Professor Jim Anderson
- Professor of Veterinary Neurology and Neurosurgery (Veterinary Science & Education )
telephone:
01413305808
email:
Thomas.Anderson@glasgow.ac.uk
R229 Level 2, Veterinary Biosciences, McCall Building, Glasgow, G61 1QH
https://orcid.org/0000-0003-1266-0906Research interests
My research interests include neuroscience and veterinary clinical research. In the sphere of neuroscience my interests are in the influence of extra copies of the proteolipid protein gene (Plp1) on the process of myelination and in the long term demyleination (which I identified: Journal of Comparative Neurology 1998; 394: 506-519, Glia 2007; 55: 341-51) that occurs in transgenic animals carrying extra copies of this gene. In the clinical sphere my interests include seizure disorders and diseases affecting the neuromuscular system.
Publications
2019
Qi, Y., Montague, P., Loney, C. , Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD 1 protein associated with canine degenerative myelopathy. European Journal of Neuroscience, 50(12), pp. 3896-3905. (doi: 10.1111/ejn.14526) (PMID:31336405)
Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)
2016
Wessmann, A., Volk, H.A., Packer, R.M.A., Ortega, M. and Anderson, T.J. (2016) Quality-of-life aspects in idiopathic epilepsy in dogs. Veterinary Record, 179(9), 229. (doi: 10.1136/vr.103355) (PMID:27329504)
2015
Lin, Y.-W., Volk, H. A., Penderis, J., Anderson, T. J. , Añor, S., Lujan-Feliu-Pascual, A., Stein, V. M., Tipold, A. and Ehlers, J. P. (2015) Development of learning objectives for neurology in a veterinary curriculum: part II: postgraduates. BMC Veterinary Research, 11, 10. (doi: 10.1186/s12917-014-0314-4) (PMID:25622644) (PMCID:PMC4323235)
2014
Shafie, I. N.F., McLaughlin, M. , Burchmore, R. , Lim, M. A. A., Montague, P., Johnston, P. E.J., Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi: 10.1007/s12192-013-0457-4)
Gutierrez Quintana, R. , Penderis, J. and Anderson, T. J. (2014) What is your neurologic diagnosis? Journal of the American Veterinary Medical Association, 244(7), pp. 791-793. (doi: 10.2460/javma.244.7.791) (PMID:24649988)
Wessmann, A., Volk, H.A., Parkin, T. , Ortega, M. and Anderson, T.J. (2014) Evaluation of quality of life in dogs with idiopathic epilepsy. Journal of Veterinary Internal Medicine, 28(2), pp. 510-514. (doi: 10.1111/jvim.12328)
2013
Pickles, K.J., Rhind, S.M., Townsend, J., Anderson, J. , Pearson, G. and Mellanby, R.J. (2013) Similar challenges, different approaches: a review of student support systems in UK veterinary schools. Veterinary Record, 173(4), p. 96. (doi: 10.1136/vr.101314)
Böhm, J. et al. (2013) Altered splicing of the BIN1 muscle-specific exon in humans and dogs with highly progressive centronuclear myopathy. PLoS Genetics, 9(6), e1003430. (doi: 10.1371/journal.pgen.1003430)
Shafie, I.N.F., Anderson, T.J. , Penderis, J., Eckersall, P.D. and McLaughlin, M. (2013) A protocol for the management of canine cerebrospinal fluid for the proteomic assessment of putative biomarkers. Veterinary Journal, 197(3), pp. 836-841. (doi: 10.1016/j.tvjl.2013.05.039)
2012
Gonçalves, R., McBrearty, A., Pratola, L., Calvo, G., Anderson, T.J. and Penderis, J. (2012) Clinical evaluation of cochlear hearing status in dogs using evoked otoacoustic emissions. Journal of Small Animal Practice, 53(6), pp. 344-351. (doi: 10.1111/j.1748-5827.2012.01229.x)
2011
Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)
2010
Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)
Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)
Chang, K.C., McCulloch, M.C. and Anderson, T.J. (2010) Molecular and cellular insights into a distinct myopathy of Great Dane dogs. Veterinary Journal, 183(3), pp. 322-327. (doi: 10.1016/j.tvjl.2008.11.013)
Goncalves, R., Anderson, T.J. , Innocent, G.T. and Penderis, J. (2010) Effect of seizures on cerebrospinal fluid analysis in dogs with idiopathic epilepsy. Veterinary Record, 166(16), pp. 497-498. (doi: 10.1136/vr.b4812)
2009
Lowrie, M., Penderis, J., McLaughlin, M. , Eckersall, P.D. and Anderson, T.J. (2009) Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). Journal of Veterinary Internal Medicine, 23(4), pp. 862-870. (doi: 10.1111/j.1939-1676.2009.0337.x)
Lowrie, M., Penderis, J., Eckersall, P.D., McLaughlin, M. , Mellor, D. and Anderson, T.J. (2009) The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Veterinary Journal, 182(1), pp. 125-130. (doi: 10.1016/j.tvjl.2008.05.001)
Monteiro, R., Anderson, T.J. , Innocent, G., Evans, N.P. and Penderis, J. (2009) Variations in serum concentration of phenobarbitone in dogs receiving regular twice daily doses in relation to the times of administration. Veterinary Record, 165(19), pp. 556-558. (doi: 10.1136/vr.165.19.556)
2008
Goncalves, R., Penderis, J., Chang, Y.P., Zoia, A., Mosley, J. and Anderson, T.J. (2008) Clinical and neurological characteristics of aortic thromboembolism in dogs. Journal of Small Animal Practice, 49(4), pp. 178-184. (doi: 10.1111/j.1748-5827.2007.00530.x)
Gutierrez Quintana, R. , Anderson, T.J. , Innocent, G. and Penderis, J. (2008) The Evolution in Diagnostic Imaging Technique of Choice in Dogs With Thoracolumbar Spinal Cord Injuries and its Influence on Outcome (2000-2007). In: 21st Annual Symposium of the ESVN, Rhodes, Greecxe, 25-27 Sep 2008,
2007
Lowrie, M., Thomson, A. and Anderson, T.J. (2007) Case-report in neurology. Consulta de Diffusion Veterinaria, 15(146), pp. 69-73.
Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)
2006
Cherubini, G.B., Platt, S.R., Anderson, T.J. , Rusbridge, C., Lorenzo, V., Mantis, P. and Cappello, R. (2006) Characteristics of magnetic resonance images of granulomatous meningoencephalomyelitis in 11 dogs. Veterinary Record, 159(4), p. 110. (doi: 10.1136/vr.159.4.110)
Chang, Y., Mellor, D. and Anderson, T.J. (2006) Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. Journal of Small Animal Practice, 47, pp. 574-581.
Feliu-Pascual, A. et al. (2006) Inherited myopathy of great Danes. Journal of Small Animal Practice, 47, pp. 249-254.
2003
Lujan, A., Philbey, A.W. and Anderson, T.J. (2003) Intradural epithelial cyst in a cat. Veterinary Record, 153(12), pp. 363-364. (doi: 10.1136/vr.153.12.363)
Long, S.N., Michieletto, A., Anderson, T.J. , Williams, A. and Knottenbelt, C.M. (2003) Suspected pituitary apoplexy in a German shorthaired pointer - Abstract. Journal of Small Animal Practice, 44, pp. 497-502.
2002
Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi: 10.1083/jcb.200202124)
Long, S., Anderson, T. , Long, F. and Johnston, P. (2002) Evaluation of rapid staining techniques for cytologic diagnosis of intracranial lesions. American Journal of Veterinary Research, 63, pp. 381-386.
Vouyiouklis, D., Anderson, T. , King, H., Kirkham, D., Karim, S., Johnson, K. and Griffiths, I. (2002) Mapping of the dysmyelinating murine hindshaker mutation to a 1.2-cM interval on chromosome 3. Genomics, 80, pp. 126-128. (doi: 10.1006/geno.2002.6811)
2001
Long, S., Johnston, P. and Anderson, T. (2001) Primary T-cell lymphoma of the central nervous system in a dog. Journal of the American Veterinary Medical Association, 218, pp. 719-722.
1998
Griffiths, I. et al. (1998) Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science, 280(5369), pp. 1610-1613. (doi: 10.1126/science.280.5369.1610) (PMID:9616125)
Articles
Qi, Y., Montague, P., Loney, C. , Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD 1 protein associated with canine degenerative myelopathy. European Journal of Neuroscience, 50(12), pp. 3896-3905. (doi: 10.1111/ejn.14526) (PMID:31336405)
Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)
Wessmann, A., Volk, H.A., Packer, R.M.A., Ortega, M. and Anderson, T.J. (2016) Quality-of-life aspects in idiopathic epilepsy in dogs. Veterinary Record, 179(9), 229. (doi: 10.1136/vr.103355) (PMID:27329504)
Lin, Y.-W., Volk, H. A., Penderis, J., Anderson, T. J. , Añor, S., Lujan-Feliu-Pascual, A., Stein, V. M., Tipold, A. and Ehlers, J. P. (2015) Development of learning objectives for neurology in a veterinary curriculum: part II: postgraduates. BMC Veterinary Research, 11, 10. (doi: 10.1186/s12917-014-0314-4) (PMID:25622644) (PMCID:PMC4323235)
Shafie, I. N.F., McLaughlin, M. , Burchmore, R. , Lim, M. A. A., Montague, P., Johnston, P. E.J., Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi: 10.1007/s12192-013-0457-4)
Gutierrez Quintana, R. , Penderis, J. and Anderson, T. J. (2014) What is your neurologic diagnosis? Journal of the American Veterinary Medical Association, 244(7), pp. 791-793. (doi: 10.2460/javma.244.7.791) (PMID:24649988)
Wessmann, A., Volk, H.A., Parkin, T. , Ortega, M. and Anderson, T.J. (2014) Evaluation of quality of life in dogs with idiopathic epilepsy. Journal of Veterinary Internal Medicine, 28(2), pp. 510-514. (doi: 10.1111/jvim.12328)
Pickles, K.J., Rhind, S.M., Townsend, J., Anderson, J. , Pearson, G. and Mellanby, R.J. (2013) Similar challenges, different approaches: a review of student support systems in UK veterinary schools. Veterinary Record, 173(4), p. 96. (doi: 10.1136/vr.101314)
Böhm, J. et al. (2013) Altered splicing of the BIN1 muscle-specific exon in humans and dogs with highly progressive centronuclear myopathy. PLoS Genetics, 9(6), e1003430. (doi: 10.1371/journal.pgen.1003430)
Shafie, I.N.F., Anderson, T.J. , Penderis, J., Eckersall, P.D. and McLaughlin, M. (2013) A protocol for the management of canine cerebrospinal fluid for the proteomic assessment of putative biomarkers. Veterinary Journal, 197(3), pp. 836-841. (doi: 10.1016/j.tvjl.2013.05.039)
Gonçalves, R., McBrearty, A., Pratola, L., Calvo, G., Anderson, T.J. and Penderis, J. (2012) Clinical evaluation of cochlear hearing status in dogs using evoked otoacoustic emissions. Journal of Small Animal Practice, 53(6), pp. 344-351. (doi: 10.1111/j.1748-5827.2012.01229.x)
Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)
Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)
Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)
Chang, K.C., McCulloch, M.C. and Anderson, T.J. (2010) Molecular and cellular insights into a distinct myopathy of Great Dane dogs. Veterinary Journal, 183(3), pp. 322-327. (doi: 10.1016/j.tvjl.2008.11.013)
Goncalves, R., Anderson, T.J. , Innocent, G.T. and Penderis, J. (2010) Effect of seizures on cerebrospinal fluid analysis in dogs with idiopathic epilepsy. Veterinary Record, 166(16), pp. 497-498. (doi: 10.1136/vr.b4812)
Lowrie, M., Penderis, J., McLaughlin, M. , Eckersall, P.D. and Anderson, T.J. (2009) Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). Journal of Veterinary Internal Medicine, 23(4), pp. 862-870. (doi: 10.1111/j.1939-1676.2009.0337.x)
Lowrie, M., Penderis, J., Eckersall, P.D., McLaughlin, M. , Mellor, D. and Anderson, T.J. (2009) The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Veterinary Journal, 182(1), pp. 125-130. (doi: 10.1016/j.tvjl.2008.05.001)
Monteiro, R., Anderson, T.J. , Innocent, G., Evans, N.P. and Penderis, J. (2009) Variations in serum concentration of phenobarbitone in dogs receiving regular twice daily doses in relation to the times of administration. Veterinary Record, 165(19), pp. 556-558. (doi: 10.1136/vr.165.19.556)
Goncalves, R., Penderis, J., Chang, Y.P., Zoia, A., Mosley, J. and Anderson, T.J. (2008) Clinical and neurological characteristics of aortic thromboembolism in dogs. Journal of Small Animal Practice, 49(4), pp. 178-184. (doi: 10.1111/j.1748-5827.2007.00530.x)
Lowrie, M., Thomson, A. and Anderson, T.J. (2007) Case-report in neurology. Consulta de Diffusion Veterinaria, 15(146), pp. 69-73.
Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)
Cherubini, G.B., Platt, S.R., Anderson, T.J. , Rusbridge, C., Lorenzo, V., Mantis, P. and Cappello, R. (2006) Characteristics of magnetic resonance images of granulomatous meningoencephalomyelitis in 11 dogs. Veterinary Record, 159(4), p. 110. (doi: 10.1136/vr.159.4.110)
Chang, Y., Mellor, D. and Anderson, T.J. (2006) Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. Journal of Small Animal Practice, 47, pp. 574-581.
Feliu-Pascual, A. et al. (2006) Inherited myopathy of great Danes. Journal of Small Animal Practice, 47, pp. 249-254.
Lujan, A., Philbey, A.W. and Anderson, T.J. (2003) Intradural epithelial cyst in a cat. Veterinary Record, 153(12), pp. 363-364. (doi: 10.1136/vr.153.12.363)
Long, S.N., Michieletto, A., Anderson, T.J. , Williams, A. and Knottenbelt, C.M. (2003) Suspected pituitary apoplexy in a German shorthaired pointer - Abstract. Journal of Small Animal Practice, 44, pp. 497-502.
Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi: 10.1083/jcb.200202124)
Long, S., Anderson, T. , Long, F. and Johnston, P. (2002) Evaluation of rapid staining techniques for cytologic diagnosis of intracranial lesions. American Journal of Veterinary Research, 63, pp. 381-386.
Vouyiouklis, D., Anderson, T. , King, H., Kirkham, D., Karim, S., Johnson, K. and Griffiths, I. (2002) Mapping of the dysmyelinating murine hindshaker mutation to a 1.2-cM interval on chromosome 3. Genomics, 80, pp. 126-128. (doi: 10.1006/geno.2002.6811)
Long, S., Johnston, P. and Anderson, T. (2001) Primary T-cell lymphoma of the central nervous system in a dog. Journal of the American Veterinary Medical Association, 218, pp. 719-722.
Griffiths, I. et al. (1998) Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science, 280(5369), pp. 1610-1613. (doi: 10.1126/science.280.5369.1610) (PMID:9616125)
Conference Proceedings
Gutierrez Quintana, R. , Anderson, T.J. , Innocent, G. and Penderis, J. (2008) The Evolution in Diagnostic Imaging Technique of Choice in Dogs With Thoracolumbar Spinal Cord Injuries and its Influence on Outcome (2000-2007). In: 21st Annual Symposium of the ESVN, Rhodes, Greecxe, 25-27 Sep 2008,
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Applied Integrated lipidomics and metabolomics to dissect the mechanisms of canine degenerative myelopathy
Wellcome Trust
2021 - 2022
- The identification of toxic pathways associated with canine degenerative myelopathy mutant SOD1 protein: a potential model of fALS
Kuwait Foundation for the Advancement of Sciences
2018 - 2019
- Establishing potential CSF markers of degenerative myelopathy in the dog
Petsavers
2009 - 2010
- An investigation of the role of microglia/macrophages in axonal damage, in the context of demyelination
Multiple Sclerosis Society
2009 - 2011
- Development of an OSCE - Objective structured clinical examination - portal
Higher Education Academy
2007 - 2010
- Proteolipid protein gene dosage and myelination
Biotechnology and Biological Sciences Research Council
2003 - 2006
- Defining the abnormal gene expression profiles of hereditary central core myopathy in the Great Dane - an initial study in elucidating its..
British Small Animal Veterinary Association
2002 - 2007
Supervision
- Black, Lauren
Identification of potential serum biomarkers of canine degenerative myelopathy (CDM) and characterisation of potential pathological mechanisms associated with mutant SOD1 toxicity
Research datasets
2019
Qi, Y., Montague, P., Loney, C., Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD1 protein associated with canine degenerative myelopathy. [Data Collection]
