Inhibitory interneurons & neural codes

Overview

In collaboration with Prof Simon Butt we investigate how local, inhibitory circuits form during development. Together with Prof Blake Richards and Prof Jeehyun Kwag, we implement a multidisciplinary approach combining cellular, systems, behavioural and theoretical neuroscience, aimed at understanding the mechanisms by which rate and temporal codes could coexist in the brain and establishing an approach for artificially biasing neural activity towards rate or temporal codes. Our ongoing research focuses on the complementary roles of parvalbumin- and somatostatin-positive inhibitory interneurons.

Papers from the lab on this topic

Baruchin, L. J., Ghezzi, F., Kohl, M. M., Butt, S. J.B. (2021) Contribution of interneuron subtype-specific GABAergic signalling to emergent sensory processing in mouse somatosensory whisker barrel cortex Cerebral Cortex, in press.

Prince, L. Y., Tran, M. M., Grey, D., Saad, L., Chasiotis, H., Kwag, J., Kohl, M. M., Richards, B. A. (2021) Neocortical inhibitory interneuron subtypes are differentially attuned to synchrony- and rate-coded information Communications Biology, 4, (doi: 10.1038/s42003-021-02437-y)

Jang, H. J., Chung, H., Rowland, J. M., Richards, B. A., Kohl, M. M., Kwag, J. (2020) Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike-times in the neocortex Science Advances, 6, (doi: 10.1126/sciadv.aay5333)

Chung, H., Park, K., Jang, H. J., Kohl, M. M., Kwag, J. (2020) Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivoBrain Structure and Function, 225, pp. 935-954. (doi: 10.1007/s00429-020-02044-3)

Park, K., Lee, J., Jang, H. J., Richards, B. A., Kohl, M. M., Kwag, J. (2020) Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers BMC Biology, 18, (doi: 10.1186/s12915-019-0732-7)

Kohl, M. M., Paulsen, O. (2010) The roles of GABAB receptors in cortical network activity Advances in Pharmacology, 58, pp. 205-229. (doi: 10.1016/s1054-3589(10)58009-8)

Mann, E. O., Kohl, M. M., Paulsen, O. (2009) Distinct roles of GABAA and GABAB receptors in balancing and terminating persistent cortical activity Journal of Neuroscience, 29, pp. 7513-7518. (doi: 10.1523/JNEUROSCI.6162-08.2009)