Welcome to SCMH - Dr William Fuller and Team

Image of Will FullerThe Fuller lab is very much looking forward to becoming part of the SCMH team. We are really excited about the opportunities for new collaborative projects, and to hear about the research programmes happening in Glasgow. We will be busy moving the lab from Dundee to Glasgow throughout December, and hope to be fully operational in early January.

The research theme in my laboratory is the organisation and regulation of cardiac membrane proteins and microdomains in health and disease. We employ a variety of subcellular fractionation, imaging, affinity purification, biochemical and cell and organ physiological techniques to investigate molecular, macromolecular, whole cell and whole organ behaviours. Using these approaches we make fundamental observations into the molecular physiology of membrane transporters and their regulators in order to better understand both physiological control of cardiac function, and how these relationships can be targeted to ameliorate dysfunction. Our long-term objective is the translation of basic molecular bioscience into therapeutic strategies for cardiovascular diseases. Current principal research projects are:

• Regulation of the Na pump by phosphorylation and palmitoylation of its regulatory and catalytic subunits.
• The Na pump as a therapeutic target in cardiac hypertrophy and failure.
• Clinical phenotype of a common genetic variant of the Na pump regulator phospholemman.
• Characterising dynamic changes in cardiomyocyte caveolae during adrenergic signalling.
• Regulation of ventricular sodium calcium exchanger and L-type Ca channels by palmitoylation.
• Regulation of HCN4 in the sino atrial node by palmitoylation.
• Protection of the ventricular myocardium from ischemic injury by activators of the Nrf2 pathway.
• The cardiac palmitoyl transferase DHHC5 in health and disease.

Dr William Fuller's Group;

Dr Jacqueline Howie ‌

Image of Jacqueline HowieI obtained my BSc in Anatomical sciences from University Dundee where I remained as a Research Assistant investigating the sigma receptor as a therapeutic target in cancer in the Department of Surgery and molecular oncology under the supervision of Dr Barbara Spruce. I then studied for a PhD investigating the role of the anterior gradient proteins in hormone related cancers under the supervision of Dr Pete Ross. Following my PhD I moved to working in the cardiac field establishing a new technique which I learned during a sabbatical in Columbia University, NYC to analyse endothelial function in patients under the supervision of Professor Chim Lang. I have since continued my interest in the heart working on cardiac accessory protein of the sodium pump, phospholemman:specifically on protein it interacts with and the post-translational modifications which influence it.


 Dr Calgar Goek

Image of Caglar Goek‌I joined in Dr Fuller's Group as Postdoctoral Research Assistant quite recently. I obtained my Bachelor's Degree in Biology with the double major degree in Chemistry in Cukurova University and then conducted my master project in Biomedical Engineering (BME) Institute at Bogazici University in Turkey. Afterwards, I moved to Max Delbruck Centrum (MDC) for Molecular Medicine in Berlin for my PhD. During my PhD, I focused on the molecular physiology of mechanically activated (MA) ion channels and pharmacological strategies to cope with neuropathic pain. In Dr Fuller's Group, I aims to bring new insights into the role of the electrogenic Na/Ca exchanger (NCX1) palmitoylation in cardiac function ."

Dr Olivia Robertson-Gray

Image of Olivia Robertson‌BSc (Hons) Immunology and Pharmacology, University of Strathclyde
MRes Exercise Science, University of Glasgow
PgCert Research Methods, Robert Gordon University
AFHEA, Associate Fellow of the Higher Education Academy
PhD Cardiovascular Pharmacology, Robert Gordon University

Research interests include GPCRs, myocardial ischaemia/reperfusion injury, atherosclerosis and vascular function.

Techniques include: haemodynamic measurements in rodents (Pressure-Volume Loop analysis), isolated heart studies (Langendorff model; mouse and rat), myography, genotyping, microdissection, primary cell isolation, PCR, cell culture, calcium uptake and release studies (isolated cardiomyocytes), exercise training in rodents, high throughput screening of compounds (Corning Epic Technology) and histology.



First published: 20 December 2017