Professor Richard Hartley

Professor of Chemical Biology (School of Chemistry)

telephone: 01413304398
email: Richard.Hartley@glasgow.ac.uk

C403c C-wing Level 4, Joseph Black Building, University of Glasgow, Glasgow, G12 8qq

Research interests

Research Interests

Professor Richard Hartley is a chemical biologist. The Hartley group uses synthetic organic chemistry to unlock the secrets of biology and treat disease. He is an expert in the chemistry that occurs in mitochondria and in redox signalling. His group is the chemical core of multidisiciplinary teams tackling the biggest problems in medicine. Professor Hartley has helped to pin down the cause of reperfusion injury in stroke, transplant and heart attack; to explain why resting metabolic rates vary naturally; to test the free radical theory of aging; and to explain how inflammation is switched off by the mitochondrial metabolite, itaconate. Profesor Hartley was the originator of the ‘Protection Hypothesis’ in behavioural ecology. The impact of his work is clear. Molecular probes developed in his lab are now marketed worldwide by Cayman Chemical and by other companies. These include MitoB and MitoParaquat. A spin out company, Antoxis, arose from his research.

Research Topics

Chemical Biology
Medicinal Chemistry
Synthesis
Mitochondria
Molecular Probes
Reactive oxygen species (ROS)
Prodrugs and Photoactivatable compounds
Redox signalling

Publication Metrics

Publons:ResearcherID E-3489-2010

Publication Highlights

Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo.Cell Chemical Biology, 26(3), 449-461.e8. (doi:10.1016/j.chembiol.2018.12.002)(PMID:30713096)(PMCID:PMC6436940)
Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.Nature, 5556, pp. 113-117. (doi:10.1038/nature25986)(PMID:29590092)
Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.Free Radical Biology and Medicine, 89, pp. 883-894. (doi:10.1016/j.freeradbiomed.2015.08.021)(PMID:26454075)
Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Nature, 515(7527), pp. 431-435. (doi:10.1038/nature13909)(PMID:25383517)(PMCID:PMC4255242)
Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G.and Hartley, R. C.(2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.Journal of the American Chemical Society, 134(2), pp. 758-761. (doi:10.1021/ja2077922)(PMID:22239373)(PMCID:PMC3260739)
Cochemé, H.M. et al. (2011) Measurement of H₂O₂within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.Cell Metabolism, 13(3), pp. 340-350. (doi:10.1016/j.cmet.2011.02.003)(PMID:21356523)(PMCID:PMC4413513)

Most of the Hartley research group members

Research groups

Chemical Biology & Precision Synthesis

Publications

Selected publications

All publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000

Number of items: 96.

2024

Cardwell, P. A., Del Moro, C., Murphy, M. P., Lapthorn, A. J. and Hartley, R. C. (2024) Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates. Bioorganic and Medicinal Chemistry, (doi: 10.1016/j.bmc.2024.117712) (In Press)

2023

Uno, S., Harkiss, A. H., Chowdhury, R., Caldwell, S. T. , Prime, T. A., James, A. M., Gallagher, B., Prudent, J., Hartley, R. C. and Murphy, M. P. (2023) Incorporating a polyethyleneglycol linker to enhance the hydrophilicity of mitochondria‐targeted triphenylphosphonium constructs. ChemBioChem, 24(11), e202200774. (doi: 10.1002/cbic.202200774) (PMID:36917207)

2022

Miljkovic, J. L. et al. (2022) Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biology, 55, 102429. (doi: 10.1016/j.redox.2022.102429) (PMID:35961099) (PMCID:PMC9382561)

James, A. M., Norman, A. A. I., Houghton, J. W., Prag, H. A., Logan, A., Antrobus, R., Hartley, R. C. and Murphy, M. P. (2022) Native chemical ligation approach to sensitively probe tissue acyl-CoA pools. Cell Chemical Biology, 29(7), 1232-1244.e5. (doi: 10.1016/j.chembiol.2022.04.005) (PMID:35868236) (PMCID:PMC9586882)

Burger, N. et al. (2022) ND3 Cys39 in complex I is exposed during mitochondrial respiration. Cell Chemical Biology, 29(4), 636-649.e14. (doi: 10.1016/j.chembiol.2021.10.010) (PMID:34739852)

Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

Ryan, D. G. et al. (2022) Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response. iScience, 25(2), 103827. (doi: 10.1016/j.isci.2022.103827)

Prag, H. A. et al. (2022) Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo. Cardiovascular Drugs and Therapy, 36(1), pp. 1-13. (doi: 10.1007/s10557-020-07033-6) (PMID:32648168) (PMCID:PMC8770414)

2021

Carter, R. N. et al. (2021) The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Reports, 37(6), 109958. (doi: 10.1016/j.celrep.2021.109958) (PMID:34758301) (PMCID:PMC8595646)

Cairns, A. G., McQuaker, S. J., Murphy, M. P. and Hartley, R. C. (2021) Insights on targeting small molecules to the mitochondrial matrix and the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide. In: Weissig, V. and Edeas, M. (eds.) Mitochondrial Medicine: Volume 1: Targeting Mitochondria. Series: Methods in molecular biology (2275). Humana: New York, NY, pp. 87-117. ISBN 9781071612613 (doi: 10.1007/978-1-0716-1262-0_6)

Caldwell, S. T. , O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57(32), pp. 3917-3920. (doi: 10.1039/D0CC07713E) (PMID:33871501) (PMCID:PMC7611313)

Gaddale Devanna, K. K. et al. (2021) Tetra-arylborate lipophilic anions as targeting groups. Chemical Communications, 57(25), pp. 3147-3150. (doi: 10.1039/D0CC07924C) (PMID:33634803) (PMCID:PMC8062962)

Cvetko, F., Caldwell, S. T. , Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C. , Dinkova-Kostova, A. and Murphy, M. P. (2021) Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry, 296, 100169. (doi: 10.1074/jbc.RA120.016551) (PMID:33298526) (PMCID:PMC7948991)

Tan, S. M. et al. (2021) Targeting methylglyoxal in diabetic kidney disease using the mitochondria-targeted compound MitoGamide. Nutrients, 13(5), 1457. (doi: 10.3390/nu13051457) (PMID:33922959) (PMCID:PMC8145135)

2020

Park, M. et al. (2020) Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart. Cardiovascular Drugs and Therapy, 34, pp. 823-834. (doi: 10.1007/s10557-020-07086-7) (PMID:32979176)

Aggarwal, V. K. et al. (2020) Stuart Warren (24 Dec 1938–22 Mar 2020). Organic and Biomolecular Chemistry, 18(37), pp. 7236-7237. (doi: 10.1039/D0OB90121K) (PMID:32936190)

Pala, L., Senn, H. M. , Caldwell, S. T. , Prime, T. A., Warrington, S., Bright, T. P., Prag, H. A., Wilson, C. , Murphy, M. and Hartley, R. C. (2020) Enhancing the mitochondrial uptake of phosphonium cations by carboxylic acid incorporation. Frontiers in Chemistry, 8, 783. (doi: 10.3389/fchem.2020.00783)

Prag, H. A., Kula-Alwar, D., Pala, L., Caldwell, S. T. , Beach, T. E., James, A. M., Saeb-Parsy, K., Krieg, T., Hartley, R. C. and Murphy, M. P. (2020) Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker. Molecular Pharmaceutics, 17(9), pp. 3526-3540. (doi: 10.1021/acs.molpharmaceut.0c00533) (PMID:32692564) (PMCID:PMC7482397)

Beach, T. E. et al. (2020) Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury. Redox Biology, 36, 101640. (doi: 10.1016/j.redox.2020.101640)

Chowdhury, A. R., Zielonka, J., Kalyanaraman, B., Hartley, R. C. , Murphy, M. P. and Avadhani, N. G. (2020) Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: a dose-dependent phenomenon. Redox Biology, 36, 101606. (doi: 10.1016/j.redox.2020.101606)

Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. T. , Krieg, T., Hartley, R. C. , James, A. M. and Murphy, M. P. (2020) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radical Biology and Medicine, 147, pp. 37-47. (doi: 10.1016/j.freeradbiomed.2019.11.028) (PMID:31811922) (PMCID:PMC6975167)

2019

Tate, M. et al. (2019) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide, is cardioprotective in the diabetic heart. Cardiovascular Drugs and Therapy, 33(6), pp. 669-674. (doi: 10.1007/s10557-019-06914-9) (PMID:31654171) (PMCID:PMC6994445)

Martin, J. et al. (2019) Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)

Lim, P. J. et al. (2019) Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature Metabolism, 1, pp. 519-531. (doi: 10.1038/s42255-019-0063-6) (PMID:31276102)

Antonucci, S. et al. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 134, pp. 678-687. (doi: 10.1016/j.freeradbiomed.2019.01.034) (PMID:30731114)

Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo. Cell Chemical Biology, 26(3), 449-461.e8. (doi: 10.1016/j.chembiol.2018.12.002) (PMID:30713096) (PMCID:PMC6436940)

Pinho, B. R., Reis, S. D., Hartley, R. C. , Murphy, M. P. and Oliveira, J. M.A. (2019) Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radical Biology and Medicine, 130, pp. 318-327. (doi: 10.1016/j.freeradbiomed.2018.10.446) (PMID:30389496) (PMCID:PMC6340810)

Lau, G. Y., Barts, N., Hartley, R. C. , Tobler, M., Richards, J. G., Murphy, M. P. and Arndt, S. (2019) Detection of changes in mitochondrial hydrogen sulfide (H2S) in vivo in the fish model Poecilia mexicana (Poeciliidae). Biology Open, 8, bio041467. (doi: 10.1242/bio.041467) (PMID:31072908) (PMCID:PMC6550084)

2018

Murphy, M. P. and Hartley, R. C. (2018) Mitochondria as a therapeutic target for common pathologies. Nature Reviews Drug Discovery, 17, pp. 865-886. (doi: 10.1038/nrd.2018.174) (PMID:30393373)

Salin, K., Villasevil, E. M., Anderson, G. J., Auer, S. K., Selman, C. , Hartley, R. C. , Mullen, W. , Chinopoulos, C. and Metcalfe, N. B. (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32(9), pp. 2149-2157. (doi: 10.1111/1365-2435.13125) (PMID:30333678) (PMCID:PMC6175143)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Guthrie, S., Jensen, T., Hartley, R. C. , Ramaesh, K. and Lockington, D. (2018) Assessing the accuracy of intracameral phenylephrine preparation in cataract surgery. Eye, 32, pp. 1615-1620. (doi: 10.1038/s41433-018-0143-y) (PMID:29907787)

Fazakerley, D. J. et al. (2018) Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)

Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 5556, pp. 113-117. (doi: 10.1038/nature25986) (PMID:29590092) (PMCID:PMC6047741)

Cao, Z., Mitchell, L., Hsia, O., Scarpa, M., Caldwell, S. T. , Alfred, A. D., Gennaris, A., Collet, J.-F., Hartley, R. C. and Bulleid, N. J. (2018) Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase. Biochemical Journal, 475, pp. 827-838. (doi: 10.1042/BCJ20170929) (PMID:29420254) (PMCID:PMC6488974)

2017

Shchepinova, M. M. et al. (2017) MitoNeoD: a mitochondria-targeted superoxide probe. Cell Chemical Biology, 24(10), 1285-1298.e12. (doi: 10.1016/j.chembiol.2017.08.003) (PMID:28890317) (PMCID:PMC6278870)

Pawellek, A., Ryder, U., Tammsalu, T., King, L. J., Kreinin, H., Ly, T., Hay, R. T., Hartley, R. and Lamond, A. I. (2017) Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. eLife, 6, e27402. (doi: 10.7554/eLife.27402) (PMID:28884683)

Arndt, S. et al. (2017) Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. Journal of Biological Chemistry, 292(19), pp. 7761-7773. (doi: 10.1074/jbc.M117.784678) (PMID:28320864) (PMCID:PMC5427258)

Salin, K., Auer, S. K., Villasevil, E. M., Anderson, G. J., Cairns, A. G., Mullen, W. , Hartley, R. C. and Metcalfe, N. B. (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)

2016

Buskiewicz, I. A. et al. (2016) Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus. Science Signaling, 9(456), ra115. (doi: 10.1126/scisignal.aaf1933) (PMID:27899525)

McGarry, D. J., Shchepinova, M. M., Lillla, S., Hartley, R. C. and Olson, M. F. (2016) A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids. ACS Chemical Biology, 11(12), pp. 3300-3304. (doi: 10.1021/acschembio.6b00742) (PMID:27792307)

2015

Caldwell, S. T. , Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W. , McCarron, J. G. and Hartley, R. C. (2015) Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)

Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi: 10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)

Salin, K., Auer, S. k., Rudolf, A. M., Anderson, G. J., Cairns, A. G., Mullen, W. , Hartley, R. C. , Selman, C. and Metcalfe, N. B. (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi: 10.1098/rsbl.2015.0538) (PMID:26382073)

Cairns, A. G., McQuaker, S. J., Murphy, M. P. and Hartley, R. C. (2015) Targeting mitochondria with small molecules: the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide. In: Weissig, V. and Edeas, M. (eds.) Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function. Series: Methods in Molecular Biology, 1265. Springer New York, pp. 25-50. ISBN 9781493922871 (doi: 10.1007/978-1-4939-2288-8_3)

2014

Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi: 10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)

Logan, A., Shabalina, I. G., Prime, T. A., Rogatti, S., Kalinovich, A. V., Hartley, R. C. , Budd, R. C., Cannon, B. and Murphy, M. P. (2014) In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell, 13(4), pp. 765-768. (doi: 10.1111/acel.12212) (PMID:24621297) (PMCID:PMC4326952)

Cairns, A. G., Senn, H. M. , Murphy, M. P. and Hartley, R. C. (2014) Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi: 10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)

Li Pun, P. B. et al. (2014) A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radical Biology and Medicine, 67, pp. 437-450. (doi: 10.1016/j.freeradbiomed.2013.11.025) (PMID:24316194) (PMCID:PMC3978666)

Logan, A. et al. (2014) Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), pp. 923-930. (doi: 10.1016/j.bbagen.2013.05.026) (PMID:23726990)

2013

McQuaker, S. J., Quinlan, C. L., Caldwell, S. T. , Brand, M. D. and Hartley, R. C. (2013) A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)

Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)

Sikora, A., Zielonka, J., Adamus, J., Debski, D., Dybala-Defratyka, A., Michalowski, B., Joseph, J., Hartley, R.C. , Murphy, M.P. and Kalyanaraman, B. (2013) Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. Chemical Research in Toxicology, 26(6), pp. 856-867. (doi: 10.1021/tx300499c) (PMID:23611338) (PMCID:PMC3700382)

2012

Harvey, A. L., Young, L. C., Kornisiuk, E., Snitcofsky, M., Colettis, N., Blanco, C., Jerusalinsky, D., Jamieson, A. G. , Hartley, R. C. and Stone, T. W. (2012) A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234(2), pp. 184-191. (doi: 10.1016/j.bbr.2012.06.023)

Smith, R.A.J., Hartley, R.C. , Cochemé, H.M. and Murphy, M.P. (2012) Mitochondrial pharmacology. Trends in Pharmacological Sciences, 33(6), pp. 341-352. (doi: 10.1016/j.tips.2012.03.010) (PMID:22521106)

Cochemé, H.M. et al. (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H₂O₂ in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi: 10.1038/nprot.2012.035) (PMID:22517261)

Caldwell, S.T. , McPhail, D.B., Duthie, G.D. and Hartley, R.C. (2012) Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)

Chalmers, S., Caldwell, S. T. , Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)

Omar, M.H., Mullen, W. , Stalmach, A. , Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-¹⁴C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)

2011

Smith, R. A.J., Hartley, R. C. and Murphy, M. P. (2011) Mitochondria-targeted small molecule therapeutics and probes. Antioxidants and Redox Signaling, 15(12), pp. 3021-3038. (doi: 10.1089/ars.2011.3969) (PMID:21395490)

Figlus, M., Wellaway, N., Cooper, A.W.J., Sollis, S.L. and Hartley, R.C. (2011) Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction. ACS Combinatorial Science, 13(3), pp. 280-285. (doi: 10.1021/co100091n)

Cochemé, H.M. et al. (2011) Measurement of H₂O₂ within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi: 10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)

Haahr, A., Rankovic, Z. and Hartley, R. (2011) A one-pot procedure for methylenating carbonyl compounds using the Nysted reagent and titanocene dichloride. Tetrahedron Letters, 52(23), pp. 3020-3022. (doi: 10.1016/j.tetlet.2011.04.017)

2010

Quin, C., Robertson, L., McQuaker, S.J., Price, N.C., Brand, M.D. and Hartley, R.C. (2010) Caged mitochondrial uncouplers that are released in response to hydrogen peroxide. Tetrahedron, 66(13), pp. 2384-2389. (doi: 10.1016/j.tet.2010.01.103) (PMID:20418941) (PMCID:PMC2852674)

Figlus, M., Tarruella, A.C., Messer, A., Sollis, S.L. and Hartley, R.C. (2010) Low molecular weight MPEG-assisted organic synthesis. Chemical Communications, 46(24), pp. 4405-4407. (doi: 10.1039/c0cc00415d)

2009

Quin, C., Trnka, J., Hay, A., Murphy, M.P. and Hartley, R.C. (2009) Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization. Tetrahedron, 65(39), pp. 8154-8160. (doi: 10.1016/j.tet.2009.07.081) (PMID:19888470) (PMCID:PMC2767131)

Robertson, L. and Hartley, R. C. (2009) Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants. Tetrahedron, 65(27), pp. 5284-5292. (doi: 10.1016/j.tet.2009.04.083) (PMID:19693262) (PMCID:PMC2722452)

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G. and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi: 10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

2008

Main, C.A., Rahman, S.S. and Hartley, R.C. (2008) Synthesis of spiroacetals using functionalised titanium carbenoids. Tetrahedron Letters, 49(32), pp. 4771-4774. (doi: 10.1016/j.tetlet.2008.05.094)

Main, C.A., Petersson, H.M., Rahman, S.S. and Hartley, R.C. (2008) High throughput synthesis of 2,5-substituted indoles using a titanium carbenoid bearing boronate functionality. Tetrahedron, 64(5), pp. 901-914. (doi: 10.1016/j.tet.2007.08.119)

Mullen, W. , Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)

2007

Caldwell, S. T., Quin, C., Edge, R. and Hartley, R. C. (2007) A dual sensor spin trap for use with EPR spectroscopy. Organic Letters, 9(18), pp. 3499-3502. (doi: 10.1021/ol071285o)

Adriaenssens, L. V. and Hartley, R. C. (2007) beta-amino acids to piperidinones by petasis methylenation and acid-induced cyclization. Journal of Organic Chemistry, 72(26), pp. 10287-10290. (doi: 10.1021/jo7019948)

Austin, C., Smith, D. and Hartley, R. (2007) Solid-phase synthesis of cyclic imines - potential for radiolabelling. Journal of Labelled Compounds and Radiopharmaceuticals, 50, pp. 502-503. (doi: 10.1002/jlcr.1224)

Farrugia, L., Hartley, R. , Calver, A. and Rahman, S. (2007) 5-Bromoanthranil. Acta Crystallographica. Section E: Structure Reports Online, 63, O2540-O2541. (doi: 10.1107/S1600536807017278)

Hartley, R. , Li, J., Main, C. and McKiernan, G. (2007) Titanium carbenoid reagents for converting carbonyl groups into alkenes. Tetrahedron, 63, pp. 4825-4864. (doi: 10.1016/j.tet.2007.03.015)

2006

Adriaenssens, L., Austin, C., Gibson, M., Smith, D. and Hartley, R. (2006) Stereodivergent diversity oriented synthesis of piperidine alkaloids. European Journal of Organic Chemistry, pp. 4998-5001. (doi: 10.1002/ejoc.200600744)

Caldwell, S., Petersson, H., Farrugia, L., Mullen, W., Crozier, A. and Hartley, R. (2006) Isotopic labelling of quercetin 3-glucoside. Tetrahedron, 62, pp. 7257-7265. (doi: 10.1016/j.tet.2006.05.046)

Sklavounou, E., Hay, A., Ashraf, N., Lamb, K., Brown, E., Mac Intyre, A., George, W.D., Hartley, R.C. and Shiels, P.G. (2006) The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi: 10.1016/j.bbrc.2006.06.087)

2005

Graf, B., Mullen, W., Caldwell, S., Hartley, R., Duthie, G., Lean, M., Crozier, A. and Edwards, C. (2005) Disposition and metabolism of [2-C-14]quercetin-4 '-glucoside in rats. Drug Metabolism and Disposition, 33, pp. 1036-1043. (doi: 10.1124/dmd.104.002691)

Hay, A., Burkitt, M., Jones, C. and Hartley, R. (2005) Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy) benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes. Archives of Biochemistry and Biophysics, 435, pp. 336-346. (doi: 10.1016/j.abb.2004.12.030)

2004

Bennett, C., Caldwell, S., McPhail, D., Morrice, P., Duthie, G. and Hartley, R. (2004) Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorganic and Medicinal Chemistry, 12, pp. 2079-2098. (doi: 10.1016/j.bmc.2004.02.031)

Macleod, C., Austin, C., Hamprecht, D. and Hartley, R. (2004) Preparation of quinolines from resin-bound esters using titanium reagents. Tetrahedron Letters, 45, pp. 8879-8882. (doi: 10.1016/j.tetlet.2004.09.170)

Roberts, C. and Hartley, R. (2004) Titanium reagents for the synthesis of 2-substituted benzo[b]thiophenes on the solid phase. Journal of Organic Chemistry, 69, pp. 6145-6148. (doi: 10.1021/jo049344o)

Woodland, C., Crawley, G. and Hartley, R. (2004) Stereoselectivity in the anionic oxy-Cope rearrangement of acyclic vinyl sulfides. Tetrahedron Letters, 45, pp. 1227-1231. (doi: 10.1016/j.tetlet.2003.11.132)

2003

Gibson, M., Goodman, J., Farrugia, L. and Hartley, R. (2003) Controlling neighbouring group participation from thioacetals. Tetrahedron Letters, 44, pp. 2841-2844. (doi: 10.1016/S0040-4039(03)00440-4)

Macleod, C., McKiernan, G., Guthrie, E., Farrugia, L., Hamprecht, D., Macritchie, J. and Hartley, R. (2003) Synthesis of 2-substituted benzofurans and Indoles using functionalized titanium benzylidene reagents on solid phase. Journal of Organic Chemistry, 68, pp. 387-401. (doi: 10.1021/jo026384o)

McKiernan, G. and Hartley, R. (2003) Boronate titanium alkylidene reagents for diversity-based synthesis of benzofurans. Organic Letters, 5, pp. 4389-4392. (doi: 10.1021/ol035677g)

McPhail, D., Hartley, R. , Gardner, P. and Duthie, G. (2003) Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. Journal of Agricultural and Food Chemistry, 51, pp. 1684-1690. (doi: 10.1021/jf025922v)

Mullen, W., Hartley, R. and Crozier, A. (2003) Detection and identification of C-14-labelled flavonol metabolites by high-performance liquid chromatography-radiocounting and tandem mass spectrometry. Journal of Chromatography A, 1007, pp. 21-29. (doi: 10.1016/S0021-9673(03)00882-3)

2002

Hartley, R.C. and McKiernan, G.J. (2002) Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives. Journal of the Chemical Society: Perkin Transactions 1, pp. 2763-2793. (doi: 10.1039/b009709h)

Macleod, C., Hartley, R.C. and Hamprecht, D.W. (2002) Novel functionalized titanium(IV) benzylidenes for the traceless solid-phase synthesis of indoles. Organic Letters, 4, pp. 75-78. (doi: 10.1021/ol016924o)

Mullen, W., Graf, B., Caldwell, S., Hartley, R., Duthie, G., Edwards, C., Lean, M. and Crozier, A. (2002) Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-C-14]quercetin-4' glucoside. Journal of Agricultural and Food Chemistry, 50, pp. 6902-6909. (doi: 10.1021/jf020598p)

2001

Rutherford, A.P., Gibb, C.S., Hartley, R.C. and Goodman, J.M. (2001) Stereocontrol in a one-pot procedure for anionic oxy-Cope rearrangement followed by intramolecular aldol reaction. Journal of the Chemical Society: Perkin Transactions 1, pp. 1051-1061. (doi: 10.1039/b010138i)

2000

Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)

Hartley, R. C. and Caldwell, S. T. (2000) Novel methods for the synthesis of three-, four-, five-, six- and seven-membered, saturated and partially unsaturated carbocycles. Journal of the Chemical Society: Perkin Transactions 1, 1(4), pp. 477-501. (doi: 10.1039/A804421J)

This list was generated on Wed Apr 24 08:21:01 2024 BST.

Jump to: Articles | Book Sections

Number of items: 96.

Articles

Burger, N. et al. (2022) ND3 Cys39 in complex I is exposed during mitochondrial respiration. Cell Chemical Biology, 29(4), 636-649.e14. (doi: 10.1016/j.chembiol.2021.10.010) (PMID:34739852)

Ryan, D. G. et al. (2022) Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response. iScience, 25(2), 103827. (doi: 10.1016/j.isci.2022.103827)

Aggarwal, V. K. et al. (2020) Stuart Warren (24 Dec 1938–22 Mar 2020). Organic and Biomolecular Chemistry, 18(37), pp. 7236-7237. (doi: 10.1039/D0OB90121K) (PMID:32936190)

Beach, T. E. et al. (2020) Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury. Redox Biology, 36, 101640. (doi: 10.1016/j.redox.2020.101640)

Martin, J. et al. (2019) Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)

Murphy, M. P. and Hartley, R. C. (2018) Mitochondria as a therapeutic target for common pathologies. Nature Reviews Drug Discovery, 17, pp. 865-886. (doi: 10.1038/nrd.2018.174) (PMID:30393373)

Main, C.A., Rahman, S.S. and Hartley, R.C. (2008) Synthesis of spiroacetals using functionalised titanium carbenoids. Tetrahedron Letters, 49(32), pp. 4771-4774. (doi: 10.1016/j.tetlet.2008.05.094)

Caldwell, S. T., Quin, C., Edge, R. and Hartley, R. C. (2007) A dual sensor spin trap for use with EPR spectroscopy. Organic Letters, 9(18), pp. 3499-3502. (doi: 10.1021/ol071285o)

Farrugia, L., Hartley, R. , Calver, A. and Rahman, S. (2007) 5-Bromoanthranil. Acta Crystallographica. Section E: Structure Reports Online, 63, O2540-O2541. (doi: 10.1107/S1600536807017278)

Hartley, R. , Li, J., Main, C. and McKiernan, G. (2007) Titanium carbenoid reagents for converting carbonyl groups into alkenes. Tetrahedron, 63, pp. 4825-4864. (doi: 10.1016/j.tet.2007.03.015)

McKiernan, G. and Hartley, R. (2003) Boronate titanium alkylidene reagents for diversity-based synthesis of benzofurans. Organic Letters, 5, pp. 4389-4392. (doi: 10.1021/ol035677g)

Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)

Book Sections

This list was generated on Wed Apr 24 08:21:01 2024 BST.

Supervision

28 phds have graduated from my group. 26 of these have continued in science or research-related careers.

Teaching

Level-3 Mechanistic Organic Chemistry
Level-4 Chemical Biology

Professional activities & recognition

Editorial boards

Journal of the Royal Society Interface

Professional & learned societies

Fellow, Royal Society of Chemistry
Fellow, Royal Society of Biology
Chemistry Biology Interface Division Council Member, Royal Society of Chemistry
Member, American Chemical Society
Investigator, Wellcome Trust
External Examiner of Undergraduate Degrees (Chemistry), University of Aberdeen
College Member, EPSRC

Research datasets

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018

Number of items: 10.

2024

Cardwell, P. A., Del Moro, C., Murphy, M. P., Lapthorn, A. J. and Hartley, R. C. (2024) Human mitochondrial glutathione transferases: kinetic parameters and accommodation of a mitochondria-targeting group in substrates. [Data Collection]

2023

Uno, S., Harkiss, A., Chowdhury, R., Caldwell, S. , Prime, T. A., James, A. M., Gallagher, B., Prudent, J., Hartley, R. and Murphy, M. (2023) Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. [Data Collection]

2022

Miljkovic, J. L., Burger, N., Gawel, J. M., Mulvey, J. F., Norman, A. A. I., Nishimura, T., Tsujihata, Y., Logan, A., Sauchanka, O., Caldwell, S. , Morris, J. L., Prudent, J., Prime, T. A., Warrington, S., Bates, G. R., Aksentijević, D., Prag, H., James, A. M., Krieg, T., Hartley, R. and Murphy, M. (2022) Rapid and Selective Generation of H2S within Mitochondria Protects Against Cardiac Ischemia-Reperfusion Injury. [Data Collection]

2021

James, A. M., Norman, A., Houghton, J. W., Prag, H. A., Logan, A., Antrobus, R., Hartley, R. and Murphy, M. (2021) Native-chemical-ligation approach to sensitively probe tissue acyl-CoA pools. [Data Collection]

2020

Pala, L., Senn, H. , Caldwell, S. , Prime, T. A., Warrington, S., Bright, T. P., Prag, H., Wilson, C. , Murphy, M. and Hartley, R. (2020) Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation. [Data Collection]

Prag, H. A., Kula-Alwar, D., Pala, L., Caldwell, S. , Beach, T., James, A. M., Saeb-Parsy, K., Krieg, T., Hartley, R. and Murphy, M. (2020) Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker. [Data Collection]

2019

Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. , Krieg, T., Hartley, R. , James, A. M. and Murphy, M. P. (2019) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. [Data Collection]

Antonucci, S., Mulvey, J. F., Burger, N., Di Sante, M., Hall, A. R., Hinchy, E. C., Caldwell, S. , Gruszczyk, A. V., Deshwal, S., Hartley, R. , Kaludercic, N., Murphy, M. P., Di Lisa, F. and Kreig, T. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. [Data Collection]

2018

Tate, M., De Blasio, M. J., Prakoso, D., Deo, M., Higgins, G. C., Lindblom, R., Kiriazis, H., Baeza-Garza, C. D., Caldwell, S., Hartley, R. , Krieg, T., Murphy, M. P., Coughlan, M. T. and Ritchie, R. H. (2018) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide is cardioprotective in the diabetic heart. [Data Collection] (Unpublished)

Martin, J. L., Costa, A. S. H., Gruszczyk, A., Beach, T., Allen, F., Prag, H., Hinchy, E. C., Mahbubani, K., Hamed, M., Tronci, L., Nikitopoulou, E., James, A. M., Krieg, T., Robinson, A., Huang, M. H., Caldwell, S. , Logan, A., Pala, L., Hartley, R. , Frezza, C., Saeb-Parsy, K. and Murphy, M. (2018) Succinate accumulation during organ storage drives ischemia-reperfusion injury upon transplantation. [Data Collection]

This list was generated on Wed Apr 24 06:47:24 2024 BST.

Additional information

Researcher ID http://www.researcherid.com/rid/E-3489-2010

Current Grants

Exploring mitochondrial metabolism in health and disease using targeted biological chemistry Wellcome Trust (220257/B/20/Z) £803k (100%)
Mitochondrial ROS mapping and control with sub-organellar resolution BB/T003804/1 £685k (35%). Jan 2020-Dec 2022.

MitoWild ERC €2,445,129 (5%) (2021-2026).
“Why do fish fail at high temperatures?” NERC NE/R001510/1£523,409 (10%). Feb 2018-Jan 2021.

Recent Grants

Exploring mitochondrial metabolism in health and disease using targeted biological chemistry. Wellcome Trust (110158/Z/15/Z) £346,109 (100%). May 2016-Apr 2020.
Thiol Modification and Redox Signalling, MRC Discovery Award. £581,581 (RCH share: £173k). Mar 2016-Apr 2018
The Ecology of Metabolic Phenotypes: From Cells to Populations. ERC £1,701,874 (10%), (Dates: May 2013 – April 2018).

Notable Achievements

Originator of ‘Protection Hypothesis’ in behavioural ecology in seminal paper: Are Carotenoids a Red Herring in Sexual Display.
Spin out company (Antoxis, see http://www.antoxis.com/): I provided its starting research basis by invention of its lead compound, Proxison^TM(WO 2004/007475)
First and currently best probe for quantify hydrogen peroxide in the mitochondria of living organisms (MitoB)

Prof Richard Hartley

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Professor Richard Hartley

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