Dr Stuart Cobb

Visitor (School of Infection & Immunity)

R317 Level 3, West Medical Building, Glasgow G12 8QQ

Publications

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Number of items: 53.

2020

Bernardo, P., Cobb, S., Coppola, A., Tomasevic, L., Di Lazzaro, V., Bravaccio, C., Manganelli, F. and Dubbioso, R. (2020) Neurophysiological signatures of motor impairment in patients with Rett syndrome. Annals of Neurology, 87(5), pp. 763-773. (doi: 10.1002/ana.25712) (PMID:32129908)

2019

Turko, P., Groberman, K., Browa, F., Cobb, S. and Vida, I. (2019) Differential dependence of GABAergic and glutamatergic neurons on glia for the establishment of synaptic transmission. Cerebral Cortex, 29(3), pp. 1230-1243. (doi: 10.1093/cercor/bhy029) (PMID:29425353)

2017

Hector, R. D. et al. (2017) CDKL5 variants: improving our understanding of a rare neurological disorder. Neurology Genetics, 3(6), e200. (doi: 10.1212/NXG.0000000000000200) (PMID:29264392) (PMCID:PMC5732004)

Tillotson, R., Selfridge, J., Koerner, M. V., Gadalla, K. K.E. , Guy, J., De Sousa, D., Hector, R. D. , Cobb, S. R. and Bird, A. (2017) Radically truncated MeCP2 rescues Rett syndrome-like neurological defects. Nature, 550, pp. 398-401. (doi: 10.1038/nature24058) (PMID:29019980)

Bahey, N. G., Gadalla, K. K.E. , McGonigal, R. , Bailey, M. E.S. , Edgar, J. M. and Cobb, S. R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi: 10.1016/j.neuroscience.2017.06.061)

Gadalla, K. K.E. , Vudhironarit, T., Hector, R. D. , Sinnett, S., Bahey, N. G., Bailey, M. E.S. , Gray, S. J. and Cobb, S. R. (2017) Development of a novel AAV gene therapy cassette with improved safety features and efficacy in a mouse model of Rett syndrome. Molecular Therapy: Methods and Clinical Development, 5, pp. 180-190. (doi: 10.1016/j.omtm.2017.04.007) (PMID:28497075) (PMCID:PMC5423329)

Sinnett, S. E., Hector, R. D. , Gadalla, K. K.E. , Heindel, C., Chen, D., Zaric, V., Bailey, M. E.S. , Cobb, S. R. and Gray, S. J. (2017) Improved MECP2 gene therapy extends the survival of MeCP2-null mice without apparent toxicity after intracisternal delivery. Molecular Therapy: Methods and Clinical Development, 5, pp. 106-115. (doi: 10.1016/j.omtm.2017.04.006) (PMID:28497072) (PMCID:PMC5424572)

Hector, R. D. , Dando, O., Ritakari, T. E., Kind, P. C., Bailey, M. E.S. and Cobb, S. R. (2017) Characterisation of Cdkl5 transcript isoforms in rat. Gene, 603, pp. 21-26. (doi: 10.1016/j.gene.2016.12.001) (PMID:27940108)

Leonard, H., Cobb, S. and Downs, J. (2017) Clinical and biological progress over 50 years in Rett syndrome. Nature Reviews Neurology, 13(1), pp. 37-51. (doi: 10.1038/nrneurol.2016.186) (PMID:27934853)

2016

Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi: 10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)

Ross, P. D. et al. (2016) Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes. Human Molecular Genetics, 25(20), pp. 4389-4404. (doi: 10.1093/hmg/ddw269) (PMID:28173151) (PMCID:PMC5886038)

Hector, R. D. , Dando, O., Landsberger, N., Kilstrup-Nielsen, C., Kind, P. C., Bailey, M. E.S. and Cobb, S. R. (2016) Characterisation of CDKL5 transcript isoforms in human and mouse. PLoS ONE, 11(6), e0157758. (doi: 10.1371/journal.pone.0157758) (PMID:27315173) (PMCID:PMC4912119)

2015

Cobb, S. R. (2015) Cognitive disorders: deep brain stimulation for Rett syndrome. Nature, 526(7573), pp. 331-332. (doi: 10.1038/526331a) (PMID:26469040)

Trägårdh, J., Robb, G., Gadalla, K.K.E. , Cobb, S., Travis, C., Oppo, G.-L. and McConnell, G. (2015) Label-free imaging of thick tissue at 1550 nm using a femtosecond optical parametric generator. Optics Letters, 40(15), p. 3484. (doi: 10.1364/ol.40.003484) (PMID:26258338)

Booker, S. A., Pires, N., Cobb, S., Soares-da-Silva, P. and Vida, I. (2015) Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors. Neuropharmacology, 93, pp. 103-115. (doi: 10.1016/j.neuropharm.2015.01.019) (PMID:25656478)

Kamal, B., Russell, D., Payne, A., Constante, D., Tanner, K. E. , Isaksson, H., Mathavan, N. and Cobb, S. R. (2015) Biomechanical properties of bone in a mouse model of Rett syndrome. Bone, 71, pp. 106-114. (doi: 10.1016/j.bone.2014.10.008) (PMID:25445449) (PMCID:PMC4289916)

Saudargiene, A., Cobb, S. and Graham, B. P. (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus, 25(2), pp. 208-218. (doi: 10.1002/hipo.22365) (PMID:25220633)

Gadalla, K. K. E. , Ross, P. D., Hector, R. D. , Bahey, N. G., Bailey, M. E.S. and Cobb, S. R. (2015) Gene therapy for Rett syndrome: prospects and challenges. Future Neurology, 10(5), pp. 467-484. (doi: 10.2217/fnl.15.29)

2014

Gadalla, K. K.E. , Ross, P. D., Riddell, J. S. , Bailey, M. E.S. and Cobb, S. R. (2014) Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits. PLoS ONE, 9(11), e112889. (doi: 10.1371/journal.pone.0112889) (PMID:25392929) (PMCID:PMC4231076)

Graham, B. P., Saudargiene, A. and Cobb, S. (2014) Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity. Neural Computation, 26(10), pp. 2194-2222. (doi: 10.1162/NECO_a_00640) (PMID:25058697)

2013

Robinson, L., Plano, A., Cobb, S. and Riedel, G. (2013) Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice. Behavioural Brain Research, 250, pp. 148-156. (doi: 10.1016/j.bbr.2013.04.041)

Cobb, S.R. and Davies, C.H. (2013) Neurodevelopmental disorders. Neuropharmacology, 68, p. 1. (doi: 10.1016/j.neuropharm.2013.02.001)

McLeod, F., Ganley, R., Williams, L., Selfridge, J., Bird, A. and Cobb, S.R. (2013) Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome. Neuroscience, 231, pp. 195-205. (doi: 10.1016/j.neuroscience.2012.11.058) (PMID:23238573)

Gadalla, K.K.E. et al. (2013) Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice. Molecular Therapy, 21(1), pp. 18-30. (doi: 10.1038/mt.2012.200) (PMID:23011033) (PMCID:PMC3536818)

2012

Robinson, L. et al. (2012) Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome. Brain, 135(9), pp. 2699-2710. (doi: 10.1093/brain/aws096) (PMID:22525157) (PMCID:PMC3437019)

Barberan, S., Mcnair, K. , Iqbal, K., Smith, N.C., Prendergast, G.C., Stone, T.W. , Cobb, S.R. and Morris, B.J. (2012) Altered apoptotic responses in neurons lacking RhoB GTPase. European Journal of Neuroscience, 34(11), pp. 1737-1746. (doi: 10.1111/j.1460-9568.2011.07891.x)

2011

Weng, S.-M., Bailey, M. E.S. and Cobb, S. R. (2011) Rett syndrome: from bed to bench. Pediatrics and Neonatology, 52(6), pp. 309-316. (doi: 10.1016/j.pedneo.2011.08.002)

Gadalla, K.K.E., Bailey, M.E.S. and Cobb, S.R. (2011) MeCP2 and Rett syndrome: reversibility and potential avenues for therapy. Biochemical Journal, 439(1), pp. 1-14. (doi: 10.1042/BJ20110648)

Gan, J., Greenwood, S.M., Cobb, S.R. and Bushell, T.J. (2011) Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2. British Journal of Pharmacology, 163(5), pp. 984-994. (doi: 10.1111/j.1476-5381.2011.01293.x)

Weng, S.-M., McLeod, F., Bailey, M.E.S. and Cobb, S.R. (2011) Synaptic plasticity deficits in an experimental model of Rett Syndrome: LTP saturation and its pharmacological reversal. Neuroscience, 180, pp. 314-321. (doi: 10.1016/j.neuroscience.2011.01.061)

Nathan, P.J., Cobb, S.R., Lu, B., Bullmore, E.T. and Davies, C.H. (2011) Studying synaptic plasticity in the human brain and opportunities for drug discovery. Current Opinion in Pharmacology, 11(5), pp. 540-548. (doi: 10.1016/j.coph.2011.06.008)

Poland, S.P., Wright, A.J., Cobb, S.R., Vijverberg, J.C. and Girkin, J.M. (2011) A demonstration of the effectiveness of a single aberration correction per optical slice in beam scanned optically sectioning microscopes. Micron, 42(4), pp. 318-323. (doi: 10.1016/j.micron.2010.05.018)

2010

Cobb, S., Guy, J. and Bird, A. (2010) Reversibility of functional deficits in experimental models of Rett syndrome. Biochemical Society Transactions, 38(2), pp. 498-506. (doi: 10.1042/BST0380498)

McNair, K., Spike, R., Guilding, C., Prendergast, G.C., Stone, T.W., Cobb, S.R. and Morris, B.J. (2010) A role for RhoB in synaptic plasticity and the regulation of neuronal morphology. Journal of Neuroscience, 30(9), pp. 3508-3517. (doi: 10.1523/JNEUROSCI.5386-09.2010) (PMID:20203211) (PMCID:PMC6634083)

Cutsuridis, V., Cobb, S.R. and Graham, B.P. (2010) Encoding and retrieval in a model of the hippocampal CA1 microcircuit. Hippocampus, 20(3), pp. 423-446. (doi: 10.1002/hipo.20661)

Cutsuridis, V., Graham, B., Cobb, S.R. and Vida, I. (2010) Hippocampal Microcircuits: A Computational Modelers' Resource Book. Series: Springer Series in Computational Neuroscience, 5. Springer. ISBN 978-1-4419-0995-4

2009

Cutsuridis, V., Cobb, S.R. and Graham, B.P. (2009) How Bursts Shape the STDP Curve in the Presence/Absence of GABAergic Inhibition. In: Artificial Neural Networks – ICANN 2009, pp. 229-238. (doi: 10.1007/978-3-642-04274-4_24)

2008

Goodwin, R.J.A., Dungworth, J.C., Cobb, S.R. and Pitt, A.R. (2008) Time-dependent evolution of tissue markers by MALDI-MS imaging. Proteomics, 8(18), pp. 3801-3808. (doi: 10.1002/pmic.200800201)

Cobb, S.R. and Pitt, A.R. (2008) Proteomics in the study of hippocampal plasticity. Expert Review of Proteomics, 5(3), pp. 393-404. (doi: 10.1586/14789450.5.3.393)

2007

Yau, J.L.W., Mcnair, K. , Noble, J., Brownstein, D., Hibberd, C., Morton, N., Mullins, J.J., Morris, R.G.M., Cobb, S. and Seckl, J.R. (2007) Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice. Journal of Neuroscience, 27(39), pp. 10487-10496. (doi: 10.1523/JNEUROSCI.2190-07.2007)

Guy, J., Gan, J., Selfridge, J., Cobb, S. and Bird, A. (2007) Reversal of neurological defects in a mouse model of Rett syndrome. Science, 315, pp. 1143-1147. (doi: 10.1126/science.1138389)

McNair, K., Broad, J., Riedel, G., Davies, C. and Cobb, S. (2007) Global changes in the hippocampal proteome following exposure to an enriched environment. Neuroscience, 145, pp. 413-422. (doi: 10.1016/j.neurosciece.2006.12.033)

Shelbourne, P., Coote, E., Dadak, S. and Cobb, S. (2007) Normal electrical properties of hippocampal neurons modelling early Huntington disease pathogenesis. Brain Research, 1139, pp. 226-234. (doi: 10.1016/j.brainres.2006.12.091)

Yau, J., McNair, K., Noble, J., Brownstein, D., Hibberd, C., Morton, N., Mullins, J., Morris, R., Cobb, S. and Seckl, J. (2007) Enhanced hippocampal long-term potentiation and spatial learning in aged 11 beta-hydroxysteroid dehydrogenase type 1 knock-out mice. Journal of Neuroscience, 27, pp. 10487-10496. (doi: 10.1523/JNEUROSCI.2190-07.2007)

2006

Bushell, T., Plevin, R., Cobb, S. and Irving, A. (2006) Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes. Neuropharmacology, 50, pp. 714-725. (doi: 10.1016/j.neuropharm.2005.11.024)

Gill, C., Brown, J., Shivji, N., Lappin, S., Farmer, C., Randall, A., McNaughton, N., Cobb, S. and Davies, C. (2006) Inhibition of I-h reduces epileptiform activity in rodent hippocampal slices. Synapse, 59, pp. 308-316. (doi: 10.1002/syn.20242)

McNair, K., Davies, C. and Cobb, S. (2006) Plasticity-related regulation of the hippocampal proteome. European Journal of Neuroscience, 23, pp. 575-580. (doi: 10.1111/j.1460-9568.2005.04542.x)

Widmer, H., Ferrigan, L., Davies, C. and Cobb, S. (2006) Evoked slow muscarinic acetylcholinergic synaptic potentials in rat hippocarnpal interneurons. Hippocampus, 16, pp. 617-628. (doi: 10.1002/hipo.20191)

2005

Cobb, S.R. and Davies, C.H. (2005) Cholinergic modulation of hippocampal cells and circuits. Journal of Physiology, 562(1), pp. 81-88. (doi: 10.1113/jphysiol.2004.076539)

2003

Cobb, S., Larkman, P., Bulters, D., Oliver, L., Gill, C. and Davies, C. (2003) Activation of I-h is necessary for patterning of mGluR and mAChR induced network activity in the hippocampal CA3 region. Neuropharmacology, 44, pp. 293-303. (doi: 10.1016/S0028-3908(02)00405-7)

Roshan-Milani, S., Ferrigan, L., Khoshnood, M., Davies, C. and Cobb, S. (2003) Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation. Epilepsy Research, 56, pp. 51-65. (doi: 10.1016/j.eplepsyres.2003.08.005)

2002

Lanneau, C., Harries, M., Ray, A., Cobb, S., Randall, A. and Davies, C. (2002) Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus. Neuropharmacology, 43, pp. 131-140.

2001

Morton, R.A., Manuel, N.A., Bulters, D.O., Cobb, S.R. and Davies, C.H. (2001) Regulation of muscarinic acetylcholine receptor-mediated synaptic responses by GABA(B) receptors in the rat hippocampus. Journal of Physiology, 535, pp. 757-766. (doi: 10.1111/j.1469-7793.2001.00757.x)

This list was generated on Thu Jun 8 22:09:25 2023 BST.

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