2023

O'Boyle, N., Douce, G. R. , Farrell, G., Rattray, N. J. W., Schembri, M. A., Roe, A. J. and Connolly, J. P.R. (2023) Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection. Proceedings of the National Academy of Sciences of the United States of America, 120(1), e2212175120. (doi: 10.1073/pnas.2212175120) (PMID:36574699) (PMCID:PMC9910484)

2021

Connolly, J. P.R., Turner, N. C.A., Hallam, J., Rimbi, P. T., Flett, T., McCormack, M. J., Roe, A. J. and O'Boyle, N. (2021) D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes. Microbiology, 167(10), 001093. (doi: 10.1099/mic.0.001093) (PMID:34623236)

Connolly, J. P.R., Roe, A. J. and O'Boyle, N. (2021) Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria. Critical Reviews in Microbiology, 47(1), pp. 126-140. (doi: 10.1080/1040841X.2020.1854172) (PMID:33332206)

2020

O'Boyle, N., Connolly, J. P.R., Tucker, N. P. and Roe, A. J. (2020) Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 117(36), pp. 22484-22493. (doi: 10.1073/pnas.2004977117) (PMID:32848072) (PMCID:PMC7486766)

Connolly, J. P.R., O'Boyle, N. and Roe, A. J. (2020) Widespread strain-specific distinctions in chromosomal binding dynamics of a highly conserved Escherichia coli transcription factor. mBio, 11, e01058-20. (doi: 10.1128/mBio.01058-20) (PMID:32576674) (PMCID:PMC7315121)

O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)

Fox, S., Goswami, C. , Holden, M., Connolly, J. P.R., Mordue, J., O'Boyle, N., Roe, A. , Connor, M., Leanord, A. and Evans, T. J. (2020) A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage. Scientific Reports, 10, 4135. (doi: 10.1038/s41598-020-61026-x) (PMID:32139768) (PMCID:PMC7058095)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

Connolly, J. P.R., O'Boyle, N., Turner, N., Browning, D. F. and Roe, A. J. (2019) Distinct intra-species virulence mechanisms regulated by a conserved transcription factor. Proceedings of the National Academy of Sciences of the United States of America, 116(39), pp. 19695-19704. (doi: 10.1073/pnas.1903461116) (PMID:31501343) (PMCID:PMC6765310)

Irvine, S., Bunk, B., Bayes, H. K., Spröer, C., Connolly, J. P.R., Six, A., Evans, T. J. , Roe, A. J. , Overmann, J. and Walker, D. (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)

McHugh, R. E., O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

2018

Scott, N. A. et al. (2018) Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Science Translational Medicine, 10(464), eaao4755. (doi: 10.1126/scitranslmed.aao4755) (PMID:30355800) (PMCID:PMC6548564)

Blum, S. E. et al. (2018) Postgenomics characterization of an essential genetic determinant of mammary pathogenic Escherichia coli. mBio, 9(2), e00423-18. (doi: 10.1128/mBio.00423-18) (PMID:29615502) (PMCID:PMC5885034)

O'Boyle, N., Connolly, J. P.R. and Roe, A. J. (2018) Tracking elusive cargo: Illuminating spatio-temporal type 3 effector protein dynamics using reporters. Cellular Microbiology, 20(1), e12797. (doi: 10.1111/cmi.12797) (PMID:29087624) (PMCID:PMC5765406)

Connolly, J. P.R. et al. (2018) Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nature Communications, 9, 4187. (doi: 10.1038/s41467-018-06701-4) (PMID:30305622) (PMCID:PMC6180029)

2017

Zambelloni, R., Connolly, J. P.R., Huerta Uribe, A. , Burgess, K., Marquez, R. and Roe, A. J. (2017) Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition. Molecular Microbiology, 105(4), pp. 606-619. (doi: 10.1111/mmi.13719) (PMID:28557017) (PMCID:PMC5575525)

2016

Connolly, J. P.R. and Roe, A. J. (2016) Intracellular D-serine accumulation promotes genetic diversity via modulated induction of RecA in enterohemorrhagic Escherichia coli. Journal of Bacteriology, 198(24), pp. 3318-3328. (doi: 10.1128/JB.00548-16) (PMID:27698085) (PMCID:PMC5116935)

Huerta-Uribe, A. et al. (2016) Identification and characterization of novel compounds blocking Shiga toxin expression in Escherichia coli O157:H7. Frontiers in Microbiology, 7, 1930. (doi: 10.3389/fmicb.2016.01930) (PMID:27965652) (PMCID:PMC5127787)

Palevsky, N., Shemer, B., Connolly, J. and Belkin, S. (2016) The highly conserved Escherichia coli transcription factor YhaJ regulates aromatic compound degradation. Frontiers in Microbiology, 7, 1490. (doi: 10.3389/fmicb.2016.01490) (PMID:27713734) (PMCID:PMC5031710)

Connolly, J. P.R. and Roe, A. J. (2016) When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment. Microbial Cell, 3(4), pp. 181-184. (doi: 10.15698/mic2016.04.494) (PMID:28357351) (PMCID:PMC5349093)

Connolly, J. P. R., Gabrielsen, M. , Goldstone, R. J., Grinter, R., Wang, D., Cogdell, R. J. , Walker, D. , Smith, D. G. E. and Roe, A. J. (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

2015

Connolly, J.P., Finlay, B.B. and Roe, A.J. (2015) From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli. Frontiers in Microbiology, 6, 568. (doi: 10.3389/fmicb.2015.00568) (PMID:26097473) (PMCID:PMC4456613)

Connolly, J. P.R., Goldstone, R. J., Burgess, K., Cogdell, R. J. , Beatson, S. A., Vollmer, W., Smith, D. G.E. and Roe, A. (2015) The host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9, pp. 1039-1051. (doi: 10.1038/ismej.2014.242) (PMID:25526369) (PMCID:PMC4366372)

2014

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi: 10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

Articles

O'Boyle, N., Douce, G. R. , Farrell, G., Rattray, N. J. W., Schembri, M. A., Roe, A. J. and Connolly, J. P.R. (2023) Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection. Proceedings of the National Academy of Sciences of the United States of America, 120(1), e2212175120. (doi: 10.1073/pnas.2212175120) (PMID:36574699) (PMCID:PMC9910484)

Connolly, J. P.R., Turner, N. C.A., Hallam, J., Rimbi, P. T., Flett, T., McCormack, M. J., Roe, A. J. and O'Boyle, N. (2021) D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes. Microbiology, 167(10), 001093. (doi: 10.1099/mic.0.001093) (PMID:34623236)

Connolly, J. P.R., Roe, A. J. and O'Boyle, N. (2021) Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria. Critical Reviews in Microbiology, 47(1), pp. 126-140. (doi: 10.1080/1040841X.2020.1854172) (PMID:33332206)

O'Boyle, N., Connolly, J. P.R., Tucker, N. P. and Roe, A. J. (2020) Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 117(36), pp. 22484-22493. (doi: 10.1073/pnas.2004977117) (PMID:32848072) (PMCID:PMC7486766)

Connolly, J. P.R., O'Boyle, N. and Roe, A. J. (2020) Widespread strain-specific distinctions in chromosomal binding dynamics of a highly conserved Escherichia coli transcription factor. mBio, 11, e01058-20. (doi: 10.1128/mBio.01058-20) (PMID:32576674) (PMCID:PMC7315121)

O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)

Fox, S., Goswami, C. , Holden, M., Connolly, J. P.R., Mordue, J., O'Boyle, N., Roe, A. , Connor, M., Leanord, A. and Evans, T. J. (2020) A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage. Scientific Reports, 10, 4135. (doi: 10.1038/s41598-020-61026-x) (PMID:32139768) (PMCID:PMC7058095)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

Connolly, J. P.R., O'Boyle, N., Turner, N., Browning, D. F. and Roe, A. J. (2019) Distinct intra-species virulence mechanisms regulated by a conserved transcription factor. Proceedings of the National Academy of Sciences of the United States of America, 116(39), pp. 19695-19704. (doi: 10.1073/pnas.1903461116) (PMID:31501343) (PMCID:PMC6765310)

Irvine, S., Bunk, B., Bayes, H. K., Spröer, C., Connolly, J. P.R., Six, A., Evans, T. J. , Roe, A. J. , Overmann, J. and Walker, D. (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)

McHugh, R. E., O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

Scott, N. A. et al. (2018) Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Science Translational Medicine, 10(464), eaao4755. (doi: 10.1126/scitranslmed.aao4755) (PMID:30355800) (PMCID:PMC6548564)

Blum, S. E. et al. (2018) Postgenomics characterization of an essential genetic determinant of mammary pathogenic Escherichia coli. mBio, 9(2), e00423-18. (doi: 10.1128/mBio.00423-18) (PMID:29615502) (PMCID:PMC5885034)

O'Boyle, N., Connolly, J. P.R. and Roe, A. J. (2018) Tracking elusive cargo: Illuminating spatio-temporal type 3 effector protein dynamics using reporters. Cellular Microbiology, 20(1), e12797. (doi: 10.1111/cmi.12797) (PMID:29087624) (PMCID:PMC5765406)

Connolly, J. P.R. et al. (2018) Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nature Communications, 9, 4187. (doi: 10.1038/s41467-018-06701-4) (PMID:30305622) (PMCID:PMC6180029)

Zambelloni, R., Connolly, J. P.R., Huerta Uribe, A. , Burgess, K., Marquez, R. and Roe, A. J. (2017) Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition. Molecular Microbiology, 105(4), pp. 606-619. (doi: 10.1111/mmi.13719) (PMID:28557017) (PMCID:PMC5575525)

Connolly, J. P.R. and Roe, A. J. (2016) Intracellular D-serine accumulation promotes genetic diversity via modulated induction of RecA in enterohemorrhagic Escherichia coli. Journal of Bacteriology, 198(24), pp. 3318-3328. (doi: 10.1128/JB.00548-16) (PMID:27698085) (PMCID:PMC5116935)

Huerta-Uribe, A. et al. (2016) Identification and characterization of novel compounds blocking Shiga toxin expression in Escherichia coli O157:H7. Frontiers in Microbiology, 7, 1930. (doi: 10.3389/fmicb.2016.01930) (PMID:27965652) (PMCID:PMC5127787)

Palevsky, N., Shemer, B., Connolly, J. and Belkin, S. (2016) The highly conserved Escherichia coli transcription factor YhaJ regulates aromatic compound degradation. Frontiers in Microbiology, 7, 1490. (doi: 10.3389/fmicb.2016.01490) (PMID:27713734) (PMCID:PMC5031710)

Connolly, J. P.R. and Roe, A. J. (2016) When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment. Microbial Cell, 3(4), pp. 181-184. (doi: 10.15698/mic2016.04.494) (PMID:28357351) (PMCID:PMC5349093)

Connolly, J. P. R., Gabrielsen, M. , Goldstone, R. J., Grinter, R., Wang, D., Cogdell, R. J. , Walker, D. , Smith, D. G. E. and Roe, A. J. (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

Connolly, J.P., Finlay, B.B. and Roe, A.J. (2015) From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli. Frontiers in Microbiology, 6, 568. (doi: 10.3389/fmicb.2015.00568) (PMID:26097473) (PMCID:PMC4456613)

Connolly, J. P.R., Goldstone, R. J., Burgess, K., Cogdell, R. J. , Beatson, S. A., Vollmer, W., Smith, D. G.E. and Roe, A. (2015) The host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9, pp. 1039-1051. (doi: 10.1038/ismej.2014.242) (PMID:25526369) (PMCID:PMC4366372)

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi: 10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)