Dr James Connolly

  • Honorary Research Fellow (Institute of Infection Immunity & Inflammation)

email: James.Connolly@glasgow.ac.uk

Room B216, Infection Immunity & Immunology, Sir Graeme Davies Building, G12 8TA

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014
Number of items: 24.

2021

Connolly, J. P.R., Turner, N. C.A., Hallam, J., Rimbi, P. T., Flett, T., McCormack, M. J., Roe, A. J. and O'Boyle, N. (2021) D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes. Microbiology, 167(10), 001093. (doi: 10.1099/mic.0.001093) (PMID:34623236)

Connolly, J. P.R., Roe, A. J. and O'Boyle, N. (2021) Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria. Critical Reviews in Microbiology, 47(1), pp. 126-140. (doi: 10.1080/1040841X.2020.1854172) (PMID:33332206)

2020

O'Boyle, N., Connolly, J. P.R., Tucker, N. P. and Roe, A. J. (2020) Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 117(36), pp. 22484-22493. (doi: 10.1073/pnas.2004977117) (PMID:32848072) (PMCID:PMC7486766)

Connolly, J. P.R., O'Boyle, N. and Roe, A. J. (2020) Widespread strain-specific distinctions in chromosomal binding dynamics of a highly conserved Escherichia coli transcription factor. mBio, 11, e01058-20. (doi: 10.1128/mBio.01058-20) (PMID:32576674) (PMCID:PMC7315121)

O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)

Fox, S., Goswami, C. , Holden, M., Connolly, J. P.R., Mordue, J., O'Boyle, N., Roe, A. , Connor, M., Leanord, A. and Evans, T. J. (2020) A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage. Scientific Reports, 10, 4135. (doi: 10.1038/s41598-020-61026-x) (PMID:32139768) (PMCID:PMC7058095)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

Connolly, J. P.R., O'Boyle, N., Turner, N., Browning, D. F. and Roe, A. J. (2019) Distinct intra-species virulence mechanisms regulated by a conserved transcription factor. Proceedings of the National Academy of Sciences of the United States of America, 116(39), pp. 19695-19704. (doi: 10.1073/pnas.1903461116) (PMID:31501343) (PMCID:PMC6765310)

Irvine, S., Bunk, B., Bayes, H. K., Spröer, C., Connolly, J. P.R., Six, A., Evans, T. J. , Roe, A. J. , Overmann, J. and Walker, D. (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)

McHugh, R. E., O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

2018

Scott, N. A. et al. (2018) Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Science Translational Medicine, 10(464), eaao4755. (doi: 10.1126/scitranslmed.aao4755) (PMID:30355800) (PMCID:PMC6548564)

Blum, S. E. et al. (2018) Postgenomics characterization of an essential genetic determinant of mammary pathogenic Escherichia coli. mBio, 9(2), e00423-18. (doi: 10.1128/mBio.00423-18) (PMID:29615502) (PMCID:PMC5885034)

O'Boyle, N., Connolly, J. P.R. and Roe, A. J. (2018) Tracking elusive cargo: Illuminating spatio-temporal type 3 effector protein dynamics using reporters. Cellular Microbiology, 20(1), e12797. (doi: 10.1111/cmi.12797) (PMID:29087624) (PMCID:PMC5765406)

Connolly, J. P.R. et al. (2018) Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nature Communications, 9, 4187. (doi: 10.1038/s41467-018-06701-4) (PMID:30305622) (PMCID:PMC6180029)

2017

Zambelloni, R., Connolly, J. P.R., Huerta Uribe, A., Burgess, K., Marquez, R. and Roe, A. J. (2017) Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition. Molecular Microbiology, 105(4), pp. 606-619. (doi: 10.1111/mmi.13719) (PMID:28557017) (PMCID:PMC5575525)

2016

Connolly, J. P.R. and Roe, A. J. (2016) Intracellular D-serine accumulation promotes genetic diversity via modulated induction of RecA in enterohemorrhagic Escherichia coli. Journal of Bacteriology, 198(24), pp. 3318-3328. (doi: 10.1128/JB.00548-16) (PMID:27698085) (PMCID:PMC5116935)

Huerta-Uribe, A. et al. (2016) Identification and characterization of novel compounds blocking Shiga toxin expression in Escherichia coli O157:H7. Frontiers in Microbiology, 7, 1930. (doi: 10.3389/fmicb.2016.01930) (PMID:27965652) (PMCID:PMC5127787)

Palevsky, N., Shemer, B., Connolly, J. and Belkin, S. (2016) The highly conserved Escherichia coli transcription factor YhaJ regulates aromatic compound degradation. Frontiers in Microbiology, 7, 1490. (doi: 10.3389/fmicb.2016.01490) (PMID:27713734) (PMCID:PMC5031710)

Connolly, J. P.R. and Roe, A. J. (2016) When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment. Microbial Cell, 3(4), pp. 181-184. (doi: 10.15698/mic2016.04.494) (PMID:28357351) (PMCID:PMC5349093)

Connolly, J. P. R., Gabrielsen, M. , Goldstone, R. J., Grinter, R., Wang, D., Cogdell, R. J. , Walker, D. , Smith, D. G. E. and Roe, A. J. (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

2015

Connolly, J.P., Finlay, B.B. and Roe, A.J. (2015) From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli. Frontiers in Microbiology, 6, 568. (doi: 10.3389/fmicb.2015.00568) (PMID:26097473) (PMCID:PMC4456613)

Connolly, J. P.R., Goldstone, R. J., Burgess, K., Cogdell, R. J. , Beatson, S. A., Vollmer, W., Smith, D. G.E. and Roe, A. (2015) The host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9, pp. 1039-1051. (doi: 10.1038/ismej.2014.242) (PMID:25526369) (PMCID:PMC4366372)

2014

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi: 10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

This list was generated on Thu Dec 9 07:56:33 2021 GMT.
Jump to: Articles
Number of items: 24.

Articles

Connolly, J. P.R., Turner, N. C.A., Hallam, J., Rimbi, P. T., Flett, T., McCormack, M. J., Roe, A. J. and O'Boyle, N. (2021) D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes. Microbiology, 167(10), 001093. (doi: 10.1099/mic.0.001093) (PMID:34623236)

Connolly, J. P.R., Roe, A. J. and O'Boyle, N. (2021) Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria. Critical Reviews in Microbiology, 47(1), pp. 126-140. (doi: 10.1080/1040841X.2020.1854172) (PMID:33332206)

O'Boyle, N., Connolly, J. P.R., Tucker, N. P. and Roe, A. J. (2020) Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 117(36), pp. 22484-22493. (doi: 10.1073/pnas.2004977117) (PMID:32848072) (PMCID:PMC7486766)

Connolly, J. P.R., O'Boyle, N. and Roe, A. J. (2020) Widespread strain-specific distinctions in chromosomal binding dynamics of a highly conserved Escherichia coli transcription factor. mBio, 11, e01058-20. (doi: 10.1128/mBio.01058-20) (PMID:32576674) (PMCID:PMC7315121)

O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)

Fox, S., Goswami, C. , Holden, M., Connolly, J. P.R., Mordue, J., O'Boyle, N., Roe, A. , Connor, M., Leanord, A. and Evans, T. J. (2020) A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage. Scientific Reports, 10, 4135. (doi: 10.1038/s41598-020-61026-x) (PMID:32139768) (PMCID:PMC7058095)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

Connolly, J. P.R., O'Boyle, N., Turner, N., Browning, D. F. and Roe, A. J. (2019) Distinct intra-species virulence mechanisms regulated by a conserved transcription factor. Proceedings of the National Academy of Sciences of the United States of America, 116(39), pp. 19695-19704. (doi: 10.1073/pnas.1903461116) (PMID:31501343) (PMCID:PMC6765310)

Irvine, S., Bunk, B., Bayes, H. K., Spröer, C., Connolly, J. P.R., Six, A., Evans, T. J. , Roe, A. J. , Overmann, J. and Walker, D. (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)

McHugh, R. E., O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

Scott, N. A. et al. (2018) Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Science Translational Medicine, 10(464), eaao4755. (doi: 10.1126/scitranslmed.aao4755) (PMID:30355800) (PMCID:PMC6548564)

Blum, S. E. et al. (2018) Postgenomics characterization of an essential genetic determinant of mammary pathogenic Escherichia coli. mBio, 9(2), e00423-18. (doi: 10.1128/mBio.00423-18) (PMID:29615502) (PMCID:PMC5885034)

O'Boyle, N., Connolly, J. P.R. and Roe, A. J. (2018) Tracking elusive cargo: Illuminating spatio-temporal type 3 effector protein dynamics using reporters. Cellular Microbiology, 20(1), e12797. (doi: 10.1111/cmi.12797) (PMID:29087624) (PMCID:PMC5765406)

Connolly, J. P.R. et al. (2018) Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nature Communications, 9, 4187. (doi: 10.1038/s41467-018-06701-4) (PMID:30305622) (PMCID:PMC6180029)

Zambelloni, R., Connolly, J. P.R., Huerta Uribe, A., Burgess, K., Marquez, R. and Roe, A. J. (2017) Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition. Molecular Microbiology, 105(4), pp. 606-619. (doi: 10.1111/mmi.13719) (PMID:28557017) (PMCID:PMC5575525)

Connolly, J. P.R. and Roe, A. J. (2016) Intracellular D-serine accumulation promotes genetic diversity via modulated induction of RecA in enterohemorrhagic Escherichia coli. Journal of Bacteriology, 198(24), pp. 3318-3328. (doi: 10.1128/JB.00548-16) (PMID:27698085) (PMCID:PMC5116935)

Huerta-Uribe, A. et al. (2016) Identification and characterization of novel compounds blocking Shiga toxin expression in Escherichia coli O157:H7. Frontiers in Microbiology, 7, 1930. (doi: 10.3389/fmicb.2016.01930) (PMID:27965652) (PMCID:PMC5127787)

Palevsky, N., Shemer, B., Connolly, J. and Belkin, S. (2016) The highly conserved Escherichia coli transcription factor YhaJ regulates aromatic compound degradation. Frontiers in Microbiology, 7, 1490. (doi: 10.3389/fmicb.2016.01490) (PMID:27713734) (PMCID:PMC5031710)

Connolly, J. P.R. and Roe, A. J. (2016) When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment. Microbial Cell, 3(4), pp. 181-184. (doi: 10.15698/mic2016.04.494) (PMID:28357351) (PMCID:PMC5349093)

Connolly, J. P. R., Gabrielsen, M. , Goldstone, R. J., Grinter, R., Wang, D., Cogdell, R. J. , Walker, D. , Smith, D. G. E. and Roe, A. J. (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

Connolly, J.P., Finlay, B.B. and Roe, A.J. (2015) From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli. Frontiers in Microbiology, 6, 568. (doi: 10.3389/fmicb.2015.00568) (PMID:26097473) (PMCID:PMC4456613)

Connolly, J. P.R., Goldstone, R. J., Burgess, K., Cogdell, R. J. , Beatson, S. A., Vollmer, W., Smith, D. G.E. and Roe, A. (2015) The host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9, pp. 1039-1051. (doi: 10.1038/ismej.2014.242) (PMID:25526369) (PMCID:PMC4366372)

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi: 10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

This list was generated on Thu Dec 9 07:56:33 2021 GMT.