Dr Ewan McGhee

  • Affiliate (School of Physics & Astronomy)

email: e.mcghee@beatson.gla.ac.uk

Beatson Institute, Garscube Estate

Publications

List by: Type | Date

Jump to: 2021 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011
Number of items: 27.

2021

Ntala, C. et al. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001) (PMID:34337530) (PMCID:PMC8317840)

Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F. , Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J. and Machesky, L. M. (2021) The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice. Journal of Investigative Dermatology, 141(3), 628-637.e15. (doi: 10.1016/j.jid.2020.06.029) (PMID:32777214)

Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, 56. (doi: 10.1038/s41467-020-20255-4) (PMID:33397922) (PMCID:PMC7782582)

2019

Juin, A. et al. (2019) N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis. Developmental Cell, 51(4), 431-445.e7. (doi: 10.1016/j.devcel.2019.09.018) (PMID:31668663) (PMCID:PMC6863394)

Puttur, F. et al. (2019) Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans. Science Immunology, 4(36), eaav7638. (doi: 10.1126/sciimmunol.aav7638) (PMID:31175176) (PMCID:PMC6744282)

2018

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131) (PMID:29719257) (PMCID:PMC5946718)

Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J. and Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13(1), e0183585. (doi: 10.1371/journal.pone.0183585) (PMID:29293509) (PMCID:PMC5749721)

2017

Nobis, M. et al. (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21, pp. 274-288. (doi: 10.1016/j.celrep.2017.09.022) (PMID:28978480)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504. (doi: 10.1126/scitranslmed.aai8504) (PMID:28381539) (PMCID:PMC5777504)

Rath, N. et al. (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9(2), pp. 198-218. (doi: 10.15252/emmm.201606743) (PMID:28031255) (PMCID:PMC5286371)

2016

Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020) (PMID:26725115)

Kumar, A., Ouyang, M., Van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., Groisman, A., Goult, B. T., Anderson, K. I. and Schwartz, M. A. (2016) Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. Journal of Cell Biology, 213(3), pp. 371-383. (doi: 10.1083/jcb.201510012) (PMID:27161398) (PMCID:PMC4862330)

2015

Cameron, J. M., Gabrielsen, M. , Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H. and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi: 10.1016/j.cub.2015.04.020)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

2014

Johnsson, A.-K. E. et al. (2014) The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Reports, 6(6), pp. 1153-1164. (doi: 10.1016/j.celrep.2014.02.024)

Müllenbroich, M. C. , McGhee, E. J., Wright, A. J., Anderson, K. I. and Mathieson, K. (2014) Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinearin-vivoimaging. Journal of Biomedical Optics, 19(1), 016021. (doi: 10.1117/1.JBO.19.1.016021)

Nobis, M., McGhee, E. J., Herrmann, D., Magenau, A., Morton, J. P., Anderson, K. I. and Timpson, P. (2014) Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adhesion and Migration, 8(5), pp. 478-486. (doi: 10.4161/19336918.2014.970004)

2013

Nobis, M., Carragher, N.O., McGhee, E.J., Morton, J.P. , Sansom, O.J. , Anderson, K.I. and Timpson, P. (2013) Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS Journal, 280(21), pp. 5177-5197. (doi: 10.1111/febs.12348)

Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi: 10.1016/j.stem.2013.04.006)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)

2012

Radulescu, S. et al. (2012) Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Reports, 2(2), pp. 270-282. (doi: 10.1016/j.celrep.2012.07.003)

2011

McGhee, E. J., Morton, J. P. , Von Kriegsheim, A., Schwarz, J. P., Karim, S. A., Carragher, N. O., Sansom, O. , Anderson, K. I. and Timpson, P. (2011) FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion. Small GTPases, 2(4), pp. 239-244. (doi: 10.4161/sgtp.2.4.17275) (PMID:22145098) (PMCID:PMC3225915)

Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi: 10.1016/j.ccr.2011.05.008)

Timpson, P., McGhee, E.J. and Anderson, K.I. (2011) Imaging molecular dynamics in vivo - from cell biology to animal models. Journal of Cell Science, 124(17), pp. 2877-2890. (doi: 10.1242/jcs.085191)

This list was generated on Sun Sep 19 10:49:05 2021 BST.
Jump to: Articles
Number of items: 27.

Articles

Ntala, C. et al. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001) (PMID:34337530) (PMCID:PMC8317840)

Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F. , Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J. and Machesky, L. M. (2021) The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice. Journal of Investigative Dermatology, 141(3), 628-637.e15. (doi: 10.1016/j.jid.2020.06.029) (PMID:32777214)

Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, 56. (doi: 10.1038/s41467-020-20255-4) (PMID:33397922) (PMCID:PMC7782582)

Juin, A. et al. (2019) N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis. Developmental Cell, 51(4), 431-445.e7. (doi: 10.1016/j.devcel.2019.09.018) (PMID:31668663) (PMCID:PMC6863394)

Puttur, F. et al. (2019) Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans. Science Immunology, 4(36), eaav7638. (doi: 10.1126/sciimmunol.aav7638) (PMID:31175176) (PMCID:PMC6744282)

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131) (PMID:29719257) (PMCID:PMC5946718)

Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J. and Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13(1), e0183585. (doi: 10.1371/journal.pone.0183585) (PMID:29293509) (PMCID:PMC5749721)

Nobis, M. et al. (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21, pp. 274-288. (doi: 10.1016/j.celrep.2017.09.022) (PMID:28978480)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504. (doi: 10.1126/scitranslmed.aai8504) (PMID:28381539) (PMCID:PMC5777504)

Rath, N. et al. (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9(2), pp. 198-218. (doi: 10.15252/emmm.201606743) (PMID:28031255) (PMCID:PMC5286371)

Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020) (PMID:26725115)

Kumar, A., Ouyang, M., Van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., Groisman, A., Goult, B. T., Anderson, K. I. and Schwartz, M. A. (2016) Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. Journal of Cell Biology, 213(3), pp. 371-383. (doi: 10.1083/jcb.201510012) (PMID:27161398) (PMCID:PMC4862330)

Cameron, J. M., Gabrielsen, M. , Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H. and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi: 10.1016/j.cub.2015.04.020)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

Johnsson, A.-K. E. et al. (2014) The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Reports, 6(6), pp. 1153-1164. (doi: 10.1016/j.celrep.2014.02.024)

Müllenbroich, M. C. , McGhee, E. J., Wright, A. J., Anderson, K. I. and Mathieson, K. (2014) Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinearin-vivoimaging. Journal of Biomedical Optics, 19(1), 016021. (doi: 10.1117/1.JBO.19.1.016021)

Nobis, M., McGhee, E. J., Herrmann, D., Magenau, A., Morton, J. P., Anderson, K. I. and Timpson, P. (2014) Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adhesion and Migration, 8(5), pp. 478-486. (doi: 10.4161/19336918.2014.970004)

Nobis, M., Carragher, N.O., McGhee, E.J., Morton, J.P. , Sansom, O.J. , Anderson, K.I. and Timpson, P. (2013) Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS Journal, 280(21), pp. 5177-5197. (doi: 10.1111/febs.12348)

Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi: 10.1016/j.stem.2013.04.006)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)

Radulescu, S. et al. (2012) Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Reports, 2(2), pp. 270-282. (doi: 10.1016/j.celrep.2012.07.003)

McGhee, E. J., Morton, J. P. , Von Kriegsheim, A., Schwarz, J. P., Karim, S. A., Carragher, N. O., Sansom, O. , Anderson, K. I. and Timpson, P. (2011) FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion. Small GTPases, 2(4), pp. 239-244. (doi: 10.4161/sgtp.2.4.17275) (PMID:22145098) (PMCID:PMC3225915)

Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi: 10.1016/j.ccr.2011.05.008)

Timpson, P., McGhee, E.J. and Anderson, K.I. (2011) Imaging molecular dynamics in vivo - from cell biology to animal models. Journal of Cell Science, 124(17), pp. 2877-2890. (doi: 10.1242/jcs.085191)

This list was generated on Sun Sep 19 10:49:05 2021 BST.