Professor Keith Muir
- SINAPSE Chair of Clinical Imaging (Centre for Stroke & Brain Imaging)
telephone:
0141 451 5874
email:
Keith.Muir@glasgow.ac.uk
Ground Floor, Office Block, Queen Elizabeth University Hospital, Glasgow G51 4TF
https://orcid.org/0000-0001-9535-022XResearch interests
Major interests are in the treatment of acute stroke and the application of advanced brain imaging techniques to aid treatment decisions in acute stroke; thrombolysis for stroke; clinical trials and clinical trial design in acute stroke; and the inherited syndrome CADASIL (Cerebral Autosomal Dominant Arteripathy with Subcortical Infarction and Leucoencephalopathy).
Research work is predominantly undertaken in the South Glasgow Acute Stroke Service, based in the Institute of Neurological Sciences, where we have established a unit with the highest rates of IV thrombolytic treatment in the UK (and in the top 10 in Europe). Currently, we use a mixture of advanced imaging techniques including CT perfusion and CT angiography, MRI (including novel sequences being developed locally for metabolic imaging) and TCD. The specific techniques depend upon the individual research question – recent work has included the use of MR spectroscopy and DWI lesion volume evolution to investigate the therapeutic effects of insulin treatment for hyperglycaemia in acute stroke, and ongoing studies are investigating the influence of hyperglycaemia on recanalisation and reperfusion rates in acute stroke.
The stroke imaging group includes clinical neuroradiologists, physicists, and neuroscientists, and there is close collaboration between preclinical imaging in rodent models of cerebral ischaemia with the clinical studies.
Publications
2024
MacDonald, A. S. et al. (2024) Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST. Journal of Human Hypertension, (doi: 10.1038/s41371-024-00906-5) (Early Online Publication)
2023
Chalos, V. et al. (2023) Development and validation of a postprocedural model to predict outcome after endovascular treatment for ischemic stroke. JAMA Neurology, 80(9), pp. 940-948. (doi: 10.1001/jamaneurol.2023.2392) (PMID:37523199)
Parry-Jones, A. R., Stocking, K., MacLeod, M. J., Clarke, B., Werring, D. J., Muir, K. W. and Vail, A. (2023) Phase II randomised, placebo-controlled, clinical trial of interleukin-1 receptor antagonist in intracerebral haemorrhage: BLOcking the Cytokine IL-1 in ICH (BLOC-ICH). European Stroke Journal, 8(3), pp. 819-827. (doi: 10.1177/23969873231185208) (PMID:37452707) (PMCID:PMC10472954)
Rex, N. et al. (2023) Endovascular therapy in acute ischemic stroke with poor reperfusion is associated with worse outcomes compared with best medical management: a HERMES substudy. Journal of NeuroInterventional Surgery, -2023. (doi: 10.1136/jnis-2023-020411) (PMID:37532454) (Early Online Publication)
Laskowitz, D. T. et al. (2023) Methodological considerations in PISCES 3: a randomized, placebo-controlled study of intracerebral stem cells in subjects with disability following an ischemic stroke. Frontiers in Stroke, 2, 1182537. (doi: 10.3389/fstro.2023.1182537)
Lyrer, F. et al. (2023) Atrial fibrillation detected before or after stroke: role of anticoagulation. Annals of Neurology, 94(1), pp. 43-54. (doi: 10.1002/ana.26654) (PMID:36975022)
Mair, G. et al. (2023) Accuracy of artificial intelligence software for CT angiography in stroke. Annals of Clinical and Translational Neurology, 10(7), pp. 1072-1082. (doi: 10.1002/acn3.51790) (PMID:37208850) (PMCID:PMC10351662)
Cutforth, M. et al. (2023) Acute stroke CDS: automatic retrieval of thrombolysis contraindications from unstructured clinical letters. Frontiers in Digital Health, 5, 1186516. (doi: 10.3389/fdgth.2023.1186516) (PMID:37388253) (PMCID:PMC10305776)
Appleton, J. P. et al. (2023) Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial. Stroke and Vascular Neurology, (doi: 10.1136/svn-2022-001634) (PMID:37290930) (Early Online Publication)
Scheldeman, L. et al. (2023) Reversibility of diffusion-weighted imaging lesions in patients with ischemic stroke in the WAKE-UP trial. Stroke, (doi: 10.1161/STROKEAHA.122.041505) (PMID:37158080) (Early Online Publication)
Ding, B., Ghosalkar, J., Williams, S. , Forbes, K., Woodward, R., Dragonu, I., Porter, D., Muir, K. and Foo, S. Y. (2023) Vessel Wall Imaging at 7 Tesla Using 3D Turbo Spin-echo. SINAPSE Annual Scientific Meeting 2023, Glasgow, UK, 14 June 2023.
Quinn, T. J. and Muir, K. (2023) Do quality-of-life measures represent patient outcomes in stroke trials? Neurology, 100(13), pp. 597-598. (doi: 10.1212/WNL.0000000000206840) (PMID:36631271)
Dawson, J. et al. (2023) Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial. EClinicalMedicine, 57, 101863. (doi: 10.1016/j.eclinm.2023.101863) (PMID:36864979) (PMCID:PMC9972492)
McDonough, R. V. et al. (2023) Clinical outcome of patients with mild pre-stroke morbidity following endovascular treatment: a HERMES substudy. Journal of NeuroInterventional Surgery, 15(3), pp. 214-220. (doi: 10.1136/neurintsurg-2021-018428) (PMID:35210331)
Wouters, A. et al. (2023) Sex differences in imaging and clinical characteristics of patients from the WAKE-UP trial. European Journal of Neurology, 30(3), pp. 641-647. (doi: 10.1111/ene.15629) (PMID:36349887)
Mair, G., White, P., Bath, P., Muir, K. W. , Chappell, F. M. and Wardlaw, J. M. (2023) Reply to “independent confirmation”. Annals of Neurology, 93(2), p. 425. (doi: 10.1002/ana.26570) (PMID:36507582)
Jensen, M. et al. (2023) Patient-reported quality of life after intravenous alteplase for stroke in the WAKE-UP trial. Neurology, 100(2), e154-e162. (doi: 10.1212/WNL.0000000000201375) (PMID:36302662)
Ospel, J. M. et al. (2023) Cost-effectiveness of endovascular treatment in large vessel occlusion stroke with mild prestroke disability: results from the HERMES collaboration. Stroke, 54(1), pp. 226-233. (doi: 10.1161/STROKEAHA.121.038407) (PMID:36472199)
Schwarz, G. et al. (2023) MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage. International Journal of Stroke, 18(1), pp. 85-94. (doi: 10.1177/17474930211062478) (PMID:34994246)
2022
Gensicke, H. et al. (2022) Comparison of three scores of collateral status for their association with clinical outcome: the HERMES collaboration. Stroke, 53(12), pp. 3548-3556. (doi: 10.1161/STROKEAHA.122.039717) (PMID:36252099)
Mair, G. et al. (2022) External validation of e-ASPECTS software for interpreting brain CT in stroke. Annals of Neurology, 92(6), pp. 943-957. (doi: 10.1002/ana.26495) (PMID:36053916)
Tanaka, K. et al. (2022) Significance of baseline ischemic core volume on stroke outcome after endovascular therapy in patients age ≥75 years: a pooled analysis of individual patient data from 7 trials. Stroke, 53(12), pp. 3564-3571. (doi: 10.1161/strokeaha.122.039774) (PMID:36337054)
Schlemm, E. et al. (2022) Early effect of thrombolysis on structural brain network organisation after anterior‐circulation stroke in the randomized WAKE‐UP trial. Human Brain Mapping, 43(16), pp. 5053-5065. (doi: 10.1002/hbm.26073) (PMID:36102287) (PMCID:PMC9582379)
Braemswig, T. B. et al. (2022) New remote cerebral microbleeds in acute ischemic stroke: an analysis of the randomized, placebo-controlled WAKE-UP trial. Journal of Neurology, 269(10), pp. 5660-5667. (doi: 10.1007/s00415-022-11175-y) (PMID:35585334) (PMCID:PMC9468109)
Mahmood, A. and Muir, K. W. (2022) Tenecteplase or alteplase: what is the thrombolytic agent of the future? Current Treatment Options in Neurology, 24(10), pp. 503-513. (doi: 10.1007/s11940-022-00733-4) (PMID:35965955) (PMCID:PMC9362569)
Ng, F. C. et al. (2022) Correlation between computed tomography-based tissue net water uptake and volumetric measures of cerebral edema after reperfusion therapy. Stroke, 53(8), pp. 2628-2636. (doi: 10.1161/STROKEAHA.121.037073) (PMID:35450438)
Sharma, M. et al. (2022) Rivaroxaban versus aspirin for prevention of covert brain infarcts in patients with embolic stroke of undetermined source: NAVIGATE ESUS MRI substudy. International Journal of Stroke, 17(7), pp. 799-805. (doi: 10.1177/17474930211058012) (PMID:34791941)
Tolhuisen, M. L. et al. (2022) Outcome prediction based on automatically extracted infarct core image features in patients with acute ischemic stroke. Diagnostics, 12(8), 1786. (doi: 10.3390/diagnostics12081786) (PMID:35892499) (PMCID:PMC9331690)
McDonough, R. V. et al. (2022) Functional outcomes of patients ≥85 years with acute ischemic stroke following EVT: A HERMES substudy. Stroke, 53(7), pp. 2220-2226. (doi: 10.1161/strokeaha.121.037770) (PMID:35703094)
Barow, E. et al. (2022) Association of white blood cell count with clinical outcome independent of treatment with alteplase in acute ischemic stroke. Frontiers in Neurology, 13, 877367. (doi: 10.3389/fneur.2022.877367) (PMID:35769368) (PMCID:PMC9235538)
Muir, K. W. and Saposnik, G. (2022) Current state and future for emerging stroke therapies: reflections and reactions. Stroke, 53(6), pp. 2082-2084. (doi: 10.1161/STROKEAHA.122.039796) (PMID:35535598)
Scheldeman, L. et al. (2022) Diffusion-weighted imaging and fluid-attenuated inversion recovery quantification to predict diffusion-weighted imaging-fluid-attenuated inversion recovery mismatch status in ischemic stroke with unknown onset. Stroke, 53(5), pp. 1665-1673. (doi: 10.1161/STROKEAHA.121.036871) (PMID:35105179)
Jadhav, A. P. et al. (2022) Thrombectomy with and without computed tomography perfusion imaging in the early time window: a pooled analysis of patient-level data. Stroke, 53(4), pp. 1348-1353. (doi: 10.1161/STROKEAHA.121.034331) (PMID:34844423)
Schwarz, G. et al. (2022) Magnetic resonance imaging-based scores of small vessel diseases: associations with intracerebral haemorrhage location. Journal of the Neurological Sciences, 434, 120165. (doi: 10.1016/j.jns.2022.120165) (PMID:35121207)
Cheng, B. et al. (2022) Estimating nocturnal stroke onset times by magnetic resonance imaging in the WAKE-UP trial. International Journal of Stroke, 17(3), pp. 323-330. (doi: 10.1177/17474930211059608) (PMID:34791943)
Tolhuisen, M. L. et al. (2022) Value of infarct location in the prediction of functional outcome in patients with an anterior large vessel occlusion: results from the HERMES study. Neuroradiology, 64(3), pp. 521-530. (doi: 10.1007/s00234-021-02784-x) (PMID:34476512)
Schlemm, L. et al. (2022) Cerebral microbleeds and treatment effect of intravenous thrombolysis in acute stroke: an analysis of the WAKE-UP randomized clinical trial. Neurology, 98(3), e302-e314. (doi: 10.1212/WNL.0000000000013055) (PMID:34782419) (PMCID:PMC8792812)
Tunnage, B. et al. (2022) Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, 22(1), 2. (doi: 10.1186/s12873-021-00560-x) (PMID:35012462) (PMCID:PMC8744321)
Polymeris, A. A. et al. (2022) Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation. Annals of Neurology, 91(1), pp. 78-88. (doi: 10.1002/ana.26267) (PMID:34747514)
2021
Lettow, I. et al. (2021) Serious adverse events and their impact on functional outcome in acute ischemic stroke in the WAKE-UP trial. Stroke, 52(12), pp. 3768-3776. (doi: 10.1161/strokeaha.120.033425) (PMID:34433305)
Kappelhof, M. et al. (2021) Endovascular treatment effect diminishes with increasing thrombus perviousness. Stroke, 52(11), pp. 3633-3641. (doi: 10.1161/STROKEAHA.120.033124) (PMID:34281377) (PMCID:PMC8547583)
Ng, F. C. et al. (2021) Cerebral edema in patients with large hemispheric infarct undergoing reperfusion treatment: a HERMES meta-analysis. Stroke, 52(11), pp. 3450-3458. (doi: 10.1161/STROKEAHA.120.033246) (PMID:34384229)
Learmonth, G. , Benwell, C. S.Y., Märker, G., Dascalu, D., Checketts, M. , Santosh, C., Barber, M., Walters, M. , Muir, K. W. and Harvey, M. (2021) Non-invasive brain stimulation in stroke patients (NIBS): a prospective randomized open blinded end-point (PROBE) feasibility trial using transcranial direct current stimulation (tDCS) in post-stroke hemispatial neglect. Neuropsychological Rehabilitation, 31(8), pp. 1163-1189. (doi: 10.1080/09602011.2020.1767161) (PMID:32498606)
Venema, E. et al. (2021) Prediction of outcome and endovascular treatment benefit: validation and update of the MR PREDICTS decision tool. Stroke, 52(9), pp. 2764-2772. (doi: 10.1161/STROKEAHA.120.032935) (PMID:34266308) (PMCID:PMC8378416)
Zoetmulder, R. et al. (2021) Automated final lesion segmentation in posterior circulation acute ischemic stroke using deep learning. Diagnostics, 11(9), 1621. (doi: 10.3390/diagnostics11091621)
Ospel, J. M. et al. (2021) Comparing the prognostic impact of age and baseline National Institutes of Health Stroke Scale in acute stroke due to large vessel occlusion. Stroke, 52(9), pp. 2839-2845. (doi: 10.1161/STROKEAHA.120.032364) (PMID:34233465)
Almekhlafi, M. A. et al. (2021) Healthy life-year costs of treatment speed from arrival to endovascular thrombectomy in patients with ischemic stroke. JAMA Neurology, 78(6), pp. 709-717. (doi: 10.1001/jamaneurol.2021.1055) (PMID:33938914) (PMCID:PMC8094030)
Barow, E. et al. (2021) 24-hour blood pressure variability and treatment effect of intravenous alteplase in acute ischaemic stroke. European Stroke Journal, 6(2), pp. 168-175. (doi: 10.1177/23969873211014758)
Schlemm, E. et al. (2021) Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke. Nature Communications, 12, 2590. (doi: 10.1038/s41467-021-22786-w) (PMID:33972513) (PMCID:PMC8110812)
Schrempf, P., Watson, H., Park, E., Pajak, M., MacKinnon, H., Muir, K. W. , Harris-Birtill, D. and O'Neil, A. Q. (2021) Templated text synthesis for expert-guided multi-label extraction from radiology reports. Machine Learning and Knowledge Extraction, 3(2), pp. 299-317. (doi: 10.3390/make3020015)
Neves, K. B. , Morris, H., Alves-Lopes, R., Muir, K. W. , Moreton, F., Delles, C. , Montezano, A. C. and Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)
Jensen, M. et al. (2021) Polypharmacy, functional outcome, and treatment effect of intravenous alteplase for acute ischemic stroke. European Journal of Neurology, 28(2), pp. 532-539. (doi: 10.1111/ene.14566) (PMID:33015924)
Moreton, F. C., Cullen, B. , Dickie, D. A. , Lopez Gonzalez, R., Santosh, C., Delles, C. and Muir, K. W. (2021) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up. European Journal of Neurology, 28(1), pp. 220-228. (doi: 10.1111/ene.14534) (PMID:32931073)
Shoamanesh, A. et al. (2021) Microbleeds and the effect of anticoagulation in patients with embolic stroke of undetermined source: an exploratory analysis of the NAVIGATE ESUS randomized clinical trial. JAMA Neurology, 78(1), pp. 11-20. (doi: 10.1001/jamaneurol.2020.3836) (PMID:33074284) (PMCID:PMC7573796)
Königsberg, A. et al. (2021) Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study. Scientific Reports, 11, 13490. (doi: 10.1038/s41598-021-92865-x) (PMID:34188114) (PMCID:PMC8241844)
Malherbe, C. et al. (2021) Game-theoretical mapping of fundamental brain functions based on lesion deficits in acute stroke. Brain Communications, 3(3), fcab204. (doi: 10.1093/braincomms/fcab204) (PMID:34585140) (PMCID:PMC8473841)
2020
Du, H. et al. (2020) Small vessel disease and ischemic stroke risk during anticoagulation for atrial fibrillation after cerebral ischemia. Stroke, 52, pp. 91-99. (doi: 10.1161/STROKEAHA.120.029474) (PMID:33280548)
Clarke, W. T. et al. (2020) Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study. NeuroImage, 223, 117358. (doi: 10.1016/j.neuroimage.2020.117358) (PMID:32916289)
Katsanos, A. H. et al. (2020) Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis. European Journal of Neurology, 27(12), pp. 2453-2462. (doi: 10.1111/ene.14447) (PMID:32697894)
Frey, B. M. et al. (2020) Safety and efficacy of intravenous thrombolysis in stroke patients on prior antiplatelet therapy in the WAKE-UP trial. Neurological Research and Practice, 2, 40. (doi: 10.1186/s42466-020-00087-9) (PMID:33324940) (PMCID:PMC7678217)
Thomalla, G. et al. (2020) Intravenous alteplase for unknown time of onset stroke guided by advanced imaging: a systematic review and meta-analysis of individual patient data. Lancet, 396(10262), pp. 1574-1584. (doi: 10.1016/S0140-6736(20)32163-2) (PMID:33176180)
Best, J. G. et al. (2020) Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage. Neurology, 95(16), e2192-e2199. (doi: 10.1212/WNL.0000000000010788) (PMID:32934168) (PMCID:PMC7713790)
Heggie, R., Wu, O. , White, P., Ford, G. A., Wardlaw, J., Brown, M. M., Clifton, A. and Muir, K. W. (2020) Mechanical thrombectomy in patients with acute ischemic stroke: a cost-effectiveness and value of implementation analysis. International Journal of Stroke, 15(8), pp. 881-898. (doi: 10.1177/1747493019879656) (PMID:31564243)
Almarzouki, A. et al. (2020) Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage. Scientific Reports, 10, 15529. (doi: 10.1038/s41598-020-72504-7) (PMID:32968133) (PMCID:PMC7511300)
Barow, E. et al. (2020) Clinical characteristics and outcome of patients with lacunar infarcts and concurrent embolic ischemic lesions. Clinical Neuroradiology, 30, pp. 511-516. (doi: 10.1007/s00062-019-00800-5) (PMID:1161343)
Sales Barros, R. et al. (2020) Automatic segmentation of cerebral infarcts in follow-up computed tomography images with convolutional neural networks. Journal of NeuroInterventional Surgery, 12(9), pp. 848-852. (doi: 10.1136/neurintsurg-2019-015471) (PMID:31871069)
Thaventhiran, J. E. D. et al. (2020) Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 583, pp. 90-95. (doi: 10.1038/s41586-020-2265-1) (PMID:32499645)
Turro, E. et al. (2020) Whole-genome sequencing of patients with rare diseases in a national health system. Nature, 583(7814), pp. 96-102. (doi: 10.1038/s41586-020-2434-2) (PMID:32581362)
Banerjee, G. et al. (2020) Baseline factors associated with early and late death in intracerebral haemorrhage survivors. European Journal of Neurology, 27(7), pp. 1257-1263. (doi: 10.1111/ene.14238) (PMID:32223078)
Bivard, A. et al. (2020) Comparing mismatch strategies for patients being considered for ischemic stroke tenecteplase trials. International Journal of Stroke, 15(5), pp. 507-515. (doi: 10.1177/1747493019884529) (PMID:31684841)
Scheldeman, L. et al. (2020) Different mismatch concepts for MRI-guided thrombolysis in unknown onset stroke. Annals of Neurology, 87(6), pp. 931-938. (doi: 10.1002/ana.25730) (PMID:32227638)
Seiffge, D. J. et al. (2020) Ischemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation. Annals of Neurology, 87(5), pp. 677-687. (doi: 10.1002/ana.25700) (PMID:32052481) (PMCID:PMC7383617)
Kunz, W. G. et al. (2020) Public health and cost benefits of successful reperfusion after thrombectomy for stroke. Stroke, 51(3), pp. 899-907. (doi: 10.1161/STROKEAHA.119.027874) (PMID:31964289)
Muir, K. W. et al. (2020) Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). Journal of Neurology, Neurosurgery and Psychiatry, 91(4), pp. 396-401. (doi: 10.1136/jnnp-2019-322515) (PMID:32041820)
Clarke, W. T. et al. (2020) Multi-site harmonization of 7 Tesla MRI neuroimaging protocols. NeuroImage, 206, 116335. (doi: 10.1016/j.neuroimage.2019.116335) (PMID:31712167)
Banerjee, G. et al. (2020) Cognitive impairment prior to atrial fibrillation–related ischaemic events: neuroimaging and prognostic associations. Journal of the American Heart Association, 9(1), e014537. (doi: 10.1161/JAHA.119.014537) (PMID:31902325) (PMCID:PMC6988157)
Cheng, B. et al. (2020) Quantitative signal intensity in Fluid-Attenuated Inversion Recovery and treatment effect in the WAKE-UP trial. Stroke, 51(1), pp. 209-215. (doi: 10.1161/STROKEAHA.119.027390) (PMID:31662118)
2019
Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)
Hostettler, I. C. et al. (2019) C9orf72 and intracerebral haemorrhage. Neurobiology of Aging, 84, 237.e1-237.e3. (doi: 10.1016/j.neurobiolaging.2019.07.007) (PMID:31582231)
Schlemm, L. et al. (2019) Current smoking does not modify the treatment effect of intravenous thrombolysis in acute ischemic stroke patients—a post-hoc analysis of the WAKE-UP trial. Frontiers in Neurology, 10, 1239. (doi: 10.3389/fneur.2019.01239) (PMID:31824412) (PMCID:PMC6883001)
Kelleher, J. et al. (2019) Patient-specific iPSC model of a genetic vascular dementia syndrome reveals failure of mural cells to stabilize capillary structures. Stem Cell Reports, 13(5), pp. 817-831. (doi: 10.1016/j.stemcr.2019.10.004) (PMID:31680059) (PMCID:PMC6893064)
El-Tawil, S., Mair, G., Huang, X., Sakka, E., Palmer, J., Ford, I. , Kalra, L., Wardlaw, J. and Muir, K. W. (2019) Observer agreement on CT Perfusion imaging in acute ischemic stroke. Stroke, 50(11), pp. 3108-3114. (doi: 10.1161/STROKEAHA.119.026238) (PMID:31928512) (PMCID:PMC6824508)
Menon, B. K. et al. (2019) Efficacy of endovascular thrombectomy in patients with M2 segment middle cerebral artery occlusions: meta-analysis of data from the HERMES Collaboration. Journal of NeuroInterventional Surgery, 11(11), pp. 1065-1069. (doi: 10.1136/neurintsurg-2018-014678) (PMID:30975736)
Qiu, W. et al. (2019) Confirmatory study of time-dependent computed tomographic perfusion thresholds for use in acute ischemic stroke. Stroke, 50(11), pp. 3269-3273. (doi: 10.1161/STROKEAHA.119.026281) (PMID:31480968)
Deuchar, G. A., Van Kralingen, J. C., Work, L. M. , Santosh, C., Muir, K. W. , McCabe, C. and Macrae, I. M. (2019) Preclinical validation of the therapeutic potential of Glasgow Oxygen Level Dependent (GOLD) technology: A theranostic for acute stroke. Translational Stroke Research, 10(5), pp. 583-595. (doi: 10.1007/s12975-018-0679-y) (PMID:30506268)
Scheldeman, L. et al. (2019) Total mismatch in diffusion negative patients in the WAKE-UP trial. International Journal of Stroke, 14(7), NP20-NP22. (doi: 10.1177/1747493019875238) (PMID:31496439)
Galinovic, I. et al. (2019) Post-hoc analysis of outcome of intravenous thrombolysis in infarcts of infratentorial localization in the WAKE-UP trial. Frontiers in Neurology, 10, 983. (doi: 10.3389/fneur.2019.00983) (PMID:31572293) (PMCID:PMC6749039)
Chalos, V. et al. (2019) Does sex modify the effect of endovascular treatment for ischemic stroke? A subgroup analysis of seven randomized trials. Stroke, 50(9), pp. 2413-2419. (doi: 10.1161/STROKEAHA.118.023743) (PMID:31412753)
Leira, E. C. and Muir, K. W. (2019) EXTEND trial: Towards a more inclusive but complex thrombolysis. Stroke, 50(9), pp. 2637-2639. (doi: 10.1161/strokeaha.119.026249) (PMID:31449480)
Almekhlafi, M. et al. (2019) Stroke laterality did not modify outcomes in the HERMES meta-analysis of individual patient data of seven trials. Stroke, 50, pp. 2118-2124. (doi: 10.1161/STROKEAHA.118.023102) (PMID:31272328)
Kalladka, D., Sinden, J., McLean, J., Moreton, F. C., Huang, X. and Muir, K. W. (2019) Increased deep grey matter functional connectivity of poststroke hNSC implanted ipsilesional putamen. Journal of Neurology, Neurosurgery and Psychiatry, 90(8), pp. 959-960. (doi: 10.1136/jnnp-2018-319022) (PMID:30530567)
Wilson, D. et al. (2019) Potential missed opportunities to prevent ischaemic stroke: prospective multicentre cohort study of atrial fibrillation-associated ischaemic stroke and TIA. BMJ Open, 9(7), e028387. (doi: 10.1136/bmjopen-2018-028387) (PMID:31345970) (PMCID:PMC6661679)
Campbell, B. C. V. et al. (2019) Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet, 394(10193), pp. 139-147. (doi: 10.1016/S0140-6736(19)31053-0) (PMID:31128925)
Alexandrov, A. V. et al. (2019) Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke. Therapeutic Advances in Neurological Disorders, 12, (doi: 10.1177/1756286419860652) (PMID:31320933) (PMCID:PMC6628520)
Al-Shahi Salman, R. et al. (2019) Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial. Lancet Neurology, 18(7), pp. 643-652. (doi: 10.1016/S1474-4422(19)30184-X) (PMID:31129065)
Wilson, D. et al. (2019) Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurology, 18(7), pp. 653-665. (doi: 10.1016/S1474-4422(19)30197-8) (PMID:31130428) (PMCID:PMC6562236)
Al-Shahi Salman, R. et al. (2019) Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial. Lancet, 393(10191), pp. 2613-2623. (doi: 10.1016/S0140-6736(19)30840-2) (PMID:31128924) (PMCID:PMC6617509)
Muir, K. W. and Yan, B. (2019) Perfusion imaging INSPIREs precision medicine in stroke. Neurology, 92(23), pp. 1075-1076. (doi: 10.1212/WNL.0000000000007554) (PMID:31043470)
Barrow, E. et al. (2019) Functional outcome of intravenous thrombolysis in patients with lacunar infarcts in the WAKE-UP trial. JAMA Neurology, 76(6), pp. 641-649. (doi: 10.1001/jamaneurol.2019.0351) (PMID:30907934)
Seiffge, D. J. et al. (2019) Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation. Annals of Neurology, 85(6), pp. 823-834. (doi: 10.1002/ana.25489) (PMID:30980560) (PMCID:PMC6563449)
Banerjee, G. et al. (2019) Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. Journal of Neurology, 266(5), pp. 1250-1259. (doi: 10.1007/s00415-019-09256-6) (PMID:30847646) (PMCID:PMC6469837)
Damion, R. A. et al. (2019) Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients. Physics in Medicine and Biology, 64(9), 095016. (doi: 10.1088/1361-6560/ab1442) (PMID:30921782)
Liebeskind, D. S. et al. (2019) eTICI reperfusion: defining success in endovascular stroke therapy. Journal of NeuroInterventional Surgery, 11(5), pp. 433-438. (doi: 10.1136/neurintsurg-2018-014127) (PMID:30194109)
Alexandrov, A. V. et al. (2019) Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurology, 18(4), pp. 338-347. (doi: 10.1016/S1474-4422(19)30026-2) (PMID:30878103)
Bourcier, R. et al. (2019) Association of time from stroke onset to groin puncture with quality of reperfusion after mechanical thrombectomy: a meta-analysis of individual patient data From 7 randomized clinical trials. JAMA Neurology, 76(4), pp. 405-411. (doi: 10.1001/jamaneurol.2018.4510) (PMID:30667465) (PMCID:PMC6459219)
Bath, P. M. et al. (2019) Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet, 393(10175), pp. 1009-1020. (doi: 10.1016/S0140-6736(19)30194-1) (PMID:30738649) (PMCID:PMC6497986)
Chamorro, A. et al. (2019) Glucose modifies the effect of endovascular thrombectomy in patients with acute stroke: a pooled-data meta-analysis. Stroke, 50(3), pp. 690-696. (doi: 10.1161/STROKEAHA.118.023769) (PMID:30777000)
Goyal, M. et al. (2019) Rapid alteplase administration improves functional outcomes in patients with stroke due to large vessel occlusions. Stroke, 50(3), pp. 645-651. (doi: 10.1161/STROKEAHA.118.021840) (PMID:30760169)
Boers, A. M. M. et al. (2019) Mediation of the relationship between endovascular therapy and functional outcome by follow-up infarct volume in patients with acute ischemic stroke. JAMA Neurology, 76(2), pp. 194-202. (doi: 10.1001/jamaneurol.2018.3661) (PMID:30615038)
Tilling, E. J., El Tawil, S. and Muir, K. W. (2019) Do clinicians overestimate the severity of intracerebral hemorrhage? Stroke, 50(2), pp. 344-348. (doi: 10.1161/STROKEAHA.118.022606) (PMID:30626290)
Campbell, B. C.V. et al. (2019) Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data. Lancet Neurology, 18(1), pp. 46-55. (doi: 10.1016/S1474-4422(18)30314-4) (PMID:30413385)
Harvey, M. , Muir, K. , Benwell, C., Walters, M. and Learmonth, G. (2019) Feasibility of Applying Non-invasive Brain Stimulation to Induce Recovery from Neglect. 5th European Stroke Organisation Conference (ESOC 2019), Milan, Italy, 22-24 May 2019.
Rossit, S. et al. (2019) Efficacy of home-based visuomotor feedback training in stroke patients with chronic hemispatial neglect. Neuropsychological Rehabilitation, 29(2), pp. 251-272. (doi: 10.1080/09602011.2016.1273119) (PMID:28116988)
2018
Learmonth, G. , Muir, K.W. , Benwell, C., Walters, M. and Harvey, M. (2018) Recruitment Issues with Non-invasive Brain Stimulation in Stroke Patients. UK Stroke Forum 2018, Telford, UK, 4-6 Dec 2018. (doi: 10.1177/1747493018801108)
Boers, A. M.M. et al. (2018) Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials. Journal of NeuroInterventional Surgery, 10(12), pp. 1137-1142. (doi: 10.1136/neurintsurg-2017-013724) (PMID:29627794)
Coutts, S.B., Berge, E., Campbell, B.C.V., Muir, K.W. and Parsons, M.W. (2018) Tenecteplase for the treatment of acute ischemic stroke: a review of completed and ongoing randomized controlled trials. International Journal of Stroke, 13(9), pp. 885-892. (doi: 10.1177/1747493018790024) (PMID:30035698)
Kasner, S. E. et al. (2018) Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial. Lancet Neurology, 17(12), pp. 1053-1060. (doi: 10.1016/S1474-4422(18)30319-3) (PMID:30274772)
Al-Shahi Salman, R. et al. (2018) Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data. Lancet Neurology, 17(10), pp. 885-894. (doi: 10.1016/S1474-4422(18)30253-9) (PMID:30120039) (PMCID:PMC6143589)
Hoving, J. W. et al. (2018) Volumetric and spatial accuracy of CTP estimated ischemic core volume in patients with acute ischemic stroke. Stroke, 49(10), pp. 2368-2375. (doi: 10.1161/STROKEAHA.118.020846) (PMID:30355095)
San Roman, L. et al. (2018) Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data. Lancet Neurology, 17(10), pp. 895-904. (doi: 10.1016/S1474-4422(18)30242-4) (PMID:30264728)
Dawson, J. et al. (2018) Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) – Protocol for a randomised double blind placebo-controlled clinical trial. European Stroke Journal, 3(3), pp. 281-290. (doi: 10.1177/2396987318771426) (PMID:30246149) (PMCID:PMC6120121)
Thomalla, G. et al. (2018) MRI-guided thrombolysis for stroke with unknown time of onset. New England Journal of Medicine, 379(7), pp. 611-622. (doi: 10.1056/NEJMoa1804355) (PMID:29766770)
Detante, O., Muir, K. and Jolkkonen, J. (2018) Cell therapy in stroke—cautious steps towards a clinical treatment. Translational Stroke Research, 9(4), pp. 321-332. (doi: 10.1007/s12975-017-0587-6) (PMID:29150739)
Hart, R. G. et al. (2018) Rivaroxaban for secondary stroke prevention after embolic stroke of undetermined source. New England Journal of Medicine, 378(23), pp. 2191-2201. (doi: 10.1056/NEJMoa1802686) (PMID:29766772)
Kasner, S. E. et al. (2018) Characterization of patients with embolic strokes of undetermined source in the NAVIGATE ESUS randomized trial. Journal of Stroke and Cerebrovascular Diseases, 27(6), pp. 1673-1682. (doi: 10.1016/j.jstrokecerebrovasdis.2018.01.027) (PMID:29525076)
Moreton, F. C., Cullen, B. , Delles, C. , Santosh, C., Lopez Gonzalez, R., Dani, K. and Muir, K. W. (2018) Vasoreactivity in CADASIL: comparison to structural MRI and neuropsychology. Journal of Cerebral Blood Flow and Metabolism, 38(6), pp. 1085-1095. (doi: 10.1177/0271678X17710375) (PMID:28537106)
Wilson, D. et al. (2018) Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study. Lancet Neurology, 17(6), pp. 539-547. (doi: 10.1016/S1474-4422(18)30145-5) (PMID:29778365) (PMCID:PMC5956310)
Al-Shahi Salman, R. et al. (2018) The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19, 162. (doi: 10.1186/s13063-018-2542-6) (PMID:29506580) (PMCID:PMC5838871)
Banerjee, G. et al. (2018) Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke, 49(1), pp. 40-45. (doi: 10.1161/STROKEAHA.117.019409) (PMID:29247143) (PMCID:PMC5753815)
Campbell, B. C.V. et al. (2018) Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data. Lancet Neurology, 17(1), pp. 47-53. (doi: 10.1016/S1474-4422(17)30407-6) (PMID:29263006)
Thomalla, G. et al. (2018) Clinical characteristics of unknown symptom onset stroke patients with and without diffusion-weighted imaging and fluid-attenuated inversion recovery mismatch. International Journal of Stroke, 13(1), pp. 66-73. (doi: 10.1177/1747493017706245) (PMID:28425349)
Thow, L. A., MacDonald, K., Holmes, W. M. , Muir, K. W. , Macrae, I. M. and Dewar, D. (2018) Hyperglycaemia does not increase perfusion deficits after focal cerebral ischaemia in male Wistar rats. Brain and Neuroscience Advances, 2, pp. 1-13. (doi: 10.1177/2398212818794820)
2017
Huang, X., Kalladka, D., Cheripelli, B. K., Moreton, F. C. and Muir, K. W. (2017) The impact of CT perfusion threshold on predicted viable and nonviable tissue volumes in acute ischaemic stroke. Journal of Neuroimaging, 27(6), pp. 602-606. (doi: 10.1111/jon.12442) (PMID:28414895)
Thomalla, G. et al. (2017) Effect of informed consent on patient characteristics in a stroke thrombolysis trial. Neurology, 89(13), pp. 1400-1407. (doi: 10.1212/WNL.0000000000004414) (PMID:28842449)
Moreton, F. C., Düring, M., Phan, T., Srikanth, V., Beare, R., Huang, X., Jouvent, E., Chabriat, H., Dichgans, M. and Muir, K. W. (2017) Arterial branching and basal ganglia lacunes: a study in pure small vessel disease. European Stroke Journal, 2(3), pp. 264-271. (doi: 10.1177/2396987317718450)
El-Tawil, S., Wardlaw, J., Ford, I. , Mair, G., Robinson, T., Kalra, L. and Muir, K. W. (2017) Penumbra and re-canalization acute computed tomography in ischemic stroke evaluation: PRACTISE study protocol. International Journal of Stroke, 12(6), pp. 671-678. (doi: 10.1177/1747493017696099) (PMID:28730951)
Bivard, A. et al. (2017) Tenecteplase in ischemic stroke offers improved recanalization: analysis of 2 trials. Neurology, 89(1), pp. 62-67. (doi: 10.1212/WNL.0000000000004062) (PMID:28576782)
Bivard, A., Muir, K. and Parsons, M. (2017) Response by Bivard et al to letter regarding article, "Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials". Circulation, 135(24), e1141-e1142. (doi: 10.1161/CIRCULATIONAHA.117.028417) (PMID:28606957)
McVerry, F., McCluskey, G., McCarron, P., Muir, K. W. and McCarron, M. O. (2017) Diagnostic test results in primary CNS vasculitis: a systematic review of published cases. Neurology: Clinical Practice, 7(3), pp. 256-265. (doi: 10.1212/CPJ.0000000000000359)
Muir, K. W. (2017) Clinical trial design for stem cell therapies in stroke: What have we learned? Neurochemistry International, 106, pp. 108-113. (doi: 10.1016/j.neuint.2016.09.011) (PMID:27623094)
Learmonth, G. , Benwell, C.S.Y., Walters, M. , Muir, K. and Harvey, M. (2017) Feasibility of Multi-Session tDCS in Rehabilitating Post-Stroke Hemispatial Neglect. 2nd International Congress on NeuroRehabilitation and Neural Repair, Maastricht, The Netherlands, 22-24 May 2017.
Maxwell, A. E. et al. (2017) Reasons for non-recruitment of eligible patients to a randomised controlled trial of secondary prevention after intracerebral haemorrhage: observational study. Trials, 18(1), 162. (doi: 10.1186/s13063-017-1909-4) (PMID:28381307) (PMCID:PMC5382439)
El Tawil, S. and Muir, K. W. (2017) Thrombolysis and thrombectomy for acute ischaemic stroke. Clinical Medicine, 17(2), pp. 161-165. (doi: 10.7861/clinmedicine.17-2-161) (PMID:28365630)
Muir, K. W. (2017) Stroke in the acute setting. Medicine, 45(3), pp. 163-168. (doi: 10.1016/j.mpmed.2016.12.008)
Thomalla, G. et al. (2017) Stroke with unknown time of symptom onset: baseline clinical and magnetic resonance imaging data of the first thousand patients in WAKE-UP (efficacy and safety of mri-based thrombolysis in wake-up stroke: a randomized, doubleblind, placebo-controlled trial). Stroke, 48(3), pp. 770-773. (doi: 10.1161/STROKEAHA.116.015233) (PMID:28174327)
Bivard, A. et al. (2017) Impact of computed tomography perfusion imaging on the response to tenecteplase in ischemic stroke: analysis of two randomized controlled trials. Circulation, 135(5), pp. 440-448. (doi: 10.1161/CIRCULATIONAHA.116.022582) (PMID:27965285)
Dani, K. A., Moreton, F. C., Santosh, C., Lopez, R., Brennan, D., Schwarzbauer, C., Goutcher, C., O’Hare, K., Macrae, I. M. and Muir, K. W. (2017) Oxygen challenge magnetic resonance imaging in healthy human volunteers. Journal of Cerebral Blood Flow and Metabolism, 37(1), pp. 366-376. (doi: 10.1177/0271678x15627827) (PMID:26787107) (PMCID:PMC5363753)
Muir, K. W. et al. (2017) Endovascular therapy for acute ischemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. Journal of Neurology, Neurosurgery and Psychiatry, 88(1), pp. 38-44. (doi: 10.1136/jnnp-2016-314117) (PMID:27756804)
Heggie, R., Wu, O. , White, P., Ford, G. A., Wardlaw, J., Brown, M. M., Clifton, A. and Muir, K. W. (2017) Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Cost-Effectiveness and Value of Implementation Analysis. ISPOR 20th Annual European Congress, Glasgow, UK, 4-8 Nov 2017.
Heggie, R., Wu, O. , White, P., Ford, G. A., Wardlaw, J., Brown, M. M., Clifton, A. and Muir, K. W. (2017) Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Cost-Effectiveness and Value of Implementation Analysis. 3rd European Stroke Organisation Conference (ESOC), Prague, Czech Republic, 16-18 May 2017.
Hinman, J. D., Rost, N. S., Leung, T. W., Montaner, J., Muir, K. W. , Brown, S., Arenillas, J. F., Feldmann, E. and Liebeskind, D. S. (2017) Principles of precision medicine in stroke. Journal of Neurology, Neurosurgery and Psychiatry, 88, pp. 54-61. (doi: 10.1136/jnnp-2016-314587) (PMID:27919057)
2016
El Tawil, S., Cheripelli, B., Huang, X., Moreton, F., Kalladka, D., MacDougal, N. J.J., McVerry, F. and Muir, K. W. (2016) How many stroke patients might be eligible for mechanical thrombectomy? European Stroke Journal, 1(4), pp. 264-271. (doi: 10.1177/2396987316667176)
Muir, K. W. and Macrae, I. M. (2016) Neuroimaging as a selection tool and endpoint in preclinical and clinical trials. Translational Stroke Research, 7(5), pp. 368-377. (doi: 10.1007/s12975-016-0487-1) (PMID:27543177)
Hart, R. G. et al. (2016) Rivaroxaban for secondary stroke prevention in patients with embolic strokes of undetermined source: design of the NAVIGATE ESUS randomized trial. European Stroke Journal, 1(3), pp. 146-154. (doi: 10.1177/2396987316663049)
Perera, K. S. et al. (2016) Global survey of the frequency of atrial fibrillation-associated stroke: embolic stroke of undetermined source global registry. Stroke, 47(9), pp. 2197-2202. (doi: 10.1161/STROKEAHA.116.013378) (PMID:27507860)
Kalladka, D. et al. (2016) Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet, 388(10046), pp. 787-796. (doi: 10.1016/S0140-6736(16)30513-X) (PMID:27497862)
Fiehler, J., Cognard, C., Gallitelli, M., Jansen, O., Kobayashi, A., Mattle, H. P., Muir, K. W. , Mazighi, M., Schaller, K. and Schellinger, P. D. (2016) European recommendations on organisation of interventional care in acute stroke (EROICAS). International Journal of Stroke, 11(6), pp. 701-716. (doi: 10.1177/1747493016647735) (PMID:27462090)
Muir, K. (2016) No space Left for Intravenous thrombolysis in acute stroke. Internal and Emergency Medicine, 11, 619. (doi: 10.1007/s11739-016-1448-0)
Perera, K. S. et al. (2016) Embolic strokes of undetermined source: prevalence and patient features in the ESUS Global Registry. International Journal of Stroke, 11(5), pp. 526-533. (doi: 10.1177/1747493016641967) (PMID:27256472)
Cheripelli, B. K., Huang, X., MacIsaac, R. and Muir, K. W. (2016) Interaction of recanalization, intracerebral hemorrhage, and cerebral edema after intravenous thrombolysis. Stroke, 47(7), pp. 1761-1767. (doi: 10.1161/STROKEAHA.116.013142) (PMID:27301943)
Huang, X. et al. (2016) Tenecteplase versus alteplase in stroke thrombolysis: an individual patient data meta-analysis of randomized controlled trials. International Journal of Stroke, 11(5), pp. 534-543. (doi: 10.1177/1747493016641112) (PMID:27048693)
Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M. , Stewart, W. , Condon, B., Muir, K.W. , Welch, G. and Forbes, K.P. (2016) Atherosclerotic carotid plaque composition: a 3T and 7T MRI-histology correlation study. Journal of Neuroimaging, 26(4), pp. 406-413. (doi: 10.1111/jon.12332) (PMID:26919134)
Cullen, B. , Moreton, F. C., Stringer, M. S., Krishnadas, R. , Kalladka, D., López-González, M. R., Santosh, C., Schwarzbauer, C. and Muir, K. W. (2016) Resting state connectivity and cognitive performance in adults with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Journal of Cerebral Blood Flow and Metabolism, 36(5), pp. 981-991. (doi: 10.1177/0271678X16636395) (PMID:26929239)
Cheripelli, B. K., Huang, X., McVerry, F. and Muir, K. (2016) What is the relationship among penumbra volume, collaterals, and time since onset in the first 6 h after acute ischemic stroke? International Journal of Stroke, 11(3), pp. 338-346. (doi: 10.1177/1747493015620807) (PMID:26763919)
Merenda, A., Muir, K. W. and Koch, S. (2016) Cracking the role of cocaine in stroke. Stroke, 47(4), pp. 909-910. (doi: 10.1161/strokeaha.116.012681) (PMID:26965852)
Muir, K. W. and White, P. (2016) HERMES: messenger for stroke interventional treatment. Lancet, 387(10029), pp. 1695-1697. (doi: 10.1016/s0140-6736(16)00351-2) (PMID:26898854)
Østergaard, L., Engedal, T. S., Moreton, F., Hansen, M. B., Wardlaw, J. M., Dalkara, T., Markus, H. S. and Muir, K. W. (2016) Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline. Journal of Cerebral Blood Flow and Metabolism, 36(2), pp. 302-325. (doi: 10.1177/0271678X15606723) (PMID:26661176) (PMCID:PMC4759673)
Moreton, F. C., Dani, K. A., Goutcher, C., O'Hare, K. and Muir, K. W. (2016) Respiratory challenge MRI: practical aspects. NeuroImage: Clinical, 11, pp. 667-677. (doi: 10.1016/j.nicl.2016.05.003)
Warach, S. J. et al. (2016) Acute stroke imaging research roadmap III imaging selection and outcomes in acute stroke reperfusion clinical trials. Stroke, 47(5), pp. 1389-1398. (doi: 10.1161/strokeaha.115.012364) (PMID:27073243)
2015
Moreton, F., Santosh, C., McArthur, K. and Muir, K. (2015) Cerebral hyperperfusion on arterial spin labeling MRI during CADASIL migrainous encephalopathy. Neurology, 85(24), pp. 2177-2179. (doi: 10.1212/WNL.0000000000002214) (PMID:26567267)
Huang, X., Moreton, F., Kalladka, D., Cheripelli, B. K., Macisaac, R., Tait, R. C. and Muir, K. (2015) Coagulation and fibrinolytic activity of tenecteplase and alteplase in acute ischemic stroke. Stroke, 46(12), pp. 3543-3546. (doi: 10.1161/strokeaha.115.011290) (PMID:26514192)
Macisaac, R. L. et al. (2015) A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy and tPA (TREAT) analysis: statistical analysis plan for a sequential meta-anal. International Journal of Stroke, 10(Sup), pp. 136-144. (doi: 10.1111/ijs.12622) (PMID:26352438)
Muir, K. W. and Sinden, J. D. (2015) The CTX Human Neural Stem Cell Line and the PISCES Stroke Trial. In: Hess, D. C. (ed.) Cell Therapy for Brain Injury. Springer, pp. 111-128. ISBN 9783319150628 (doi: 10.1007/978-3-319-15063-5_8)
Huang, X., Cheripelli, B. K., Lloyd, S. M. , Kalladka, D., Moreton, F. C., Siddiqui, A., Ford, I. and Muir, K. W. (2015) Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST): phase 2 randomised clinical trial. Lancet Neurology, 14(4), pp. 368-376. (doi: 10.1016/S1474-4422(15)70017-7) (PMID:25726502)
Ramani, L., Huang, X., Cheripelli, B. and Muir, K. W. (2015) Intravenous thrombolysis for acute stroke: current standards and future directions. Current Treatment Options in Cardiovascular Medicine, 17(3), 16. (doi: 10.1007/s11936-015-0373-2) (PMID:25778425)
Wollenweber, F.A. et al. (2015) Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro. Stroke, 46(3), pp. 786-792. (doi: 10.1161/STROKEAHA.114.007472) (PMID:25604251)
Saver, J. L. et al. (2015) Prehospital use of magnesium sulfate as neuroprotection in acute stroke. New England Journal of Medicine, 372(6), pp. 528-536. (doi: 10.1056/NEJMoa1408827) (PMID:25651247) (PMCID:PMC4920545)
Khatri, P. et al. (2015) State of acute endovascular therapy: report from the 12th thrombolysis, Thrombectomy, and acute stroke therapy conference. Stroke, 46(6), pp. 1727-1734. (doi: 10.1161/STROKEAHA.115.008782) (PMID:25944325)
2014
McVerry, F., Dani, K. A., MacDougall, N. J.J., Macleod, M. J., Wardlaw, J. and Muir, K. W. (2014) Derivation and evaluation of thresholds for core and tissue at risk of infarction using CT perfusion. Journal of Neuroimaging, 24(6), pp. 562-568. (doi: 10.1111/jon.12134)
Urfer, R., Moebius, H. J., Skoloudik, D., Santamarina, E., Sato, W., Mita, S. and Muir, K. W. (2014) Phase II trial of the sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke. Stroke, 45(11), pp. 3304-3310. (doi: 10.1161/STROKEAHA.114.005835) (PMID:25270629)
Thomalla, G. et al. (2014) A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP). International Journal of Stroke, 9(6), pp. 829-836. (doi: 10.1111/ijs.12011)
Kalladka, D. and Muir, K. W. (2014) Brain repair: cell therapy in stroke. Stem Cells and Cloning: Advances and Applications, 2014(7), pp. 31-44. (doi: 10.2147/SCCAA.S38003) (PMID:24627643) (PMCID:PMC3937183)
Brazzelli, M., Chappell, F. M., Miranda, H., Shuler, K., Dennis, M., Sandercock, P. A. G., Muir, K. and Wardlaw, J. M. (2014) Diffusion-weighted imaging and diagnosis of transient ischemic attack. Annals of Neurology, 75(1), pp. 67-76. (doi: 10.1002/ana.24026) (PMID:24085376) (PMCID:PMC4223937)
Moreton, F., Razvi, S., Davidson, R. and Muir, K. (2014) Changing clinical patterns and increasing prevalence in CADASIL. Acta Neurologica Scandinavica, 130(3), pp. 197-203. (doi: 10.1111/ane.12266)
Robertson, C. A., McCabe, C. , Lopez-Gonzalez, M. R., Deuchar, G. A., Dani, K., Holmes, W. M. , Muir, K. W. , Santosh, C. and Macrae, I. M. (2014) Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. International Journal of Stroke, 10(1), pp. 42-50. (doi: 10.1111/ijs.12327)
Rodie, M. E., Forbes, K. P. and Muir, K. (2014) Advances in neuroimaging. In: Hiort, O. and Ahmed, S.F. (eds.) Understanding Differences and Disorders of Sex Development (DSD). Series: Endocrine development (27). Karger: Basel, pp. 63-75. ISBN 9783318025583 (doi: 10.1159/000363628)
Savitz, S. I. et al. (2014) Stem cells as an emerging paradigm in Stroke 3: enhancing the development of clinical trials. Stroke, 45(2), pp. 634-639. (doi: 10.1161/STROKEAHA.113.003379)
2013
Hill, M. and Muir, K.W. (2013) INTERACT-2: should blood pressure be aggressively lowered acutely after intracerebral hemorrhage? Stroke, 44(10), pp. 2951-2952. (doi: 10.1161/STROKEAHA.113.002790)
Muir, K.W. (2013) STICH 2: does decompression have a role in superficial intracerebral hematoma? International Journal of Stroke, 8(7), pp. 540-541. (doi: 10.1111/ijs.12182)
Brazzelli, M., Shuler, K., Quayyum, Z., Hadley, D., Muir, K. , McNamee, P., De Wilde, J., Dennis, M., Sandercock, P. and Wardlaw, J. M. (2013) Clinical and imaging services for TIA and minor stroke: results of two surveys of practice across the UK. BMJ Open, 3(8), e003359. (doi: 10.1136/bmjopen-2013-003359)
Scalzo, F. et al. (2013) Multi-center prediction of hemorrhagic transformation in acute ischemic stroke using permeability imaging features. Magnetic Resonance Imaging, 31(6), pp. 961-969. (doi: 10.1016/j.mri.2013.03.013)
Rossit, R., Olsen, L., Butler, S., Muir, K. and Harvey, M. (2013) The neural basis of reflexive and volitional saccades: evidence from lesion-symptom mapping with stroke patients. Behavioural Neurology, 27(3), pp. 388-389. (doi: 10.3233/BEN-139900)
Tarr, D., Graham, D. , Roy, L.A., Holmes, W.M. , McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi: 10.1038/jcbfm.2013.107)
van der Hoeven, E.J.R.J. et al. (2013) The Basilar artery international cooperation study (BASICS): study protocol for a randomised controlled trial. Trials, 14(200), (doi: 10.1186/1745-6215-14-200)
Wintermark, M. et al. (2013) Acute stroke imaging research roadmap II. Stroke, 44(9), pp. 2628-2639. (doi: 10.1161/STROKEAHA.113.002015)
2012
Dani, K.A., Santosh, C., Brennan, D., Hadley, D.M. and Muir, K.W. (2012) Crossed cerebellar diaschisis: insights into oxygen challenge MRI. Journal of Cerebral Blood Flow and Metabolism, 32(12), pp. 2114-2117. (doi: 10.1038/jcbfm.2012.142)
Muir, K.W. (2012) Imaging and treatment response after ischaemic stroke. Lancet Neurology, 11(10), pp. 838-839. (doi: 10.1016/S1474-4422(12)70207-7)
Sinden, J.D. and Muir, K.W. (2012) Stem cells in stroke treatment: the promise and the challenges. International Journal of Stroke, 7(5), pp. 426-434. (doi: 10.1111/j.1747-4949.2012.00840.x)
Rossit, S., McIntosh, R.D., Malhotra, P., Butler, S.H., Muir, K. and Harvey, M. (2012) Attention in action: evidence from on-line corrections in left visual neglect. Neuropsychologia, 50(6), pp. 1124-1135. (doi: 10.1016/j.neuropsychologia.2011.10.004)
Cooper, S.A., Joshi, A.C., Seenan, P.J., Hadley, D.M., Muir, K.W. , Leigh, R.J. and Metcalfe, R.A. (2012) Akinetopsia: acute presentation and evidence for persisting defects in motion vision. Journal of Neurology, Neurosurgery and Psychiatry, 83(2), pp. 229-230. (doi: 10.1136/jnnp.2010.223727)
Dani, K.A., Thomas, R.G.R., Chappell, F.M., Shuler, K., Muir, K.W. and Wardlaw, J.M. (2012) Systematic review of perfusion imaging with computed tomography and magnetic resonance in acute ischemic stroke: heterogeneity of acquisition and postprocessing parameters: a translational medicine research collaboration multicentre acute stroke imaging study. Stroke, 43(2), pp. 563-566. (doi: 10.1161/STROKEAHA.111.629923)
McVerry, F., Liebeskind, D.S. and Muir, K.W. (2012) Systematic review of methods for assessing leptomeningeal collateral flow. American Journal of Neuroradiology, 33(3), pp. 576-582. (doi: 10.3174/ajnr.A2794)
2011
Rossit, S., Malhotra, P., Muir, K. , Reeves, I., Duncan, G. and Harvey, M. (2011) The role of right temporal lobe structures in off-line action: evidence from lesion-behavior mapping in stroke patients. Cerebral Cortex, 21(12), pp. 2751-2761. (doi: 10.1093/cercor/bhr073)
Dani, K.A., Thomas, R.G.R., Chappell, F.M., Shuler, K., MacLeod, M.J., Muir, K.W. and Wardlaw, J.M. (2011) Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds. Annals of Neurology, 70(3), pp. 384-401. (doi: 10.1002/ana.22500)
Kalladka, D. and Muir, K.W. (2011) Stem cell therapy in stroke: designing clinical trials. Neurochemistry International, 59(3), pp. 367-370. (doi: 10.1016/j.neuint.2011.03.016)
Robertson, C. A., McCabe, C. , Gallagher, L., Lopez Gonzalez, M. d., Holmes, W. M. , Condon, B., Muir, K. W. , Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1788-1798. (doi: 10.1038/jcbfm.2011.67)
Robertson, C. A., McCabe, C. , Gallagher, L., Lopez-Gonzalez, M. d., Holmes, W. M. , Condon, B., Muir, K. W. , Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31, pp. 1778-1787. (doi: 10.1038/jcbfm.2011.66)
MacDougall, N.J.J., McVerry, F., Baird, S., Baird, T., Teasdale, E. and Muir, K.W. (2011) Iodinated contrast media and cerebral hemorrhage after intravenous thrombolysis. Stroke, 42(8), pp. 2170-2174. (doi: 10.1161/STROKEAHA.111.618777)
Harvey, M. et al. (2011) Long term improvements in activities of daily living in patients with hemispatial neglect. Behavioural Neurology, 23(4), pp. 237-239. (doi: 10.3233/BEN-2010-0304)
MacDougall, N.J.J. and Muir, K. (2011) Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis. Journal of Cerebral Blood Flow and Metabolism, 31(3), pp. 807-818. (doi: 10.1038/jcbfm.2010.210)
Muir, K.W. , Sinden, J., Miljan, E. and Dunn, L. (2011) Intracranial delivery of stem cells. Translational Stroke Research, 2(3), pp. 266-271. (doi: 10.1007/s12975-011-0095-z)
Nagakane, Y. et al. (2011) EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration. Stroke, 42(1), pp. 59-64. (doi: 10.1161/STROKEAHA.110.580464)
Puetz, V. et al. (2011) Extent of hypoattenuation on CT angiography source images in Basilar Artery occlusion: prognostic value in the Basilar Artery International Cooperation Study. Stroke, 42(12), pp. 3454-3459. (doi: 10.1161/STROKEAHA.111.622175)
2010
Dani, K. A., Santosh, C., Brennan, D., McCabe, C. , Holmes, W. M. , Condon, B., Hadley, D. M., Macrae, I. M., Shaw, M. and Muir, K. W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68(1), pp. 37-47. (doi: 10.1002/ana.22032)
Crozier, J. E. M., Reid, J., Welch, G., Muir, K.W. and Stuart, W. (2010) Early carotid endarterectomy following thrombolysis in the hyperacute treatment of stroke. British Journal of Surgery, 98(2), pp. 235-238. (doi: 10.1002/bjs.7306)
Awadh, M., MacDougall, N., Santosh, C., Teasdale, E., Baird, T. and Muir, K.W. (2010) Early recurrent ischemic stroke complicating intravenous thrombolysis for stroke: incidence and association with atrial fibrillation. Stroke, 41(9), pp. 1990-1995. (doi: 10.1161/STROKEAHA.109.569459)
Dani, K.A. and Muir, K.W. (2010) Do iodinated contrast agents impair fibrinolysis in acute stroke? A systematic review. American Journal of Neuroradiology, 31(1), pp. 170-174. (doi: 10.3174/ajnr.A1782)
McCormick, M., Hadley, D., McLean, J. R., Macfarlane, J. A., Condon, B. and Muir, K. W. (2010) Randomized, Controlled Trial of Insulin for Acute Poststroke Hyperglycemia. Annals of Neurology, 67(5), pp. 570-578. (doi: 10.1002/ana.21983)
2009
Rossit, S., Malhotra, P., Muir, K. , Reeves, I., Duncan, G., Birschel, P. and Harvey, M. (2009) The neural basis of visuomotor deficits in hemispatial neglect. Neuropsychologia, 47(10), pp. 2149-2153. (doi: 10.1016/j.neuropsychologia.2009.04.015)
Rossit, S., Muir, K. , Reeves, I., Duncan, G., Birschel, P. and Harvey, M. (2009) Immediate and delayed reaching in hemispatial neglect. Neuropsychologia, 47(6), pp. 1563-1572. (doi: 10.1016/j.neuropsychologia.2008.08.008)
Butler, S.H., Rossit, S., Gilchrist, I.D., Ludwig, C.J.H., Olk, B., Muir, K. , Reeves, I. and Harvey, M. (2009) Non-lateralised deficits in anti-saccade performance in patients with hemispatial neglect. Neuropsychologia, 47(12), pp. 2488-2495. (doi: 10.1016/j.neuropsychologia.2009.04.022)
Dowson, A. et al. (2009) Response to Letter Regarding Article, 'Migraine Intervention With STARFlex Technology (MIST) Trial'. Circulation, 119(5), E194-E194.
Kidwell, C.S., Lees, K.R., Muir, K.W. , Chen, C., Davis, S.M., De Silva, D.A., Weir, C.J., Starkman, S., Alger, J.R. and Saver, J.L. (2009) Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial. Stroke, 40(5), pp. 1704-1709. (doi: 10.1161/STROKEAHA.108.537613)
Rossit, S. et al. (2009) No neglect- specific deficits in reaching tasks. Cerebral Cortex, 19(11), pp. 2616-2624. (doi: 10.1093/cercor/bhp016) (PMID:19282456)
Schonewille, W. et al. (2009) Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurology, 8(8), pp. 724-730.
2008
Santosh, C. et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28(10), pp. 1742-1753. (doi: 10.1038/jcbfm.2008.56)
Lecrux, C., McCabe, C. , Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K. , Lees, K.R. and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39(2), pp. 448-454. (doi: 10.1161/STROKEAHA.107.492934)
Dani, K.A., McCormick, M.T. and Muir, K.W. (2008) Brain lesion volume and capacity for consent in stroke trials: potential regulatory barriers to the use of surrogate markers. Stroke, 39(8), pp. 2336-2340. (doi: 10.1161/STROKEAHA.107.507111)
Davis, S. et al. (2008) Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurology, 7(4), pp. 299-309. (doi: 10.1016/S1474-4422(08)70044-9)
Dowson, A. et al. (2008) Migraine intervention with STARFlex technology (MIST) trial - A prospective, multicenter, double-blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine. Circulation, 117(11), pp. 1397-1404.
Lees, K.R. et al. (2008) Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register. QJM: An International Journal of Medicine, 101(11), pp. 863-869. (doi: 10.1093/qjmed/hcn102)
McCormick, M.T., Muir, K.W. , Gray, C.S. and Walters, M.R. (2008) Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke, 39(7), pp. 2177-2185. (doi: 10.1161/STROKEAHA.107.496646)
McCormick, M.T., Reeves, I., Baird, T., Bone, I. and Muir, K. (2008) Implementation of a stroke thrombolysis service within a tertiary neurosciences centre in the United Kingdom. QJM: An International Journal of Medicine, 101(4), pp. 291-298.
Muir, K.W. (2008) The PREVAIL trial and low-molecular-weight heparin for prevention of venous thromboembolism. Stroke, 39(7), pp. 2174-2176. (doi: 10.1161/STROKEAHA.107.509588)
Wahlgren, N., Ahmed, N., Davalos, A., Hacke, W., Millan, M., Muir, K. , Roine, R.O., Toni, D. and Lees, K.R. (2008) Thrombolysis with alteplase 3—4·5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet, 372(9646), pp. 1303-1309. (doi: 10.1016/S0140-6736(08)61339-2)
2007
Smith, A., Gilchrist, L.D., Butler, S.H., Muir, K., Bone, I., Reeves, I. and Harvey, M. (2007) Non-lateralised deficits of drawing production in hemispatial neglect. Brain and Cognition, 64(2), pp. 150-157. (doi: 10.1016/j.bandc.2007.02.001)
Aslanyan, S., Weir, C.J., Muir, K.W. and Lees, K.R. (2007) Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial. Stroke, 38(10), pp. 1269-1273. (doi: 10.1161/01.STR.0000259628.94421.09)
Moreton, F.C., McCormick, M. and Muir, K.W. (2007) Insular cortex hypoperfusion and acute phase blood glucose after stroke: a CT perfusion study. Stroke, 38(2), pp. 407-410. (doi: 10.1161/01.STR.0000254487.73282.4d)
Muir, K.W. , Baird-Gunning, J., Walker, L., Baird, T., McCormick, M. and Coutts, S.B. (2007) Can the ischemic penumbra be identified on noncontrast CT of acute stroke? Stroke, 38(9), pp. 2485-2490. (doi: 10.1161/STROKEAHA.107.484592)
Muir, K. , Sattar, N. , Tyrrell, P. and Warburton, E. (2007) Inflammation and ischaemic stroke. Current Opinion in Neurology, 20, pp. 334-342.
Murray, S., Bashir, K., Lees, K.R., Langhorne, P., Muir, K., MacAlpine, C. and Roberts, M. (2007) Epidemiological aspects of referral to TIA clinics in Glasgow. Scottish Medical Journal, 52, pp. 4-8.
2006
McCormick, M.T. and Muir, K.W. (2006) Referral bias may underestimate number of very elderly patients eligible for rtPA. Stroke, 37(4), pp. 942-943. (doi: 10.1161/01.STR.0000210167.37729.eb)
Baird, T.A., Halbert, H.M., McCormick, M., Muir, K.W. and Teasdale, E. (2006) Visual evaluation of perfusion computed tomography in acute stroke accurately estimates infarct volume and tissue viability. Journal of Neurology, Neurosurgery and Psychiatry, 77, pp. 334-339. (doi: 10.1136/jnnp.2005.074179)
Baron, J., Buchan, A., Muir, K. , Rother, J. and von, K. (2006) Imaging of acute stroke. Lancet Neurology, 5, pp. 755-768.
Butler, S.H., Gilchrist, I.D., Ludwig, C.J.H., Muir, K. and Harvey, M. (2006) Impairments of oculomotor control in a patient with a right temporo-parietal lesion. Cognitive Neuropsychology, 23(6), pp. 990-999. (doi: 10.1080/13594320600768847)
Lees, K., Muir, K. , Ovbiagele, B., Saver, J. and Weir, C. (2006) Effect of smoking status on outcome after acute ischemic stroke. Cerebrovascular Diseases, 21, pp. 260-265. (doi: 10.1159/000091224)
Muir, K. , Razvi, S., Teasdale, E., Tyagi, A. and Walker, L. (2006) Cluster headache due to internal carotid artery dissection. Journal of Neurology, 253(5), pp. 661-663.
Muir, K. (2006) Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Current Opinion in Pharmacology, 6, pp. 53-60. (doi: 10.1016/j.coph.2005.12.002)
2005
Bone, I., Davidson, R., Muir, K. and Razvi, S.S.M. (2005) The prevalence of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) in the west of Scotland. Journal of Neurology, Neurosurgery and Psychiatry, 76(5), pp. 739-741.
Muir, K.W. and Santosh, C. (2005) Imaging of acute stroke and transient ischaemic attack. Journal of Neurology, Neurosurgery and Psychiatry, 76, pp. 19-28. (doi: 10.1136/jnnp.2005.075168)
Muir, K. and Teal, P. (2005) Why have neuroprotectants failed? Lessons learned from stroke trials. Journal of Neurology, 252, pp. 1011-1020. (doi: 10.1007/s00415-005-0933-6)
Razvi, S., Davidson, R., Bone, I. and Muir, K. (2005) Is inadequate family history a barrier to diagnosis in CADASIL? Acta Neurologica Scandinavica, 112, pp. 323-326. (doi: 10.1111/j.1600-0404.2005.00495.x)
Walters, M., Muir, K., Harbison, J., Lees, K. and Ford, G. (2005) Intravenous thrombolysis for acute ischaemic stroke: Preliminary experience with recombinant tissue plasminogen activator in the UK. Cerebrovascular Diseases, 20, pp. 438-442. (doi: 10.1159/000088982)
2004
Baird, T., Bone, I. and Muir, K. (2004) Basilar artery occlusion. Neurocritical Care, 1(3), pp. 319-329.
Lees, K.R. et al. (2004) Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet, 363, pp. 439-445.
McGonigal, A. and Muir, K. (2004) Journey of an embolus. Neurology, 62(10), p. 1902.
Muir, K. (2004) Secondary prevention for stroke and transient ischaemic attacks - Even patients with normal blood pressure and cholesterol levels may benefit. British Medical Journal, 328(7435), pp. 297-298.
Muir, K. (2004) Secondary prevention for stroke and transient ischaemic attacks - Horizons needs expanding - PROGRESS is about reducing blood pressure, not promoting drugs - Author's reply. British Medical Journal, 328(7444), p. 897.
Muir, K. and Nazir, F. (2004) Prolonged interval between vertebral artery dissection and ischemic stroke. Neurology, 62(9), pp. 1646-1647.
2003
Al, D.L. et al. (2003) Cluster-randomized, controlled trial of computer-based decision support for selecting long-term anti-thrombotic therapy after acute ischaemic stroke. QJM: An International Journal of Medicine, 96, pp. 143-153. (doi: 10.1093/qjmed/hcg019)
Alberts, M., Graffagnino, C., Hoffmann, K., Lees, K., McCarron, M., Muir, K. , Nicoll, J. and Weir, C. (2003) Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurologica Scandinavica, 107, pp. 106-109.
Muir, K. and Lees, K. (2003) Excitatory Amino Acid antagonists for acute stroke. Cochrane Database of Systematic Reviews, 3, CD001244.
2002
Muir, K. (2002) Heterogeneity of stroke pathophysiology and neuroprotective clinical trial design. Stroke, 33(6), pp. 1545-1550.
Muir, K. (2002) Inflammation, blood pressure, and stroke: An opportunity to target primary prevention? Stroke, 33(12), pp. 2732-2733.
Muir, K. (2002) Magnesium in stroke treatment. Postgraduate Medical Journal, 78, pp. 641-645.
Wilson, J., Hareendran, A., Grant, M., Baird, T., Schulz, U., Muir, K. and Bone, I. (2002) Improving the assessment of outcomes in stroke - Use of a structured interview to assign grades on the modified Rankin Scale. Stroke, 33, pp. 2243-2246. (doi: 10.1161/01STR000002743722450BD)
2001
Bone, I., Dyker, A., Lees, K., McCarron, M., Muir, K. , Nicoll, J. and Weir, C. (2001) Apolipoprotein E genotype, coagulation, and survival following acute stroke. Neurology, 57(6), pp. 1097-1100.
Muir, K. (2001) Headache after diagnostic lumbar puncture - Authors should have used smaller gauge needles - Reply. British Medical Journal, 322(7292), p. 994.
Muir, K. (2001) Medical management of stroke. Journal of Neurology, Neurosurgery and Psychiatry, 70, I12-I16.
Muir, K.W. (2001) Magnesium for neuroprotection in ischaemic stroke - Rationale for use and evidence of effectiveness. CNS Drugs, 15, pp. 921-930.
2000
Muir, K.W. , Watt, A., Baxter, G., Grosset, D.G. and Lees, K.R. (2000) Randomized trial of graded compression stockings for prevention of deep-vein thrombosis after acute stroke. QJM: An International Journal of Medicine, 93(6), pp. 359-364. (doi: 10.1093/qjmed/93.6.359) (PMID:10873185)
McCarron, M., Metcalfe, R. and Muir, K. (2000) Facial nerve palsy secondary to internal carotid artery dissection. European Journal of Neurology, 7(6), pp. 723-725.
1999
Muir, K. W. and Grosset, D. G. (1999) Using pathophysiology in acute stroke trials: Authors' response. Stroke, 30(6), p. 1293. (doi: 10.1161/01.STR.30.6.1293)
Muir, K. W. and Grosset, D. G. (1999) Neuroprotection for acute stroke: making clinical trials work. Stroke, 30(1), pp. 180-182. (doi: 10.1161/01.STR.30.1.180) (PMID:9880407)
1997
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1997) Effects of prolonged infusions of the NMDA antagonist aptiganel hydrochloride (CNS 1102) in normal volunteers. Clinical Neuropharmacology, 20(4), pp. 311-321. (doi: 10.1097/00002826-199708000-00003) (PMID:9260729)
1996
Muir, K.W. , McNeish, I. , Grosset, D.G. and Metcalfe, M. (1996) Visualization of cardiac emboli from mitral valve papillary fibroelastoma. Stroke, 27(6), pp. 1133-1134. (PMID:8650729)
1995
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in man. Annals of the New York Academy of Sciences, 765(1), pp. 336-337. (doi: 10.1111/j.1749-6632.1995.tb16609.x) (PMID:7486638)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in volunteers. Annals of the New York Academy of Sciences, 765(1), pp. 279-289. (doi: 10.1111/j.1749-6632.1995.tb16585.x) (PMID:7486614)
Grosset, D. , Muir, K. and Lees, K. (1995) Systemic and cerebral hemodynamic responses to the noncompetitive N-methyl-D-aspartate (NMDA) antagonist CNS 1102. Journal of Cardiovascular Pharmacology, 25(5), pp. 705-709. (doi: 10.1097/00005344-199505000-00004) (PMID:7630148)
1994
Weir, C.J., Lees, K.R., Muir, K.W. , Grosset, D.G. and Murray, G.D. (1994) Stroke scoring systems: Author's reply. Lancet, 344(8939-4), p. 1781. (doi: 10.1016/S0140-6736(94)92923-8)
Weir, C.J., Murray, G.D., Adams, F.G., Muir, K.W. , Grosset, D.G. and Lees, K.R. (1994) Poor accuracy of stroke scoring systems for differential clinical diagnosis of intracranial haemorrhage and infarction. Lancet, 344(8928), pp. 999-1002. (doi: 10.1016/S0140-6736(94)91648-9) (PMID:7934437)
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Huang, X., Moreton, F., Kalladka, D., Cheripelli, B. K., Macisaac, R., Tait, R. C. and Muir, K. (2015) Coagulation and fibrinolytic activity of tenecteplase and alteplase in acute ischemic stroke. Stroke, 46(12), pp. 3543-3546. (doi: 10.1161/strokeaha.115.011290) (PMID:26514192)
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Urfer, R., Moebius, H. J., Skoloudik, D., Santamarina, E., Sato, W., Mita, S. and Muir, K. W. (2014) Phase II trial of the sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke. Stroke, 45(11), pp. 3304-3310. (doi: 10.1161/STROKEAHA.114.005835) (PMID:25270629)
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Moreton, F., Razvi, S., Davidson, R. and Muir, K. (2014) Changing clinical patterns and increasing prevalence in CADASIL. Acta Neurologica Scandinavica, 130(3), pp. 197-203. (doi: 10.1111/ane.12266)
Robertson, C. A., McCabe, C. , Lopez-Gonzalez, M. R., Deuchar, G. A., Dani, K., Holmes, W. M. , Muir, K. W. , Santosh, C. and Macrae, I. M. (2014) Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. International Journal of Stroke, 10(1), pp. 42-50. (doi: 10.1111/ijs.12327)
Savitz, S. I. et al. (2014) Stem cells as an emerging paradigm in Stroke 3: enhancing the development of clinical trials. Stroke, 45(2), pp. 634-639. (doi: 10.1161/STROKEAHA.113.003379)
Hill, M. and Muir, K.W. (2013) INTERACT-2: should blood pressure be aggressively lowered acutely after intracerebral hemorrhage? Stroke, 44(10), pp. 2951-2952. (doi: 10.1161/STROKEAHA.113.002790)
Muir, K.W. (2013) STICH 2: does decompression have a role in superficial intracerebral hematoma? International Journal of Stroke, 8(7), pp. 540-541. (doi: 10.1111/ijs.12182)
Brazzelli, M., Shuler, K., Quayyum, Z., Hadley, D., Muir, K. , McNamee, P., De Wilde, J., Dennis, M., Sandercock, P. and Wardlaw, J. M. (2013) Clinical and imaging services for TIA and minor stroke: results of two surveys of practice across the UK. BMJ Open, 3(8), e003359. (doi: 10.1136/bmjopen-2013-003359)
Scalzo, F. et al. (2013) Multi-center prediction of hemorrhagic transformation in acute ischemic stroke using permeability imaging features. Magnetic Resonance Imaging, 31(6), pp. 961-969. (doi: 10.1016/j.mri.2013.03.013)
Rossit, R., Olsen, L., Butler, S., Muir, K. and Harvey, M. (2013) The neural basis of reflexive and volitional saccades: evidence from lesion-symptom mapping with stroke patients. Behavioural Neurology, 27(3), pp. 388-389. (doi: 10.3233/BEN-139900)
Tarr, D., Graham, D. , Roy, L.A., Holmes, W.M. , McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi: 10.1038/jcbfm.2013.107)
van der Hoeven, E.J.R.J. et al. (2013) The Basilar artery international cooperation study (BASICS): study protocol for a randomised controlled trial. Trials, 14(200), (doi: 10.1186/1745-6215-14-200)
Wintermark, M. et al. (2013) Acute stroke imaging research roadmap II. Stroke, 44(9), pp. 2628-2639. (doi: 10.1161/STROKEAHA.113.002015)
Dani, K.A., Santosh, C., Brennan, D., Hadley, D.M. and Muir, K.W. (2012) Crossed cerebellar diaschisis: insights into oxygen challenge MRI. Journal of Cerebral Blood Flow and Metabolism, 32(12), pp. 2114-2117. (doi: 10.1038/jcbfm.2012.142)
Muir, K.W. (2012) Imaging and treatment response after ischaemic stroke. Lancet Neurology, 11(10), pp. 838-839. (doi: 10.1016/S1474-4422(12)70207-7)
Sinden, J.D. and Muir, K.W. (2012) Stem cells in stroke treatment: the promise and the challenges. International Journal of Stroke, 7(5), pp. 426-434. (doi: 10.1111/j.1747-4949.2012.00840.x)
Rossit, S., McIntosh, R.D., Malhotra, P., Butler, S.H., Muir, K. and Harvey, M. (2012) Attention in action: evidence from on-line corrections in left visual neglect. Neuropsychologia, 50(6), pp. 1124-1135. (doi: 10.1016/j.neuropsychologia.2011.10.004)
Cooper, S.A., Joshi, A.C., Seenan, P.J., Hadley, D.M., Muir, K.W. , Leigh, R.J. and Metcalfe, R.A. (2012) Akinetopsia: acute presentation and evidence for persisting defects in motion vision. Journal of Neurology, Neurosurgery and Psychiatry, 83(2), pp. 229-230. (doi: 10.1136/jnnp.2010.223727)
Dani, K.A., Thomas, R.G.R., Chappell, F.M., Shuler, K., Muir, K.W. and Wardlaw, J.M. (2012) Systematic review of perfusion imaging with computed tomography and magnetic resonance in acute ischemic stroke: heterogeneity of acquisition and postprocessing parameters: a translational medicine research collaboration multicentre acute stroke imaging study. Stroke, 43(2), pp. 563-566. (doi: 10.1161/STROKEAHA.111.629923)
McVerry, F., Liebeskind, D.S. and Muir, K.W. (2012) Systematic review of methods for assessing leptomeningeal collateral flow. American Journal of Neuroradiology, 33(3), pp. 576-582. (doi: 10.3174/ajnr.A2794)
Rossit, S., Malhotra, P., Muir, K. , Reeves, I., Duncan, G. and Harvey, M. (2011) The role of right temporal lobe structures in off-line action: evidence from lesion-behavior mapping in stroke patients. Cerebral Cortex, 21(12), pp. 2751-2761. (doi: 10.1093/cercor/bhr073)
Dani, K.A., Thomas, R.G.R., Chappell, F.M., Shuler, K., MacLeod, M.J., Muir, K.W. and Wardlaw, J.M. (2011) Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds. Annals of Neurology, 70(3), pp. 384-401. (doi: 10.1002/ana.22500)
Kalladka, D. and Muir, K.W. (2011) Stem cell therapy in stroke: designing clinical trials. Neurochemistry International, 59(3), pp. 367-370. (doi: 10.1016/j.neuint.2011.03.016)
Robertson, C. A., McCabe, C. , Gallagher, L., Lopez Gonzalez, M. d., Holmes, W. M. , Condon, B., Muir, K. W. , Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1788-1798. (doi: 10.1038/jcbfm.2011.67)
Robertson, C. A., McCabe, C. , Gallagher, L., Lopez-Gonzalez, M. d., Holmes, W. M. , Condon, B., Muir, K. W. , Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31, pp. 1778-1787. (doi: 10.1038/jcbfm.2011.66)
MacDougall, N.J.J., McVerry, F., Baird, S., Baird, T., Teasdale, E. and Muir, K.W. (2011) Iodinated contrast media and cerebral hemorrhage after intravenous thrombolysis. Stroke, 42(8), pp. 2170-2174. (doi: 10.1161/STROKEAHA.111.618777)
Harvey, M. et al. (2011) Long term improvements in activities of daily living in patients with hemispatial neglect. Behavioural Neurology, 23(4), pp. 237-239. (doi: 10.3233/BEN-2010-0304)
MacDougall, N.J.J. and Muir, K. (2011) Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis. Journal of Cerebral Blood Flow and Metabolism, 31(3), pp. 807-818. (doi: 10.1038/jcbfm.2010.210)
Muir, K.W. , Sinden, J., Miljan, E. and Dunn, L. (2011) Intracranial delivery of stem cells. Translational Stroke Research, 2(3), pp. 266-271. (doi: 10.1007/s12975-011-0095-z)
Nagakane, Y. et al. (2011) EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration. Stroke, 42(1), pp. 59-64. (doi: 10.1161/STROKEAHA.110.580464)
Puetz, V. et al. (2011) Extent of hypoattenuation on CT angiography source images in Basilar Artery occlusion: prognostic value in the Basilar Artery International Cooperation Study. Stroke, 42(12), pp. 3454-3459. (doi: 10.1161/STROKEAHA.111.622175)
Dani, K. A., Santosh, C., Brennan, D., McCabe, C. , Holmes, W. M. , Condon, B., Hadley, D. M., Macrae, I. M., Shaw, M. and Muir, K. W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68(1), pp. 37-47. (doi: 10.1002/ana.22032)
Crozier, J. E. M., Reid, J., Welch, G., Muir, K.W. and Stuart, W. (2010) Early carotid endarterectomy following thrombolysis in the hyperacute treatment of stroke. British Journal of Surgery, 98(2), pp. 235-238. (doi: 10.1002/bjs.7306)
Awadh, M., MacDougall, N., Santosh, C., Teasdale, E., Baird, T. and Muir, K.W. (2010) Early recurrent ischemic stroke complicating intravenous thrombolysis for stroke: incidence and association with atrial fibrillation. Stroke, 41(9), pp. 1990-1995. (doi: 10.1161/STROKEAHA.109.569459)
Dani, K.A. and Muir, K.W. (2010) Do iodinated contrast agents impair fibrinolysis in acute stroke? A systematic review. American Journal of Neuroradiology, 31(1), pp. 170-174. (doi: 10.3174/ajnr.A1782)
McCormick, M., Hadley, D., McLean, J. R., Macfarlane, J. A., Condon, B. and Muir, K. W. (2010) Randomized, Controlled Trial of Insulin for Acute Poststroke Hyperglycemia. Annals of Neurology, 67(5), pp. 570-578. (doi: 10.1002/ana.21983)
Rossit, S., Malhotra, P., Muir, K. , Reeves, I., Duncan, G., Birschel, P. and Harvey, M. (2009) The neural basis of visuomotor deficits in hemispatial neglect. Neuropsychologia, 47(10), pp. 2149-2153. (doi: 10.1016/j.neuropsychologia.2009.04.015)
Rossit, S., Muir, K. , Reeves, I., Duncan, G., Birschel, P. and Harvey, M. (2009) Immediate and delayed reaching in hemispatial neglect. Neuropsychologia, 47(6), pp. 1563-1572. (doi: 10.1016/j.neuropsychologia.2008.08.008)
Butler, S.H., Rossit, S., Gilchrist, I.D., Ludwig, C.J.H., Olk, B., Muir, K. , Reeves, I. and Harvey, M. (2009) Non-lateralised deficits in anti-saccade performance in patients with hemispatial neglect. Neuropsychologia, 47(12), pp. 2488-2495. (doi: 10.1016/j.neuropsychologia.2009.04.022)
Dowson, A. et al. (2009) Response to Letter Regarding Article, 'Migraine Intervention With STARFlex Technology (MIST) Trial'. Circulation, 119(5), E194-E194.
Kidwell, C.S., Lees, K.R., Muir, K.W. , Chen, C., Davis, S.M., De Silva, D.A., Weir, C.J., Starkman, S., Alger, J.R. and Saver, J.L. (2009) Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial. Stroke, 40(5), pp. 1704-1709. (doi: 10.1161/STROKEAHA.108.537613)
Rossit, S. et al. (2009) No neglect- specific deficits in reaching tasks. Cerebral Cortex, 19(11), pp. 2616-2624. (doi: 10.1093/cercor/bhp016) (PMID:19282456)
Schonewille, W. et al. (2009) Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurology, 8(8), pp. 724-730.
Santosh, C. et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28(10), pp. 1742-1753. (doi: 10.1038/jcbfm.2008.56)
Lecrux, C., McCabe, C. , Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K. , Lees, K.R. and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39(2), pp. 448-454. (doi: 10.1161/STROKEAHA.107.492934)
Dani, K.A., McCormick, M.T. and Muir, K.W. (2008) Brain lesion volume and capacity for consent in stroke trials: potential regulatory barriers to the use of surrogate markers. Stroke, 39(8), pp. 2336-2340. (doi: 10.1161/STROKEAHA.107.507111)
Davis, S. et al. (2008) Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurology, 7(4), pp. 299-309. (doi: 10.1016/S1474-4422(08)70044-9)
Dowson, A. et al. (2008) Migraine intervention with STARFlex technology (MIST) trial - A prospective, multicenter, double-blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine. Circulation, 117(11), pp. 1397-1404.
Lees, K.R. et al. (2008) Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register. QJM: An International Journal of Medicine, 101(11), pp. 863-869. (doi: 10.1093/qjmed/hcn102)
McCormick, M.T., Muir, K.W. , Gray, C.S. and Walters, M.R. (2008) Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke, 39(7), pp. 2177-2185. (doi: 10.1161/STROKEAHA.107.496646)
McCormick, M.T., Reeves, I., Baird, T., Bone, I. and Muir, K. (2008) Implementation of a stroke thrombolysis service within a tertiary neurosciences centre in the United Kingdom. QJM: An International Journal of Medicine, 101(4), pp. 291-298.
Muir, K.W. (2008) The PREVAIL trial and low-molecular-weight heparin for prevention of venous thromboembolism. Stroke, 39(7), pp. 2174-2176. (doi: 10.1161/STROKEAHA.107.509588)
Wahlgren, N., Ahmed, N., Davalos, A., Hacke, W., Millan, M., Muir, K. , Roine, R.O., Toni, D. and Lees, K.R. (2008) Thrombolysis with alteplase 3—4·5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet, 372(9646), pp. 1303-1309. (doi: 10.1016/S0140-6736(08)61339-2)
Smith, A., Gilchrist, L.D., Butler, S.H., Muir, K., Bone, I., Reeves, I. and Harvey, M. (2007) Non-lateralised deficits of drawing production in hemispatial neglect. Brain and Cognition, 64(2), pp. 150-157. (doi: 10.1016/j.bandc.2007.02.001)
Aslanyan, S., Weir, C.J., Muir, K.W. and Lees, K.R. (2007) Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial. Stroke, 38(10), pp. 1269-1273. (doi: 10.1161/01.STR.0000259628.94421.09)
Moreton, F.C., McCormick, M. and Muir, K.W. (2007) Insular cortex hypoperfusion and acute phase blood glucose after stroke: a CT perfusion study. Stroke, 38(2), pp. 407-410. (doi: 10.1161/01.STR.0000254487.73282.4d)
Muir, K.W. , Baird-Gunning, J., Walker, L., Baird, T., McCormick, M. and Coutts, S.B. (2007) Can the ischemic penumbra be identified on noncontrast CT of acute stroke? Stroke, 38(9), pp. 2485-2490. (doi: 10.1161/STROKEAHA.107.484592)
Muir, K. , Sattar, N. , Tyrrell, P. and Warburton, E. (2007) Inflammation and ischaemic stroke. Current Opinion in Neurology, 20, pp. 334-342.
Murray, S., Bashir, K., Lees, K.R., Langhorne, P., Muir, K., MacAlpine, C. and Roberts, M. (2007) Epidemiological aspects of referral to TIA clinics in Glasgow. Scottish Medical Journal, 52, pp. 4-8.
McCormick, M.T. and Muir, K.W. (2006) Referral bias may underestimate number of very elderly patients eligible for rtPA. Stroke, 37(4), pp. 942-943. (doi: 10.1161/01.STR.0000210167.37729.eb)
Baird, T.A., Halbert, H.M., McCormick, M., Muir, K.W. and Teasdale, E. (2006) Visual evaluation of perfusion computed tomography in acute stroke accurately estimates infarct volume and tissue viability. Journal of Neurology, Neurosurgery and Psychiatry, 77, pp. 334-339. (doi: 10.1136/jnnp.2005.074179)
Baron, J., Buchan, A., Muir, K. , Rother, J. and von, K. (2006) Imaging of acute stroke. Lancet Neurology, 5, pp. 755-768.
Butler, S.H., Gilchrist, I.D., Ludwig, C.J.H., Muir, K. and Harvey, M. (2006) Impairments of oculomotor control in a patient with a right temporo-parietal lesion. Cognitive Neuropsychology, 23(6), pp. 990-999. (doi: 10.1080/13594320600768847)
Lees, K., Muir, K. , Ovbiagele, B., Saver, J. and Weir, C. (2006) Effect of smoking status on outcome after acute ischemic stroke. Cerebrovascular Diseases, 21, pp. 260-265. (doi: 10.1159/000091224)
Muir, K. , Razvi, S., Teasdale, E., Tyagi, A. and Walker, L. (2006) Cluster headache due to internal carotid artery dissection. Journal of Neurology, 253(5), pp. 661-663.
Muir, K. (2006) Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Current Opinion in Pharmacology, 6, pp. 53-60. (doi: 10.1016/j.coph.2005.12.002)
Bone, I., Davidson, R., Muir, K. and Razvi, S.S.M. (2005) The prevalence of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) in the west of Scotland. Journal of Neurology, Neurosurgery and Psychiatry, 76(5), pp. 739-741.
Muir, K.W. and Santosh, C. (2005) Imaging of acute stroke and transient ischaemic attack. Journal of Neurology, Neurosurgery and Psychiatry, 76, pp. 19-28. (doi: 10.1136/jnnp.2005.075168)
Muir, K. and Teal, P. (2005) Why have neuroprotectants failed? Lessons learned from stroke trials. Journal of Neurology, 252, pp. 1011-1020. (doi: 10.1007/s00415-005-0933-6)
Razvi, S., Davidson, R., Bone, I. and Muir, K. (2005) Is inadequate family history a barrier to diagnosis in CADASIL? Acta Neurologica Scandinavica, 112, pp. 323-326. (doi: 10.1111/j.1600-0404.2005.00495.x)
Walters, M., Muir, K., Harbison, J., Lees, K. and Ford, G. (2005) Intravenous thrombolysis for acute ischaemic stroke: Preliminary experience with recombinant tissue plasminogen activator in the UK. Cerebrovascular Diseases, 20, pp. 438-442. (doi: 10.1159/000088982)
Baird, T., Bone, I. and Muir, K. (2004) Basilar artery occlusion. Neurocritical Care, 1(3), pp. 319-329.
Lees, K.R. et al. (2004) Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet, 363, pp. 439-445.
McGonigal, A. and Muir, K. (2004) Journey of an embolus. Neurology, 62(10), p. 1902.
Muir, K. (2004) Secondary prevention for stroke and transient ischaemic attacks - Even patients with normal blood pressure and cholesterol levels may benefit. British Medical Journal, 328(7435), pp. 297-298.
Muir, K. (2004) Secondary prevention for stroke and transient ischaemic attacks - Horizons needs expanding - PROGRESS is about reducing blood pressure, not promoting drugs - Author's reply. British Medical Journal, 328(7444), p. 897.
Muir, K. and Nazir, F. (2004) Prolonged interval between vertebral artery dissection and ischemic stroke. Neurology, 62(9), pp. 1646-1647.
Al, D.L. et al. (2003) Cluster-randomized, controlled trial of computer-based decision support for selecting long-term anti-thrombotic therapy after acute ischaemic stroke. QJM: An International Journal of Medicine, 96, pp. 143-153. (doi: 10.1093/qjmed/hcg019)
Alberts, M., Graffagnino, C., Hoffmann, K., Lees, K., McCarron, M., Muir, K. , Nicoll, J. and Weir, C. (2003) Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurologica Scandinavica, 107, pp. 106-109.
Muir, K. and Lees, K. (2003) Excitatory Amino Acid antagonists for acute stroke. Cochrane Database of Systematic Reviews, 3, CD001244.
Muir, K. (2002) Heterogeneity of stroke pathophysiology and neuroprotective clinical trial design. Stroke, 33(6), pp. 1545-1550.
Muir, K. (2002) Inflammation, blood pressure, and stroke: An opportunity to target primary prevention? Stroke, 33(12), pp. 2732-2733.
Muir, K. (2002) Magnesium in stroke treatment. Postgraduate Medical Journal, 78, pp. 641-645.
Wilson, J., Hareendran, A., Grant, M., Baird, T., Schulz, U., Muir, K. and Bone, I. (2002) Improving the assessment of outcomes in stroke - Use of a structured interview to assign grades on the modified Rankin Scale. Stroke, 33, pp. 2243-2246. (doi: 10.1161/01STR000002743722450BD)
Bone, I., Dyker, A., Lees, K., McCarron, M., Muir, K. , Nicoll, J. and Weir, C. (2001) Apolipoprotein E genotype, coagulation, and survival following acute stroke. Neurology, 57(6), pp. 1097-1100.
Muir, K. (2001) Headache after diagnostic lumbar puncture - Authors should have used smaller gauge needles - Reply. British Medical Journal, 322(7292), p. 994.
Muir, K. (2001) Medical management of stroke. Journal of Neurology, Neurosurgery and Psychiatry, 70, I12-I16.
Muir, K.W. (2001) Magnesium for neuroprotection in ischaemic stroke - Rationale for use and evidence of effectiveness. CNS Drugs, 15, pp. 921-930.
Muir, K.W. , Watt, A., Baxter, G., Grosset, D.G. and Lees, K.R. (2000) Randomized trial of graded compression stockings for prevention of deep-vein thrombosis after acute stroke. QJM: An International Journal of Medicine, 93(6), pp. 359-364. (doi: 10.1093/qjmed/93.6.359) (PMID:10873185)
McCarron, M., Metcalfe, R. and Muir, K. (2000) Facial nerve palsy secondary to internal carotid artery dissection. European Journal of Neurology, 7(6), pp. 723-725.
Muir, K. W. and Grosset, D. G. (1999) Using pathophysiology in acute stroke trials: Authors' response. Stroke, 30(6), p. 1293. (doi: 10.1161/01.STR.30.6.1293)
Muir, K. W. and Grosset, D. G. (1999) Neuroprotection for acute stroke: making clinical trials work. Stroke, 30(1), pp. 180-182. (doi: 10.1161/01.STR.30.1.180) (PMID:9880407)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1997) Effects of prolonged infusions of the NMDA antagonist aptiganel hydrochloride (CNS 1102) in normal volunteers. Clinical Neuropharmacology, 20(4), pp. 311-321. (doi: 10.1097/00002826-199708000-00003) (PMID:9260729)
Muir, K.W. , McNeish, I. , Grosset, D.G. and Metcalfe, M. (1996) Visualization of cardiac emboli from mitral valve papillary fibroelastoma. Stroke, 27(6), pp. 1133-1134. (PMID:8650729)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in man. Annals of the New York Academy of Sciences, 765(1), pp. 336-337. (doi: 10.1111/j.1749-6632.1995.tb16609.x) (PMID:7486638)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in volunteers. Annals of the New York Academy of Sciences, 765(1), pp. 279-289. (doi: 10.1111/j.1749-6632.1995.tb16585.x) (PMID:7486614)
Grosset, D. , Muir, K. and Lees, K. (1995) Systemic and cerebral hemodynamic responses to the noncompetitive N-methyl-D-aspartate (NMDA) antagonist CNS 1102. Journal of Cardiovascular Pharmacology, 25(5), pp. 705-709. (doi: 10.1097/00005344-199505000-00004) (PMID:7630148)
Weir, C.J., Lees, K.R., Muir, K.W. , Grosset, D.G. and Murray, G.D. (1994) Stroke scoring systems: Author's reply. Lancet, 344(8939-4), p. 1781. (doi: 10.1016/S0140-6736(94)92923-8)
Weir, C.J., Murray, G.D., Adams, F.G., Muir, K.W. , Grosset, D.G. and Lees, K.R. (1994) Poor accuracy of stroke scoring systems for differential clinical diagnosis of intracranial haemorrhage and infarction. Lancet, 344(8928), pp. 999-1002. (doi: 10.1016/S0140-6736(94)91648-9) (PMID:7934437)
Muir, K.W. , Grosset, D.G. , Gamzu, E. and Lees, K.R. (1994) Pharmacological effects of the non‐competitive NMDA antagonist CNS 1102 in normal volunteers. British Journal of Clinical Pharmacology, 38(1), pp. 33-38. (doi: 10.1111/j.1365-2125.1994.tb04318.x) (PMID:7946934) (PMCID:PMC1364834)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1994) Interconversion of stroke scales: implications for therapeutic trials. Stroke, 25(7), pp. 1366-1370. (doi: 10.1161/01.STR.25.7.1366) (PMID:8023351)
Book Sections
Muir, K. W. and Sinden, J. D. (2015) The CTX Human Neural Stem Cell Line and the PISCES Stroke Trial. In: Hess, D. C. (ed.) Cell Therapy for Brain Injury. Springer, pp. 111-128. ISBN 9783319150628 (doi: 10.1007/978-3-319-15063-5_8)
Rodie, M. E., Forbes, K. P. and Muir, K. (2014) Advances in neuroimaging. In: Hiort, O. and Ahmed, S.F. (eds.) Understanding Differences and Disorders of Sex Development (DSD). Series: Endocrine development (27). Karger: Basel, pp. 63-75. ISBN 9783318025583 (doi: 10.1159/000363628)
Conference or Workshop Item
Ding, B., Ghosalkar, J., Williams, S. , Forbes, K., Woodward, R., Dragonu, I., Porter, D., Muir, K. and Foo, S. Y. (2023) Vessel Wall Imaging at 7 Tesla Using 3D Turbo Spin-echo. SINAPSE Annual Scientific Meeting 2023, Glasgow, UK, 14 June 2023.
Harvey, M. , Muir, K. , Benwell, C., Walters, M. and Learmonth, G. (2019) Feasibility of Applying Non-invasive Brain Stimulation to Induce Recovery from Neglect. 5th European Stroke Organisation Conference (ESOC 2019), Milan, Italy, 22-24 May 2019.
Learmonth, G. , Muir, K.W. , Benwell, C., Walters, M. and Harvey, M. (2018) Recruitment Issues with Non-invasive Brain Stimulation in Stroke Patients. UK Stroke Forum 2018, Telford, UK, 4-6 Dec 2018. (doi: 10.1177/1747493018801108)
Learmonth, G. , Benwell, C.S.Y., Walters, M. , Muir, K. and Harvey, M. (2017) Feasibility of Multi-Session tDCS in Rehabilitating Post-Stroke Hemispatial Neglect. 2nd International Congress on NeuroRehabilitation and Neural Repair, Maastricht, The Netherlands, 22-24 May 2017.
Heggie, R., Wu, O. , White, P., Ford, G. A., Wardlaw, J., Brown, M. M., Clifton, A. and Muir, K. W. (2017) Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Cost-Effectiveness and Value of Implementation Analysis. ISPOR 20th Annual European Congress, Glasgow, UK, 4-8 Nov 2017.
Heggie, R., Wu, O. , White, P., Ford, G. A., Wardlaw, J., Brown, M. M., Clifton, A. and Muir, K. W. (2017) Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Cost-Effectiveness and Value of Implementation Analysis. 3rd European Stroke Organisation Conference (ESOC), Prague, Czech Republic, 16-18 May 2017.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- NanO2 in Large VessEL Occlusion Stroke: "NOVEL"
National Institute for Health Research
2023 - 2026
- NHS GG&C NRS Innovation Fellow
NHS Greater Glasgow and Clyde
2023 - 2023
- Scottish Imaging Network: A Platform for Scientific Excellence
University of Edinburgh
2023 - 2028
- Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE)
University of Edinburgh
2023 - 2028
- Alteplase-Tenecteplase Trial Evaluation for Stroke Thromobolysis
Stroke Association
2022 - 2023
- Development of in-vivo 19F Clinical MR imaging Using a Novel Hybrid 19F/1H Coil in Combination with an Intravenous Perfluorocarbon (ABL-101)
Wellcome Trust
2021 - 2023
- Development of 7T MRI Technology for Improved Neurovascular Imaging in Neurological Conditions
Neurosciences Foundation
2020 - 2021
- SINAPSE - Continued Development of SINAPSE
Scottish Funding Council
2020 - 2020
- The Insulin Resistance Intervention after Stroke Trial: A randomized, placebo-controlled trial of pioglitazone, compared with placebo, for prevention of stroke and myocardial infarction after ischemic stroke and transient ischemic attack (IRIS Trial)
National Institute of Neurological Disorders and Strokes
2019 - 2020
- What information does laminar fMRI provide about cortical sensorimotor circuits? Validation with electrophysiology and targeted nerve injuries
Biotechnology and Biological Sciences Research Council
2019 - 2022
- Multicentre, prospective randomised open label, blinded-endpoint (PROBE) controlled trial of thrombolysis with low dose Tenecteplase (TNK-tPA) versus standard of care in the prevention of disability at 3 months in minor ischaemic stroke with proven acute symptomatic occlusion (TEMPO-2).
British Heart Foundation (BHF)
2019 - 2022
- Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST-2) Imaging Substudy
British Heart Foundation
2019 - 2021
- I-CAIRD: Industrial Centre for AI Research in Digital Diagnostics
Innovate UK
2018 - 2021
- Whole-brain Human Ischaemic Stroke Perfusion and Extended Re-canalisation Study (WHISPER)
Chief Scientist Office
2018 - 2020
- Stroke/Imaging Block Award
The R S Macdonald Charitable Trust
2018 - 2019
- SINAPSE - Pools engagement in European Research & Postgrad and ECR Exchanges
Scottish Funding Council
2018 - 2019
- Brain Rhythms in Altered Vision after Stroke
Chief Scientist Office
2017 - 2017
- Whole brain Human Ischaemic Stroke Perfusion and Extended Re-canalisation (WHISPER) -Pilot Study
Neurosciences Foundation
2017 - 2019
- CiC Validating Molecular Targets in the Vascular Pathophysiology of CADASIL
Medical Research Council
2017 - 2018
- SINAPSE - Pools engagement in European Research (PEER) and Postgraduate and Early Career Researcher Exchanges (PECRE)
Scottish Funding Council
2016 - 2018
- The UK7T Network: developing the ultra-high field MRI platform for biomedical research.
Medical Research Council
2016 - 2019
- ATTEST 2: Alteplase-Tenecteplase Thrombolysis Efficacy in Stroke Thrombolysis
Stroke Association
2016 - 2021
- RESSTORE
European Commission
2015 - 2020
- Non invasive brain stimulation in stroke patients
Chief Scientist Office
2015 - 2018
- Pragmatic Ischaemic Thrombectomy Evaluation (PISTE) trial: A randomised controlled trial of mechanical thrombectomy in acute ischaemic stroke
National Institute for Health Research
2015 - 2019
- Continued Development of the SINAPSE Network
Scottish Funding Council
2015 - 2019
- Pools Engagement in European Research (PEER) (SINAPSE)
Scottish Funding Council
2015 - 2017
- Postgraduate and Early Career Researcher Exchanges (SINAPSE)
Scottish Funding Council
2015 - 2017
- Metabolite and protein profiling in CADASIL to unravel the vascular pathophysiology and natural history
NHS Greater Glasgow and Clyde Endowment Funds
2014 - 2016
- Pilot MRI Study for the Investigation of Pathophysiology in Intracerebral Haemorrhage
Academy of Medical Sciences
2014 - 2016
- Xanthine oxidase inhibition for improvement of Long-term Outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST)
Stroke Association
2014 - 2019
- Characterising vascular pathophysiology in CADASIL (cerebral autosomal dominant arteriopathy with subacute infarcts and leukoencephalopathy) by evaluation of gluteal resistance vessels
Stroke Association
2013 - 2016
- Penumbra and Recanalisation Acute CT in Ischaemic Stroke Evaluation (PRACTISE)
National Institute for Health Research
2013 - 2018
- Cerebral and peripheral perfusion and reactivity in CADASIL: a longitudinal pilot study
Chief Scientist Office
2013 - 2016
- Corticospinal reorganisation after experimental stroke.
Neurosciences Foundation
2012 - 2013
- Clinical Research Fellowships
NHS Greater Glasgow and Clyde
2012 - 2015
- Metabolic MRI in Acute Stroke; Development and Validation of the 'Oxygen Challenge' Technique
Chief Scientist Office
2012 - 2015
- PISTE (Pragmatic Ischaemic Stroke Thrombectomy Evaluation)
Stroke Association
2012 - 2015
- Supporting the ischaemic brain with oxygen-carrying perfluorocarbons.
Chief Scientist Office
2012 - 2015
- WAKE-UP
European Commission
2011 - 2017
- ATTEST: Pilot trial of Tenecteplase for Acute Ischaemic Stroke
Stroke Association
2011 - 2014
- Pilot Study of Susceptibility Weighted Imaging Based Oxygen Challenge in Hyperacute Stroke
Neurosciences Foundation
2011 - 2013
- An Assessment of the Cost Effectiveness of Magnetic Resonance Including Diffusion-Weighted Brain Imaging in Patients with Transient Ischaemic Attack and Minor Stroke
National Institute for Health Research
2010 - 2012
- Multimodal Imaging in Acute Ischemic Stroke
Chest Heart and Stroke Scotland
2010 - 2011
- SINAPSE-SPIRIT: Novel and collaborative approaches to knowledge exchange in translational imaging
Scottish Funding Council
2010 - 2013
- Metabolic syndrome, hyperglycemia and experimental stroke
Scottish Executive Health Department
2009 - 2010
- Scottish Hyperacute stroke Activity Register and Evaluation: SHARE
Chest Heart and Stroke Scotland
2009 - 2011
- Urinary catherterisation of newly diagnosed stroke patients
NHS Greater Glasgow and Clyde
2009 - 2010
- Central adjudication of modified Rankin scale disability assessments in acute stroke trials
Scottish Executive Health Department
2009 - 2011
- Pathophysiological relevance of acute post-stroke hyperglycaemia in relation to brain perfusion and arterial patency
Stroke Association
2008 - 2011
- Imaging the ischaemic penumbra using BOLD MRI with oxygen challenge as a biotracer
Medical Research Council
2008 - 2011
- Magnesium in acute lacunar stroke patients - preliminary exploration of scientific hypothesis and implementation of optimal design procedure
Scottish Executive Health Department
2005 - 2006
- Spectroscopic evaluation of lesion evolution in stroke - trial of insulin for acute lacticacidosis (SELESTIAL)
Stroke Association
2003 - 2006
- Managed Clinical Network for Stroke Neurology - Evaluation Project
Lanarkshire NHS Board
2003 - 2006
- Managed Clinical Network for Stroke Neurology - Evaluation Project
Scottish Executive Health Department
2003 - 2005
Supervision
Supervised Postgraduate Students
- Janhavi Ghosalkar (Postgraduate)
- Anis H Mohamed Guweidhi (Postgraduate)
- Steven Winata (Postgraduate)
Research Assistants
- Cameron Brown (Affiliate)
- Kristin Flegal (Senior Project Manager)
- Emma MacRae (Clinical Research Coordinator)
- Richard Mosses (SINAPSE Operations Manager)
