Professor Martin Brodie
- Honorary Professor (School of Medicine, Dentistry & Nursing)
Publications
2023
Hakeem, H., Alsfouk, B. A. A., Kwan, P., Brodie, M. J. and Chen, Z. (2023) Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30-year cohort study. Epilepsia, 64(5), pp. 1248-1258. (doi: 10.1111/epi.17573) (PMID:36869855)
2022
Stevelink, R. et al. (2022) Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis. EClinicalMedicine, 53, 101732. (doi: 10.1016/j.eclinm.2022.101732) (PMID:36467455) (PMCID:PMC9716332)
Hakeem, H. et al. (2022) Development and validation of a deep learning model for predicting treatment response in patients with newly diagnosed epilepsy. JAMA Neurology, 79(10), pp. 986-996. (doi: 10.1001/jamaneurol.2022.2514) (PMID:36036923) (PMCID:PMC9425285)
Mesraoua, B., Tomson, T., Brodie, M. and Asadi-Pooya, A. A. (2022) Sudden unexpected death in epilepsy (SUDEP): Definition, epidemiology, and significance of education. Epilepsy and Behavior, 132, 108742. (doi: 10.1016/j.yebeh.2022.108742) (PMID:35623204)
Brodie, M. J. (2022) Prescription patterns among people with epilepsy. Epilepsy and Behavior, 130, 108690. (doi: 10.1016/j.yebeh.2022.108690) (PMID:35427939)
Mula, M., Brodie, M. J., de Toffol, B., Guekht, A., Hecimovic, H., Kanemoto, K., Kanner, A. M., Teixeira, A. L. and Wilson, S. J. (2022) ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy. Epilepsia, 63(2), pp. 316-334. (doi: 10.1111/epi.17140) (PMID:34866176)
Walker, L. E., Sills, G. J., Jorgensen, A., Alapirtti, T., Peltola, J., Brodie, M. J., Marson, A. G., Vezzani, A. and Pirmohamed, M. (2022) High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: a proof-of-concept study. Epilepsia, 63(1), e1-e6. (doi: 10.1111/epi.17116) (PMID:34747496)
2021
Andraus, M. et al. (2021) Impact of the COVID-19 pandemic on people with epilepsy: findings from the Brazilian arm of the COV-E study. Epilepsy and Behavior, 123, 108261. (doi: 10.1016/j.yebeh.2021.108261) (PMID:34481281)
2020
Alsfouk, B. A. A., Brodie, M. J., Walters, M. , Kwan, P. and Chen, Z. (2020) Tolerability of antiseizure medications in individuals with newly diagnosed epilepsy. JAMA Neurology, 77(5), pp. 574-581. (doi: 10.1001/jamaneurol.2020.0032) (PMID:32091535)
2018
Brodie, M. J., Fakhoury, T., McDonough, B., Colson, A.-O., Stockis, A., Elmoufti, S. and Whitesides, J. (2018) Brivaracetam-induced elevation of carbamazepine epoxide levels: a post-hoc analysis from the clinical development program. Epilepsy Research, 145, pp. 55-62. (doi: 10.1016/j.eplepsyres.2018.06.002) (PMID:29908435)
2016
Brodie, M. J., Whitesides, J., Schiemann, J., D'Souza, J. and Johnson, M. E. (2016) Tolerability, safety, and efficacy of adjunctive brivaracetam for focal seizures in older patients: A pooled analysis from three phase III studies. Epilepsy Research, 127, pp. 114-118. (doi: 10.1016/j.eplepsyres.2016.08.018) (PMID:27589414)
Trinka, E., Steinhoff, B.J., Nikanorova, M. and Brodie, M.J. (2016) Perampanel for focal epilepsy: insights from early clinical experience. Acta Neurologica Scandinavica, 133(3), pp. 160-172. (doi: 10.1111/ane.12529) (PMID:26506904) (PMCID:PMC4738453)
Brodie, M. J. and Stephen, L. J. (2016) Prospective audit with adjunctive perampanel: preliminary observations in focal epilepsy. Epilepsy and Behavior, 54, pp. 100-103. (doi: 10.1016/j.yebeh.2015.11.002) (PMID:26700063)
Chowdhury, A. and Brodie, M. J. (2016) Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate. Epilepsy Research, 119, pp. 62-66. (doi: 10.1016/j.eplepsyres.2015.11.012) (PMID:26675554)
2015
Beacher, N. G., Brodie, M. J. and Goodall, C. (2015) A case report: retigabine induced oral mucosal dyspigmentation of the hard palate. BMC Oral Health, 15(1), 122. (doi: 10.1186/s12903-015-0102-y) (PMID:26452759)
Brodie, M. J. (2015) Practical use of newer antiepileptic drugs as adjunctive therapy in focal epilepsy. CNS Drugs, 29(11), pp. 893-904. (doi: 10.1007/s40263-015-0285-4) (PMID:26507832)
Rektor, I. et al. (2015) Third International Congress on Epilepsy, Brain, and Mind: part 2. Epilepsy and Behavior, 50, pp. 138-159. (doi: 10.1016/j.yebeh.2015.07.014) (PMID:26264466)
2014
Shazadi, K. et al. (2014) Validation of a multigenic model to predict seizure control in newly treated epilepsy. Epilepsy Research, 108(10), pp. 1797-1805. (doi: 10.1016/j.eplepsyres.2014.08.022)
Brodie, M. J. (2014) Happy anniversary, Epilepsy & Behavior. Epilepsy and Behavior, 40, p. 79. (doi: 10.1016/j.yebeh.2014.09.001)
Stephen, L. J., Kelly, K., Parker, P. and Brodie, M. J. (2014) Adjunctive lacosamide—5 years’ clinical experience. Epilepsy Research, 108(8), pp. 1385-1391. (doi: 10.1016/j.eplepsyres.2014.06.018) (PMID:25064538)
Brodie, M. J., French, J. A., McDonald, S. A., Lee, W.-J., Adams, B., Scott, A., Nohria, V. and DeRossett, S. (2014) Adjunctive use of ezogabine/retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: evaluation of efficacy and tolerability. Epilepsy Research, 108(5), pp. 989-994. (doi: 10.1016/j.eplepsyres.2014.03.008)
Brodie, M.J., Kelly, K. and Stephen, L.J. (2014) Prospective audits with newer antiepileptic drugs in focal epilepsy: Insights into population responses? Epilepsy and Behavior, 31, pp. 73-76. (doi: 10.1016/j.yebeh.2013.11.016)
2013
Biton, V., Gil-Nagel, A., Brodie, M.J., DeRossett, S.E. and Nohria, V. (2013) Safety and tolerability of different titration rates of retigabine (ezogabine) in patients with partial-onset seizures. Epilepsy Research, 107(1-2), pp. 138-145. (doi: 10.1016/j.eplepsyres.2013.08.021)
Hao, X., Goldberg, D., Kelly, K., Stephen, L., Kwan, P. and Brodie, M.J. (2013) Uncontrolled epilepsy is not necessarily the same as drug-resistant epilepsy: Differences between populations with newly diagnosed epilepsy and chronic epilepsy. Epilepsy and Behavior, 29(1), pp. 4-6. (doi: 10.1016/j.yebeh.2013.06.019)
Korczyn, A.D. et al. (2013) Epilepsy, cognition, and neuropsychiatry (epilepsy, brain, and mind, part 2). Epilepsy and Behavior, 28(2), pp. 283-302. (doi: 10.1016/j.yebeh.2013.03.012)
Brenner, T., Sills, G.J., Hart, Y., Howell, S., Waters, P., Brodie, M.J., Vincent, A. and Lang, B. (2013) Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy. Epilepsia, 54(6), pp. 1028-1035. (doi: 10.1111/epi.12127)
Mohanraj, R. and Brodie, M.J. (2013) Early predictors of outcome in newly diagnosed epilepsy. Seizure, 22(5), pp. 333-344. (doi: 10.1016/j.seizure.2013.02.002)
Brodie, M.J. (2013) Road to refractory epilepsy: the Glasgow story. Epilepsia, 54(S2), pp. 5-8. (doi: 10.1111/epi.12175)
Brodie, M., Barry, S. , Bamagous, G. and Kwan, P. (2013) Effect of dosage failed of first antiepileptic drug on subsequent outcome. Epilepsia, 54(1), pp. 194-198. (doi: 10.1111/j.1528-1167.2012.03722.x)
2012
Brodie, M.J., Ben-Menachem, E., Chouette, I. and Giorgi, L. (2012) Zonisamide: its pharmacology, efficacy and safety in clinical trials. Acta Neurologica Scandinavica, 126(s194), pp. 19-28. (doi: 10.1111/ane.12016)
Brodie, M.J. and Kwan, P. (2012) Current position of phenobarbital in epilepsy and its future. Epilepsia, 53(s8), pp. 40-46. (doi: 10.1111/epi.12027)
Gil-Nagel, A., Brodie, M.J., Leroy, R., Cyr, T., Hall, S., Castiglia, M., Twomey, C. and VanLandingham, K. (2012) Safety and efficacy of ezogabine (retigabine) in adults with refractory partial-onset seizures: interim results from two ongoing open-label studies. Epilepsy Research, 102(1-2), pp. 117-121. (doi: 10.1016/j.eplepsyres.2012.05.007)
Baulac, M., Brodie, M.J., Patten, A., Segieth, J. and Giorgi, L. (2012) Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurology, 11(7), pp. 579-588. (doi: 10.1016/S1474-4422(12)70105-9)
Brodie, M.J. (2012) Novel trial designs for monotherapy. Epileptic Disorders, 14(2), pp. 132-137. (doi: 10.1684/epd.2012.0513)
Brodie, M.J., Barry, S.J.E. , Bamagous, G.A., Norrie, J.D. and Kwan, P. (2012) Patterns of treatment response in newly diagnosed epilepsy. Neurology, 78(20), 1548 -1554. (doi: 10.1212/WNL.0b013e3182563b19)
Brodie, M. and Kwan, P. (2012) Newer drugs for focal epilepsy in adults. British Medical Journal, 344, e345. (doi: 10.1136/bmj.e345)
Brodie, M. J., Mintzer, S., Pack, A. M., Gidal, B. E., Vecht, C. J. and Schmidt, D. (2012) Enzyme induction with antiepileptic drugs: Cause for concern? Epilepsia, 54(1), pp. 11-27. (doi: 10.1111/j.1528-1167.2012.03671.x)
2011
Kwan, P., Brodie, M.J., Kälviäinen, R., Yurkewicz, L., Weaver, J. and Knapp, L.E. (2011) Efficacy and safety of pregabalin versus lamotrigine in patients with newly diagnosed partial seizures: a phase 3, double-blind, randomised, parallel-group trial. Lancet Neurology, 10(10), pp. 881-890. (doi: 10.1016/S1474-4422(11)70154-5)
Hesdorffer, D. C., Tomson, T., Benn, E., Sander, J. W., Nilsson, L., Langan, Y., Walczak, T. S., Beghi, E., Brodie, M. J. and Hauser, A. (2011) Combined analysis of risk factors for SUDEP. Epilepsia, 52(6), pp. 1150-1159. (doi: 10.1111/j.1528-1167.2010.02952.x)
Hesdorffer, D. C., Tomson, T., Benn, E., Sander, J. W., Nilsson, L., Langan, Y., Walczak, T. S., Beghi, E., Brodie, M. J. and Hauser, W. A. (2011) Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis. Epilepsia, 53(2), pp. 249-252. (doi: 10.1111/j.1528-1167.2011.03354.x)
2010
Kwan, P., Arzimanoglou, A., Berg, A., Brodie, M.J.,, Hauser, W.A., Mathern, G., Moshe, S.L., Perucca, E., Wiebe, S. and French, J., (2010) Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51(6), pp. 1069-1077. (doi: 10.1111/j.1528-1167.2009.02397.x)
2009
Makmor-Bakry, M., Sills, G.J., Hitiris, N., Butler, E., Wilson, E.A. and Brodie, M.J. (2009) Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing. Clinical Neuropharmacology, 32(4), pp. 205-212.
Szoeke, C. et al. (2009) Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts. Epilepsia, 50(7), pp. 1689-1696. (doi: 10.1111/j.1528-1167.2009.02059.x) (PMID:19453704)
2007
Stephen, L. J., Sills, G. J., Leach, J. P., Butler, E., Parker, P., Hitiris, N., Leach, V. M., Wilson, E. A. and Brodie, M. J. (2007) Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. Epilepsy Research, 75(2-3), pp. 122-129. (doi: 10.1016/j.eplepsyres.2007.04.009) (PMID:17553671)
Hitiris, N., Mohanraj, R., Norrie, J., Sills, G. J. and Brodie, M. J. (2007) Predictors of pharmacoresistant epilepsy. Epilepsy Research, 75(2-3), pp. 192-196. (doi: 10.1016/j.eplepsyres.2007.06.003) (PMID:17628429)
Hitiris, N., Suratman, S., Kelly, K., Stephen, L. J., Sills, G. J. and Brodie, M. J. (2007) Sudden unexpected death in epilepsy: a search for risk factors. Epilepsy and Behavior, 10(1), pp. 138-141. (doi: 10.1016/j.yebeh.2006.11.010) (PMID:17196884)
Sills, G. J. and Brodie, M. J. (2007) Pharmacokinetics and drug interactions with xonisamide. Epilepsia, 48(3), pp. 435-441. (doi: 10.1111/j.1528-1167.2007.00983.x) (PMID:17319920)
2006
Sills, G. J. and Brodie, M. J. (2006) Response: Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia, 47(2), p. 450. (doi: 10.1111/j.1528-1167.2006.00444_2.x)
2005
Sills, G. J., Mohanraj, R., Butler, E., McCrindle, S., Collier, L., Wilson, E. A. and Brodie, M. J. (2005) Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia, 46(5), pp. 643-647. (doi: 10.1111/j.1528-1167.2005.46304.x) (PMID:15857428)
2004
Sills, G. J., Butler, E., Thompson, G. G. and Brodie, M. J. (2004) Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. Seizure, 13(5), pp. 287-295. (doi: 10.1016/S1059-1311(03)00185-7) (PMID:15158698)
2003
McDonagh, J., Stephen, L.J., Dolan, F.M., Parks, S., Dutton, G.N., Kelly, K., Keating, D., Sills, G.J. and Brodie, M.J. (2003) Peripheral retinal dysfunction in patients taking vigabatrin. Neurology, 61(12), pp. 1690-1694. (doi: 10.1212/01.WNL.0000098938.80082.25) (PMID:14694031)
Sills, G. J., Butler, E., Forrest, G., Ratnaraj, N., Patsalos, P. N. and Brodie, M. J. (2003) Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in Rat brain and retina. Epilepsia, 44(7), pp. 886-892. (doi: 10.1046/j.1528-1157.2003.04203.x) (PMID:12823570)
2002
Kelly, K., Stephen, L. J., Sills, G. J. and Brodie, M. J. (2002) Topiramate in patients with learning disability and refractory epilepsy. Epilepsia, 43(4), pp. 399-402. (doi: 10.1046/j.1528-1157.2002.47401.x) (PMID:11952770)
Kwan, P., Sills, G. J., Butler, E., Gant, T. W., Meldrum, B. S. and Brodie, M. J. (2002) Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure. Epilepsia, 43(11), pp. 1318-1323. (doi: 10.1046/j.1528-1157.2002.156702.x) (PMID:12423380)
Santangeli, S., Sills, G. J., Thompson, G. G. and Brodie, M. J. (2002) Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. European Journal of Pharmacology, 438(1-2), pp. 63-68. (doi: 10.1016/S0014-2999(02)01297-9) (PMID:11906711)
Sills, G. J., Kwan, P., Butler, E., de Lange, E. C.M., van den Berg, D.-J. and Brodie, M. J. (2002) P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice. Epilepsy and Behavior, 3(5), pp. 427-432. (doi: 10.1016/S1525-5050(02)00511-5) (PMID:12609264)
Sills, G. J., Santangeli, S., Forrest, G. and Brodie, M. J. (2002) Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. Epilepsy Research, 49(3), pp. 247-254. (doi: 10.1016/S0920-1211(02)00049-9) (PMID:12076846)
2001
Sills, G.J. and Brodie, M.J. (2001) Update on the mechanisms of action of antiepileptic drugs. Epileptic Disorders, 3(4), pp. 165-172. (PMID:11844711)
Kwan, P., Sills, G. J. and Brodie, M. J. (2001) The mechanisms of action of commonly used antiepileptic drugs. Pharmacology and Therapeutics, 90(1), pp. 21-34. (doi: 10.1016/S0163-7258(01)00122-X) (PMID:11448723)
Sills, G.J., Patsalos, P.N., Butler, E., Forrest, G., Ratnaraj, N. and Brodie, M.J. (2001) Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina. Neurology, 57(2), pp. 196-200. (doi: 10.1212/WNL.57.2.196) (PMID:11468302)
2000
Sills, G. J., Leach, J. P. P., Kilpatrick, W. S., Fraser, C. M., Thompson, G. G. and Brodie, M. J. (2000) Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt. Epilepsia, 41(s1), pp. 30-34. (doi: 10.1111/j.1528-1157.2000.tb02168.x) (PMID:10768297)
Kwan, P., Sills, G. J., Kelly, K., Butler, E. and Brodie, M. J. (2000) Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Research, 42(2-3), pp. 191-195. (doi: 10.1016/S0920-1211(00)00180-7) (PMID:11074191)
Santangeli, S., McNeill, C., Sills, G. J. and Brodie, M. J. (2000) Simultaneous determination of remacemide hydrochloride and desglycinylremacemide (AR-R12495XX) in brain tissue by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 746(2), pp. 325-329. (doi: 10.1016/S0378-4347(00)00329-7) (PMID:11076087)
1999
Fraser, C. M., Sills, G. J., Forrest, G., Thompson, G. G. and Brodie, M. J. (1999) Neurochemical studies with the anticonvulsant felbamate in mouse brain. Pharmacological Research, 40(3), pp. 257-261. (doi: 10.1006/phrs.1999.0511) (PMID:10479470)
Sills, G. J., Butler, E., Thompson, G. G. and Brodie, M. J. (1999) Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study. Seizure, 8(7), pp. 404-411. (doi: 10.1053/seiz.1999.0326) (PMID:10600581)
1998
Stephen, L. J., Sills, G. J. and Brodie, M. J. (1998) Lamotrigine and topiramate may be a useful combination. Lancet, 351(9107), pp. 958-959. (doi: 10.1016/S0140-6736(05)60613-7) (PMID:9734949)
Wilson, E. A., Sills, G. J., Forrest, G. and Brodie, M. J. (1998) High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients. Epilepsy Research, 29(2), pp. 161-166. (doi: 10.1016/S0920-1211(97)00078-8) (PMID:9477149)
1997
Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of gabapentin in mouse brain. Epilepsy Research, 27(3), pp. 175-180. (doi: 10.1016/S0920-1211(97)01034-6) (PMID:9237051)
Sills, G. J., Leach, J. P., Fraser, C. M., Forrest, G., Patsalos, P. N. and Brodie, M. J. (1997) Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. European Journal of Pharmacology, 325(1), pp. 35-40. (doi: 10.1016/S0014-2999(97)00105-2) (PMID:9151936)
Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain. British Journal of Pharmacology, 121(5), pp. 923-926. (doi: 10.1038/sj.bjp.0701219) (PMID:9222548) (PMCID:PMC1564774)
1996
Leach, J. P., Sills, G. J., Majid, A., Butler, E., Carswell, A., Thompson, G. G. and Brodie, M. J. (1996) Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure, 5(3), pp. 229-234. (doi: 10.1016/S1059-1311(96)80041-0) (PMID:8902926)
Forrest, G., Sills, G. J., Leach, J. P. and Brodie, M. J. (1996) Determination of gabapentin in plasma by high-performance liquid chromatography. Journal of Chromatography B, 681(2), pp. 421-425. (doi: 10.1016/0378-4347(96)00074-6) (PMID:8811458)
1995
Hannah, J. A., Sills, G. J. and Brodie, M. J. (1995) Established and new antiepileptic drugs: an overview. In: Aldenkamp, A. P., Dreifuss, F. E., Reiner, W. O. and Suurmeijer, T. P.B.M. (eds.) Epilepsy in Children and Adolescents. CRC Press: Boca Raton, pp. 101-129. ISBN 0849376599
1992
Connick, J.H., Heywood, G.C., Sills, G.J., Thompson, G.G., Brodie, M.J. and Stone, T.W. (1992) Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity. General Pharmacology: The Vascular System, 23(2), pp. 235-239. (doi: 10.1016/0306-3623(92)90017-E) (PMID:1639238)
Articles
Hakeem, H., Alsfouk, B. A. A., Kwan, P., Brodie, M. J. and Chen, Z. (2023) Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30-year cohort study. Epilepsia, 64(5), pp. 1248-1258. (doi: 10.1111/epi.17573) (PMID:36869855)
Stevelink, R. et al. (2022) Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis. EClinicalMedicine, 53, 101732. (doi: 10.1016/j.eclinm.2022.101732) (PMID:36467455) (PMCID:PMC9716332)
Hakeem, H. et al. (2022) Development and validation of a deep learning model for predicting treatment response in patients with newly diagnosed epilepsy. JAMA Neurology, 79(10), pp. 986-996. (doi: 10.1001/jamaneurol.2022.2514) (PMID:36036923) (PMCID:PMC9425285)
Mesraoua, B., Tomson, T., Brodie, M. and Asadi-Pooya, A. A. (2022) Sudden unexpected death in epilepsy (SUDEP): Definition, epidemiology, and significance of education. Epilepsy and Behavior, 132, 108742. (doi: 10.1016/j.yebeh.2022.108742) (PMID:35623204)
Brodie, M. J. (2022) Prescription patterns among people with epilepsy. Epilepsy and Behavior, 130, 108690. (doi: 10.1016/j.yebeh.2022.108690) (PMID:35427939)
Mula, M., Brodie, M. J., de Toffol, B., Guekht, A., Hecimovic, H., Kanemoto, K., Kanner, A. M., Teixeira, A. L. and Wilson, S. J. (2022) ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy. Epilepsia, 63(2), pp. 316-334. (doi: 10.1111/epi.17140) (PMID:34866176)
Walker, L. E., Sills, G. J., Jorgensen, A., Alapirtti, T., Peltola, J., Brodie, M. J., Marson, A. G., Vezzani, A. and Pirmohamed, M. (2022) High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: a proof-of-concept study. Epilepsia, 63(1), e1-e6. (doi: 10.1111/epi.17116) (PMID:34747496)
Andraus, M. et al. (2021) Impact of the COVID-19 pandemic on people with epilepsy: findings from the Brazilian arm of the COV-E study. Epilepsy and Behavior, 123, 108261. (doi: 10.1016/j.yebeh.2021.108261) (PMID:34481281)
Alsfouk, B. A. A., Brodie, M. J., Walters, M. , Kwan, P. and Chen, Z. (2020) Tolerability of antiseizure medications in individuals with newly diagnosed epilepsy. JAMA Neurology, 77(5), pp. 574-581. (doi: 10.1001/jamaneurol.2020.0032) (PMID:32091535)
Brodie, M. J., Fakhoury, T., McDonough, B., Colson, A.-O., Stockis, A., Elmoufti, S. and Whitesides, J. (2018) Brivaracetam-induced elevation of carbamazepine epoxide levels: a post-hoc analysis from the clinical development program. Epilepsy Research, 145, pp. 55-62. (doi: 10.1016/j.eplepsyres.2018.06.002) (PMID:29908435)
Brodie, M. J., Whitesides, J., Schiemann, J., D'Souza, J. and Johnson, M. E. (2016) Tolerability, safety, and efficacy of adjunctive brivaracetam for focal seizures in older patients: A pooled analysis from three phase III studies. Epilepsy Research, 127, pp. 114-118. (doi: 10.1016/j.eplepsyres.2016.08.018) (PMID:27589414)
Trinka, E., Steinhoff, B.J., Nikanorova, M. and Brodie, M.J. (2016) Perampanel for focal epilepsy: insights from early clinical experience. Acta Neurologica Scandinavica, 133(3), pp. 160-172. (doi: 10.1111/ane.12529) (PMID:26506904) (PMCID:PMC4738453)
Brodie, M. J. and Stephen, L. J. (2016) Prospective audit with adjunctive perampanel: preliminary observations in focal epilepsy. Epilepsy and Behavior, 54, pp. 100-103. (doi: 10.1016/j.yebeh.2015.11.002) (PMID:26700063)
Chowdhury, A. and Brodie, M. J. (2016) Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate. Epilepsy Research, 119, pp. 62-66. (doi: 10.1016/j.eplepsyres.2015.11.012) (PMID:26675554)
Beacher, N. G., Brodie, M. J. and Goodall, C. (2015) A case report: retigabine induced oral mucosal dyspigmentation of the hard palate. BMC Oral Health, 15(1), 122. (doi: 10.1186/s12903-015-0102-y) (PMID:26452759)
Brodie, M. J. (2015) Practical use of newer antiepileptic drugs as adjunctive therapy in focal epilepsy. CNS Drugs, 29(11), pp. 893-904. (doi: 10.1007/s40263-015-0285-4) (PMID:26507832)
Rektor, I. et al. (2015) Third International Congress on Epilepsy, Brain, and Mind: part 2. Epilepsy and Behavior, 50, pp. 138-159. (doi: 10.1016/j.yebeh.2015.07.014) (PMID:26264466)
Shazadi, K. et al. (2014) Validation of a multigenic model to predict seizure control in newly treated epilepsy. Epilepsy Research, 108(10), pp. 1797-1805. (doi: 10.1016/j.eplepsyres.2014.08.022)
Brodie, M. J. (2014) Happy anniversary, Epilepsy & Behavior. Epilepsy and Behavior, 40, p. 79. (doi: 10.1016/j.yebeh.2014.09.001)
Stephen, L. J., Kelly, K., Parker, P. and Brodie, M. J. (2014) Adjunctive lacosamide—5 years’ clinical experience. Epilepsy Research, 108(8), pp. 1385-1391. (doi: 10.1016/j.eplepsyres.2014.06.018) (PMID:25064538)
Brodie, M. J., French, J. A., McDonald, S. A., Lee, W.-J., Adams, B., Scott, A., Nohria, V. and DeRossett, S. (2014) Adjunctive use of ezogabine/retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: evaluation of efficacy and tolerability. Epilepsy Research, 108(5), pp. 989-994. (doi: 10.1016/j.eplepsyres.2014.03.008)
Brodie, M.J., Kelly, K. and Stephen, L.J. (2014) Prospective audits with newer antiepileptic drugs in focal epilepsy: Insights into population responses? Epilepsy and Behavior, 31, pp. 73-76. (doi: 10.1016/j.yebeh.2013.11.016)
Biton, V., Gil-Nagel, A., Brodie, M.J., DeRossett, S.E. and Nohria, V. (2013) Safety and tolerability of different titration rates of retigabine (ezogabine) in patients with partial-onset seizures. Epilepsy Research, 107(1-2), pp. 138-145. (doi: 10.1016/j.eplepsyres.2013.08.021)
Hao, X., Goldberg, D., Kelly, K., Stephen, L., Kwan, P. and Brodie, M.J. (2013) Uncontrolled epilepsy is not necessarily the same as drug-resistant epilepsy: Differences between populations with newly diagnosed epilepsy and chronic epilepsy. Epilepsy and Behavior, 29(1), pp. 4-6. (doi: 10.1016/j.yebeh.2013.06.019)
Korczyn, A.D. et al. (2013) Epilepsy, cognition, and neuropsychiatry (epilepsy, brain, and mind, part 2). Epilepsy and Behavior, 28(2), pp. 283-302. (doi: 10.1016/j.yebeh.2013.03.012)
Brenner, T., Sills, G.J., Hart, Y., Howell, S., Waters, P., Brodie, M.J., Vincent, A. and Lang, B. (2013) Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy. Epilepsia, 54(6), pp. 1028-1035. (doi: 10.1111/epi.12127)
Mohanraj, R. and Brodie, M.J. (2013) Early predictors of outcome in newly diagnosed epilepsy. Seizure, 22(5), pp. 333-344. (doi: 10.1016/j.seizure.2013.02.002)
Brodie, M.J. (2013) Road to refractory epilepsy: the Glasgow story. Epilepsia, 54(S2), pp. 5-8. (doi: 10.1111/epi.12175)
Brodie, M., Barry, S. , Bamagous, G. and Kwan, P. (2013) Effect of dosage failed of first antiepileptic drug on subsequent outcome. Epilepsia, 54(1), pp. 194-198. (doi: 10.1111/j.1528-1167.2012.03722.x)
Brodie, M.J., Ben-Menachem, E., Chouette, I. and Giorgi, L. (2012) Zonisamide: its pharmacology, efficacy and safety in clinical trials. Acta Neurologica Scandinavica, 126(s194), pp. 19-28. (doi: 10.1111/ane.12016)
Brodie, M.J. and Kwan, P. (2012) Current position of phenobarbital in epilepsy and its future. Epilepsia, 53(s8), pp. 40-46. (doi: 10.1111/epi.12027)
Gil-Nagel, A., Brodie, M.J., Leroy, R., Cyr, T., Hall, S., Castiglia, M., Twomey, C. and VanLandingham, K. (2012) Safety and efficacy of ezogabine (retigabine) in adults with refractory partial-onset seizures: interim results from two ongoing open-label studies. Epilepsy Research, 102(1-2), pp. 117-121. (doi: 10.1016/j.eplepsyres.2012.05.007)
Baulac, M., Brodie, M.J., Patten, A., Segieth, J. and Giorgi, L. (2012) Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurology, 11(7), pp. 579-588. (doi: 10.1016/S1474-4422(12)70105-9)
Brodie, M.J. (2012) Novel trial designs for monotherapy. Epileptic Disorders, 14(2), pp. 132-137. (doi: 10.1684/epd.2012.0513)
Brodie, M.J., Barry, S.J.E. , Bamagous, G.A., Norrie, J.D. and Kwan, P. (2012) Patterns of treatment response in newly diagnosed epilepsy. Neurology, 78(20), 1548 -1554. (doi: 10.1212/WNL.0b013e3182563b19)
Brodie, M. and Kwan, P. (2012) Newer drugs for focal epilepsy in adults. British Medical Journal, 344, e345. (doi: 10.1136/bmj.e345)
Brodie, M. J., Mintzer, S., Pack, A. M., Gidal, B. E., Vecht, C. J. and Schmidt, D. (2012) Enzyme induction with antiepileptic drugs: Cause for concern? Epilepsia, 54(1), pp. 11-27. (doi: 10.1111/j.1528-1167.2012.03671.x)
Kwan, P., Brodie, M.J., Kälviäinen, R., Yurkewicz, L., Weaver, J. and Knapp, L.E. (2011) Efficacy and safety of pregabalin versus lamotrigine in patients with newly diagnosed partial seizures: a phase 3, double-blind, randomised, parallel-group trial. Lancet Neurology, 10(10), pp. 881-890. (doi: 10.1016/S1474-4422(11)70154-5)
Hesdorffer, D. C., Tomson, T., Benn, E., Sander, J. W., Nilsson, L., Langan, Y., Walczak, T. S., Beghi, E., Brodie, M. J. and Hauser, A. (2011) Combined analysis of risk factors for SUDEP. Epilepsia, 52(6), pp. 1150-1159. (doi: 10.1111/j.1528-1167.2010.02952.x)
Hesdorffer, D. C., Tomson, T., Benn, E., Sander, J. W., Nilsson, L., Langan, Y., Walczak, T. S., Beghi, E., Brodie, M. J. and Hauser, W. A. (2011) Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis. Epilepsia, 53(2), pp. 249-252. (doi: 10.1111/j.1528-1167.2011.03354.x)
Kwan, P., Arzimanoglou, A., Berg, A., Brodie, M.J.,, Hauser, W.A., Mathern, G., Moshe, S.L., Perucca, E., Wiebe, S. and French, J., (2010) Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51(6), pp. 1069-1077. (doi: 10.1111/j.1528-1167.2009.02397.x)
Makmor-Bakry, M., Sills, G.J., Hitiris, N., Butler, E., Wilson, E.A. and Brodie, M.J. (2009) Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing. Clinical Neuropharmacology, 32(4), pp. 205-212.
Szoeke, C. et al. (2009) Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts. Epilepsia, 50(7), pp. 1689-1696. (doi: 10.1111/j.1528-1167.2009.02059.x) (PMID:19453704)
Stephen, L. J., Sills, G. J., Leach, J. P., Butler, E., Parker, P., Hitiris, N., Leach, V. M., Wilson, E. A. and Brodie, M. J. (2007) Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. Epilepsy Research, 75(2-3), pp. 122-129. (doi: 10.1016/j.eplepsyres.2007.04.009) (PMID:17553671)
Hitiris, N., Mohanraj, R., Norrie, J., Sills, G. J. and Brodie, M. J. (2007) Predictors of pharmacoresistant epilepsy. Epilepsy Research, 75(2-3), pp. 192-196. (doi: 10.1016/j.eplepsyres.2007.06.003) (PMID:17628429)
Hitiris, N., Suratman, S., Kelly, K., Stephen, L. J., Sills, G. J. and Brodie, M. J. (2007) Sudden unexpected death in epilepsy: a search for risk factors. Epilepsy and Behavior, 10(1), pp. 138-141. (doi: 10.1016/j.yebeh.2006.11.010) (PMID:17196884)
Sills, G. J. and Brodie, M. J. (2007) Pharmacokinetics and drug interactions with xonisamide. Epilepsia, 48(3), pp. 435-441. (doi: 10.1111/j.1528-1167.2007.00983.x) (PMID:17319920)
Sills, G. J. and Brodie, M. J. (2006) Response: Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia, 47(2), p. 450. (doi: 10.1111/j.1528-1167.2006.00444_2.x)
Sills, G. J., Mohanraj, R., Butler, E., McCrindle, S., Collier, L., Wilson, E. A. and Brodie, M. J. (2005) Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia, 46(5), pp. 643-647. (doi: 10.1111/j.1528-1167.2005.46304.x) (PMID:15857428)
Sills, G. J., Butler, E., Thompson, G. G. and Brodie, M. J. (2004) Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. Seizure, 13(5), pp. 287-295. (doi: 10.1016/S1059-1311(03)00185-7) (PMID:15158698)
McDonagh, J., Stephen, L.J., Dolan, F.M., Parks, S., Dutton, G.N., Kelly, K., Keating, D., Sills, G.J. and Brodie, M.J. (2003) Peripheral retinal dysfunction in patients taking vigabatrin. Neurology, 61(12), pp. 1690-1694. (doi: 10.1212/01.WNL.0000098938.80082.25) (PMID:14694031)
Sills, G. J., Butler, E., Forrest, G., Ratnaraj, N., Patsalos, P. N. and Brodie, M. J. (2003) Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in Rat brain and retina. Epilepsia, 44(7), pp. 886-892. (doi: 10.1046/j.1528-1157.2003.04203.x) (PMID:12823570)
Kelly, K., Stephen, L. J., Sills, G. J. and Brodie, M. J. (2002) Topiramate in patients with learning disability and refractory epilepsy. Epilepsia, 43(4), pp. 399-402. (doi: 10.1046/j.1528-1157.2002.47401.x) (PMID:11952770)
Kwan, P., Sills, G. J., Butler, E., Gant, T. W., Meldrum, B. S. and Brodie, M. J. (2002) Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure. Epilepsia, 43(11), pp. 1318-1323. (doi: 10.1046/j.1528-1157.2002.156702.x) (PMID:12423380)
Santangeli, S., Sills, G. J., Thompson, G. G. and Brodie, M. J. (2002) Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. European Journal of Pharmacology, 438(1-2), pp. 63-68. (doi: 10.1016/S0014-2999(02)01297-9) (PMID:11906711)
Sills, G. J., Kwan, P., Butler, E., de Lange, E. C.M., van den Berg, D.-J. and Brodie, M. J. (2002) P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice. Epilepsy and Behavior, 3(5), pp. 427-432. (doi: 10.1016/S1525-5050(02)00511-5) (PMID:12609264)
Sills, G. J., Santangeli, S., Forrest, G. and Brodie, M. J. (2002) Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. Epilepsy Research, 49(3), pp. 247-254. (doi: 10.1016/S0920-1211(02)00049-9) (PMID:12076846)
Sills, G.J. and Brodie, M.J. (2001) Update on the mechanisms of action of antiepileptic drugs. Epileptic Disorders, 3(4), pp. 165-172. (PMID:11844711)
Kwan, P., Sills, G. J. and Brodie, M. J. (2001) The mechanisms of action of commonly used antiepileptic drugs. Pharmacology and Therapeutics, 90(1), pp. 21-34. (doi: 10.1016/S0163-7258(01)00122-X) (PMID:11448723)
Sills, G.J., Patsalos, P.N., Butler, E., Forrest, G., Ratnaraj, N. and Brodie, M.J. (2001) Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina. Neurology, 57(2), pp. 196-200. (doi: 10.1212/WNL.57.2.196) (PMID:11468302)
Sills, G. J., Leach, J. P. P., Kilpatrick, W. S., Fraser, C. M., Thompson, G. G. and Brodie, M. J. (2000) Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt. Epilepsia, 41(s1), pp. 30-34. (doi: 10.1111/j.1528-1157.2000.tb02168.x) (PMID:10768297)
Kwan, P., Sills, G. J., Kelly, K., Butler, E. and Brodie, M. J. (2000) Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Research, 42(2-3), pp. 191-195. (doi: 10.1016/S0920-1211(00)00180-7) (PMID:11074191)
Santangeli, S., McNeill, C., Sills, G. J. and Brodie, M. J. (2000) Simultaneous determination of remacemide hydrochloride and desglycinylremacemide (AR-R12495XX) in brain tissue by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 746(2), pp. 325-329. (doi: 10.1016/S0378-4347(00)00329-7) (PMID:11076087)
Fraser, C. M., Sills, G. J., Forrest, G., Thompson, G. G. and Brodie, M. J. (1999) Neurochemical studies with the anticonvulsant felbamate in mouse brain. Pharmacological Research, 40(3), pp. 257-261. (doi: 10.1006/phrs.1999.0511) (PMID:10479470)
Sills, G. J., Butler, E., Thompson, G. G. and Brodie, M. J. (1999) Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study. Seizure, 8(7), pp. 404-411. (doi: 10.1053/seiz.1999.0326) (PMID:10600581)
Stephen, L. J., Sills, G. J. and Brodie, M. J. (1998) Lamotrigine and topiramate may be a useful combination. Lancet, 351(9107), pp. 958-959. (doi: 10.1016/S0140-6736(05)60613-7) (PMID:9734949)
Wilson, E. A., Sills, G. J., Forrest, G. and Brodie, M. J. (1998) High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients. Epilepsy Research, 29(2), pp. 161-166. (doi: 10.1016/S0920-1211(97)00078-8) (PMID:9477149)
Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of gabapentin in mouse brain. Epilepsy Research, 27(3), pp. 175-180. (doi: 10.1016/S0920-1211(97)01034-6) (PMID:9237051)
Sills, G. J., Leach, J. P., Fraser, C. M., Forrest, G., Patsalos, P. N. and Brodie, M. J. (1997) Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. European Journal of Pharmacology, 325(1), pp. 35-40. (doi: 10.1016/S0014-2999(97)00105-2) (PMID:9151936)
Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain. British Journal of Pharmacology, 121(5), pp. 923-926. (doi: 10.1038/sj.bjp.0701219) (PMID:9222548) (PMCID:PMC1564774)
Leach, J. P., Sills, G. J., Majid, A., Butler, E., Carswell, A., Thompson, G. G. and Brodie, M. J. (1996) Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure, 5(3), pp. 229-234. (doi: 10.1016/S1059-1311(96)80041-0) (PMID:8902926)
Forrest, G., Sills, G. J., Leach, J. P. and Brodie, M. J. (1996) Determination of gabapentin in plasma by high-performance liquid chromatography. Journal of Chromatography B, 681(2), pp. 421-425. (doi: 10.1016/0378-4347(96)00074-6) (PMID:8811458)
Connick, J.H., Heywood, G.C., Sills, G.J., Thompson, G.G., Brodie, M.J. and Stone, T.W. (1992) Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity. General Pharmacology: The Vascular System, 23(2), pp. 235-239. (doi: 10.1016/0306-3623(92)90017-E) (PMID:1639238)
Book Sections
Hannah, J. A., Sills, G. J. and Brodie, M. J. (1995) Established and new antiepileptic drugs: an overview. In: Aldenkamp, A. P., Dreifuss, F. E., Reiner, W. O. and Suurmeijer, T. P.B.M. (eds.) Epilepsy in Children and Adolescents. CRC Press: Boca Raton, pp. 101-129. ISBN 0849376599