Dr Vladimira Moulisova
- Affiliate (School of Engineering)
I work as a Research Associate in the MiMe group at the Biomedical Engineering Research Division of the School of Engineering. I have a Master Degree in Biochemistry from the Charles University in Prague, and I obtained a PhD in Molecular and Cell Biology at the University of South Bohemia (Czech Republic) in 2006. Before joining the School or Engineering in 2013, I spent 6 years doing research at the School of Medical, Veterinary and Life Sciences at the University of Glasgow.
My current research interest is focused on vascularization processes applicable in tissue engineering and regenerative medicine. Although there have been significant advances in engineering tissues for transplantation (e.g. bone, muscle or neural grafts), vascularization of such tissues is still a challenge. Deeper knowledge about vessel formation and regeneration, particularly related to new biocompatible materials, is necessary for development of suitable transplants. Rather than preparing a pre-vascularized graft, I study synthetic biomaterials that can stimulate natural revascularization in situ using only specific proteins of extracellular matrix and very low concentrations of growth factors. For many applications, this simplified platform would be not only cheaper and more robust than a fully grown tissue graft but would also enable the implanted system to help the organism to self-repair. I am also currently collaborating with Polytechnic University of Valencia on the regenerative processes of cartilage.
My previous research has spanned several topics, from mechanisms of chemical carcinogenesis and the role CYPs across hepatocyte membrane transport and oxidative damage to mechanisms of aging and regenerative effect of microvesicles isolated from stem cells.
Co-supervision of PhD students:
- Nadira Salah (Regeneration of epithelial tissues: Reconstructing bronchial and fallopian tube mucosae; expected 2018)
Lab supervision of MSc students:
- Jake Hay (The interaction of genetically modified lactococcus lactis with nanotopography to modulate cell differentiation; 2014)
- Mohammed Al-Jarsha (In vitro investigation of a new biomaterial coating for titanium implants incorporating rhBMP-7; 2015)
Lab supervision of BSc students:
- Aisha Abdullahi (Biomaterials for vascularization: Endothelial cell focal adhesions study; 2015)