Dr Suzannah Rihn
- Senior Research Fellow (Virology)
telephone:
0141 330 4913
email:
Suzannah.Rihn@glasgow.ac.uk
RI Infection Immunity and Inflam, CVR Garscube, 464 Bearsden Road, Sir Michael Stoker Building (SMSB), Level 4, G61 1qh
https://orcid.org/0000-0001-9495-4056Research interests
My research investigates the robustness of viruses, with a focus on HIV-1. In addition to trying to identify novel immune challenges that HIV-1 may face, we examine how the virus navigates between divergent needs to both conserve fitness and function but to also overcome diverse and fluctuating immune and environmental pressures
Publications
2022
Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)
2021
Khan, H. et al. (2021) TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction. PLoS Pathogens, 17(11), e1009820. (doi: 10.1371/journal.ppat.1009820) (PMID:34807954) (PMCID:PMC8648102)
Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)
Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
2020
Gordon, D. E. et al. (2020) Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521), eabe9403. (doi: 10.1126/science.abe9403) (PMID:33060197) (PMCID:PMC7808408)
Banerjee, A. K. et al. (2020) SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cell, (doi: 10.1016/j.cell.2020.10.004) (PMID:33080218) (PMCID:PMC7543886)
2019
Rihn, S. J. et al. (2019) TRIM69 inhibits vesicular stomatitis Indiana virus (VSIV). Journal of Virology, 93(20), e00951-19. (doi: 10.1128/JVI.00951-19) (PMID:31375575)
2018
Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi: 10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)
2017
Rihn, S. J. , Foster, T. L., Busnadiego, I., Aziz, M. A. B., Hughes, J. , Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi: 10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)
2016
Kane, M., Zang, T. M., Rihn, S. J. , Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi: 10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)
2015
Rihn, S. J. , Hughes, J. , Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi: 10.1128/JVI.02451-14)
2014
Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi: 10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)
2013
Rihn, S.J. , Wilson, S.J. , Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. , Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi: 10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)
2012
Meredith, M.M. et al. (2012) Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. Journal of Experimental Medicine, 209(9), pp. 1583-1593. (doi: 10.1084/jem.20121003) (PMID:22851594) (PMCID:PMC3428942))
2011
Alter, G., Jost, S., Rihn, S. , Reyor, L. L., Nolan, B. E., Ghebremichael, M., Bosch, R., Altfeld, M. and Lauer, G. M. (2011) Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. Journal of Hepatology, 55(2), pp. 278-288. (doi: 10.1016/j.jhep.2010.11.030) (PMID:21168454) (PMCID:PMC3729214)
2010
Nolting, A. et al. (2010) MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology, 406(1), pp. 12-20. (doi: 10.1016/j.virol.2010.05.014) (PMID:20667578) (PMCID:MC2932841)
Alter, G., Kavanagh, D., Rihn, S. , Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J. and Altfeld, M. (2010) IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. Journal of Clinical Investigation, 120(6), pp. 1905-1913. (doi: 10.1172/JCI40913) (PMID:20440075) (PMCID:PMC2877944)
2009
Liu, Q., Sun, Y., Rihn, S. , Nolting, A., Tsoukas, P.N., Jost, S., Cohen, K., Walker, B. and Alter, G. (2009) Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. Journal of Virology, 83(17), pp. 8705-8712. (doi: 10.1128/JVI.02666-08) (PMID:19553339) (PMCID:PMC2738177)
Alter, G., Rihn, S. , Walter, K., Nolting, A., Martin, M., Rosenberg, E. S., Miller, J. S., Carrington, M. and Altfeld, M. (2009) HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection. Journal of Virology, 83(13), pp. 6798-6805. (doi: 10.1128/JVI.00256-09) (PMID:19386717) (PMCID:PMC2698561)
2008
Alter, G. et al. (2008) Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T Cells in human immunodeficiency virus Type 1 infection. Journal of Virology, 82(19), pp. 9668-9677. (doi: 10.1128/JVI.00341-08) (PMID:18579582) (PMCID:PMC2546972)
Articles
Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)
Khan, H. et al. (2021) TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction. PLoS Pathogens, 17(11), e1009820. (doi: 10.1371/journal.ppat.1009820) (PMID:34807954) (PMCID:PMC8648102)
Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)
Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Gordon, D. E. et al. (2020) Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521), eabe9403. (doi: 10.1126/science.abe9403) (PMID:33060197) (PMCID:PMC7808408)
Banerjee, A. K. et al. (2020) SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cell, (doi: 10.1016/j.cell.2020.10.004) (PMID:33080218) (PMCID:PMC7543886)
Rihn, S. J. et al. (2019) TRIM69 inhibits vesicular stomatitis Indiana virus (VSIV). Journal of Virology, 93(20), e00951-19. (doi: 10.1128/JVI.00951-19) (PMID:31375575)
Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi: 10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)
Rihn, S. J. , Foster, T. L., Busnadiego, I., Aziz, M. A. B., Hughes, J. , Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi: 10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)
Kane, M., Zang, T. M., Rihn, S. J. , Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi: 10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)
Rihn, S. J. , Hughes, J. , Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi: 10.1128/JVI.02451-14)
Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi: 10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)
Rihn, S.J. , Wilson, S.J. , Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. , Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi: 10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)
Meredith, M.M. et al. (2012) Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. Journal of Experimental Medicine, 209(9), pp. 1583-1593. (doi: 10.1084/jem.20121003) (PMID:22851594) (PMCID:PMC3428942))
Alter, G., Jost, S., Rihn, S. , Reyor, L. L., Nolan, B. E., Ghebremichael, M., Bosch, R., Altfeld, M. and Lauer, G. M. (2011) Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. Journal of Hepatology, 55(2), pp. 278-288. (doi: 10.1016/j.jhep.2010.11.030) (PMID:21168454) (PMCID:PMC3729214)
Nolting, A. et al. (2010) MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology, 406(1), pp. 12-20. (doi: 10.1016/j.virol.2010.05.014) (PMID:20667578) (PMCID:MC2932841)
Alter, G., Kavanagh, D., Rihn, S. , Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J. and Altfeld, M. (2010) IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. Journal of Clinical Investigation, 120(6), pp. 1905-1913. (doi: 10.1172/JCI40913) (PMID:20440075) (PMCID:PMC2877944)
Liu, Q., Sun, Y., Rihn, S. , Nolting, A., Tsoukas, P.N., Jost, S., Cohen, K., Walker, B. and Alter, G. (2009) Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. Journal of Virology, 83(17), pp. 8705-8712. (doi: 10.1128/JVI.02666-08) (PMID:19553339) (PMCID:PMC2738177)
Alter, G., Rihn, S. , Walter, K., Nolting, A., Martin, M., Rosenberg, E. S., Miller, J. S., Carrington, M. and Altfeld, M. (2009) HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection. Journal of Virology, 83(13), pp. 6798-6805. (doi: 10.1128/JVI.00256-09) (PMID:19386717) (PMCID:PMC2698561)
Alter, G. et al. (2008) Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T Cells in human immunodeficiency virus Type 1 infection. Journal of Virology, 82(19), pp. 9668-9677. (doi: 10.1128/JVI.00341-08) (PMID:18579582) (PMCID:PMC2546972)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Identifying the Host and Viral Determinants of Coronavirus Emergence and Adaptation in Human Populations
Medical Research Council
2020 - 2023
- Host and Viral Determinants of Interferon Resistance During HIV-1 Transmission
Medical Research Council
2018 - 2020
- The role of ISGs in HIV-1 transmision
Medical Research Council
2018 - 2020
- Inhibition of HIV-1 by Type II Interferon
Wellcome Trust
2017 - 2021
Research datasets
2022
Sugrue, E. , Wickenhagen, A., Mollentze, N. , Aziz, M. A., Sreenu, V. B., Truxa, S., Tong, L., Da Silva Filipe, A. , Robertson, D. , Hughes, J. , Rihn, S. and Wilson, S. (2022) The Interferon Resistance of Transmitted HIV-1 is Possibly a Consequence of Enhanced Replicative Fitness. [Data Collection]
2021
Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]
Shaw, A., Rihn, S. , Mollentze, N. , Wickenhagen, A., Stewart, D., Orton, R. , Kuchi, S., Bakshi, S., Collados Rodriguez, M. , Turnbull, M. , Busby, J. , Gu, Q. , Smollett, K., Bamford, C., Sugrue, E. , Johnson, P. , Da Silva Filipe, A. , Castello, A. , Streicker, D. , Robertson, D. , Palmarini, M. and Wilson, S. (2021) The 'antiviral state' has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. [Data Collection] (Unpublished)
