Learning & Memory
Overview
Together with the groups of Prof David Bannerman in Oxford, Prof Jeehyun Kwag in Seoul, Prof Ole Paulsen in Cambridge and Dr Mick Craig in Glasgow, we study the circuitry and function of genetically identified neuronal populations during synaptic plasticity and associative memory tasks. We combine neuroanatomical tracing studies, optical and electrophysiological mapping of inputs and outputs, and opto- and chemogenetic circuit manipulations in behavioural studies. Ongoing work is focused on the retrosplenial cortex and examines changes in neuronal activity and learning in models of dementia-associated pathologies.
Papers from the lab on this topic
Park K., Kohl M. M., Kwag J. (2023) Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer’s disease model mice. Current Biology 34 (2), 434-443. e4
Chung H., Park K., Jang H. J., Kohl M. M., Kwag J. (2020) Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo. Brain Structure and Function 225, 935-954
Park, K., Lee, J., Jang, H. J., Richards, B. A., Kohl, M. M., Kwag, J. (2020) Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers BMC Biology, 18, (doi: 10.1186/s12915-019-0732-7)
Shipton, O. A., El-Gaby, M., Apergis-Schoute, J., Deisseroth, K., Bannerman, D. M., Paulsen, O., Kohl, M. M. (2014) Left–right dissociation of hippocampal memory processes in mice Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 15238-15243. (doi: 10.1073/pnas.1405648111)
Kohl, M. M., Shipton, O. A., Deacon, R. M., Rawlins, J. N. P., Deisseroth, K., Paulsen, O. (2011) Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity Nature Neuroscience, 14, pp. 1413-1415. (doi: 10.1038/nn.2915)
Rodríguez-Moreno, A., Kohl, M. M., Reeve, J. E., Eaton, T. R., Collins, H. A., Anderson, H. L., Paulsen, O. (2011) Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonistJournal of Neuroscience, 31, pp. 8564-8569. (doi: 10.1523/JNEUROSCI.0274-11.2011)