Dr Jacqueline Howie
- Affiliate (Institute of Cardiovascular & Medical Sciences)
Publications
2021
Boguslavskyi, A. et al. (2021) Phospholemman phosphorylation regulates vascular tone, blood pressure and hypertension in mice and man. Circulation, 143(11), pp. 1123-1138. (doi: 10.1161/CIRCULATIONAHA.119.040557) (PMID:33334125) (PMCID:PMC7969167)
2020
Plain, F., Howie, J., Kennedy, J., Brown, E., Shattock, M. J., Fraser, N. J. and Fuller, W. (2020) Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. Communications Biology, 3, 411. (doi: 10.1038/s42003-020-01145-3) (PMID:32737405) (PMCID:PMC7395175)
Gök, C. , Plain, F., Robertson, A., Howie, J., Baillie, G. S. , Fraser, N. J. and Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31(10), 107697. (doi: 10.1016/j.celrep.2020.107697) (PMID:32521252) (PMCID:PMC7296346)
Fraser, N. J., Howie, J., Wypijewski, K. J. and Fuller, W. (2020) Therapeutic targeting of protein S-acylation for the treatment of disease. Biochemical Society Transactions, 48(1), pp. 281-290. (doi: 10.1042/BST20190707) (PMID:31872231)
2018
Howie, J., Wypijewski, K. J., Plain, F., Tulloch, L. B., Fraser, N. J. and Fuller, W. (2018) Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation. Critical Reviews in Biochemistry and Molecular Biology, 53(2), pp. 175-191. (doi: 10.1080/10409238.2018.1432560) (PMID:29424237)
2014
Howie, J. et al. (2014) Substrate recognition by the cell surface palmitoyl transferase DHHC5. Proceedings of the National Academy of Sciences of the United States of America, 111(49), pp. 17534-17539. (doi: 10.1073/pnas.1413627111) (PMID:25422474) (PMCID:PMC4267385)
2013
Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi: 10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)
Fuller, W. , Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J. and Wypijewski, K.J. (2013) Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), pp. 1357-1380. (doi: 10.1007/s00018-012-1134-y) (PMID:22955490) (PMCID:PMC3607738)
Howie, J., Tulloch, L. B., Shattock, M. J. and Fuller, W. (2013) Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochemical Society Transactions, 41(1), pp. 95-100. (doi: 10.1042/BST20120269) (PMID:23356265)
2011
El-Armouche, A., Wittköpper, K., Fuller, W. , Howie, J., Shattock, M. J. and Pavlovic, D. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB Journal, 25(12), pp. 4467-4475. (doi: 10.1096/fj.11-184903) (PMID:21849407)
Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi: 10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)
2009
Fuller, W. , Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. and Shattock, M. J. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. American Journal of Physiology: Cell Physiology, 296(6), C1346-C1355. (doi: 10.1152/ajpcell.00523.2008) (PMID:19339511) (PMCID:PMC2692419)
Articles
Boguslavskyi, A. et al. (2021) Phospholemman phosphorylation regulates vascular tone, blood pressure and hypertension in mice and man. Circulation, 143(11), pp. 1123-1138. (doi: 10.1161/CIRCULATIONAHA.119.040557) (PMID:33334125) (PMCID:PMC7969167)
Plain, F., Howie, J., Kennedy, J., Brown, E., Shattock, M. J., Fraser, N. J. and Fuller, W. (2020) Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. Communications Biology, 3, 411. (doi: 10.1038/s42003-020-01145-3) (PMID:32737405) (PMCID:PMC7395175)
Gök, C. , Plain, F., Robertson, A., Howie, J., Baillie, G. S. , Fraser, N. J. and Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31(10), 107697. (doi: 10.1016/j.celrep.2020.107697) (PMID:32521252) (PMCID:PMC7296346)
Fraser, N. J., Howie, J., Wypijewski, K. J. and Fuller, W. (2020) Therapeutic targeting of protein S-acylation for the treatment of disease. Biochemical Society Transactions, 48(1), pp. 281-290. (doi: 10.1042/BST20190707) (PMID:31872231)
Howie, J., Wypijewski, K. J., Plain, F., Tulloch, L. B., Fraser, N. J. and Fuller, W. (2018) Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation. Critical Reviews in Biochemistry and Molecular Biology, 53(2), pp. 175-191. (doi: 10.1080/10409238.2018.1432560) (PMID:29424237)
Howie, J. et al. (2014) Substrate recognition by the cell surface palmitoyl transferase DHHC5. Proceedings of the National Academy of Sciences of the United States of America, 111(49), pp. 17534-17539. (doi: 10.1073/pnas.1413627111) (PMID:25422474) (PMCID:PMC4267385)
Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi: 10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)
Fuller, W. , Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J. and Wypijewski, K.J. (2013) Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), pp. 1357-1380. (doi: 10.1007/s00018-012-1134-y) (PMID:22955490) (PMCID:PMC3607738)
Howie, J., Tulloch, L. B., Shattock, M. J. and Fuller, W. (2013) Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochemical Society Transactions, 41(1), pp. 95-100. (doi: 10.1042/BST20120269) (PMID:23356265)
El-Armouche, A., Wittköpper, K., Fuller, W. , Howie, J., Shattock, M. J. and Pavlovic, D. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB Journal, 25(12), pp. 4467-4475. (doi: 10.1096/fj.11-184903) (PMID:21849407)
Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi: 10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)
Fuller, W. , Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. and Shattock, M. J. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. American Journal of Physiology: Cell Physiology, 296(6), C1346-C1355. (doi: 10.1152/ajpcell.00523.2008) (PMID:19339511) (PMCID:PMC2692419)