Dr Margus Varjak

  • Affiliate (Institute of Infection Immunity & Inflammation)

email: Margus.Varjak@glasgow.ac.uk

MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, 464 Bearsden Road, Glasgow, G61 1QH

ORCID iDhttps://orcid.org/0000-0003-2608-5148

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010
Number of items: 28.

2021

Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)

Almire, F., Terhzaz, S. , Terry, S., McFarlane, M. , Gestuveo, R. J., Szemiel, A. M., Varjak, M. , McDonald, A., Kohl, A. and Pondeville, E. (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. PLoS Pathogens, 17(9), e1009870. (doi: 10.1371/journal.ppat.1009870) (PMID:34473801) (PMCID:PMC8412342)

Scherer, C. et al. (2021) An Aedes aegypti-derived Ago2 knockout cell line to investigate arbovirus infections. Viruses, 13(6), 1066. (doi: 10.3390/v13061066) (PMID:34205194) (PMCID:PMC8227176)

Gestuveo, R. J., Royle, J., Donald, C. L. , Lamont, D. J., Hutchinson, E. C. , Merits, A., Kohl, A. and Varjak, M. (2021) Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection. Nature Communications, 12, 2766. (doi: 10.1038/s41467-021-22966-8) (PMID:33986255) (PMCID:PMC8119459)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

2020

Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)

Varjak, M. , Gestuveo, R. J., Burchmore, R. , Schnettler, E. and Kohl, A. (2020) aBravo is a novel Aedes aegypti antiviral protein that interacts with, but acts independently of, the exogenous siRNA pathway effector Dicer 2. Viruses, 12(7), 748. (doi: 10.3390/v12070748)

Royle, J. , Ramírez-Santana, C., Akpunarlieva, S., Donald, C. L. , Gestuveo, R. J., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-regulated protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. Viruses, 12(5), 524. (doi: 10.3390/v12050524)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)

2018

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Varjak, M. , Leggewie, M. and Schnettler, E. (2018) The antiviral piRNA response in mosquitoes? Journal of General Virology, 99(12), pp. 1551-1562. (doi: 10.1099/jgv.0.001157) (PMID:30372405)

Mutso, M. et al. (2018) Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus. Viruses, 10(5), 226. (doi: 10.3390/v10050226) (PMID:29702546)

Varjak, M. , Dietrich, I., Sreenu, V. B. , Till, B. E., Merits, A., Kohl, A. and Schnettler, E. (2018) Spindle-E acts antivirally against alphaviruses in mosquito cells. Viruses, 10(2), 88. (doi: 10.3390/v10020088) (PMID:29463033) (PMCID:PMC5850395)

Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi: 10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)

2017

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Mottram, T. J., Li, P. , Dietrich, I., Shi, X. , Brennan, B. , Varjak, M. and Kohl, A. (2017) Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. PLoS Neglected Tropical Diseases, 11(12), e0006155. (doi: 10.1371/journal.pntd.0006155) (PMID:29267287) (PMCID:PMC5764413)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Karlas, A. et al. (2016) A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7, p. 11320. (PMID:27177310) (PMCID:PMC4865845)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi: 10.1371/journal.ppat.1005536) (PMID:27089431) (PMCID:PMC4835223)

2015

Utt, A., Das, P. K., Varjak, M. , Lulla, V., Lulla, A. and Merits, A. (2015) Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. Journal of Virology, 89(6), pp. 3145-62. (PMID:25552719) (PMCID:PMC4337533)

2013

Varjak, M. , Saul, S., Arike, L., Lulla, A., Peil, L. and Merits, A. (2013) Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. Journal of Virology, 87(18), pp. 10295-10312. (doi: 10.1128/JVI.01105-13) (PMID:23864636) (PMCID:PMC3754020)

2012

Panas, M. D., Varjak, M. , Lulla, A., Eng, K. E., Merits, A., Karlsson Hedestam, G. B. and McInerney, G. M. (2012) Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Molecular Biology of the Cell, 23(24), pp. 4701-4712. (doi: 10.1091/mbc.E12-08-0619) (PMID:23087212) (PMCID:PMC3521679)

Rodriguez-Andres, J. et al. (2012) Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus. PLoS Pathogens, 8(11), e1002977. (doi: 10.1371/journal.ppat.1002977) (PMID:23144608) (PMCID:PMC3493465)

2011

Pohjala, L., Utt, A., Varjak, M. , Lulla, A., Merits, A., Ahola, T. and Tammela, P. (2011) Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS ONE, 6(12), e28923. (doi: 10.1371/journal.pone.0028923) (PMID:22205980) (PMCID:PMC3242765)

2010

Varjak, M. , Zusinaite, E. and Merits, A. (2010) Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region. Journal of Virology, 84(5), pp. 2352-2364. (doi: 10.1128/JVI.01540-09) (PMID:20015978) (PMCID:PMC2820926)

This list was generated on Thu Dec 9 12:28:35 2021 GMT.
Jump to: Articles
Number of items: 28.

Articles

Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)

Almire, F., Terhzaz, S. , Terry, S., McFarlane, M. , Gestuveo, R. J., Szemiel, A. M., Varjak, M. , McDonald, A., Kohl, A. and Pondeville, E. (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. PLoS Pathogens, 17(9), e1009870. (doi: 10.1371/journal.ppat.1009870) (PMID:34473801) (PMCID:PMC8412342)

Scherer, C. et al. (2021) An Aedes aegypti-derived Ago2 knockout cell line to investigate arbovirus infections. Viruses, 13(6), 1066. (doi: 10.3390/v13061066) (PMID:34205194) (PMCID:PMC8227176)

Gestuveo, R. J., Royle, J., Donald, C. L. , Lamont, D. J., Hutchinson, E. C. , Merits, A., Kohl, A. and Varjak, M. (2021) Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection. Nature Communications, 12, 2766. (doi: 10.1038/s41467-021-22966-8) (PMID:33986255) (PMCID:PMC8119459)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)

Varjak, M. , Gestuveo, R. J., Burchmore, R. , Schnettler, E. and Kohl, A. (2020) aBravo is a novel Aedes aegypti antiviral protein that interacts with, but acts independently of, the exogenous siRNA pathway effector Dicer 2. Viruses, 12(7), 748. (doi: 10.3390/v12070748)

Royle, J. , Ramírez-Santana, C., Akpunarlieva, S., Donald, C. L. , Gestuveo, R. J., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-regulated protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. Viruses, 12(5), 524. (doi: 10.3390/v12050524)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Varjak, M. , Leggewie, M. and Schnettler, E. (2018) The antiviral piRNA response in mosquitoes? Journal of General Virology, 99(12), pp. 1551-1562. (doi: 10.1099/jgv.0.001157) (PMID:30372405)

Mutso, M. et al. (2018) Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus. Viruses, 10(5), 226. (doi: 10.3390/v10050226) (PMID:29702546)

Varjak, M. , Dietrich, I., Sreenu, V. B. , Till, B. E., Merits, A., Kohl, A. and Schnettler, E. (2018) Spindle-E acts antivirally against alphaviruses in mosquito cells. Viruses, 10(2), 88. (doi: 10.3390/v10020088) (PMID:29463033) (PMCID:PMC5850395)

Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi: 10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Mottram, T. J., Li, P. , Dietrich, I., Shi, X. , Brennan, B. , Varjak, M. and Kohl, A. (2017) Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. PLoS Neglected Tropical Diseases, 11(12), e0006155. (doi: 10.1371/journal.pntd.0006155) (PMID:29267287) (PMCID:PMC5764413)

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Karlas, A. et al. (2016) A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7, p. 11320. (PMID:27177310) (PMCID:PMC4865845)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi: 10.1371/journal.ppat.1005536) (PMID:27089431) (PMCID:PMC4835223)

Utt, A., Das, P. K., Varjak, M. , Lulla, V., Lulla, A. and Merits, A. (2015) Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. Journal of Virology, 89(6), pp. 3145-62. (PMID:25552719) (PMCID:PMC4337533)

Varjak, M. , Saul, S., Arike, L., Lulla, A., Peil, L. and Merits, A. (2013) Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. Journal of Virology, 87(18), pp. 10295-10312. (doi: 10.1128/JVI.01105-13) (PMID:23864636) (PMCID:PMC3754020)

Panas, M. D., Varjak, M. , Lulla, A., Eng, K. E., Merits, A., Karlsson Hedestam, G. B. and McInerney, G. M. (2012) Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Molecular Biology of the Cell, 23(24), pp. 4701-4712. (doi: 10.1091/mbc.E12-08-0619) (PMID:23087212) (PMCID:PMC3521679)

Rodriguez-Andres, J. et al. (2012) Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus. PLoS Pathogens, 8(11), e1002977. (doi: 10.1371/journal.ppat.1002977) (PMID:23144608) (PMCID:PMC3493465)

Pohjala, L., Utt, A., Varjak, M. , Lulla, A., Merits, A., Ahola, T. and Tammela, P. (2011) Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS ONE, 6(12), e28923. (doi: 10.1371/journal.pone.0028923) (PMID:22205980) (PMCID:PMC3242765)

Varjak, M. , Zusinaite, E. and Merits, A. (2010) Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region. Journal of Virology, 84(5), pp. 2352-2364. (doi: 10.1128/JVI.01540-09) (PMID:20015978) (PMCID:PMC2820926)

This list was generated on Thu Dec 9 12:28:35 2021 GMT.

Research datasets

Jump to: 2021 | 2020 | 2018
Number of items: 9.

2021

Gestuveo, R., Parry, R., Dickson, L., Lequime, S., Sreenu, V. B., Arnold, M., Khromykh, A. A., Schnettler, E., Lambrechts, L., Varjak, M. and Kohl, A. (2021) Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs. [Data Collection]

Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]

Almire, F., Terhzaz, S. , Terry, S., McFarlane, M., Gestuveo, R., Sziemel, A. M., Varjak, M. , Mcdonald, A., Kohl, A. and Pondeville, E. (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. [Data Collection]

Scherer, C., Knowles, J., Vattipally, S. , Fredericks, A., Fuss, J., Maringer, K., Fernandez-Sesma, A., Merits, A., Varjak, M. , Kohl, A. and Schnettler, E. (2021) An Aedes aegypti-derived Ago2 knockout cell line to investigate arbovirus infections. [Data Collection]

Gestuveo, R., Royle, J. , Donald, C. , Merits, A., Kohl, A. and Varjak, M. (2021) Analysis of the Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for the establishment of infection. [Data Collection]

2020

Sanchez Velazquez, R., de Lorenzo, G., Tandavanitj, R. , Setthapramote, C., Bredenbeek, P., Bozzacco, L., MacDonald, M., Clark, J., Rice, C., Patel, A. , Kohl, A. and Varjak, M. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. [Data Collection]

Royle, J., Ramírez-Santana, C., Akpunarlieva, S., Donald, C. , Gestuveo, R., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-Regulated Protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. [Data Collection]

Varjak, M. , Rommel, G., Schnettler, E. and Kohl, A. (2020) aBravo is a novel Aedes aegypti antiviral protein that interacts with, but acts independently of, the exogenous siRNA pathway effector Dicer 2. [Data Collection]

2018

Donald, C. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B., Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. [Data Collection]

This list was generated on Thu Dec 9 11:57:09 2021 GMT.