2023

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)

Dannhorn, A. et al. (2023) Targeted desorption electrospray ionization mass spectrometry imaging for drug distribution, toxicity, and tissue classification studies. Metabolites, 13(3), 377. (doi: 10.3390/metabo13030377) (PMID:36984817) (PMCID:PMC10060000)

2022

Dannhorn, A., Swales, J. G., Hamm, G., Strittmatter, N., Kudo, H., Maglennon, G., Goodwin, R. J.A. and Takats, Z. (2022) Evaluation of formalin-fixed and FFPE tissues for spatially resolved metabolomics and drug distribution studies. Pharmaceuticals, 15(11), 1307. (doi: 10.3390/ph15111307) (PMID:36355479) (PMCID:PMC9697942)

Prag, H. A. et al. (2022) Ischemia-selective cardioprotection by malonate for ischemia/reperfusion injury. Circulation Research, 131(6), pp. 528-541. (doi: 10.1161/CIRCRESAHA.121.320717) (PMID:35959683) (PMCID:PMC9426742)

Steven, R. T., Niehaus, M., Taylor, A. J., Nasif, A., Elia, E., Goodwin, R. J.A., Takats, Z. and Bunch, J. (2022) Atmospheric-pressure infrared laser-ablation plasma-postionization mass spectrometry imaging of formalin-fixed paraffin-embedded (FFPE) and fresh-frozen tissue sections with no sample preparation. Analytical Chemistry, 94(28), pp. 9970-9974. (doi: 10.1021/acs.analchem.2c00690) (PMID:35798333) (PMCID:PMC9310026)

Dannhorn, A., Kazanc, E., Hamm, G., Swales, J. G., Strittmatter, N., Maglennon, G., Goodwin, R. J.A. and Takats, Z. (2022) Correlating mass spectrometry imaging and liquid chromatography-tandem mass spectrometry for tissue-based pharmacokinetic studies. Metabolites, 12(3), 261. (doi: 10.3390/metabo12030261) (PMID:35323705) (PMCID:PMC8954739)

Strittmatter, N. et al. (2022) Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging. Analytical Chemistry, 94(3), pp. 1795-1803. (doi: 10.1021/acs.analchem.1c04579) (PMID:35005896)

Strittmatter, N. et al. (2022) Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution. Theranostics, 12(5), pp. 2162-2174. (doi: 10.7150/thno.68000) (PMID:35265205) (PMCID:PMC8899579)

2021

Strittmatter, N. et al. (2021) Holistic characterization of a Salmonella typhimurium infection model using integrated molecular imaging. Journal of the American Society for Mass Spectrometry, 32(12), pp. 2791-2802. (doi: 10.1021/jasms.1c00240) (PMID:34767352)

de Jesus, J. M. et al. (2021) Correlative imaging of trace elements and intact molecular species in a single-tissue sample at the 50 μm scale. Analytical Chemistry, 93(40), pp. 13450-13458. (doi: 10.1021/acs.analchem.1c01927) (PMID:34597513)

Flint, L. E., Hamm, G., Ready, J. D., Ling, S., Duckett, C. J., Cross, N. A., Cole, L. M., Smith, D. P., Goodwin, R. J.A. and Clench, M. R. (2021) Comparison of osteosarcoma aggregated tumour models with human tissue by multimodal mass spectrometry imaging. Metabolites, 11(8), 506. (doi: 10.3390/metabo11080506)

Strittmatter, N. et al. (2021) Method to investigate the distribution of water-soluble drug-delivery systems in fresh frozen tissues using imaging mass cytometry. Analytical Chemistry, 93(8), pp. 3742-3749. (doi: 10.1021/acs.analchem.0c03908) (PMID:33606520)

Race, A. M. et al. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93(6), pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726) (PMID:33534548)

Dannhorn, A. et al. (2021) Evaluation of UV-C decontamination of clinical tissue sections for spatially resolved analysis by mass spectrometry imaging (MSI). Analytical Chemistry, 93(5), pp. 2767-2775. (doi: 10.1021/acs.analchem.0c03430) (PMID:33474935)

Murta, T. et al. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93(4), pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179) (PMID:33395266)

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)

2020

Shariatgorji, R., Nilsson, A., Strittmatter, N., Vallianatou, T., Zhang, X., Svenningsson, P., Goodwin, R. J.A. and Andrén, P. E. (2020) Bromopyrylium derivatization facilitates identification by mass spectrometry imaging of monoamine neurotransmitters and small molecule neuroactive compounds. Journal of the American Society for Mass Spectrometry, 31(12), pp. 2553-2557. (doi: 10.1021/jasms.0c00166) (PMID:32633532)

Flint, L. E., Hamm, G., Ready, J. D., Ling, S., Duckett, C. J., Cross, N. A., Cole, L. M., Smith, D. P., Goodwin, R. J.A. and Clench, M. R. (2020) Characterization of an aggregated three-dimensional cell culture model by multimodal mass spectrometry imaging. Analytical Chemistry, 92(18), pp. 12538-12547. (doi: 10.1021/acs.analchem.0c02389) (PMID:32786495) (PMCID:PMC7497704)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

2017

HULME, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi: 10.1038/s41598-017-03100-5) (PMID:28584281) (PMCID:PMC5459799)

2015

Goodwin, R. I.S., McGarrity, A., Sheehan, R., James, T. E., Miller, H., Stephens, J., Watkins, S., McConnachie, A. , Goodall, A. H. and Oldroyd, K. G. (2015) Variation in thromboxane B2 concentrations in serum and plasma in patients taking regular aspirin before and after clopidogrel therapy. Platelets, 26(1), pp. 17-24. (doi: 10.3109/09537104.2013.870334) (PMID:24433337)

2011

Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P. and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi: 10.1002/rcm.4939)

Brown, A. R. et al. (2011) Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 21(1), pp. 137-140. (doi: 10.1016/j.bmcl.2010.11.054) (PMID:21129964)

Cappell, J., Karim, M. and Goodwin, R. (2011) Conference Report: Seventh Exploratory Measurement Science Group Symposium. Bioanalysis, 3(1), pp. 17-19. (doi: 10.4155/BIO.10.176)

2010

Goodwin, R.J., MacIntyre, L., Watson, D.G., Scullion, S.P. and Pitt, A.R. (2010) A solvent-free matrix application method for matrix-assisted laser desorption/ionization imaging of small molecules. Rapid Communications in Mass Spectrometry, 24(11), pp. 1682-1686. (doi: 10.1002/rcm.4567) (PMID:20486266)

Goodwin, R.J.A. and Pitt, A.R. (2010) Mass spectrometry imaging of pharmacological compounds in tissue sections. Bioanalysis, 2(2), pp. 279-293. (doi: 10.4155/bio.09.180)

Goodwin, R.J.A., Scullion, P., MacIntyre, L., Watson, D. G. and Pitt, A.R. (2010) Use of a Solvent-Free Dry Matrix Coating for Quantitative Matrix-Assisted Laser Desorption Ionization Imaging of 4-Bromophenyl-1,4-diazabicyclo(3.2.2)nonane-4-carboxylate in Rat Brain and Quantitative Analysis of the Drug from Laser Microdissected Tissue Regions. Analytical Chemistry, 82(9), pp. 3868-3873. (doi: 10.1021/ac100398y)

2008

Goodwin, R.J.A., Dungworth, J.C., Cobb, S.R. and Pitt, A.R. (2008) Time-dependent evolution of tissue markers by MALDI-MS imaging. Proteomics, 8(18), pp. 3801-3808. (doi: 10.1002/pmic.200800201)

Goodwin, R.J.A., Pennington, S.R. and Pitt, A.R. (2008) Protein and peptides in pictures: imaging with MALDI mass spectrometry. Proteomics, 8(18), pp. 3785-3800. (doi: 10.1002/pmic.200800320)

Articles

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)

Dannhorn, A. et al. (2023) Targeted desorption electrospray ionization mass spectrometry imaging for drug distribution, toxicity, and tissue classification studies. Metabolites, 13(3), 377. (doi: 10.3390/metabo13030377) (PMID:36984817) (PMCID:PMC10060000)

Dannhorn, A., Swales, J. G., Hamm, G., Strittmatter, N., Kudo, H., Maglennon, G., Goodwin, R. J.A. and Takats, Z. (2022) Evaluation of formalin-fixed and FFPE tissues for spatially resolved metabolomics and drug distribution studies. Pharmaceuticals, 15(11), 1307. (doi: 10.3390/ph15111307) (PMID:36355479) (PMCID:PMC9697942)

Prag, H. A. et al. (2022) Ischemia-selective cardioprotection by malonate for ischemia/reperfusion injury. Circulation Research, 131(6), pp. 528-541. (doi: 10.1161/CIRCRESAHA.121.320717) (PMID:35959683) (PMCID:PMC9426742)

Steven, R. T., Niehaus, M., Taylor, A. J., Nasif, A., Elia, E., Goodwin, R. J.A., Takats, Z. and Bunch, J. (2022) Atmospheric-pressure infrared laser-ablation plasma-postionization mass spectrometry imaging of formalin-fixed paraffin-embedded (FFPE) and fresh-frozen tissue sections with no sample preparation. Analytical Chemistry, 94(28), pp. 9970-9974. (doi: 10.1021/acs.analchem.2c00690) (PMID:35798333) (PMCID:PMC9310026)

Dannhorn, A., Kazanc, E., Hamm, G., Swales, J. G., Strittmatter, N., Maglennon, G., Goodwin, R. J.A. and Takats, Z. (2022) Correlating mass spectrometry imaging and liquid chromatography-tandem mass spectrometry for tissue-based pharmacokinetic studies. Metabolites, 12(3), 261. (doi: 10.3390/metabo12030261) (PMID:35323705) (PMCID:PMC8954739)

Strittmatter, N. et al. (2022) Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging. Analytical Chemistry, 94(3), pp. 1795-1803. (doi: 10.1021/acs.analchem.1c04579) (PMID:35005896)

Strittmatter, N. et al. (2022) Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution. Theranostics, 12(5), pp. 2162-2174. (doi: 10.7150/thno.68000) (PMID:35265205) (PMCID:PMC8899579)

Strittmatter, N. et al. (2021) Holistic characterization of a Salmonella typhimurium infection model using integrated molecular imaging. Journal of the American Society for Mass Spectrometry, 32(12), pp. 2791-2802. (doi: 10.1021/jasms.1c00240) (PMID:34767352)

de Jesus, J. M. et al. (2021) Correlative imaging of trace elements and intact molecular species in a single-tissue sample at the 50 μm scale. Analytical Chemistry, 93(40), pp. 13450-13458. (doi: 10.1021/acs.analchem.1c01927) (PMID:34597513)

Flint, L. E., Hamm, G., Ready, J. D., Ling, S., Duckett, C. J., Cross, N. A., Cole, L. M., Smith, D. P., Goodwin, R. J.A. and Clench, M. R. (2021) Comparison of osteosarcoma aggregated tumour models with human tissue by multimodal mass spectrometry imaging. Metabolites, 11(8), 506. (doi: 10.3390/metabo11080506)

Strittmatter, N. et al. (2021) Method to investigate the distribution of water-soluble drug-delivery systems in fresh frozen tissues using imaging mass cytometry. Analytical Chemistry, 93(8), pp. 3742-3749. (doi: 10.1021/acs.analchem.0c03908) (PMID:33606520)

Race, A. M. et al. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93(6), pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726) (PMID:33534548)

Dannhorn, A. et al. (2021) Evaluation of UV-C decontamination of clinical tissue sections for spatially resolved analysis by mass spectrometry imaging (MSI). Analytical Chemistry, 93(5), pp. 2767-2775. (doi: 10.1021/acs.analchem.0c03430) (PMID:33474935)

Murta, T. et al. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93(4), pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179) (PMID:33395266)

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)

Shariatgorji, R., Nilsson, A., Strittmatter, N., Vallianatou, T., Zhang, X., Svenningsson, P., Goodwin, R. J.A. and Andrén, P. E. (2020) Bromopyrylium derivatization facilitates identification by mass spectrometry imaging of monoamine neurotransmitters and small molecule neuroactive compounds. Journal of the American Society for Mass Spectrometry, 31(12), pp. 2553-2557. (doi: 10.1021/jasms.0c00166) (PMID:32633532)

Flint, L. E., Hamm, G., Ready, J. D., Ling, S., Duckett, C. J., Cross, N. A., Cole, L. M., Smith, D. P., Goodwin, R. J.A. and Clench, M. R. (2020) Characterization of an aggregated three-dimensional cell culture model by multimodal mass spectrometry imaging. Analytical Chemistry, 92(18), pp. 12538-12547. (doi: 10.1021/acs.analchem.0c02389) (PMID:32786495) (PMCID:PMC7497704)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

HULME, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi: 10.1038/s41598-017-03100-5) (PMID:28584281) (PMCID:PMC5459799)

Goodwin, R. I.S., McGarrity, A., Sheehan, R., James, T. E., Miller, H., Stephens, J., Watkins, S., McConnachie, A. , Goodall, A. H. and Oldroyd, K. G. (2015) Variation in thromboxane B2 concentrations in serum and plasma in patients taking regular aspirin before and after clopidogrel therapy. Platelets, 26(1), pp. 17-24. (doi: 10.3109/09537104.2013.870334) (PMID:24433337)

Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P. and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi: 10.1002/rcm.4939)

Brown, A. R. et al. (2011) Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 21(1), pp. 137-140. (doi: 10.1016/j.bmcl.2010.11.054) (PMID:21129964)

Cappell, J., Karim, M. and Goodwin, R. (2011) Conference Report: Seventh Exploratory Measurement Science Group Symposium. Bioanalysis, 3(1), pp. 17-19. (doi: 10.4155/BIO.10.176)

Goodwin, R.J., MacIntyre, L., Watson, D.G., Scullion, S.P. and Pitt, A.R. (2010) A solvent-free matrix application method for matrix-assisted laser desorption/ionization imaging of small molecules. Rapid Communications in Mass Spectrometry, 24(11), pp. 1682-1686. (doi: 10.1002/rcm.4567) (PMID:20486266)

Goodwin, R.J.A. and Pitt, A.R. (2010) Mass spectrometry imaging of pharmacological compounds in tissue sections. Bioanalysis, 2(2), pp. 279-293. (doi: 10.4155/bio.09.180)

Goodwin, R.J.A., Scullion, P., MacIntyre, L., Watson, D. G. and Pitt, A.R. (2010) Use of a Solvent-Free Dry Matrix Coating for Quantitative Matrix-Assisted Laser Desorption Ionization Imaging of 4-Bromophenyl-1,4-diazabicyclo(3.2.2)nonane-4-carboxylate in Rat Brain and Quantitative Analysis of the Drug from Laser Microdissected Tissue Regions. Analytical Chemistry, 82(9), pp. 3868-3873. (doi: 10.1021/ac100398y)

Goodwin, R.J.A., Dungworth, J.C., Cobb, S.R. and Pitt, A.R. (2008) Time-dependent evolution of tissue markers by MALDI-MS imaging. Proteomics, 8(18), pp. 3801-3808. (doi: 10.1002/pmic.200800201)

Goodwin, R.J.A., Pennington, S.R. and Pitt, A.R. (2008) Protein and peptides in pictures: imaging with MALDI mass spectrometry. Proteomics, 8(18), pp. 3785-3800. (doi: 10.1002/pmic.200800320)