Research

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Dritsoula, A., Dowsett, L., Pilotti, C., O'Connor, M. N., Moss, S. E., Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway Scientific Reports, 12, (doi: 10.1038/s41598-022-08516-2)

O'Connor, M. N., Kallenberg, D. M., Camilli, C., Pilotti, C., Dritsoula, A., Jackstadt, R., Bowers, C. E., Watson, H. A., Alatsatianos, M., Ohme, J., Dowsett, L., George, J., Blackburn, J. W.D., Wang, X., Singhal, M., Augustin, H. G., Ager, A., Sansom, O. J., Moss, S. E., Greenwood, J. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency Med, 2, pp. 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002)

Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis Journal of Clinical Medicine, 9, (doi: 10.3390/jcm9093026)

Dowsett, L., Piper, S., Slaviero, A., Dufton, N., Wang, Z., Boruc, O., Delahaye, M., Colman, L., Kalk, E., Tomlinson, J., Birdsey, G., Randi, A. M., Leiper, J. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis Circulation, 131, pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064)

Lambden, S., Kelly, P., Ahmetaj-Shala, B., Wang, Z., Lee, B., Nandi, M., Torondel, B., Delahaye, M., Dowsett, L., Piper, S., Tomlinson, J., Caplin, B., Colman, L., Boruc, O., Slaviero, A., Zhao, L., Oliver, E., Khadayate, S., Singer, M., Arrigoni, F., Leiper, J. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis Arteriosclerosis, Thrombosis, and Vascular Biology, 35, pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278)

Tsang, H., Leiper, J., Lao, K. H., Dowsett, L., Delahaye, M. W., Barnes, G., Wharton, J., Howard, L., Iannone, L., Lang, N. N., Wilkins, M. R., Wojciak-Stothard, B. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function Pulmonary Circulation, 3, pp. 675-691. (doi: 10.1086/674440)

Caplin, B., Wang, Z., Slaviero, A., Tomlinson, J., Dowsett, L., Delahaye, M., Salama, A., Wheeler, D. C., Leiper, J. (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure Arteriosclerosis, Thrombosis, and Vascular Biology, 32, pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078)