2022

Alenezi, S. S. et al. (2022) The antiprotozoal activity of Papua New Guinea propolis and its triterpenes. Molecules, 27(5), 1622. (doi: 10.3390/molecules27051622) (PMID:35268726) (PMCID:PMC8911803)

Cisneros, D. et al. (2022) Imidazoline- and benzamidine-based trypanosome alternative oxidase inhibitors: synthesis and structure–activity relationship studies. ACS Medicinal Chemistry Letters, 13(2), pp. 312-318. (doi: 10.1021/acsmedchemlett.1c00717) (PMID:35178188) (PMCID:PMC8842630)

2021

Cueto-Díaz, E. J. et al. (2021) Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the Trypanosome Alternative Oxidase. European Journal of Medicinal Chemistry, 2020, 113470. (doi: 10.1016/j.ejmech.2021.113470) (PMID:33940464)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Alotaibi, A. et al. (2021) Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana. Molecules, 26(13), 3912. (doi: 10.3390/molecules26133912) (PMID:34206940) (PMCID:PMC8272135)

2020

Ungogo, M. A., Ebiloma, G. U., Ichoron, N., Igoli, J. O., De Koning, H. P. and Balogun, E. O. (2020) A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora. Frontiers in Chemistry, 8, 617448. (doi: 10.3389/fchem.2020.617448) (PMID:33425860) (PMCID:PMC7786139)

2019

Akazue, P. I., Ebiloma, G. U., Ajibola, O., Isaac, C., Onyekwelu, K., Ezeh, C. O. and Eze, A. A. (2019) Sustainable elimination (zero cases) of sleeping sickness: how far are we from achieving this goal? Pathogens, 8(3), e135. (doi: 10.3390/pathogens8030135) (PMID:31470522)

Ebiloma, G. U., Balogun, E. O., Cueto-Díaz, E. J., de Koning, H. P. and Dardonville, C. (2019) Alternative oxidase inhibitors: mitochondrion-targeting as a strategy for new drugs against pathogenic parasites and fungi. Medicinal Research Reviews, 39(5), pp. 1553-1602. (doi: 10.1002/med.21560) (PMID:30693533)

Cerone, M. et al. (2019) Discovery of sustainable drugs for neglected tropical diseases: cashew nut shell liquid (CNSL)-based hybrids target mitochondrial function and ATP production in Trypanosoma brucei. ChemMedChem, 14(6), pp. 621-635. (doi: 10.1002/cmdc.201800790) (PMID:30664325) (PMCID:PMC6686156)

Siheri, W. et al. (2019) Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis. Molecules, 24(6), 1041. (doi: 10.3390/molecules24061041) (PMID:30884752)

Nnadi, C., Ebiloma, G. U., Black, J. A., Nwodo, N., Lemgruber, L. , Schmidt, T. J. and De Koning, H. P. (2019) Potent antitrypanosomal activities of 3-aminosteroids against African trypanosomes: investigation of cellular effects and of cross-resistance with existing drugs. Molecules, 24(2), 268. (doi: 10.3390/molecules24020268) (PMID:30642032)

2018

Meco-Navas, A. et al. (2018) SAR of 4-alkoxybenzoic acid inhibitors of the trypanosome alternative oxidase. ACS Medicinal Chemistry Letters, 9(9), pp. 923-928. (doi: 10.1021/acsmedchemlett.8b00282) (PMID:30258542)

Ebiloma, G. U. et al. (2018) Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. European Journal of Medicinal Chemistry, 150, pp. 385-402. (doi: 10.1016/j.ejmech.2018.02.075) (PMID:29544150)

Ebiloma, G. U., Katsoulis, E., Igoli, J. O., Gray, A. I. and De Koning, H. P. (2018) Multi-target mode of action of a clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes. Scientific Reports, 8, 4613. (doi: 10.1038/s41598-018-22908-3) (PMID:29545637) (PMCID:PMC5854603)

2017

Ebiloma, G. U., Igoli, J. O., Katsoulis, E., Donachie, A.-M., Eze, A., Gray, A. I. and de Koning, H. P. (2017) Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals. Journal of Ethnopharmacology, 202, pp. 256-264. (doi: 10.1016/j.jep.2017.03.028) (PMID:28336470)

Articles

Alenezi, S. S. et al. (2022) The antiprotozoal activity of Papua New Guinea propolis and its triterpenes. Molecules, 27(5), 1622. (doi: 10.3390/molecules27051622) (PMID:35268726) (PMCID:PMC8911803)

Cisneros, D. et al. (2022) Imidazoline- and benzamidine-based trypanosome alternative oxidase inhibitors: synthesis and structure–activity relationship studies. ACS Medicinal Chemistry Letters, 13(2), pp. 312-318. (doi: 10.1021/acsmedchemlett.1c00717) (PMID:35178188) (PMCID:PMC8842630)

Cueto-Díaz, E. J. et al. (2021) Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the Trypanosome Alternative Oxidase. European Journal of Medicinal Chemistry, 2020, 113470. (doi: 10.1016/j.ejmech.2021.113470) (PMID:33940464)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Alotaibi, A. et al. (2021) Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana. Molecules, 26(13), 3912. (doi: 10.3390/molecules26133912) (PMID:34206940) (PMCID:PMC8272135)

Ungogo, M. A., Ebiloma, G. U., Ichoron, N., Igoli, J. O., De Koning, H. P. and Balogun, E. O. (2020) A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora. Frontiers in Chemistry, 8, 617448. (doi: 10.3389/fchem.2020.617448) (PMID:33425860) (PMCID:PMC7786139)

Akazue, P. I., Ebiloma, G. U., Ajibola, O., Isaac, C., Onyekwelu, K., Ezeh, C. O. and Eze, A. A. (2019) Sustainable elimination (zero cases) of sleeping sickness: how far are we from achieving this goal? Pathogens, 8(3), e135. (doi: 10.3390/pathogens8030135) (PMID:31470522)

Ebiloma, G. U., Balogun, E. O., Cueto-Díaz, E. J., de Koning, H. P. and Dardonville, C. (2019) Alternative oxidase inhibitors: mitochondrion-targeting as a strategy for new drugs against pathogenic parasites and fungi. Medicinal Research Reviews, 39(5), pp. 1553-1602. (doi: 10.1002/med.21560) (PMID:30693533)

Cerone, M. et al. (2019) Discovery of sustainable drugs for neglected tropical diseases: cashew nut shell liquid (CNSL)-based hybrids target mitochondrial function and ATP production in Trypanosoma brucei. ChemMedChem, 14(6), pp. 621-635. (doi: 10.1002/cmdc.201800790) (PMID:30664325) (PMCID:PMC6686156)

Siheri, W. et al. (2019) Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis. Molecules, 24(6), 1041. (doi: 10.3390/molecules24061041) (PMID:30884752)

Nnadi, C., Ebiloma, G. U., Black, J. A., Nwodo, N., Lemgruber, L. , Schmidt, T. J. and De Koning, H. P. (2019) Potent antitrypanosomal activities of 3-aminosteroids against African trypanosomes: investigation of cellular effects and of cross-resistance with existing drugs. Molecules, 24(2), 268. (doi: 10.3390/molecules24020268) (PMID:30642032)

Meco-Navas, A. et al. (2018) SAR of 4-alkoxybenzoic acid inhibitors of the trypanosome alternative oxidase. ACS Medicinal Chemistry Letters, 9(9), pp. 923-928. (doi: 10.1021/acsmedchemlett.8b00282) (PMID:30258542)

Ebiloma, G. U. et al. (2018) Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. European Journal of Medicinal Chemistry, 150, pp. 385-402. (doi: 10.1016/j.ejmech.2018.02.075) (PMID:29544150)

Ebiloma, G. U., Katsoulis, E., Igoli, J. O., Gray, A. I. and De Koning, H. P. (2018) Multi-target mode of action of a clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes. Scientific Reports, 8, 4613. (doi: 10.1038/s41598-018-22908-3) (PMID:29545637) (PMCID:PMC5854603)

Ebiloma, G. U., Igoli, J. O., Katsoulis, E., Donachie, A.-M., Eze, A., Gray, A. I. and de Koning, H. P. (2017) Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals. Journal of Ethnopharmacology, 202, pp. 256-264. (doi: 10.1016/j.jep.2017.03.028) (PMID:28336470)