Methods for recording & manipulating neuronal function


Our work is at the very frontier of current neuroscience research. We therefore rely on actively co-developing novel methodology to aid address our research questions in the best way possible. Through long-standing collaborations with the groups of Prof Martin Booth and Prof Harry Anderson in Oxford we have particular experience with the development of new optical methods for imaging and uncaging of compounds. We are also actively involved in developing new behavioural training and testing apparatus through our work with Dr Thomas Akam.

Papers from the lab on this topic

Akam T., Lustig A., Rowland J. M., Kapanaiah S. K. T., Esteve-Agraz J., Panniello M., Marquez C., Kohl M. M., Kätzel D., Costa R. M., Walton M. (2021) pyControl: Open source, Python based, hardware and software for controlling behavioural neuroscience experiments bioRxiv, 2021.02.22.432227. (doi: 10.1101/2021.02.22.432227)

Chong, E. Z., Panniello, M., Barreiros, I., Kohl, M. M., Booth, M. J. (2019) Quasi-simultaneous multiplane calcium imaging of neuronal circuits Biomedical Optics Express, 10, pp. 267-282. (doi: 10.1364/BOE.10.000267)

Khadria, A., Fleischhauer, J., Boczarow, I., Wilkinson, J. D., Kohl, M. M., Anderson, H. L. (2018) Porphyrin dyes for nonlinear optical imaging of live cells iScience, 4, pp. 153-163. (doi: 10.1016/j.isci.2018.05.015)

Kohl, M. M., Kätzel, D. (2017) Optogenetic mapping of neuronal connections and their plasticity Cambridge University Press,

Brown, T. G., Cogswell, C. J., Wilson, T., Chong, E. Z., Barreiros, I., Li, B., Kohl, M. M., Booth, M. J. (2017) Fast Multiplane Functional Imaging Combining Acousto-optic Switching and Remote Focusing (doi: 10.1117/12.2251476)

El-Gaby, M., Kohl, M. M., Paulsen, O. (2017) Optogenetic methods to study lateralized synaptic function Humana Press

Botcherby, E. J., Smith, C. W., Kohl, M. M., Débarre, D., Booth, M. J., Juškaitis, R., Paulsen, O., Wilson, T. (2012) Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates Proceedings of the National Academy of Sciences of the United States of America, 109, pp. 2919-2924. (doi: 10.1073/pnas.1111662109)

Reeve, J. E., Kohl, M. M., Rodríguez-Moreno, A., Paulsen, O., Anderson, H. L. (2012) Caged intracellular NMDA receptor blockers for the study of subcellular ion channel functionCommunicative and Integrative Biology, 5, pp. 240-242. (doi: 10.4161/cib.19400)

Rodríguez-Moreno, A., Kohl, M. M., Reeve, J. E., Eaton, T. R., Collins, H. A., Anderson, H. L., Paulsen, O. (2011) Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist Journal of Neuroscience, 31, pp. 8564-8569. (doi: 10.1523/JNEUROSCI.0274-11.2011)

Reeve, J. E., Collins, H. A., De Mey, K., Kohl, M. M., Thorley, K. J., Paulsen, O., Clays, K., Anderson, H. L. (2009) Amphiphilic porphyrins for second harmonic generation imaging Journal of the American Chemical Society, 131, pp. 2758-2759. (doi: 10.1021/ja8061369)