259/bjr/89285735) (PMID:18445745)

O'Brien, J.T., Colloby, S.J., Pakrasi, S., Perry, E.K., Pimlott, S.L. , Wyper, D.J., McKeith, I.G. and Williams, E. (2007) Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography. Journal of Neurology Neurosurgery and Psychiatry, 78(4), pp. 356-362. (doi: 10.1136/jnnp.2006.108209) (PMID:17135460) (PMCID:PMC2077777)

Stevenson, L., Pimlott, S. L. and Sutherland, A. (2007) A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195. Tetrahedron Letters, 48(40), pp. 7137-7139. (doi: 10.1016/j.tetlet.2007.07.203)

Pimlott, S. L. , Piggott, M., Patterson, J., Cavanagh, J. and Wyper, D. J. (2007) SPECT imaging of the α4β2 nicotinic receptor using [5-¹²³I]A85380. Journal of Labelled Compounds and Radiopharmaceuticals, 50(5-6), pp. 350-353. (doi: 10.1002/jlcr.1192)

2006

Perry, E.K. et al. (2006) Cholinergic pathology in Lewy body dementia. International Symposium on Dementia in Parkinson's Disease 2004, Salzburg, Austria, 24-27, Oct 2004. pp. 312-313.

Dempsey, M. F., Wyper, D., Owens, J., Pimlott, S. , Papanastassiou, V., Patterson, J., Hadley, D. M., Nicol, A., Rampling, R. and Brown, S.M. (2006) Assessment of I-123-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma. Nuclear Medicine Communications, 27(8), pp. 611-617. (doi: 10.1097/00006231-200608000-00003) (PMID:16829761)

O'Brien, J. T., Colloby, S. J., Pakrasi, S., Perry, E. K., Pimlott, S. L. and Wyper, D. J. (2006) Measurement of the α4β2 nicotinic receptor in vivo in Alzheimer's disease with 123I–5IA–85380 SPECT. Alzheimer's Association 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, 15-20 Jul 2006. S677. (doi: 10.1016/j.jalz.2006.05.2264)

Pimlott, S.L. , Piggott, M., Ballard, C., McKeith, I., Perry, R., Kometa, S., Owens, J., Wyper, D. and Perry, E. (2006) Thalamic nicotinic receptors implicated in disturbed consciousness in dementia with Lewy bodies. Neurobiology of Disease, 21(1), pp. 50-56. (doi: 10.1016/j.nbd.2005.06.008) (PMID:16023355)

2005

Pimlott, S. L. (2005) Radiotracer development in psychiatry. Nuclear Medicine Communications, 26(3), pp. 183-188. (doi: 10.1097/00006231-200503000-00002) (PMID:15722898)

Norbury, R., Travis, M.J., Erlandsson, K., Waddington, W., Owens, J., Pimlott, S. , Ell, P.J. and Murphy, D.G.M. (2005) In vivo imaging of muscarinic receptors in the aging female brain with (R,R)[123I]-I-QNB and single photon emission tomography. Experimental Gerontology, 40(3), pp. 137-145. (doi: 10.1016/j.exger.2004.10.002) (PMID:15763390)

2004

Pimlott, S.L. , Piggott, M., Owens, J., Greally, E., Court, J.A., Jaros, E., Perry, R.H., Perry, E.K. and Wyper, D. (2004) Nicotinic Acetylcholine Receptor Distribution in Alzheimer's Disease, Dementia with Lewy Bodies, Parkinson's Disease, and Vascular Dementia: In Vitro Binding Study Using 5-[125I]-A-85380. Neuropsychopharmacology, 29, pp. 108-116. (doi: 10.1038/sj.npp.1300302) (PMID:12955099)

2003

Pimlott, S.L. , Owens, J. and Wyper, D. (2003) Novel SPECT receptor ligands for the investigation of dementia. In: Ebmeier, K.P. (ed.) SPECT in Dementia. Series: Advances in Biological Psychiatry, 22. S. Karger AG, pp. 95-114.

Brown, D., Chisholm, J. A., Owens, J., Pimlott, S. , Patterson, J. and Wyper, D. (2003) Acetylcholine muscarinic receptors and response to anti-cholinesterase therapy in patients with Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 30(2), pp. 296-300. (doi: 10.1007/s00259-002-1028-6) (PMID:12552349)

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