Dr John Paul Leach

  • Professor of Clinical Neurology, Honorary Professor (School of Medicine, Dentistry & Nursing)

telephone: 01413308020
email: JohnPaul.Leach@glasgow.ac.uk

Dept of Neurology, Medicine - Clinical Neuroscience, Southern General Hospital, Glasgow, G51 4tf

ORCID iDhttps://orcid.org/0000-0003-2086-9937

Publications

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Jump to: 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1992
Number of items: 67.

2022

Craig, J. J., Scott, S. and Leach, J. P. (2022) Epilepsy and pregnancy: identifying risks. Practical Neurology, 22(2), pp. 98-106. (doi: 10.1136/practneurol-2019-002304) (PMID:34887343)

Marshall, A.D., Pell, J.P. , Askarieh, A., Leach, J.P. and Heath, C.A. (2022) The influence of demographics and comorbidity on persistence with anti-seizure medication. Seizure, 97, pp. 88-93. (doi: 10.1016/j.seizure.2022.03.019)

McTaggart, S., MacColl, G., Gronkowski, K., Wood, R., Leach, J. P. and Bennie, M. (2022) Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study. BMJ Open, 12(4), e058312. (doi: 10.1136/bmjopen-2021-058312) (PMID:35418434)

2021

Marson, A. G. et al. (2021) Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. Health Technology Assessment, 25(75), (doi: 10.3310/hta25750) (PMID:34931602)

Hope, D., Dewar, A., Hothersall, E. J., Leach, J. P. , Cameron, I. and Jaap, A. (2021) Measuring differential attainment: a longitudinal analysis of assessment results for 1512 medical students at four Scottish medical schools. BMJ Open, 11(9), e046056. (doi: 10.1136/bmjopen-2020-046056) (PMID:34479932) (PMCID:PMC8420706)

Huang, X., Malek, N., Simpson, J., Kalladka, D., Dunn, F. G. and Leach, J. P. (2021) Winning hearts and minds: ECG reporting in the first seizure clinic. BMC Cardiovascular Disorders, 21, 364. (doi: 10.1186/s12872-021-02174-4) (PMID:34332536) (PMCID:PMC8325235)

Marson, A. et al. (2021) The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet, 397(10282), pp. 1363-1374. (doi: 10.1016/S0140-6736(21)00247-6) (PMID:33838757) (PMCID:PMC8047799)

Marson, A. et al. (2021) The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet, 397(10282), pp. 1375-1386. (doi: 10.1016/S0140-6736(21)00246-4) (PMID:33838758) (PMCID:PMC8047813)

2020

Boyle, J.G., Colquhoun, I., Noonan, Z. , McDowall, S. , Walters, M.R. and Leach, J.P. (2020) Viva la VOSCE. BMC Medical Education, 20, 514. (doi: 10.1186/s12909-020-02444-3) (PMID:33334327) (PMCID:PMC7746425)

Mahmood, A., Abbasi, H. N., Ghouri, N. , Mohammed, R. and Leach, J. P. (2020) Managing epilepsy in Ramadan: guidance for healthcare providers and patients. Epilepsy and Behavior, 111, 107117. (doi: 10.1016/j.yebeh.2020.107117) (PMID:32599428)

Steinhoff, B. J., Christensen, J., Doherty, C. P., Majoie, M., De Backer, M., Hellot, S., Leunikava, I. and Leach, J. P. (2020) Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: second interim analysis of 6-month data from a prospective observational study in Europe. Epilepsy Research, 165, 106329. (doi: 10.1016/j.eplepsyres.2020.106329) (PMID:32623096)

Balbanova, S. et al. (2020) A study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II). BMJ Open, 10(8), (doi: 10.1136/bmjopen-2020- 040635) (PMID:32847927) (PMCID:PMC7451282)

Balabanova, S. et al. (2020) Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II). BMJ Open, 10(8), e040635. (doi: 10.1136/bmjopen-2020-040635) (PMID:32847927) (PMCID:PMC7451282)

Moss, L. , Henderson, M., Puxty, A., Shaw, M., Leach, J.P. , McPeake, J. and Quasim, T. (2020) Long‐term mortality of patients admitted to an intensive care unit with seizures: a population‐based study. Anaesthesia, 75(3), pp. 417-418. (doi: 10.1111/anae.14977) (PMID:32022911)

Kirby, J., Leach, V. M., Brockington, A., Patsalos, P., Reuber, M. and Leach, J. P. (2020) Drug withdrawal in the epilepsy monitoring unit – The patsalos table. Seizure, 75, pp. 75-81. (doi: 10.1016/j.seizure.2019.12.010) (PMID:31896534)

Noonan, Z. , Boyle, J. G., Pope, L. , Ditchfield, C. , Leach, J. P. and McDowall, S. (2020) Quarantining the OSCE: reflections on the Glasgow experience. Clinical Teacher, 17(1), pp. 94-97. (doi: 10.1111/tct.12993) (PMID:30592158)

Thomas, R. S., Craig, D. P. and Leach, J. P. (2020) The view of the clinician and the scientist on the family experience of sudden epilepsy deaths. Epilepsy and Behavior, 103(Part B), 106679. (doi: 10.1016/j.yebeh.2019.106679) (PMID:31822397)

2019

Leach, J. P. , Dani, K., MacDougall, N. J., Gallagher, P. and Newman, E. J. (2019) Neurological Scottish neologisms. Practical Neurology, 19(6), pp. 465-466. (doi: 10.1136/practneurol-2019-002426) (PMID:31611419)

Popkirov, S. et al. (2019) Hiding in plain sight: functional neurological disorders in the news. Journal of Neuropsychiatry and Clinical Neurosciences, 31(4), pp. 361-367. (doi: 10.1176/appi.neuropsych.19010025) (PMID:31117907) (PMCID:PMC7291360)

Maguire, D. et al. (2019) Low serum magnesium and 1-year mortality in alcohol withdrawal syndrome. European Journal of Clinical Investigation, 49(9), e13152. (doi: 10.1111/eci.13152) (PMID:31216056)

Abbasi, H. and Leach, J. P. (2019) Refractory status epilepticus in adults admitted to ITU in Glasgow 1995-2013 a longitudinal audit highlighting the need for action for provoked and unprovoked status epilepticus. Seizure, 65, pp. 138-143. (doi: 10.1016/j.seizure.2019.01.011) (PMID:30690407)

2018

Leach, J. P. (2018) Treatment of epilepsy – towards precision. F1000Research, 7, 1932. (doi: 10.12688/f1000research.16448.1) (PMID:30613377) (PMCID:PMC6305206)

Kearns, P. K.A. , Casey, H. A. and Leach, J. P. (2018) Hypothesis: Multiple sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons. Multiple Sclerosis and Related Disorders, 24, pp. 157-174. (doi: 10.1016/j.msard.2018.06.014) (PMID:30015080)

2017

Salim, O. J., Davidson, A., Li, K., Leach, J. P. and Heath, C. (2017) Brainstem encephalitis and acute polyneuropathy associated with hepatitis E infection. BMJ Case Reports, 2017, 220799. (doi: 10.1136/bcr-2017-220799) (PMID:28899886)

Leach, J.P. et al. (2017) Epilepsy and pregnancy: for healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group. Seizure, 50, pp. 67-72. (doi: 10.1016/j.seizure.2017.05.004) (PMID:28641176)

Nashef, L. and Leach, J. P. (2017) SUDEP, the aftermath: supporting the bereaved. Practical Neurology, 17(6), pp. 489-492. (doi: 10.1136/practneurol-2017-001729) (PMID:28972036)

2016

Donner, E. J., Waddell, B., Osland, K., Leach, J. P. , Duncan, S., Nashef, L. and Picot, M. C. (2016) After sudden unexpected death in epilepsy: lessons learned and the road forward. Epilepsia, 57(S1), pp. 46-53. (doi: 10.1111/epi.13235) (PMID:26749016)

2015

Leach, J. P. (2015) Death in pregnancy: a call for neurological action. Practical Neurology, 15(4), pp. 244-245. (doi: 10.1136/practneurol-2015-001097) (PMID:25828733)

2014

Gallagher, P., Leach, J. P. and Grant, R. (2014) Time to focus on brain tumor-related epilepsy trials. Neuro-Oncology Practice, 1(3), pp. 123-133. (doi: 10.1093/nop/npu010) (PMID:31386030) (PMCID:PMC6657385)

Leach, J.P. (2014) Diagnosis of loss of consciousness: when art meets science. Seizure, 23(7), p. 495. (doi: 10.1016/j.seizure.2014.05.001) (PMID:24890931)

Leach, J. , Bagot, C. and Tait, R.C. (2014) Diagnosis and initial management of venous thrombosis; an audit of compliance with local and national guidelines. British Journal of Haematology, 165(s1), p. 43. (doi: 10.1111/bjh.12802) (PMID:24766253)

Al-Shahi Salman, R. et al. (2014) Outcome after conservative management or intervention for unruptured brain arteriovenous malformations. JAMA: Journal of the American Medical Association, 311(16), pp. 1661-1669. (doi: 10.1001/jama.2014.3200) (PMID:24756516)

Leach, J.P. (2014) Antiepileptic drug therapy. In: Aminoff, M. J. and Daroff, R. B. (eds.) Encyclopedia of the Neurological Sciences (Second Edition). Academic Press: Amsterdam, pp. 224-232. ISBN 9780123851581 (doi: 10.1016/B978-0-12-385157-4.00277-3)

2013

Leach, J.P. and Abassi, H. (2013) Modern management of epilepsy. Clinical Medicine, 13(1), pp. 84-86. (doi: 10.7861/clinmedicine.13-1-84) (PMID:23472502) (PMCID:PMC5873717)

2012

Leach, J. P. , Mohanraj, R. and Borland, W. (2012) Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. Epilepsia, 53(s4), pp. 48-57. (doi: 10.1111/j.1528-1167.2012.03613.x) (PMID:22946721)

Leach, J. P. (2012) SUDEP discussions with patients and families. Practical Neurology, 12(2), pp. 103-106. (doi: 10.1136/practneurol-2011-000184) (PMID:22450457)

2011

Josephson, C.B., Leach, J.-P. , Duncan, R., Roberts, R.C., Counsell, C.E. and Al-Shahi Salman, R. (2011) Seizure risk from cavernous or arteriovenous malformations: prospective population-based study. Neurology, 76(18), pp. 1548-1554. (doi: 10.1212/WNL.0b013e3182190f37) (PMID:21536634) (PMCID:PMC3100127)

Newman, E. J., Cooper, S., Jampana, R. and Leach, J. P. (2011) Thinking outside of the box. Practical Neurology, 11(1), pp. 44-47. (doi: 10.1136/jnnp.2010.235853) (PMID:21239655)

2010

Angus-Leppan, H. and Leach, J. P. (2010) A new era in acute neurological consultations. European Journal of Neurology, 17(4), e26-e27. (doi: 10.1111/j.1468-1331.2008.02904.x) (PMID:20050901)

Sander, L., Jacoby, A. and Leach, J. P. (2010) Can a patient-centred approach to epilepsy improve outcomes? Progress in Neurology and Psychiatry, 14(2), pp. 27-32. (doi: 10.1002/pnp.159)

Al Zweiri, M., Sills, G. J., Leach, J. P., Brodie, M. J., Robertson, C., Watson, D. G. and Parkinson, J. A. (2010) Response to drug treatment in newly diagnosed epilepsy: A pilot study of H-1 NMR- and MS-based metabonomic analysis. Epilepsy Research, 88(2-3), pp. 189-195. (doi: 10.1016/j.eplepsyres.2009.11.005)

2009

Leach, J. P. (2009) When the antiepileptic drugs are not working. Practical Neurology, 9, pp. 27-32. (doi: 10.1136/jnnp.2008.166124) (PMID:19151235)

2008

Leach, J. P. (2008) Overuse of the EEG. Practical Neurology, 8(1), p. 68. (doi: 10.1136/jnnp.2007.139733) (PMID:18230713)

2007

Stephen, L. J., Sills, G. J., Leach, J. P., Butler, E., Parker, P., Hitiris, N., Leach, V. M., Wilson, E. A. and Brodie, M. J. (2007) Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. Epilepsy Research, 75(2-3), pp. 122-129. (doi: 10.1016/j.eplepsyres.2007.04.009) (PMID:17553671)

Peters, G., Leach, J.P. and Larner, A.J. (2007) Pseudostatus epilepticus in pregnancy. International Journal of Gynecology and Obstetrics, 97(1), p. 47. (doi: 10.1016/j.ijgo.2006.12.008) (PMID:17313950)

Marson, A. G. et al. (2007) The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet, 369(9566), pp. 1000-1015. (doi: 10.1016/S0140-6736(07)60460-7) (PMID:17382827) (PMCID:PMC2080688)

Marson, A. G. et al. (2007) The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet, 369(9566), pp. 1016-1026. (doi: 10.1016/S0140-6736(07)60461-9) (PMID:17382828) (PMCID:PMC2039891)

Leschziner, G. D., Andrew, T., Leach, J. P. , Chadwick, D., Coffey, A. J., Balding, D. J., Bentley, D. R., Pirmohamed, M. and Johnson, M. R. (2007) Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. Pharmacogenetics and Genomics, 17(3), pp. 217-230. (doi: 10.1097/01.fpc.0000230408.23146.b1) (PMID:17460550)

2006

Razvi, S. S. M. and Leach, J. P. (2006) Asymptomatic pontine myelinolysis. European Journal of Neurology, 13(11), pp. 1261-1263. (doi: 10.1111/j.1468-1331.2006.01456.x) (PMID:17038043)

2005

Leach, J.P. (2005) Consensus in prescribing. International Congress and Symposium Series - Royal Society of Medicine(260),

2004

Leach, J. P. (2004) Levetiracetam in the management of epilepsy. Hospital Medicine, 65(12), pp. 740-744. (doi: 10.12968/hosp.2004.65.12.740) (PMID:15624450)

2001

Leach, J. P. , Marson, T. and Chadwick, D. (2001) New antiepileptic drugs revolution or marketing spin? Practical Neurology, 1(2), pp. 70-81. (doi: 10.1046/j.1474-7766.2001.00002.x)

Nicolson, A. and Leach, J. P. (2001) Future prospects for the drug treatment of epilepsy. CNS Drugs, 15(12), pp. 955-968. (doi: 10.2165/00023210-200115120-00005) (PMID:11735615)

Marson, A.G., Hutton, J.L., Leach, J.P. , Castillo, S., Schmidt, D., White, S., Chaisewikul, R., Privitera, M. and Chadwick, D.W. (2001) Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review. Epilepsy Research, 46(3), pp. 259-270. (doi: 10.1016/S0920-1211(01)00287-X) (PMID:11518627)

2000

Sills, G. J., Leach, J. P. P. , Kilpatrick, W. S., Fraser, C. M., Thompson, G. G. and Brodie, M. J. (2000) Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt. Epilepsia, 41(s1), pp. 30-34. (doi: 10.1111/j.1528-1157.2000.tb02168.x) (PMID:10768297)

1999

Leach, J.P. , Chadwick, D.W., Miles, J.B. and Hart, I.K. (1999) Improvement in adult-onset Rasmussen's encephalitis with long-term immunomodulatory therapy. Neurology, 52(4), pp. 738-742. (doi: 10.1212/WNL.52.4.738) (PMID:10078719)

1998

O'Driscoll, K. and Leach, J. P. (1998) "No longer Gage": an iron bar through the head. Early observations of personality change after injury to the prefrontal cortex. British Medical Journal, 317(7174), pp. 1673-1674. (doi: 10.1136/bmj.317.7174.1673a) (PMID:9857119) (PMCID:PMC1114479)

Rao, G. P., Fat, F. A., Kyle, G., Leach, J. P. , Chadwick, D. W. and Batterbury, M. (1998) Study is needed of visual field defects associated with any long term antiepileptic drug. British Medical Journal, 317(7152), p. 206. (doi: 10.1136/bmj.317.7152.206) (PMID:9665915) (PMCID:PMC1113550)

Leach, J. P. (1998) The poster session: is the writing on the wall? British Medical Journal, 316(7125), p. 157. (doi: 10.1136/bmj.316.7125.157)

1997

Leach, J. P. (1997) Polypharmacy with anticonvulsants: focus on synergism. CNS Drugs, 8(5), pp. 366-375. (doi: 10.2165/00023210-199708050-00003)

Leach, J. P. , Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of gabapentin in mouse brain. Epilepsy Research, 27(3), pp. 175-180. (doi: 10.1016/S0920-1211(97)01034-6) (PMID:9237051)

Sills, G. J., Leach, J. P. , Fraser, C. M., Forrest, G., Patsalos, P. N. and Brodie, M. J. (1997) Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. European Journal of Pharmacology, 325(1), pp. 35-40. (doi: 10.1016/S0014-2999(97)00105-2) (PMID:9151936)

Leach, J. P. , Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain. British Journal of Pharmacology, 121(5), pp. 923-926. (doi: 10.1038/sj.bjp.0701219) (PMID:9222548) (PMCID:PMC1564774)

1996

Leach, J. P. , Sills, G. J., Majid, A., Butler, E., Carswell, A., Thompson, G. G. and Brodie, M. J. (1996) Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure, 5(3), pp. 229-234. (doi: 10.1016/S1059-1311(96)80041-0) (PMID:8902926)

Forrest, G., Sills, G. J., Leach, J. P. and Brodie, M. J. (1996) Determination of gabapentin in plasma by high-performance liquid chromatography. Journal of Chromatography B, 681(2), pp. 421-425. (doi: 10.1016/0378-4347(96)00074-6) (PMID:8811458)

1992

Collier, A., Rumley, A., Rumley, A. G., Patesron, J. R., Leach, J. P. , Lowe, G. D.O. and Small, M. (1992) Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria. Diabetes, 41(8), pp. 909-913. (doi: 10.2337/diab.41.8.909) (PMID:1628764)

Collier, A., Leach, J. P. , McLelland, A., Jardine, A. , Morton, J. J. and Small, M. (1992) Plasma endothelinlike immunoreactivity levels in IDDM patients with microalbuminuria. Diabetes Care, 15(8), pp. 1038-1040. (doi: 10.2337/diacare.15.8.1038) (PMID:1505306)

This list was generated on Wed Jul 6 08:59:55 2022 BST.
Number of items: 67.

Articles

Craig, J. J., Scott, S. and Leach, J. P. (2022) Epilepsy and pregnancy: identifying risks. Practical Neurology, 22(2), pp. 98-106. (doi: 10.1136/practneurol-2019-002304) (PMID:34887343)

Marshall, A.D., Pell, J.P. , Askarieh, A., Leach, J.P. and Heath, C.A. (2022) The influence of demographics and comorbidity on persistence with anti-seizure medication. Seizure, 97, pp. 88-93. (doi: 10.1016/j.seizure.2022.03.019)

McTaggart, S., MacColl, G., Gronkowski, K., Wood, R., Leach, J. P. and Bennie, M. (2022) Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study. BMJ Open, 12(4), e058312. (doi: 10.1136/bmjopen-2021-058312) (PMID:35418434)

Marson, A. G. et al. (2021) Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. Health Technology Assessment, 25(75), (doi: 10.3310/hta25750) (PMID:34931602)

Hope, D., Dewar, A., Hothersall, E. J., Leach, J. P. , Cameron, I. and Jaap, A. (2021) Measuring differential attainment: a longitudinal analysis of assessment results for 1512 medical students at four Scottish medical schools. BMJ Open, 11(9), e046056. (doi: 10.1136/bmjopen-2020-046056) (PMID:34479932) (PMCID:PMC8420706)

Huang, X., Malek, N., Simpson, J., Kalladka, D., Dunn, F. G. and Leach, J. P. (2021) Winning hearts and minds: ECG reporting in the first seizure clinic. BMC Cardiovascular Disorders, 21, 364. (doi: 10.1186/s12872-021-02174-4) (PMID:34332536) (PMCID:PMC8325235)

Marson, A. et al. (2021) The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet, 397(10282), pp. 1363-1374. (doi: 10.1016/S0140-6736(21)00247-6) (PMID:33838757) (PMCID:PMC8047799)

Marson, A. et al. (2021) The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet, 397(10282), pp. 1375-1386. (doi: 10.1016/S0140-6736(21)00246-4) (PMID:33838758) (PMCID:PMC8047813)

Boyle, J.G., Colquhoun, I., Noonan, Z. , McDowall, S. , Walters, M.R. and Leach, J.P. (2020) Viva la VOSCE. BMC Medical Education, 20, 514. (doi: 10.1186/s12909-020-02444-3) (PMID:33334327) (PMCID:PMC7746425)

Mahmood, A., Abbasi, H. N., Ghouri, N. , Mohammed, R. and Leach, J. P. (2020) Managing epilepsy in Ramadan: guidance for healthcare providers and patients. Epilepsy and Behavior, 111, 107117. (doi: 10.1016/j.yebeh.2020.107117) (PMID:32599428)

Steinhoff, B. J., Christensen, J., Doherty, C. P., Majoie, M., De Backer, M., Hellot, S., Leunikava, I. and Leach, J. P. (2020) Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: second interim analysis of 6-month data from a prospective observational study in Europe. Epilepsy Research, 165, 106329. (doi: 10.1016/j.eplepsyres.2020.106329) (PMID:32623096)

Balbanova, S. et al. (2020) A study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II). BMJ Open, 10(8), (doi: 10.1136/bmjopen-2020- 040635) (PMID:32847927) (PMCID:PMC7451282)

Balabanova, S. et al. (2020) Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II). BMJ Open, 10(8), e040635. (doi: 10.1136/bmjopen-2020-040635) (PMID:32847927) (PMCID:PMC7451282)

Moss, L. , Henderson, M., Puxty, A., Shaw, M., Leach, J.P. , McPeake, J. and Quasim, T. (2020) Long‐term mortality of patients admitted to an intensive care unit with seizures: a population‐based study. Anaesthesia, 75(3), pp. 417-418. (doi: 10.1111/anae.14977) (PMID:32022911)

Kirby, J., Leach, V. M., Brockington, A., Patsalos, P., Reuber, M. and Leach, J. P. (2020) Drug withdrawal in the epilepsy monitoring unit – The patsalos table. Seizure, 75, pp. 75-81. (doi: 10.1016/j.seizure.2019.12.010) (PMID:31896534)

Noonan, Z. , Boyle, J. G., Pope, L. , Ditchfield, C. , Leach, J. P. and McDowall, S. (2020) Quarantining the OSCE: reflections on the Glasgow experience. Clinical Teacher, 17(1), pp. 94-97. (doi: 10.1111/tct.12993) (PMID:30592158)

Thomas, R. S., Craig, D. P. and Leach, J. P. (2020) The view of the clinician and the scientist on the family experience of sudden epilepsy deaths. Epilepsy and Behavior, 103(Part B), 106679. (doi: 10.1016/j.yebeh.2019.106679) (PMID:31822397)

Leach, J. P. , Dani, K., MacDougall, N. J., Gallagher, P. and Newman, E. J. (2019) Neurological Scottish neologisms. Practical Neurology, 19(6), pp. 465-466. (doi: 10.1136/practneurol-2019-002426) (PMID:31611419)

Popkirov, S. et al. (2019) Hiding in plain sight: functional neurological disorders in the news. Journal of Neuropsychiatry and Clinical Neurosciences, 31(4), pp. 361-367. (doi: 10.1176/appi.neuropsych.19010025) (PMID:31117907) (PMCID:PMC7291360)

Maguire, D. et al. (2019) Low serum magnesium and 1-year mortality in alcohol withdrawal syndrome. European Journal of Clinical Investigation, 49(9), e13152. (doi: 10.1111/eci.13152) (PMID:31216056)

Abbasi, H. and Leach, J. P. (2019) Refractory status epilepticus in adults admitted to ITU in Glasgow 1995-2013 a longitudinal audit highlighting the need for action for provoked and unprovoked status epilepticus. Seizure, 65, pp. 138-143. (doi: 10.1016/j.seizure.2019.01.011) (PMID:30690407)

Leach, J. P. (2018) Treatment of epilepsy – towards precision. F1000Research, 7, 1932. (doi: 10.12688/f1000research.16448.1) (PMID:30613377) (PMCID:PMC6305206)

Kearns, P. K.A. , Casey, H. A. and Leach, J. P. (2018) Hypothesis: Multiple sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons. Multiple Sclerosis and Related Disorders, 24, pp. 157-174. (doi: 10.1016/j.msard.2018.06.014) (PMID:30015080)

Salim, O. J., Davidson, A., Li, K., Leach, J. P. and Heath, C. (2017) Brainstem encephalitis and acute polyneuropathy associated with hepatitis E infection. BMJ Case Reports, 2017, 220799. (doi: 10.1136/bcr-2017-220799) (PMID:28899886)

Leach, J.P. et al. (2017) Epilepsy and pregnancy: for healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group. Seizure, 50, pp. 67-72. (doi: 10.1016/j.seizure.2017.05.004) (PMID:28641176)

Nashef, L. and Leach, J. P. (2017) SUDEP, the aftermath: supporting the bereaved. Practical Neurology, 17(6), pp. 489-492. (doi: 10.1136/practneurol-2017-001729) (PMID:28972036)

Donner, E. J., Waddell, B., Osland, K., Leach, J. P. , Duncan, S., Nashef, L. and Picot, M. C. (2016) After sudden unexpected death in epilepsy: lessons learned and the road forward. Epilepsia, 57(S1), pp. 46-53. (doi: 10.1111/epi.13235) (PMID:26749016)

Leach, J. P. (2015) Death in pregnancy: a call for neurological action. Practical Neurology, 15(4), pp. 244-245. (doi: 10.1136/practneurol-2015-001097) (PMID:25828733)

Gallagher, P., Leach, J. P. and Grant, R. (2014) Time to focus on brain tumor-related epilepsy trials. Neuro-Oncology Practice, 1(3), pp. 123-133. (doi: 10.1093/nop/npu010) (PMID:31386030) (PMCID:PMC6657385)

Leach, J.P. (2014) Diagnosis of loss of consciousness: when art meets science. Seizure, 23(7), p. 495. (doi: 10.1016/j.seizure.2014.05.001) (PMID:24890931)

Leach, J. , Bagot, C. and Tait, R.C. (2014) Diagnosis and initial management of venous thrombosis; an audit of compliance with local and national guidelines. British Journal of Haematology, 165(s1), p. 43. (doi: 10.1111/bjh.12802) (PMID:24766253)

Al-Shahi Salman, R. et al. (2014) Outcome after conservative management or intervention for unruptured brain arteriovenous malformations. JAMA: Journal of the American Medical Association, 311(16), pp. 1661-1669. (doi: 10.1001/jama.2014.3200) (PMID:24756516)

Leach, J.P. and Abassi, H. (2013) Modern management of epilepsy. Clinical Medicine, 13(1), pp. 84-86. (doi: 10.7861/clinmedicine.13-1-84) (PMID:23472502) (PMCID:PMC5873717)

Leach, J. P. , Mohanraj, R. and Borland, W. (2012) Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. Epilepsia, 53(s4), pp. 48-57. (doi: 10.1111/j.1528-1167.2012.03613.x) (PMID:22946721)

Leach, J. P. (2012) SUDEP discussions with patients and families. Practical Neurology, 12(2), pp. 103-106. (doi: 10.1136/practneurol-2011-000184) (PMID:22450457)

Josephson, C.B., Leach, J.-P. , Duncan, R., Roberts, R.C., Counsell, C.E. and Al-Shahi Salman, R. (2011) Seizure risk from cavernous or arteriovenous malformations: prospective population-based study. Neurology, 76(18), pp. 1548-1554. (doi: 10.1212/WNL.0b013e3182190f37) (PMID:21536634) (PMCID:PMC3100127)

Newman, E. J., Cooper, S., Jampana, R. and Leach, J. P. (2011) Thinking outside of the box. Practical Neurology, 11(1), pp. 44-47. (doi: 10.1136/jnnp.2010.235853) (PMID:21239655)

Angus-Leppan, H. and Leach, J. P. (2010) A new era in acute neurological consultations. European Journal of Neurology, 17(4), e26-e27. (doi: 10.1111/j.1468-1331.2008.02904.x) (PMID:20050901)

Sander, L., Jacoby, A. and Leach, J. P. (2010) Can a patient-centred approach to epilepsy improve outcomes? Progress in Neurology and Psychiatry, 14(2), pp. 27-32. (doi: 10.1002/pnp.159)

Al Zweiri, M., Sills, G. J., Leach, J. P., Brodie, M. J., Robertson, C., Watson, D. G. and Parkinson, J. A. (2010) Response to drug treatment in newly diagnosed epilepsy: A pilot study of H-1 NMR- and MS-based metabonomic analysis. Epilepsy Research, 88(2-3), pp. 189-195. (doi: 10.1016/j.eplepsyres.2009.11.005)

Leach, J. P. (2009) When the antiepileptic drugs are not working. Practical Neurology, 9, pp. 27-32. (doi: 10.1136/jnnp.2008.166124) (PMID:19151235)

Leach, J. P. (2008) Overuse of the EEG. Practical Neurology, 8(1), p. 68. (doi: 10.1136/jnnp.2007.139733) (PMID:18230713)

Stephen, L. J., Sills, G. J., Leach, J. P., Butler, E., Parker, P., Hitiris, N., Leach, V. M., Wilson, E. A. and Brodie, M. J. (2007) Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. Epilepsy Research, 75(2-3), pp. 122-129. (doi: 10.1016/j.eplepsyres.2007.04.009) (PMID:17553671)

Peters, G., Leach, J.P. and Larner, A.J. (2007) Pseudostatus epilepticus in pregnancy. International Journal of Gynecology and Obstetrics, 97(1), p. 47. (doi: 10.1016/j.ijgo.2006.12.008) (PMID:17313950)

Marson, A. G. et al. (2007) The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet, 369(9566), pp. 1000-1015. (doi: 10.1016/S0140-6736(07)60460-7) (PMID:17382827) (PMCID:PMC2080688)

Marson, A. G. et al. (2007) The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet, 369(9566), pp. 1016-1026. (doi: 10.1016/S0140-6736(07)60461-9) (PMID:17382828) (PMCID:PMC2039891)

Leschziner, G. D., Andrew, T., Leach, J. P. , Chadwick, D., Coffey, A. J., Balding, D. J., Bentley, D. R., Pirmohamed, M. and Johnson, M. R. (2007) Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. Pharmacogenetics and Genomics, 17(3), pp. 217-230. (doi: 10.1097/01.fpc.0000230408.23146.b1) (PMID:17460550)

Razvi, S. S. M. and Leach, J. P. (2006) Asymptomatic pontine myelinolysis. European Journal of Neurology, 13(11), pp. 1261-1263. (doi: 10.1111/j.1468-1331.2006.01456.x) (PMID:17038043)

Leach, J.P. (2005) Consensus in prescribing. International Congress and Symposium Series - Royal Society of Medicine(260),

Leach, J. P. (2004) Levetiracetam in the management of epilepsy. Hospital Medicine, 65(12), pp. 740-744. (doi: 10.12968/hosp.2004.65.12.740) (PMID:15624450)

Leach, J. P. , Marson, T. and Chadwick, D. (2001) New antiepileptic drugs revolution or marketing spin? Practical Neurology, 1(2), pp. 70-81. (doi: 10.1046/j.1474-7766.2001.00002.x)

Nicolson, A. and Leach, J. P. (2001) Future prospects for the drug treatment of epilepsy. CNS Drugs, 15(12), pp. 955-968. (doi: 10.2165/00023210-200115120-00005) (PMID:11735615)

Marson, A.G., Hutton, J.L., Leach, J.P. , Castillo, S., Schmidt, D., White, S., Chaisewikul, R., Privitera, M. and Chadwick, D.W. (2001) Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review. Epilepsy Research, 46(3), pp. 259-270. (doi: 10.1016/S0920-1211(01)00287-X) (PMID:11518627)

Sills, G. J., Leach, J. P. P. , Kilpatrick, W. S., Fraser, C. M., Thompson, G. G. and Brodie, M. J. (2000) Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt. Epilepsia, 41(s1), pp. 30-34. (doi: 10.1111/j.1528-1157.2000.tb02168.x) (PMID:10768297)

Leach, J.P. , Chadwick, D.W., Miles, J.B. and Hart, I.K. (1999) Improvement in adult-onset Rasmussen's encephalitis with long-term immunomodulatory therapy. Neurology, 52(4), pp. 738-742. (doi: 10.1212/WNL.52.4.738) (PMID:10078719)

O'Driscoll, K. and Leach, J. P. (1998) "No longer Gage": an iron bar through the head. Early observations of personality change after injury to the prefrontal cortex. British Medical Journal, 317(7174), pp. 1673-1674. (doi: 10.1136/bmj.317.7174.1673a) (PMID:9857119) (PMCID:PMC1114479)

Rao, G. P., Fat, F. A., Kyle, G., Leach, J. P. , Chadwick, D. W. and Batterbury, M. (1998) Study is needed of visual field defects associated with any long term antiepileptic drug. British Medical Journal, 317(7152), p. 206. (doi: 10.1136/bmj.317.7152.206) (PMID:9665915) (PMCID:PMC1113550)

Leach, J. P. (1998) The poster session: is the writing on the wall? British Medical Journal, 316(7125), p. 157. (doi: 10.1136/bmj.316.7125.157)

Leach, J. P. (1997) Polypharmacy with anticonvulsants: focus on synergism. CNS Drugs, 8(5), pp. 366-375. (doi: 10.2165/00023210-199708050-00003)

Leach, J. P. , Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of gabapentin in mouse brain. Epilepsy Research, 27(3), pp. 175-180. (doi: 10.1016/S0920-1211(97)01034-6) (PMID:9237051)

Sills, G. J., Leach, J. P. , Fraser, C. M., Forrest, G., Patsalos, P. N. and Brodie, M. J. (1997) Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. European Journal of Pharmacology, 325(1), pp. 35-40. (doi: 10.1016/S0014-2999(97)00105-2) (PMID:9151936)

Leach, J. P. , Sills, G. J., Butler, E., Forrest, G., Thompson, G. G. and Brodie, M. J. (1997) Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain. British Journal of Pharmacology, 121(5), pp. 923-926. (doi: 10.1038/sj.bjp.0701219) (PMID:9222548) (PMCID:PMC1564774)

Leach, J. P. , Sills, G. J., Majid, A., Butler, E., Carswell, A., Thompson, G. G. and Brodie, M. J. (1996) Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure, 5(3), pp. 229-234. (doi: 10.1016/S1059-1311(96)80041-0) (PMID:8902926)

Forrest, G., Sills, G. J., Leach, J. P. and Brodie, M. J. (1996) Determination of gabapentin in plasma by high-performance liquid chromatography. Journal of Chromatography B, 681(2), pp. 421-425. (doi: 10.1016/0378-4347(96)00074-6) (PMID:8811458)

Collier, A., Rumley, A., Rumley, A. G., Patesron, J. R., Leach, J. P. , Lowe, G. D.O. and Small, M. (1992) Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria. Diabetes, 41(8), pp. 909-913. (doi: 10.2337/diab.41.8.909) (PMID:1628764)

Collier, A., Leach, J. P. , McLelland, A., Jardine, A. , Morton, J. J. and Small, M. (1992) Plasma endothelinlike immunoreactivity levels in IDDM patients with microalbuminuria. Diabetes Care, 15(8), pp. 1038-1040. (doi: 10.2337/diacare.15.8.1038) (PMID:1505306)

Book Sections

Leach, J.P. (2014) Antiepileptic drug therapy. In: Aminoff, M. J. and Daroff, R. B. (eds.) Encyclopedia of the Neurological Sciences (Second Edition). Academic Press: Amsterdam, pp. 224-232. ISBN 9780123851581 (doi: 10.1016/B978-0-12-385157-4.00277-3)

This list was generated on Wed Jul 6 08:59:55 2022 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Evaluating Fairness In Assessment At Four Scottish Medical Schools Pat MacLennan, SMERC Administrator, Email: pmaclennan@abdn.ac.uk

    2019 - 2019