Professor Matthew Cotten
- Professor in Viral Genomics (Virology)
Publications
2023
Cotten, M. and Phan, M. V.T. (2023) Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission. iScience, 26(3), 106230. (doi: 10.1016/j.isci.2023.106230) (PMID:36845032) (PMCID:PMC9937996)
2022
Tegally, H. et al. (2022) The evolving SARS-CoV-2 epidemic in Africa: insights from rapidly expanding genomic surveillance. Science, 378(6615), eabq5358. (doi: 10.1126/science.abq5358) (PMID:36108049) (PMCID:PMC9529057)
Kwok, K. T. T. , de Rooij, M. M. T., Messink, A. B., Wouters, I. M., Smit, L. A. M., Cotten, M. , Heederik, D. J. J., Koopmans, M. P. G. and Phan, M. V. T. (2022) Establishing farm dust as a useful viral metagenomic surveillance matrix. Scientific Reports, 12, 16308. (doi: 10.1038/s41598-022-20701-x) (PMID:36175536) (PMCID:PMC9521564)
Lubinski, B., Frazier, L. E., Phan, M. V. T., Bugembe, D. L., Cunningham, J. L., Tang, T., Daniel, S., Cotten, M. , Jaimes, J. A. and Whittaker, G. R. (2022) Spike protein cleavage-activation in the context of the SARS-CoV-2 P681R mutation: an analysis from its first appearance in lineage A.23.1 identified in Uganda. Microbiology Spectrum, 10(4), e0151422. (doi: 10.1128/spectrum.01514-22) (PMID:35766497)
Namuwulya, P., Bukenya, H., Tushabe, P., Tweyongyere, R., Bwogi, J., Cotten, M. and Phan, M. V. T. (2022) Near-complete genome sequences of measles virus strains from 10 years of Uganda country-wide surveillance. Microbiology Resource Announcements, 11(8), e0060622. (doi: 10.1128/mra.00606-22) (PMID:35876572) (PMCID:PMC9387275)
Agoti, C. N. et al. (2022) Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: a retrospective genomic study. eLife, 11, e71703. (doi: 10.7554/elife.71703) (PMID:35699426) (PMCID:PMC9282859)
Phan, M. V. T., Agoti, C. N., Munywoki, P. K., Otieno, G. P., Ngama, M., Kellam, P., Cotten, M. and Nokes, D. J. (2022) Identification of missed viruses by metagenomic sequencing of clinical respiratory samples from Kenya. Scientific Reports, 12(1), 202. (doi: 10.1038/s41598-021-03987-1) (PMID:34997042) (PMCID:PMC8742071)
2021
Lutalo, T. et al. (2021) Evaluation of the performance of 25 SARS-CoV-2 serological rapid diagnostic tests using a reference panel of plasma specimens at the Uganda Virus Research Institute. International Journal of Infectious Diseases, 112, pp. 281-287. (doi: 10.1016/j.ijid.2021.09.020) (PMID:34536612) (PMCID:PMC8442260)
Wilkinson, E. et al. (2021) A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa. Science, 374(6566), pp. 423-431. (doi: 10.1126/science.abj4336)
Cotten, M. , Robertson, D. L. and Phan, M. V.T. (2021) Unique protein features of SARS-CoV-2 relative to other Sarbecoviruses. Virus Evolution, 7(2), veab067. (doi: 10.1093/ve/veab067) (PMID:34527286) (PMCID:PMC8385934)
Bugembe, D. L. et al. (2021) Emergence and spread of a SARS-CoV-2 lineage A variant (A.23.1) with altered spike protein in Uganda. Nature Microbiology, 6(8), pp. 1094-1101. (doi: 10.1038/s41564-021-00933-9) (PMID:34163035) (PMCID:PMC8318884)
Roach, M. et al. (2021) No evidence known viruses play a role in the pathogenesis of onchocerciasis-associated epilepsy. An explorative metagenomic case-control study. Pathogens, 10(7), 787. (doi: 10.3390/pathogens10070787) (PMID:34206564) (PMCID:PMC8308762)
Lambisia, A. W., Phan, M. V. T., de Laurent, Z. R., Cotten, M. , Nokes, D. J., Agoti, C. N. and Matthijnssens, J. (2021) Near-complete genome sequences of eight human astroviruses recovered from diarrheal stool samples of hospitalized children in coastal Kenya in 2019. Microbiology Resource Announcements, 10(15), e00162-21. (doi: 10.1128/MRA.00162-21) (PMID:33858926) (PMCID:PMC8050968)
Allesøe, R. L., Lemvigh, C. K., Phan, M. V.T., Clausen, P. T. L.C., Florensa, A. F., Koopmans, M. P.G., Lund, O. and Cotten, M. (2021) Automated download and clean-up of family-specific databases for kmer-based virus identification. Bioinformatics, 37(5), pp. 705-710. (doi: 10.1093/bioinformatics/btaa857) (PMID:33031509) (PMCID:PMC8097684)
Nalumansi, A. et al. (2021) Field evaluation of the performance of a SARS-CoV-2 antigen rapid diagnostic test in Uganda using nasopharyngeal samples. International Journal of Infectious Diseases, 104, pp. 282-286. (doi: 10.1016/j.ijid.2020.10.073) (PMID:33130198) (PMCID:PMC7836828)
Kapaata, A. et al. (2021) HIV-1 Gag-Pol sequences from Ugandan early infections reveal sequence variants associated with elevated replication capacity. Viruses, 13(2), 171. (doi: 10.3390/v13020171) (PMID:33498793) (PMCID:PMC7912664)
Cotten, M. , Bugembe, D. L., Kaleebu, P. and Phan, M. V.T. (2021) Alternate primers for whole-genome SARS-CoV-2 sequencing. Virus Evolution, 7(1), veab006. (doi: 10.1093/ve/veab006) (PMID:33841912) (PMCID:PMC7928614)
2020
Bugembe, D. L. et al. (2020) Main routes of entry and genomic diversity of SARS-CoV-2, Uganda. Emerging Infectious Diseases, 26(10), pp. 2411-2415. (doi: 10.3201/eid2610.202575) (PMID:32614767) (PMCID:PMC7510740)
Kinsella, C. M., Bart, A., Deijs, M., Broekhuizen, P., Kaczorowska, J., Jebbink, M. F., van Gool, T., Cotten, M. and van der Hoek, L. (2020) Entamoeba and Giardia parasites implicated as hosts of CRESS viruses. Nature Communications, 11, 4620. (doi: 10.1038/s41467-020-18474-w) (PMID:32934242) (PMCID:PMC7493932)
Barry, M. et al. (2020) Nosocomial outbreak of the Middle East Respiratory Syndrome coronavirus: a phylogenetic, epidemiological, clinical and infection control analysis. Travel Medicine and Infectious Disease, 37, 101807. (doi: 10.1016/j.tmaid.2020.101807) (PMID:32599173) (PMCID:PMC7319941)
Nieuwenhuijse, D. F. et al. (2020) Setting a baseline for global urban virome surveillance in sewage. Scientific Reports, 10, 13748. (doi: 10.1038/s41598-020-69869-0) (PMID:32792677) (PMCID:PMC7426863)
Masembe, C. , Phan, M. V.T., Robertson, D. L. and Cotten, M. (2020) Increased resolution of African swine fever virus genome patterns based on profile HMMs of protein domains. Virus Evolution, 6(2), veaa044. (doi: 10.1093/ve/veaa044) (PMID:32913663) (PMCID:PMC7474929)
Phan, M. V.T., Mendonca Melo, M., van Nood, E., Aron, G., Kreeft-Voermans, J. J.C., Koopmans, M. P.G., Reusken, C., GeurtsvanKessel, C. H. and Cotten, M. (2020) Shedding of yellow fever virus from an imported case in the Netherlands after travel to Brazil. Open Forum Infectious Diseases, 7(2), ofaa020. (doi: 10.1093/ofid/ofaa020) (PMID:32055637) (PMCID:PMC7008093)
2019
Amid, C. et al. (2019) The COMPARE Data Hubs. Database, 2019, baz136. (doi: 10.1093/database/baz136) (PMID:31868882) (PMCID:PMC6927095)
Strubbia, S., Phan, M. V.T., Schaeffer, J., Koopmans, M., Cotten, M. and Le Guyader, F. S. (2019) Characterization of Norovirus and other human enteric viruses in sewage and stool samples through next-generation sequencing. Food and Environmental Virology, 11(4), pp. 400-409. (doi: 10.1007/s12560-019-09402-3) (PMID:31446609) (PMCID:PMC6848244)
Agoti, C. N., Phan, M. V.T., Munywoki, P. K., Githinji, G., Medley, G. F., Cane, P. A., Kellam, P., Cotten, M. and Nokes, D. J. (2019) Genomic analysis of respiratory syncytial virus infections in households and utility in inferring who infects the infant. Scientific Reports, 9(1), 10076. (doi: 10.1038/s41598-019-46509-w) (PMID:31296922) (PMCID:PMC6624209)
Tapinos, A., Constantinides, B., Phan, M. V. T., Kouchaki, S., Cotten, M. and Robertson, D. L. (2019) The utility of data transformation for alignment, de novo assembly and classification of short read virus sequences. Viruses, 11(5), 394. (doi: 10.3390/v11050394) (PMID:31035503) (PMCID:PMC6563281)
Canuti, M., Williams, C. V., Sagan, S. M., Oude Munnink, B. B., Gadi, S., Verhoeven, J. T. P., Kellam, P. and Cotten, M. (2019) Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs. Archives of Virology, 164(2), pp. 509-522. (doi: 10.1007/s00705-018-4099-9) (PMID:30460488)
Phan, M. V.T., Arron, G., Geurts van Kessel, C. H., Hulsman, R. C., Molenkamp, R., Koopmans, M. P.G. and Cotten, M. (2019) Complete genome characterization of eight human parainfluenza viruses from the Netherlands. Microbiology Resource Announcements, 8(15), e00125-19. (doi: 10.1128/MRA.00125-19) (PMID:30975805) (PMCID:PMC6460028)
2018
Said Mohammed, K., Kibinge, N., Prins, P., Agoti, C. N., Cotten, M. , Nokes, D.J., Brand, S. and Githinji, G. (2018) Evaluating the performance of tools used to call minority variants from whole genome short-read data. Wellcome Open Research, 3, 21. (doi: 10.12688/wellcomeopenres.13538.2) (PMID:30483597) (PMCID:PMC6234735)
Otieno, J.R. et al. (2018) Whole genome analysis of local Kenyan and global sequences unravels the epidemiological and molecular evolutionary dynamics of RSV genotype ON1 strains. Virus Evolution, 4(2), vey027. (doi: 10.1093/ve/vey027) (PMID:30271623) (PMCID:PMC6153471)
Phan, M. V.T., Tri, T. N., Anh, P. H., Baker, S., VIZIONS Consortium, , Kellam, P. and Cotten, M. (2018) Identification and characterization of Coronaviridae genomes from Vietnamese bats and rats based on conserved protein domains. Virus Evolution, 4(2), vey035. (doi: 10.1093/ve/vey035) (PMID:30568804) (PMCID:PMC6295324)
Kiyuka, P. K. et al. (2018) Human coronavirus NL63 molecular epidemiology and evolutionary patterns in rural coastal Kenya. Journal of Infectious Diseases, 217(11), pp. 1728-1739. (doi: 10.1093/infdis/jiy098) (PMID:29741740) (PMCID:PMC6037089)
My, V. V.T., Schapendonk, C. M.E., Oude Munnink, B. B., Koopmans, M. P.G., de Swart, R. L. and Cotten, M. (2018) Complete genome sequences of six measles virus strains. Genome Announcements, 6(13), e00184-18. (doi: 10.1128/genomea.00184-18) (PMID:29599155) (PMCID:PMC5876482)
de Silva, T. I. et al. (2018) HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 32(6), pp. 709-714. (doi: 10.1097/QAD.0000000000001753) (PMID:29369160) (PMCID:PMC5895130)
Berto, A. et al. (2018) Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam. Zoonoses and Public Health, 65(1), pp. 30-42. (doi: 10.1111/zph.12362) (PMID:28418192) (PMCID:PMC5811810)
Berto, A. et al. (2018) Hepatitis E in southern Vietnam: seroepidemiology in humans and molecular epidemiology in pigs. Zoonoses and Public Health, 65(1), pp. 43-50. (doi: 10.1111/zph.12364) (PMID:28598034) (PMCID:PMC6645987)
2017
Oude Munnink, B. B., Phan, M. V.T., The VIZIONS Consortium, , Simmonds, P., Koopmans, M. P.G., Kellam, P., van der Hoek, L. and Cotten, M. (2017) Characterization of Posa and Posa-like virus genomes in fecal samples from humans, pigs, rats, and bats collected from a single location in Vietnam. Virus Evolution, 3(2), vex002. (doi: 10.1093/ve/vex022) (PMID:28948041) (PMCID:PMC5597861)
Dudas, G. et al. (2017) Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature, 544(7650), pp. 309-315. (doi: 10.1038/nature22040) (PMID:28405027) (PMCID:PMC5712493)
Dolle, D. D., Liu, Z., Cotten, M. , Simpson, J. T., Iqbal, Z., Durbin, R., McCarthy, S. A. and Jeabe, T. M. (2017) Using reference-free compressed data structures to analyze sequencing reads from thousands of human genomes. Genome Research, 27(2), pp. 300-309. (doi: 10.1101/gr.211748.116) (PMID:27986821) (PMCID:PMC5287235)
Agoti, C. N. et al. (2017) Transmission patterns and evolution of respiratory syncytial virus in a community outbreak identified by genomic analysis. Virus Evolution, 3(1), vex006. (doi: 10.1093/ve/vex006) (PMID:28458916) (PMCID:PMC5399923)
2016
Fraaij, P.L.A. et al. (2016) Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016. European Communicable Disease Bulletin, 21(48), pii: 30416. (doi: 10.2807/1560-7917.es.2016.21.48.30416) (PMID:27934581) (PMCID:PMC5388114)
Cotten, M. and Koopmans, M. (2016) Next-generation sequencing and norovirus. Future Virology, 11(11), pp. 719-722. (doi: 10.2217/fvl-2016-0099) (PMID:28757893)
Diallo, B. et al. (2016) Resurgence of ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days. Clinical Infectious Diseases, 63(10), pp. 1353-1356. (doi: 10.1093/cid/ciw601) (PMID:27585800) (PMCID:PMC5091350)
Zumla, A., Alagaili, A. N., Cotten, M. and Azhar, E. I. (2016) Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East Respiratory syndrome coronavirus (MERS-CoV). BMC Medicine, 14, 132. (doi: 10.1186/s12916-016-0686-3) (PMID:27604081) (PMCID:PMC5015245)
Agoti, C. N., Kiyuka, P. K., Kamau, E., Munywoki, P. K., Bett, A., van der Hoek, L., Kellam, P., Nokes, D. J. and Cotten, M. (2016) Human rhinovirus B and C genomes from rural coastal Kenya. Genome Announcements, 4(4), e00751-16. (doi: 10.1128/genomeA.00751-16) (PMID:27469941) (PMCID:PMC4966474)
Phan, M. V. T. et al. (2016) Unbiased whole-genome deep sequencing of human and porcine stool samples reveals circulation of multiple groups of rotaviruses and a putative zoonotic infection. Virus Evolution, 2(2), vew027. (doi: 10.1093/ve/vew027) (PMID:28748110) (PMCID:PMC5522372)
Zumla, A. et al. (2016) Taking forward a 'One Health' approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential. International Journal of Infectious Diseases, 47, pp. 5-9. (doi: 10.1016/j.ijid.2016.06.012) (PMID:27321961)
Zumla, A., Goodfellow, I., Kasolo, F., Ntoumi, F., Buchy, P., Bates, M., Azhar, E. I., Cotten, M. and Petersen, E. (2016) Zika virus outbreak and the case for building effective and sustainable rapid diagnostics laboratory capacity globally. International Journal of Infectious Diseases, 45, pp. 92-94. (doi: 10.1016/j.ijid.2016.02.1007) (PMID:26952389)
Arias, A. et al. (2016) Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases. Virus Evolution, 2(1), vew016. (doi: 10.1093/ve/vew016) (PMID:28694998) (PMCID:PMC5499387)
Oude Munnink, B. B. et al. (2016) A novel astrovirus-like RNA virus detected in human stool. Virus Evolution, 2(1), vew005. (doi: 10.1093/ve/vew005) (PMID:27774298) (PMCID:PMC4989881)
Oude Munnink, B. B., Phan, M. V.T., Kellam, P., Cotten, M. and VIZIONS Consortium, (2016) Complete genome characterization of two wild-type measles viruses from Vietnamese infants during the 2014 outbreak. Genome Announcements, 4(2), e00250-16. (doi: 10.1128/genomea.00250-16) (PMID:27081130) (PMCID:PMC4832158)
Oude Munnink, B. B., Phan, M. V.T., van der Hoek, L., Kellam, P., Cotten, M. and VIZIONS Consortium, (2016) Genome sequences of a novel Vietnamese bat bunyavirus. Genome Announcements, 4(6), e01366-16. (doi: 10.1128/genomea.01366-16) (PMID:28007850) (PMCID:PMC5180378)
2015
Rabaa, M. A. et al. (2015) The Vietnam Initiative on Zoonotic Infections (VIZIONS): a strategic approach to studying emerging zoonotic infectious diseases. EcoHealth, 12(4), pp. 726-735. (doi: 10.1007/s10393-015-1061-0) (PMID:26403795) (PMCID:PMC4700077)
Watson, S. J. et al. (2015) Molecular epidemiology and evolution of influenza viruses circulating within European swine between 2009 and 2013. Journal of Virology, 89(19), pp. 9920-9931. (doi: 10.1128/JVI.00840-15) (PMID:26202246) (PMCID:PMC4577897)
Jallow, S. et al. (2015) The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. European Journal of Immunology, 45(8), pp. 2232-2242. (doi: 10.1002/eji.201545451) (PMID:26018465) (PMCID:PMC4832300)
Palser, A. L. et al. (2015) Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection. Journal of Virology, 89(10), pp. 5222-5237. (doi: 10.1128/JVI.03614-14) (PMID:25787276) (PMCID:PMC4442510)
Agoti, C. N., Otieno, J. R., Munywoki, P. K., Mwihuri, A. G., Cane, P. A., Nokes, D. J., Kellam, P. and Cotten, M. (2015) Local evolutionary patterns of human respiratory syncytial virus derived from whole-genome sequencing. Journal of Virology, 89(7), pp. 3444-3454. (doi: 10.1128/JVI.03391-14) (PMID:25609811) (PMCID:PMC4403408)
Jazaeri Farsani, S. M. et al. (2015) Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454. Viruses, 7(1), pp. 239-251. (doi: 10.3390/v7010239) (PMID:25606972) (PMCID:PMC4306836)
Hill, S. C. et al. (2015) Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae. Journal of General Virology, 96(6), pp. 1411-1422. (doi: 10.1099/vir.0.000071) (PMID:25626684) (PMCID:PMC4635489)
Oude Munnink, B. B., Cotten, M. , Bakker, M., van der Hoek, L., Jebbink, M. F., Kellam, P., Jazaeri Farsani, S. M., Deijs, M. and Canuti, M. (2015) A novel genus in the order Picornavirales detected in human stool. Journal of General Virology, 96(11), pp. 3440-3443. (doi: 10.1099/jgv.0.000279) (PMID:26354795)
2014
Memish, Z. A. et al. (2014) Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. Journal of Infectious Diseases, 210(10), pp. 1590-1594. (doi: 10.1093/infdis/jiu292) (PMID:24837403)
Cotten, M. , Petrova, V., Phan, M. V. T., Rabaa, M. A., Watson, S. J., Ong, S. H., Kellam, P. and Baker, S. (2014) Deep sequencing of norovirus genomes defines evolutionary patterns in an urban tropical setting. Journal of Virology, 88(19), pp. 11056-11069. (doi: 10.1128/JVI.01333-14) (PMID:25056894) (PMCID:PMC4178781)
Memish, Z. A. et al. (2014) Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerging Infectious Diseases, 20(6), pp. 1012-1015. (doi: 10.3201/eid2006.140402) (PMID:24857749) (PMCID:PMC4036761)
Memish, Z. A., Cotten, M. , Watson, S. J., Kellam, P., Zumla, A., Alhakeem, R. F., Assiri, A., Al Rabeeah, A. A. and Al-Tawfiq, J. A. (2014) Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study. International Journal of Infectious Diseases, 23, pp. 63-68. (doi: 10.1016/j.ijid.2014.03.1372) (PMID:24699184) (PMCID:PMC4441753)
Cotten, M. , Oude Munnink, B., Canuti, M., Deijs, M., Watson, S. J., Kellam, P. and van der Hoek, L. (2014) Full genome virus detection in fecal samples using sensitive nucleic acid preparation, deep sequencing, and a novel iterative sequence classification algorithm. PLoS ONE, 9(4), e93269. (doi: 10.1371/journal.pone.0093269) (PMID:24695106) (PMCID:PMC3973683)
Cotten, M. et al. (2014) Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. mBio, 5(1), e01062-13. (doi: 10.1128/mBio.01062-13) (PMID:24549846) (PMCID:PMC3944817)
Oude Munnink, B. B. et al. (2014) Unexplained diarrhoea in HIV-1 infected individuals. BMC Infectious Diseases, 14, 22. (doi: 10.1186/1471-2334-14-22) (PMID:24410947) (PMCID:PMC3925291)
2013
Cotten, M. et al. (2013) Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study. Lancet, 382(9909), pp. 1993-2002. (doi: 10.1016/S0140-6736(13)61887-5) (PMID:24055451) (PMCID:PMC3898949)
Assiri, A. et al. (2013) Hospital outbreak of Middle East respiratory syndrome coronavirus. New England Journal of Medicine, 369(5), pp. 407-416. (doi: 10.1056/NEJMoa1306742) (PMID:23782161) (PMCID:PMC4029105)
Cotten, M. et al. (2013) Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerging Infectious Diseases, 19(5), pp. 736-742. (doi: 10.3201/eid1905.130057) (PMID:23693015) (PMCID:PMC3647518)
de Silva, T. I. et al. (2013) Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic. AIDS, 27(1), pp. 125-134. (doi: 10.1097/qad.0b013e32835ab12c) (PMID:23032414)
Oude Munnink, B. B. et al. (2013) Autologous antibody capture to enrich immunogenic viruses for viral discovery. PLoS ONE, 8(11), e78454. (doi: 10.1371/journal.pone.0078454) (PMID:24223808) (PMCID:PMC3817278)
2012
Gall, A., Ferns, B., Morris, C., Watson, S., Cotten, M. , Robinson, M., Berry, N., Pillay, D. and Kellam, P. (2012) Universal amplification, next-generation sequencing, and assembly of HIV-1 genomes. Journal of Clinical Microbiology, 50(12), pp. 3838-3844. (doi: 10.1128/jcm.01516-12) (PMID:22993180) (PMCID:PMC3502977)
Kashanchi, F. et al. (2012) Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. PLoS Neglected Tropical Diseases, 6(6), e1690. (doi: 10.1371/journal.pntd.0001690) (PMID:22720106) (PMCID:PMC3373628)
van Tienen, C. et al. (2012) Maternal proviral load and vertical transmission of human T cell lymphotropic virus type 1 in Guinea-Bissau. AIDS Research and Human Retroviruses, 28(6), pp. 584-590. (doi: 10.1089/aid.2011.0219) (PMID:22066980)
de Silva, T. I. et al. (2012) Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes. Journal of Virology, 86(2), pp. 930-946. (doi: 10.1128/jvi.06126-11) (PMID:22072758) (PMCID:PMC3255814)
2011
Stewart, B. et al. (2011) Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa. BMC Research Notes, 4, 561. (doi: 10.1186/1756-0500-4-561) (PMID:22195774) (PMCID:PMC3292846)
van Tienen, C. et al. (2011) HTLV-1 and HIV-2 infection are associated with increased mortality in a rural West African community. PLoS ONE, 6(12), e29026. (doi: 10.1371/journal.pone.0029026) (PMID:22194980) (PMCID:PMC3237577)
Damond, F. et al. (2011) An international collaboration to standardize HIV-2 viral load assays: results from the 2009 ACHIEV2E quality control study. Journal of Clinical Microbiology, 49(10), pp. 3491-3497. (doi: 10.1128/jcm.02389-10) (PMID:21813718) (PMCID:PMC3187346)
van Tienen, C., de Silva, T. I., Alcantara, L. C., Schim van der Loeff, M., Vincent, T., Gonçalves, N., Coutinho, R. A., Aaby, P., Whittle, H. and Cotten, M. (2011) Molecular epidemiology of endemic Human T-Lymphotropic virus 1 (HTLV-1) in a community in rural Guinea-Bissau. Retrovirology, 8(S1), A71. (doi: 10.1186/1742-4690-8-S1-A71) (PMCID:PMC3112787)
van Tienen, C. et al. (2011) Maternal proviral load and vertical transmission of Human T cell Lymphotropic Virus type 1 in Guinea-Bissau. Retrovirology, 8(S1), A72. (doi: 10.1186/1742-4690-8-S1-A72) (PMCID:PMC3112788)
2010
Holder, B. et al. (2010) Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. PLoS ONE, 5(11), e14013. (doi: 10.1371/journal.pone.0014013) (PMID:21103338) (PMCID:PMC2984441)
de Silva, T. I. et al. (2010) HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form. Retrovirology, 7, 82. (doi: 10.1186/1742-4690-7-82) (PMID:20932333) (PMCID:PMC2964586)
Jobarteh, M. et al. (2010) Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. Virology Journal, 7, 230. (doi: 10.1186/1743-422x-7-230) (PMID:20843322) (PMCID:PMC2949835)
Leligdowicz, A., Onyango, C., Yindom, L.-M., Peng, Y., Cotten, M. , Jaye, A., McMichael, A., Whittle, H., Dong, T. and Rowland-Jones, S. (2010) Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. European Journal of Immunology, 40(7), pp. 1963-1972. (doi: 10.1002/eji.200940295) (PMID:20411566)
van Tienen, C. et al. (2010) HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007. Retrovirology, 7, 50. (doi: 10.1186/1742-4690-7-50) (PMID:20525366) (PMCID:PMC2894744)
Onyango, C. O. et al. (2010) HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine, 28(S2), B60-B67. (doi: 10.1016/j.vaccine.2009.08.060) (PMID:20510746)
Leligdowicz, A., Feldmann, J., Jaye, A., Cotten, M. , Dong, T., McMichael, A., Whittle, H. and Rowland-Jones, S. (2010) Direct relationship between virus load and systemic immune activation in HIV-2 infection. Journal of Infectious Diseases, 201(1), pp. 114-122. (doi: 10.1086/648733) (PMID:19938978)
2009
Hontelez, J. A.C., Schimm van der Loeff, M. F., Peterson, I., Peterson, K., Ahadzie, B., Cotten, M. , Sarge-Njie, R. and Whittle, H. F. (2009) Declining trend of serological syphilis among genitourinary medicine patients in the Gambia, West Africa. Sexually transmitted diseases, 36(12), pp. 745-749. (doi: 10.1097/olq.0b013e3181af6de0) (PMID:19704397)
Jallow, S. et al. (2009) Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants. Journal of Clinical Microbiology, 47(7), pp. 2200-2208. (doi: 10.1128/jcm.01654-08) (PMID:19420165) (PMCID:PMC2708512)
Onyango, C. et al. (2009) 139 HIV-2 capsids distinguishing high and low virus load patients in a West African community cohort. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 51, (doi: 10.1097/01.qai.0000351096.55643.09)
2008
de Silva, T. I., Cotten, M. and Rowland-Jones, S. L. (2008) HIV-2: the forgotten AIDS virus. Trends in Microbiology, 16(12), pp. 588-595. (doi: 10.1016/j.tim.2008.09.003) (PMID:18964021)
Ondondo, B. O., Rowland-Jones, S. L., Dorrell, L., Peterson, K., Cotten, M. , Whittle, H. and Jaye, A. (2008) Comprehensive analysis of HIV Gag-specific IFN-gamma response in HIV-1- and HIV-2-infected asymptomatic patients from a clinical cohort in The Gambia. European Journal of Immunology, 38(12), pp. 3549-3560. (doi: 10.1002/eji.200838759) (PMID:19016530)
Mendy, M.E. et al. (2008) Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. Journal of Clinical Microbiology, 46(8), pp. 2723-2730. (doi: 10.1128/jcm.01622-07) (PMID:18508941) (PMCID:PMC2519494)
Damond, F. et al. (2008) Quality control assessment of human immunodeficiency virus type 2 (HIV-2) viral load quantification assays: results from an international collaboration on HIV-2 infection in 2006. Journal of Clinical Microbiology, 46(6), pp. 2088-2091. (doi: 10.1128/jcm.00126-08) (PMID:18434556) (PMCID:PMC2446851)
Jacquet, S., Nishino, Y., Kumphune, S., Sicard, P., Clark, J. E., Kobayashi, K. S., Flavell, R. A., Eickhoff, J., Cotten, M. and Marber, M. S. (2008) The role of RIP2 in p38 MAPK activation in the stressed heart. Journal of Biological Chemistry, 283(18), pp. 11964-11971. (doi: 10.1074/jbc.m707750200) (PMID:18310079) (PMCID:PMC3774113)
2007
Leligdowicz, A. et al. (2007) Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. Journal of Clinical Investigation, 117(10), pp. 3067-3074. (doi: 10.1172/jci32380) (PMID:17823657) (PMCID:PMC1964515)
2005
Godl, K. et al. (2005) Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling. Cancer Research, 65(15), pp. 6919-6926. (doi: 10.1158/0008-5472.can-05-0574) (PMID:16061676)
Eickhoff, J. E. and Cotten, M. (2005) NF-kappaB activation can mediate inhibition of human cytomegalovirus replication. Journal of General Virology, 86(2), pp. 285-295. (doi: 10.1099/vir.0.80458-0) (PMID:15659747)
Brehmer, D. et al. (2005) Cellular targets of gefitinib. Cancer Research, 65(2), pp. 379-382. (PMID:15695376)
2004
Wissing, J. et al. (2004) Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors. Molecular and Cellular Proteomics, 3(12), pp. 1181-1193. (doi: 10.1074/mcp.m400124-mcp200) (PMID:15475568)
Gust, T. C., Diebold, S. S., Cotten, M. and Zenke, M. (2004) RNA-containing adenovirus/polyethylenimine transfer complexes effectively transduce dendritic cells and induce antigen-specific T cell responses. Journal of Gene Medicine, 6(4), pp. 464-470. (doi: 10.1002/jgm.492) (PMID:15079821)
Eickhoff, J. et al. (2004) RICK activates a NF-κB-dependent anti-human cytomegalovirus response. Journal of Biological Chemistry, 279(10), pp. 9642-9652. (doi: 10.1074/jbc.m312893200) (PMID:14670961)
2003
Godl, K. et al. (2003) An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 100(26), pp. 15434-15439. (doi: 10.1073/pnas.2535024100) (PMID:14668439) (PMCID:PMC307585)
Cotten, M. , Stegmueller, K., Eickhoff, J., Hanke, M., Herzberger, K., Herget, T., Choidas, A., Daub, H. and Godl, K. (2003) Exploiting features of adenovirus replication to support mammalian kinase production. Nucleic Acids Research, 31(21), e128. (doi: 10.1093/nar/gng128) (PMID:14576328) (PMCID:PMC275485)
Wick, N., Luedemann, S., Vietor, I., Cotten, M. , Wildpaner, M., Schneider, G., Eisenhaber, F. and Huber, L. A. (2003) Induction of short interspersed nuclear repeat-containing transcripts in epithelial cells upon infection with a chicken adenovirus. Journal of Molecular Biology, 328(4), pp. 779-790. (doi: 10.1016/S0022-2836(03)00363-2) (PMID:12729754)
Zech, B. et al. (2003) Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein. Journal of General Virology, 84(3), pp. 555-560. (doi: 10.1099/vir.0.18801-0) (PMID:12604805)
2002
Diebold, S. S., Plank, C., Cotten, M. , Wagner, E. and Zenke, M. (2002) Mannose receptor-mediated gene delivery into antigen presenting dendritic cells. Somatic Cell and Molecular Genetics, 27(1-6), pp. 65-74. (doi: 10.1023/a:1022975705406) (PMID:12774941)
Vietor, I. et al. (2002) TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO Journal, 21(17), pp. 4621-4631. (doi: 10.1093/emboj/cdf461) (PMID:12198164) (PMCID:PMC125408)
Daub, H., Blencke, S., Habenberger, P., Kurtenback, A., Dennenmoser, J., Wissing, J., Ullrich, A. and Cotten, M. (2002) Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. Journal of Virology, 76(16), pp. 8124-8137. (doi: 10.1128/jvi.76.16.8124-8137.2002) (PMID:12134018) (PMCID:PMC155132)
Chiocca, S., Kurtev, V., Colombo, R., Boggio, R., Sciurpi, M. T., Brosch, G., Seiser, C., Draetta, G. F. and Cotten, M. (2002) Histone deacetylase 1 inactivation by an adenovirus early gene product. Current Biology, 12(7), pp. 594-598. (doi: 10.1016/s0960-9822(02)00720-0) (PMID:11937030)
2001
Tan, P. K., Michou, A.-I., Bergelson, J. M. and Cotten, M. (2001) Defining CAR as a cellular receptor for the avian adenovirus CELO using a genetic analysis of the two viral fibre proteins. Journal of General Virology, 82(6), pp. 1465-1472. (doi: 10.1099/0022-1317-82-6-1465) (PMID:11369892)
Impagnatiello, M.-A., Weitzer, S., Gannon, G., Compagni, A., Cotten, M. and Christofori, G. (2001) Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Journal of Cell Biology, 152(5), pp. 1087-1098. (doi: 10.1083/jcb.152.5.1087) (PMID:11238463)
Diebold, S.S., Cotten, M. , Koch, N. and Zenke, M. (2001) MHC class II presentation of endogenously expressed antigens by transfected dendritic cells. Gene Therapy, 8(6), pp. 487-493. (doi: 10.1038/sj.gt.3301433) (PMID:11313828)
Glotzer, J. B., Michou, A.-I., Baker, A., Saltik, M. and Cotten, M. (2001) Microtubule-independent motility and nuclear targeting of adenoviruses with fluorescently labeled genomes. Journal of Virology, 75(5), pp. 2421-2434. (doi: 10.1128/jvi.75.5.2421-2434.2001) (PMID:11160745) (PMCID:PMC114825)
2000
Compagni, A., Wilgenbus, P., Impagnatiello, M.-A., Cotten, M. and Christofori, G. (2000) Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Research, 60(24), pp. 7163-7169. (PMID:11156426)
Glotzer, J. B., Saltik, M., Chiocca, S., Michou, A.-I., Moseley, P. and Cotten, M. (2000) Activation of heat-shock response by an adenovirus is essential for virus replication. Nature, 407(6801), pp. 207-211. (doi: 10.1038/35025102) (PMID:11001061)
Brunner, S., Sauer, T., Carotta, S., Cotten, M. , Saltik, M. and Wagner, E. (2000) Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Therapy, 7(5), pp. 401-407. (doi: 10.1038/sj.gt.3301102) (PMID:10694822)
1999
Lehrmann, H. and Cotten, M. (1999) Characterization of CELO virus proteins that modulate the pRb/E2F pathway. Journal of Virology, 73(8), pp. 6517-6525. (PMID:10400747) (PMCID:PMC112734)
Diebold, S. S., Kursa, M., Wagner, E., Cotten, M. and Zenke, M. (1999) Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells. Journal of Biological Chemistry, 274(27), pp. 19087-19094. (doi: 10.1074/jbc.274.27.19087) (PMID:10383411)
Diebold, S. S., Lehrmann, H., Kursa, M., Wagner, E., Cotten, M. and Zenke, M. (1999) Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Human Gene Therapy, 10(5), pp. 775-786. (doi: 10.1089/10430349950018535) (PMID:10210145)
Bischof, J., Vietor, I., Cotten, M. and Huber, L.A. (1999) Transient transfection of mammary epithelial cells with a PEI/DNA/adenovirus system. Biological Chemistry, 380(2), pp. 269-273. (doi: 10.1515/bc.1999.036) (PMID:10195435)
Michou, A.-I., Lehrmann, H., Saltik, M. and Cotten, M. (1999) Mutational analysis of the avian adenovirus CELO, which provides a basis for gene delivery vectors. Journal of Virology, 73(2), pp. 1399-1410. (PMID:9882345)
1998
Diebold, S. S., Cotten, M. , Wagner, E. and Zenke, M. (1998) Gene-modified dendritic cells by receptor-mediated transfection. Advances in Experimental Medicine and Biology, 451, pp. 449-455. (doi: 10.1007/978-1-4615-5357-1_69) (PMID:10026910)
Chiocca, S. and Cotten, M. (1998) Characteristics of adenovirus vectors. In: Chiocca, E. A. and Breakefield, X. O. (eds.) Gene Therapy for Neurological Disorders and Brain Tumors. Series: Contemporary neuroscience. Humana Press: Totowa, N.J., pp. 39-52. ISBN 9781475753141 (doi: 10.1007/978-1-59259-478-8_2)
1997
Lamm, G. M., Steinlein, P., Cotten, M. and Christofori, G. (1997) A rapid, quantitative and inexpensive method for detecting apoptosis by flow cytometry in transiently transfected cells. Nucleic Acids Research, 25(23), pp. 4855-4857. (doi: 10.1093/nar/25.23.4855) (PMID:9365268)
Talsma, H., Cherng, J.-Y., Lehrmann, H., Kursa, M., Ogris, M., Hennink, W. E., Cotten, M. and Wagner, E. (1997) Stabilization of gene delivery systems by freeze-drying. International Journal of Pharmaceutics, 157(2), pp. 233-238. (doi: 10.1016/s0378-5173(97)00244-5) (PMID:10477820)
Baker, A., Saltik, M., Lehrmann, H., Killisch, I., Mautner, V., Lamm, G., Christofori, G. and Cotten, M. (1997) Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery. Gene Therapy, 4(8), pp. 773-782. (doi: 10.1038/sj.gt.3300471) (PMID:9338005)
Baker, A. and Cotten, M. (1997) Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier. Nucleic Acids Research, 25(10), pp. 1950-1956. (doi: 10.1093/nar/25.10.1950) (PMID:9115362) (PMCID:PMC146693)
Novoa, I., Benavente, J., Cotten, M. and Carrasco, L. (1997) Permeabilization of mammalian cells to proteins: poliovirus 2A(pro) as a probe to analyze entry of proteins into cells. Experimental Cell Research, 232(1), pp. 186-190. (doi: 10.1006/excr.1997.3533) (PMID:9141636)
Chiocca, S., Baker, A. and Cotten, M. (1997) Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus. Journal of Virology, 71(4), pp. 3168-3177. (PMID:9060680) (PMCID:PMC191449)
Cotten, M. and Saltik, M. (1997) Intracellular delivery of lipopolysaccharide during DNA transfection activates a lipid A-dependent cell death response that can be prevented by polymyxin B. Human Gene Therapy, 8(5), pp. 555-561. (doi: 10.1089/hum.1997.8.5-555) (PMID:9095407)
1996
Cotten, M. , Baker, A., Birnstiel, M. L., Zatloukal, K. and Wagner, E. (1996) Preparation of adenovirus-polylysine-DNA complexes. Current Protocols in Human Genetics, 11(1), 12.3.1-12.3.33. (doi: 10.1002/0471142905.hg1203s11) (PMID:18428249)
Chiocca, S., Kurzbauer, R., Schaffner, G., Baker, A., Mautner, V. and Cotten, M. (1996) The complete DNA sequence and genomic organization of the avian adenovirus CELO. Journal of Virology, 70(5), pp. 2939-2949. (PMID:8627769) (PMCID:PMC190152)
Novoa, I., Cotten, M. and Carrasco, L. (1996) Hybrid proteins between Pseudomonas aeruginosa exotoxin A and poliovirus 2Apro cleave p220 in HeLa cells. Journal of Virology, 70(5), pp. 3319-3324. (PMID:8627818) (PMCID:PMC190201)
1995
Schreiber, M., Baumann, B., Cotten, M. , Angel, P. and Wagner, E.F. (1995) Fos is an essential component of the mammalian UV response. EMBO Journal, 14(21), pp. 5338-5349. (doi: 10.1002/j.1460-2075.1995.tb00218.x) (PMID:7489723) (PMCID:PMC394643)
Cotten, M. and Weber, J. M. (1995) The adenovirus protease is required for virus entry into host cells. Virology, 213(2), pp. 494-502. (doi: 10.1006/viro.1995.0022) (PMID:7491774)
Buschle, M., Cotten, M. , Kirlappos, H., Mechtler, K., Schaffner, G., Zauner, W., Birnstiel, M. L. and Wagner, E. (1995) Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. Human Gene Therapy, 6(6), pp. 753-761. (doi: 10.1089/hum.1995.6.6-753) (PMID:7548275)
Zatloukal, K., Schneeberger, A., Berger, M., Schmidt, W., Koszik, F., Kutil, R., Cotten, M. , Wagner, E., Buschle, M. and Maass, G. (1995) Elicitation of a systemic and protective anti-melanoma immune response by an IL-2-based vaccine. Assessment of critical cellular and molecular parameters. Journal of Immunology, 154(7), pp. 3406-3419. (PMID:7897222)
von Rüden, T., Stingl, T., Cotten, M. , Wagner, E. and Zatloukal, K. (1995) Generation of high-titer retroviral vectors following receptor-mediated, adenovirus-augmented transfection. BioTechniques, 18(3), pp. 484-489. (PMID:7779400)
Cotten, M. (1995) Adenovirus-augmented, receptor-mediated gene delivery and some solutions to the common toxicity problems. In: Doerfler, W. and Böhm, P. (eds.) The Molecular Repertoire of Adenoviruses III. Series: Current topics in microbiology and immunology. Springer, pp. 283-295. ISBN 9783642795886
1994
Cotten, M. , Saltik, M., Kursa, M., Wagner, E., Maass, G. and Birnstiel, M. L. (1994) Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology, 205(1), pp. 254-261. (doi: 10.1006/viro.1994.1641) (PMID:7975222)
Frank, S. et al. (1994) High-level expression of various apolipoprotein(a) isoforms by "transferrinfection": the role of kringle IV sequences in the extracellular association with low-density lipoprotein. Biochemistry, 33(40), pp. 12329-12339. (doi: 10.1021/bi00206a041) (PMID:7918455)
Thurnher, M., Wagner, E., Clausen, E., Mechtler, K., Rusconi, S., Dinter, A., Birnstiel, M. L., Berger, E. G. and Cotten, M. (1994) Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. Glycobiology, 4(4), pp. 429-435. (doi: 10.1093/glycob/4.4.429) (PMID:7827404)
Cotten, M. , Baker, A., Saltik, M., Wagner, E. and Buschle, M. (1994) Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus. Gene Therapy, 1(4), pp. 239-246. (PMID:7584087)
Zatloukal, Z., Cotten, M. , Berger, M., Schmidt, W., Wagner, E. and Birnstiel, M.L. (1994) In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery. Proceedings of the National Academy of Sciences of the United States of America, 91(11), pp. 5148-5152. (doi: 10.1073/pnas.91.11.5148) (PMID:8197198) (PMCID:PMC43949)
Curiel, T. J., Cook, D. R., Bogedain, C., Jilg, W., Harrison, G. S., Cotten, M. , Curiel, D. T. and Wagner, E. (1994) Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells. Virology, 198(2), pp. 577-585. (doi: 10.1006/viro.1994.1069) (PMID:8291240)
Zatloukal, K., Schneeberger, A., Berger, M., Koszik, F., Schmidt, W., Wagner, E., Cotten, M. , Buschle, M., Maass, G. and Stingl, G. (1994) Genetic modification of cells by receptor-mediated adenovirus-augmented gene delivery: a new approach for immunotherapy of cancer. Verhandlungen der Deutschen Gesellschaft fur Pathologie, 78, pp. 171-176. (PMID:7533981)
1993
Zatloukal, K., Schmidt, W., Cotten, M. , Wagner, E., Stingl, G. and Birnstiel, M. L. (1993) Somatic gene therapy for cancer: the utility of transferrinfection in generating 'tumor vaccines'. Gene, 135(1-2), pp. 199-207. (doi: 10.1016/0378-1119(93)90066-c) (PMID:8276260)
Cotten, M. and Wagner, E. (1993) Non-viral approaches to gene therapy. Current Opinion in Biotechnology, 4(6), pp. 705-710. (doi: 10.1016/0958-1669(93)90053-y) (PMID:7764468)
Cotten, M. , Wagner, E., Zatloukal, K. and Birnstiel, M.L. (1993) Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants. Journal of Virology, 67(7), pp. 3777-3785. (PMID:8099627) (PMCID:PMC237742)
Gao, L., Wagner, E., Cotten, M. , Agarwal, S., Harris, C., Rømer, M., Miller, L., Hu, P.-C. and Curiel, D. (1993) Direct in vivo gene transfer to airway epithelium employing adenovirus-polylysine-DNA complexes. Human Gene Therapy, 4(1), pp. 17-24. (doi: 10.1089/hum.1993.4.1-17) (PMID:8461380)
Cotten, M. , Wagner, E. and Birnstiel, M. L. (1993) Receptor-mediated transport of DNA into eukaryotic cells. Methods in Enzymology, 217, pp. 618-644. (doi: 10.1016/0076-6879(93)17092-j) (PMID:8386298)
1992
Plank, C., Zatloukal, K., Cotten, M. , Mechtler, K. and Wagner, E. (1992) Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chemistry, 3(6), pp. 533-539. (doi: 10.1021/bc00018a012) (PMID:1463783)
Zatloukal, K., Wagner, E., Cotten, M. , Phillips, S., Plank, C., Steinlein, P., Curiel, D. T. and Birnstiel, M. L. (1992) Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells. Annals of the New York Academy of Sciences, 660(1), pp. 136-153. (doi: 10.1111/j.1749-6632.1992.tb21066.x) (PMID:1340117)
Wagner, E., Plank, C., Zatloukal, K., Cotten, M. and Birnstiel, M.L. (1992) Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proceedings of the National Academy of Sciences of the United States of America, 89(17), pp. 7934-7938. (doi: 10.1073/pnas.89.17.7934) (PMID:1518816) (PMCID:PMC49829)
Phillips, S., Cotten, M. , Laengle-Rouault, F., Schaffner, G. and Birnstiel, M. L. (1992) Amphibian oocytes and sphere organelles: are the U snRNA genes amplified? Chromosoma, 101(9), pp. 549-556. (doi: 10.1007/bf00660314) (PMID:1521499)
Cotten, M. , Wagner, E., Zatloukal, K., Phillips, S., Curiel, D.T. and Birnstiel, M.L. (1992) High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proceedings of the National Academy of Sciences of the United States of America, 89(13), pp. 6094-6098. (doi: 10.1073/pnas.89.13.6094) (PMID:1352882) (PMCID:PMC49444)
Wagner, E., Zatloukal, Z., Cotten, M. , Kirlappos, H., Mechtler, K., Curiel, D.T. and Birnstiel, M.L. (1992) Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proceedings of the National Academy of Sciences of the United States of America, 89(13), pp. 6099-6103. (doi: 10.1073/pnas.89.13.6099) (PMID:1631096) (PMCID:PMC49445)
Curiel, D. T., Wagner, E., Cotten, M. , Birnstiel, M. L., Agarwal, S., Li, C.-M., Loechel, S. and Hu, P.-C. (1992) High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Human Gene Therapy, 3(2), pp. 147-154. (doi: 10.1089/hum.1992.3.2-147) (PMID:1391034)
Curiel, D. T., Agarwal, S., Rømer, M. U., Wagner, E., Cotten, M. , Birnstiel, M. L. and Boucher, R. C. (1992) Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. American Journal of Respiratory Cell and Molecular Biology, 6(3), pp. 247-252. (doi: 10.1165/ajrcmb/6.3.247) (PMID:1540389)
1991
Wagner, E., Oberhauser, B., Holzner, A., Brunar, H., Issakides, G., Schaffner, G., Cotten, M. , Knollmüller, M. and Noe, C. R. (1991) A simple procedure for the preparation of protected 2'-O-methyl or 2'-O-ethyl ribonucleoside-3'-O-phosphoramidites. Nucleic Acids Research, 19(21), pp. 5965-5971. (doi: 10.1093/nar/19.21.5965) (PMID:1945882) (PMCID:PMC329054)
Curiel, D.T., Agarwal, S., Wagner, E. and Cotten, M. (1991) Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proceedings of the National Academy of Sciences of the United States of America, 88(19), pp. 8850-8854. (doi: 10.1073/pnas.88.19.8850) (PMID:1681545) (PMCID:PMC52608)
Wagner, E., Cotten, M. , Mechtler, K., Kirlappos, H. and Birnstiel, M. L. (1991) DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. Bioconjugate Chemistry, 2(4), pp. 226-231. (doi: 10.1021/bc00010a006) (PMID:1772904)
Cotten, M. , Oberhauser, B., Brunar, H., Holzner, A., Issakides, G., Noe, C. R., Schaffner, G., Wagner, E. and Brinstiel, M. L. (1991) 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. Nucleic Acids Research, 19(10), pp. 2629-2635. (doi: 10.1093/nar/19.10.2629) (PMID:1710340) (PMCID:PMC328180)
Wagner, E., Cotten, M. , Foisner, R. and Birnstiel, M.L. (1991) Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proceedings of the National Academy of Sciences of the United States of America, 88(10), pp. 4255-4259. (doi: 10.1073/pnas.88.10.4255) (PMID:2034670) (PMCID:PMC51637)
1990
Cotten, M. , Längle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H. and Birnstiel, M.L. (1990) Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proceedings of the National Academy of Sciences of the United States of America, 87(11), pp. 4033-4037. (doi: 10.1073/pnas.87.11.4033) (PMID:2349215) (PMCID:PMC54041)
Zenke, M., Steinlein, P., Wagner, E., Cotten, M. , Beug, H. and Birnstiel, M.L. (1990) Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America, 87(10), pp. 3655-3659. (doi: 10.1073/pnas.87.10.3655) (PMID:2339110) (PMCID:PMC53961)
Wagner, E., Zenke, M., Cotten, M. , Beug, H. and Birnstiel, M.L. (1990) Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proceedings of the National Academy of Sciences of the United States of America, 87(9), pp. 3410-3414. (PMID:2333290) (PMCID:PMC53910)
Cotten, M. (1990) The in vivo application of ribozymes. Trends in Biotechnology, 8, pp. 174-178. (doi: 10.1016/0167-7799(90)90168-w) (PMID:1366621)
1989
Cotten, M. and Birnstiel, M.L. (1989) Ribozyme mediated destruction of RNA in vivo. EMBO Journal, 8(12), pp. 3861-3866. (doi: 10.1002/j.1460-2075.1989.tb08564.x) (PMID:2684648) (PMCID:PMC402074)
Cotten, M. , Schaffner, G. and Birnstiel, M.L. (1989) Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro. Molecular and Cellular Biology, 9(10), pp. 4479-4487. (doi: 10.1128/mcb.9.10.4479) (PMID:2479828) (PMCID:PMC362532)
Sealy, L., Burgess, R. R., Cotten, M. and Chalkley, R. (1989) Purification of Xenopus egg nucleoplasmin and its use in chromatin assembly in vitro. Methods in Enzymology, 170, pp. 612-630. (doi: 10.1016/0076-6879(89)70068-9) (PMID:2549340)
1988
Cotten, M. , Gick, O., Vasserot, A., Schaffner, G. and Birnstiel, M.L. (1988) Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction. EMBO Journal, 7(3), pp. 801-808. (doi: 10.1002/j.1460-2075.1988.tb02878.x) (PMID:3396543) (PMCID:PMC454395)
1987
Cotten, M. and Chalkley, R. (1987) Purification of a novel, nucleoplasmin-like protein from somatic nuclei. EMBO Journal, 6(13), pp. 3945-3954. (doi: 10.1002/j.1460-2075.1987.tb02736.x) (PMID:3443097) (PMCID:PMC553873)
1986
Sealy, L., Cotten, M. and Chalkley, R. (1986) Novobiocin inhibits passive chromatin assembly in vitro. EMBO Journal, 5(12), pp. 3305-3311. (doi: 10.1002/j.1460-2075.1986.tb04644.x) (PMID:3028779) (PMCID:PMC1167327)
Cotten, M. , Sealy, L. and Chalkley, R. (1986) Massive phosphorylation distinguishes Xenopus laevis nucleoplasmin isolated from oocytes or unfertilized eggs. Biochemistry, 25(18), pp. 5063-5069. (doi: 10.1021/bi00366a014) (PMID:3768332)
Sealy, L., Cotten, M. and Chalkley, R. (1986) Xenopus nucleoplasmin: egg vs. oocyte. Biochemistry, 25(10), pp. 3064-3072. (doi: 10.1021/bi00358a049) (PMID:3521726)
Cotten, M. , Bresnahan, D., Thompson, S., Sealy, L. and Chalkeley, R. (1986) Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase. Nucleic Acids Research, 14(9), pp. 3671-3686. (doi: 10.1093/nar/14.9.3671) (PMID:3714493) (PMCID:PMC339807)
1985
Cotten, M. and Chalkley, R. (1985) Hyperacetylated histones facilitate chromatin assembly in vitro. Nucleic Acids Research, 13(2), pp. 401-414. (doi: 10.1093/nar/13.2.401) (PMID:2582355) (PMCID:PMC341004)
1983
Horowitz, J., Cotten, M. L. , Hardin, C. C. and Gollnick, P. (1983) Characterization of the fluorodihydrouracil substituent in 5-fluorouracil-containing Escherichia coli transfer RNA. Biochimica et Biophysica Acta: Gene Structure and Expression, 741(1), pp. 70-76. (doi: 10.1016/0167-4781(83)90011-8) (PMID:6351924)
Hills, D. C., Cotten, M. L. and Horowitz, J. (1983) Isolation and characterization of two 5-fluorouracil-substituted Escherichia coli initiator methionine transfer ribonucleic acids. Biochemistry, 22(5), pp. 1113-1122. (doi: 10.1021/bi00274a019) (PMID:6188484)
Articles
Cotten, M. and Phan, M. V.T. (2023) Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission. iScience, 26(3), 106230. (doi: 10.1016/j.isci.2023.106230) (PMID:36845032) (PMCID:PMC9937996)
Tegally, H. et al. (2022) The evolving SARS-CoV-2 epidemic in Africa: insights from rapidly expanding genomic surveillance. Science, 378(6615), eabq5358. (doi: 10.1126/science.abq5358) (PMID:36108049) (PMCID:PMC9529057)
Kwok, K. T. T. , de Rooij, M. M. T., Messink, A. B., Wouters, I. M., Smit, L. A. M., Cotten, M. , Heederik, D. J. J., Koopmans, M. P. G. and Phan, M. V. T. (2022) Establishing farm dust as a useful viral metagenomic surveillance matrix. Scientific Reports, 12, 16308. (doi: 10.1038/s41598-022-20701-x) (PMID:36175536) (PMCID:PMC9521564)
Lubinski, B., Frazier, L. E., Phan, M. V. T., Bugembe, D. L., Cunningham, J. L., Tang, T., Daniel, S., Cotten, M. , Jaimes, J. A. and Whittaker, G. R. (2022) Spike protein cleavage-activation in the context of the SARS-CoV-2 P681R mutation: an analysis from its first appearance in lineage A.23.1 identified in Uganda. Microbiology Spectrum, 10(4), e0151422. (doi: 10.1128/spectrum.01514-22) (PMID:35766497)
Namuwulya, P., Bukenya, H., Tushabe, P., Tweyongyere, R., Bwogi, J., Cotten, M. and Phan, M. V. T. (2022) Near-complete genome sequences of measles virus strains from 10 years of Uganda country-wide surveillance. Microbiology Resource Announcements, 11(8), e0060622. (doi: 10.1128/mra.00606-22) (PMID:35876572) (PMCID:PMC9387275)
Agoti, C. N. et al. (2022) Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: a retrospective genomic study. eLife, 11, e71703. (doi: 10.7554/elife.71703) (PMID:35699426) (PMCID:PMC9282859)
Phan, M. V. T., Agoti, C. N., Munywoki, P. K., Otieno, G. P., Ngama, M., Kellam, P., Cotten, M. and Nokes, D. J. (2022) Identification of missed viruses by metagenomic sequencing of clinical respiratory samples from Kenya. Scientific Reports, 12(1), 202. (doi: 10.1038/s41598-021-03987-1) (PMID:34997042) (PMCID:PMC8742071)
Lutalo, T. et al. (2021) Evaluation of the performance of 25 SARS-CoV-2 serological rapid diagnostic tests using a reference panel of plasma specimens at the Uganda Virus Research Institute. International Journal of Infectious Diseases, 112, pp. 281-287. (doi: 10.1016/j.ijid.2021.09.020) (PMID:34536612) (PMCID:PMC8442260)
Wilkinson, E. et al. (2021) A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa. Science, 374(6566), pp. 423-431. (doi: 10.1126/science.abj4336)
Cotten, M. , Robertson, D. L. and Phan, M. V.T. (2021) Unique protein features of SARS-CoV-2 relative to other Sarbecoviruses. Virus Evolution, 7(2), veab067. (doi: 10.1093/ve/veab067) (PMID:34527286) (PMCID:PMC8385934)
Bugembe, D. L. et al. (2021) Emergence and spread of a SARS-CoV-2 lineage A variant (A.23.1) with altered spike protein in Uganda. Nature Microbiology, 6(8), pp. 1094-1101. (doi: 10.1038/s41564-021-00933-9) (PMID:34163035) (PMCID:PMC8318884)
Roach, M. et al. (2021) No evidence known viruses play a role in the pathogenesis of onchocerciasis-associated epilepsy. An explorative metagenomic case-control study. Pathogens, 10(7), 787. (doi: 10.3390/pathogens10070787) (PMID:34206564) (PMCID:PMC8308762)
Lambisia, A. W., Phan, M. V. T., de Laurent, Z. R., Cotten, M. , Nokes, D. J., Agoti, C. N. and Matthijnssens, J. (2021) Near-complete genome sequences of eight human astroviruses recovered from diarrheal stool samples of hospitalized children in coastal Kenya in 2019. Microbiology Resource Announcements, 10(15), e00162-21. (doi: 10.1128/MRA.00162-21) (PMID:33858926) (PMCID:PMC8050968)
Allesøe, R. L., Lemvigh, C. K., Phan, M. V.T., Clausen, P. T. L.C., Florensa, A. F., Koopmans, M. P.G., Lund, O. and Cotten, M. (2021) Automated download and clean-up of family-specific databases for kmer-based virus identification. Bioinformatics, 37(5), pp. 705-710. (doi: 10.1093/bioinformatics/btaa857) (PMID:33031509) (PMCID:PMC8097684)
Nalumansi, A. et al. (2021) Field evaluation of the performance of a SARS-CoV-2 antigen rapid diagnostic test in Uganda using nasopharyngeal samples. International Journal of Infectious Diseases, 104, pp. 282-286. (doi: 10.1016/j.ijid.2020.10.073) (PMID:33130198) (PMCID:PMC7836828)
Kapaata, A. et al. (2021) HIV-1 Gag-Pol sequences from Ugandan early infections reveal sequence variants associated with elevated replication capacity. Viruses, 13(2), 171. (doi: 10.3390/v13020171) (PMID:33498793) (PMCID:PMC7912664)
Cotten, M. , Bugembe, D. L., Kaleebu, P. and Phan, M. V.T. (2021) Alternate primers for whole-genome SARS-CoV-2 sequencing. Virus Evolution, 7(1), veab006. (doi: 10.1093/ve/veab006) (PMID:33841912) (PMCID:PMC7928614)
Bugembe, D. L. et al. (2020) Main routes of entry and genomic diversity of SARS-CoV-2, Uganda. Emerging Infectious Diseases, 26(10), pp. 2411-2415. (doi: 10.3201/eid2610.202575) (PMID:32614767) (PMCID:PMC7510740)
Kinsella, C. M., Bart, A., Deijs, M., Broekhuizen, P., Kaczorowska, J., Jebbink, M. F., van Gool, T., Cotten, M. and van der Hoek, L. (2020) Entamoeba and Giardia parasites implicated as hosts of CRESS viruses. Nature Communications, 11, 4620. (doi: 10.1038/s41467-020-18474-w) (PMID:32934242) (PMCID:PMC7493932)
Barry, M. et al. (2020) Nosocomial outbreak of the Middle East Respiratory Syndrome coronavirus: a phylogenetic, epidemiological, clinical and infection control analysis. Travel Medicine and Infectious Disease, 37, 101807. (doi: 10.1016/j.tmaid.2020.101807) (PMID:32599173) (PMCID:PMC7319941)
Nieuwenhuijse, D. F. et al. (2020) Setting a baseline for global urban virome surveillance in sewage. Scientific Reports, 10, 13748. (doi: 10.1038/s41598-020-69869-0) (PMID:32792677) (PMCID:PMC7426863)
Masembe, C. , Phan, M. V.T., Robertson, D. L. and Cotten, M. (2020) Increased resolution of African swine fever virus genome patterns based on profile HMMs of protein domains. Virus Evolution, 6(2), veaa044. (doi: 10.1093/ve/veaa044) (PMID:32913663) (PMCID:PMC7474929)
Phan, M. V.T., Mendonca Melo, M., van Nood, E., Aron, G., Kreeft-Voermans, J. J.C., Koopmans, M. P.G., Reusken, C., GeurtsvanKessel, C. H. and Cotten, M. (2020) Shedding of yellow fever virus from an imported case in the Netherlands after travel to Brazil. Open Forum Infectious Diseases, 7(2), ofaa020. (doi: 10.1093/ofid/ofaa020) (PMID:32055637) (PMCID:PMC7008093)
Amid, C. et al. (2019) The COMPARE Data Hubs. Database, 2019, baz136. (doi: 10.1093/database/baz136) (PMID:31868882) (PMCID:PMC6927095)
Strubbia, S., Phan, M. V.T., Schaeffer, J., Koopmans, M., Cotten, M. and Le Guyader, F. S. (2019) Characterization of Norovirus and other human enteric viruses in sewage and stool samples through next-generation sequencing. Food and Environmental Virology, 11(4), pp. 400-409. (doi: 10.1007/s12560-019-09402-3) (PMID:31446609) (PMCID:PMC6848244)
Agoti, C. N., Phan, M. V.T., Munywoki, P. K., Githinji, G., Medley, G. F., Cane, P. A., Kellam, P., Cotten, M. and Nokes, D. J. (2019) Genomic analysis of respiratory syncytial virus infections in households and utility in inferring who infects the infant. Scientific Reports, 9(1), 10076. (doi: 10.1038/s41598-019-46509-w) (PMID:31296922) (PMCID:PMC6624209)
Tapinos, A., Constantinides, B., Phan, M. V. T., Kouchaki, S., Cotten, M. and Robertson, D. L. (2019) The utility of data transformation for alignment, de novo assembly and classification of short read virus sequences. Viruses, 11(5), 394. (doi: 10.3390/v11050394) (PMID:31035503) (PMCID:PMC6563281)
Canuti, M., Williams, C. V., Sagan, S. M., Oude Munnink, B. B., Gadi, S., Verhoeven, J. T. P., Kellam, P. and Cotten, M. (2019) Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs. Archives of Virology, 164(2), pp. 509-522. (doi: 10.1007/s00705-018-4099-9) (PMID:30460488)
Phan, M. V.T., Arron, G., Geurts van Kessel, C. H., Hulsman, R. C., Molenkamp, R., Koopmans, M. P.G. and Cotten, M. (2019) Complete genome characterization of eight human parainfluenza viruses from the Netherlands. Microbiology Resource Announcements, 8(15), e00125-19. (doi: 10.1128/MRA.00125-19) (PMID:30975805) (PMCID:PMC6460028)
Said Mohammed, K., Kibinge, N., Prins, P., Agoti, C. N., Cotten, M. , Nokes, D.J., Brand, S. and Githinji, G. (2018) Evaluating the performance of tools used to call minority variants from whole genome short-read data. Wellcome Open Research, 3, 21. (doi: 10.12688/wellcomeopenres.13538.2) (PMID:30483597) (PMCID:PMC6234735)
Otieno, J.R. et al. (2018) Whole genome analysis of local Kenyan and global sequences unravels the epidemiological and molecular evolutionary dynamics of RSV genotype ON1 strains. Virus Evolution, 4(2), vey027. (doi: 10.1093/ve/vey027) (PMID:30271623) (PMCID:PMC6153471)
Phan, M. V.T., Tri, T. N., Anh, P. H., Baker, S., VIZIONS Consortium, , Kellam, P. and Cotten, M. (2018) Identification and characterization of Coronaviridae genomes from Vietnamese bats and rats based on conserved protein domains. Virus Evolution, 4(2), vey035. (doi: 10.1093/ve/vey035) (PMID:30568804) (PMCID:PMC6295324)
Kiyuka, P. K. et al. (2018) Human coronavirus NL63 molecular epidemiology and evolutionary patterns in rural coastal Kenya. Journal of Infectious Diseases, 217(11), pp. 1728-1739. (doi: 10.1093/infdis/jiy098) (PMID:29741740) (PMCID:PMC6037089)
My, V. V.T., Schapendonk, C. M.E., Oude Munnink, B. B., Koopmans, M. P.G., de Swart, R. L. and Cotten, M. (2018) Complete genome sequences of six measles virus strains. Genome Announcements, 6(13), e00184-18. (doi: 10.1128/genomea.00184-18) (PMID:29599155) (PMCID:PMC5876482)
de Silva, T. I. et al. (2018) HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 32(6), pp. 709-714. (doi: 10.1097/QAD.0000000000001753) (PMID:29369160) (PMCID:PMC5895130)
Berto, A. et al. (2018) Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam. Zoonoses and Public Health, 65(1), pp. 30-42. (doi: 10.1111/zph.12362) (PMID:28418192) (PMCID:PMC5811810)
Berto, A. et al. (2018) Hepatitis E in southern Vietnam: seroepidemiology in humans and molecular epidemiology in pigs. Zoonoses and Public Health, 65(1), pp. 43-50. (doi: 10.1111/zph.12364) (PMID:28598034) (PMCID:PMC6645987)
Oude Munnink, B. B., Phan, M. V.T., The VIZIONS Consortium, , Simmonds, P., Koopmans, M. P.G., Kellam, P., van der Hoek, L. and Cotten, M. (2017) Characterization of Posa and Posa-like virus genomes in fecal samples from humans, pigs, rats, and bats collected from a single location in Vietnam. Virus Evolution, 3(2), vex002. (doi: 10.1093/ve/vex022) (PMID:28948041) (PMCID:PMC5597861)
Dudas, G. et al. (2017) Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature, 544(7650), pp. 309-315. (doi: 10.1038/nature22040) (PMID:28405027) (PMCID:PMC5712493)
Dolle, D. D., Liu, Z., Cotten, M. , Simpson, J. T., Iqbal, Z., Durbin, R., McCarthy, S. A. and Jeabe, T. M. (2017) Using reference-free compressed data structures to analyze sequencing reads from thousands of human genomes. Genome Research, 27(2), pp. 300-309. (doi: 10.1101/gr.211748.116) (PMID:27986821) (PMCID:PMC5287235)
Agoti, C. N. et al. (2017) Transmission patterns and evolution of respiratory syncytial virus in a community outbreak identified by genomic analysis. Virus Evolution, 3(1), vex006. (doi: 10.1093/ve/vex006) (PMID:28458916) (PMCID:PMC5399923)
Fraaij, P.L.A. et al. (2016) Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016. European Communicable Disease Bulletin, 21(48), pii: 30416. (doi: 10.2807/1560-7917.es.2016.21.48.30416) (PMID:27934581) (PMCID:PMC5388114)
Cotten, M. and Koopmans, M. (2016) Next-generation sequencing and norovirus. Future Virology, 11(11), pp. 719-722. (doi: 10.2217/fvl-2016-0099) (PMID:28757893)
Diallo, B. et al. (2016) Resurgence of ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days. Clinical Infectious Diseases, 63(10), pp. 1353-1356. (doi: 10.1093/cid/ciw601) (PMID:27585800) (PMCID:PMC5091350)
Zumla, A., Alagaili, A. N., Cotten, M. and Azhar, E. I. (2016) Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East Respiratory syndrome coronavirus (MERS-CoV). BMC Medicine, 14, 132. (doi: 10.1186/s12916-016-0686-3) (PMID:27604081) (PMCID:PMC5015245)
Agoti, C. N., Kiyuka, P. K., Kamau, E., Munywoki, P. K., Bett, A., van der Hoek, L., Kellam, P., Nokes, D. J. and Cotten, M. (2016) Human rhinovirus B and C genomes from rural coastal Kenya. Genome Announcements, 4(4), e00751-16. (doi: 10.1128/genomeA.00751-16) (PMID:27469941) (PMCID:PMC4966474)
Phan, M. V. T. et al. (2016) Unbiased whole-genome deep sequencing of human and porcine stool samples reveals circulation of multiple groups of rotaviruses and a putative zoonotic infection. Virus Evolution, 2(2), vew027. (doi: 10.1093/ve/vew027) (PMID:28748110) (PMCID:PMC5522372)
Zumla, A. et al. (2016) Taking forward a 'One Health' approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential. International Journal of Infectious Diseases, 47, pp. 5-9. (doi: 10.1016/j.ijid.2016.06.012) (PMID:27321961)
Zumla, A., Goodfellow, I., Kasolo, F., Ntoumi, F., Buchy, P., Bates, M., Azhar, E. I., Cotten, M. and Petersen, E. (2016) Zika virus outbreak and the case for building effective and sustainable rapid diagnostics laboratory capacity globally. International Journal of Infectious Diseases, 45, pp. 92-94. (doi: 10.1016/j.ijid.2016.02.1007) (PMID:26952389)
Arias, A. et al. (2016) Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases. Virus Evolution, 2(1), vew016. (doi: 10.1093/ve/vew016) (PMID:28694998) (PMCID:PMC5499387)
Oude Munnink, B. B. et al. (2016) A novel astrovirus-like RNA virus detected in human stool. Virus Evolution, 2(1), vew005. (doi: 10.1093/ve/vew005) (PMID:27774298) (PMCID:PMC4989881)
Oude Munnink, B. B., Phan, M. V.T., Kellam, P., Cotten, M. and VIZIONS Consortium, (2016) Complete genome characterization of two wild-type measles viruses from Vietnamese infants during the 2014 outbreak. Genome Announcements, 4(2), e00250-16. (doi: 10.1128/genomea.00250-16) (PMID:27081130) (PMCID:PMC4832158)
Oude Munnink, B. B., Phan, M. V.T., van der Hoek, L., Kellam, P., Cotten, M. and VIZIONS Consortium, (2016) Genome sequences of a novel Vietnamese bat bunyavirus. Genome Announcements, 4(6), e01366-16. (doi: 10.1128/genomea.01366-16) (PMID:28007850) (PMCID:PMC5180378)
Rabaa, M. A. et al. (2015) The Vietnam Initiative on Zoonotic Infections (VIZIONS): a strategic approach to studying emerging zoonotic infectious diseases. EcoHealth, 12(4), pp. 726-735. (doi: 10.1007/s10393-015-1061-0) (PMID:26403795) (PMCID:PMC4700077)
Watson, S. J. et al. (2015) Molecular epidemiology and evolution of influenza viruses circulating within European swine between 2009 and 2013. Journal of Virology, 89(19), pp. 9920-9931. (doi: 10.1128/JVI.00840-15) (PMID:26202246) (PMCID:PMC4577897)
Jallow, S. et al. (2015) The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. European Journal of Immunology, 45(8), pp. 2232-2242. (doi: 10.1002/eji.201545451) (PMID:26018465) (PMCID:PMC4832300)
Palser, A. L. et al. (2015) Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection. Journal of Virology, 89(10), pp. 5222-5237. (doi: 10.1128/JVI.03614-14) (PMID:25787276) (PMCID:PMC4442510)
Agoti, C. N., Otieno, J. R., Munywoki, P. K., Mwihuri, A. G., Cane, P. A., Nokes, D. J., Kellam, P. and Cotten, M. (2015) Local evolutionary patterns of human respiratory syncytial virus derived from whole-genome sequencing. Journal of Virology, 89(7), pp. 3444-3454. (doi: 10.1128/JVI.03391-14) (PMID:25609811) (PMCID:PMC4403408)
Jazaeri Farsani, S. M. et al. (2015) Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454. Viruses, 7(1), pp. 239-251. (doi: 10.3390/v7010239) (PMID:25606972) (PMCID:PMC4306836)
Hill, S. C. et al. (2015) Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae. Journal of General Virology, 96(6), pp. 1411-1422. (doi: 10.1099/vir.0.000071) (PMID:25626684) (PMCID:PMC4635489)
Oude Munnink, B. B., Cotten, M. , Bakker, M., van der Hoek, L., Jebbink, M. F., Kellam, P., Jazaeri Farsani, S. M., Deijs, M. and Canuti, M. (2015) A novel genus in the order Picornavirales detected in human stool. Journal of General Virology, 96(11), pp. 3440-3443. (doi: 10.1099/jgv.0.000279) (PMID:26354795)
Memish, Z. A. et al. (2014) Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. Journal of Infectious Diseases, 210(10), pp. 1590-1594. (doi: 10.1093/infdis/jiu292) (PMID:24837403)
Cotten, M. , Petrova, V., Phan, M. V. T., Rabaa, M. A., Watson, S. J., Ong, S. H., Kellam, P. and Baker, S. (2014) Deep sequencing of norovirus genomes defines evolutionary patterns in an urban tropical setting. Journal of Virology, 88(19), pp. 11056-11069. (doi: 10.1128/JVI.01333-14) (PMID:25056894) (PMCID:PMC4178781)
Memish, Z. A. et al. (2014) Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerging Infectious Diseases, 20(6), pp. 1012-1015. (doi: 10.3201/eid2006.140402) (PMID:24857749) (PMCID:PMC4036761)
Memish, Z. A., Cotten, M. , Watson, S. J., Kellam, P., Zumla, A., Alhakeem, R. F., Assiri, A., Al Rabeeah, A. A. and Al-Tawfiq, J. A. (2014) Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study. International Journal of Infectious Diseases, 23, pp. 63-68. (doi: 10.1016/j.ijid.2014.03.1372) (PMID:24699184) (PMCID:PMC4441753)
Cotten, M. , Oude Munnink, B., Canuti, M., Deijs, M., Watson, S. J., Kellam, P. and van der Hoek, L. (2014) Full genome virus detection in fecal samples using sensitive nucleic acid preparation, deep sequencing, and a novel iterative sequence classification algorithm. PLoS ONE, 9(4), e93269. (doi: 10.1371/journal.pone.0093269) (PMID:24695106) (PMCID:PMC3973683)
Cotten, M. et al. (2014) Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. mBio, 5(1), e01062-13. (doi: 10.1128/mBio.01062-13) (PMID:24549846) (PMCID:PMC3944817)
Oude Munnink, B. B. et al. (2014) Unexplained diarrhoea in HIV-1 infected individuals. BMC Infectious Diseases, 14, 22. (doi: 10.1186/1471-2334-14-22) (PMID:24410947) (PMCID:PMC3925291)
Cotten, M. et al. (2013) Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study. Lancet, 382(9909), pp. 1993-2002. (doi: 10.1016/S0140-6736(13)61887-5) (PMID:24055451) (PMCID:PMC3898949)
Assiri, A. et al. (2013) Hospital outbreak of Middle East respiratory syndrome coronavirus. New England Journal of Medicine, 369(5), pp. 407-416. (doi: 10.1056/NEJMoa1306742) (PMID:23782161) (PMCID:PMC4029105)
Cotten, M. et al. (2013) Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerging Infectious Diseases, 19(5), pp. 736-742. (doi: 10.3201/eid1905.130057) (PMID:23693015) (PMCID:PMC3647518)
de Silva, T. I. et al. (2013) Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic. AIDS, 27(1), pp. 125-134. (doi: 10.1097/qad.0b013e32835ab12c) (PMID:23032414)
Oude Munnink, B. B. et al. (2013) Autologous antibody capture to enrich immunogenic viruses for viral discovery. PLoS ONE, 8(11), e78454. (doi: 10.1371/journal.pone.0078454) (PMID:24223808) (PMCID:PMC3817278)
Gall, A., Ferns, B., Morris, C., Watson, S., Cotten, M. , Robinson, M., Berry, N., Pillay, D. and Kellam, P. (2012) Universal amplification, next-generation sequencing, and assembly of HIV-1 genomes. Journal of Clinical Microbiology, 50(12), pp. 3838-3844. (doi: 10.1128/jcm.01516-12) (PMID:22993180) (PMCID:PMC3502977)
Kashanchi, F. et al. (2012) Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. PLoS Neglected Tropical Diseases, 6(6), e1690. (doi: 10.1371/journal.pntd.0001690) (PMID:22720106) (PMCID:PMC3373628)
van Tienen, C. et al. (2012) Maternal proviral load and vertical transmission of human T cell lymphotropic virus type 1 in Guinea-Bissau. AIDS Research and Human Retroviruses, 28(6), pp. 584-590. (doi: 10.1089/aid.2011.0219) (PMID:22066980)
de Silva, T. I. et al. (2012) Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes. Journal of Virology, 86(2), pp. 930-946. (doi: 10.1128/jvi.06126-11) (PMID:22072758) (PMCID:PMC3255814)
Stewart, B. et al. (2011) Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa. BMC Research Notes, 4, 561. (doi: 10.1186/1756-0500-4-561) (PMID:22195774) (PMCID:PMC3292846)
van Tienen, C. et al. (2011) HTLV-1 and HIV-2 infection are associated with increased mortality in a rural West African community. PLoS ONE, 6(12), e29026. (doi: 10.1371/journal.pone.0029026) (PMID:22194980) (PMCID:PMC3237577)
Damond, F. et al. (2011) An international collaboration to standardize HIV-2 viral load assays: results from the 2009 ACHIEV2E quality control study. Journal of Clinical Microbiology, 49(10), pp. 3491-3497. (doi: 10.1128/jcm.02389-10) (PMID:21813718) (PMCID:PMC3187346)
van Tienen, C., de Silva, T. I., Alcantara, L. C., Schim van der Loeff, M., Vincent, T., Gonçalves, N., Coutinho, R. A., Aaby, P., Whittle, H. and Cotten, M. (2011) Molecular epidemiology of endemic Human T-Lymphotropic virus 1 (HTLV-1) in a community in rural Guinea-Bissau. Retrovirology, 8(S1), A71. (doi: 10.1186/1742-4690-8-S1-A71) (PMCID:PMC3112787)
van Tienen, C. et al. (2011) Maternal proviral load and vertical transmission of Human T cell Lymphotropic Virus type 1 in Guinea-Bissau. Retrovirology, 8(S1), A72. (doi: 10.1186/1742-4690-8-S1-A72) (PMCID:PMC3112788)
Holder, B. et al. (2010) Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. PLoS ONE, 5(11), e14013. (doi: 10.1371/journal.pone.0014013) (PMID:21103338) (PMCID:PMC2984441)
de Silva, T. I. et al. (2010) HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form. Retrovirology, 7, 82. (doi: 10.1186/1742-4690-7-82) (PMID:20932333) (PMCID:PMC2964586)
Jobarteh, M. et al. (2010) Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. Virology Journal, 7, 230. (doi: 10.1186/1743-422x-7-230) (PMID:20843322) (PMCID:PMC2949835)
Leligdowicz, A., Onyango, C., Yindom, L.-M., Peng, Y., Cotten, M. , Jaye, A., McMichael, A., Whittle, H., Dong, T. and Rowland-Jones, S. (2010) Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. European Journal of Immunology, 40(7), pp. 1963-1972. (doi: 10.1002/eji.200940295) (PMID:20411566)
van Tienen, C. et al. (2010) HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007. Retrovirology, 7, 50. (doi: 10.1186/1742-4690-7-50) (PMID:20525366) (PMCID:PMC2894744)
Onyango, C. O. et al. (2010) HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine, 28(S2), B60-B67. (doi: 10.1016/j.vaccine.2009.08.060) (PMID:20510746)
Leligdowicz, A., Feldmann, J., Jaye, A., Cotten, M. , Dong, T., McMichael, A., Whittle, H. and Rowland-Jones, S. (2010) Direct relationship between virus load and systemic immune activation in HIV-2 infection. Journal of Infectious Diseases, 201(1), pp. 114-122. (doi: 10.1086/648733) (PMID:19938978)
Hontelez, J. A.C., Schimm van der Loeff, M. F., Peterson, I., Peterson, K., Ahadzie, B., Cotten, M. , Sarge-Njie, R. and Whittle, H. F. (2009) Declining trend of serological syphilis among genitourinary medicine patients in the Gambia, West Africa. Sexually transmitted diseases, 36(12), pp. 745-749. (doi: 10.1097/olq.0b013e3181af6de0) (PMID:19704397)
Jallow, S. et al. (2009) Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants. Journal of Clinical Microbiology, 47(7), pp. 2200-2208. (doi: 10.1128/jcm.01654-08) (PMID:19420165) (PMCID:PMC2708512)
Onyango, C. et al. (2009) 139 HIV-2 capsids distinguishing high and low virus load patients in a West African community cohort. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 51, (doi: 10.1097/01.qai.0000351096.55643.09)
de Silva, T. I., Cotten, M. and Rowland-Jones, S. L. (2008) HIV-2: the forgotten AIDS virus. Trends in Microbiology, 16(12), pp. 588-595. (doi: 10.1016/j.tim.2008.09.003) (PMID:18964021)
Ondondo, B. O., Rowland-Jones, S. L., Dorrell, L., Peterson, K., Cotten, M. , Whittle, H. and Jaye, A. (2008) Comprehensive analysis of HIV Gag-specific IFN-gamma response in HIV-1- and HIV-2-infected asymptomatic patients from a clinical cohort in The Gambia. European Journal of Immunology, 38(12), pp. 3549-3560. (doi: 10.1002/eji.200838759) (PMID:19016530)
Mendy, M.E. et al. (2008) Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. Journal of Clinical Microbiology, 46(8), pp. 2723-2730. (doi: 10.1128/jcm.01622-07) (PMID:18508941) (PMCID:PMC2519494)
Damond, F. et al. (2008) Quality control assessment of human immunodeficiency virus type 2 (HIV-2) viral load quantification assays: results from an international collaboration on HIV-2 infection in 2006. Journal of Clinical Microbiology, 46(6), pp. 2088-2091. (doi: 10.1128/jcm.00126-08) (PMID:18434556) (PMCID:PMC2446851)
Jacquet, S., Nishino, Y., Kumphune, S., Sicard, P., Clark, J. E., Kobayashi, K. S., Flavell, R. A., Eickhoff, J., Cotten, M. and Marber, M. S. (2008) The role of RIP2 in p38 MAPK activation in the stressed heart. Journal of Biological Chemistry, 283(18), pp. 11964-11971. (doi: 10.1074/jbc.m707750200) (PMID:18310079) (PMCID:PMC3774113)
Leligdowicz, A. et al. (2007) Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. Journal of Clinical Investigation, 117(10), pp. 3067-3074. (doi: 10.1172/jci32380) (PMID:17823657) (PMCID:PMC1964515)
Godl, K. et al. (2005) Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling. Cancer Research, 65(15), pp. 6919-6926. (doi: 10.1158/0008-5472.can-05-0574) (PMID:16061676)
Eickhoff, J. E. and Cotten, M. (2005) NF-kappaB activation can mediate inhibition of human cytomegalovirus replication. Journal of General Virology, 86(2), pp. 285-295. (doi: 10.1099/vir.0.80458-0) (PMID:15659747)
Brehmer, D. et al. (2005) Cellular targets of gefitinib. Cancer Research, 65(2), pp. 379-382. (PMID:15695376)
Wissing, J. et al. (2004) Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors. Molecular and Cellular Proteomics, 3(12), pp. 1181-1193. (doi: 10.1074/mcp.m400124-mcp200) (PMID:15475568)
Gust, T. C., Diebold, S. S., Cotten, M. and Zenke, M. (2004) RNA-containing adenovirus/polyethylenimine transfer complexes effectively transduce dendritic cells and induce antigen-specific T cell responses. Journal of Gene Medicine, 6(4), pp. 464-470. (doi: 10.1002/jgm.492) (PMID:15079821)
Eickhoff, J. et al. (2004) RICK activates a NF-κB-dependent anti-human cytomegalovirus response. Journal of Biological Chemistry, 279(10), pp. 9642-9652. (doi: 10.1074/jbc.m312893200) (PMID:14670961)
Godl, K. et al. (2003) An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 100(26), pp. 15434-15439. (doi: 10.1073/pnas.2535024100) (PMID:14668439) (PMCID:PMC307585)
Cotten, M. , Stegmueller, K., Eickhoff, J., Hanke, M., Herzberger, K., Herget, T., Choidas, A., Daub, H. and Godl, K. (2003) Exploiting features of adenovirus replication to support mammalian kinase production. Nucleic Acids Research, 31(21), e128. (doi: 10.1093/nar/gng128) (PMID:14576328) (PMCID:PMC275485)
Wick, N., Luedemann, S., Vietor, I., Cotten, M. , Wildpaner, M., Schneider, G., Eisenhaber, F. and Huber, L. A. (2003) Induction of short interspersed nuclear repeat-containing transcripts in epithelial cells upon infection with a chicken adenovirus. Journal of Molecular Biology, 328(4), pp. 779-790. (doi: 10.1016/S0022-2836(03)00363-2) (PMID:12729754)
Zech, B. et al. (2003) Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein. Journal of General Virology, 84(3), pp. 555-560. (doi: 10.1099/vir.0.18801-0) (PMID:12604805)
Diebold, S. S., Plank, C., Cotten, M. , Wagner, E. and Zenke, M. (2002) Mannose receptor-mediated gene delivery into antigen presenting dendritic cells. Somatic Cell and Molecular Genetics, 27(1-6), pp. 65-74. (doi: 10.1023/a:1022975705406) (PMID:12774941)
Vietor, I. et al. (2002) TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO Journal, 21(17), pp. 4621-4631. (doi: 10.1093/emboj/cdf461) (PMID:12198164) (PMCID:PMC125408)
Daub, H., Blencke, S., Habenberger, P., Kurtenback, A., Dennenmoser, J., Wissing, J., Ullrich, A. and Cotten, M. (2002) Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. Journal of Virology, 76(16), pp. 8124-8137. (doi: 10.1128/jvi.76.16.8124-8137.2002) (PMID:12134018) (PMCID:PMC155132)
Chiocca, S., Kurtev, V., Colombo, R., Boggio, R., Sciurpi, M. T., Brosch, G., Seiser, C., Draetta, G. F. and Cotten, M. (2002) Histone deacetylase 1 inactivation by an adenovirus early gene product. Current Biology, 12(7), pp. 594-598. (doi: 10.1016/s0960-9822(02)00720-0) (PMID:11937030)
Tan, P. K., Michou, A.-I., Bergelson, J. M. and Cotten, M. (2001) Defining CAR as a cellular receptor for the avian adenovirus CELO using a genetic analysis of the two viral fibre proteins. Journal of General Virology, 82(6), pp. 1465-1472. (doi: 10.1099/0022-1317-82-6-1465) (PMID:11369892)
Impagnatiello, M.-A., Weitzer, S., Gannon, G., Compagni, A., Cotten, M. and Christofori, G. (2001) Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Journal of Cell Biology, 152(5), pp. 1087-1098. (doi: 10.1083/jcb.152.5.1087) (PMID:11238463)
Diebold, S.S., Cotten, M. , Koch, N. and Zenke, M. (2001) MHC class II presentation of endogenously expressed antigens by transfected dendritic cells. Gene Therapy, 8(6), pp. 487-493. (doi: 10.1038/sj.gt.3301433) (PMID:11313828)
Glotzer, J. B., Michou, A.-I., Baker, A., Saltik, M. and Cotten, M. (2001) Microtubule-independent motility and nuclear targeting of adenoviruses with fluorescently labeled genomes. Journal of Virology, 75(5), pp. 2421-2434. (doi: 10.1128/jvi.75.5.2421-2434.2001) (PMID:11160745) (PMCID:PMC114825)
Compagni, A., Wilgenbus, P., Impagnatiello, M.-A., Cotten, M. and Christofori, G. (2000) Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Research, 60(24), pp. 7163-7169. (PMID:11156426)
Glotzer, J. B., Saltik, M., Chiocca, S., Michou, A.-I., Moseley, P. and Cotten, M. (2000) Activation of heat-shock response by an adenovirus is essential for virus replication. Nature, 407(6801), pp. 207-211. (doi: 10.1038/35025102) (PMID:11001061)
Brunner, S., Sauer, T., Carotta, S., Cotten, M. , Saltik, M. and Wagner, E. (2000) Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Therapy, 7(5), pp. 401-407. (doi: 10.1038/sj.gt.3301102) (PMID:10694822)
Lehrmann, H. and Cotten, M. (1999) Characterization of CELO virus proteins that modulate the pRb/E2F pathway. Journal of Virology, 73(8), pp. 6517-6525. (PMID:10400747) (PMCID:PMC112734)
Diebold, S. S., Kursa, M., Wagner, E., Cotten, M. and Zenke, M. (1999) Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells. Journal of Biological Chemistry, 274(27), pp. 19087-19094. (doi: 10.1074/jbc.274.27.19087) (PMID:10383411)
Diebold, S. S., Lehrmann, H., Kursa, M., Wagner, E., Cotten, M. and Zenke, M. (1999) Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Human Gene Therapy, 10(5), pp. 775-786. (doi: 10.1089/10430349950018535) (PMID:10210145)
Bischof, J., Vietor, I., Cotten, M. and Huber, L.A. (1999) Transient transfection of mammary epithelial cells with a PEI/DNA/adenovirus system. Biological Chemistry, 380(2), pp. 269-273. (doi: 10.1515/bc.1999.036) (PMID:10195435)
Michou, A.-I., Lehrmann, H., Saltik, M. and Cotten, M. (1999) Mutational analysis of the avian adenovirus CELO, which provides a basis for gene delivery vectors. Journal of Virology, 73(2), pp. 1399-1410. (PMID:9882345)
Diebold, S. S., Cotten, M. , Wagner, E. and Zenke, M. (1998) Gene-modified dendritic cells by receptor-mediated transfection. Advances in Experimental Medicine and Biology, 451, pp. 449-455. (doi: 10.1007/978-1-4615-5357-1_69) (PMID:10026910)
Lamm, G. M., Steinlein, P., Cotten, M. and Christofori, G. (1997) A rapid, quantitative and inexpensive method for detecting apoptosis by flow cytometry in transiently transfected cells. Nucleic Acids Research, 25(23), pp. 4855-4857. (doi: 10.1093/nar/25.23.4855) (PMID:9365268)
Talsma, H., Cherng, J.-Y., Lehrmann, H., Kursa, M., Ogris, M., Hennink, W. E., Cotten, M. and Wagner, E. (1997) Stabilization of gene delivery systems by freeze-drying. International Journal of Pharmaceutics, 157(2), pp. 233-238. (doi: 10.1016/s0378-5173(97)00244-5) (PMID:10477820)
Baker, A., Saltik, M., Lehrmann, H., Killisch, I., Mautner, V., Lamm, G., Christofori, G. and Cotten, M. (1997) Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery. Gene Therapy, 4(8), pp. 773-782. (doi: 10.1038/sj.gt.3300471) (PMID:9338005)
Baker, A. and Cotten, M. (1997) Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier. Nucleic Acids Research, 25(10), pp. 1950-1956. (doi: 10.1093/nar/25.10.1950) (PMID:9115362) (PMCID:PMC146693)
Novoa, I., Benavente, J., Cotten, M. and Carrasco, L. (1997) Permeabilization of mammalian cells to proteins: poliovirus 2A(pro) as a probe to analyze entry of proteins into cells. Experimental Cell Research, 232(1), pp. 186-190. (doi: 10.1006/excr.1997.3533) (PMID:9141636)
Chiocca, S., Baker, A. and Cotten, M. (1997) Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus. Journal of Virology, 71(4), pp. 3168-3177. (PMID:9060680) (PMCID:PMC191449)
Cotten, M. and Saltik, M. (1997) Intracellular delivery of lipopolysaccharide during DNA transfection activates a lipid A-dependent cell death response that can be prevented by polymyxin B. Human Gene Therapy, 8(5), pp. 555-561. (doi: 10.1089/hum.1997.8.5-555) (PMID:9095407)
Cotten, M. , Baker, A., Birnstiel, M. L., Zatloukal, K. and Wagner, E. (1996) Preparation of adenovirus-polylysine-DNA complexes. Current Protocols in Human Genetics, 11(1), 12.3.1-12.3.33. (doi: 10.1002/0471142905.hg1203s11) (PMID:18428249)
Chiocca, S., Kurzbauer, R., Schaffner, G., Baker, A., Mautner, V. and Cotten, M. (1996) The complete DNA sequence and genomic organization of the avian adenovirus CELO. Journal of Virology, 70(5), pp. 2939-2949. (PMID:8627769) (PMCID:PMC190152)
Novoa, I., Cotten, M. and Carrasco, L. (1996) Hybrid proteins between Pseudomonas aeruginosa exotoxin A and poliovirus 2Apro cleave p220 in HeLa cells. Journal of Virology, 70(5), pp. 3319-3324. (PMID:8627818) (PMCID:PMC190201)
Schreiber, M., Baumann, B., Cotten, M. , Angel, P. and Wagner, E.F. (1995) Fos is an essential component of the mammalian UV response. EMBO Journal, 14(21), pp. 5338-5349. (doi: 10.1002/j.1460-2075.1995.tb00218.x) (PMID:7489723) (PMCID:PMC394643)
Cotten, M. and Weber, J. M. (1995) The adenovirus protease is required for virus entry into host cells. Virology, 213(2), pp. 494-502. (doi: 10.1006/viro.1995.0022) (PMID:7491774)
Buschle, M., Cotten, M. , Kirlappos, H., Mechtler, K., Schaffner, G., Zauner, W., Birnstiel, M. L. and Wagner, E. (1995) Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. Human Gene Therapy, 6(6), pp. 753-761. (doi: 10.1089/hum.1995.6.6-753) (PMID:7548275)
Zatloukal, K., Schneeberger, A., Berger, M., Schmidt, W., Koszik, F., Kutil, R., Cotten, M. , Wagner, E., Buschle, M. and Maass, G. (1995) Elicitation of a systemic and protective anti-melanoma immune response by an IL-2-based vaccine. Assessment of critical cellular and molecular parameters. Journal of Immunology, 154(7), pp. 3406-3419. (PMID:7897222)
von Rüden, T., Stingl, T., Cotten, M. , Wagner, E. and Zatloukal, K. (1995) Generation of high-titer retroviral vectors following receptor-mediated, adenovirus-augmented transfection. BioTechniques, 18(3), pp. 484-489. (PMID:7779400)
Cotten, M. , Saltik, M., Kursa, M., Wagner, E., Maass, G. and Birnstiel, M. L. (1994) Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology, 205(1), pp. 254-261. (doi: 10.1006/viro.1994.1641) (PMID:7975222)
Frank, S. et al. (1994) High-level expression of various apolipoprotein(a) isoforms by "transferrinfection": the role of kringle IV sequences in the extracellular association with low-density lipoprotein. Biochemistry, 33(40), pp. 12329-12339. (doi: 10.1021/bi00206a041) (PMID:7918455)
Thurnher, M., Wagner, E., Clausen, E., Mechtler, K., Rusconi, S., Dinter, A., Birnstiel, M. L., Berger, E. G. and Cotten, M. (1994) Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. Glycobiology, 4(4), pp. 429-435. (doi: 10.1093/glycob/4.4.429) (PMID:7827404)
Cotten, M. , Baker, A., Saltik, M., Wagner, E. and Buschle, M. (1994) Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus. Gene Therapy, 1(4), pp. 239-246. (PMID:7584087)
Zatloukal, Z., Cotten, M. , Berger, M., Schmidt, W., Wagner, E. and Birnstiel, M.L. (1994) In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery. Proceedings of the National Academy of Sciences of the United States of America, 91(11), pp. 5148-5152. (doi: 10.1073/pnas.91.11.5148) (PMID:8197198) (PMCID:PMC43949)
Curiel, T. J., Cook, D. R., Bogedain, C., Jilg, W., Harrison, G. S., Cotten, M. , Curiel, D. T. and Wagner, E. (1994) Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells. Virology, 198(2), pp. 577-585. (doi: 10.1006/viro.1994.1069) (PMID:8291240)
Zatloukal, K., Schneeberger, A., Berger, M., Koszik, F., Schmidt, W., Wagner, E., Cotten, M. , Buschle, M., Maass, G. and Stingl, G. (1994) Genetic modification of cells by receptor-mediated adenovirus-augmented gene delivery: a new approach for immunotherapy of cancer. Verhandlungen der Deutschen Gesellschaft fur Pathologie, 78, pp. 171-176. (PMID:7533981)
Zatloukal, K., Schmidt, W., Cotten, M. , Wagner, E., Stingl, G. and Birnstiel, M. L. (1993) Somatic gene therapy for cancer: the utility of transferrinfection in generating 'tumor vaccines'. Gene, 135(1-2), pp. 199-207. (doi: 10.1016/0378-1119(93)90066-c) (PMID:8276260)
Cotten, M. and Wagner, E. (1993) Non-viral approaches to gene therapy. Current Opinion in Biotechnology, 4(6), pp. 705-710. (doi: 10.1016/0958-1669(93)90053-y) (PMID:7764468)
Cotten, M. , Wagner, E., Zatloukal, K. and Birnstiel, M.L. (1993) Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants. Journal of Virology, 67(7), pp. 3777-3785. (PMID:8099627) (PMCID:PMC237742)
Gao, L., Wagner, E., Cotten, M. , Agarwal, S., Harris, C., Rømer, M., Miller, L., Hu, P.-C. and Curiel, D. (1993) Direct in vivo gene transfer to airway epithelium employing adenovirus-polylysine-DNA complexes. Human Gene Therapy, 4(1), pp. 17-24. (doi: 10.1089/hum.1993.4.1-17) (PMID:8461380)
Cotten, M. , Wagner, E. and Birnstiel, M. L. (1993) Receptor-mediated transport of DNA into eukaryotic cells. Methods in Enzymology, 217, pp. 618-644. (doi: 10.1016/0076-6879(93)17092-j) (PMID:8386298)
Plank, C., Zatloukal, K., Cotten, M. , Mechtler, K. and Wagner, E. (1992) Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chemistry, 3(6), pp. 533-539. (doi: 10.1021/bc00018a012) (PMID:1463783)
Zatloukal, K., Wagner, E., Cotten, M. , Phillips, S., Plank, C., Steinlein, P., Curiel, D. T. and Birnstiel, M. L. (1992) Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells. Annals of the New York Academy of Sciences, 660(1), pp. 136-153. (doi: 10.1111/j.1749-6632.1992.tb21066.x) (PMID:1340117)
Wagner, E., Plank, C., Zatloukal, K., Cotten, M. and Birnstiel, M.L. (1992) Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proceedings of the National Academy of Sciences of the United States of America, 89(17), pp. 7934-7938. (doi: 10.1073/pnas.89.17.7934) (PMID:1518816) (PMCID:PMC49829)
Phillips, S., Cotten, M. , Laengle-Rouault, F., Schaffner, G. and Birnstiel, M. L. (1992) Amphibian oocytes and sphere organelles: are the U snRNA genes amplified? Chromosoma, 101(9), pp. 549-556. (doi: 10.1007/bf00660314) (PMID:1521499)
Cotten, M. , Wagner, E., Zatloukal, K., Phillips, S., Curiel, D.T. and Birnstiel, M.L. (1992) High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proceedings of the National Academy of Sciences of the United States of America, 89(13), pp. 6094-6098. (doi: 10.1073/pnas.89.13.6094) (PMID:1352882) (PMCID:PMC49444)
Wagner, E., Zatloukal, Z., Cotten, M. , Kirlappos, H., Mechtler, K., Curiel, D.T. and Birnstiel, M.L. (1992) Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proceedings of the National Academy of Sciences of the United States of America, 89(13), pp. 6099-6103. (doi: 10.1073/pnas.89.13.6099) (PMID:1631096) (PMCID:PMC49445)
Curiel, D. T., Wagner, E., Cotten, M. , Birnstiel, M. L., Agarwal, S., Li, C.-M., Loechel, S. and Hu, P.-C. (1992) High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Human Gene Therapy, 3(2), pp. 147-154. (doi: 10.1089/hum.1992.3.2-147) (PMID:1391034)
Curiel, D. T., Agarwal, S., Rømer, M. U., Wagner, E., Cotten, M. , Birnstiel, M. L. and Boucher, R. C. (1992) Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. American Journal of Respiratory Cell and Molecular Biology, 6(3), pp. 247-252. (doi: 10.1165/ajrcmb/6.3.247) (PMID:1540389)
Wagner, E., Oberhauser, B., Holzner, A., Brunar, H., Issakides, G., Schaffner, G., Cotten, M. , Knollmüller, M. and Noe, C. R. (1991) A simple procedure for the preparation of protected 2'-O-methyl or 2'-O-ethyl ribonucleoside-3'-O-phosphoramidites. Nucleic Acids Research, 19(21), pp. 5965-5971. (doi: 10.1093/nar/19.21.5965) (PMID:1945882) (PMCID:PMC329054)
Curiel, D.T., Agarwal, S., Wagner, E. and Cotten, M. (1991) Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proceedings of the National Academy of Sciences of the United States of America, 88(19), pp. 8850-8854. (doi: 10.1073/pnas.88.19.8850) (PMID:1681545) (PMCID:PMC52608)
Wagner, E., Cotten, M. , Mechtler, K., Kirlappos, H. and Birnstiel, M. L. (1991) DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. Bioconjugate Chemistry, 2(4), pp. 226-231. (doi: 10.1021/bc00010a006) (PMID:1772904)
Cotten, M. , Oberhauser, B., Brunar, H., Holzner, A., Issakides, G., Noe, C. R., Schaffner, G., Wagner, E. and Brinstiel, M. L. (1991) 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. Nucleic Acids Research, 19(10), pp. 2629-2635. (doi: 10.1093/nar/19.10.2629) (PMID:1710340) (PMCID:PMC328180)
Wagner, E., Cotten, M. , Foisner, R. and Birnstiel, M.L. (1991) Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proceedings of the National Academy of Sciences of the United States of America, 88(10), pp. 4255-4259. (doi: 10.1073/pnas.88.10.4255) (PMID:2034670) (PMCID:PMC51637)
Cotten, M. , Längle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H. and Birnstiel, M.L. (1990) Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proceedings of the National Academy of Sciences of the United States of America, 87(11), pp. 4033-4037. (doi: 10.1073/pnas.87.11.4033) (PMID:2349215) (PMCID:PMC54041)
Zenke, M., Steinlein, P., Wagner, E., Cotten, M. , Beug, H. and Birnstiel, M.L. (1990) Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America, 87(10), pp. 3655-3659. (doi: 10.1073/pnas.87.10.3655) (PMID:2339110) (PMCID:PMC53961)
Wagner, E., Zenke, M., Cotten, M. , Beug, H. and Birnstiel, M.L. (1990) Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proceedings of the National Academy of Sciences of the United States of America, 87(9), pp. 3410-3414. (PMID:2333290) (PMCID:PMC53910)
Cotten, M. (1990) The in vivo application of ribozymes. Trends in Biotechnology, 8, pp. 174-178. (doi: 10.1016/0167-7799(90)90168-w) (PMID:1366621)
Cotten, M. and Birnstiel, M.L. (1989) Ribozyme mediated destruction of RNA in vivo. EMBO Journal, 8(12), pp. 3861-3866. (doi: 10.1002/j.1460-2075.1989.tb08564.x) (PMID:2684648) (PMCID:PMC402074)
Cotten, M. , Schaffner, G. and Birnstiel, M.L. (1989) Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro. Molecular and Cellular Biology, 9(10), pp. 4479-4487. (doi: 10.1128/mcb.9.10.4479) (PMID:2479828) (PMCID:PMC362532)
Sealy, L., Burgess, R. R., Cotten, M. and Chalkley, R. (1989) Purification of Xenopus egg nucleoplasmin and its use in chromatin assembly in vitro. Methods in Enzymology, 170, pp. 612-630. (doi: 10.1016/0076-6879(89)70068-9) (PMID:2549340)
Cotten, M. , Gick, O., Vasserot, A., Schaffner, G. and Birnstiel, M.L. (1988) Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction. EMBO Journal, 7(3), pp. 801-808. (doi: 10.1002/j.1460-2075.1988.tb02878.x) (PMID:3396543) (PMCID:PMC454395)
Cotten, M. and Chalkley, R. (1987) Purification of a novel, nucleoplasmin-like protein from somatic nuclei. EMBO Journal, 6(13), pp. 3945-3954. (doi: 10.1002/j.1460-2075.1987.tb02736.x) (PMID:3443097) (PMCID:PMC553873)
Sealy, L., Cotten, M. and Chalkley, R. (1986) Novobiocin inhibits passive chromatin assembly in vitro. EMBO Journal, 5(12), pp. 3305-3311. (doi: 10.1002/j.1460-2075.1986.tb04644.x) (PMID:3028779) (PMCID:PMC1167327)
Cotten, M. , Sealy, L. and Chalkley, R. (1986) Massive phosphorylation distinguishes Xenopus laevis nucleoplasmin isolated from oocytes or unfertilized eggs. Biochemistry, 25(18), pp. 5063-5069. (doi: 10.1021/bi00366a014) (PMID:3768332)
Sealy, L., Cotten, M. and Chalkley, R. (1986) Xenopus nucleoplasmin: egg vs. oocyte. Biochemistry, 25(10), pp. 3064-3072. (doi: 10.1021/bi00358a049) (PMID:3521726)
Cotten, M. , Bresnahan, D., Thompson, S., Sealy, L. and Chalkeley, R. (1986) Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase. Nucleic Acids Research, 14(9), pp. 3671-3686. (doi: 10.1093/nar/14.9.3671) (PMID:3714493) (PMCID:PMC339807)
Cotten, M. and Chalkley, R. (1985) Hyperacetylated histones facilitate chromatin assembly in vitro. Nucleic Acids Research, 13(2), pp. 401-414. (doi: 10.1093/nar/13.2.401) (PMID:2582355) (PMCID:PMC341004)
Horowitz, J., Cotten, M. L. , Hardin, C. C. and Gollnick, P. (1983) Characterization of the fluorodihydrouracil substituent in 5-fluorouracil-containing Escherichia coli transfer RNA. Biochimica et Biophysica Acta: Gene Structure and Expression, 741(1), pp. 70-76. (doi: 10.1016/0167-4781(83)90011-8) (PMID:6351924)
Hills, D. C., Cotten, M. L. and Horowitz, J. (1983) Isolation and characterization of two 5-fluorouracil-substituted Escherichia coli initiator methionine transfer ribonucleic acids. Biochemistry, 22(5), pp. 1113-1122. (doi: 10.1021/bi00274a019) (PMID:6188484)
Book Sections
Chiocca, S. and Cotten, M. (1998) Characteristics of adenovirus vectors. In: Chiocca, E. A. and Breakefield, X. O. (eds.) Gene Therapy for Neurological Disorders and Brain Tumors. Series: Contemporary neuroscience. Humana Press: Totowa, N.J., pp. 39-52. ISBN 9781475753141 (doi: 10.1007/978-1-59259-478-8_2)
Cotten, M. (1995) Adenovirus-augmented, receptor-mediated gene delivery and some solutions to the common toxicity problems. In: Doerfler, W. and Böhm, P. (eds.) The Molecular Repertoire of Adenoviruses III. Series: Current topics in microbiology and immunology. Springer, pp. 283-295. ISBN 9783642795886