2022

Willis, A., Pratt, J. A. and Morris, B. J. (2022) Enzymatic degradation of cortical perineuronal nets reverses GABAergic interneuron maturation. Molecular Neurobiology, 59(5), pp. 2874-2893. (doi: 10.1007/s12035-022-02772-z) (PMID:35233718)

Openshaw, R. L. , Pratt, J. A. and Morris, B. J. (2022) The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. Disease Models and Mechanisms, 15(3), dmm049310. (doi: 10.1242/dmm.049310) (PMID:35275161) (PMCID:PMC8922023)

2021

Thomson, D. M., Mitchell, E. J., Openshaw, R. L. , Pratt, J. A. and Morris, B. J. (2021) Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction. Journal of Psychopharmacology, 35(10), pp. 1265-1276. (doi: 10.1177/02698811211032439) (PMID:34304635) (PMCID:PMC8521347)

Willis, A., Pratt, J. A. and Morris, B. J. (2021) BDNF and JNK signalling modulate cortical interneuron and perineuronal net development: implications for schizophrenia-linked 16p11.2 duplication syndrome. Schizophrenia Bulletin, 47(3), pp. 812-826. (doi: 10.1093/schbul/sbaa139) (PMID:33067994)

2020

Mitchell, E. J., Thomson, D. M., Openshaw, R. L. , Bristow, G. C., Dawson, N., Pratt, J. A. and Morris, B. (2020) Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions. Scientific Reports, 10, 12303. (doi: 10.1038/s41598-020-69130-8) (PMID:32704009) (PMCID:PMC7378168)

Bristow, G. C., Thomson, D. M., Openshaw, R. L. , Mitchell, E. J., Pratt, J. A., Dawson, N. and Morris, B. J. (2020) 16p11 duplication disrupts hippocampal-orbitofrontal-amygdala connectivity, revealing a neural circuit endophenotype for schizophrenia. Cell Reports, 31(3), 107536. (doi: 10.1016/j.celrep.2020.107536) (PMID:32320645)

Openshaw, R. , Thomson, D. M., Thompson, R., Penninger, J. M., Pratt, J. A., Morris, B. J. and Dawson, N. (2020) Map2k7 haploinsufficiency induces brain imaging endophenotypes and behavioral phenotypes relevant to schizophrenia. Schizophrenia Bulletin, 46(1), pp. 211-223. (doi: 10.1093/schbul/sbz044) (PMID:31219577) (PMCID:PMC6942167)

2019

Openshaw, R. L. , Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J. , Pratt, J. A. and Morris, B. J. (2019) JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. Journal of Neuroinflammation, 16(1), 18. (doi: 10.1186/s12974-019-1408-5) (PMID:30691477) (PMCID:PMC6350402)

2014

Winchester, C. L., Pratt, J. A. and Morris, B. J. (2014) Risk genes for schizophrenia: translational opportunities for drug discovery. Pharmacology and Therapeutics, 143(1), pp. 34-50. (doi: 10.1016/j.pharmthera.2014.02.003)

2013

Ewing, S. G., Porr, B. and Pratt, J. (2013) Deep brain stimulation of the mediodorsal thalamic nucleus yields increases in the expression of zif-268 but not c-fos in the frontal cortex. Journal of Chemical Neuroanatomy, 52, pp. 20-24. (doi: 10.1016/j.jchemneu.2013.04.002) (PMID:23660497)

Gilfillan, L., Blair, A., Morris, B. , Pratt, J., Schweiger, L., Pimlott, S. and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4(7), pp. 1118-1123. (doi: 10.1039/c3md00110e)

2012

Steward, L.J., Kennedy, M.D., Morris, B.J. and Pratt, J.A. (2012) Chronic phencyclidine (PCP)-induced modulation of muscarinic receptor mRNAs in rat brain: Impact of antipsychotic drug treatment. Neuropharmacology, 62(3), pp. 1554-1563. (doi: 10.1016/j.neuropharm.2011.05.016)

2011

Xiao, X., Dawson, N., MacIntyre, L., Morris, B.J. , Pratt, J.A., Watson, D.G. and Higham, D.J. (2011) Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition. BMC Systems Biology, 5(72), pp. 1-20. (doi: 10.1186/1752-0509-5-72)

2010

Dawson, N., Thompson, R.J., McVie, A., Thomson, D.M., Morris, B. J. and Pratt, J. A. (2010) Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity. Schizophrenia Bulletin, 38(3), pp. 457-474. (doi: 10.1093/schbul/sbq090)

Thomson, D.M., McVie, A., Morris, B.J. and Pratt, J.A. (2010) Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine. Psychopharmacology, 213(4), pp. 681-695. (doi: 10.1007/s00213-010-2020-7)

Articles

Willis, A., Pratt, J. A. and Morris, B. J. (2022) Enzymatic degradation of cortical perineuronal nets reverses GABAergic interneuron maturation. Molecular Neurobiology, 59(5), pp. 2874-2893. (doi: 10.1007/s12035-022-02772-z) (PMID:35233718)

Openshaw, R. L. , Pratt, J. A. and Morris, B. J. (2022) The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. Disease Models and Mechanisms, 15(3), dmm049310. (doi: 10.1242/dmm.049310) (PMID:35275161) (PMCID:PMC8922023)

Thomson, D. M., Mitchell, E. J., Openshaw, R. L. , Pratt, J. A. and Morris, B. J. (2021) Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction. Journal of Psychopharmacology, 35(10), pp. 1265-1276. (doi: 10.1177/02698811211032439) (PMID:34304635) (PMCID:PMC8521347)

Willis, A., Pratt, J. A. and Morris, B. J. (2021) BDNF and JNK signalling modulate cortical interneuron and perineuronal net development: implications for schizophrenia-linked 16p11.2 duplication syndrome. Schizophrenia Bulletin, 47(3), pp. 812-826. (doi: 10.1093/schbul/sbaa139) (PMID:33067994)

Mitchell, E. J., Thomson, D. M., Openshaw, R. L. , Bristow, G. C., Dawson, N., Pratt, J. A. and Morris, B. (2020) Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions. Scientific Reports, 10, 12303. (doi: 10.1038/s41598-020-69130-8) (PMID:32704009) (PMCID:PMC7378168)

Bristow, G. C., Thomson, D. M., Openshaw, R. L. , Mitchell, E. J., Pratt, J. A., Dawson, N. and Morris, B. J. (2020) 16p11 duplication disrupts hippocampal-orbitofrontal-amygdala connectivity, revealing a neural circuit endophenotype for schizophrenia. Cell Reports, 31(3), 107536. (doi: 10.1016/j.celrep.2020.107536) (PMID:32320645)

Openshaw, R. , Thomson, D. M., Thompson, R., Penninger, J. M., Pratt, J. A., Morris, B. J. and Dawson, N. (2020) Map2k7 haploinsufficiency induces brain imaging endophenotypes and behavioral phenotypes relevant to schizophrenia. Schizophrenia Bulletin, 46(1), pp. 211-223. (doi: 10.1093/schbul/sbz044) (PMID:31219577) (PMCID:PMC6942167)

Openshaw, R. L. , Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J. , Pratt, J. A. and Morris, B. J. (2019) JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. Journal of Neuroinflammation, 16(1), 18. (doi: 10.1186/s12974-019-1408-5) (PMID:30691477) (PMCID:PMC6350402)

Winchester, C. L., Pratt, J. A. and Morris, B. J. (2014) Risk genes for schizophrenia: translational opportunities for drug discovery. Pharmacology and Therapeutics, 143(1), pp. 34-50. (doi: 10.1016/j.pharmthera.2014.02.003)

Ewing, S. G., Porr, B. and Pratt, J. (2013) Deep brain stimulation of the mediodorsal thalamic nucleus yields increases in the expression of zif-268 but not c-fos in the frontal cortex. Journal of Chemical Neuroanatomy, 52, pp. 20-24. (doi: 10.1016/j.jchemneu.2013.04.002) (PMID:23660497)

Gilfillan, L., Blair, A., Morris, B. , Pratt, J., Schweiger, L., Pimlott, S. and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4(7), pp. 1118-1123. (doi: 10.1039/c3md00110e)

Steward, L.J., Kennedy, M.D., Morris, B.J. and Pratt, J.A. (2012) Chronic phencyclidine (PCP)-induced modulation of muscarinic receptor mRNAs in rat brain: Impact of antipsychotic drug treatment. Neuropharmacology, 62(3), pp. 1554-1563. (doi: 10.1016/j.neuropharm.2011.05.016)

Xiao, X., Dawson, N., MacIntyre, L., Morris, B.J. , Pratt, J.A., Watson, D.G. and Higham, D.J. (2011) Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition. BMC Systems Biology, 5(72), pp. 1-20. (doi: 10.1186/1752-0509-5-72)

Dawson, N., Thompson, R.J., McVie, A., Thomson, D.M., Morris, B. J. and Pratt, J. A. (2010) Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity. Schizophrenia Bulletin, 38(3), pp. 457-474. (doi: 10.1093/schbul/sbq090)

Thomson, D.M., McVie, A., Morris, B.J. and Pratt, J.A. (2010) Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine. Psychopharmacology, 213(4), pp. 681-695. (doi: 10.1007/s00213-010-2020-7)