Dr Andrew Freer

  • Honorary Senior Research Fellow (School of Chemistry)

telephone: 01413305945
email: Andrew.Freer@glasgow.ac.uk

Research interests

Research Interests

My current research focus is in the field of biomineralisation. This work stems from a lifetime in crystallography, latterly in protein crystallography where my focus lay in the structure elucidation of membrane and membrane associated proteins. In particular, the proteins of the myelin sheath and the antenna complex from photosynthetic bacteria. Experience gained from the isolation and purification of a number of target proteins has lead to a long term interdisciplinary collaboration with Prof. Maggie Cusack (GES) on understanding the exquisite biological control that takes place in invertebrate shell formation. Fascinated by the role that these key proteins play in biomineralisation has lead us to the development of microfluidics to directly study their influence on carbonate shell formation. We have now assembled the transcriptome for the mussel Mytilus edulis from which we can locate many of the common biomineralising proteins. The aspiration of this research is to mimic Nature in the quest to produce strong light-weight functional materials.

(See personal research page (http://www.chem.gla.ac.uk/staff/andy/) for further detail. 

Publication Highlights 

2011

Lombardi, C., Cocito, S., Gambi, M.C., Cisterna, B., Flach, Taylor, P.D., Keltie, K., Freer, A. & Cusack M. (2011) Effects of ocean acidification on growth, organic tissue and protein profile of the Mediteranean bryozoan Myriapora truncate. Aquat Biol, 13, 251-262.

2010

MacDonald, J., Freer A. & Cusack M. (2010) Attachment of oysters to natural substrata by biologically induced marine carbonate cement. Marine Biology, 157, 2087-2095. doi:10.1007/s00227-010-1476-7 >>

Bozhi, J., Cusack, M., Freer, A., Dobson,.P., Gadegaard, N. & Yin, H. (2010) Control of crystal polymorph in microfluidics using molluscan 29 kDa Ca2+ binding protein. Integrative Biology, 2, 528-535. doi:10.1039/C0IB00007H >>

MacDonald, J., Freer, A. & Cusack, M. (2010) Alignment of Crystallographic c-Axis throughout the four Distinct Microstructural Layers of the Oyster Crassostrea gigas. Crystal Growth and Design, 10 (3), pp1243-1246. doi:10.1021/cg901263p >>

Freer, A., Greenwood, D., Chung, P., Pannell, C. * Cusack, M. (2010) Aragonite-Prism Nacre Interface in Freshwater mussels Anodonta anatina (Linnaeus 1768) and Anodonta cygnea (L.1758). Crystal. Growth and Design, 10(1), pp 344-347. doi:10.1021/cg901265x >>

 

2009

Yin, H., Bozhi, J., Mosbahi,K., Dobson, P., Glidle, A., Gadegaard, N., Freer, A.,  Cooper, J. & Cusack M. (2009) Rapid Screening of biomineralisation using Microfluidics. Anal. Chem., 81 (1), 473-478 • DOI: 10.1021/ac801980b

 

2008

Cusack, M. & Freer, A. (2008). Biomineralisation: elemental and organic influence in carbonate systems. Chemical Reviews, v.108 (11), 4433-4454. doi:10.1021/cr078270o >>

Cusack, M., Dauphin, Y., Cuif, J-P., Salomé, M., Freer, A. & Yin, H. 2008. Micro-XANES mapping of sulphur and its association with magnesium and phosphorus in the shell of the brachiopod, Terebratulina retusa. Chemical Geology, v.253 (3-4), 172-179. doi:10.1016/j.chemgeo.2008.05.007 >>

Cusack, M., Parkinson, D., Freer, A., Pérez-Huerta, A., Fallick, A.E. & Curry, G.B. 2008. Oxygen isotope composition in Modoilus modiolus aragonite in the context of biological and crystallographic control. Mineralogical Magazine, 72 (2), 567-575.


Additional information

Awards

PhD (Glasgow) FRSC

 

 

Selected Recent Talks

"Isolation, extraction and crystallisation of membrane proteins". PEPC5 workshop, DESY, Hamburg 2003,2004, 2006, 2008.

Membrane protein workshop, ESRF Grenoble. 2005.

External Appointments & Positions

EMBO summer schools in protein extraction, purification and crystallization (PEPC3-5).

Lecturer, tutor and organiser for membrane protein section: DESY, Hamburg 2003, 2004, 2006, 2008.

PX group beamtime application coordinator with Diamond SRS (Oxford).

CASE coordinator with ESRF (Grebnoble)

 

 


Publications

List by: Type | Date

Jump to: 2011 | 2010 | 2008 | 2005 | 2004 | 2002 | 1988
Number of items: 13.

2011

Lombardi, C., Cocito, S., Gambi, M.C., Cisterna, B., Flach, F., Taylor, P.D., Keltie, K., Freer, A. and Cusack, M. (2011) Effects of ocean acidification on growth, organic tissue and protein profile of the Mediterranean ­bryo­zoan Myriapora truncata. Aquatic Biology, 13(3), pp. 251-262. (doi:10.3354/ab00376)

2010

MacDonald, J., Freer, A. and Cusack, M. (2010) Alignment of crystallographic c-axis throughout the four distinct microstructural layers of the oyster Crassostrea gigas. Crystal Growth and Design, 10(3), pp. 1243-1246. (doi:10.1021/cg901263p)

Freer, A., Greenwood, D., Chung, P., Pannell, C.L. and Cusack, M. (2010) Aragonite prism−nacre interface in freshwater mussels Anodonta anatina (Linnaeus, 1758) and Anodonta cygnea (L. 1758). Crystal Growth and Design, 10(1), pp. 344-347. (doi:10.1021/cg901265x)

MacDonald, J., Freer, A. and Cusack, M. (2010) Attachment of oysters to natural substrata by biologically induced marine carbonate cement. Marine Biology, 157, pp. 2087-2095. (doi:10.1007/s00227-010-1476-7)

2008

Cusack, M. and Freer, A. (2008) Biomineralization: elemental and organic influence in carbonate systems. Chemical Reviews, 108(11), pp. 4433-4454. (doi:10.1021/cr078270o)

Cusack, M. , Parkinson, D., Freer, A., Pérez-Huerta, A., Fallick, A.E. and Curry, G.B. (2008) Oxygen isotope composition in Modiolus modiolus aragonite in the context of biological and crystallographic control. Mineralogical Magazine, 72(2), pp. 569-577. (doi:10.1180/minmag.2008.072.2.569)

2005

Grant, S., Freer, A., Winfield, J., Gray, C. and Lennon, D. (2005) Introducing undergraduates to green chemistry: an interactive teaching exercise. Green Chemistry, 7, pp. 121-128. (doi:10.1039/b412664e)

Hunter, D.J.B., Macmaster, R., Roszak, A.W., Riboldi-Tunnicliffe, A., Griffiths, I.R. and Freer, A.A. (2005) Structure of myelin P2 protein from equine spinal cord. Acta Crystallographica. Section D: Biological Crystallography, 61(8), pp. 1067-1071. (doi:10.1107/S0907444905014162)

2004

Grant, S., Freer, A., Winfield, J., Gray, C., Overton, T. and Lennon, D. (2004) An undergraduate teaching exercise that explores contemporary issues in the manufacture of titanium dioxide on the industrial scale. Green Chemistry, 6, pp. 25-32. (doi:10.1039/b309878h)

2002

McLaughlin, M., Hunter, D., Thomson, C., Yool, D. , Kirkham, D., Freer, A. and Griffiths, I. (2002) Evidence for possible interactions between PLP and DM20 within the myelin sheath. Glia, 39(1), pp. 31-36. (doi:10.1002/glia.10091) (PMID:12112373)

Lennon, D. , Freer, A., Winfield, J., Landon, P. and Reid, N. (2002) An undergraduate teaching initiative to demonstrate the complexity and range of issues typically encountered in modern industrial chemistry. Green Chemistry, 4, pp. 181-187. (doi:10.1039/b202541h)

Wood, D., She, Y., Freer, A., Harauz, G. and Moscarello, M. (2002) Primary structure of equine myelin basic protein by mass spectrometry. Archives of Biochemistry and Biophysics, 405, pp. 137-146.

1988

Huneck, S., Connolly, J. D., Freer, A. A. and Rycroft, D. S. (1988) Grimaldone, a tricyclic sesquiterpenoid from Mannia fragrans. Crystal structure analysis. Phytochemistry, 27(5), pp. 1405-1407. (doi:10.1016/0031-9422(88)80204-8)

This list was generated on Fri Jul 19 07:25:01 2019 BST.
Jump to: Articles
Number of items: 13.

Articles

Lombardi, C., Cocito, S., Gambi, M.C., Cisterna, B., Flach, F., Taylor, P.D., Keltie, K., Freer, A. and Cusack, M. (2011) Effects of ocean acidification on growth, organic tissue and protein profile of the Mediterranean ­bryo­zoan Myriapora truncata. Aquatic Biology, 13(3), pp. 251-262. (doi:10.3354/ab00376)

MacDonald, J., Freer, A. and Cusack, M. (2010) Alignment of crystallographic c-axis throughout the four distinct microstructural layers of the oyster Crassostrea gigas. Crystal Growth and Design, 10(3), pp. 1243-1246. (doi:10.1021/cg901263p)

Freer, A., Greenwood, D., Chung, P., Pannell, C.L. and Cusack, M. (2010) Aragonite prism−nacre interface in freshwater mussels Anodonta anatina (Linnaeus, 1758) and Anodonta cygnea (L. 1758). Crystal Growth and Design, 10(1), pp. 344-347. (doi:10.1021/cg901265x)

MacDonald, J., Freer, A. and Cusack, M. (2010) Attachment of oysters to natural substrata by biologically induced marine carbonate cement. Marine Biology, 157, pp. 2087-2095. (doi:10.1007/s00227-010-1476-7)

Cusack, M. and Freer, A. (2008) Biomineralization: elemental and organic influence in carbonate systems. Chemical Reviews, 108(11), pp. 4433-4454. (doi:10.1021/cr078270o)

Cusack, M. , Parkinson, D., Freer, A., Pérez-Huerta, A., Fallick, A.E. and Curry, G.B. (2008) Oxygen isotope composition in Modiolus modiolus aragonite in the context of biological and crystallographic control. Mineralogical Magazine, 72(2), pp. 569-577. (doi:10.1180/minmag.2008.072.2.569)

Grant, S., Freer, A., Winfield, J., Gray, C. and Lennon, D. (2005) Introducing undergraduates to green chemistry: an interactive teaching exercise. Green Chemistry, 7, pp. 121-128. (doi:10.1039/b412664e)

Hunter, D.J.B., Macmaster, R., Roszak, A.W., Riboldi-Tunnicliffe, A., Griffiths, I.R. and Freer, A.A. (2005) Structure of myelin P2 protein from equine spinal cord. Acta Crystallographica. Section D: Biological Crystallography, 61(8), pp. 1067-1071. (doi:10.1107/S0907444905014162)

Grant, S., Freer, A., Winfield, J., Gray, C., Overton, T. and Lennon, D. (2004) An undergraduate teaching exercise that explores contemporary issues in the manufacture of titanium dioxide on the industrial scale. Green Chemistry, 6, pp. 25-32. (doi:10.1039/b309878h)

McLaughlin, M., Hunter, D., Thomson, C., Yool, D. , Kirkham, D., Freer, A. and Griffiths, I. (2002) Evidence for possible interactions between PLP and DM20 within the myelin sheath. Glia, 39(1), pp. 31-36. (doi:10.1002/glia.10091) (PMID:12112373)

Lennon, D. , Freer, A., Winfield, J., Landon, P. and Reid, N. (2002) An undergraduate teaching initiative to demonstrate the complexity and range of issues typically encountered in modern industrial chemistry. Green Chemistry, 4, pp. 181-187. (doi:10.1039/b202541h)

Wood, D., She, Y., Freer, A., Harauz, G. and Moscarello, M. (2002) Primary structure of equine myelin basic protein by mass spectrometry. Archives of Biochemistry and Biophysics, 405, pp. 137-146.

Huneck, S., Connolly, J. D., Freer, A. A. and Rycroft, D. S. (1988) Grimaldone, a tricyclic sesquiterpenoid from Mannia fragrans. Crystal structure analysis. Phytochemistry, 27(5), pp. 1405-1407. (doi:10.1016/0031-9422(88)80204-8)

This list was generated on Fri Jul 19 07:25:01 2019 BST.