Dr Holger Husi

Honorary Research Fellow (School of Cardiovascular & Metabolic Health)

Icams, Joseph Black Building, Room B2-21

Publications

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Number of items: 75.

2022

Stalmach, A., Boehm, I., Fernandes, M., Rutter, A., Skipworth, R. J. E. and Husi, H. (2022) Gene ontology (GO)-driven inference of candidate proteomic markers associated with muscle atrophy conditions. Molecules, 27(17), 5514. (doi: 10.3390/molecules27175514)

Cervantes-Gracia, K., Chahwan, R. and Husi, H. (2022) Integrative OMICS data-driven procedure using a derivatized meta-analysis approach. Frontiers in Genetics, 13, 828786. (doi: 10.3389/fgene.2022.828786) (PMID:35186042) (PMCID:PMC8855827)

2020

Ross, J. A., Vissers, J. P.C., Nanda, J., Stewart, G. D., Husi, H., Habib, F. K., Hammond, D. E. and Gethings, L. A. (2020) The influence of hypoxia on the prostate cancer proteome. Clinical Chemistry and Laboratory Medicine, 58(6), pp. 980-993. (doi: 10.1515/cclm-2019-0626) (PMID:31940282)

2018

Fernandes, M., Patel, A. and Husi, H. (2018) C/VDdb: a multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD). PLoS ONE, 13(11), e0207371. (doi: 10.1371/journal.pone.0207371) (PMID:30419069) (PMCID:PMC6231654)

Cervantes-Gracia, K. and Husi, H. (2018) Integrative analysis of Multiple Sclerosis using a systems biology approach. Scientific Reports, 8, 5633. (doi: 10.1038/s41598-018-24032-8) (PMID:29618802) (PMCID:PMC5884799)

Fernandes, M., Cisek, K. and Husi, H. (2018) Molecular model for CKD. In: Vlahou, A., Mischak, H., Zoidakis, J. and Magni, F. (eds.) Integration of Omics Approaches and Systems Biology for Clinical Applications. Series: Wiley series on mass spectrometry. John Wiley & Sons, Inc.: Hoboken, NJ, pp. 327-346. ISBN 9781119181149 (doi: 10.1002/9781119183952.ch20)

Krochmal, M., Cisek, K. and Husi, H. (2018) Database creation and utility. In: Vlahou, A., Mischak, H., Zoidakis, J. and Magni, F. (eds.) Integration of Omics Approaches and Systems Biology for Clinical Applications. Series: Wiley series on mass spectrometry. John Wiley & Sons, Inc.: Hoboken, NJ, pp. 286-300. ISBN 9781119181149 (doi: 10.1002/9781119183952.ch17)

Krochmal, M. and Husi, H. (2018) Knowledge discovery and data mining. In: Vlahou, A., Mischak, H., Zoidakis, J. and Magni, F. (eds.) Integration of Omics Approaches and Systems Biology for Clinical Applications. Series: Wiley series on mass spectrometry. John Wiley & Sons, Inc.: Hoboken, NJ, pp. 233-247. ISBN 9781119181149 (doi: 10.1002/9781119183952.ch14)

2017

Krochmal, M. et al. (2017) Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy. Scientific Reports, 7, 15160. (doi: 10.1038/s41598-017-15359-9) (PMID:29123184) (PMCID:PMC5680307)

Ortiz, A. et al. (2017) Mitogen-activated protein kinase 14 promotes AKI. Journal of the American Society of Nephrology, 28(3), pp. 823-836. (doi: 10.1681/ASN.2015080898) (PMID:27620989)

Cervantes Gracia, K., Llanas-Cornejo, D. and Husi, H. (2017) CVD and oxidative stress. Journal of Clinical Medicine, 6(2), 22. (doi: 10.3390/jcm6020022)

Albalat, A., Mullen, W. , Husi, H. and Mischak, H. (2017) Tissue proteomics in vascular disease. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer New York: New York, pp. 53-60. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_4)

Delles, C. and Husi, H. (2017) Systems biology approach in hypertension research. In: Touyz, R. M. and Schriffin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 69-79. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_6)

Fernandes, M. and Husi, H. (2017) Establishment of a integrative multi-omics expression database CKDdb in the context of chronic kidney disease (CKD). Scientific Reports, 7, 40367. (doi: 10.1038/srep40367) (PMID:28079125) (PMCID:PMC5227717)

2016

Fernandes, M. and Husi, H. (2016) Integrative systems biology investigation of Fabry disease. Diseases, 4(4), 35. (doi: 10.3390/diseases4040035)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Schönemeier, B. et al. (2016) Urinary peptide analysis differentiates pancreatic cancer from chronic pancreatitis. Pancreas, 45(7), pp. 1018-1026. (doi: 10.1097/mpa.0000000000000573) (PMID:26784907)

Carrick, E. et al. (2016) Development of a MALDI MS-based platform for early detection of acute kidney injury. Proteomics Clinical Applications, 10(7), pp. 732-742. (doi: 10.1002/prca.201500117) (PMID:27119821) (PMCID:PMC4950042)

Papadopoulos, T., Krochmal, M., Cisek, K., Fernandes, M., Husi, H., Stevens, R., Bascands, J.-L., Schanstra, J. P. and Klein, J. (2016) Omics databases on kidney disease: where they can be found and how to benefit from them. Clinical Kidney Journal, 9(3), pp. 343-352. (doi: 10.1093/ckj/sfv155) (PMID:27274817) (PMCID:PMC4886900)

Husi, H., Skipworth, R. J.E., Cronshaw, A., Fearon, K. C.H. and Ross, J. A. (2016) Proteomic identification of potential cancer markers in human urine using subtractive analysis. International Journal of Oncology, 48(5), pp. 1921-1932. (doi: 10.3892/ijo.2016.3424) (PMID:26984763)

Gwinner, W., Metzger, J., Husi, H. and Marx, D. (2016) Proteomics for rejection diagnosis in renal transplant patients: where are we now? World Journal of Transplantation, 6(1), pp. 28-41. (doi: 10.5500/wjt.v6.i1.28) (PMID:27011903) (PMCID:PMC4801803)

Krochmal, M., Fernandes, M., Filip, S., Pontillo, C., Husi, H., Zoidakis, J., Mischak, H., Vlahou, A. and Jankowski, J. (2016) PeptiCKDdb-peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease. Database, 2016, baw128. (doi: 10.1093/database/baw128) (PMID:27589965) (PMCID:PMC5009324)

Metzger, J., Mullen, W. , Husi, H., Stalmach, A. , Herget-Rosenthal, S., Groesdonk, H., Mischak, H. and Klingele, M. (2016) Acute kidney injury prediction in cardiac surgery patients by a urinary peptide pattern: a case-control validation study. Critical Care, 20, 157. (doi: 10.1186/s13054-016-1344-z) (PMID:27230659) (PMCID:PMC4882859)

2015

Glorieux, G. et al. (2015) New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis. Nephrology Dialysis Transplantation, 30(11), pp. 1842-1852. (doi: 10.1093/ndt/gfv254) (PMID:26160894)

Schanstra, J.P. et al. (2015) Diagnosis and prediction of CKD progression by assessment of urinary peptides. Journal of the American Society of Nephrology, 26(8), pp. 1999-2010. (doi: 10.1681/asn.2014050423) (PMID:25589610) (PMCID:PMC4520165)

Husi, H. and Human, C. (2015) Molecular determinants of acute kidney injury. Journal of Injury and Violence Research, 7(2), pp. 75-86. (doi: 10.5249/jivr.v7i2.615) (PMID:26104320) (PMCID:PMC4522318)

Husi, H., Skipworth, R. J.E., Cronshaw, A., Stephens, N. A., Wackerhage, H., Greig, C., Fearon, K. C.H. and Ross, J. A. (2015) Programmed cell death 6 interacting protein (PDCD6IP) and Rabenosyn-5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer. Proteomics Clinical Applications, 9(5-6), pp. 586-596. (doi: 10.1002/prca.201400111) (PMID:25644331)

MacDonald, A. J., Johns, N., Stephens, N. A., Greig, C. A., Ross, J. A., Small, A. C., Husi, H., Fearon, K. C.H. and Preston, T. (2015) Habitual myofibrillar protein synthesis is normal in patients with upper GI cancer cachexia. Clinical Cancer Research, 21(7), pp. 1734-1740. (doi: 10.1158/1078-0432.CCR-14-2004) (PMID:25370466)

Kuhla, B., Laeger, T., Husi, H. and Mullen, W. (2015) Cerebrospinal fluid prohormone processing and neuropeptides stimulating feed intake of dairy cows during early lactation. Journal of Proteome Research, 14(2), pp. 823-828. (doi: 10.1021/pr500872k) (PMID:25547169)

Bhat, A. et al. (2015) Protein interactome of muscle invasive bladder cancer. PLoS ONE, 10(1), e0116404. (doi: 10.1371/journal.pone.0116404) (PMID:25569276) (PMCID:PMC4287622)

Stalmach, A. , Husi, H., Mosbahi, K., Albalat, A., Mullen, W. and Mischak, H. (2015) Methods in capillary electrophoresis coupled to mass spectrometry for the identification of clinical proteomic/peptidomic biomarkers in biofluids. Methods in Molecular Biology, 1243, pp. 187-205. (doi: 10.1007/978-1-4939-1872-0_11)

2014

McSharry, C., Spears, M., Chaudhuri, R. , Cameron, E. J., Husi, H. and Thomson, N. C. (2014) Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. Journal of Allergy and Clinical Immunology, 134(5), pp. 1068-1075. (doi: 10.1016/j.jaci.2014.08.022) (PMID:25262463)

Robinson, S. W., Fernandes, M. and Husi, H. (2014) Current advances in systems and integrative biology. Computational and Structural Biotechnology Journal, 11(18), pp. 35-46. (doi: 10.1016/j.csbj.2014.08.007)

Husi, H., Van Agtmael, T. , Mullen, W. , Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C. , Perco, P. and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi: 10.1161/CIRCGENETICS.113.000196)

Frantzi, M. et al. (2014) Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C, pp. 44-58. (doi: 10.1016/j.jprot.2013.12.010)

Albalat, A., Husi, H., Stalmach, A. , Schanstra, J. P. and Mischak, H. (2014) Classical MALDI-MS versus CE-based ESI-MS proteomic profiling in urine for clinical applications. Bioanalysis, 6(2), pp. 247-66. (doi: 10.4155/bio.13.313)

Albalat, A., Husi, H., Siwy, J., Nally, J. E., McLaughlin, M. , Eckersall, P. D. and Mullen, W. (2014) Capillary electrophoresis interfaced with a mass spectrometer (CE-MS): technical considerations and applicability for biomarker studies in animals. Current Protein and Peptide Science, 15(1), pp. 23-35. (doi: 10.2174/1389203715666140221123920) (PMID:24555889)

Husi, H. and Albalat, A. (2014) Proteomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 147-179. ISBN 9780123868824 (doi: 10.1016/B978-0-12-386882-4.00009-8)

Koss, M. J. et al. (2014) Proteomics of vitreous humor of patients with exudative age-related macular degeneration. PLoS ONE, 9(5), e96895. (doi: 10.1371/journal.pone.0096895) (PMID:24828575) (PMCID:PMC4020801)

Nkuipou-Kenfack, E. et al. (2014) Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE, 9(5), e96955. (doi: 10.1371/journal.pone.0096955) (PMID:24817014) (PMCID:PMC4016198)

Stalmach, A. , Johnsson, H., McInnes, I. B. , Husi, H., Klein, J., Dakna, M., Mullen, W. , Mischak, H. and Porter, D. (2014) Identification of urinary peptide biomarkers associated with rheumatoid arthritis. PLoS ONE, 9(8), e104625. (doi: 10.1371/journal.pone.0104625) (PMID:25144639) (PMCID:PMC4140712)

2013

Albalat, A. et al. (2013) Improving peptide relative quantification in MALDI-TOF MS for biomarker assessment. Proteomics, 13(20), pp. 2967-2975. (doi: 10.1002/pmic.201300100)

MacDonald, A.J., Small, A.C., Greig, C.A., Husi, H., Ross, J.A., Stephens, N.A., Fearon, K.C.H. and Preston, T. (2013) A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis. Rapid Communications in Mass Spectrometry, 27(15), pp. 1769-1777. (doi: 10.1002/rcm.6622)

Husi, H., Skipworth, R.J., Fearon, K.C.H. and Ross, J.A. (2013) LSCluster, a large-scale sequence clustering and aligning software for use in partial identity mapping and splice-variant analysis. Journal of Proteomics, 84, pp. 185-189. (doi: 10.1016/j.jprot.2013.04.006)

Husi, H., Barr, J.B., Skipworth, R.J.E., Stephens, N., Greig, C.A., Wackerhage, H., Barron, R., Fearon, K.C.H. and Ross, J.A. (2013) The human urinary proteome fingerprint database UPdb. International Journal of Proteomics, 2013(760208), (doi: 10.1155/2013/760208)

Husi, H., Sanchez-Niño, M., Delles, C. , Mullen, W. , Vlahou, A., Ortiz, A. and Mischak, H. (2013) A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Systems Biology, 7(110), (doi: 10.1186/1752-0509-7-110)

Kilgour, A. H.M. et al. (2013) Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing. PLoS ONE, 8(12), e84057. (doi: 10.1371/journal.pone.0084057) (PMID:24391882) (PMCID:PMC3877148)

2012

Gallagher, I.J., Stephens, N.A., MacDonald, A.J., Skipworth, R.J.E., Husi, H., Greig, C.A., Ross, J.A., Timmons, J.A. and Fearon, K.C.H. (2012) Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies. Clinical Cancer Research, 18(10), pp. 2817-27. (doi: 10.1158/1078-0432.CCR-11-2133)

2011

Husi, H., Fearon, K. C. and Ross, J. A. (2011) Can a simple proteomics urine test assist in the early diagnosis of early-stage cancer? Expert Review of Proteomics, 8(5), pp. 555-557. (doi: 10.1586/epr.11.52)

Skipworth, R. J.E., Husi, H. and Ross, J. A. (2011) How close are we to finding noninvasive markers for upper GI tract cancer? Future Oncology, 7(10), pp. 1121-1124. (doi: 10.2217/fon.11.90)

Husi, H., Stephens, N., Cronshaw, A., MacDonald, A., Gallagher, I., Greig, C., Fearon, K. C.H. and Ross, J. A. (2011) Proteomic analysis of urinary upper gastrointestinal cancer markers. Proteomics Clinical Applications, 5(5-6), pp. 289-299. (doi: 10.1002/prca.201000107)

2010

Husi, H. et al. (2010) Selective chemical intervention in the proteome of Caenorhabditis elegans. Journal of Proteome Research, 9(11), pp. 6060-6070. (doi: 10.1021/pr100427c)

2006

Collins, M. O., Husi, H., Yu, L., Brandon, J. M., Anderson, C. N.G., Blackstock, W. P., Choudhary, J. S. and Grant, S. G.N. (2006) Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. Journal of Neurochemistry, 97(S1), pp. 16-23. (doi: 10.1111/j.1471-4159.2005.03507.x) (PMID:16635246)

2005

Collins, M. O., Yu, L., Husi, H., Blackstock, W. P., Choudhary, J. S. and Grant, S. G.N. (2005) Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry. Science's Stke, 2005(298), pl6. (doi: 10.1126/stke.2982005pl6) (PMID:16118397)

Collins, M. O., Yu, L., Coba, M. P., Husi, H., Campuzano, I., Blackstock, W. P., Choudhary, J. S. and Grant, S. G.N. (2005) Proteomic analysis of in vivo phosphorylated synaptic proteins. Journal of Biological Chemistry, 280(7), pp. 5972-5982. (doi: 10.1074/jbc.M411220200) (PMID:15572359)

2004

Hermjakob, H. et al. (2004) The HUPO PSI's Molecular Interaction format—a community standard for the representation of protein interaction data. Nature Biotechnology, 22(2), pp. 177-183. (doi: 10.1038/nbt926)

Husi, H. (2004) NMDA receptors, neural pathways, and protein interaction databases. International Review of Neurobiology, 61, pp. 49-77. (doi: 10.1016/S0074-7742(04)61003-8) (PMID:15482811)

2003

Nada, S., Shima, T., Yanai, H., Husi, H., Grant, S. G.N., Okada, M. and Akiyama, T. (2003) Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn. Journal of Biological Chemistry, 278(48), pp. 47610-47621. (doi: 10.1074/jbc.M303873200) (PMID:13129934)

Garry, E. M., Moss, A., Delaney, A., O'Neill, F., Blakemore, J., Bowen, J., Husi, H., Mitchell, R., Grant, S. G.N. and Fleetwood-Walker, S. M. (2003) Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Current Biology, 13(4), pp. 321-328. (doi: 10.1016/S0960-9822(03)00084-8) (PMID:12593798)

Husi, H. and Grant, S. G.N. (2003) Construction of a protein-protein interaction database (PPID) for synaptic biology. In: Kötter, R. (ed.) Neuroscience Databases: A Practical Guide. Springer: Boston, pp. 51-62. ISBN 9781461353843 (doi: 10.1007/978-1-4615-1079-6_4)

2001

Grant, S. G.N. and Husi, H. (2001) Proteomics of multiprotein complexes: answering fundamental questions in neuroscience. Trends in Biotechnology, 19(10 Sup), S49-S54. (doi: 10.1016/S0167-7799(01)01799-1) (PMID:11780971)

Husi, H. and Walkinshaw, M. D. (2001) Purification of factor X by hydrophobic interaction chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 755(1-2), pp. 367-371. (doi: 10.1016/S0378-4347(01)00112-8) (PMID:11393727)

Husi, H. and Grant, S. G.N. (2001) Proteomics of the nervous system. Trends in Neurosciences, 24(5), pp. 259-266. (doi: 10.1016/S0166-2236(00)01792-6) (PMID:11311377)

Husi, H. and Grant, S. G.N. (2001) Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain. Journal of Neurochemistry, 77(1), pp. 281-291. (doi: 10.1046/j.1471-4159.2001.00248.x) (PMID:11279284)

2000

Husi, H., Ward, M. A., Choudhary, J. S., Blackstock, W. P. and Grant, S. G.N. (2000) Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nature Neuroscience, 3(7), pp. 661-669. (doi: 10.1038/76615)

1999

Husi, H. and Walkinshaw, M. D. (1999) Separation of human vitamin K-dependent coagulation proteins using hydrophobic interaction chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 736(1-2), pp. 77-88. (doi: 10.1016/S0378-4347(99)00437-5) (PMID:10676986)

Dornan, J., Page, A. P., Taylor, P., Wu, S.-y., Winter, A. D., Husi, H. and Walkinshaw, M. D. (1999) Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans. Journal of Biological Chemistry, 274(49), pp. 34877-34883. (doi: 10.1074/jbc.274.49.34877) (PMID:10574961)

1998

Denton, H., Smith, M., Husi, H., Uhrin, D., Barlow, P. N., Batt, C. A. and Sawyer, L. (1998) Isotopically labeled bovine beta-lactoglobulin for NMR studies expressed in Pichia pastoris. Protein Expression and Purification, 14(1), pp. 97-103. (doi: 10.1006/prep.1998.0924) (PMID:9758756)

Taylor, P., Page, A. P., Kontopidis, G., Husi, H. and Walkinshaw, M. D. (1998) The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi. FEBS Letters, 425(2), pp. 361-366. (doi: 10.1016/S0014-5793(98)00264-6) (PMID:9559680)

1997

Husi, H., Schörgendorfer, K., Stempfer, G., Taylor, P. and Walkinshaw, M. D. (1997) Prediction of substrate-specific pockets in cyclosporin synthetase. FEBS Letters, 414(3), pp. 532-536. (doi: 10.1016/S0014-5793(97)01064-8) (PMID:9323029)

Taylor, P., Husi, H., Kontopidis, G. and Walkinshaw, M. D. (1997) Structures of cyclophilin-ligand complexes. Progress in Biophysics and Molecular Biology, 67(2-3), pp. 155-181. (doi: 10.1016/S0079-6107(97)00014-X) (PMID:9446934)

1994

Husi, H. and Zurini, M. G.M. (1994) Comparative binding studies of cyclophilins to cyclosporin A and derivatives by fluorescence measurements. Analytical Biochemistry, 222(1), pp. 251-255. (doi: 10.1006/abio.1994.1481) (PMID:7856857)

Husi, H., Luyten, M. A. and Zurini, M. G.M. (1994) Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin. Journal of Biological Chemistry, 269(19), pp. 14199-14204. (PMID:7514602)

1992

Ryffel, B., Woerly, G., Quesniaux, V. F.J., Husi, H. and Foxwell, B. M.J. (1992) Covalent binding of cyclosporine inhibits irreversibly T-lymphocyte activation. Biochemical Pharmacology, 43(5), pp. 953-960. (doi: 10.1016/0006-2952(92)90598-D) (PMID:1554393)

Foxwell, B. M.J., Woerly, G., Husi, H., Mackie, A., Quesniaux, V. F.J., Hiestand, P. C., Wenger, R. M. and Ryffel, B. (1992) Identification of several cyclosporine binding proteins in lymphoid and non-lymphoid cells in vivo. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1138(2), pp. 115-121. (doi: 10.1016/0925-4439(92)90050-W) (PMID:1540657)

This list was generated on Wed Mar 22 13:28:24 2023 GMT.

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