Professor John Kusel
- Honorary Senior Research Fellow (School of Infection & Immunity)
Publications
2019
Kusel, J.R., Vieira, L., Harnett, W., Ruppel, A., Cioli, D., Doenhoff, M., Colley, D., Coelho, P.M.Z., Wilson, R.A. and Cox, E.G. (2019) Personal Experiences During Discoveries in Schistosomiasis. Peertechz Publications. ISBN 9788194305736 (doi: 10.17352/ebook10114)
2017
Jeremias, W. d. J. et al. (2017) Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum. PLoS ONE, 12(6), e0178829. (doi: 10.1371/journal.pone.0178829) (PMID:28622369) (PMCID:PMC5473564)
2013
Vimieiro, A. C. S., Araújo, N., Katz, N., Kusel, J. R. and Coelho, P. M. Z. (2013) Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, 108(7), pp. 881-886. (doi: 10.1590/0074-0276130135) (PMID:24271044) (PMCID:PMC3970651)
2011
Mattos, A. C. A. d., Martins-Souza, R. L., Kusel, J. R. and Coelho, P. M. Z. (2011) Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite. Memorias Do Instituto Oswaldo Cruz, 106(4), pp. 424-432. (doi: 10.1590/s0074-02762011000400007) (PMID:21739029)
Couto, F. F.B., Coelho, P. M. Z., Araújo, N., Kusel, J. R., Katz, N., Jannotti-Passos, L. K. and Mattos, A. C. A. (2011) Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails. Memorias Do Instituto Oswaldo Cruz, 106(2), pp. 153-157. (doi: 10.1590/s0074-02762011000200006) (PMID:21537673)
2010
Thornhill, J., Kusel, J., Alvisi de Oliviera, F., Ribeiro, F., Lima, S. F., Coelho, P. M. Z., McVeigh, P. and Mattos, A. C. A. (2010) Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni). Memorias Do Instituto Oswaldo Cruz, 105(4), pp. 387-390. (doi: 10.1590/s0074-02762010000400007) (PMID:20721480)
Thornhill, J.A., McVeigh, P., Jurberg, A.D. and Kusel, J.R. (2010) Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration. Parasitology, pp. 1-10. (doi: 10.1017/S0031182009991983)
2009
Thornhill, J., Coelho, P.M.Z., McVeigh, P., Maule, A., Jurberg, A.D. and Kusel, J.R. (2009) Schistosoma mansoni cercariae experience influx of macromolecules during skin penetration. Parasitology, 136(11), pp. 1257-1267. (doi: 10.1017/S0031182009990692)
Kusel, J.R., McVeigh, P. and Thornhill, J.A. (2009) The schistosome excretory system: a key to regulation of metabolism, drug excretion and host interaction. Trends in Parasitology, 25(8), pp. 353-358. (doi: 10.1016/j.pt.2009.05.003)
2007
Bahia, D. et al. (2007) Schistosonia mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration. Experimental Parasitology, 116(3), pp. 225-232. (doi: 10.1016/j.exppara.2007.01.009)
Kusel, J., Al-Adhami, B. and Doenhoff, M. (2007) The schistosome in the mammalian host: understanding the mechanisms of adaptation. Parasitology, 134, pp. 1477-1526. (doi: 10.1017/S0031182007002971)
Mattos, A., Pereira, G., Jannotti-Passos, L., Kusel, J. and Coelho, P. (2007) Evaluation of the effect of oxamniquine, praziquantel and a combination of both drugs on the intramolluscan phase of Schistosoma mansoni. Acta Tropica, 102, pp. 84-91. (doi: 10.1016/j.actatropica.2007.04.002)
2006
Kusel, J., Oliveira, F., Todd, M., Ronketti, F., Lima, S., Mattos, A., Reis, K., Coelho, P., Thornhill, J. and Ribeiro, F. (2006) The effects of drugs, ions, and poly-l-lysine on the excretory system of Schistosoma mansoni. Memorias Do Instituto Oswaldo Cruz, 101, pp. 293-298. (doi: 10.1590/s0074-02762006000900046) (PMID:17308785)
Mattos, A., Kusel, J., Pimenta, P. and Coelho, P. (2006) Activity of praziquantel on in vitro transformed Schistosoma mansoni sporocysts. Memorias Do Instituto Oswaldo Cruz, 101(Suppl1), pp. 283-287. (doi: 10.1590/s0074-02762006000900044) (PMID:17308783)
Sarvel, A., Kusel, J., Araujo, N., Coelho, P. and Katz, N. (2006) Comparison between morphological and staining characteristics of live and dead eggs of Schistosoma mansoni. Memorias Do Instituto Oswaldo Cruz, 101(Suppl1), pp. 289-292. (doi: 10.1590/s0074-02762006000900045) (PMID:17308784)
Al-Adhami, B., Nichols, R., Kusel, J., OGrady, J. and Smith, H. (2006) Cryptosporidium parvum sporozoites contain glutathione. Parasitology, 133, pp. 555-563. (doi: 10.1017/S0031182006000497)
Oliveira, F., Kusel, J., Ribeiro, F. and Coelho, P. (2006) Responses of the surface membrane and excretory system of Schistosoma mansoni to damage and to treatment with praziquantel and other biomolecules. Parasitology, 132, pp. 321-330. (doi: 10.1017/S0031182005009169)
2005
Al-Adhami, B., Noble, C., Sharaf, O., Thornhill, J., Doenhoff, M. and Kusel, J. (2005) The role of acidic organelles in the development of schistosomula of Schistosoma mansoni and their response to signalling molecules. Parasitology, 130, pp. 309-322. (doi: 10.1017/D0031182004006511)
Wang, L., Li, Y., Fishelson, Z., Kusel, J. and Ruppel, A. (2005) Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S-mansoni. Parasitology Research, 95, pp. 218-223. (doi: 10.1007/s00436-004-1284-4)
2004
Ribeiro, F., Mello, R. T. d., Tavares, C. A. P., Kusel, J. R. and Coelho, P. M. Z. (2004) Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection. Revista do Instituto de Medicina Tropical de São Paulo, 46(4), pp. 231-233. (doi: 10.1590/s0036-46652004000400010) (PMID:15361976)
Hagan, P., Appleton, C., Coles, G., Kusel, J. and Tchuem-Tchuente, L. (2004) Schistosomiasis control: keep taking the tablets. Trends in Parasitology, 20, pp. 92-97. (doi: 10.1016/j.pt.2003.11.010)
Sato, H., Kusel, J. and Thornhill, J. (2004) Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system. Parasitology, 128, pp. 43-52. (doi: 10.1017/S0031182003004177)
2003
Al-Adhami, B., Thornhill, J., Akhkha, A., Doenhoff, M. and Kusel, J. (2003) The properties of acidic compartments in developing schistosomula of Schistosoma mansoni. Parasitology, 127, pp. 253-264. (doi: 10.1017/S003118200300369X)
Tan, H., Thornhill, J., Al-Adhami, B., Akhkha, A. and Kusel, J. (2003) A study of the effect of surface damage on the uptake of Texas Red-BSA by schistosomula of Schistosoma mansoni. Parasitology, 126, pp. 235-240. (doi: 10.1017/S0031182002002846)
Wippersteg, V., Ribeiro, F., Liedtke, S., Kusel, J. and Grevelding, C. (2003) The uptake of Texas Red-BSA in the excretory system of schistosomes and its colocalisation with ER60 promoter-induced GFP in transiently transformed adult males. International Journal for Parasitology, 33, pp. 1139-1143. (doi: 10.1016/S0020-7519(03)00168-1)
2002
Doenhoff, M., Kusel, J., Coles, G. and Cioli, D. (2002) Resistance of Schistosoma mansoni to praziquantel: is there a problem? Transactions of the Royal Society of Tropical Medicine and Hygiene, 96, pp. 465-469.
Sato, H., Kusel, J. and Thornhill, J. (2002) Functional visualization of the excretory system of adult Schistosoma mansoni by the fluorescent marker resorufin. Parasitology, 125, pp. 527-535. (doi: 10.1017/S0031182002002536)
2001
Al-Adhami, B.H., Doenhoff, M., Thornhill, J., Akhkha, A., White, E. and Kusel, J.R. (2001) A study of some characteristics of individual clones of Schistosoma mansoni with emphasis on the biological and metabolic activities. Parasitology, 123(6), pp. 563-572. (doi: 10.1017/S0031182001008812)
Carneiro-Santos, P., Thornhill, J., Doenhoff, M., Hagan, P. and Kusel, J. (2001) Acidic vesicles of Schistosoma mansoni. Parasitology Research, 87, pp. 1001-1006.
Kusel, J. (2001) Climbing the tree of evolution. Trends in Parasitology, 17(8), pp. 398-399. (doi: 10.1016/S1471-4922(01)01956-0)
Articles
Jeremias, W. d. J. et al. (2017) Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum. PLoS ONE, 12(6), e0178829. (doi: 10.1371/journal.pone.0178829) (PMID:28622369) (PMCID:PMC5473564)
Vimieiro, A. C. S., Araújo, N., Katz, N., Kusel, J. R. and Coelho, P. M. Z. (2013) Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, 108(7), pp. 881-886. (doi: 10.1590/0074-0276130135) (PMID:24271044) (PMCID:PMC3970651)
Mattos, A. C. A. d., Martins-Souza, R. L., Kusel, J. R. and Coelho, P. M. Z. (2011) Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite. Memorias Do Instituto Oswaldo Cruz, 106(4), pp. 424-432. (doi: 10.1590/s0074-02762011000400007) (PMID:21739029)
Couto, F. F.B., Coelho, P. M. Z., Araújo, N., Kusel, J. R., Katz, N., Jannotti-Passos, L. K. and Mattos, A. C. A. (2011) Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails. Memorias Do Instituto Oswaldo Cruz, 106(2), pp. 153-157. (doi: 10.1590/s0074-02762011000200006) (PMID:21537673)
Thornhill, J., Kusel, J., Alvisi de Oliviera, F., Ribeiro, F., Lima, S. F., Coelho, P. M. Z., McVeigh, P. and Mattos, A. C. A. (2010) Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni). Memorias Do Instituto Oswaldo Cruz, 105(4), pp. 387-390. (doi: 10.1590/s0074-02762010000400007) (PMID:20721480)
Thornhill, J.A., McVeigh, P., Jurberg, A.D. and Kusel, J.R. (2010) Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration. Parasitology, pp. 1-10. (doi: 10.1017/S0031182009991983)
Thornhill, J., Coelho, P.M.Z., McVeigh, P., Maule, A., Jurberg, A.D. and Kusel, J.R. (2009) Schistosoma mansoni cercariae experience influx of macromolecules during skin penetration. Parasitology, 136(11), pp. 1257-1267. (doi: 10.1017/S0031182009990692)
Kusel, J.R., McVeigh, P. and Thornhill, J.A. (2009) The schistosome excretory system: a key to regulation of metabolism, drug excretion and host interaction. Trends in Parasitology, 25(8), pp. 353-358. (doi: 10.1016/j.pt.2009.05.003)
Bahia, D. et al. (2007) Schistosonia mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration. Experimental Parasitology, 116(3), pp. 225-232. (doi: 10.1016/j.exppara.2007.01.009)
Kusel, J., Al-Adhami, B. and Doenhoff, M. (2007) The schistosome in the mammalian host: understanding the mechanisms of adaptation. Parasitology, 134, pp. 1477-1526. (doi: 10.1017/S0031182007002971)
Mattos, A., Pereira, G., Jannotti-Passos, L., Kusel, J. and Coelho, P. (2007) Evaluation of the effect of oxamniquine, praziquantel and a combination of both drugs on the intramolluscan phase of Schistosoma mansoni. Acta Tropica, 102, pp. 84-91. (doi: 10.1016/j.actatropica.2007.04.002)
Kusel, J., Oliveira, F., Todd, M., Ronketti, F., Lima, S., Mattos, A., Reis, K., Coelho, P., Thornhill, J. and Ribeiro, F. (2006) The effects of drugs, ions, and poly-l-lysine on the excretory system of Schistosoma mansoni. Memorias Do Instituto Oswaldo Cruz, 101, pp. 293-298. (doi: 10.1590/s0074-02762006000900046) (PMID:17308785)
Mattos, A., Kusel, J., Pimenta, P. and Coelho, P. (2006) Activity of praziquantel on in vitro transformed Schistosoma mansoni sporocysts. Memorias Do Instituto Oswaldo Cruz, 101(Suppl1), pp. 283-287. (doi: 10.1590/s0074-02762006000900044) (PMID:17308783)
Sarvel, A., Kusel, J., Araujo, N., Coelho, P. and Katz, N. (2006) Comparison between morphological and staining characteristics of live and dead eggs of Schistosoma mansoni. Memorias Do Instituto Oswaldo Cruz, 101(Suppl1), pp. 289-292. (doi: 10.1590/s0074-02762006000900045) (PMID:17308784)
Al-Adhami, B., Nichols, R., Kusel, J., OGrady, J. and Smith, H. (2006) Cryptosporidium parvum sporozoites contain glutathione. Parasitology, 133, pp. 555-563. (doi: 10.1017/S0031182006000497)
Oliveira, F., Kusel, J., Ribeiro, F. and Coelho, P. (2006) Responses of the surface membrane and excretory system of Schistosoma mansoni to damage and to treatment with praziquantel and other biomolecules. Parasitology, 132, pp. 321-330. (doi: 10.1017/S0031182005009169)
Al-Adhami, B., Noble, C., Sharaf, O., Thornhill, J., Doenhoff, M. and Kusel, J. (2005) The role of acidic organelles in the development of schistosomula of Schistosoma mansoni and their response to signalling molecules. Parasitology, 130, pp. 309-322. (doi: 10.1017/D0031182004006511)
Wang, L., Li, Y., Fishelson, Z., Kusel, J. and Ruppel, A. (2005) Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S-mansoni. Parasitology Research, 95, pp. 218-223. (doi: 10.1007/s00436-004-1284-4)
Ribeiro, F., Mello, R. T. d., Tavares, C. A. P., Kusel, J. R. and Coelho, P. M. Z. (2004) Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection. Revista do Instituto de Medicina Tropical de São Paulo, 46(4), pp. 231-233. (doi: 10.1590/s0036-46652004000400010) (PMID:15361976)
Hagan, P., Appleton, C., Coles, G., Kusel, J. and Tchuem-Tchuente, L. (2004) Schistosomiasis control: keep taking the tablets. Trends in Parasitology, 20, pp. 92-97. (doi: 10.1016/j.pt.2003.11.010)
Sato, H., Kusel, J. and Thornhill, J. (2004) Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system. Parasitology, 128, pp. 43-52. (doi: 10.1017/S0031182003004177)
Al-Adhami, B., Thornhill, J., Akhkha, A., Doenhoff, M. and Kusel, J. (2003) The properties of acidic compartments in developing schistosomula of Schistosoma mansoni. Parasitology, 127, pp. 253-264. (doi: 10.1017/S003118200300369X)
Tan, H., Thornhill, J., Al-Adhami, B., Akhkha, A. and Kusel, J. (2003) A study of the effect of surface damage on the uptake of Texas Red-BSA by schistosomula of Schistosoma mansoni. Parasitology, 126, pp. 235-240. (doi: 10.1017/S0031182002002846)
Wippersteg, V., Ribeiro, F., Liedtke, S., Kusel, J. and Grevelding, C. (2003) The uptake of Texas Red-BSA in the excretory system of schistosomes and its colocalisation with ER60 promoter-induced GFP in transiently transformed adult males. International Journal for Parasitology, 33, pp. 1139-1143. (doi: 10.1016/S0020-7519(03)00168-1)
Doenhoff, M., Kusel, J., Coles, G. and Cioli, D. (2002) Resistance of Schistosoma mansoni to praziquantel: is there a problem? Transactions of the Royal Society of Tropical Medicine and Hygiene, 96, pp. 465-469.
Sato, H., Kusel, J. and Thornhill, J. (2002) Functional visualization of the excretory system of adult Schistosoma mansoni by the fluorescent marker resorufin. Parasitology, 125, pp. 527-535. (doi: 10.1017/S0031182002002536)
Al-Adhami, B.H., Doenhoff, M., Thornhill, J., Akhkha, A., White, E. and Kusel, J.R. (2001) A study of some characteristics of individual clones of Schistosoma mansoni with emphasis on the biological and metabolic activities. Parasitology, 123(6), pp. 563-572. (doi: 10.1017/S0031182001008812)
Carneiro-Santos, P., Thornhill, J., Doenhoff, M., Hagan, P. and Kusel, J. (2001) Acidic vesicles of Schistosoma mansoni. Parasitology Research, 87, pp. 1001-1006.
Kusel, J. (2001) Climbing the tree of evolution. Trends in Parasitology, 17(8), pp. 398-399. (doi: 10.1016/S1471-4922(01)01956-0)
Books
Kusel, J.R., Vieira, L., Harnett, W., Ruppel, A., Cioli, D., Doenhoff, M., Colley, D., Coelho, P.M.Z., Wilson, R.A. and Cox, E.G. (2019) Personal Experiences During Discoveries in Schistosomiasis. Peertechz Publications. ISBN 9788194305736 (doi: 10.17352/ebook10114)