Dr Chris Nile

  • Senior Lecturer in Oral Biosciences (Dental School)
  • Associate (Institute of Infection Immunity & Inflammation)

Research interests

The interactions between microbiota and the host play an important role in both health and disease. These interactions perpetuate an inflammatory response which is important for maintaining a homeostatic relationship between the host and commensal microbiota and also for the protection against pathogenic organisms. However, many pathologies result from a sub-optimal or excessive inflammatory response. Therefore, it is important that the inflammatory response is tightly regulated.

Chris is interested in how microorganisms can initiate the inflammatory response and the host mechanisms that regulate this process. Specifically, Chris is interested in endogenous molecules with anti-inflammatory and pro-resolution properties and their role in microbiota mediated pathologies of humans and companion animals. Furthermore, Chris is interested in the potential role of these endogenous molecules in modulating the growth and survival of microorganisms; as well as their ability to form biofilms. 

 Acetylcholine

Chris is interested in the basic non-neuronal cholinergic systems that operate within mucosal tissues and the role these play in health and disease. Specifically, Chris is interested in the role acetylcholine and its receptors play in modulating the immune response and the role they play in the pathogenesis of infectious disease. Selected publications include:

Rajendran R, Borghi E, Falleni M, Perdoni F, Tosi D, Lappin DF, O'Donnell L, Greetham D, Ramage G, Nile C. (2015) Acetylcholine protects against Candida albicans infection by inhibiting biofilm formation and promoting haemocyte function in a Galleria mellonella infection model. Eukaryotic Cell, 14(8):834-44. (doi: 10.1128/EC.00067-15). 

Macpherson, A., Zoheir, N., Awang, R. A., Culshaw, S., Ramage, G., Lappin, D. F. and Nile, C.J. (2014) The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes. Inflammation Research, 63 (7). pp. 557-568. ISSN 1023-3830 (doi:10.1007/s00011-014-0725-5)

Zoheir, N., Lappin, D.F., and Nile, C.J. (2012) Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease? Inflammation Research, 61 (9). pp. 915-926. ISSN 1023-3830 (doi:10.1007/s00011-012-0513-z)

Interleukin-17E

Chris is interested in the role of IL-17 family cytokines in health and disease; in particular Interleukin 17E (IL-25).  IL-17E exhibits contrasting biological functions to IL-17A and is known to also acts as negative regulator of inflammatory responses as well as a promotor of resolution and healing and repair. A focus of Chris’s research is to investigate the role of IL-17E in regulating immune responses in infectious disease. Selected publications include:

 

Nile CJ, Apatzidou DA, Awang RA, Riggio MP, Kinane DF, Lappin DF. (2016) The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio.Clinical Oral Investigations (epub ahead of print)

Azman R, Lappin D, MacPherson A, Riggio M, Robertson D, Hodge P, Ramage G, Culshaw S, Preshaw P, Taylor J andNile CJ. (2014) Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity. Inflammation Research, 63 (12). pp. 1001-1012. ISSN 1023-3830 (doi:10.1007/s00011-014-0776-7)

Gümüş, P., Buduneli, E., Bıyıkoğlu, B., Aksu, K., Saraç, F., Nile, C., Lappin, D., and Buduneli, N. (2013) Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, interleukin-17 in rheumatoid arthritis and osteoporosis Patients With Periodontal Disease. Journal of periodontology, 84 (11). pp. 1627-1637. ISSN 0022-3492 (doi:10.1902/jop.2013.120595)

Özçaka, Ö., Buduneli, N., Ceyhan, B.O., Akcali, A., Hannah, V., Nile, C., and Lappin, D.F. (2013) Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation? Journal of Periodontology, 84 (12). pp. 1827-1837. ISSN 0022-3492 (doi:10.1902/jop.2013.120483)

Current Students

Christopher Delaney (PhD student)

Khadijah Mohammad O Baik (PhD student)

Elizabeth Loffill (PhD student)

Hasanain Kahtan Abdulkhalik Alalwan (PhD student)

Sheeba Thomas (PhD student)


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Do interkingdom polymicrobial biofilms impede the treatment of apical periodontitis?
    British Endodontic Society
    2018 - 2020
     
  • Development of a novel in vitro model to investigate the role of pathogens in the aetiology of feline chronic gingiovostomatitis and to test therapeutic interventions
    Petplan Charitable Trust
    2015 - 2019
     
  • Development of bioinformatic analysis pipelines to integrate transcriptomic and metabolomic data to map the alpha 7 nicotinic receptor... (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     
  • Evaluating the clinical outcomes of denture stomatitis patients: impact of denture cleansers and biological properties of Candida spp
    Oral and Dental Research Trust
    2013 - 2014
     
  • Development of a novel antimicrobial and anti-inflammatory oral healthcare product to prevent or treat periodontal disease
    Oral and Dental Research Trust
    2013 - 2014
     
  • Do age-related changes in acetylcholine production by oral keratinocytes impact on the pathogenesis of peridontal disease?
    Dunhill Medical Trust
    2012 - 2014
     
  • What is the role of Interleukin-33 in periodontal disease
    Royal College of Surgeons of Edinburgh
    2011 - 2012
     
  • What is the role of IL-33 in periodontal disease?
    Oral and Dental Research Trust
    2011 - 2012
     
  • Does IL-17E have a regulatory role in periodontal disease via effects on oral keratinocytes?
    Tenovus Scotland
    2011 - 2012
     

Teaching

Chris is currently BDS1 co-ordinator at the Dental School. In this role he is responsible for the management, coordination and oversees administration and delivery of teaching and learning, assessment and quality assurance for the BDS1 course

Chris is an active member of the Dental School teaching team and is academic lead for the teaching of pathology. As head of pathology teaching, Chris co-ordinates the activity of 4 academics (clinical and non-clinical) in the delivery of 15 lectures, 40 small group tutorials and 2 practical classes; of which Chris is directly responsible for the delivery of 12 lectures (e.g. Introduction to pathology, Defence cells, Innate immunity, Adaptive immunity and Healing and Repair), 10 small group tutorials and 2 practical classes.

Chris is chief advisor at the Dental School. As Chief Advisor, Chris co-ordinates 5 members of the advisor team to provide general pastoral care to BDS students. In addition, the role includes supporting students in their cases for presentation to Progress Committee and Fitness to Practise hearings.

As well as undergraduate teaching activities; Chris also continues to support the University of Glasgow’s postgraduate taught (PGT) degree programmes. Chris was deputy lead for Translational Medical Sciences programme and has played a key role in the development of the new Oral Sciences MSc programme which will begin in 2017 subject to Senate approval. Chris also plays a key role in the delivery of specific courses allied to the Biomedical Sciences PGT programmes; including Translational Immunology and Translational Medical Research Approaches. 


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2004
Number of items: 41.

2019

Delaney, C. et al. (2019) Interkingdom interactions on the denture surface: implications for oral hygiene. Biofilm, (Accepted for Publication)

Nile, C. et al. (2019) Repurposing Pilocarpine Hydrochloride for the treatment of Candida albicans infections. mSphere, 4(1), e00689-18. (doi:10.1128/mSphere.00689-18) (PMID:30674648) (PMCID:PMC6344604)

2018

Apatzidou, D. A., Iskas, A., Konstantinidis, A., Alghamdi, A. M., Tumelty, M., Lappin, D. F. and Nile, C. J. (2018) Clinical associations between acetylcholine levels and cholinesterase activity in saliva and gingival crevicular fluid and periodontal diseases. Journal of Clinical Periodontology, 45(10), pp. 1173-1183. (doi:10.1111/jcpe.12989) (PMID:30022504)

Delaney, C., Kean, R., Short, B., Tumelty, M., McLean, W., Nile, C. and Ramage, G. (2018) Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections? Current Clinical Microbiology Reports, 5(3), pp. 190-200. (doi:10.1007/s40588-018-0100-3)

Apatzidou, D.A., Nile, C. , Bakopoulou, A., Konstantinidis, A. and Lappin, D.F. (2018) Stem cell-like populations and immunoregulatory molecules in periodontal granulation tissue. Journal of Periodontal Research, 53(4), pp. 610-621. (doi:10.1111/jre.12551) (PMID:29687448)

Alalwan, H., Nile, C. J. , Rajendran, R., McKerlie, R. , Reynolds, P. , Gadegaard, N. and Ramage, G. (2018) Nanoimprinting of biomedical polymers reduces candidal physical adhesion. Nanomedicine: Nanotechnology, Biology and Medicine, 14(3), pp. 1045-1049. (doi:10.1016/j.nano.2018.01.011) (PMID:29408656)

2017

Gürlek, Ö., Gümüş, P., Nile, C. J. , Lappin, D. F. and Buduneli, N. (2017) Biomarkers and bacteria around implants and natural teeth in the same individuals. Journal of Periodontology, 88(8), pp. 752-761. (doi:10.1902/jop.2017.160751) (PMID:28440740)

Alalwan, H., Rajendran, R., Lappin, D. F., Combet, E. , Shahzad, M., Robertson, D., Nile, C. J. , Williams, C. and Ramage, G. (2017) The anti-adhesive effect of curcumin on Candida albicans biofilms on denture materials. Frontiers in Microbiology, 8, 659. (doi:10.3389/fmicb.2017.00659) (PMID:28473808) (PMCID:PMC5397414)

Thomas, S., Lappin, D. F., Spears, J., Bennett, D., Nile, C. and Riggio, M. P. (2017) Prevalence of feline calicivirus in cats with odontoclastic resorptive lesions and chronic gingivostomatitis. Research in Veterinary Science, 111, pp. 124-126. (doi:10.1016/j.rvsc.2017.02.004) (PMID:28235708)

Greetham, D., Lappin, D. F., Rajendran, R., O'Donnell, L., Sherry, L., Ramage, G. and Nile, C. (2017) The application of phenotypic microarray analysis to anti-fungal drug development. Journal of Microbiological Methods, 134, pp. 35-37. (doi:10.1016/j.mimet.2017.01.004) (PMID:28082175)

O'Donnell, L. E., Alalwan, H. K. A., Kean, R., Calvert, G., Nile, C. J. , Lappin, D. J., Robertson, D., Williams, C., Ramage, G. and Sherry, L. (2017) Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity. Journal of Medical Microbiology, 66(1), pp. 54-60. (doi:10.1099/jmm.0.000419) (PMID:28032543)

2016

Nile, C.J. , Apatzidou, D.A., Awang, R.A., Riggio, M.P. , Kinane, D.F. and Lappin, D.F. (2016) The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio. Clinical Oral Investigations, 20(9), pp. 2529-2537. (doi:10.1007/s00784-016-1749-8) (PMID:26888221)

Sherry, L., Lappin, G., O'Donnell, L. E., Millhouse, E., Millington, O. R., Bradshaw, D. J., Axe, A. S., Williams, C., Nile, C. J. and Ramage, G. (2016) Viable compositional analysis of an eleven species oral polymicrobial biofilm. Frontiers in Microbiology, 7, 912. (doi:10.3389/fmicb.2016.00912) (PMID:27375612) (PMCID:PMC4902011)

O'Donnell, L. E. et al. (2016) Dentures are a reservoir for respiratory pathogens. Journal of Prosthodontics, 25(2), pp. 99-104. (doi:10.1111/jopr.12342) (PMID:26260391)

Rajendran, R., Sherry, L., Nile, C. , Sherriff, A. , Johnson, E., Hanson, M., Williams, C., Munro, C., Jones, B. and Ramage, G. (2016) Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection – Scotland, 2012-2013. Clinical Microbiology and Infection, 22(1), pp. 87-93. (doi:10.1016/j.cmi.2015.09.018) (PMID:26432192)

2015

Lappin, D. F., Robertson, D., Hodge, P., Treagus, D., Awang, R. A., Ramage, G. and Nile, C. J. (2015) The influence of glycated hemoglobin on the cross susceptibility between type 1 diabetes mellitus and periodontal disease. Journal of Periodontology, 86(11), pp. 1249-1259. (doi:10.1902/jop.2015.150149) (PMID:26252750)

O'Donnell, L. E., Millhouse, E., Sherry, L., Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi:10.1093/femsyr/fov077) (PMID:26298018)

Rajendran, R., Borghi, E., Falleni, M., Perdoni, F., Tosi, D., Lappin, D.F., O'Donnell, L., Greetham, D., Ramage, G. and Nile, C. (2015) Acetylcholine protects against Candida albicans infection by inhibiting biofilm formation and promoting hemocyte function in a Galleria mellonella infection model. Eukaryotic Cell, 14(8), pp. 834-844. (doi:10.1128/ec.00067-15) (PMID:26092919)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi:10.1177/0022034515577815) (PMID:25808546)

Borghi, E., Morace, G., Borgo, F., Rajendran, R., Sherry, L., Nile, C. and Ramage, G. (2015) New strategic insights into managing fungal biofilms. Frontiers in Microbiology, (doi:10.3389/fmicb.2015.01077)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi:10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

2014

Azman, R. et al. (2014) Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity. Inflammation Research, 63(12), pp. 1001-1012. (doi:10.1007/s00011-014-0776-7) (PMID:25369802)

Sherry, L. et al. (2014) Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity. BMC Microbiology, 14(1), p. 182. (doi:10.1186/1471-2180-14-182)

Jitprasertwong, P., Jaedicke, K. M., Nile, C. J. , Preshaw, P. and Taylor, J. J. (2014) Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1. Cytokine, 65(2), pp. 222-230. (doi:10.1016/j.cyto.2013.10.008)

Macpherson, A., Zoheir, N., Awang, R. A., Culshaw, S. , Ramage, G. , Lappin, D. F. and Nile, C. J. (2014) The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes. Inflammation Research, 63(7), pp. 557-568. (doi:10.1007/s00011-014-0725-5)

Rajendran, R., Sherry, L., Lappin, D. F., Nile, C. J. , Smith, K., Williams, C., Munro, C. A. and Ramage, G. (2014) Extracellular DNA release confers heterogeneity in Candida albicans biofilm formation. BMC Microbiology, 14, 303. (doi:10.1186/s12866-014-0303-6) (PMID:25476750) (PMCID:PMC4262977)

2013

Özçaka, Ö., Buduneli, N., Ceyhan, B.O., Akcali, A., Hannah, V., Nile, C. and Lappin, D.F. (2013) Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation? Journal of Periodontology, 84(12), pp. 1827-1837. (doi:10.1902/jop.2013.120483)

Nile, C.J. , Sherrabeh, S., Ramage, G. and Lappin, D.F. (2013) Comparison of circulating tumour necrosis factor superfamily cytokines in periodontitis patients undergoing supportive therapy: a case-controlled cross-sectional study comparing smokers and non-smokers in health and disease. Journal of Clinical Periodontology, 40(9), pp. 875-882. (doi:10.1111/jcpe.12134)

Sherry, L., Millhouse, E., Lappin, D. F., Murray, C., Culshaw, S. , Nile, C. J. and Ramage, G. (2013) Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections. BMC Oral Health, 13, p. 47. (doi:10.1186/1472-6831-13-47)

Gümüş, P., Buduneli, E., Bıyıkoğlu, B., Aksu, K., Saraç, F., Nile, C. , Lappin, D. and Buduneli, N. (2013) Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, interleukin-17 in rheumatoid arthritis and osteoporosis patients with periodontal disease. Journal of Periodontology, 84(11), pp. 1627-1637. (doi:10.1902/jop.2013.120595)

2012

Zoheir, N., Lappin, D.F. and Nile, C.J. (2012) Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease? Inflammation Research, 61(9), pp. 915-926. (doi:10.1007/s00011-012-0513-z)

Nile, C.J. and Gillespie, J.I. (2012) Interactions between cholinergic and prostaglandin signaling elements in the urothelium: Role for muscarinic type 2 receptors. Urology, 79(1), 240.e17-240.e23. (doi:10.1016/j.urology.2011.08.029)

2011

Grol, S., Nile, C.J. , Martinez-Martinez, P., van Koeveringe, G., de Wachter, S., de Vente, J. and Gillespie, J.I. (2011) M3 muscarinic receptor like immuno-reactivity (M3-IR) in sham-operated and obstructed guinea pig bladders. Journal of Urology, 185(5), pp. 1959-1966. (doi:10.1016/j.juro.2010.12.031)

2010

Nile, C.J. , Barksby, E., Jitprasertwong, P., Preshaw, P.M. and Taylor, J.J. (2010) Expression and regulation of interleukin-33 in human monocytes. Immunology, 130(2), pp. 172-180. (doi:10.1111/j.1365-2567.2009.03221.x)

Nile, C.J. , de Vente, J. and Gillespie, J.I. (2010) Stretch independent regulation of prostaglandin E2 production within the isolated guinea-pig lamina propria. BJU International, 105(4), pp. 540-548. (doi:10.1111/j.1464-410X.2009.08705.x)

Howard, A., Townes, C., Milona, P., Nile, C.J. , Michailidis, G. and Hall, J. (2010) Expression and functional analyses of liver expressed antimicrobial peptide-2 (LEAP-2) variant forms in human tissues. Cellular Immunology, 261(2), pp. 128-133. (doi:10.1016/j.cellimm.2009.11.010)

2009

Barksby, H.E., Nile, C.J. , Jaedicke, K.M., Taylor, J.J. and Preshaw, P.M. (2009) Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide. Clinical and Experimental Immunology, 156(3), pp. 479-487. (doi:10.1111/j.1365-2249.2009.03920.x)

2008

Nile, C.J. , Read, R.C., Akil, M., Duff, G.W. and Wilson, A.G. (2008) Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis and Rheumatism, 58(9), pp. 2686-2693. (doi:10.1002/art.23758)

2006

Nile, C.J. , Townes, C.L., Hirst, B..H. and Hall, J. (2006) The novel avian protein, AWAK, contains multiple domains with homology to protease inhibitory modules. Molecular Immunology, 43(4), pp. 388-394. (doi:10.1016/j.molimm.2005.02.015)

2004

Nile, C.J. , Townes, C.L., Michailidis, G., Hirst, B.H. and Hall, J. (2004) Identification of chicken lysozyme g2 and its expression in the intestine. Cellular and Molecular Life Sciences, 61(21), pp. 2760-2766. (doi:10.1007/s00018-004-4345-z)

Townes, C.L., Michailidis, G., Nile, C.J. and Hall, J. (2004) Induction of cationic chicken liver-expressed antimicrobial peptide 2 in response to Salmonella enterica infection. Infection and Immunity, 72(12), pp. 6987-6993. (doi:10.1128/IAI.72.12.6987-6993.2004)

This list was generated on Sun Jun 16 21:56:58 2019 BST.
Jump to: Articles
Number of items: 41.

Articles

Delaney, C. et al. (2019) Interkingdom interactions on the denture surface: implications for oral hygiene. Biofilm, (Accepted for Publication)

Nile, C. et al. (2019) Repurposing Pilocarpine Hydrochloride for the treatment of Candida albicans infections. mSphere, 4(1), e00689-18. (doi:10.1128/mSphere.00689-18) (PMID:30674648) (PMCID:PMC6344604)

Apatzidou, D. A., Iskas, A., Konstantinidis, A., Alghamdi, A. M., Tumelty, M., Lappin, D. F. and Nile, C. J. (2018) Clinical associations between acetylcholine levels and cholinesterase activity in saliva and gingival crevicular fluid and periodontal diseases. Journal of Clinical Periodontology, 45(10), pp. 1173-1183. (doi:10.1111/jcpe.12989) (PMID:30022504)

Delaney, C., Kean, R., Short, B., Tumelty, M., McLean, W., Nile, C. and Ramage, G. (2018) Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections? Current Clinical Microbiology Reports, 5(3), pp. 190-200. (doi:10.1007/s40588-018-0100-3)

Apatzidou, D.A., Nile, C. , Bakopoulou, A., Konstantinidis, A. and Lappin, D.F. (2018) Stem cell-like populations and immunoregulatory molecules in periodontal granulation tissue. Journal of Periodontal Research, 53(4), pp. 610-621. (doi:10.1111/jre.12551) (PMID:29687448)

Alalwan, H., Nile, C. J. , Rajendran, R., McKerlie, R. , Reynolds, P. , Gadegaard, N. and Ramage, G. (2018) Nanoimprinting of biomedical polymers reduces candidal physical adhesion. Nanomedicine: Nanotechnology, Biology and Medicine, 14(3), pp. 1045-1049. (doi:10.1016/j.nano.2018.01.011) (PMID:29408656)

Gürlek, Ö., Gümüş, P., Nile, C. J. , Lappin, D. F. and Buduneli, N. (2017) Biomarkers and bacteria around implants and natural teeth in the same individuals. Journal of Periodontology, 88(8), pp. 752-761. (doi:10.1902/jop.2017.160751) (PMID:28440740)

Alalwan, H., Rajendran, R., Lappin, D. F., Combet, E. , Shahzad, M., Robertson, D., Nile, C. J. , Williams, C. and Ramage, G. (2017) The anti-adhesive effect of curcumin on Candida albicans biofilms on denture materials. Frontiers in Microbiology, 8, 659. (doi:10.3389/fmicb.2017.00659) (PMID:28473808) (PMCID:PMC5397414)

Thomas, S., Lappin, D. F., Spears, J., Bennett, D., Nile, C. and Riggio, M. P. (2017) Prevalence of feline calicivirus in cats with odontoclastic resorptive lesions and chronic gingivostomatitis. Research in Veterinary Science, 111, pp. 124-126. (doi:10.1016/j.rvsc.2017.02.004) (PMID:28235708)

Greetham, D., Lappin, D. F., Rajendran, R., O'Donnell, L., Sherry, L., Ramage, G. and Nile, C. (2017) The application of phenotypic microarray analysis to anti-fungal drug development. Journal of Microbiological Methods, 134, pp. 35-37. (doi:10.1016/j.mimet.2017.01.004) (PMID:28082175)

O'Donnell, L. E., Alalwan, H. K. A., Kean, R., Calvert, G., Nile, C. J. , Lappin, D. J., Robertson, D., Williams, C., Ramage, G. and Sherry, L. (2017) Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity. Journal of Medical Microbiology, 66(1), pp. 54-60. (doi:10.1099/jmm.0.000419) (PMID:28032543)

Nile, C.J. , Apatzidou, D.A., Awang, R.A., Riggio, M.P. , Kinane, D.F. and Lappin, D.F. (2016) The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio. Clinical Oral Investigations, 20(9), pp. 2529-2537. (doi:10.1007/s00784-016-1749-8) (PMID:26888221)

Sherry, L., Lappin, G., O'Donnell, L. E., Millhouse, E., Millington, O. R., Bradshaw, D. J., Axe, A. S., Williams, C., Nile, C. J. and Ramage, G. (2016) Viable compositional analysis of an eleven species oral polymicrobial biofilm. Frontiers in Microbiology, 7, 912. (doi:10.3389/fmicb.2016.00912) (PMID:27375612) (PMCID:PMC4902011)

O'Donnell, L. E. et al. (2016) Dentures are a reservoir for respiratory pathogens. Journal of Prosthodontics, 25(2), pp. 99-104. (doi:10.1111/jopr.12342) (PMID:26260391)

Rajendran, R., Sherry, L., Nile, C. , Sherriff, A. , Johnson, E., Hanson, M., Williams, C., Munro, C., Jones, B. and Ramage, G. (2016) Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection – Scotland, 2012-2013. Clinical Microbiology and Infection, 22(1), pp. 87-93. (doi:10.1016/j.cmi.2015.09.018) (PMID:26432192)

Lappin, D. F., Robertson, D., Hodge, P., Treagus, D., Awang, R. A., Ramage, G. and Nile, C. J. (2015) The influence of glycated hemoglobin on the cross susceptibility between type 1 diabetes mellitus and periodontal disease. Journal of Periodontology, 86(11), pp. 1249-1259. (doi:10.1902/jop.2015.150149) (PMID:26252750)

O'Donnell, L. E., Millhouse, E., Sherry, L., Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi:10.1093/femsyr/fov077) (PMID:26298018)

Rajendran, R., Borghi, E., Falleni, M., Perdoni, F., Tosi, D., Lappin, D.F., O'Donnell, L., Greetham, D., Ramage, G. and Nile, C. (2015) Acetylcholine protects against Candida albicans infection by inhibiting biofilm formation and promoting hemocyte function in a Galleria mellonella infection model. Eukaryotic Cell, 14(8), pp. 834-844. (doi:10.1128/ec.00067-15) (PMID:26092919)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi:10.1177/0022034515577815) (PMID:25808546)

Borghi, E., Morace, G., Borgo, F., Rajendran, R., Sherry, L., Nile, C. and Ramage, G. (2015) New strategic insights into managing fungal biofilms. Frontiers in Microbiology, (doi:10.3389/fmicb.2015.01077)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi:10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

Azman, R. et al. (2014) Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity. Inflammation Research, 63(12), pp. 1001-1012. (doi:10.1007/s00011-014-0776-7) (PMID:25369802)

Sherry, L. et al. (2014) Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity. BMC Microbiology, 14(1), p. 182. (doi:10.1186/1471-2180-14-182)

Jitprasertwong, P., Jaedicke, K. M., Nile, C. J. , Preshaw, P. and Taylor, J. J. (2014) Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1. Cytokine, 65(2), pp. 222-230. (doi:10.1016/j.cyto.2013.10.008)

Macpherson, A., Zoheir, N., Awang, R. A., Culshaw, S. , Ramage, G. , Lappin, D. F. and Nile, C. J. (2014) The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes. Inflammation Research, 63(7), pp. 557-568. (doi:10.1007/s00011-014-0725-5)

Rajendran, R., Sherry, L., Lappin, D. F., Nile, C. J. , Smith, K., Williams, C., Munro, C. A. and Ramage, G. (2014) Extracellular DNA release confers heterogeneity in Candida albicans biofilm formation. BMC Microbiology, 14, 303. (doi:10.1186/s12866-014-0303-6) (PMID:25476750) (PMCID:PMC4262977)

Özçaka, Ö., Buduneli, N., Ceyhan, B.O., Akcali, A., Hannah, V., Nile, C. and Lappin, D.F. (2013) Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation? Journal of Periodontology, 84(12), pp. 1827-1837. (doi:10.1902/jop.2013.120483)

Nile, C.J. , Sherrabeh, S., Ramage, G. and Lappin, D.F. (2013) Comparison of circulating tumour necrosis factor superfamily cytokines in periodontitis patients undergoing supportive therapy: a case-controlled cross-sectional study comparing smokers and non-smokers in health and disease. Journal of Clinical Periodontology, 40(9), pp. 875-882. (doi:10.1111/jcpe.12134)

Sherry, L., Millhouse, E., Lappin, D. F., Murray, C., Culshaw, S. , Nile, C. J. and Ramage, G. (2013) Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections. BMC Oral Health, 13, p. 47. (doi:10.1186/1472-6831-13-47)

Gümüş, P., Buduneli, E., Bıyıkoğlu, B., Aksu, K., Saraç, F., Nile, C. , Lappin, D. and Buduneli, N. (2013) Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, interleukin-17 in rheumatoid arthritis and osteoporosis patients with periodontal disease. Journal of Periodontology, 84(11), pp. 1627-1637. (doi:10.1902/jop.2013.120595)

Zoheir, N., Lappin, D.F. and Nile, C.J. (2012) Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease? Inflammation Research, 61(9), pp. 915-926. (doi:10.1007/s00011-012-0513-z)

Nile, C.J. and Gillespie, J.I. (2012) Interactions between cholinergic and prostaglandin signaling elements in the urothelium: Role for muscarinic type 2 receptors. Urology, 79(1), 240.e17-240.e23. (doi:10.1016/j.urology.2011.08.029)

Grol, S., Nile, C.J. , Martinez-Martinez, P., van Koeveringe, G., de Wachter, S., de Vente, J. and Gillespie, J.I. (2011) M3 muscarinic receptor like immuno-reactivity (M3-IR) in sham-operated and obstructed guinea pig bladders. Journal of Urology, 185(5), pp. 1959-1966. (doi:10.1016/j.juro.2010.12.031)

Nile, C.J. , Barksby, E., Jitprasertwong, P., Preshaw, P.M. and Taylor, J.J. (2010) Expression and regulation of interleukin-33 in human monocytes. Immunology, 130(2), pp. 172-180. (doi:10.1111/j.1365-2567.2009.03221.x)

Nile, C.J. , de Vente, J. and Gillespie, J.I. (2010) Stretch independent regulation of prostaglandin E2 production within the isolated guinea-pig lamina propria. BJU International, 105(4), pp. 540-548. (doi:10.1111/j.1464-410X.2009.08705.x)

Howard, A., Townes, C., Milona, P., Nile, C.J. , Michailidis, G. and Hall, J. (2010) Expression and functional analyses of liver expressed antimicrobial peptide-2 (LEAP-2) variant forms in human tissues. Cellular Immunology, 261(2), pp. 128-133. (doi:10.1016/j.cellimm.2009.11.010)

Barksby, H.E., Nile, C.J. , Jaedicke, K.M., Taylor, J.J. and Preshaw, P.M. (2009) Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide. Clinical and Experimental Immunology, 156(3), pp. 479-487. (doi:10.1111/j.1365-2249.2009.03920.x)

Nile, C.J. , Read, R.C., Akil, M., Duff, G.W. and Wilson, A.G. (2008) Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis and Rheumatism, 58(9), pp. 2686-2693. (doi:10.1002/art.23758)

Nile, C.J. , Townes, C.L., Hirst, B..H. and Hall, J. (2006) The novel avian protein, AWAK, contains multiple domains with homology to protease inhibitory modules. Molecular Immunology, 43(4), pp. 388-394. (doi:10.1016/j.molimm.2005.02.015)

Nile, C.J. , Townes, C.L., Michailidis, G., Hirst, B.H. and Hall, J. (2004) Identification of chicken lysozyme g2 and its expression in the intestine. Cellular and Molecular Life Sciences, 61(21), pp. 2760-2766. (doi:10.1007/s00018-004-4345-z)

Townes, C.L., Michailidis, G., Nile, C.J. and Hall, J. (2004) Induction of cationic chicken liver-expressed antimicrobial peptide 2 in response to Salmonella enterica infection. Infection and Immunity, 72(12), pp. 6987-6993. (doi:10.1128/IAI.72.12.6987-6993.2004)

This list was generated on Sun Jun 16 21:56:58 2019 BST.