2024

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210) (PMID:37936324) (Early Online Publication)

2023

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Koessinger, D. et al. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5(1), vdad067. (doi: 10.1093/noajnl/vdad067) (PMID:37334166) (PMCID:PMC10276538)

2022

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29(10), pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3) (PMID:35473984) (PMCID:PMC9525582)

Närvä, E. et al. (2022) MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience, 25(6), 104459. (doi: 10.1016/j.isci.2022.104459) (PMID:35677646) (PMCID:PMC9167974)

2021

Rabas, N. et al. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220(12), e202006049. (doi: 10.1083/jcb.202006049) (PMID:34623384) (PMCID:PMC8641410)

Marco, S. et al. (2021) Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nature Communications, 12, 6829. (doi: 10.1038/s41467-021-26839-y) (PMID:34819513) (PMCID:PMC8613289)

Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)

2020

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N. , Chalmers, A. J. , Norman, J. C. and Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, 15361. (doi: 10.1038/s41598-020-72322-x) (PMID:32958777) (PMCID:PMC7506024)

Taskinen, M. E. et al. (2020) MASTL promotes cell contractility and motility through kinase-independent signaling. Journal of Cell Biology, 219(6), e20190620. (doi: 10.1083/jcb.201906204) (PMID:32311005) (PMCID:PMC7265322)

2019

Juin, A. et al. (2019) N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis. Developmental Cell, 51(4), 431-445.e7. (doi: 10.1016/j.devcel.2019.09.018) (PMID:31668663) (PMCID:PMC6863394)

Auciello, F. R. et al. (2019) A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery, 9(5), pp. 617-627. (doi: 10.1158/2159-8290.CD-18-1212) (PMID:30837243) (PMCID:PMC6497553)

Linnane, E., Davey, P., Zhang, P., Puri, S., Edbrooke, M., Chiarparin, E., Revenko, A. S., Macleod, A. R., Norman, J. C. and Ross, S. J. (2019) Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines. Nucleic Acids Research, 47(9), pp. 4375-4392. (doi: 10.1093/nar/gkz214) (PMID:30927008) (PMCID:PMC6511877)

2018

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

2017

Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8, 2255. (doi: 10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)

Dornier, E. G. and Norman, J. C. (2017) Tensin links energy metabolism to extracellular matrix assembly. Journal of Cell Biology, 216(4), pp. 867-869. (doi: 10.1083/jcb.201702025) (PMID:28325807)

Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi: 10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I. , Edwards, J. , Zanivan, S. and Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130(4), pp. 697-711. (doi: 10.1242/jcs.190835) (PMID:28062852)

Norman, J. and Zanivan, S. (2017) Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), pp. 1993-1994. (doi: 10.1080/15384101.2017.1377031) (PMID:28933594)

2016

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Boulay, P.-L. et al. (2016) Rab11-FIP1C Is a critical negative regulator in ErbB2-mediated mammary tumor progression. Cancer Research, 76(9), pp. 2662-2674. (doi: 10.1158/0008-5472.CAN-15-2782) (PMID:26933086)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

2015

Rainero, E. and Norman, J. C. (2015) Endosomal integrin signals for survival. Nature Cell Biology, 17(11), pp. 1373-1375. (doi: 10.1038/ncb3261) (PMID:26515017)

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B. , Anderson, K., Critchley, D. R., Machesky, L. and Norman, J. C. (2015) Ligand-occupied integrin internalization links nutrient signaling to invasive migration. Cell Reports, 10(3), pp. 398-413. (doi: 10.1016/j.celrep.2014.12.037)

2014

MacPherson, I. R. et al. (2014) CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. Journal of Cell Science, 127(18), pp. 3893-3901. (doi: 10.1242/jcs.135947) (PMID:25015290)

Haugsten, E. M., Brech, A., Liestøl, K., Norman, J. C. and Wesche, J. (2014) Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling. Traffic, 15(6), pp. 665-683. (doi: 10.1111/tra.12168)

Muller, P. A.J., Trinidad, A. G., Caswell, P. T., Norman, J. C. and Vousden, K. H. (2014) Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. Journal of Biological Chemistry, 289(1), pp. 122-132. (doi: 10.1074/jbc.M113.502138)

Macagno, J. P., Diaz Vera, J., Yu, Y., MacPherson, I. , Sandilands, E., Palmer, R., Norman, J. C. , Frame, M. and Vidal, M. (2014) FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genetics, 10(3), e1004262. (doi: 10.1371/journal.pgen.1004262)

Rainero, E. et al. (2014) The diacylglycerol kinase α/Atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness. PLoS ONE, 9(6), e97144. (doi: 10.1371/journal.pone.0097144) (PMID:24887021) (PMCID:PMC4041662)

2013

Jacquemet, G., Green, D.M., Bridgewater, R.E., von Kriegsheim, A., Humphries, M.J., Norman, J.C. and Caswell, P.T. (2013) RCP-driven 5 1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. Journal of Cell Biology, 202(6), pp. 917-935. (doi: 10.1083/jcb.201302041)

Rainero, E. and Norman, J.C. (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. BioEssays, 35(6), pp. 523-532. (doi: 10.1002/bies.201200160)

Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi: 10.1038/onc.2012.148)

Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. (2013) P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS ONE, 8(1), e53982. (doi: 10.1371/journal.pone.0053982) (PMID:23382862) (PMCID:PMC3559689)

2012

Rizzolio, S., Rabinowicz, N., Rainero, E., Lanzetti, L., Serini, G., Norman, J. , Neufeld, G. and Tamagnone, L. (2012) Neuropilin-1-dependent regulation of EGF-receptor signaling. Cancer Research, 72(22), pp. 5801-5811. (doi: 10.1158/0008-5472.CAN-12-0995)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi: 10.1083/jcb.201203025)

Christoforides, C., Rainero, E., Brown, K.K., Norman, J.C. and Toker, A. (2012) PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Developmental Cell, 23(3), pp. 560-572. (doi: 10.1016/j.devcel.2012.08.008)

Chen, Y. et al. (2012) Aquaporin 2 promotes cell migration and epithelial morphogenesis. Journal of the American Society of Nephrology, 23(9), pp. 1506-1517. (doi: 10.1681/ASN.2012010079)

Bridgewater, R.E., Norman, J.C. and Caswell, P.T. (2012) Integrin trafficking at a glance. Journal of Cell Science, 125(16), pp. 3695-3701. (doi: 10.1242/jcs.095810)

Eva, R., Crisp, S., Marland, J.R.K., Norman, J.C. , Kanamarlapudi, V., ffrench-Constant, C. and Fawcett, J.W. (2012) ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons. Journal of Neuroscience, 32(30), pp. 10352-10364.

von Thun, A., Birtwistle, M., Kalna, G., Grindlay, J., Strachan, D., Kolch, W., von Kriegsheim, A. and Norman, J.C. (2012) ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. Journal of Cell Science, 125(6), pp. 1465-1477. (doi: 10.1242/jcs.092916)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi: 10.1016/j.devcel.2011.11.008)

Margadant, C., Kreft, M., de Groot, D., Norman, J.C. and Sonnenberg, A. (2012) Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking. Current Biology, 22(17), pp. 1554-1563. (doi: 10.1016/j.cub.2012.06.060)

Rainero, E., Caswell, P.T., Muller, P.A.J., Grindlay, J., McCaffrey, M.W., Zhang, Q., Wakelam, M.J.O., Vousden, K.H., Graziani, A. and Norman, J.C. (2012) Diacylglycerol kinase controls RCP-dependent integrin trafficking to promote invasive migration. Journal of Cell Biology, 196(2), pp. 277-295. (doi: 10.1083/jcb.201109112)

2011

Margadant, C., Monsuur, H.N., Norman, J.C. and Sonnenberg, A. (2011) Mechanisms of integrin activation and trafficking. Current Opinion in Cell Biology, 23(5), pp. 607-614. (doi: 10.1016/j.ceb.2011.08.005)

Muller, P.A.J., Vousden, K. and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192(2), pp. 209-218. (doi: 10.1083/jcb.201009059)

Rainero, E. and Norman, J.C. (2011) New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing. Science Signaling, 4(171), pe24. (doi: 10.1126/scisignal.2002053)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H. , Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi: 10.1242/jcs.080986)

2010

Di Blasio, L., Droetto, S., Norman, J. , Bussolino, F. and Primo, L. (2010) Protein Kinase D1 Regulates VEGF-A-Induced αvβ3 Integrin Trafficking and Endothelial Cell Migration. Traffic, 11(8), pp. 1107-1118. (doi: 10.1111/j.1600-0854.2010.01077.x)

Eva, R., Dassie, E., Caswell, P.T., Dick, G., ffrench-Constant, C., Norman, J.C. and Fawcett, J.W. (2010) Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of beta 1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells. Journal of Neuroscience, 30(35), pp. 11654-11669. (doi: 10.1523/JNEUROSCI.2425-10.2010)

2009

Caswell, P.T., Vadrevu, S. and Norman, J.C. (2009) Integrins: masters and slaves of endocytic transport. Nature Reviews Molecular Cell Biology, 10(12), pp. 843-853. (doi: 10.1038/nrm2799)

Jones, M.C., Caswell, P.T., Moran-Jones, K., Roberts, M., Barry, S.T., Gampel, A., Mellor, H. and Norman, J.C. (2009) VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching. Traffic, 10(6), pp. 754-766. (doi: 10.1111/j.1600-0854.2009.00898.x)

Kelly, E.E., Horgan, C.P., Adams, C., Patzer, T.M., Ní Shúilleabháin, D.M., Norman, J.C. and McCaffrey, M.W. (2009) Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. Biology of the Cell, 102(1), pp. 51-62. (doi: 10.1042/BC20090068)

Mills, G.B., Jurisica, I., Yarden, Y. and Norman, J.C. (2009) Genomic amplicons target vesicle recycling in breast cancer. Journal of Clinical Investigation, 119(8), pp. 2123-2127. (doi: 10.1172/JCI40256)

Moran-Jones, K., Grindlay, J., Jones, M., Smith, R. and Norman, J.C. (2009) hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration. Cancer Research, 69(24), pp. 9219-9227. (doi: 10.1158/0008-5472.CAN-09-1852)

Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi: 10.1016/j.cell.2009.11.026)

Reynolds, A.R. et al. (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15(4), pp. 392-400. (doi: 10.1038/nm.1941)

Valdembri, D. et al. (2009) Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells. PLoS Biology, 7(1), e1000025. (doi: 10.1371/journal.pbio.1000025)

2008

Caswell, P. and Norman, J. (2008) Endocytic transport of integrins during cell migration and invasion. Trends in Cell Biology, 18(6), pp. 257-263. (doi: 10.1016/j.tcb.2008.03.004)

Caswell, P.T., Chan, M., Lindsay, A.J., McCaffrey, M.W., Boettiger, D. and Norman, J.C. (2008) Rab-coupling protein coordinates recycling of  5 1 integrin and EGFR1 to promote cell migration in 3D microenvironments. Journal of Cell Biology, 183(1), pp. 143-155. (doi: 10.1083/jcb.200804140)

Frame, M. and Norman, J. (2008) A tal(in) of cell spreading. Nature Cell Biology, 10(9), pp. 1017-1019. (doi: 10.1038/ncb0908-1017)

2007

Caswell, P. et al. (2007) Rab25 associates with alpha 5 beta 1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell, 13(4), pp. 496-510. (doi: 10.1016/j.devcel.2007.08.012)

Kim, M. et al. (2007) Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis, 29(3), pp. 629-637. (doi: 10.1093/carcin/bgm291)

Muddasani, P., Norman, J. , Ellman, M., van Wijnen, A. and Im, H. (2007) Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. Journal of Biological Chemistry, 282(43), pp. 31409-31421. (doi: 10.1074/jbc.M706508200)

White, D., Caswell, P. and Norman, J. (2007) alpha V beta 3 and alpha 5B1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. Journal of Cell Biology, 177(3), pp. 515-525. (doi: 10.1083/jcb.200609004)

2006

Caswell, P. and Norman, J. (2006) Integrin trafficking and the control of cell migration. Traffic, 7, pp. 14-21. (doi: 10.1111/j.1600-0854.2005.00362.x)

Gampel, A., Moss, L., Jones, M., Brunton, V., Norman, J. and Mellor, H. (2006) VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood, 108, pp. 2624-2631. (doi: 10.1182/blood-2005-12-007484)

Jones, M., Caswell, T. and Norman, J. (2006) Endocytic recycling pathways: emerging regulators of cell migration. Current Opinion in Cell Biology, 18(5), pp. 549-557. (doi: 10.1016/j.ceb.2006.08.003)

2004

Sandilands, E., Cans, C., Fincham, V., Brunton, V., Mellor, H., Prendergast, G., Norman, J. , Superti-Furga, G. and Frame, M. (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Developmental Cell, 7(6), pp. 855-869. (doi: 10.1016/j.devcel.2004.09.019)

Articles

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210) (PMID:37936324) (Early Online Publication)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Koessinger, D. et al. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5(1), vdad067. (doi: 10.1093/noajnl/vdad067) (PMID:37334166) (PMCID:PMC10276538)

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29(10), pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3) (PMID:35473984) (PMCID:PMC9525582)

Närvä, E. et al. (2022) MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience, 25(6), 104459. (doi: 10.1016/j.isci.2022.104459) (PMID:35677646) (PMCID:PMC9167974)

Rabas, N. et al. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220(12), e202006049. (doi: 10.1083/jcb.202006049) (PMID:34623384) (PMCID:PMC8641410)

Marco, S. et al. (2021) Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nature Communications, 12, 6829. (doi: 10.1038/s41467-021-26839-y) (PMID:34819513) (PMCID:PMC8613289)

Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N. , Chalmers, A. J. , Norman, J. C. and Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, 15361. (doi: 10.1038/s41598-020-72322-x) (PMID:32958777) (PMCID:PMC7506024)

Taskinen, M. E. et al. (2020) MASTL promotes cell contractility and motility through kinase-independent signaling. Journal of Cell Biology, 219(6), e20190620. (doi: 10.1083/jcb.201906204) (PMID:32311005) (PMCID:PMC7265322)

Juin, A. et al. (2019) N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis. Developmental Cell, 51(4), 431-445.e7. (doi: 10.1016/j.devcel.2019.09.018) (PMID:31668663) (PMCID:PMC6863394)

Auciello, F. R. et al. (2019) A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery, 9(5), pp. 617-627. (doi: 10.1158/2159-8290.CD-18-1212) (PMID:30837243) (PMCID:PMC6497553)

Linnane, E., Davey, P., Zhang, P., Puri, S., Edbrooke, M., Chiarparin, E., Revenko, A. S., Macleod, A. R., Norman, J. C. and Ross, S. J. (2019) Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines. Nucleic Acids Research, 47(9), pp. 4375-4392. (doi: 10.1093/nar/gkz214) (PMID:30927008) (PMCID:PMC6511877)

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8, 2255. (doi: 10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)

Dornier, E. G. and Norman, J. C. (2017) Tensin links energy metabolism to extracellular matrix assembly. Journal of Cell Biology, 216(4), pp. 867-869. (doi: 10.1083/jcb.201702025) (PMID:28325807)

Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi: 10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I. , Edwards, J. , Zanivan, S. and Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130(4), pp. 697-711. (doi: 10.1242/jcs.190835) (PMID:28062852)

Norman, J. and Zanivan, S. (2017) Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), pp. 1993-1994. (doi: 10.1080/15384101.2017.1377031) (PMID:28933594)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Boulay, P.-L. et al. (2016) Rab11-FIP1C Is a critical negative regulator in ErbB2-mediated mammary tumor progression. Cancer Research, 76(9), pp. 2662-2674. (doi: 10.1158/0008-5472.CAN-15-2782) (PMID:26933086)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

Rainero, E. and Norman, J. C. (2015) Endosomal integrin signals for survival. Nature Cell Biology, 17(11), pp. 1373-1375. (doi: 10.1038/ncb3261) (PMID:26515017)

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B. , Anderson, K., Critchley, D. R., Machesky, L. and Norman, J. C. (2015) Ligand-occupied integrin internalization links nutrient signaling to invasive migration. Cell Reports, 10(3), pp. 398-413. (doi: 10.1016/j.celrep.2014.12.037)

MacPherson, I. R. et al. (2014) CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. Journal of Cell Science, 127(18), pp. 3893-3901. (doi: 10.1242/jcs.135947) (PMID:25015290)

Haugsten, E. M., Brech, A., Liestøl, K., Norman, J. C. and Wesche, J. (2014) Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling. Traffic, 15(6), pp. 665-683. (doi: 10.1111/tra.12168)

Muller, P. A.J., Trinidad, A. G., Caswell, P. T., Norman, J. C. and Vousden, K. H. (2014) Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. Journal of Biological Chemistry, 289(1), pp. 122-132. (doi: 10.1074/jbc.M113.502138)

Macagno, J. P., Diaz Vera, J., Yu, Y., MacPherson, I. , Sandilands, E., Palmer, R., Norman, J. C. , Frame, M. and Vidal, M. (2014) FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genetics, 10(3), e1004262. (doi: 10.1371/journal.pgen.1004262)

Rainero, E. et al. (2014) The diacylglycerol kinase α/Atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness. PLoS ONE, 9(6), e97144. (doi: 10.1371/journal.pone.0097144) (PMID:24887021) (PMCID:PMC4041662)

Jacquemet, G., Green, D.M., Bridgewater, R.E., von Kriegsheim, A., Humphries, M.J., Norman, J.C. and Caswell, P.T. (2013) RCP-driven 5 1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. Journal of Cell Biology, 202(6), pp. 917-935. (doi: 10.1083/jcb.201302041)

Rainero, E. and Norman, J.C. (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. BioEssays, 35(6), pp. 523-532. (doi: 10.1002/bies.201200160)

Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi: 10.1038/onc.2012.148)

Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. (2013) P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS ONE, 8(1), e53982. (doi: 10.1371/journal.pone.0053982) (PMID:23382862) (PMCID:PMC3559689)

Rizzolio, S., Rabinowicz, N., Rainero, E., Lanzetti, L., Serini, G., Norman, J. , Neufeld, G. and Tamagnone, L. (2012) Neuropilin-1-dependent regulation of EGF-receptor signaling. Cancer Research, 72(22), pp. 5801-5811. (doi: 10.1158/0008-5472.CAN-12-0995)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi: 10.1083/jcb.201203025)

Christoforides, C., Rainero, E., Brown, K.K., Norman, J.C. and Toker, A. (2012) PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Developmental Cell, 23(3), pp. 560-572. (doi: 10.1016/j.devcel.2012.08.008)

Chen, Y. et al. (2012) Aquaporin 2 promotes cell migration and epithelial morphogenesis. Journal of the American Society of Nephrology, 23(9), pp. 1506-1517. (doi: 10.1681/ASN.2012010079)

Bridgewater, R.E., Norman, J.C. and Caswell, P.T. (2012) Integrin trafficking at a glance. Journal of Cell Science, 125(16), pp. 3695-3701. (doi: 10.1242/jcs.095810)

Eva, R., Crisp, S., Marland, J.R.K., Norman, J.C. , Kanamarlapudi, V., ffrench-Constant, C. and Fawcett, J.W. (2012) ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons. Journal of Neuroscience, 32(30), pp. 10352-10364.

von Thun, A., Birtwistle, M., Kalna, G., Grindlay, J., Strachan, D., Kolch, W., von Kriegsheim, A. and Norman, J.C. (2012) ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. Journal of Cell Science, 125(6), pp. 1465-1477. (doi: 10.1242/jcs.092916)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi: 10.1016/j.devcel.2011.11.008)

Margadant, C., Kreft, M., de Groot, D., Norman, J.C. and Sonnenberg, A. (2012) Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking. Current Biology, 22(17), pp. 1554-1563. (doi: 10.1016/j.cub.2012.06.060)

Rainero, E., Caswell, P.T., Muller, P.A.J., Grindlay, J., McCaffrey, M.W., Zhang, Q., Wakelam, M.J.O., Vousden, K.H., Graziani, A. and Norman, J.C. (2012) Diacylglycerol kinase controls RCP-dependent integrin trafficking to promote invasive migration. Journal of Cell Biology, 196(2), pp. 277-295. (doi: 10.1083/jcb.201109112)

Margadant, C., Monsuur, H.N., Norman, J.C. and Sonnenberg, A. (2011) Mechanisms of integrin activation and trafficking. Current Opinion in Cell Biology, 23(5), pp. 607-614. (doi: 10.1016/j.ceb.2011.08.005)

Muller, P.A.J., Vousden, K. and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192(2), pp. 209-218. (doi: 10.1083/jcb.201009059)

Rainero, E. and Norman, J.C. (2011) New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing. Science Signaling, 4(171), pe24. (doi: 10.1126/scisignal.2002053)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H. , Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi: 10.1242/jcs.080986)

Di Blasio, L., Droetto, S., Norman, J. , Bussolino, F. and Primo, L. (2010) Protein Kinase D1 Regulates VEGF-A-Induced αvβ3 Integrin Trafficking and Endothelial Cell Migration. Traffic, 11(8), pp. 1107-1118. (doi: 10.1111/j.1600-0854.2010.01077.x)

Eva, R., Dassie, E., Caswell, P.T., Dick, G., ffrench-Constant, C., Norman, J.C. and Fawcett, J.W. (2010) Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of beta 1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells. Journal of Neuroscience, 30(35), pp. 11654-11669. (doi: 10.1523/JNEUROSCI.2425-10.2010)

Caswell, P.T., Vadrevu, S. and Norman, J.C. (2009) Integrins: masters and slaves of endocytic transport. Nature Reviews Molecular Cell Biology, 10(12), pp. 843-853. (doi: 10.1038/nrm2799)

Jones, M.C., Caswell, P.T., Moran-Jones, K., Roberts, M., Barry, S.T., Gampel, A., Mellor, H. and Norman, J.C. (2009) VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching. Traffic, 10(6), pp. 754-766. (doi: 10.1111/j.1600-0854.2009.00898.x)

Kelly, E.E., Horgan, C.P., Adams, C., Patzer, T.M., Ní Shúilleabháin, D.M., Norman, J.C. and McCaffrey, M.W. (2009) Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. Biology of the Cell, 102(1), pp. 51-62. (doi: 10.1042/BC20090068)

Mills, G.B., Jurisica, I., Yarden, Y. and Norman, J.C. (2009) Genomic amplicons target vesicle recycling in breast cancer. Journal of Clinical Investigation, 119(8), pp. 2123-2127. (doi: 10.1172/JCI40256)

Moran-Jones, K., Grindlay, J., Jones, M., Smith, R. and Norman, J.C. (2009) hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration. Cancer Research, 69(24), pp. 9219-9227. (doi: 10.1158/0008-5472.CAN-09-1852)

Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi: 10.1016/j.cell.2009.11.026)

Reynolds, A.R. et al. (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15(4), pp. 392-400. (doi: 10.1038/nm.1941)

Valdembri, D. et al. (2009) Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells. PLoS Biology, 7(1), e1000025. (doi: 10.1371/journal.pbio.1000025)

Caswell, P. and Norman, J. (2008) Endocytic transport of integrins during cell migration and invasion. Trends in Cell Biology, 18(6), pp. 257-263. (doi: 10.1016/j.tcb.2008.03.004)

Caswell, P.T., Chan, M., Lindsay, A.J., McCaffrey, M.W., Boettiger, D. and Norman, J.C. (2008) Rab-coupling protein coordinates recycling of  5 1 integrin and EGFR1 to promote cell migration in 3D microenvironments. Journal of Cell Biology, 183(1), pp. 143-155. (doi: 10.1083/jcb.200804140)

Frame, M. and Norman, J. (2008) A tal(in) of cell spreading. Nature Cell Biology, 10(9), pp. 1017-1019. (doi: 10.1038/ncb0908-1017)

Caswell, P. et al. (2007) Rab25 associates with alpha 5 beta 1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell, 13(4), pp. 496-510. (doi: 10.1016/j.devcel.2007.08.012)

Kim, M. et al. (2007) Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis, 29(3), pp. 629-637. (doi: 10.1093/carcin/bgm291)

Muddasani, P., Norman, J. , Ellman, M., van Wijnen, A. and Im, H. (2007) Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. Journal of Biological Chemistry, 282(43), pp. 31409-31421. (doi: 10.1074/jbc.M706508200)

White, D., Caswell, P. and Norman, J. (2007) alpha V beta 3 and alpha 5B1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. Journal of Cell Biology, 177(3), pp. 515-525. (doi: 10.1083/jcb.200609004)

Caswell, P. and Norman, J. (2006) Integrin trafficking and the control of cell migration. Traffic, 7, pp. 14-21. (doi: 10.1111/j.1600-0854.2005.00362.x)

Gampel, A., Moss, L., Jones, M., Brunton, V., Norman, J. and Mellor, H. (2006) VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood, 108, pp. 2624-2631. (doi: 10.1182/blood-2005-12-007484)

Jones, M., Caswell, T. and Norman, J. (2006) Endocytic recycling pathways: emerging regulators of cell migration. Current Opinion in Cell Biology, 18(5), pp. 549-557. (doi: 10.1016/j.ceb.2006.08.003)

Sandilands, E., Cans, C., Fincham, V., Brunton, V., Mellor, H., Prendergast, G., Norman, J. , Superti-Furga, G. and Frame, M. (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Developmental Cell, 7(6), pp. 855-869. (doi: 10.1016/j.devcel.2004.09.019)