Professor John Coggins
- Honorary Senior Research Fellow (School of Molecular Biosciences)
email:
John.Coggins@glasgow.ac.uk
Level 4, Pro-Vice Principal Office, 13 The Square, Glasgow G12 8QQ
Publications
2007
Prazeres, V. F.V., Sanchez-Sixto, C., Castedo, L., Lamb, H., Hawkins, A. R., Riboldi-Tunnicliffe, A., Coggins, J. R., Lapthorn, A. J. and Gonzalez-Bello, C. (2007) Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase. ChemMedChem, 2(2), pp. 194-207. (doi: 10.1002/cmdc.200600208)
2006
Robinson, D.A.,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R. and Lapthorn, A.J. (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49(4), pp. 1282-1290. (doi: 10.1021/jm0505361)
2005
Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J. and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi: 10.1039/B507156A)
2004
Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R. and Lapthorn, A.J. (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336(1), pp. 131-144. (doi: 10.1016/j.jmb.2003.12.020)
Campbell, S., Richards, T., Mui, E., Samuel, B., Coggins, J., McLeod, R. and Roberts, C. (2004) A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation. International Journal for Parasitology, 34(1), pp. 5-13. (doi: 10.1016/j.ijpara.2003.10.006)
Bulloch, E., Jones, M., Parker, E., Osborne, A., Stephens, E., Davies, G., Coggins, J. and Abell, C. (2004) Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate. Journal of the American Chemical Society, 126, pp. 9912-9913. (doi: 10.1021/ja048312f)
Frederickson, M., Roszak, A.W., Coggins, J.R., Lapthorn, A.J. and Abell, C. (2004) (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2, pp. 1592-1596. (doi: 10.1039/b404535a)
Frederickson, M., Roszak, A. W., Coggins, J. R., Lapthorn, A. J. and Abell, C. (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi: 10.1039/B404535A)
2003
Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W. and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.
Cerasoli, E., Kelly, S.M. , Coggins, J.R., Lapthorn, A.J. , Clarke, D.T. and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648(1-2), pp. 43-54. (doi: 10.1016/S1570-9639(03)00110-9)
Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi: 10.1074/jbc.M300794200)
Brown, K., Carpenter, E., Watson, K., Coggins, J., Hawkins, A., Koch, M. and Svergun, D. (2003) Twists and turns: a tale of two shikimate-pathway enzymes. Biochemical Society Transactions, 31, pp. 543-547.
Frederickson, M., Parker, E., Coggins, J. and Abell, C. (2003) Enzymic synthesis of 3-[3-C-13]dehydroquinic acid. Organic and Biomolecular Chemistry, 1, pp. 3271-3273. (doi: 10.1039/b309666a)
Gonzalez-Bello, C., Lence, E., Toscano, M., Castedo, L., Coggins, J. and Abell, C. (2003) Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase. Journal of Medicinal Chemistry, 46, pp. 5735-5744. (doi: 10.1021/jm030987q)
Toscano, M., Frederickson, M., Evans, D., Coggins, J., Abell, C. and Gonzalez-Bello, C. (2003) Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 1, pp. 2075-2083. (doi: 10.1039/b301731a)
2002
Evans, L. D.B., Roszak, A. W., Noble, L. J., Robinson, D. A., Chalk, P. A., Matthews, J. L., Coggins, J. R., Price, N. C. and Lapthorn, A. J. (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530(1-3), pp. 24-30. (doi: 10.1016/S0014-5793(02)03346-X)
Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R. and Lapthorn, A.J. (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10(4), pp. 493-503. (doi: 10.1016/S0969-2126(02)00747-5)
Frederickson, M., Coggins, J. and Abell, C. (2002) Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases. Chemical Communications, pp. 1886-1887. (doi: 10.1039/b205105m)
Roberts, C. et al. (2002) The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases, 185, S25-S36.
Watts, C., Si-Hoe, S.M., Lamb, H.K., Levett, L.J., Coggins, J.R. and Hawkins, A.R. (2002) Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins. Proteins: Structure Function and Genetics, 48, pp. 161-168. (doi: 10.1002/prot.10157)
2001
Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J. and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10(6), pp. 1137-1149. (doi: 10.1110/ps.52501)
2000
Maclean, J., Campbell, S. A., Pollock, K., Chackrewarthy, S., Coggins, J. R. and Lapthorn, A. J. (2000) Crystallization and preliminary X-ray analysis of shikimate dehydrogenase fromEscherichia coli. Acta Crystallographica. Section D: Biological Crystallography, 56(4), pp. 512-515. (doi: 10.1107/S0907444900002377)
1998
Krell, T., Coggins, J. R. and Lapthorn, A. J. (1998) The three-dimensional structure of shikimate kinase. Journal of Molecular Biology, 278(5), pp. 983-997. (doi: 10.1006/jmbi.1998.1755) (PMID:9600856)
1997
Idziak, C., Price, N. C., Kelly, S. M., Krell, T., Boam, D. J., Lapthorn, A. J. and Coggins, J. R. (1997) 93 The interaction of shikimate kinase fromErwinia chrystanthemiwith substrates. Biochemical Society Transactions, 25(4), S627-S627. (doi: 10.1042/bst025s627)
Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R. and Lapthorn, A. J. (1997) Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi. Acta Crystallographica. Section D: Biological Crystallography, 53(5), pp. 612-614. (doi: 10.1107/S0907444997004319)
1996
Walker, G. E., Dunbar, B., Hunter, I. S., Nimmo, H. G. and Coggins, J. R. (1996) Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa. Microbiology, 142(8), pp. 1973-1982. (doi: 10.1099/13500872-142-8-1973) (PMID:8760910)
Bramwell, H., Hunter, I. S., Coggins, J. R. and Nimmo, H. G. (1996) Propionyl-CoA carboxylase from Streptomyces coelicolor A3(2): cloning of the gene encoding the biotin-containing subunit. Microbiology, 142(3), pp. 649-655. (doi: 10.1099/13500872-142-3-649) (PMID:8868440)
1995
Walker, G.E., Dunbar, B., Hunter, I. S., Nimmo, H. G. and Coggins, J. R. (1995) A catalase from Streptomyces coelicolor A3(2). Microbiology, 141(6), pp. 1377-1383. (doi: 10.1099/13500872-141-6-1377) (PMID:7670639)
1993
Bramwell, H., Nimmo, H.G. , Hunter, I.S. and Coggins, J.R. (1993) Phosphoenolpyruvate carboxylase from Streptomyces coelicolor A3(2): purification of the enzyme, cloning of the ppc gene and over-expression of the protein in a streptomycete. Biochemical Journal, 293(1), pp. 131-136. (doi: 10.1042/bj2930131) (PMID:8328954) (PMCID:PMC1134330)
1992
White, P.J., Nairn, J., Price, N.C., Nimmo, H.G. , Coggins, J.R. and Hunter, I.S. (1992) Phosphoglycerate mutase from Streptomyces coelicolor A3(2): Purification and characterization of the enzyme and cloning and sequence analysis of the gene. Journal of Bacteriology, 174(2), pp. 434-440. (doi: 10.1128/jb.174.2.434-440.1992) (PMID:1530847) (PMCID:PMC205734)
1990
White, P.J., Young, J., Hunter, I.S., Nimmo, H.G. and Coggins, J.R. (1990) The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor. Biochemical Journal, 265(3), pp. 735-738. (doi: 10.1042/bj2650735) (PMID:2306211) (PMCID:PMC1133695)
Articles
Prazeres, V. F.V., Sanchez-Sixto, C., Castedo, L., Lamb, H., Hawkins, A. R., Riboldi-Tunnicliffe, A., Coggins, J. R., Lapthorn, A. J. and Gonzalez-Bello, C. (2007) Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase. ChemMedChem, 2(2), pp. 194-207. (doi: 10.1002/cmdc.200600208)
Robinson, D.A.,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R. and Lapthorn, A.J. (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49(4), pp. 1282-1290. (doi: 10.1021/jm0505361)
Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J. and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi: 10.1039/B507156A)
Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R. and Lapthorn, A.J. (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336(1), pp. 131-144. (doi: 10.1016/j.jmb.2003.12.020)
Campbell, S., Richards, T., Mui, E., Samuel, B., Coggins, J., McLeod, R. and Roberts, C. (2004) A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation. International Journal for Parasitology, 34(1), pp. 5-13. (doi: 10.1016/j.ijpara.2003.10.006)
Bulloch, E., Jones, M., Parker, E., Osborne, A., Stephens, E., Davies, G., Coggins, J. and Abell, C. (2004) Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate. Journal of the American Chemical Society, 126, pp. 9912-9913. (doi: 10.1021/ja048312f)
Frederickson, M., Roszak, A.W., Coggins, J.R., Lapthorn, A.J. and Abell, C. (2004) (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2, pp. 1592-1596. (doi: 10.1039/b404535a)
Frederickson, M., Roszak, A. W., Coggins, J. R., Lapthorn, A. J. and Abell, C. (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi: 10.1039/B404535A)
Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W. and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.
Cerasoli, E., Kelly, S.M. , Coggins, J.R., Lapthorn, A.J. , Clarke, D.T. and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648(1-2), pp. 43-54. (doi: 10.1016/S1570-9639(03)00110-9)
Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi: 10.1074/jbc.M300794200)
Brown, K., Carpenter, E., Watson, K., Coggins, J., Hawkins, A., Koch, M. and Svergun, D. (2003) Twists and turns: a tale of two shikimate-pathway enzymes. Biochemical Society Transactions, 31, pp. 543-547.
Frederickson, M., Parker, E., Coggins, J. and Abell, C. (2003) Enzymic synthesis of 3-[3-C-13]dehydroquinic acid. Organic and Biomolecular Chemistry, 1, pp. 3271-3273. (doi: 10.1039/b309666a)
Gonzalez-Bello, C., Lence, E., Toscano, M., Castedo, L., Coggins, J. and Abell, C. (2003) Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase. Journal of Medicinal Chemistry, 46, pp. 5735-5744. (doi: 10.1021/jm030987q)
Toscano, M., Frederickson, M., Evans, D., Coggins, J., Abell, C. and Gonzalez-Bello, C. (2003) Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 1, pp. 2075-2083. (doi: 10.1039/b301731a)
Evans, L. D.B., Roszak, A. W., Noble, L. J., Robinson, D. A., Chalk, P. A., Matthews, J. L., Coggins, J. R., Price, N. C. and Lapthorn, A. J. (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530(1-3), pp. 24-30. (doi: 10.1016/S0014-5793(02)03346-X)
Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R. and Lapthorn, A.J. (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10(4), pp. 493-503. (doi: 10.1016/S0969-2126(02)00747-5)
Frederickson, M., Coggins, J. and Abell, C. (2002) Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases. Chemical Communications, pp. 1886-1887. (doi: 10.1039/b205105m)
Roberts, C. et al. (2002) The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases, 185, S25-S36.
Watts, C., Si-Hoe, S.M., Lamb, H.K., Levett, L.J., Coggins, J.R. and Hawkins, A.R. (2002) Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins. Proteins: Structure Function and Genetics, 48, pp. 161-168. (doi: 10.1002/prot.10157)
Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J. and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10(6), pp. 1137-1149. (doi: 10.1110/ps.52501)
Maclean, J., Campbell, S. A., Pollock, K., Chackrewarthy, S., Coggins, J. R. and Lapthorn, A. J. (2000) Crystallization and preliminary X-ray analysis of shikimate dehydrogenase fromEscherichia coli. Acta Crystallographica. Section D: Biological Crystallography, 56(4), pp. 512-515. (doi: 10.1107/S0907444900002377)
Krell, T., Coggins, J. R. and Lapthorn, A. J. (1998) The three-dimensional structure of shikimate kinase. Journal of Molecular Biology, 278(5), pp. 983-997. (doi: 10.1006/jmbi.1998.1755) (PMID:9600856)
Idziak, C., Price, N. C., Kelly, S. M., Krell, T., Boam, D. J., Lapthorn, A. J. and Coggins, J. R. (1997) 93 The interaction of shikimate kinase fromErwinia chrystanthemiwith substrates. Biochemical Society Transactions, 25(4), S627-S627. (doi: 10.1042/bst025s627)
Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R. and Lapthorn, A. J. (1997) Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi. Acta Crystallographica. Section D: Biological Crystallography, 53(5), pp. 612-614. (doi: 10.1107/S0907444997004319)
Walker, G. E., Dunbar, B., Hunter, I. S., Nimmo, H. G. and Coggins, J. R. (1996) Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa. Microbiology, 142(8), pp. 1973-1982. (doi: 10.1099/13500872-142-8-1973) (PMID:8760910)
Bramwell, H., Hunter, I. S., Coggins, J. R. and Nimmo, H. G. (1996) Propionyl-CoA carboxylase from Streptomyces coelicolor A3(2): cloning of the gene encoding the biotin-containing subunit. Microbiology, 142(3), pp. 649-655. (doi: 10.1099/13500872-142-3-649) (PMID:8868440)
Walker, G.E., Dunbar, B., Hunter, I. S., Nimmo, H. G. and Coggins, J. R. (1995) A catalase from Streptomyces coelicolor A3(2). Microbiology, 141(6), pp. 1377-1383. (doi: 10.1099/13500872-141-6-1377) (PMID:7670639)
Bramwell, H., Nimmo, H.G. , Hunter, I.S. and Coggins, J.R. (1993) Phosphoenolpyruvate carboxylase from Streptomyces coelicolor A3(2): purification of the enzyme, cloning of the ppc gene and over-expression of the protein in a streptomycete. Biochemical Journal, 293(1), pp. 131-136. (doi: 10.1042/bj2930131) (PMID:8328954) (PMCID:PMC1134330)
White, P.J., Nairn, J., Price, N.C., Nimmo, H.G. , Coggins, J.R. and Hunter, I.S. (1992) Phosphoglycerate mutase from Streptomyces coelicolor A3(2): Purification and characterization of the enzyme and cloning and sequence analysis of the gene. Journal of Bacteriology, 174(2), pp. 434-440. (doi: 10.1128/jb.174.2.434-440.1992) (PMID:1530847) (PMCID:PMC205734)
White, P.J., Young, J., Hunter, I.S., Nimmo, H.G. and Coggins, J.R. (1990) The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor. Biochemical Journal, 265(3), pp. 735-738. (doi: 10.1042/bj2650735) (PMID:2306211) (PMCID:PMC1133695)