Dr Denise Hough

  • Lecturer in Biology (Life Sciences General Teaching)
  • Associate (Institute of Biodiversity Animal Health & Comparative Medicine)

telephone: 01413308480
email: Denise.Hough@glasgow.ac.uk

Biography

University of Stellenbosch, South Africa:

BSc Animal Biotechnology

Hons Biochemistry

PhD Biochemistry

Post-doctoral training:

2012-2013, Western Cape Department of Agriculture in collaboration with the University of Stellenbosch

2013-2019, University of Glasgow in the Institute of Biodiversity, Animal Health and Comparative Medicine

2018-2019, University of Glasgow in the Institute of Cardiovascular and Medical Sciences

 


Research interests

I am interested in how steroid hormone production changes dynamically over an individual's lifespan and the physiological processes that it influences. Some of my research are molecular and cellular based, such as investigations of tissue-specific steroid biosynthesis. Other areas of research utilise physiological and behavioural approaches to investigate the role of steroids during critical periods of development to program health later in life. 


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2015 | 2013 | 2012 | 2010 | 2009
Number of items: 13.

2019

Hough, D., Robinson, J.E. , Bellingham, M. , Fleming, L.M., McLaughlin, M. , Jama, K., Haraldsen, I.R.H., Solbakk, A.K. and Evans, N.P. (2019) Peripubertal GnRH and testosterone co-treatment leads to increased familiarity preferences in male sheep. Psychoneuroendocrinology, 108, pp. 70-77. (doi:10.1016/j.psyneuen.2019.06.008) (PMID:31229635)

O'Shaughnessy, P. J. et al. (2019) Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biology, 17(2), e3000002. (doi:10.1371/journal.pbio.3000002) (PMID:30763313) (PMCID:PMC6375548)

2018

Muvhali, P. T., Bonato, M., Engelbrecht, A., Malecki, I. A., Hough, D., Robinson, J. E. , Evans, N. P. and Cloete, S. W.P. (2018) The effect of extensive human presence at an early age on stress responses and reactivity of juvenile ostriches towards humans. Animals, 8(10), 175. (doi:10.3390/ani8100175) (PMID:30301126) (PMCID:PMC6210211)

Johnston, Z. C. et al. (2018) The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. BMC Medicine, 16, 23. (doi:10.1186/s12916-018-1009-7) (PMID:29429410) (PMCID:PMC5808459)

2017

Hough, D., Bellingham, M. , Haraldsen, J.R., McLaughlin, M. , Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep. Psychoneuroendocrinology, 77, pp. 1-8. (doi:10.1016/j.psyneuen.2016.11.029) (PMID:27987429) (PMCID:PMC5333793)

Hough, D., Bellingham, M. , Haraldsen, I.R.H., McLaughlin, M. , Rennie, M., Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep. Psychoneuroendocrinology, 75, pp. 173-182. (doi:10.1016/j.psyneuen.2016.10.016) (PMID:27837697) (PMCID:PMC5140006)

2015

Hough, D., Storbeck, K., Cloete, S.W.P., Swart, A.C. and Swart, P. (2015) Relative contribution of P450c17 towards the acute cortisol response: lessons from sheep and goats. Molecular and Cellular Endocrinology, 408, pp. 107-113. (doi:10.1016/j.mce.2015.01.018) (PMID:25597634)

2013

Hough, D., Cloete, S.W.P., Swart, P. and Cloete, J.J.E. (2013) Searching for SNPs that affect sheep robustness: CYP17 SNP affects behavioural responses to psychological stress. In: 20th Association for the Advancement of Animal Breeding and Genetics Conference, Napier, New Zealand, 20-23 Oct 2013, pp. 503-506.

Hough, D., Cloete, S.W.P., Storbeck, K., Swart, A.C. and Swart, P. (2013) Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17-alpha-hydroxylase/17,20-lyase (CYP17) isoforms. Journal of Animal Science, 91(3), pp. 1193-1206. (doi:10.2527/jas.2012-5800)

Hough, D., Swart, P. and Cloete, S. (2013) Exploration of the hypothalamic-pituitary-adrenal axis to improve animal welfare by means of genetic selection: lessons from the South African Merino. Animals, 3(2), pp. 442-474. (doi:10.3390/ani3020442) (PMID:26487412) (PMCID:PMC4494397)

2012

Cloete, A.S., Hough, D. and Cloete, S.W.P. (2012) Testing times – developing awareness while fostering research: improving health, welfare and production in South African Merinos. In: 2012 Australian and New Zealand Council for the Care of Animals in Research and Teaching Conference, Perth, W.A., Australia, 24 - 26 Jul 2012, pp. 43-48. ISBN 9780987465702

2010

Hough, D., Cloete, S.W.P., Swart, P. and Storbeck, K. (2010) Improving stress coping ability: comparison between the CYP17 genotype Of Ovis Aries and Capra Hircus. In: 9th World Congress on Genetics Applied to Livestock Production, Leipzig, Germany, 1-6 Aug 2010, 0628.

2009

Van der Walt, D., Cloete, S.W.P., Storbeck, K. and Swart, P. (2009) The role of Cytochrome P450 17-alpha-Hydroxylase/ 17,20-Lyase (CYP17) in the stress coping ability in a divergently selected Merino sheep population. In: 18th Association for the Advancement of Animal Breeding and Genetics Conference, Barossa Valley, South Australia, 28 Sep - 1 Oct 2009, pp. 100-103.

This list was generated on Sun Oct 20 23:04:17 2019 BST.
Number of items: 13.

Articles

Hough, D., Robinson, J.E. , Bellingham, M. , Fleming, L.M., McLaughlin, M. , Jama, K., Haraldsen, I.R.H., Solbakk, A.K. and Evans, N.P. (2019) Peripubertal GnRH and testosterone co-treatment leads to increased familiarity preferences in male sheep. Psychoneuroendocrinology, 108, pp. 70-77. (doi:10.1016/j.psyneuen.2019.06.008) (PMID:31229635)

O'Shaughnessy, P. J. et al. (2019) Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biology, 17(2), e3000002. (doi:10.1371/journal.pbio.3000002) (PMID:30763313) (PMCID:PMC6375548)

Muvhali, P. T., Bonato, M., Engelbrecht, A., Malecki, I. A., Hough, D., Robinson, J. E. , Evans, N. P. and Cloete, S. W.P. (2018) The effect of extensive human presence at an early age on stress responses and reactivity of juvenile ostriches towards humans. Animals, 8(10), 175. (doi:10.3390/ani8100175) (PMID:30301126) (PMCID:PMC6210211)

Johnston, Z. C. et al. (2018) The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. BMC Medicine, 16, 23. (doi:10.1186/s12916-018-1009-7) (PMID:29429410) (PMCID:PMC5808459)

Hough, D., Bellingham, M. , Haraldsen, J.R., McLaughlin, M. , Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep. Psychoneuroendocrinology, 77, pp. 1-8. (doi:10.1016/j.psyneuen.2016.11.029) (PMID:27987429) (PMCID:PMC5333793)

Hough, D., Bellingham, M. , Haraldsen, I.R.H., McLaughlin, M. , Rennie, M., Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep. Psychoneuroendocrinology, 75, pp. 173-182. (doi:10.1016/j.psyneuen.2016.10.016) (PMID:27837697) (PMCID:PMC5140006)

Hough, D., Storbeck, K., Cloete, S.W.P., Swart, A.C. and Swart, P. (2015) Relative contribution of P450c17 towards the acute cortisol response: lessons from sheep and goats. Molecular and Cellular Endocrinology, 408, pp. 107-113. (doi:10.1016/j.mce.2015.01.018) (PMID:25597634)

Hough, D., Cloete, S.W.P., Storbeck, K., Swart, A.C. and Swart, P. (2013) Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17-alpha-hydroxylase/17,20-lyase (CYP17) isoforms. Journal of Animal Science, 91(3), pp. 1193-1206. (doi:10.2527/jas.2012-5800)

Hough, D., Swart, P. and Cloete, S. (2013) Exploration of the hypothalamic-pituitary-adrenal axis to improve animal welfare by means of genetic selection: lessons from the South African Merino. Animals, 3(2), pp. 442-474. (doi:10.3390/ani3020442) (PMID:26487412) (PMCID:PMC4494397)

Conference Proceedings

Hough, D., Cloete, S.W.P., Swart, P. and Cloete, J.J.E. (2013) Searching for SNPs that affect sheep robustness: CYP17 SNP affects behavioural responses to psychological stress. In: 20th Association for the Advancement of Animal Breeding and Genetics Conference, Napier, New Zealand, 20-23 Oct 2013, pp. 503-506.

Cloete, A.S., Hough, D. and Cloete, S.W.P. (2012) Testing times – developing awareness while fostering research: improving health, welfare and production in South African Merinos. In: 2012 Australian and New Zealand Council for the Care of Animals in Research and Teaching Conference, Perth, W.A., Australia, 24 - 26 Jul 2012, pp. 43-48. ISBN 9780987465702

Hough, D., Cloete, S.W.P., Swart, P. and Storbeck, K. (2010) Improving stress coping ability: comparison between the CYP17 genotype Of Ovis Aries and Capra Hircus. In: 9th World Congress on Genetics Applied to Livestock Production, Leipzig, Germany, 1-6 Aug 2010, 0628.

Van der Walt, D., Cloete, S.W.P., Storbeck, K. and Swart, P. (2009) The role of Cytochrome P450 17-alpha-Hydroxylase/ 17,20-Lyase (CYP17) in the stress coping ability in a divergently selected Merino sheep population. In: 18th Association for the Advancement of Animal Breeding and Genetics Conference, Barossa Valley, South Australia, 28 Sep - 1 Oct 2009, pp. 100-103.

This list was generated on Sun Oct 20 23:04:17 2019 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Is the adrenal functionally altered when puberty is delayed with GnRHa?
    Society for Endocrinology
    2017 - 2017
     
  • Investigating hypothalamic mechanisms that control LH profiles in oestrous ewes from two genetically distinct lines
    British Society for Neuroendocrinology
    2017 - 2018
     

Teaching

Level 1 Biology

MRes Biomedical Sciences: Endocrinology in Health and Disease