Scientific image - Guto


Endothelial dysfunction and vascular remodelling

The theme is interested in the causes and consequences of endothelial dysfunction and vascular remodelling within the context of cardiovascular disease.  In particular, the group is keen to better understand the endothelial and vascular smooth muscle adaptive and maladaptive response to injury. The group has expertise in hypertension, atherosclerosis, immune modulation and the role of adipose derived cytokines.

Small vessel disease of the brain

Our research investigates the consequences and contributions of cerebrovascular disease to normal vascular function and conditions such as stroke or vascular cognitive impairment.  We span preclinical, clinical and translational studies.


In our sub-theme, we study mechanisms that regulate vascular reactivity and contribute to the development of hypertension. We take a multidisciplinary approach that spans the most basic molecular studies to studies in man. Our aim is to identify mechanisms of disease and novel therapeutic interventions.


Our research investigates vascular structure, function and remodelling processes in the mother, placenta and fetus during normal pregnancy and in pregnancies complicated by hypertension, gestational diabetes and preeclampsia. Our translational studies range from laboratory-based to pre-clinical and clinical investigations.