Technical innovation for high-throughput microfluidic characterisation of biomimetic vesicles makes cover of Lab on a Chip

Issued: Fri, 23 May 2014 11:04:00 BST

The article 'Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles' is featured as the front cover of the journal Lab-on-a-chip. The technique described enables to dramatically increase the throughput of research into lipid–lipid and lipid–peptide interactions in in vivo-like configurations. These interactions are involved in several key cellular processes, including membrane signal transduction, membrane-protein structure and function and vesicle trafficking. Conventionally, this research is carried out in cell-like lipid vesicles, that are examined one by one, using labour intensive and time-consuming micromanipulation technique.

Here we utilise the fine control of microfluidic technologies to interrogate a large number of vesicles in one experiment, under controlled flow conditions. In addition, the device presented does not require extensive technical expertise.

The articel was first published online on 4th April 2014 and can be accessed from the link;

Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles

03 June 2014 - Update - LOC has selected this article as a HOT article making it free to access, for more information see the LOC blog;
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